Michael Alosco, PhD
Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Kent State University
MA, Kent State University




Dr. Alosco completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus in neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. In 2015, Dr. Alosco was awarded a post-doctoral fellowship at the Boston University (BU) Alzheimer’s Disease (AD) Center (ADC) and BU CTE Center through the NIA-funded Alzheimer’s Disease Translational Research Training Program (T32AG036697). In 2016, Dr. Alosco transitioned to a National Research Service Award (NRSA) F32 from the National Institute of Neurological Disorders and Stroke to continue his advanced clinical research training at the BU ADC and BU CTE Center. In 2018, he became an Assistant Professor of Neurology at the Boston University School of Medicine.

Dr. Alosco’s research focuses on risk factors and biomarkers of neurodegenerative conditions, with a focus on AD and CTE. Dr. Alosco is particularly interested in the contribution of cerebrovascular disease to the clinical and neuropathological presentation of AD and CTE. He is additionally involved in research examining the relationship between exposure to repetitive head impacts and long-term neurological consequences. He is mentored at the BU AD and CTE Center by Robert A. Stern, Ph.D., and Ann C. McKee, M.D.

In August 2018, he received a five-year K23 Award from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS). He will use MRI data and biomarkers to examine patterns of white matter alterations in former NFL players compared to healthy individuals as well as those with Alzheimer’s disease dementia. He will do so by leveraging ongoing studies at BUSM, including the NINDS-funded DIAGNOSE CTE Research Project and the National Institute on Aging (NIA) funded BU Alzheimer’s Disease Center (BU ADC). The K23 Award will additionally provide Dr. Alosco with advanced and cutting-edge training in CTE to facilitate his progression as an independent clinical neuroscientist.

2014 Kent State University: David B. Smith Award: Recognition Award for the most outstanding graduate student at Kent State U.
2014 Applied Psychology Center: Publication Award
2013 Applied Psychology Center: Publication Award
2012 American Psychological Association (APA): David Pilon Training Scholarship Award
2012 American Psychological Association (APA): Early Graduate Student Researcher Award
2011-2013 Graduate Student Senate at Kent State University: Domestic Travel Grant Award
2011-2013 Kent State University: Travel Award Applied Psychology Center
2011-2013 Kent State University: Student Travel Award, Department of Psychology


Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls
08/01/2018 - 04/30/2023 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5K23NS102399-04

In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET
01/01/2021 - 12/31/2022 (Subcontract PI)
The Regents of the University of California, San Francisco NIH NINDS
1R21NS120629-01

Human Tau Imaging
08/01/2020 - 07/31/2021 (Subcontract PI)
The Regents of the University of California, San Francisco Rainwater Char. Fdn


Cerebral perfusion and metabolism in chronic traumatic encephalopathy
11/01/2017 - 10/31/2020 (PI)
The Brigham and Women's Hospital, Inc.


Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy
05/01/2016 - 04/30/2018 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
5F32NS096803-02



Title


Yr Title Project-Sub Proj Pubs
2021 In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET 1R21NS120629-01
2021 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-04 13
2020 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-02-6600
2020 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-03 13
2019 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-02 13
2019 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 1U54NS115266-01-6600
2018 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 1K23NS102399-01A1 13
2017 Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy 3F32NS096803-01S1 22
2017 Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy 5F32NS096803-02 22
2016 Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy 1F32NS096803-01 22

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Tao Q, Alvin Ang TF, Akhter-Khan SC, Itchapurapu IS, Killiany R, Zhang X, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML, Qiu WQ. Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous Apolipoprotein E ?4 Carriers. Neurology. 2021 Jul 15.View Related Profiles. PMID: 34266923
     
  2. Kochsiek J, O'Donnell LJ, Zhang F, Bonke EM, Sollmann N, Tripodis Y, Wiegand TLT, Kaufmann D, Umminger L, Di Biase MA, Kaufmann E, Schultz V, Alosco ML, Martin BM, Lin AP, Coleman MJ, Rathi Y, Pasternak O, Bouix S, Stern RA, Shenton ME, Koerte IK. Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players. J Magn Reson Imaging. 2021 Jun 16.View Related Profiles. PMID: 34137112
     
  3. Kaufmann D, Sollmann N, Kaufmann E, Veggeberg R, Tripodis Y, Wrobel PP, Kochsiek J, Martin BM, Lin AP, Coleman MJ, Alosco ML, Pasternak O, Bouix S, Stern RA, Shenton ME, Koerte IK. Age at First Exposure to Tackle Football is Associated with Cortical Thickness in Former Professional American Football Players. Cereb Cortex. 2021 Jun 10; 31(7):3426-3434.View Related Profiles. PMID: 33676369; PMCID: PMC8196248; DOI: 10.1093/cercor/bhab021;
     
