Michael Alosco, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, Kent State University
MA, Kent State University
BA, Providence College



Dr. Alosco is a licensed clinical neuropsychologist and serves as the co-director of the Boston University Alzheimer’s Disease Research Center Clinical Core and is a lead investigator of the BU CTE Center. He also oversees Neuropsychology for the Memory and Aging Clinic at Boston Medical Center. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus on neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. Dr. Alosco completed his post-doctoral studies in neuropsychology via NIH-funded training Awards (T32, F32) at the Boston University Alzheimer’s Disease Research Center and CTE Center. In 2018, he became an Assistant Professor of Neurology at the Chobanian and Avedisian School of Medicine and he was promoted to Associate Professor in 2019. Dr. Alosco has >150 peer-reviewed publications, is the PI of multiple NIH funded grants, is the recipient of an NIH/NINDS K23 Award, is the Project Lead of an NIH-funded multisite U54 grant, and serves as aco-investigator on numerous federal and non-federal funded grants. He has also written numerous book chapters, and he is the co-Editor of the Oxford Handbook of Adult Cognitive Disorders which was published by Oxford University Press in 2019.

Dr. Alosco has an active and established research program that has a thematic focus on three areas: (1) the relationship between repetitive head impacts (RHI) and traumatic brain injury (TBI) with a later-life cognitive and neuropsychiatric decline, as well as neurodegenerative disease(s); (2) the contribution of cerebrovascular disease to the clinical and neuropathological expression of CTE, AD, and AD-related dementias (ADRD); and (3) in vivo biomarker development for CTE, AD, and ADRD with a focus on tau PET imaging, structural MRI, and blood-based biomarkers.


Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
08/15/2024 - 07/31/2029 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R01NS139383-01

Neuroimaging Research for Veterans (NeRVe) Center - Service Contract
08/01/2023 - 07/31/2028 (Multi-PI)
PI: Michael Alosco, PhD
VA Boston Healthcare System


Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research
09/30/2023 - 06/30/2028 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute on Aging
5R01AG077588-02

Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
09/01/2024 - 08/31/2026 (PI)
NIH/National Institute of Neurological Disorders & Stroke
4R01NS122854-02

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-04

Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
02/01/2021 - 01/31/2026 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS119651-04

18F-PI-2620 Tau PET as a Biomarker for Chronic Traumatic Encephalopathy
03/15/2023 - 12/04/2025 (PI)
Life Molecular Imaging Ltd


Alzheimer's Disease Neuroimaging Initiative (ADNI4)
08/01/2024 - 07/31/2025 (Subcontract PI)
Fordham University NIH NIA
5U19AG024904-17

Alzheimer's Disease Neuroimaging Initiative 4 (ADNI 4)
09/15/2022 - 07/31/2025 (Subcontract PI)
University of Southern California NIH NIA
5U19AG024904-17

Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
06/01/2023 - 05/31/2025 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS132290-01

Showing 10 of 18 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2025 Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS) 5R01NS119651-05
2024 Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II 1R01NS139383-01
2024 Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research 5R01AG077588-02
2024 Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms 4R01NS122854-02
2024 Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS) 5R01NS119651-04
2023 Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research 1R01AG077588-01A1
2023 Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias 1RF1NS132290-01
2023 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-05-6542
2022 In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET 5R21NS120629-02
2022 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-04-6600
Showing 10 of 23 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ly MT, Altaras C, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Peskind ER, Banks SJ, Barr WB, Wethe JV, Lenio S, Bondi MW, Delano-Wood LM, Cantu RC, Coleman MJ, Dodick DW, Mez J, Daneshvar DH, Palmisano JN, Martin B, Lin AP, Koerte IK, Bouix S, Cummings JL, Reiman EM, Shenton ME, Stern RA, Alosco ML. Single- versus two-test criteria for cognitive impairment: associations with CSF and imaging markers in former American football players. Clin Neuropsychol. 2025 Jan 20; 1-25.View Related Profiles. PMID: 39834028
     
  2. Asken BM, Brett BL, Barr WB, Banks S, Wethe JV, Dams-O'Connor K, Stern RA, Alosco ML. Chronic traumatic encephalopathy: State-of-the-science update and narrative review. Clin Neuropsychol. 2025 Jan 20; 1-25.View Related Profiles. PMID: 39834035
     
