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Last Name

Tania Massignan

TitlePostdoctoral Fellow
InstitutionBoston University School of Medicine
Phone(617) 638-4117
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E. A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein. Sci Rep. 2016; 6:23180. PMID: 26976106.
    View in: PubMed
  2. Lauranzano E, Pozzi S, Pasetto L, Stucchi R, Massignan T, Paolella K, Mombrini M, Nardo G, Lunetta C, Corbo M, Mora G, Bendotti C, Bonetto V. Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes. Brain. 2015 Apr; 138(Pt 4):974-91. PMID: 25678563.
    View in: PubMed
  3. Biasini E, Unterberger U, Solomon IH, Massignan T, Senatore A, Bian H, Voigtlaender T, Bowman FP, Bonetto V, Chiesa R, Luebke J, Toselli P, Harris DA. A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity. J Neurosci. 2013 Feb 6; 33(6):2408-18. PMID: 23392670.
    View in: PubMed
  4. Turnbaugh JA, Unterberger U, SaĆ” P, Massignan T, Fluharty BR, Bowman FP, Miller MB, Supattapone S, Biasini E, Harris DA. The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc). J Neurosci. 2012 Jun 27; 32(26):8817-30. PMID: 22745483.
    View in: PubMed
  5. Biasini E, Turnbaugh JA, Massignan T, Veglianese P, Forloni G, Bonetto V, Chiesa R, Harris DA. The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells. PLoS One. 2012; 7(3):e33472. PMID: 22428057.
    View in: PubMed
  6. Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, La Rosa S, Finzi G, Bonetto V, Bertuzzi F, Maechler P, Massa O. Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E. Acta Diabetol. 2013 Feb; 50(1):61-72. PMID: 22382775.
    View in: PubMed
  7. Solomon IH, Khatri N, Biasini E, Massignan T, Huettner JE, Harris DA. An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity. J Biol Chem. 2011 Apr 22; 286(16):14724-36. PMID: 21385869.
    View in: PubMed
  8. Massignan T, Biasini E, Harris DA. A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide. Methods. 2011 Mar; 53(3):214-9. PMID: 21115124.
    View in: PubMed
  9. Biasini E, Tapella L, Restelli E, Pozzoli M, Massignan T, Chiesa R. The hydrophobic core region governs mutant prion protein aggregation and intracellular retention. Biochem J. 2010 Sep 15; 430(3):477-86. PMID: 20626348.
    View in: PubMed
  10. Massignan T, Biasini E, Lauranzano E, Veglianese P, Pignataro M, Fioriti L, Harris DA, Salmona M, Chiesa R, Bonetto V. Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway. Mol Cell Proteomics. 2010 Apr; 9(4):611-22. PMID: 19996123.
    View in: PubMed
  11. Basso M, Samengo G, Nardo G, Massignan T, D'Alessandro G, Tartari S, Cantoni L, Marino M, Cheroni C, De Biasi S, Giordana MT, Strong MJ, Estevez AG, Salmona M, Bendotti C, Bonetto V. Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis. PLoS One. 2009; 4(12):e8130. PMID: 19956584.
    View in: PubMed
  12. Massignan T, Stewart RS, Biasini E, Solomon IH, Bonetto V, Chiesa R, Harris DA. A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein. J Biol Chem. 2010 Mar 5; 285(10):7752-65. PMID: 19940127.
    View in: PubMed
  13. Massignan T, Casoni F, Basso M, Stefanazzi P, Biasini E, Tortarolo M, Salmona M, Gianazza E, Bendotti C, Bonetto V. Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse. Biochem Biophys Res Commun. 2007 Feb 16; 353(3):719-25. PMID: 17196550.
    View in: PubMed
  14. Laragione T, Gianazza E, Tonelli R, Bigini P, Mennini T, Casoni F, Massignan T, Bonetto V, Ghezzi P. Regulation of redox-sensitive exofacial protein thiols in CHO cells. Biol Chem. 2006 Oct-Nov; 387(10-11):1371-6. PMID: 17081109.
    View in: PubMed
  15. Basso M, Massignan T, Samengo G, Cheroni C, De Biasi S, Salmona M, Bendotti C, Bonetto V. Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice. J Biol Chem. 2006 Nov 3; 281(44):33325-35. PMID: 16943203.
    View in: PubMed
  16. Biasini E, Massignan T, Fioriti L, Rossi V, Dossena S, Salmona M, Forloni G, Bonetto V, Chiesa R. Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity. Proteomics. 2006 May; 6(9):2823-34. PMID: 16572473.
    View in: PubMed
  17. Ghezzi P, Casagrande S, Massignan T, Basso M, Bellacchio E, Mollica L, Biasini E, Tonelli R, Eberini I, Gianazza E, Dai WW, Fratelli M, Salmona M, Sherry B, Bonetto V. Redox regulation of cyclophilin A by glutathionylation. Proteomics. 2006 Feb; 6(3):817-25. PMID: 16372262.
    View in: PubMed
  18. Casoni F, Basso M, Massignan T, Gianazza E, Cheroni C, Salmona M, Bendotti C, Bonetto V. Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis. J Biol Chem. 2005 Apr 22; 280(16):16295-304. PMID: 15699043.
    View in: PubMed
  19. Fioriti L, Quaglio E, Massignan T, Colombo L, Stewart RS, Salmona M, Harris DA, Forloni G, Chiesa R. The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species. Mol Cell Neurosci. 2005 Jan; 28(1):165-76. PMID: 15607951.
    View in: PubMed
  20. Laragione T, Bonetto V, Casoni F, Massignan T, Bianchi G, Gianazza E, Ghezzi P. Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):14737-41. PMID: 14657342.
    View in: PubMed
  21. Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, Diomede L, Thaler F, Mollica L, Musco G, Kourie JJ, Bugiani O, Sharma D, Inouye H, Kirschner DA, Forloni G, Tagliavini F. Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein. J Biol Chem. 2003 Nov 28; 278(48):48146-53. PMID: 12970341.
    View in: PubMed
  22. Casagrande S, Bonetto V, Fratelli M, Gianazza E, Eberini I, Massignan T, Salmona M, Chang G, Holmgren A, Ghezzi P. Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9745-9. PMID: 12119401.
    View in: PubMed
  23. Bonetto V, Massignan T, Chiesa R, Morbin M, Mazzoleni G, Diomede L, Angeretti N, Colombo L, Forloni G, Tagliavini F, Salmona M. Synthetic miniprion PrP106. J Biol Chem. 2002 Aug 30; 277(35):31327-34. PMID: 12058037.
    View in: PubMed
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