Xingbin Ai, PhD
Adjunct Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

PhD, Case Western Reserve University




Expertise and interests include:

REGULATION OF STEM CELL FUNCTION AND AGING BY HEPARAN SULFATE AND SULFS:
Environmental signals play crucial roles in self-renewal of stem cells, tissue regeneration and aging. Ai lab investigates heparan sulfate-dependent mechanisms that regulate extracellular signaling during stem cell maintenance and regeneration of the skeletal muscle. Our study is focused on two heparan sulfate-modifying enzymes called Sulfs.

NEUROGENESIS AND NEUROPLASTICITY IN PULMONARY DISEASES:
The respiratory tract is known to be innervated by two groups of neurons. The intrinsic neurons have cell bodies located within the tissue, while the extrinsic neurons have their cell bodies located in the central and peripheral nervous system and their axons innervating airway smooth muscle and neuroendocrine cells. Ai lab investigates neurotrophic signals that regulate neurogenesis in developing lung and neuroplasticity in pulmonary diseases. Our goal is to understand physiological roles of neural innervation in respiratory function, diseases and regeneration.

AIRWAY SMOOTH MUSCLE DEVELOPMENT AND REMODELING IN ASTHMA:
Airway smooth muscle hyperplasia and hyper-reactivity are key features of asthma. Ai lab, in collaboration with Dr. Alan Fine’s lab, investigates mechanisms underlying the formation and remodeling of airway smooth muscle. We are particularly interested in the sonic hedgehog pathway in control of airway smooth muscle development.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




The Fetal Lung Mesothelial Differentiation Program
08/05/2013 - 05/31/2017 (Co-Investigator of Sub-Project / SP)
PI: Alan Fine, MD
NIH/National Heart, Lung, and Blood Institute
5R01HL116163-03

Identifying the Molecular Phenotype of Normal and Asthmatic Bronchial Smooth Muscle
01/01/2012 - 12/31/2015 (Multi-PI)
PI: Xingbin Ai, PhD
NIH/National Heart, Lung, and Blood Institute
5R21HL112619-02

Linking Increased Innervation to Persistent BSM Hyper-reactivity
07/01/2012 - 06/30/2015 (PI)
American Asthma Foundation


Identification of Sulfs as Therapeutic Targets for the Treatment of Age-Impaired Skeletal Muscle Regeneration
03/15/2010 - 07/31/2014 (PI)
NIH/National Institute on Aging
5R01AG034939-05



Title


Yr Title Project-Sub Proj Pubs
2021 Age-related mechanisms of T helper 2 memory in the early lung 1R01HL154549-01A1
2020 Development of PNEC innervation and neuroplasticity after early life insult 7R01HL132991-04 7
2019 Development of PNEC innervation and neuroplasticity after early life insult 5R01HL132991-03 7
2018 Development of PNEC innervation and neuroplasticity after early life insult 5R01HL132991-02 7
2017 Development of PNEC innervation and neuroplasticity after early life insult 1R01HL132991-01A1 7
2016 The Fetal Lung Mesothelial Differentiation Program 4R01HL116163-04 13
2015 The Fetal Lung Mesothelial Differentiation Program 5R01HL116163-03 13
2014 Identification of Sulfs as therapeutic targets for the treatment of age-impaired skeletal muscle regeneration 7R01AG034939-06 4
2014 The Fetal Lung Mesothelial Differentiation Program 5R01HL116163-02 13
2014 Identification of Sulfs as therapeutic targets for the treatment of age-impaired 5R01AG034939-05 4
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Bai Y, Ai X. Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle. J Vis Exp. 2022 May 05; (183). PMID: 35604150
     
  2. Bai Y, Guedes AGP, Krishnan R, Ai X. CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility. J Allergy Clin Immunol. 2022 May; 149(5):1643-1654.e8. PMID: 34800431; PMCID: PMC9081122; DOI: 10.1016/j.jaci.2021.10.033;
     
  3. Wang W, Ai X. Primary culture of immature, naïve mouse CD4+ T cells. STAR Protoc. 2021 Sep 17; 2(3):100756. PMID: 34430922; PMCID: PMC8369069; DOI: 10.1016/j.xpro.2021.100756;
     
  4. Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347.View Related Profiles. PMID: 34260916; PMCID: PMC8346236; DOI: 10.1016/j.celrep.2021.109347;
     
  5. Shui JE, Wang W, Liu H, Stepanova A, Liao G, Qian J, Ai X, Ten V, Lu J, Cardoso WV. Prematurity alters the progenitor cell program of the upper respiratory tract of neonates. Sci Rep. 2021 05 24; 11(1):10799.View Related Profiles. PMID: 34031475; PMCID: PMC8144386; DOI: 10.1038/s41598-021-90093-x;
     
  6. Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 04 20; 35(3):109011.View Related Profiles. PMID: 33882306; PMCID: PMC8140387; DOI: 10.1016/j.celrep.2021.109011;
     
  7. Lu RA, Zeki AA, Ram-Mohan S, Nguyen N, Bai Y, Chmiel K, Pecic S, Ai X, Krishnan R, Ghosh CC. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins. Front Pharmacol. 2020; 11:469. PMID: 32435188; PMCID: PMC7218099; DOI: 10.3389/fphar.2020.00469;
     
  8. Li G, Cohen JA, Martines C, Ram-Mohan S, Brain JD, Krishnan R, Ai X, Bai Y. Preserving Airway Smooth Muscle Contraction in Precision-Cut Lung Slices. Sci Rep. 2020 04 15; 10(1):6480. PMID: 32296115; PMCID: PMC7160136; DOI: 10.1038/s41598-020-63225-y;
     
  9. Ram-Mohan S, Bai Y, Schaible N, Ehrlicher AJ, Cook DP, Suki B, Stoltz DA, Solway J, Ai X, Krishnan R. Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L323-L330.View Related Profiles. PMID: 31774304; PMCID: PMC7052683; DOI: 10.1152/ajplung.00297.2019;
     
  10. Wang W, Cohen JA, Wallrapp A, Trieu KG, Barrios J, Shao F, Krishnamoorthy N, Kuchroo VK, Jones MR, Fine A, Bai Y, Ai X. Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Immunity. 2019 12 17; 51(6):1102-1118.e7.View Related Profiles. PMID: 31757673; PMCID: PMC6937208; DOI: 10.1016/j.immuni.2019.10.002;
     
Showing 10 of 45 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 45 publications over 17 distinct years, with a maximum of 5 publications in 2013 and 2019 and 2021

YearPublications
20031
20042
20051
20062
20073
20102
20114
20121
20135
20142
20162
20174
20183
20195
20202
20215
20221
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

developmental biology
heparan sulfate
neurobiology
neuroscience
skeletal muscle regeneration
stem cell biology
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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