Sam Thiagalingam | Profiles RNS

Sam Thiagalingam, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Biomedical Genetics

PhD, Johns Hopkins University
MS, Bowling Green State University
BSc, University of Jaffna

Websites

	Biomedical Genetics
	Systems Biology of Cancer
	Addgene
	SDPR-Epigenetically regulated metastasis suppressor gene
	Oncogenic mTORC2 pathway is a therapeutic target in colon cancer
	Psychiatric Epigenetics

ORCID : 0000-0001-5211-266X

Dr. Thiagalingam is an expert cancer geneticist and was the first to show that SMAD4 inactivation is a critical event during the late stages of colon cancer progression. He was a lead researcher in the team that first identified a family of five novel SMAD genes. He also proposed a simple minded multi-modular molecular network (MMMN) cancer progression model as a road map to visualize the various gene alterations in modules of networks of pathways. Recently, his studies found that intact hyperactive TGFß-Smad signaling is required to sustain “epigenetic memory” responsible for epithelial-mesenchymal transition (EMT), a critical step during conversion to malignant cancer. His long-term goal is to identify novel cancer biomarkers and therapeutic targets by contributing to the “big picture” of interconnected network of events that mediate cancer progression to metastasis using breast and colon cancers as the model systems. In addition to studying the various aspects of cancer, Dr. Thiagalingam has also been interested in taking an interdisciplinary approach to studying epigenomics of other complex diseases such as schizophrenia (SCZ) and bipolar disorder (BD). Recent studies by the lab found that there is asymmetric expression of many genes involved in the TGFB super family signaling pathways and those known to establish left-right asymmetry in SCZ and BD. Research efforts are ongoing to correlate epigenomic alterations in SCZ and BD to pathogenesis to identify effective therapeutic targets and agents.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor Signal Transduction Pathway Using Plasmon Coupling
04/01/2020 - 03/31/2026 (Co-Investigator)
PI: Bjorn Reinhard, Dr. rer. nat.
NIH/National Cancer Institute
5R01CA138509-15

Dissecting the metastasis suppressor complex to identify colon cancer biomarkers
03/01/2013 - 02/29/2016 (PI)
NIH/National Cancer Institute
5R21CA165707-02

Identification and functional characterization of novel genes involved in breast cancer metastasis
12/01/2011 - 09/29/2013 (PI)
University of Cyprus

Identification and Functional Characterization of Novel Genes Involved in Breast Cancer Metastasis
12/01/2010 - 12/01/2012 (PI)
University of Cyprus Cyprus & EU Reg Dev

The Role of hBub1-p53 Pathway in Genomic Stability
08/01/2003 - 05/31/2009 (PI)
NIH/National Cancer Institute
5 R01 CA101773 05

Epigenetic Modulation of Serotonin Signaling in the Pathogenesis of Schizophrenia and Bipolar Disorder
09/15/2006 - 09/14/2008 (PI)
National Alliance for Research on Schizophrenia and Depressi

Genetic Determinants of Epithelial DNA Damage in Smokers
09/30/2001 - 12/31/2005 (PI)
NIH/National Institute of Environmental Health Sciences
5 R01 ES10377 04

Metastatic Progression of Breast Cancer by Allelic Loss on Chromosome 18q21
09/01/2001 - 08/31/2005 (PI)
Department of Defense/Army

A Model System For Molecular
07/01/1999 - 09/30/2002 (PI)
American Lung Asso

Hbub1 For P53 Inactivation
07/01/2000 - 06/30/2002 (PI)
Medical Foundation

Title

Yr	Title	Project-Sub Proj	Pubs
2014	Dissecting the metastasis suppressor complex to identify colon cancer biomarkers	5R21CA165707-02	8
2013	Dissecting the metastasis suppressor complex to identify colon cancer biomarkers	1R21CA165707-01A1	8
2007	The role of hBUB1-p53 pathway in genomic stability.	5R01CA101773-05	9
2006	The role of hBUB1-p53 pathway in genomic stability.	5R01CA101773-04	9
2005	The role of hBUB1-p53 pathway in genomic stability.	5R01CA101773-03	9
2004	The role of hBUB1-p53 pathway in genomic stability.	5R01CA101773-02	9
2004	Genetic Determinants of Epithelial DNA Damage in Smokers	5R01ES010377-04	11
2003	The role of hBUB1-p53 pathway in genomic stability.	1R01CA101773-01	9
2003	Genetic Determinants of Epithelial DNA Damage in Smokers	5R01ES010377-03	11
2002	Genetic Determinants of Epithelial DNA Damage in Smokers	5R01ES010377-02	11

