Michael Alosco, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Neurology

PhD, Kent State University
MA, Kent State University
BA, Providence College



Dr. Alosco is a licensed clinical neuropsychologist and serves as the co-director of the Boston University Alzheimer’s Disease Research Center Clinical Core and is a lead investigator of the BU CTE Center. He also oversees Neuropsychology for the Memory and Aging Clinic at Boston Medical Center. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus on neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. Dr. Alosco completed his post-doctoral studies in neuropsychology via NIH-funded training Awards (T32, F32) at the Boston University Alzheimer’s Disease Research Center and CTE Center. In 2018, he became an Assistant Professor of Neurology at the Chobanian and Avedisian School of Medicine and he was promoted to Associate Professor in 2019. Dr. Alosco has >150 peer-reviewed publications, is the PI of multiple NIH funded grants, is the recipient of an NIH/NINDS K23 Award, is the Project Lead of an NIH-funded multisite U54 grant, and serves as aco-investigator on numerous federal and non-federal funded grants. He has also written numerous book chapters, and he is the co-Editor of the Oxford Handbook of Adult Cognitive Disorders which was published by Oxford University Press in 2019.

Dr. Alosco has an active and established research program that has a thematic focus on three areas: (1) the relationship between repetitive head impacts (RHI) and traumatic brain injury (TBI) with a later-life cognitive and neuropsychiatric decline, as well as neurodegenerative disease(s); (2) the contribution of cerebrovascular disease to the clinical and neuropathological expression of CTE, AD, and AD-related dementias (ADRD); and (3) in vivo biomarker development for CTE, AD, and ADRD with a focus on tau PET imaging, structural MRI, and blood-based biomarkers.


Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-02

Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
09/15/2021 - 08/31/2024 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS122854-01

Human Tau Imaging
08/01/2020 - 07/31/2023 (Subcontract PI)
The Regents of the University of California, San Francisco Rainwater Char. Fdn


Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls
08/01/2018 - 04/30/2023 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5K23NS102399-05

In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET
01/01/2021 - 12/31/2022 (Subcontract PI)
The Regents of the University of California, San Francisco NIH NINDS
5R21NS120629-02

Cerebral perfusion and metabolism in chronic traumatic encephalopathy
11/01/2017 - 10/31/2020 (PI)
The Brigham and Women's Hospital, Inc.


Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy
05/01/2016 - 04/30/2018 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
5F32NS096803-02



Title


Yr Title Project-Sub Proj Pubs
2022 In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET 5R21NS120629-02
2022 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-04-6600
2022 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-05
2021 Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms 1RF1NS122854-01
2021 In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET 1R21NS120629-01
2021 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-03-6600
2021 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-04 13
2020 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-02-6600
2020 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-03 13
2019 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-02 13
Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 Oct 21; 145(10):3546-3557.View Related Profiles. PMID: 35554506; DOI: 10.1093/brain/awac175;
     
  2. Atherton K, Han X, Chung J, Cherry JD, Baucom Z, Saltiel N, Nair E, Abdolmohammadi B, Uretsky M, Khan MM, Shea C, Durape S, Martin BM, Palmisano JN, Farrell K, Nowinski CJ, Alvarez VE, Dwyer B, Daneshvar DH, Katz DI, Goldstein LE, Cantu RC, Kowall NW, Alosco ML, Huber BR, Tripodis Y, Crary JF, Farrer L, Stern RA, Stein TD, McKee AC, Mez J. Association of APOE Genotypes and Chronic Traumatic Encephalopathy. JAMA Neurol. 2022 Aug 01; 79(8):787-796.View Related Profiles. PMID: 35759276; PMCID: PMC9237800; DOI: 10.1001/jamaneurol.2022.1634;
     
  3. LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Relationship Between Level of American Football Playing and Diagnosis of Chronic Traumatic Encephalopathy in a Selection Bias Analysis. Am J Epidemiol. 2022 Jul 23; 191(8):1429-1443.View Related Profiles. PMID: 35434739; DOI: 10.1093/aje/kwac075;
     
