Paul Toselli, MD, PhD
Associate Emeritus Professor
Boston University School of Medicine
Dept of Biochemistry

MD, Hahnemann Medical College
PhD, University of Pennsylvania

During my time at BUSM, I have taught medical students in anatomy, physiology, and pathology courses. Over the past seven years, I have participated in teaching GMS BI 555/755, a biochemistry course open to graduate students from all basic science departments. In this course, I teach fundamental concepts and practical applications of light and electron microscopy for experimental research. My instruction ranges from classical histological techniques perfected in the nineteenth century to the most recent developments in immunohistochemistry and histomorphology, including TUNEL assays and in situ hybridization. I teach the students the concepts behind each technique and its application to experimental questions they are likely to face, and also give them the tools to make their own critical evaluation of data generated by these methods.
In addition to formal lectures and associated classroom teaching, I have provided individualized instruction to graduate students, postdocs, technicians, undergraduates, special students, fellow faculty members, and visiting scientists in my laboratory. Over the years there have been literally hundreds of such instances, from brief consultations of few minutes in duration to collaborative efforts spanning years. I have given freely of my time to all who have entered my lab with experimental questions that could be answered by the anatomical and related techniques at my disposal. I have concentrated my efforts on helping graduate students and postdocs in the Biochemistry department. My help has included everything from tissue preparation to photography for publication. I have spent an enormous amount of time and effort teaching people how to fix, embed, section, and image tissue from experimental animals, cultured cells, and human samples. I have taught students at various levels how best to use fluorescent, phase-contrast, and polarizing light microscopes, and this has extended to electron microscopy, both transmission and scanning. I developed and perfected in situ hybridization techniques with one set of students and faculty members, and then made my expertise in this technology available to subsequent lab groups who needed it. I have made critical contributions of this nature to the thesis work of a dozen doctoral candidates in the Biochemistry department alone in the past seven years. I have also taught, trained, and guided postdocs, master students, students from CityLab, and technicians.
In addition, I employed the electron microscope to detect and localize beta-galactosidase expression in lung tissue, vascular tissue, and platelets. The introduction of the electron microscope to precisely localize beta-galactosidase expression demonstrates a highly innovative scientific approach that I introduced to the Biochemistry Department faculty and to Ph.D. candidates.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Boston Medical Center

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501.View Related Profiles. PMID: 26755713; PMCID: PMC4797025; DOI: 10.1182/blood-2015-02-629667;.
  2. Zhao Y, Kumbrink J, Lin BT, Bouton AH, Yang S, Toselli PA, Kirsch KH. Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis. 2013 Dec; 34(12):2880-90.View Related Profiles. PMID: 23825155; PMCID: PMC3845889; DOI: 10.1093/carcin/bgt238;.
  3. Biasini E, Unterberger U, Solomon IH, Massignan T, Senatore A, Bian H, Voigtlaender T, Bowman FP, Bonetto V, Chiesa R, Luebke J, Toselli P, Harris DA. A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity. J Neurosci. 2013 Feb 6; 33(6):2408-18.View Related Profiles. PMID: 23392670; PMCID: PMC3711660; DOI: 10.1523/JNEUROSCI.3406-12.2013;.
  4. Bergethon PR, Kindler DD, Hallock K, Blease S, Toselli P. Continuous exposure to low amplitude extremely low frequency electrical fields characterizing the vascular streaming potential alters elastin accumulation in vascular smooth muscle cells. Bioelectromagnetics. 2013 Jul; 34(5):358-65.View Related Profiles. PMID: 23322407; DOI: 10.1002/bem.21777;.
  5. Gao S, Zhou J, Zhao Y, Toselli P, Li W. Hypoxia-response element (HRE)-directed transcriptional regulation of the rat lysyl oxidase gene in response to cobalt and cadmium. Toxicol Sci. 2013 Apr; 132(2):379-89.View Related Profiles. PMID: 23161664; PMCID: PMC3595521; DOI: 10.1093/toxsci/kfs327;.
  6. Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci. 2013 Mar; 70(5):893-908.View Related Profiles. PMID: 23052206; PMCID: PMC3696992; DOI: 10.1007/s00018-012-1154-7;.
  7. Yu J, Taylor L, Rich C, Toselli P, Stone P, Green D, Warburton R, Hill N, Goldstein R, Polgar P. Transgenic expression of an altered angiotensin type I AT1 receptor resulting in marked modulation of vascular type I collagen. J Cell Physiol. 2012 May; 227(5):2013-21.View Related Profiles. PMID: 21751211; PMCID: PMC3247653; DOI: 10.1002/jcp.22929;.
  8. Zhao Y, Toselli P, Li W. Microtubules as a critical target for arsenic toxicity in lung cells in vitro and in vivo. Int J Environ Res Public Health. 2012 Feb; 9(2):474-95.View Related Profiles. PMID: 22470304; PMCID: PMC3315258; DOI: 10.3390/ijerph9020474;.
  9. Dominguez I, Degano IR, Chea K, Cha J, Toselli P, Seldin DC. CK2a is essential for embryonic morphogenesis. Mol Cell Biochem. 2011 Oct; 356(1-2):209-16.View Related Profiles. PMID: 21761203; PMCID: PMC3756899; DOI: 10.1007/s11010-011-0961-8;.
  10. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27.View Related Profiles. PMID: 20102488; DOI: 10.1111/j.1538-7836.2010.03769.x;.
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This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 28 distinct years, with a maximum of 7 publications in 2007

Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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