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Nohesara S, Mostafavi Abdolmaleky H, Pirani A, Thiagalingam S. Epigenetics and Gut Microbiota in the Pathogenesis and Treatment of Bipolar Disorder (BD). Cells. 2025 Jul 18; 14(14). PMID: 40710357; PMCID: PMC12293998; DOI: 10.3390/cells14141104;

Nohesara S, Mostafavi Abdolmaleky H, Pirani A, Thiagalingam S. Therapeutic Horizons: Gut Microbiome, Neuroinflammation, and Epigenetics in Neuropsychiatric Disorders. Cells. 2025 Jul 04; 14(13). PMID: 40643545; PMCID: PMC12249038; DOI: 10.3390/cells14131027;

Nohesara S, Mostafavi Abdolmaleky H, Dickerson F, Pinto-Tomas AA, Jeste DV, Thiagalingam S. Corrigendum to "Associations of microbiome pathophysiology with social activity and behavior are mediated by epigenetic modulations: Avenues for designing innovative therapeutic strategies" [Neurosci. Biobehav. Rev. 174 (2025) 106208]. Neurosci Biobehav Rev. 2025 Aug; 175:106240. PMID: 40484738

Nohesara S, Mostafavi Abdolmaleky H, Dickerson F, Pinto-Tomas AA, Jeste DV, Thiagalingam S. Associations of microbiome pathophysiology with social activity and behavior are mediated by epigenetic modulations: Avenues for designing innovative therapeutic strategies. Neurosci Biobehav Rev. 2025 Jul; 174:106208. PMID: 40350003

Nohesara S, Mostafavi Abdolmaleky H, Pirani A, Pettinato G, Thiagalingam S. The Obesity-Epigenetics-Microbiome Axis: Strategies for Therapeutic Intervention. Nutrients. 2025 May 01; 17(9). PMID: 40362873; PMCID: PMC12073275; DOI: 10.3390/nu17091564;

Nohesara S, Mostafavi Abdolmaleky H, Pettinato G, Pirani A, Thiagalingam S, Zhou JR. IUPHAR review: Eating disorders, gut microbiota dysbiosis and epigenetic aberrations. Pharmacol Res. 2025 Mar; 213:107653. PMID: 39970995

Abdolmaleky HM, Nohesara S, Zhou JR, Thiagalingam S. Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment. Epigenomics. 2025 Apr; 17(5):317-333. PMID: 39948759; PMCID: PMC11970782; DOI: 10.1080/17501911.2025.2464529;

Nohesara S, Abdolmaleky HM, Dickerson F, Pinto-Tomás AA, Jeste DV, Thiagalingam S. Maternal Gut Microbiome-Mediated Epigenetic Modifications in Cognitive Development and Impairments: A New Frontier for Therapeutic Innovation. Nutrients. 2024 Dec 17; 16(24). PMID: 39770976; PMCID: PMC11676351; DOI: 10.3390/nu16244355;

Nohesara S, Mostafavi Abdolmaleky H, Thiagalingam S. Substance-Induced Psychiatric Disorders, Epigenetic and Microbiome Alterations, and Potential for Therapeutic Interventions. Brain Sci. 2024 Jul 30; 14(8). PMID: 39199463; PMCID: PMC11352452; DOI: 10.3390/brainsci14080769;

Abdolmaleky HM, Nohesara S, Thiagalingam S. Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses. Brain Sci. 2024 Mar 07; 14(3). PMID: 38539649; PMCID: PMC10968810; DOI: 10.3390/brainsci14030261;

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Nohesara S, Abdolmaleky HM, Thiagalingam S. Potential for New Therapeutic Approaches by Targeting Lactate and pH Mediated Epigenetic Dysregulation in Major Mental Diseases. Biomedicines. 2024 Feb 18; 12(2). PMID: 38398057; PMCID: PMC10887322; DOI: 10.3390/biomedicines12020457;

