Xingbin Ai | Profiles RNS

Xingbin Ai, PhD

Adjunct Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

PhD, Case Western Reserve University
BS, Fudan University

Expertise and interests include:

REGULATION OF STEM CELL FUNCTION AND AGING BY HEPARAN SULFATE AND SULFS:
Environmental signals play crucial roles in self-renewal of stem cells, tissue regeneration and aging. Ai lab investigates heparan sulfate-dependent mechanisms that regulate extracellular signaling during stem cell maintenance and regeneration of the skeletal muscle. Our study is focused on two heparan sulfate-modifying enzymes called Sulfs.

NEUROGENESIS AND NEUROPLASTICITY IN PULMONARY DISEASES:
The respiratory tract is known to be innervated by two groups of neurons. The intrinsic neurons have cell bodies located within the tissue, while the extrinsic neurons have their cell bodies located in the central and peripheral nervous system and their axons innervating airway smooth muscle and neuroendocrine cells. Ai lab investigates neurotrophic signals that regulate neurogenesis in developing lung and neuroplasticity in pulmonary diseases. Our goal is to understand physiological roles of neural innervation in respiratory function, diseases and regeneration.

AIRWAY SMOOTH MUSCLE DEVELOPMENT AND REMODELING IN ASTHMA:
Airway smooth muscle hyperplasia and hyper-reactivity are key features of asthma. Ai lab, in collaboration with Dr. Alan Fine’s lab, investigates mechanisms underlying the formation and remodeling of airway smooth muscle. We are particularly interested in the sonic hedgehog pathway in control of airway smooth muscle development.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

The Fetal Lung Mesothelial Differentiation Program
08/05/2013 - 05/31/2017 (Co-Investigator of Sub-Project / SP)
PI: Alan Fine, MD
NIH/National Heart, Lung, and Blood Institute
5R01HL116163-03

Identifying the Molecular Phenotype of Normal and Asthmatic Bronchial Smooth Muscle
01/01/2012 - 12/31/2015 (Multi-PI)
PI: Xingbin Ai, PhD
NIH/National Heart, Lung, and Blood Institute
5R21HL112619-02

Linking Increased Innervation to Persistent BSM Hyper-reactivity
07/01/2012 - 06/30/2015 (PI)
American Asthma Foundation

Identification of Sulfs as Therapeutic Targets for the Treatment of Age-Impaired Skeletal Muscle Regeneration
03/15/2010 - 07/31/2014 (PI)
NIH/National Institute on Aging
5R01AG034939-05

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Does age matter for the development of pathogenic T helper 2 resident memory cells in the lung?	1R21AI180866-01
2023	COVID-19 imprints airway basal cells to impair epithelium regeneration	1R21AI173494-01A1
2023	Age-related mechanisms of T helper 2 memory in the early lung	5R01HL154549-03
2022	Age-related mechanisms of T helper 2 memory in the early lung	5R01HL154549-02
2021	Age-related mechanisms of T helper 2 memory in the early lung	1R01HL154549-01A1
2020	Development of PNEC innervation and neuroplasticity after early life insult	7R01HL132991-04	7
2019	Development of PNEC innervation and neuroplasticity after early life insult	5R01HL132991-03	7
2018	Development of PNEC innervation and neuroplasticity after early life insult	5R01HL132991-02	7
2017	Development of PNEC innervation and neuroplasticity after early life insult	1R01HL132991-01A1	7
2016	The Fetal Lung Mesothelial Differentiation Program	4R01HL116163-04	13

Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Bankoti K, Wang W, Amonkar GM, Xiong L, Shui JE, Zhao C, Van E, Mwase C, Park JA, Mou H, Fang Y, Que J, Bai Y, Lerou PH, Ai X. Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation. Am J Respir Cell Mol Biol. 2024 Jan; 70(1):26-38. PMID: 37699145; PMCID: PMC10768838; DOI: 10.1165/rcmb.2023-0104OC;

Dylong F, Riedel J, Amonkar GM, Peukert N, Lieckfeldt P, Sturm K, Höxter B, Tse WH, Miyake Y, Moormann M, Bode LM, Mayer S, Keijzer R, Lacher M, Ai X, Gosemann JH, Wagner R. Overactivated Epithelial NF-?B Disrupts Lung Development in Congenital Diaphragmatic Hernia. Am J Respir Cell Mol Biol. 2023 Nov; 69(5):545-555. PMID: 37552822

Zhao C, Wang W, Bai Y, Amonkar G, Mou H, Olejnik J, Hume AJ, Mühlberger E, Fang Y, Que J, Fearns R, Ai X, Lerou PH. Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells. bioRxiv. 2023 Sep 21.View Related Profiles.

