Lawreen Heller Connors, PhD
Charles J. Brown Research Professor in Amyloidosis
Boston University School of Medicine
Pathology & Laboratory Medicine

PhD, Boston University
MS, Tufts University




Dr. Connors received dual undergraduate degrees in Chemistry and Mathematics from Boston College, a master’s degree in Chemistry from Tufts University, and doctoral degree in Biochemistry from Boston University. She joined the Amyloidosis Center as a post-doctoral trainee in 1994, and obtained faculty appointments in the Departments of Biochemistry and Pathology & Laboratory Medicine in 1998 and 2009, respectively.
Dr. Connors focuses her basic science research on uncovering the protein and genetic determinants that underlie the formation of amyloid. The early stages of her career featured structural analyses of amyloid-causing transthyretin (TTR) mutants, mainly those causing cardiac dysfunction. More recently, her studies have been focused on wild-type TTR amyloidosis, an age-related disease now recognized as an under-appreciated cause of heart failure in the elderly. She has received continuous support from the NIH and foundation grants, as well as industry-sponsored research agreements, and has authored more than 100 peer-reviewed scholarly articles and book chapters.
In 2009, Dr. Connors played a major role in establishment of the Amyloid Pathology Diagnostic Testing Laboratory in the Amyloidosis Center, a CAP-accredited and CLIA-certified facility that offers histologic and molecular testing for amyloid. Dr. Connors teaches GMS classes on systemic amyloidosis, and has mentored more than 20 master’s, doctoral and postdoctoral students. She has served on multiple local, national and international committees, and is Director of the Amyloidosis Center Gerry Laboratory and Co-Director of the Amyloid Pathology Diagnostic Testing Laboratory.

Associate Professor
Boston University School of Medicine
Biochemistry


Member
Boston University
Amyloidosis Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations)
05/01/2019 - 02/29/2024 (Subcontract PI)
Boston Medical Center Corporation NIH NHLBI
1R01HL139671-01A1

Renal Immunoglobulin Light Chain Amyloidosis: Translational studies probing disease mechanism as a platform for drug development.
09/01/2018 - 08/31/2022 (PI)
Florida Wildflower Foundation


Molecular mechanism of senile cardiac amyloidosis
09/15/2017 - 08/31/2019 (PI)
NIH/National Institute on Aging
2R56AG031804-06A1

Validation of blood biomarkers for recognition and monitoring of age-related, wild-type Transthyretin Amyloidosis (ATTRwt)
01/01/2018 - 12/31/2018 (PI)
E. Rhodes & Leona B. Carpenter Foundation


Contribution of Immunoglobulin Constant Domain to Amyloid Formation, Part 4
01/01/2011 - 12/31/2018 (PI)
Florida Wildflower Foundation


Immunohistochemical analyses of Proclara Fusion Protein, NPT189, in Amyloid-infiltrated human heart tissues
01/02/2018 - 06/30/2018 (PI)
Proclara Biosciences


Congo Red Histologic Analysis for Mouse Tissue - DICERNA Pharmaceuticals, Inc.
02/22/2017 - 03/31/2017 (PI)
Dicerna Pharmaceuticals, Inc.


Serum biomarker identification of cardiac amyloidosis in elderly African Americans
04/01/2016 - 03/31/2017 (Subcontract PI)
Boston Medical Center Corporation NIH NIA
5R21AG050206-02

Discovery: A study examining the prevalence of TTR mutations in subjects
09/01/2015 - 08/31/2016 (PI)
Alnylam Pharmaceuticals, Inc.


Blood Profiling for Biomarkers in Age-related Senile Systemic Amyloidosis (SSA)
07/01/2014 - 06/30/2016 (PI)
E. Rhodes & Leona B. Carpenter Foundation


