Michael Alosco, PhD
Associate Professor
Boston University School of Medicine
Dept of Neurology

PhD, Kent State University
MA, Kent State University




Dr. Alosco is a licensed clinical neuropsychologist and serves as the co-director of the Boston University Alzheimer’s Disease Research Center Clinical Core and is a lead investigator of the BU CTE Center. He also oversees Neuropsychology for the Memory and Aging Clinic at Boston Medical Center. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus on neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. Dr. Alosco completed his post-doctoral studies in neuropsychology via NIH-funded training Awards (T32, F32) at the Boston University Alzheimer’s Disease Research Center and CTE Center. In 2018, he became an Assistant Professor of Neurology at the Boston University School of Medicine and he was promoted to Associate Professor in 2019. Dr. Alosco has >150 peer-reviewed publications, is the PI of multiple NIH funded grants, is the recipient of an NIH/NINDS K23 Award, is the Project Lead of an NIH-funded multisite U54 grant, and serves as aco-investigator on numerous federal and non-federal funded grants. He has also written numerous book chapters, and he is the co-Editor of the Oxford Handbook of Adult Cognitive Disorders which was published by Oxford University Press in 2019.

Dr. Alosco has an active and established research program that has a thematic focus on three areas: (1) the relationship between repetitive head impacts (RHI) and traumatic brain injury (TBI) with a later-life cognitive and neuropsychiatric decline, as well as neurodegenerative disease(s); (2) the contribution of cerebrovascular disease to the clinical and neuropathological expression of CTE, AD, and AD-related dementias (ADRD); and (3) in vivo biomarker development for CTE, AD, and ADRD with a focus on tau PET imaging, structural MRI, and blood-based biomarkers.


Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
09/15/2021 - 08/31/2024 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS122854-01

Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls
08/01/2018 - 04/30/2023 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5K23NS102399-04

In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET
01/01/2021 - 12/31/2022 (Subcontract PI)
The Regents of the University of California, San Francisco NIH NINDS
1R21NS120629-01

Human Tau Imaging
08/01/2020 - 07/31/2022 (Subcontract PI)
The Regents of the University of California, San Francisco Rainwater Char. Fdn


Cerebral perfusion and metabolism in chronic traumatic encephalopathy
11/01/2017 - 10/31/2020 (PI)
The Brigham and Women's Hospital, Inc.


Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy
05/01/2016 - 04/30/2018 (Multi-PI)
PI: Michael Alosco, PhD
NIH/National Institute of Neurological Disorders & Stroke
5F32NS096803-02



Title


Yr Title Project-Sub Proj Pubs
2021 Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms 1RF1NS122854-01
2021 In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET 1R21NS120629-01
2021 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-03-6600
2021 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-04 13
2020 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 5U54NS115266-02-6600
2020 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-03 13
2019 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 5K23NS102399-02 13
2019 Contributions of Exposure to Traumatic Brain Injury and Repetitive Head Impacts to Alzheimer's Disease and Related Dementias and Chronic Traumatic Encephalopathy 1U54NS115266-01-6600
2018 Repetitive Head Impact Exposure and Later-Life White Matter Signal Abnormalities: An Investigation in Former NFL Players, Subjects with Alzheimer's Disease, and Cognitively Normal Controls 1K23NS102399-01A1 13
2017 Magnetic Resonance Spectroscopy as a Biomarker for Chronic Traumatic Encephalopathy 3F32NS096803-01S1 22
Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, OÂ'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Apr 20.View Related Profiles. PMID: 35444054; DOI: 10.1212/WNL.0000000000200304;
     
  2. LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Selection Bias Analysis Supports Dose-Response Relationship between Level of American Football Play and Chronic Traumatic Encephalopathy Diagnosis. Am J Epidemiol. 2022 Apr 16.View Related Profiles. PMID: 35434739; DOI: 10.1093/aje/kwac075;
     
  3. Fang Y, Doyle MF, Alosco ML, Mez J, Satizabal CL, Qiu WQ, Lunetta KL, Murabito JM. Cross-Sectional Association Between Blood Cell Phenotypes, Cognitive Function, and Brain Imaging Measures in the Community-Based Framingham Heart Study. J Alzheimers Dis. 2022 Apr 15.View Related Profiles. PMID: 35431244
     
  4. Phelps A, Alosco ML, Baucom Z, Hartlage K, Palmisano JN, Weuve J, Mez J, Tripodis Y, Stern RA. Association of Playing College American Football With Long-term Health Outcomes and Mortality. JAMA Netw Open. 2022 Apr 01; 5(4):e228775.View Related Profiles. PMID: 35442450; DOI: 10.1001/jamanetworkopen.2022.8775;
     
  5. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles. PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;
     
  6. Daneshvar DH, Alosco ML. In search of cost-effective and non-invasive biomarkers of traumatic brain injury. EBioMedicine. 2022 Feb; 76:103823.View Related Profiles. PMID: 35074628; PMCID: PMC8792432; DOI: 10.1016/j.ebiom.2022.103823;
     
  7. Foley ÉM, Tripodis Y, Yhang E, Koerte IK, Martin BM, Palmisano J, Makris N, Schultz V, Lepage C, Muehlmann M, Wróbel PP, Guenette JP, Cantu RC, Lin AP, Coleman M, Mez J, Bouix S, Shenton ME, Stern RA, Alosco ML. Quantifying and Examining Reserve in Symptomatic Former National Football League Players. J Alzheimers Dis. 2022; 85(2):675-689.View Related Profiles. PMID: 34864657; PMCID: PMC8926024; DOI: 10.3233/JAD-210379;
     
