Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
08/15/2024 - 07/31/2029 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS139383-02

The Role of Genetic Risk Factors and Immune Response on NVU Function in Post-TBI Cognitive Impairment
11/01/2024 - 10/31/2028 (Subcontract PI)
Scintillon Research Institute DOD Army Med Resrch


ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)
09/01/2024 - 08/31/2028 (Subcontract PI)
University of Washington NIH NIA
5U01AG082350-02

Neuroimaging Research for Veterans (NeRVe) Center - Service Contract
08/01/2023 - 07/31/2028 (Multi-PI)
PI: Michael Alosco, PhD
VA Boston Healthcare System


Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research
09/30/2023 - 06/30/2028 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute on Aging
5R01AG077588-03

Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
06/01/2025 - 05/31/2028 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
4R01NS132290-02

Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
09/01/2024 - 08/31/2026 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS122854-03

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-04

Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
02/01/2021 - 01/31/2026 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS119651-05

18F-PI-2620 Tau PET as a Biomarker for Chronic Traumatic Encephalopathy
03/15/2023 - 12/04/2025 (PI)
Life Molecular Imaging Ltd


Showing 10 of 21 results. Show All Results

1. Subramanian ML, Sampani K, Ness S, Tuz-Zahra F, Alluri S, Chen X, Siegel NH, Aytan N, Xia W, Tripodis Y, Alosco ML, Stein TD. Biomarkers for Alzheimer's disease are upregulated in patients with diabetic retinopathy. J Alzheimers Dis. 2025 Nov; 108(2):586-596.View Related Profiles.

   Subramanian, Manju
   Alosco, Michael
   Siegel, Nicole
   Aytan, Nurgul
   Stein, Thor
   Chen, Xuejing
   Tripodis, Yorghos
   

   PMID: 40982223; DOI: 10.1177/13872877251378759;
2. Jung LB, Mirmajlesi AS, Stearns J, Breedlove K, John O, Kim N, Wickham A, Su Y, Protas H, Baucom ZH, Tuz-Zahra F, Tripodis Y, Daneshvar DH, Wiegand TLT, Billah T, Pasternak O, Heller C, Im BS, Datta S, Coleman MJ, Adler CH, Bernick C, Balcer LJ, Alosco ML, Lin AP, Cummings JL, Reiman EM, Stern RA, Shenton ME, Bouix S, Koerte IK, Arciniega H. Sulcal morphology in former American football players. Brain Commun. 2025; 7(5):fcaf345.View Related Profiles.

   Alosco, Michael
   Tripodis, Yorghos
   

   PMID: 41048544; PMCID: PMC12492488; DOI: 10.1093/braincomms/fcaf345;
3. Alosco ML, Morrison M, Au R, Steinberg EG, Mwicigi J, Ly M, Altaras C, Lenio S, Abdennadher M, O'Connor MK, Tripodis Y, Palmisano J, Dixon D, Martin B, Schneider G, Groh JR, Ellison A, Sheppard D, Farris CW, Nowinski C, Cantu RC, Turk KW, Farrer L, Jun G, Goldstein LE, Qiu WQ, Stein TD, Budson AE, McKee AC, Mez J. Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post-traumatic Alzheimer's disease and related dementias. Alzheimers Dement. 2025 Sep; 21(9):e70654.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Altaras, Caroline
   Farris, Chad
   Nowinski, Christopher
   Steinberg, Eric
   Jun, Gyungah
   Groh, Jenna
   Mez, Jesse
   Palmisano, Joseph
   Turk, Katherine
   Goldstein, Lee
   Farrer, Lindsay
   O'Connor, Maureen
   Alosco, Michael
   Ly, Monica
   Abdennadher, Myriam
   Au, Rhoda
   Lenio, Steven
   Stein, Thor
   Qiu, Wendy
   Tripodis, Yorghos
   

   PMID: 40923312; PMCID: PMC12418077; DOI: 10.1002/alz.70654;
4. Gao A, Tuz-Zahra F, Vig V, Zeng R, Tripodis Y, Stein TD, Alosco ML, Ness S, Chen X, Siegel N, Subramanian ML. The Association between Retinal Vascular Occlusions and Dementia: A UK Biobank Retrospective Longitudinal Study. Ophthalmol Retina. 2025 Aug 16.View Related Profiles.