Hume, Adam
Muhlberger, Elke
Olejnik, Judith
Fearns, Rachel
Ai, Xingbin

PMID: 37781574; PMCID: PMC10541147; DOI: 10.1101/2023.09.20.558606;

Bai Y, Li G, Yung L, Yu PB, Ai X. Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries. Am J Physiol Lung Cell Mol Physiol. 2023 Aug 01; 325(2):L114-L124. PMID: 37278410; PMCID: PMC10393320; DOI: 10.1152/ajplung.00293.2022;

Zhang Y, Black KE, Phung TN, Thundivalappil SR, Lin T, Wang W, Xu J, Zhang C, Hariri LP, Lapey A, Li H, Lerou PH, Ai X, Que J, Park JA, Hurley BP, Mou H. Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity. Am J Respir Cell Mol Biol. 2023 Jun; 68(6):664-678. PMID: 36753317; PMCID: PMC10257070; DOI: 10.1165/rcmb.2022-0299OC;

Wang W, Garcia C, Shao F, Cohen JA, Bai Y, Fine A, Ai X. Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life. J Allergy Clin Immunol. 2023 Aug; 152(2):386-399.View Related Profiles.

Fine, Alan
Ai, Xingbin

PMID: 36841266; PMCID: PMC10440294; DOI: 10.1016/j.jaci.2023.02.011;

Krishnamoorthy N, Walker KH, Brüggemann TR, Tavares LP, Smith EW, Nijmeh J, Bai Y, Ai X, Cagnina RE, Duvall MG, Lehoczky JA, Levy BD. The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2):e2206480120. PMID: 36595677; PMCID: PMC9926266; DOI: 10.1073/pnas.2206480120;

Bai Y, Ai X. Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle. J Vis Exp. 2022 May 05; (183). PMID: 35604150

Bai Y, Guedes AGP, Krishnan R, Ai X. CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility. J Allergy Clin Immunol. 2022 May; 149(5):1643-1654.e8. PMID: 34800431; PMCID: PMC9081122; DOI: 10.1016/j.jaci.2021.10.033;

Wang W, Ai X. Primary culture of immature, naïve mouse CD4+ T cells. STAR Protoc. 2021 Sep 17; 2(3):100756. PMID: 34430922; PMCID: PMC8369069; DOI: 10.1016/j.xpro.2021.100756;

Showing 10 of 52 results. Show More

Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347.View Related Profiles.

Tilston-Lunel, Andrew
Lenburg, Marc
Monti, Stefano
Varelas, Xaralabos
Ai, Xingbin

PMID: 34260916; PMCID: PMC8346236; DOI: 10.1016/j.celrep.2021.109347;

Shui JE, Wang W, Liu H, Stepanova A, Liao G, Qian J, Ai X, Ten V, Lu J, Cardoso WV. Prematurity alters the progenitor cell program of the upper respiratory tract of neonates. Sci Rep. 2021 05 24; 11(1):10799.View Related Profiles.

Cardoso, Wellington
Ai, Xingbin

PMID: 34031475; PMCID: PMC8144386; DOI: 10.1038/s41598-021-90093-x;

Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 04 20; 35(3):109011.View Related Profiles.

Fine, Alan
Cardoso, Wellington
Ai, Xingbin

PMID: 33882306; PMCID: PMC8140387; DOI: 10.1016/j.celrep.2021.109011;

Lu RA, Zeki AA, Ram-Mohan S, Nguyen N, Bai Y, Chmiel K, Pecic S, Ai X, Krishnan R, Ghosh CC. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins. Front Pharmacol. 2020; 11:469. PMID: 32435188; PMCID: PMC7218099; DOI: 10.3389/fphar.2020.00469;

Li G, Cohen JA, Martines C, Ram-Mohan S, Brain JD, Krishnan R, Ai X, Bai Y. Preserving Airway Smooth Muscle Contraction in Precision-Cut Lung Slices. Sci Rep. 2020 04 15; 10(1):6480. PMID: 32296115; PMCID: PMC7160136; DOI: 10.1038/s41598-020-63225-y;

Ram-Mohan S, Bai Y, Schaible N, Ehrlicher AJ, Cook DP, Suki B, Stoltz DA, Solway J, Ai X, Krishnan R. Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L323-L330.View Related Profiles.

Suki, Bela
Ai, Xingbin

PMID: 31774304; PMCID: PMC7052683; DOI: 10.1152/ajplung.00297.2019;

Wang W, Cohen JA, Wallrapp A, Trieu KG, Barrios J, Shao F, Krishnamoorthy N, Kuchroo VK, Jones MR, Fine A, Bai Y, Ai X. Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Immunity. 2019 12 17; 51(6):1102-1118.e7.View Related Profiles.