Nohesara S, Abdolmaleky HM, Zhou JR, Thiagalingam S. Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies. Genes (Basel). 2023 Dec 14; 14(12). PMID: 38137038; PMCID: PMC10742434; DOI: 10.3390/genes14122217;

Nohesara S, Abdolmaleky HM, Thiagalingam S, Zhou JR. Gut microbiota defined epigenomes of Alzheimer's and Parkinson's diseases reveal novel targets for therapy. Epigenomics. 2024 Jan; 16(1):57-77. PMID: 38088063; PMCID: PMC10804213; DOI: 10.2217/epi-2023-0342;

Nohesara S, Abdolmaleky HM, Thiagalingam S. Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations. Genes (Basel). 2023 Jul 24; 14(7). PMID: 37510410; PMCID: PMC10379841; DOI: 10.3390/genes14071506;

Abdolmaleky HM, Martin M, Zhou JR, Thiagalingam S. Epigenetic Alterations of Brain Non-Neuronal Cells in Major Mental Diseases. Genes (Basel). 2023 Apr 12; 14(4). PMID: 37107654; PMCID: PMC10137903; DOI: 10.3390/genes14040896;

Laroche FJF, Li S, Shen N, Hwang SK, Nguyen G, Yu W, Wong CK, Quinton RJ, Berman JN, Liu CT, Singh A, Ganem NJ, Thiagalingam S, Feng H. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 2023 Mar 23; 12(7).View Related Profiles.

Wong, Chen Khuan
Liu, Ching-Ti
Feng, Hui
Ganem, Neil
Quinton, Ryan
Thiagalingam, Sam

PMID: 37048053; PMCID: PMC10093541; DOI: 10.3390/cells12070980;

Chung J, Das A, Sun X, Sobreira DR, Leung YY, Igartua C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X, Jun GR, Stein TD, Kunkle BW, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, Nobrega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement. 2023 Mar; 19(3):896-908.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Thiagalingam, Sam
Stein, Thor
Zhang, Xiaoling

PMID: 35770850; PMCID: PMC9800643; DOI: 10.1002/alz.12719;

Abdolmaleky HM, Zhou JR, Thiagalingam S. Cataloging recent advances in epigenetic alterations in major mental disorders and autism. Epigenomics. 2021 08; 13(15):1231-1245. PMID: 34318684; PMCID: PMC8738978; DOI: 10.2217/epi-2021-0074;

Thiagalingam S. Epigenetic memory in development and disease: Unraveling the mechanism. Biochim Biophys Acta Rev Cancer. 2020 04; 1873(2):188349. PMID: 31982403; PMCID: PMC7225062; DOI: 10.1016/j.bbcan.2020.188349;

Wong CK, Lambert AW, Ozturk S, Papageorgis P, Lopez D, Shen N, Sen Z, Abdolmaleky HM, Gyorffy B, Feng H, Thiagalingam S. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Mol Cancer Res. 2020 03; 18(3):414-423.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Lopez, Delia
Feng, Hui
Shen, Ning
Thiagalingam, Sam

PMID: 31932471; PMCID: PMC7115128; DOI: 10.1158/1541-7786.MCR-19-0525;

Wong CK, Gromisch C, Ozturk S, Papageorgis P, Abdolmaleky HM, Reinhard BM, Thiagalingam A, Thiagalingam S. MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer. Cancer Biol Ther. 2019; 20(8):1113-1120.View Related Profiles.

Wong, Chen Khuan
Gromisch, Christopher
Thiagalingam, Sam

PMID: 30922194; PMCID: PMC6605987; DOI: 10.1080/15384047.2019.1595285;

Kalli M, Mpekris F, Wong CK, Panagi M, Ozturk S, Thiagalingam S, Stylianopoulos T, Papageorgis P. Activin A Signaling Regulates IL13Ra2 Expression to Promote Breast Cancer Metastasis. Front Oncol. 2019; 9:32. PMID: 30805303; PMCID: PMC6370707; DOI: 10.3389/fonc.2019.00032;

Abdolmaleky HM, Gower AC, Wong CK, Cox JW, Zhang X, Thiagalingam A, Shafa R, Sivaraman V, Zhou JR, Thiagalingam S. Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2019 03; 180(2):138-149.View Related Profiles.