  3. Richardson TE, Orr ME, Orr TC, Rohde SK, Ehrenberg AJ, Thorn EL, Christie TD, Flores-Almazan V, Afzal R, De Sanctis C, Maldonado-Díaz C, Hiya S, Canbeldek L, Kulumani Mahadevan LS, Slocum C, Samanamud J, Clare K, Scibetta N, Yokoda RT, Koenigsberg D, Marx GA, Kauffman J, Goldstein A, Selmanovic E, Drummond E, Wisniewski T, White CL, Goate AM, Crary JF, Farrell K, Alosco ML, Mez J, McKee AC, Stein TD, Bieniek KF, Kautz TF, Daoud EV, Walker JM. Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age-related tauopathy hippocampi. Alzheimers Dement. 2024 Dec 31.View Related Profiles. PMID: 39737785
     
  4. Nicks R, Shah A, Stathas SA, Kirsch D, Horowitz SM, Saltiel N, Calderazzo SM, Butler MLMD, Cormier KA, Aytan N, Tu-Zahra F, Mathias R, Faheem F, Marcus S, Spurlock E, Fishbein L, Esnault CD, Boden A, Rosen G, Xia W, Daley S, Meng G, Martin BR, Daneshvar DH, Nowinski CJ, Alosco ML, Mez J, Tripodis Y, Huber BR, Alvarez VE, Cherry JD, McKee AC, Stein TD. Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts. Acta Neuropathol. 2024 Dec 06; 148(1):79.View Related Profiles. PMID: 39643767; PMCID: PMC11624223; DOI: 10.1007/s00401-024-02833-8;
     
  5. Abdolmohammadi B, Tuz-Zahra F, Uretsky M, Nicks R, Mosaheb S, Labonte J, Yhang E, Durape S, Martin B, Palmisano J, Nowinski C, Cherry JD, Alvarez VE, Huber BR, Dams-O'Connor K, Crary J, Dwyer B, Daneshvar DH, Goldstein LE, Au R, Katz DI, Kowall NW, Cantu RC, Stern RA, Alosco ML, Stein TD, Tripodis Y, McKee AC, Mez J. Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy. JAMA Netw Open. 2024 Dec 02; 7(12):e2449106.View Related Profiles. PMID: 39630446; PMCID: PMC11618473; DOI: 10.1001/jamanetworkopen.2024.49106;
     
  6. Uretsky M, Nair E, Burton R, Cronin SW, Rousseau D, Tuz-Zahra F, Durape S, Abdolmohammadi B, Baucom Z, Saltiel N, Shah A, Martin B, Palmisano J, Cherry JD, Daneshvar D, Dwyer B, Dams-O'Connor K, Crary J, Goldstein L, Huber B, Katz D, Kowall N, Cantu RC, Alvarez VE, Stern RA, Stein TD, Tripodis Y, McKee AC, Alosco ML, Mez J. Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure. Neurology. 2024 Dec 24; 103(12):e210056.View Related Profiles. PMID: 39602665; PMCID: PMC11604107; DOI: 10.1212/WNL.0000000000210056;
     
  7. Prasad M, Goodman D, Gutta S, Sheikh Z, Cabral HJ, Shunyakova J, Sanjiv N, Curley C, Yarala RR, Tsai L, Siegel NH, Chen X, Poulaki V, Alosco ML, Stein TD, Ness S, Subramanian ML. Associations Between Retinal Vascular Occlusions and Dementia. Healthcare (Basel). 2024 Nov 26; 12(23).View Related Profiles. PMID: 39684995; PMCID: PMC11641452; DOI: 10.3390/healthcare12232371;
     
  8. Safransky M, Groh JR, Blennow K, Zetterberg H, Tripodis Y, Martin B, Weller J, Asken BM, Rabinovici GD, Qiu WWQ, McKee AC, Stein TD, Mez J, Henson RL, Long J, Morris JC, Perrin RJ, Schindler SE, Alosco ML. Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease. Neurology. 2024 Dec 10; 103(11):e209866.View Related Profiles. PMID: 39496102; PMCID: PMC11540457; DOI: 10.1212/WNL.0000000000209866;
     
  9. Rosen GA, Kirsch D, Nicks R, Kelley H, Mathias R, Cormier KA, Kubilus CA, Dec B, Stein TD, Alvarez VE, Alosco ML, McKee AC, Huber BR. SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue. Front Neurosci. 2024; 18:1474617.View Related Profiles. PMID: 39445075; PMCID: PMC11496292; DOI: 10.3389/fnins.2024.1474617;
     