Fine, Alan
Jones, Matthew
Ai, Xingbin

PMID: 31757673; PMCID: PMC6937208; DOI: 10.1016/j.immuni.2019.10.002;

Levy BD, Abdulnour RE, Tavares A, Brüggemann TR, Norris PC, Bai Y, Ai X, Serhan CN. Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes. J Allergy Clin Immunol. 2020 01; 145(1):335-344. PMID: 31622689; PMCID: PMC7308163; DOI: 10.1016/j.jaci.2019.09.028;

Barrios J, Kho AT, Aven L, Mitchel JA, Park JA, Randell SH, Miller LA, Tantisira KG, Ai X. Pulmonary Neuroendocrine Cells Secrete ?-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models. Am J Respir Cell Mol Biol. 2019 06; 60(6):687-694.View Related Profiles.

Barrios, Juliana
Ai, Xingbin

PMID: 30571139; PMCID: PMC6543741; DOI: 10.1165/rcmb.2018-0179OC;

Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S. Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways. PLoS One. 2019; 14(4):e0213831. PMID: 30964887; PMCID: PMC6456176; DOI: 10.1371/journal.pone.0213831;

Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods. 2018 11; 15(11):889-899.View Related Profiles.

Cardoso, Wellington
Ai, Xingbin

PMID: 30377379; PMCID: PMC6214364; DOI: 10.1038/s41592-018-0189-6;

Barrios J, Ai X. Neurotrophins in Asthma. Curr Allergy Asthma Rep. 2018 02 16; 18(2):10.View Related Profiles.

Barrios, Juliana
Ai, Xingbin

PMID: 29453651; PMCID: PMC5931370; DOI: 10.1007/s11882-018-0765-y;

Buttrick TS, Wang W, Yung C, Trieu KG, Patel K, Khoury SJ, Ai X, Elyaman W. Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy. Sci Rep. 2018 01 16; 8(1):818. PMID: 29339772; PMCID: PMC5770389; DOI: 10.1038/s41598-018-19315-z;

Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles.

Labadorf, Adam
Fine, Alan
Szymaniak, Aleksander
Chen, Felicia
Wasserman, Gregory
Mizgerd, Joseph
Yamamoto, Kazuko
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Varelas, Xaralabos
Ai, Xingbin

PMID: 28920925; PMCID: PMC5617666; DOI: 10.1172/JCI94639;

Patel KR, Bai Y, Trieu KG, Barrios J, Ai X. Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma. FASEB J. 2017 Oct; 31(10):4335-4346.View Related Profiles.

Barrios, Juliana
Patel, Kruti
Ai, Xingbin

PMID: 28619712; PMCID: PMC5602904; DOI: 10.1096/fj.201700186R;

Jiang Z, Knudsen NH, Wang G, Qiu W, Naing ZZC, Bai Y, Ai X, Lee CH, Zhou X. Genetic Control of Fatty Acid ß-Oxidation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2017 Jun; 56(6):738-748. PMID: 28199134; PMCID: PMC5516290; DOI: 10.1165/rcmb.2016-0282OC;

Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 Sep; 31(9):4117-4128.View Related Profiles.

Barrios, Juliana
Patel, Kruti
Minns, Martin
Trinkaus-Randall, Vickery
Ai, Xingbin
Lee, Yoonjoo

PMID: 28566470; PMCID: PMC5572694; DOI: 10.1096/fj.201700115R;

Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists. Am J Respir Cell Mol Biol. 2016 May; 54(5):656-63.View Related Profiles.

Patel, Kruti
Ai, Xingbin

PMID: 26550921; PMCID: PMC4942196; DOI: 10.1165/rcmb.2015-0290MA;

Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016 Nov; 9(6):1466-1476.View Related Profiles.

Patel, Kruti
Ai, Xingbin

PMID: 26860818; PMCID: PMC4980297; DOI: 10.1038/mi.2016.11;

Jiang Z, Cushing L, Ai X, Lü J. miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):273-83.View Related Profiles.

Lu, Jining
Cushing, Leah
Ai, Xingbin
Jiang, Zhihua

PMID: 24617895; PMCID: PMC4148035; DOI: 10.1165/rcmb.2013-0127OC;

Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81.View Related Profiles.

Fine, Alan
Paez-Cortez, Jesus
Ai, Xingbin

PMID: 24313705; PMCID: PMC4068941; DOI: 10.1165/rcmb.2013-0166MA;

Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907.View Related Profiles.

Fine, Alan
Paez-Cortez, Jesus
Cruikshank, William
Ai, Xingbin

PMID: 24221086; PMCID: PMC3898648; DOI: 10.1096/fj.13-238212;

Dixit R, Ai X, Fine A. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov; 140(21):4398-406.View Related Profiles.

Fine, Alan
Ai, Xingbin

PMID: 24130328; PMCID: PMC4007715; DOI: 10.1242/dev.098079;

Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469.View Related Profiles.

