Lee Quinton | Profiles RNS

Lee J. Quinton, PhD

Associate Professor

Boston University School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

PhD, Louisiana State University

Websites

	Pulmonary, Allergy, Sleep & Critical Care Medicine Faculty
	Immunology Training Program Faculty
	LinkedIn

ORCID : 0000-0003-1938-2507

My expertise lies in the areas of the biology of acute pulmonary inflammation and the innate immune response to microorganisms in the lung.

Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine

Center Faculty Member
Boston University School of Medicine
Pulmonary Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

BU Sponsored Research
NIH RePORTER Sponsored Research

Inducible epithelial resilience during pneumonia
07/01/2017 - 06/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL111449-06

Liver-derived protection during pneumonia and sepsis
04/01/2017 - 01/31/2021 (PI)
NIH/National Institute of General Medical Sciences
1R01GM120060-01A1

The Biology of LIF During Pneumonia
06/01/2016 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL111449-05

The Biology of LIF During Pneumonia
08/15/2012 - 05/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL111449-04

Lung-Liver Axis During Pneumonia
09/01/2010 - 06/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5R00HL092956-05

Yr	Title	Project-Sub Proj	Pubs
2018	Liver-derived protection during pneumonia and sepsis	5R01GM120060-02
2017	Liver-derived protection during pneumonia and sepsis	1R01GM120060-01A1
2016	The Biology of LIF During Pneumonia	4R01HL111449-05	9
2014	The Biology of LIF During Pneumonia	5R01HL111449-03	9
2013	The Biology of LIF During Pneumonia	5R01HL111449-02	9
2012	The Biology of LIF During Pneumonia	1R01HL111449-01A1	9
2012	Lung-Liver Axis During Pneumonia	5R00HL092956-05	12
2011	Lung-Liver Axis During Pneumonia	5R00HL092956-04	12
2010	Lung-Liver Axis During Pneumonia	4R00HL092956-03	12
2009	Lung-Liver Axis During Pneumonia	5K99HL092956-02	2

Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 05; 21(4):472-488.e10.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn
Traber, Katrina
Quinton, Lee

PMID: 28965766.

Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O''Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles.

Fine, Alan
Szymaniak, Aleksander
Chen, Felicia
Wasserman, Gregory
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Varelas, Xaralabos
Ai, Xingbin

PMID: 28920925.

Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Coleman, Fadie
Kramnik, Igor
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Jones, Matthew
Pelton, Stephen

PMID: 28368460; DOI: 10.1093/infdis/jix159;.

Kozlowski E, Wasserman GA, Morgan M, O''Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. PLoS One. 2017; 12(6):e0179797.View Related Profiles.

Gower, Adam
Kozlowski, Elyse
Wasserman, Gregory
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
Ieong, Michael
Gummuluru, Suryaram

PMID: 28665939.

Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L548-L558.View Related Profiles.

Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Kim, Yuri

PMID: 28522567.

Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP. Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia. Mucosal Immunol. 2018 Jan; 11(1):220-235.View Related Profiles.

Coleman, Fadie
Wasserman, Gregory
Dooms, Hans
Mizgerd, Joseph
Yamamoto, Kazuko
Hilliard, Kristie
Quinton, Lee

PMID: 28513594.

Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18.View Related Profiles.

Gower, Adam
Belkina, Anna
Wasserman, Gregory
Mizgerd, Joseph
Quinton, Lee
Ramirez, Maria
Jones, Matthew

PMID: 27064756; PMCID: PMC5023025; DOI: 10.1165/rcmb.2015-0261OC;.

Traber KE, Hilliard KL, Allen E, Wasserman GA, Yamamoto K, Jones MR, Mizgerd JP, Quinton LJ. Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):479-88.View Related Profiles.

Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew

PMID: 25692402; PMCID: PMC4742898; DOI: 10.1165/rcmb.2014-0342OC;.

Hilliard KL, Allen E, Traber KE, Yamamoto K, Stauffer NM, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):378-90.View Related Profiles.

Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Stauffer, Nicole

PMID: 25607543; PMCID: PMC4566062; DOI: 10.1165/rcmb.2014-0195OC;.

Hilliard KL, Allen E, Traber KE, Kim Y, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. Activation of Hepatic STAT3 Maintains Pulmonary Defense during Endotoxemia. Infect Immun. 2015 Oct; 83(10):4015-27.View Related Profiles.

Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Kim, Yuri

PMID: 26216424; PMCID: PMC4567648; DOI: 10.1128/IAI.00464-15;.

Showing 10 of 45 results. Show More

Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR. Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. PLoS One. 2014; 9(10):e109072.View Related Profiles.

Coleman, Fadie
Wasserman, Gregory
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Ieong, Michael

PMID: 25299049; PMCID: PMC4192124; DOI: 10.1371/journal.pone.0109072;.

Quinton LJ, Mizgerd JP. Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling. Annu Rev Physiol. 2015; 77:407-30.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee

PMID: 25148693; PMCID: PMC4366440; DOI: 10.1146/annurev-physiol-021014-071937;.

Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands. Front Pharmacol. 2014; 5:8. PMID: 24567720.

Yamamoto K, Ahyi AN, Pepper-Cunningham ZA, Ferrari JD, Wilson AA, Jones MR, Quinton LJ, Mizgerd JP. Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):253-62.View Related Profiles.

Wilson, Andrew
Ahyi, Ayele-Nati
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Jones, Matthew

PMID: 24010952; PMCID: PMC3930948; DOI: 10.1165/rcmb.2013-0114OC;.

Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP. Roles of STAT3 in protein secretion pathways during the acute-phase response. Infect Immun. 2013 May; 81(5):1644-53.View Related Profiles.

Ahyi, Ayele-Nati
Remick, Daniel
Mizgerd, Joseph
Mella, Juan
Quinton, Lee
Jones, Matthew

PMID: 23460517; PMCID: PMC3647986; DOI: 10.1128/IAI.01332-12;.

Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP. Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet. 2012; 8(11):e1003105.View Related Profiles.

Kozlowski, Elyse
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 23209448; PMCID: PMC3510031; DOI: 10.1371/journal.pgen.1003105;.

Quinton LJ. Evaluating the NET influence of inflammation on pneumonia biology. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):943-4. PMID: 23155213; PMCID: PMC3530208; DOI: 10.1164/rccm.201209-1702ED;.

Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol. 2012 Sep 1; 189(5):2450-9.View Related Profiles.

Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Ramirez, Maria
Jones, Matthew
Cao, Yu-Xia

PMID: 22844121; PMCID: PMC3424336; DOI: 10.4049/jimmunol.1200634;.

Quinton LJ, Mizgerd JP, Hilliard KL, Jones MR, Kwon CY, Allen E. Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol. 2012 Jun 15; 188(12):6300-8.View Related Profiles.

Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew

PMID: 22581855; PMCID: PMC3370070; DOI: 10.4049/jimmunol.1200256;.

Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012 May 1; 122(5):1758-63.View Related Profiles.

Spira, Avrum
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Pelton, Stephen
Sabharwal, Vishakha

PMID: 22466650; PMCID: PMC3336975; DOI: 10.1172/JCI59408;.

Quinton LJ. GM-CSF: a double dose of protection during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 1; 302(5):L445-6. PMID: 22268117; DOI: 10.1152/ajplung.00022.2012;.

Blahna MT, Jones MR, Quinton LJ, Matsuura KY, Mizgerd JP. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity. J Biol Chem. 2011 Dec 9; 286(49):42381-9.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 22006926; PMCID: PMC3234974; DOI: 10.1074/jbc.M111.259689;.

Zamjahn JB, Quinton LJ, Mack JC, Frevert CW, Nelson S, Bagby GJ. Differential flux of macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant from the lung after intrapulmonary delivery. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L568-74. PMID: 21743027; PMCID: PMC3191755; DOI: 10.1152/ajplung.00340.2010;.

Pittet LA, Quinton LJ, Yamamoto K, Robson BE, Ferrari JD, Algül H, Schmid RM, Mizgerd JP. Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):573-81.View Related Profiles.

Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee

PMID: 21216972; PMCID: PMC3175578; DOI: 10.1165/rcmb.2010-0210OC;.

Quinton LJ, Mizgerd JP. NF-?B and STAT3 signaling hubs for lung innate immunity. Cell Tissue Res. 2011 Jan; 343(1):153-65.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee

PMID: 20872151; DOI: 10.1007/s00441-010-1044-y;.

Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009 Sep; 11(9):1157-63.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 19701194; PMCID: PMC2759306; DOI: 10.1038/ncb1931;.

Quinton LJ, Jones MR, Robson BE, Mizgerd JP. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect Immun. 2009 Jun; 77(6):2417-26.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 19289507; PMCID: PMC2687329; DOI: 10.1128/IAI.01300-08;.

Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S. The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide. Shock. 2009 Feb; 31(2):212-7.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee

PMID: 18520704; DOI: 10.1097/SHK.0b013e31817c0d7d;.

Quinton LJ, Jones MR, Robson BE, Simms BT, Whitsett JA, Mizgerd JP. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):699-706.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 18192501; PMCID: PMC2396249; DOI: 10.1165/rcmb.2007-0365OC;.

Happel KI, Rudner X, Quinton LJ, Movassaghi JL, Clark C, Odden AR, Zhang P, Bagby GJ, Nelson S, Shellito JE. Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. Alcohol. 2007 Aug; 41(5):325-33. PMID: 17889309; PMCID: PMC2044567.

Johnston RA, Mizgerd JP, Flynt L, Quinton LJ, Williams ES, Shore SA. Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):477-84.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee

PMID: 17575079; PMCID: PMC2176124.

Quinton LJ, Jones MR, Simms BT, Kogan MS, Robson BE, Skerrett SJ, Mizgerd JP. Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol. 2007 Feb 1; 178(3):1896-903.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 17237440; PMCID: PMC2674289.

Poonia B, Nelson S, Bagby GJ, Zhang P, Quniton L, Veazey RS. Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Res Hum Retroviruses. 2006 Jun; 22(6):589-94. PMID: 16796534.

Krishnamurthy VM, Quinton LJ, Estroff LA, Metallo SJ, Isaacs JM, Mizgerd JP, Whitesides GM. Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide. Biomaterials. 2006 Jul; 27(19):3663-74.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee

PMID: 16527349.

Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS, Mizgerd JP. Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis. 2006 Feb 1; 193(3):360-9.View Related Profiles.

Mizgerd, Joseph
Quinton, Lee
Jones, Matthew

PMID: 16388483; PMCID: PMC2674298.

Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med. 2005 Sep 19; 202(6):761-9. PMID: 16157683; PMCID: PMC2212952.

Quinton LJ, Nelson S, Zhang P, Happel KI, Gamble L, Bagby GJ. Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment. Alcohol Clin Exp Res. 2005 Jul; 29(7):1198-205. PMID: 16046875.

Badewa AP, Quinton LJ, Shellito JE, Mason CM. Chemokine receptor 5 and its ligands in the immune response to murine tuberculosis. Tuberculosis (Edinb). 2005 May; 85(3):185-95. PMID: 15850756.

Zhang P, Quinton LJ, Gamble L, Bagby GJ, Summer WR, Nelson S. The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemia. Shock. 2005 Apr; 23(4):344-52. PMID: 15803058.

Shahbazian LM, Quinton LJ, Bagby GJ, Nelson S, Wang G, Zhang P. Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation. Crit Care Med. 2004 Aug; 32(8):1740-6. PMID: 15286552.

Quinton LJ, Nelson S, Zhang P, Boé DM, Happel KI, Pan W, Bagby GJ. Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L465-72. PMID: 14617513.

Boé DM, Nelson S, Zhang P, Quinton L, Bagby GJ. Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae. Alcohol Clin Exp Res. 2003 Nov; 27(11):1838-45. PMID: 14634502.

Happel KI, Zheng M, Young E, Quinton LJ, Lockhart E, Ramsay AJ, Shellito JE, Schurr JR, Bagby GJ, Nelson S, Kolls JK. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol. 2003 May 1; 170(9):4432-6. PMID: 12707317; PMCID: PMC2841978.

Zhang P, Quinton LJ, Bagby GJ, Summer WR, Nelson S. Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge. J Infect Dis. 2003 Jan 1; 187(1):62-9. PMID: 12508147.

Quinton LJ, Nelson S, Boé DM, Zhang P, Zhong Q, Kolls JK, Bagby GJ. The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challenges. J Infect Dis. 2002 May 15; 185(10):1476-82. PMID: 11992284.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 45 publications over 16 distinct years, with a maximum of 6 publications in 2012 and 2017