  10. Arciniega H, Baucom ZH, Tuz-Zahra F, Tripodis Y, John O, Carrington H, Kim N, Knyazhanskaya EE, Jung LB, Breedlove K, Wiegand TLT, Daneshvar DH, Rushmore RJ, Billah T, Pasternak O, Coleman MJ, Adler CH, Bernick C, Balcer LJ, Alosco ML, Koerte IK, Lin AP, Cummings JL, Reiman EM, Stern RA, Shenton ME, Bouix S. Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project. Brain. 2024 Oct 03; 147(10):3596-3610.View Related Profiles. PMID: 38533783; PMCID: PMC11449133; DOI: 10.1093/brain/awae098;
     
Showing 10 of 230 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 230 publications over 16 distinct years, with a maximum of 29 publications in 2024

YearPublications
20104
20115
201213
201325
201424
201511
201614
201711
201811
201912
202013
202115
202216
202325
202429
20252


Dolphins quarterback set to return to practice after 3rd NFL concussion

Good Morning America 10/22/2024

“It Will Make CTE a Treatable Disease”: The Race for a Diagnosis in Life

The Brink 10/11/2024

Research on CTE and Concussions Changed the NFL. Experts Say That’s Not Enough

The Brink 10/11/2024

10 Things BU CTE Center Research Has Taught Us About the Brain Dangers of Contact Sports and Military Service

The Brink 10/11/2024

What Is CTE?

The Brink 10/11/2024

'Physician Spending Is Not the Problem in Healthcare': What We Heard This Week (

Medpage Today 10/6/2024

One in Three Former NFL Players Believe They Have CTE

Medpage Today 9/23/2024

As denials pile up, NFL settlement ignores ‘critical’ tests

The Washington Post 8/20/2024

BU researchers publish ‘crucial’ study that could help diagnose CTE before death

Boston.com 2/6/2024

Researchers get closer to diagnosing CTE in living patients

Futurity 2/6/2024

New Findings in Football Players May Aid the Future Diagnosis and Study of Chronic Traumatic Encephalopathy (CTE)

NIH Director's Blog 1/18/2024

What MRI-Derived Data and Other Factors Reveal About White Matter Hyperintensity in Former Football Players

Diagnostic Imaging 12/23/2023

Former Pro Football Players Show Troubling Brain Changes

Health Day 12/21/2023

Study of former football players shows brain changes

UPI 12/21/2023

Former Pro Football Players Show Troubling Brain Changes

US News & World Report 12/21/2023

AAN study reveals Brain Lesions in Former Football Players Linked to Vascular, Brain Changes

Business This Week 12/21/2023

Study of former football players shows brain changes

UPI 12/21/2023

Football linked to more brain damage beyond white matter marks

News Medical 12/20/2023

Changes in the Diagnostic Process of Alzheimer Disease: A New Era of Blood-Based Approaches

HCP Live 12/8/2023

Can Playing Football Increase Parkinson’s Risk?

The Good Men Project 9/17/2023

Heads up: Concussions are common in soccer — especially for girls — but rules are changing to keep young athletes safe

The Boston Globe 9/3/2023

Playing football can increase risk of Parkinson’s. Would you let your child play?

Boston.com 8/17/2023

Playing Football Linked to Higher Parkinson's Risk

Medscape 8/15/2023

Can playing football increase Parkinson’s risk?

Futurity 8/15/2023

Playing Football Linked to Higher Parkinson's Risk

Medscape 8/15/2023

Playing football may increase risk of Parkinson’s disease, study suggests

The Philadelphia Tribune 8/14/2023

Playing tackle football may raise the risk for Parkinson’s disease: Boston University CTE Center

Boston Herald 8/12/2023

Playing football may increase risk for Parkinson's disease, study says

UPI 8/11/2023

Playing Football Might Raise Parkinson's Risk

Health Day 8/11/2023

Playing Football Linked to Increased Parkinson's Ris

News Max 8/11/2023

Football players at increased risk for Parkinson's disease, study finds

News Medical 8/11/2023

Playing football may increase risk of Parkinson’s disease, study suggests

CNN 8/11/2023

Playing Football Might Raise Parkinson's Risk

US News & World Report 8/11/2023

Playing Football May Increase the Risk for Developing Parkinson’s Disease

BU Today 8/11/2023

Playing tackle football at an early age increases risk for brain decline later

News Medical 3/20/2023

Long football careers linked to impulsive behavior, less white matter in the brain: Boston University CTE study

Boston Herald 3/7/2023

New BU Study Finds Tackle Football at Young Age Raises Risk for Brain Decline Later

The Brink 3/6/2023

Former Bronco plans to donate brain for concussion research: "If they want my brain they can have it"

CBS News 12/8/2022

Alzheimer's: Could beer hop compounds help reduce toxic clumps?

