Jerome S. Brody, MD
Emeritus Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Illinois




Dr. Jerry Brody is Professor Emeritus of Medicine in Pulmonary, Allergy, Sleep & Critical Care at Boston University School of Medicine- Pulmonary Center. He was the longest serving Director of the Pulmonary Center, overseeing its growth and accomplishments for over 30 years. Dr. Brody has a scientific passion for lung development and has made many seminal contributions relating to cigarette smoking-induced lung disease, including lung cancer and COPD.

His research special interests include:
-Genomics of smoking-related lung diseases
-Lung cancer diagnostic/prognostic tools
-Genomics and the pathogenesis of COPD
-Developmental biology of the lung
-Relation of lung cancer to lung development

Dr. Brody's research includes using a variety of genomic tools to determine: 1) how the lung protects itself from the toxic effects of cigarette smoke; 2) why some smokers develop COPD and/or lung cancer while others are disease-free; 3) how we can use these new tools to define molecular pathways leading to each disease; 4) develop tests for the early diagnosis of lung cancer and for assessing a smokers’ risk of developing lung cancer; 5) and develop new approaches to therapy.

Boston Medical Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Emeritus Professor
Boston University School of Medicine
Medicine
Computational Biomedicine



Tobacco, Cancer and Epithelial Gene Expression
07/01/2003 - 06/30/2007 (Co-PI)
Doris Duke Charitable Foundation

Metastatic Progression of Breast Cancer by Allelic Loss on Chromosome 18q21
09/01/2001 - 08/31/2005 (Co-PI)
PI: Sam Thiagalingam, PhD
Department of Defense/Army

Genetic Determinants of Epithelial DNA Damage in Smokers
09/30/2001 - 06/30/2005 (Co-PI)
NIH/National Institute of Environmental Health Sciences
1 R01 ES10377 01A2

Airway Epithelial Expression in COPD
09/30/2002 - 08/31/2004 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL71771 02

Cigarette Smoke and Mouse Models of Human Lung Cancer
09/30/1999 - 03/31/2001 (PI)
Massachusetts Institute of Technology NIH NCI


Microsensor Arrays for Salivary Diagnostics
09/01/2006 - 02/28/2013 (PI)
Tufts University NIH-NIDCR


Title


Yr Title Project-Sub Proj Pubs
2009 Field of Injury Based Biomarkers for Lung Cancer 1R44CA139803-01A1 1
2003 Airway Epithelial Gene Expression in COPD 5R01HL071771-02 4
2002 Airway Epithelial Gene Expression in COPD 1R01HL071771-01 4
2001 POCKET PROTEIN/E2F REGULATES LUNG CELL DIFFERENTIATION 5P01HL047049-10-4 92
2001 REGULATION OF ALVEOLAR EPITHELIAL CELL DIFFERENTIATION 5P01HL047049-10 92
2000 POCKET PROTEIN/E2F REGULATES LUNG CELL DIFFERENTIATION 5P01HL047049-09-4 92
2000 REGULATION OF ALVEOLAR EPITHELIAL CELL DIFFERENTIATION 5P01HL047049-09 92
2000 BIOLOGY OF THE LUNG: A MULTIDISCIPLINARY PROGRAM 5T32HL007035-25 121
1999 POCKET PROTEIN/E2F REGULATES LUNG CELL DIFFERENTIATION 5P01HL047049-08-4 92
1999 REGULATION OF ALVEOLAR EPITHELIAL CELL DIFFERENTIATION 5P01HL047049-08 92
Showing 10 of 46 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A. A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. N Engl J Med. 2015 Jul 16; 373(3):243-51.View Related Profiles. PMID: 25981554; DOI: 10.1056/NEJMoa1504601;
     
  2. Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. BMC Med Genomics. 2015; 8:18.View Related Profiles. PMID: 25944280; PMCID: PMC4434538; DOI: 10.1186/s12920-015-0091-3;
     
  3. Kathuria H, Gesthalter Y, Spira A, Brody JS, Steiling K. Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention. Cancers (Basel). 2014; 6(2):1157-79.View Related Profiles. PMID: 24840047; DOI: 10.3390/cancers6021157;
     
  4. Senior RM, Brody JS, Williams MC. The Red journal at 25. A perspective from the founding editors. Am J Respir Cell Mol Biol. 2014 May; 50(5):840-1. PMID: 24783953; DOI: 10.1165/rcmb.2014-0105ED;
     
  5. Brody JS. The promise and problems of e-cigarettes. Am J Respir Crit Care Med. 2014 Feb 15; 189(4):379-80. PMID: 24528311; DOI: 10.1164/rccm.201312-2263ED;
     
  6. Brody JS. Transcriptome alterations induced by cigarette smoke. Int J Cancer. 2012 Dec 15; 131(12):2754-62. PMID: 22961494; DOI: 10.1002/ijc.27829;
     
  7. Brody JS, Steiling K. Interaction of cigarette exposure and airway epithelial cell gene expression. Annu Rev Physiol. 2011; 73:437-56.View Related Profiles. PMID: 21090967; DOI: 10.1146/annurev-physiol-012110-142219;
     
  8. Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2010 Apr 7; 2(26):26ra25.View Related Profiles. PMID: 20375364; PMCID: PMC3694402; DOI: 10.1126/scitranslmed.3000251;
     
  9. Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. PLoS One. 2009; 4(4):e5043.View Related Profiles. PMID: 19357784; PMCID: PMC2664466; DOI: 10.1371/journal.pone.0005043;
     
  10. Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24.View Related Profiles. PMID: 19168627; PMCID: PMC2650144; DOI: 10.1073/pnas.0806383106;
     
Showing 10 of 116 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 83 publications over 34 distinct years, with a maximum of 7 publications in 1988

YearPublications
19801
19814
19822
19832
19844
19854
19861
19872
19887
19894
19905
19912
19923
19931
19942
19955
19963
19971
19981
19992
20011
20021
20034
20044
20051
20061
20073
20082
20092
20101
20111
20121
20143
20152

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

lung development
lung genomics
smoking and lung cancer
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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