  8. Alosco ML, Mian AZ, Buch K, Farris CW, Uretsky M, Tripodis Y, Baucom Z, Martin B, Palmisano J, Puzo C, Ang TFA, Joshi P, Goldstein LE, Au R, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Huber BR, Alvarez VE, Stern RA, Stein TD, Killiany RJ, McKee AC, Mez J. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE. Alzheimers Res Ther. 2021 12 07; 13(1):193.View Related Profiles. PMID: 34876229; PMCID: PMC8653514; DOI: 10.1186/s13195-021-00928-y;
     
  9. Stathas S, Alvarez VE, Xia W, Nicks R, Meng G, Daley S, Pothast M, Shah A, Kelley H, Esnault C, McCormack R, Dixon E, Fishbein L, Cherry JD, Huber BR, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease. Alzheimers Dement. 2021 Dec 02.View Related Profiles. PMID: 34854540; DOI: 10.1002/alz.12502;
     
  10. Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkina I, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Jun GR, Kowall NW, Stein TD, McKee AC, Killiany R, Qiu WQ, Stern RA, Mez J, Alosco ML. Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimers Dement. 2021 Dec 02.View Related Profiles. PMID: 34854549; DOI: 10.1002/alz.12508;
     
Showing 10 of 165 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 165 publications over 13 distinct years, with a maximum of 25 publications in 2013

YearPublications
20104
20115
201213
201325
201424
201511
201614
201711
201811
201912
202013
202115
20227


Recent (within 3 months)

CTE: The Mysterious Brain Disorder That’s Taken Over the NFL

Radio Health Journal 5/1/2022

Boston University Researchers Study Contact Sports' Impact On Brains

WBZ News Radio 3/8/2022

Older

Kraken broadcaster JT Brown said he plans to donate his brain to CTE research

KOMO News 2/22/2022

White Matter Hyperintensities Linked to Repetitive Head Trauma

Neurology Today 12/16/2021

Could Structural MRI Findings Help Detect CTE During Life?

Diagnostic Imaging 12/16/2021

MRI Might Spot Concussion-Linked CTE in Living Patients

US News & World Report 12/8/2021

MRI Might Spot Concussion-Linked CTE in Living Patient

Health Day 12/8/2021

MRI Key to Diagnosing CTE in Living Patients?

Medscape 12/7/2021

More Years Playing Football, More Brain Lesions on MRI: Study

Health Day 11/29/2021

More Years Playing Football, More Brain Lesions on MRI: Study

US News & World Report 11/29/2021

Men who were in boxing clubs as youngsters may be THREE times as likely to develop Alzheimer's disease, study warns

Daily Mail 11/28/2021

Post-TBI Cognitive Changes 'Strikingly' Similar to Early Parkinson's

Medscape 11/22/2021

Researchers receive $460,000 NIH grant for brain imaging study

News Medical 1/19/2021

Repeated Head Impact Linked With Emotional, Cognitive Problems Later in Life

Psych Congress Network 7/13/2020

Repetitive Hits to the Head Tied To Depression, Poor Cognition in Later Life

Medscape 7/9/2020

Repeat Head Impacts May Lead to Depression Later

Futurity 6/30/2020

Repeated head impacts, brain injury increase risk for depression

UPI 6/26/2020

Hype or horror? The risk of CTE brain disease divides football and medical communities

Fox News 3/4/2020

Ex-NFL Players Six Times More Likely than the General Public to Report Cognitive Problems, Study Finds

The Boston Globe 8/30/2019

Rochester Woman Advocates for Alzheimer's Caregivers

The Union Leader 8/22/2019

Deeper Dive Into CTE, Dementia in Football Reveals New Players

Medscape 8/12/2019

What Years of Playing Football Does to Brain’s White Matter

Futurity 8/12/2019

Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia

Alzforum 8/9/2019

Five New Answers About the Link Between Football, CTE, and Dementia

BU Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

Health Day 8/5/2019

Dementia Tied to White Matter Rarefaction in Football Players With CTE

MedPage Today 8/5/2019

Football Head Trauma Linked Again to Long-Term Brain Damage

U.S. News & World Report 8/5/2019

On the Precipice of Memory Loss: Pursuing Better Diagnostic Tools for Patients with CTE and Other Neurodegenerative Disorders

Genetic Literacy Project 6/13/2019

Dementia-related marker found in former pro athletes with concussion history

Reuters 5/8/2019

For Patients With Memory Loss, Working Towards Better Diagnosis

Undark 5/6/2019

Free Event for Caregivers

Carriage Towne News 4/24/2019

How A Massachusetts Bill Could Affect Local Pop Warner Teams

Newport RI 3/5/2019

California bill would limit tackling during youth practices. Why it has leagues’ support

The Sacramento Bee 1/15/2019

Subconcussive Head Impacts Alter Oculomotor Responses

Reuters Health 12/26/2018

Can Playing Football Lead Your Child To Develop a Disability?

Ruderman Family Foundation 11/5/2018

Starting tackle football early sets kids up for brain problems

Futurity 5/2/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

Playing tackle footall before 12 can lead to long-term consequences

WCVB ABC 5 4/30/2018

2014 Kent State University: David B. Smith Award: Recognition Award for the most outstanding graduate student at Kent State U.
2014 Applied Psychology Center: Publication Award
2013 Applied Psychology Center: Publication Award
2012 American Psychological Association (APA): David Pilon Training Scholarship Award
2012 American Psychological Association (APA): Early Graduate Student Researcher Award
2011-2013 Graduate Student Senate at Kent State University: Domestic Travel Grant Award
2011-2013 Kent State University: Travel Award Applied Psychology Center
2011-2013 Kent State University: Student Travel Award, Department of Psychology
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Neurodegenerative conditions
cerebrovascular disease
head impacts
long-term neurological consequences
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