Gower, Adam
Wong, Chen Khuan
Thiagalingam, Sam
Zhang, Xiaoling

PMID: 30468562; PMCID: PMC6386618; DOI: 10.1002/ajmg.b.32691;

Nohesara S, Ghadirivasfi M, Barati M, Ghasemzadeh MR, Narimani S, Mousavi-Behbahani Z, Joghataei M, Soleimani M, Taban M, Mehrabi S, Thiagalingam S, Abdolmaleky HM. Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes. Am J Med Genet B Neuropsychiatr Genet. 2016 Dec; 171(8):1180-1189. PMID: 27753212; PMCID: PMC7115129; DOI: 10.1002/ajmg.b.32506;

Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, Thiagalingam S. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):638-43.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Cohen, Herbert
Thiagalingam, Sam

PMID: 26739564; PMCID: PMC4725521; DOI: 10.1073/pnas.1514663113;

Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13.View Related Profiles.

Gower, Adam
Lambert, Arthur
Reinhard, Bjorn
Wong, Chen Khuan
Raghunathan, Rekha
Thiagalingam, Sam
Alekseyev, Yuriy

PMID: 26507575; PMCID: PMC4715959; DOI: 10.1158/1541-7786.MCR-15-0079;

Abdolmaleky HM, Pajouhanfar S, Faghankhani M, Joghataei MT, Mostafavi A, Thiagalingam S. Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post-mortem brain of patients with schizophrenia and Psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec; 168(8):687-96. PMID: 26285059; DOI: 10.1002/ajmg.b.32361;

Papageorgis P, Ozturk S, Lambert AW, Neophytou CM, Tzatsos A, Wong CK, Thiagalingam S, Constantinou AI. Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis. Breast Cancer Res. 2015; 17:98.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Thiagalingam, Sam

PMID: 26208975; PMCID: PMC4531803; DOI: 10.1186/s13058-015-0607-y;

Abdolmaleky HM, Zhou JR, Thiagalingam S. An update on the epigenetics of psychotic diseases and autism. Epigenomics. 2015; 7(3):427-49. PMID: 26077430; DOI: 10.2217/epi.14.85;

Abdolmaleky HM, Nohesara S, Ghadirivasfi M, Lambert AW, Ahmadkhaniha H, Ozturk S, Wong CK, Shafa R, Mostafavi A, Thiagalingam S. DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia. Schizophr Res. 2014 Feb; 152(2-3):373-80.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Thiagalingam, Sam

PMID: 24411530; PMCID: PMC7863587; DOI: 10.1016/j.schres.2013.12.007;

Lambert AW, Ozturk S, Thiagalingam S. Integrin signaling in mammary epithelial cells and breast cancer. ISRN Oncol. 2012; 2012:493283.View Related Profiles.

Lambert, Arthur
Thiagalingam, Sam

PMID: 22523705; PMCID: PMC3317013; DOI: 10.5402/2012/493283;

Abdolmaleky HM, Thiagalingam S. Can the schizophrenia epigenome provide clues for the molecular basis of pathogenesis? Epigenomics. 2011 Dec; 3(6):679-83. PMID: 22126286; DOI: 10.2217/epi.11.94;

Nohesara S, Ghadirivasfi M, Mostafavi S, Eskandari MR, Ahmadkhaniha H, Thiagalingam S, Abdolmaleky HM. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res. 2011 Nov; 45(11):1432-8. PMID: 21820670; DOI: 10.1016/j.jpsychires.2011.06.013;

Ghadirivasfi M, Nohesara S, Ahmadkhaniha HR, Eskandari MR, Mostafavi S, Thiagalingam S, Abdolmaleky HM. Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Jul; 156B(5):536-45. PMID: 21598376; DOI: 10.1002/ajmg.b.31192;

Abdolmaleky HM, Yaqubi S, Papageorgis P, Lambert AW, Ozturk S, Sivaraman V, Thiagalingam S. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res. 2011 Jul; 129(2-3):183-90.View Related Profiles.

Lambert, Arthur
Thiagalingam, Sam

PMID: 21550210; DOI: 10.1016/j.schres.2011.04.007;

Papageorgis P, Cheng K, Ozturk S, Gong Y, Lambert AW, Abdolmaleky HM, Zhou JR, Thiagalingam S. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res. 2011 Feb 1; 71(3):998-1008.View Related Profiles.