   Subramanian, Manju
   Alosco, Michael
   Siegel, Nicole
   Tripodis, Yorghos
   

   PMID: 40825393; DOI: 10.1016/j.oret.2025.08.010;
5. Ness S, Sampani K, Tuz-Zahra F, Aytan N, Alluri S, Fiorello MG, Chen X, Siegel NH, Alosco ML, Xia W, Tripodis Y, Stein TD, Subramanian ML. Glial fibrillary acidic protein in plasma and intraocular fluids and the correlation with cognitive function in patients with vitreoretinal disease. Sci Rep. 2025 Aug 06; 15(1):28720.View Related Profiles.

   Subramanian, Manju
   Alosco, Michael
   Siegel, Nicole
   Aytan, Nurgul
   Ness, Steven
   Stein, Thor
   Chen, Xuejing
   Tripodis, Yorghos
   

   PMID: 40770000; PMCID: PMC12328637; DOI: 10.1038/s41598-025-13260-4;
6. Fang Y, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Doyle MF, Murabito JM, Lunetta KL. Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study. Front Aging Neurosci. 2025; 17:1471154.View Related Profiles.

   Satizabal, Claudia
   Mez, Jesse
   Murabito, Joanne
   Lunetta, Kathryn
   Alosco, Michael
   Qiu, Wendy
   

   PMID: 40636900; PMCID: PMC12238755; DOI: 10.3389/fnagi.2025.1471154;
7. Manley GT, Dams-O'Connor K, Alosco ML, Awwad HO, Bazarian JJ, Bragge P, Corrigan JD, Doperalski A, Ferguson AR, Mac Donald CL, Menon DK, McNett MM, van der Naalt J, Nelson LD, Pisica D, Silverberg ND, Umoh N, Wilson L, Yuh EL, Zetterberg H, Maas AIR, McCrea MA. A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative. Lancet Neurol. 2025 Jun; 24(6):512-523. PMID: 40409315
8. Gaudet CE, Jackson CE, Asken B, Ly M, Altaras C, Lenio S, Mez J, Alosco ML. Prevalence of low scores in the Uniform Data Set version 3.0: Comparison of older adults with and without a self-reported history of traumatic brain injury. J Int Neuropsychol Soc. 2025 May 21; 1-10.View Related Profiles.

   Altaras, Caroline
   Gaudet, Charles
   Mez, Jesse
   Alosco, Michael
   Ly, Monica
   Lenio, Steven
   

   PMID: 40395093
9. Corrigan JD, Alosco ML, van der Naalt J, Adams RS, Asken BM, Hinds S, Lequerica AH, Newcombe V, Tenovuo O, Valera E, Yurgelun-Todd D, Doperalski A, Awwad HO, Dams-O'Connor K, Maas AIR, McCrea MA, Umoh N, Manley GT. Retrospective Identification and Characterization of Traumatic Brain Injury-Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Retrospective Classification Working Group. J Neurotrauma. 2025 Jul; 42(13-14):1086-1095.View Related Profiles.

   Alosco, Michael
   Adams, Rachel
   

   PMID: 40393476; PMCID: PMC12409120; DOI: 10.1089/neu.2024.0590;
10. Cao Y, Salvati LR, Chen J, Ragab A, Mez J, Satizabal CL, Alosco ML, Fang Y, Qiu WQ, Lunetta KL, Murabito JM, Doyle MF. The Association of Circulating Immune Cells With Cognitive Function, Brain Imaging, and Incident All-cause and Alzheimer's Dementia: The Framingham Offspring Study. J Gerontol A Biol Sci Med Sci. 2025 May 05; 80(6).View Related Profiles.

    Ragab, Ahmed
    Satizabal, Claudia
    Mez, Jesse
    Murabito, Joanne
    Lunetta, Kathryn
    Alosco, Michael
    Qiu, Wendy
    Fang, Yuan
    

    PMID: 40168089; PMCID: PMC12128850; DOI: 10.1093/gerona/glaf067;

Showing 10 of 250 results. Show More

Is the NFL Safer Than High School Football?

Behind the race to detect — and treat — brain disease CTE before it kills

---

'We're here to help' Boston University's CTE Center doctor says after Manhattan shooting

Dolphins quarterback set to return to practice after 3rd NFL concussion

“It Will Make CTE a Treatable Disease”: The Race for a Diagnosis in Life

Research on CTE and Concussions Changed the NFL. Experts Say That’s Not Enough

10 Things BU CTE Center Research Has Taught Us About the Brain Dangers of Contact Sports and Military Service

What Is CTE?