  4. Alosco ML, Culhane J, Mez J. Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic. Neurotherapeutics. 2021 Apr 13.View Related Profiles. PMID: 33847906
     
  5. Mez J, Alosco ML, Daneshvar DH, Saltiel N, Baucom Z, Abdolmohammadi B, Uretsky M, Nicks R, Martin BM, Palmisano JN, Nowinski CJ, Montenigro P, Solomon TM, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Goldstein LE, Katz DI, Cantu RC, Kowall NW, Tripodis Y, Huber BR, Stein TD, Stern RA, McKee AC. Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology. Alzheimers Dement. 2021 Apr 07.View Related Profiles. PMID: 33826224
     
  6. Akhter-Khan SC, Tao Q, Ang TFA, Itchapurapu IS, Alosco ML, Mez J, Piers RJ, Steffens DC, Au R, Qiu WQ. Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study. Alzheimers Dement. 2021 Mar 24.View Related Profiles. PMID: 33760348
     
  7. Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O'Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley ÉM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome. Neurology. 2021 05 04; 96(18):848-863.View Related Profiles. PMID: 33722990; PMCID: PMC8166432; DOI: 10.1212/WNL.0000000000011850;
     
  8. Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Dams-O'Connor K, Gordon WA, Tripodis Y, Alvarez VE, Mez J, Alosco ML, McKee AC. The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2021 Feb 22; 80(3):210-219.View Related Profiles. PMID: 33611507; PMCID: PMC7899277; DOI: 10.1093/jnen/nlab001;
     
  9. Cherry JD, Meng G, Daley S, Xia W, Svirsky S, Alvarez VE, Nicks R, Pothast M, Kelley H, Huber B, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy. J Neuroinflammation. 2020 Dec 05; 17(1):370.View Related Profiles. PMID: 33278887; PMCID: PMC7718711; DOI: 10.1186/s12974-020-02036-4;
     
  10. Alosco ML, Tripodis Y, Rowland B, Chua AS, Liao H, Martin B, Jarnagin J, Chaisson CE, Pasternak O, Karmacharya S, Koerte IK, Cantu RC, Kowall NW, McKee AC, Shenton ME, Greenwald R, McClean M, Stern RA, Lin A. A magnetic resonance spectroscopy investigation in symptomatic former NFL players. Brain Imaging Behav. 2020 Oct; 14(5):1419-1429.View Related Profiles. PMID: 30848432; PMCID: PMC6994233; DOI: 10.1007/s11682-019-00060-4;
     
Showing 10 of 151 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 151 publications over 12 distinct years, with a maximum of 25 publications in 2013

YearPublications
20104
20115
201213
201325
201424
201511
201614
201711
201811
201912
202013
20218


Researchers receive $460,000 NIH grant for brain imaging study

News Medical 1/19/2021

Repeated Head Impact Linked With Emotional, Cognitive Problems Later in Life

Psych Congress Network 7/13/2020

Repetitive Hits to the Head Tied To Depression, Poor Cognition in Later Life

Medscape 7/9/2020

Repeat Head Impacts May Lead to Depression Later

Futurity 6/30/2020

Repeated head impacts, brain injury increase risk for depression

UPI 6/26/2020

Hype or horror? The risk of CTE brain disease divides football and medical communities

Fox News 3/4/2020

Ex-NFL Players Six Times More Likely than the General Public to Report Cognitive Problems, Study Finds

The Boston Globe 8/30/2019

Rochester Woman Advocates for Alzheimer's Caregivers

The Union Leader 8/22/2019

Deeper Dive Into CTE, Dementia in Football Reveals New Players

Medscape 8/12/2019

What Years of Playing Football Does to Brain’s White Matter

Futurity 8/12/2019

Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia

Alzforum 8/9/2019

Five New Answers About the Link Between Football, CTE, and Dementia

BU Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

Health Day 8/5/2019

Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

U.S. News & World Report 8/5/2019

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Genetic Literacy Project 6/13/2019

Dementia-related marker found in former pro athletes with concussion history

Reuters 5/8/2019

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

Free Event for Caregivers

Carriage Towne News 4/24/2019

How A Massachusetts Bill Could Affect Local Pop Warner Teams

Newport RI 3/5/2019

California bill would limit tackling during youth practices. Why it has leagues’ support

The Sacramento Bee 1/15/2019

Subconcussive Head Impacts Alter Oculomotor Responses

Reuters Health 12/26/2018

Can Playing Football Lead Your Child To Develop a Disability?

Ruderman Family Foundation 11/5/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing tackle footall before 12 can lead to long-term consequences

WCVB ABC 5 4/30/2018
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Neurodegenerative conditions
cerebrovascular disease
head impacts
long-term neurological consequences
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