  4. Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Multimodal deep learning for Alzheimer's disease dementia assessment. Nat Commun. 2022 Jun 20; 13(1):3404.View Related Profiles. PMID: 35725739; PMCID: PMC9209452; DOI: 10.1038/s41467-022-31037-5;
     
  5. Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096.View Related Profiles. PMID: 35663558; PMCID: PMC9160996; DOI: 10.3389/fnins.2022.855096;
     
  6. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Jun 14; 98(24):e2454-e2464.View Related Profiles. PMID: 35444054; PMCID: PMC9231841; DOI: 10.1212/WNL.0000000000200304;
     
  7. Phelps A, Alosco ML, Baucom Z, Hartlage K, Palmisano JN, Weuve J, Mez J, Tripodis Y, Stern RA. Association of Playing College American Football With Long-term Health Outcomes and Mortality. JAMA Netw Open. 2022 Apr 01; 5(4):e228775.View Related Profiles. PMID: 35442450; PMCID: PMC9021915; DOI: 10.1001/jamanetworkopen.2022.8775;
     
  8. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles. PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;
     
  9. Daneshvar DH, Alosco ML. In search of cost-effective and non-invasive biomarkers of traumatic brain injury. EBioMedicine. 2022 Feb; 76:103823.View Related Profiles. PMID: 35074628; PMCID: PMC8792432; DOI: 10.1016/j.ebiom.2022.103823;
     
  10. Fang Y, Doyle MF, Alosco ML, Mez J, Satizabal CL, Qiu WQ, Lunetta KL, Murabito JM. Cross-Sectional Association Between Blood Cell Phenotypes, Cognitive Function, and Brain Imaging Measures in the Community-Based Framingham Heart Study. J Alzheimers Dis. 2022; 87(3):1291-1305.View Related Profiles. PMID: 35431244
     
Showing 10 of 169 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 169 publications over 13 distinct years, with a maximum of 25 publications in 2013

YearPublications
20104
20115
201213
201325
201424
201511
201614
201711
201811
201912
202013
202115
202211


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Repeated Head Impact Linked With Emotional, Cognitive Problems Later in Life

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Repetitive Hits to the Head Tied To Depression, Poor Cognition in Later Life

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Repeat Head Impacts May Lead to Depression Later

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Repeated head impacts, brain injury increase risk for depression

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Hype or horror? The risk of CTE brain disease divides football and medical communities

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Ex-NFL Players Six Times More Likely than the General Public to Report Cognitive Problems, Study Finds

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Five New Answers About the Link Between Football, CTE, and Dementia

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Football Head Trauma Linked Again to Long-Term Brain Damage

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Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

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On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

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Dementia-related marker found in former pro athletes with concussion history

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For Patients With Memory Loss, Working Towards Better Diagnosis

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Free Event for Caregivers

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How A Massachusetts Bill Could Affect Local Pop Warner Teams

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California bill would limit tackling during youth practices. Why it has leagues’ support

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Subconcussive Head Impacts Alter Oculomotor Responses

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Can Playing Football Lead Your Child To Develop a Disability?

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Starting tackle football early sets kids up for brain problems

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MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing tackle footall before 12 can lead to long-term consequences

WCVB ABC 5 4/30/2018

2014 Kent State University: David B. Smith Award: Recognition Award for the most outstanding graduate student at Kent State U.
2014 Applied Psychology Center: Publication Award
2013 Applied Psychology Center: Publication Award
2012 American Psychological Association (APA): David Pilon Training Scholarship Award
2012 American Psychological Association (APA): Early Graduate Student Researcher Award
2011-2013 Graduate Student Senate at Kent State University: Domestic Travel Grant Award
2011-2013 Kent State University: Travel Award Applied Psychology Center
2011-2013 Kent State University: Student Travel Award, Department of Psychology
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Neurodegenerative conditions
cerebrovascular disease
head impacts
long-term neurological consequences
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