Lambert, Arthur
Thiagalingam, Sam

PMID: 21245094; PMCID: PMC3075468; DOI: 10.1158/0008-5472.CAN-09-3269;

Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010 Feb 1; 70(3):968-78.View Related Profiles.

Lambert, Arthur
Lenburg, Marc
Thiagalingam, Sam
Alekseyev, Yuriy

PMID: 20086175; PMCID: PMC2946209; DOI: 10.1158/0008-5472.CAN-09-1872;

Gao F, Ponte JF, Levy M, Papageorgis P, Cook NM, Ozturk S, Lambert AW, Thiagalingam A, Abdolmaleky HM, Sullivan BA, Thiagalingam S. hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation. Cancer Biol Ther. 2009 Apr; 8(7):548-56.View Related Profiles.

Lambert, Arthur
Thiagalingam, Sam

PMID: 19252416

Gao F, Ponte JF, Papageorgis P, Levy M, Ozturk S, Lambert AW, Pan H, Chinnappan D, Cheng KH, Thiagalingam A, Abdolmaleky HM, Thiagalingam S. hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells. Cancer Biol Ther. 2009 Apr; 8(7):627-35.View Related Profiles.

Lambert, Arthur
Thiagalingam, Sam

PMID: 19242126

Abdolmaleky HM, Zhou JR, Thiagalingam S, Smith CL. Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics. 2008 Dec; 9(12):1809-23. PMID: 19072640; DOI: 10.2217/14622416.9.12.1809;

Abdolmaleky HM, Smith CL, Zhou JR, Thiagalingam S. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Methods Mol Biol. 2008; 448:187-212. PMID: 18370235; DOI: 10.1007/978-1-59745-205-2_9;

Pan H, Gao F, Papageorgis P, Abdolmaleky HM, Faller DV, Thiagalingam S. Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression. Cancer Biol Ther. 2007 Oct; 6(10):1638-43.View Related Profiles.

Faller, Douglas
Thiagalingam, Sam

PMID: 18245958

Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, Smith CL, Shafa R, Aeali B, Carnevale J, Pan H, Papageorgis P, Ponte JF, Sivaraman V, Tsuang MT, Thiagalingam S. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet. 2006 Nov 1; 15(21):3132-45. PMID: 16984965; PMCID: PMC2799943; DOI: 10.1093/hmg/ddl253;

Thiagalingam S. A cascade of modules of a network defines cancer progression. Cancer Res. 2006 Aug 1; 66(15):7379-85. PMID: 16885330; PMCID: PMC2802460; DOI: 10.1158/0008-5472.CAN-06-0993;

Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M, Shafa R, Glatt SJ, Nguyen G, Ponte JF, Thiagalingam S, Tsuang MT. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5; 134B(1):60-6. PMID: 15717292

Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, Ponte JF, Chinnappan D, Nemani P, Sidransky D, Thiagalingam S. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res. 2005 Apr 1; 11(7):2466-70. PMID: 15814621

Pan H, Califano J, Ponte JF, Russo AL, Cheng KH, Thiagalingam A, Nemani P, Sidransky D, Thiagalingam S. Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. Cancer Res. 2005 Mar 1; 65(5):1664-9. PMID: 15753360

Abdolmaleky HM, Thiagalingam S, Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. Am J Pharmacogenomics. 2005; 5(3):149-60. PMID: 15952869

Cheng KH, Ponte JF, Thiagalingam S. Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display. Cancer Res. 2004 Mar 1; 64(5):1639-46. PMID: 14996722

Thiagalingam S, Cheng KH, Lee HJ, Mineva N, Thiagalingam A, Ponte JF. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann N Y Acad Sci. 2003 Mar; 983:84-100.View Related Profiles.

Lee, Hyunjoo
Thiagalingam, Sam

PMID: 12724214

Thiagalingam S, Foy RL, Cheng KH, Lee HJ, Thiagalingam A, Ponte JF. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Curr Opin Oncol. 2002 Jan; 14(1):65-72.View Related Profiles.