Showing 10 of 17 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2017 Molecular mechanism of senile cardiac amyloidosis 2R56AG031804-06A1 6
2013 Molecular mechanism of senile cardiac amyloidosis 5R01AG031804-05 21
2012 Molecular mechanism of senile cardiac amyloidosis 5R01AG031804-04 21
2011 S-SULFONATION OF SERUM TRANSTHYRETIN IN SSA/PTMS OF TTR IN AMYLOID FIBRILS 5P41RR010888-15-5084 259
2011 Molecular mechanism of senile cardiac amyloidosis 5R01AG031804-03 21
2010 S-SULFONATION OF SERUM TRANSTHYRETIN IN SSA/PTMS OF TTR IN AMYLOID FIBRILS 5P41RR010888-14-6781 259
2010 Molecular mechanism of senile cardiac amyloidosis 5R01AG031804-02 21
2009 Molecular mechanism of senile cardiac amyloidosis 1R01AG031804-01A2 21
2009 S-SULFONATION OF SERUM TRANSTHYRETIN IN SSA/PTMS OF TTR IN AMYLOID FIBRILS 5P41RR010888-13-6127 259
2009 ULTRACENTRIFUGATION OF AMYLOID PROTEIN COMPLEXES WITH FLUORESCENCE DETECTION 5P41RR010888-13-6199 259
Showing 10 of 17 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Schulman A, Connors LH, Weinberg J, Mendelson LM, Joshi T, Shelton AC, Sanchorawala V. Patient outcomes in light chain (AL) amyloidosis: The clock is ticking from symptoms to diagnosis. Eur J Haematol. 2020 Jun 21.View Related Profiles. PMID: 32564450; DOI: 10.1111/ejh.13472;
     
  2. Dasari AKR, Hung I, Michael B, Gan Z, Kelly JW, Connors LH, Griffin RG, Lim KH. Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway In Vivo. Biochemistry. 2020 May 19; 59(19):1800-1803. PMID: 32338497
     
  3. Lohrmann G, Pipilas A, Mussinelli R, Gopal DM, Berk JL, Connors LH, Vellanki N, Hellawell J, Siddiqi OK, Fox J, Maurer MS, Ruberg FL. Stabilization of Cardiac Function With Diflunisal in Transthyretin (ATTR) Cardiac Amyloidosis. J Card Fail. 2019 Dec 02.View Related Profiles. PMID: 31805416
     
  4. Staron A, Connors LH, Ruberg FL, Mendelson LM, Sanchorawala V. A new era of amyloidosis: the trends at a major US referral centre. Amyloid. 2019 Dec; 26(4):192-196.View Related Profiles. PMID: 31306033
     
  5. Tahir UA, Doros G, Kim JS, Connors LH, Seldin DC, Sam F. Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure. Sci Rep. 2019 06 12; 9(1):8552.View Related Profiles. PMID: 31189919
     
  6. Yunis A, Doros G, Luptak I, Connors LH, Sam F. Use of Ventilatory Efficiency Slope as a Marker for Increased Mortality in Wild-Type Transthyretin Cardiac Amyloidosis. Am J Cardiol. 2019 07 01; 124(1):122-130.View Related Profiles. PMID: 31053293
     
  7. Boldbaatar B, Maenpaa E, Sikora Hanson J, Connors L. Analysis of the non-coding rs3764479 mutation in the proximal promoter of the transthyretin gene. Amyloid. 2019; 26(sup1):83-84.View Related Profiles. PMID: 31343312
     
  8. Torres-Arancivia C, Chang D, Zaia J, Connors LH. Structural studies of serum clusterin in ATTRwt amyloidosis. Amyloid. 2019; 26(sup1):51-52.View Related Profiles. PMID: 31343316
     
  9. Torres-Arancivia C, Connors LH. Effect of diflunisal on clusterin levels in ATTRwt amyloidosis. Amyloid. 2019; 26(sup1):49-50. PMID: 31343317
     
  10. Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics. Amyloid. 2018 Sep; 25(3):148-155.View Related Profiles. PMID: 30032658
     
Showing 10 of 95 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 92 publications over 29 distinct years, with a maximum of 8 publications in 2017

YearPublications
19831
19841
19854
19861
19871
19941
19981
19994
20003
20012
20023
20032
20042
20054
20061
20076
20084
20093
20104
20116
20122
20135
20144
20153
20162
20178
20185
20197
20202
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

amyloidosis
cardiomyopathy
diflunisal
transthyretin
Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
Google Map


Connors's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Media Mentions
_
Co-Authors
_
Similar People
_
Same Department