Fine, Alan
Paez-Cortez, Jesus
Lu, Jining
Patel, Kruti
Ai, Xingbin

PMID: 24040256; PMCID: PMC3767675; DOI: 10.1371/journal.pone.0074469;

Aven L, Ai X. Mechanisms of respiratory innervation during embryonic development. Organogenesis. 2013 Jul-Sep; 9(3):194-8. PMID: 23974176; PMCID: PMC3896590; DOI: 10.4161/org.24842;

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6.View Related Profiles.

Cardoso, Wellington
Ai, Xingbin

PMID: 23607856; PMCID: PMC3955361; DOI: 10.1513/AnnalsATS.201207-036OT;

Tran TH, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012 Sep 21; 287(39):32651-64.View Related Profiles.

Zaia, Joseph
Tran, Thanh
Shi, Xiaofeng
Ai, Xingbin

PMID: 22865881; PMCID: PMC3463311; DOI: 10.1074/jbc.M112.353243;

Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87.View Related Profiles.

Chui, David
Lu, Jining
Cardoso, Wellington
Ai, Xingbin
Jiang, Zhihua

PMID: 22187428; PMCID: PMC3285365; DOI: 10.1074/jbc.M111.297937;

Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15.View Related Profiles.

Fine, Alan
Paez-Cortez, Jesus
Lu, Jining
Tran, Thanh
Ai, Xingbin
Jiang, Zhihua

PMID: 22031887; PMCID: PMC3222097; DOI: 10.1523/JNEUROSCI.2745-11.2011;

Schumacher VA, Schlötzer-Schrehardt U, Karumanchi SA, Shi X, Zaia J, Jeruschke S, Zhang D, Pavenstädt H, Pavenstaedt H, Drenckhan A, Amann K, Ng C, Hartwig S, Ng KH, Ho J, Kreidberg JA, Taglienti M, Royer-Pokora B, Ai X. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96.View Related Profiles.

Zaia, Joseph
Ai, Xingbin

PMID: 21719793; PMCID: PMC3137576; DOI: 10.1681/ASN.2010080860;

Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87.View Related Profiles.

Fine, Alan
Paez-Cortez, Jesus
Ghosh, Shamik
Cardoso, Wellington
Ai, Xingbin

PMID: 21536678; PMCID: PMC3121411; DOI: 10.1074/jbc.M111.241224;

Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61.View Related Profiles.

Fine, Alan
Zaia, Joseph
Tran, Thanh
Shi, Xiaofeng
Ai, Xingbin

PMID: 20855470; PMCID: PMC3031337; DOI: 10.1093/glycob/cwq133;

Langsdorf A, Radzikinas K, Kroten A, Jain S, Ai X. Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):293-301. PMID: 20139349; PMCID: PMC3159091; DOI: 10.1165/rcmb.2009-0462OC;

Ambasta RK, Ai X, Emerson CP. Quail Sulf1 function requires asparagine-linked glycosylation. J Biol Chem. 2007 Nov 23; 282(47):34492-9. PMID: 17855356

Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP, Ai X. Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. Dev Biol. 2007 Nov 15; 311(2):464-77. PMID: 17920055

Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 2007 Sep; 134(18):3327-38. PMID: 17720696

Danesin C, Agius E, Escalas N, Ai X, Emerson C, Cochard P, Soula C. Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J Neurosci. 2006 May 10; 26(19):5037-48. PMID: 16687495; PMCID: PMC6674256; DOI: 10.1523/JNEUROSCI.0715-06.2006;

Riobó NA, Lu K, Ai X, Haines GM, Emerson CP. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4505-10. PMID: 16537363; PMCID: PMC1450201; DOI: 10.1073/pnas.0504337103;

Ai X, Do AT, Kusche-Gullberg M, Lindahl U, Lu K, Emerson CP. Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2. J Biol Chem. 2006 Feb 24; 281(8):4969-76. PMID: 16377625

Braquart-Varnier C, Danesin C, Clouscard-Martinato C, Agius E, Escalas N, Benazeraf B, Ai X, Emerson C, Cochard P, Soula C. A subtractive approach to characterize genes with regionalized expression in the gliogenic ventral neuroepithelium: identification of chick sulfatase 1 as a new oligodendrocyte lineage gene. Mol Cell Neurosci. 2004 Apr; 25(4):612-28. PMID: 15080891

Wang S, Ai X, Freeman SD, Pownall ME, Lu Q, Kessler DS, Emerson CP. QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4833-8. PMID: 15051888; PMCID: PMC387334

Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP. QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J Cell Biol. 2003 Jul 21; 162(2):341-51. PMID: 12860968; PMCID: PMC2172803

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 19 distinct years, with a maximum of 6 publications in 2023