Lee, Hyunjoo
Thiagalingam, Sam

PMID: 11790983

Thiagalingam S, Laken S, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B, Lengauer C. Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2698-702. PMID: 11226302; PMCID: PMC30201

Thiagalingam S. Molecular detection of smad2/smad4 alterations in colorectal tumors. Methods Mol Med. 2001; 50:149-65. PMID: 21318824; DOI: 10.1385/1-59259-084-5:149;

Fink SP, Swinler SE, Lutterbaugh JD, Massagué J, Thiagalingam S, Kinzler KW, Vogelstein B, Willson JK, Markowitz S. Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res. 2001 Jan 1; 61(1):256-60. PMID: 11196171

Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim SJ, Kinzler KW, Vogelstein B, Willson JK, Markowitz S. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res. 1999 Jan 15; 59(2):320-4. PMID: 9927040

Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997 Dec; 1(1):3-11. PMID: 9659898

Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S. Frequency of Smad gene mutations in human cancers. Cancer Res. 1997 Jul 1; 57(13):2578-80. PMID: 9205057

He TC, da Costa LT, Thiagalingam S. Homeosis and polyposis: a tale from the mouse. Bioessays. 1997 Jul; 19(7):551-5. PMID: 9230687

Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet. 1996 Jul; 13(3):343-6. PMID: 8673134

Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Mad-related genes in the human. Nat Genet. 1996 Jul; 13(3):347-9. PMID: 8673135

Thiagalingam S, Lisitsyn NA, Hamaguchi M, Wigler MH, Willson JK, Markowitz SD, Leach FS, Kinzler KW, Vogelstein B. Evaluation of the FHIT gene in colorectal cancers. Cancer Res. 1996 Jul 1; 56(13):2936-9. PMID: 8674044

Thiagalingam S, Kinzler KW, Vogelstein B. PAK1, a gene that can regulate p53 activity in yeast. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6062-6. PMID: 7597081; PMCID: PMC41642

Tokino T, Thiagalingam S, el-Deiry WS, Waldman T, Kinzler KW, Vogelstein B. p53 tagged sites from human genomic DNA. Hum Mol Genet. 1994 Sep; 3(9):1537-42. PMID: 7833908

Pietenpol JA, Tokino T, Thiagalingam S, el-Deiry WS, Kinzler KW, Vogelstein B. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):1998-2002. PMID: 8134338; PMCID: PMC43296

Thiagalingam S, Grossman L. The multiple roles for ATP in the Escherichia coli UvrABC endonuclease-catalyzed incision reaction. J Biol Chem. 1993 Aug 25; 268(24):18382-9. PMID: 8349713

Grossman L, Thiagalingam S. Nucleotide excision repair, a tracking mechanism in search of damage. J Biol Chem. 1993 Aug 15; 268(23):16871-4. PMID: 8349576

Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 1993 Apr 29; 362(6423):857-60. PMID: 8479525

Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science. 1992 May 8; 256(5058):827-30. PMID: 1589764

Thiagalingam S, Grossman L. Both ATPase sites of Escherichia coli UvrA have functional roles in nucleotide excision repair. J Biol Chem. 1991 Jun 15; 266(17):11395-403. PMID: 1828249

Oh EY, Claassen L, Thiagalingam S, Mazur S, Grossman L. ATPase activity of the UvrA and UvrAB protein complexes of the Escherichia coli UvrABC endonuclease. Nucleic Acids Res. 1989 Jun 12; 17(11):4145-59. PMID: 2525700; PMCID: PMC317925

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 70 publications over 32 distinct years, with a maximum of 7 publications in 2025

Bar chart showing 70 publications over 32 distinct years, with a maximum of 7 publications in 2025

Year	Publications
1989	1
1991	1
1992	1
1993	3
1994	2
1995	1
1996	3
1997	3
1999	1
2001	3
2002	1
2003	1
2004	1
2005	4
2006	2
2007	1
2008	2
2009	2
2010	1
2011	5
2012	1
2014	1
2015	4
2016	2
2018	1
2019	2
2020	2
2021	1
2022	1
2023	5
2024	4
2025	7

2019-2020 BU-BMC Cancer Center: Carter Award for Diversity and Cancer Equity

2008-2011 Susan G. Komen for the Cure : Investigator Initiated Research Award

2006-2008 NARSAD/Brain & Behavior Research Foundation: NARSAD Independent Investigator Award - 2006/2007 NARSAD Dr. Walter F. Nichols Investigator

2001-2005 Department of Defense BCRP, USAMRMC: Career Development Award

2000-2002 Smith Family Foundation/The Medical Foundation: New Investigator Award (Dolphin Trust Investigator)