Medical News Today 11/11/2022

CTE: The Mysterious Brain Disorder That’s Taken Over the NFL

Radio Health Journal 5/1/2022

Boston University Researchers Study Contact Sports' Impact On Brains

WBZ News Radio 3/8/2022

Kraken broadcaster JT Brown said he plans to donate his brain to CTE research

KOMO News 2/22/2022

White Matter Hyperintensities Linked to Repetitive Head Trauma

Neurology Today 12/16/2021

Could Structural MRI Findings Help Detect CTE During Life?

Diagnostic Imaging 12/16/2021

MRI Might Spot Concussion-Linked CTE in Living Patients

US News & World Report 12/8/2021

MRI Might Spot Concussion-Linked CTE in Living Patient

Health Day 12/8/2021

MRI Key to Diagnosing CTE in Living Patients?

Medscape 12/7/2021

More Years Playing Football, More Brain Lesions on MRI: Study

Health Day 11/29/2021

More Years Playing Football, More Brain Lesions on MRI: Study

US News & World Report 11/29/2021

Men who were in boxing clubs as youngsters may be THREE times as likely to develop Alzheimer's disease, study warns

Daily Mail 11/28/2021

Post-TBI Cognitive Changes 'Strikingly' Similar to Early Parkinson's

Medscape 11/22/2021

Researchers receive $460,000 NIH grant for brain imaging study

News Medical 1/19/2021

Repeated Head Impact Linked With Emotional, Cognitive Problems Later in Life

Psych Congress Network 7/13/2020

Repetitive Hits to the Head Tied To Depression, Poor Cognition in Later Life

Medscape 7/9/2020

Repeat Head Impacts May Lead to Depression Later

Futurity 6/30/2020

Repeated head impacts, brain injury increase risk for depression

UPI 6/26/2020

Hype or horror? The risk of CTE brain disease divides football and medical communities

Fox News 3/4/2020

Ex-NFL Players Six Times More Likely than the General Public to Report Cognitive Problems, Study Finds

The Boston Globe 8/30/2019

Rochester Woman Advocates for Alzheimer's Caregivers

The Union Leader 8/22/2019

Deeper Dive Into CTE, Dementia in Football Reveals New Players

Medscape 8/12/2019

What Years of Playing Football Does to Brain’s White Matter

Futurity 8/12/2019

Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia

Alzforum 8/9/2019

Five New Answers About the Link Between Football, CTE, and Dementia

BU Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

Health Day 8/5/2019

Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

U.S. News & World Report 8/5/2019

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Genetic Literacy Project 6/13/2019

Dementia-related marker found in former pro athletes with concussion history

Reuters 5/8/2019

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

Free Event for Caregivers

Carriage Towne News 4/24/2019

How A Massachusetts Bill Could Affect Local Pop Warner Teams

Newport RI 3/5/2019

California bill would limit tackling during youth practices. Why it has leagues’ support

The Sacramento Bee 1/15/2019

Subconcussive Head Impacts Alter Oculomotor Responses

Reuters Health 12/26/2018

Can Playing Football Lead Your Child To Develop a Disability?

Ruderman Family Foundation 11/5/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing tackle footall before 12 can lead to long-term consequences

WCVB ABC 5 4/30/2018

2014 Kent State University: David B. Smith Award: Recognition Award for the most outstanding graduate student at Kent State U.
2014 Applied Psychology Center: Publication Award
2013 Applied Psychology Center: Publication Award
2012 American Psychological Association (APA): David Pilon Training Scholarship Award
2012 American Psychological Association (APA): Early Graduate Student Researcher Award
2011-2013 Graduate Student Senate at Kent State University: Domestic Travel Grant Award
2011-2013 Kent State University: Travel Award Applied Psychology Center
2011-2013 Kent State University: Student Travel Award, Department of Psychology
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Neurodegenerative conditions
cerebrovascular disease
head impacts
long-term neurological consequences
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