'Physician Spending Is Not the Problem in Healthcare': What We Heard This Week (

One in Three Former NFL Players Believe They Have CTE

As denials pile up, NFL settlement ignores ‘critical’ tests

BU researchers publish ‘crucial’ study that could help diagnose CTE before death

Researchers get closer to diagnosing CTE in living patients

New Findings in Football Players May Aid the Future Diagnosis and Study of Chronic Traumatic Encephalopathy (CTE)

What MRI-Derived Data and Other Factors Reveal About White Matter Hyperintensity in Former Football Players

Former Pro Football Players Show Troubling Brain Changes

Study of former football players shows brain changes

Former Pro Football Players Show Troubling Brain Changes

AAN study reveals Brain Lesions in Former Football Players Linked to Vascular, Brain Changes

Study of former football players shows brain changes

Football linked to more brain damage beyond white matter marks

Changes in the Diagnostic Process of Alzheimer Disease: A New Era of Blood-Based Approaches

Can Playing Football Increase Parkinson’s Risk?

Heads up: Concussions are common in soccer — especially for girls — but rules are changing to keep young athletes safe

Playing football can increase risk of Parkinson’s. Would you let your child play?

Playing Football Linked to Higher Parkinson's Risk

Can playing football increase Parkinson’s risk?

Playing Football Linked to Higher Parkinson's Risk

Playing football may increase risk of Parkinson’s disease, study suggests

Playing tackle football may raise the risk for Parkinson’s disease: Boston University CTE Center

Playing football may increase risk for Parkinson's disease, study says

Playing Football Might Raise Parkinson's Risk

Playing Football Linked to Increased Parkinson's Ris

Football players at increased risk for Parkinson's disease, study finds

Playing football may increase risk of Parkinson’s disease, study suggests

Playing Football Might Raise Parkinson's Risk

Playing Football May Increase the Risk for Developing Parkinson’s Disease

Playing tackle football at an early age increases risk for brain decline later

Long football careers linked to impulsive behavior, less white matter in the brain: Boston University CTE study

New BU Study Finds Tackle Football at Young Age Raises Risk for Brain Decline Later

Former Bronco plans to donate brain for concussion research: "If they want my brain they can have it"

Alzheimer's: Could beer hop compounds help reduce toxic clumps?

CTE: The Mysterious Brain Disorder That’s Taken Over the NFL

Boston University Researchers Study Contact Sports' Impact On Brains

Kraken broadcaster JT Brown said he plans to donate his brain to CTE research

White Matter Hyperintensities Linked to Repetitive Head Trauma

Could Structural MRI Findings Help Detect CTE During Life?

MRI Might Spot Concussion-Linked CTE in Living Patients

MRI Might Spot Concussion-Linked CTE in Living Patient

MRI Key to Diagnosing CTE in Living Patients?

More Years Playing Football, More Brain Lesions on MRI: Study

More Years Playing Football, More Brain Lesions on MRI: Study

Men who were in boxing clubs as youngsters may be THREE times as likely to develop Alzheimer's disease, study warns

Post-TBI Cognitive Changes 'Strikingly' Similar to Early Parkinson's

Researchers receive $460,000 NIH grant for brain imaging study

Repeated Head Impact Linked With Emotional, Cognitive Problems Later in Life

Repetitive Hits to the Head Tied To Depression, Poor Cognition in Later Life

Repeat Head Impacts May Lead to Depression Later

Repeated head impacts, brain injury increase risk for depression

Hype or horror? The risk of CTE brain disease divides football and medical communities

Ex-NFL Players Six Times More Likely than the General Public to Report Cognitive Problems, Study Finds

Rochester Woman Advocates for Alzheimer's Caregivers

Deeper Dive Into CTE, Dementia in Football Reveals New Players

What Years of Playing Football Does to Brain’s White Matter

Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia

Five New Answers About the Link Between Football, CTE, and Dementia

Football Head Trauma Linked Again to Long-Term Brain Damage

Dementia Tied to White Matter Rarefaction in Football Players With CTE

Football Head Trauma Linked Again to Long-Term Brain Damage

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Dementia-related marker found in former pro athletes with concussion history

For Patients With Memory Loss, Working Towards Better Diagnosis

Free Event for Caregivers

How A Massachusetts Bill Could Affect Local Pop Warner Teams

California bill would limit tackling during youth practices. Why it has leagues’ support

Subconcussive Head Impacts Alter Oculomotor Responses

Can Playing Football Lead Your Child To Develop a Disability?

Starting tackle football early sets kids up for brain problems

MED Researchers: Youth Football Linked to Earlier Brain Problems

Playing tackle footall before 12 can lead to long-term consequences