Dr. Bosmann is an assistant professor at the Boston University School of Medicine. His research interests include pulmonary disorders and their connections to innate immunity, host-pathogen interactions, and inflammation.
Assistant Professor
Boston University School of Medicine
Pathology & Laboratory Medicine
Member
Boston University
Pulmonary Center
Member
Boston University
Evans Center for Interdisciplinary Biomedical Research
Member
Boston University
Genome Science Institute
Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences
2014 European Hematology Association:
Clinical Research Fellowship
2013 55th ASH Annual Meeting:
Abstract Achievement Award
2004 Allianz Health Insurance Corp:
MD student travel award
This tab shows grant data from BMC Sponsored Research. It includes:
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Role reversal of MAVS in bacterial sepsis08/15/2018 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL141513-02
New genetic models for C5a receptors07/01/2018 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL139641-02
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Lindstrom-Vautrin J, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020 Sep 18.View Related Profiles. PMID: 32979316
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Roewe J, Stavrides G, Strueve M, Sharma A, Marini F, Mann A, Smith SA, Kaya Z, Strobl B, Mueller M, Reinhardt C, Morrissey JH, Bosmann M. Bacterial polyphosphates interfere with the innate host defense to infection. Nat Commun. 2020 08 12; 11(1):4035. PMID: 32788578
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Bosmann M. Complement Activation during Critical Illness: Current Findings and an Outlook in the Era of COVID-19. Am J Respir Crit Care Med. 2020 07 15; 202(2):163-165. PMID: 32437622
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Ascher S, Wilms E, Pontarollo G, Formes H, Bayer F, Müller M, Malinarich F, Grill A, Bosmann M, Saffarzadeh M, Brandão I, Groß K, Kiouptsi K, Kittner JM, Lackner KJ, Jurk K, Reinhardt C. Gut Microbiota Restricts NETosis in Acute Mesenteric Ischemia-Reperfusion Injury. Arterioscler Thromb Vasc Biol. 2020 09; 40(9):2279-2292. PMID: 32611241
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Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles. PMID: 32637964
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Bochenek ML, Leidinger C, Rosinus NS, Gogiraju R, Guth S, Hobohm L, Jurk K, Mayer E, Münzel T, Lankeit M, Bosmann M, Konstantinides S, Schäfer K. Activated Endothelial TGFß1 Signaling Promotes Venous Thrombus Nonresolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension. Circ Res. 2020 01 17; 126(2):162-181. PMID: 31747868
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Alflen A, Aranda Lopez P, Hartmann AK, Maxeiner J, Bosmann M, Sharma A, Platten J, Ries F, Beckert H, Ruf W, Radsak MP. Neutrophil extracellular traps impair fungal clearance in a mouse model of invasive pulmonary aspergillosis. Immunobiology. 2020 01; 225(1):151867. PMID: 31761474
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Gawish R, Bulat T, Biaggio M, Lassnig C, Bago-Horvath Z, Macho-Maschler S, Poelzl A, Simonovic N, Prchal-Murphy M, Rom R, Amenitsch L, Ferrarese L, Kornhoff J, Lederer T, Svinka J, Eferl R, Bosmann M, Kalinke U, Stoiber D, Sexl V, Krmpotic A, Jonjic S, Müller M, Strobl B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Rep. 2019 02 26; 26(9):2394-2406.e5. PMID: 30811989
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Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling. Mol Cell Proteomics. 2019 04; 18(4):669-685. PMID: 30635358
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Sharma A, Steven S, Bosmann M. The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators. Biochem Biophys Res Commun. 2019 01 29; 509(1):188-193. PMID: 30579593
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Kröller-Schön S, Daiber A, Steven S, Oelze M, Frenis K, Kalinovic S, Heimann A, Schmidt FP, Pinto A, Kvandova M, Vujacic-Mirski K, Filippou K, Dudek M, Bosmann M, Klein M, Bopp T, Hahad O, Wild PS, Frauenknecht K, Methner A, Schmidt ER, Rapp S, Mollnau H, Münzel T. Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation. Eur Heart J. 2018 10 07; 39(38):3528-3539. PMID: 29905797
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Alflen A, Prüfer S, Ebner K, Reuter S, Lopez PA, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP. Author Correction: ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Sci Rep. 2018 Sep 26; 8(1):14599. PMID: 30254380
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Schütz E, Bochenek ML, Riehl DR, Bosmann M, Münzel T, Konstantinides S, Schäfer K. Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thromb Haemost. 2017 Aug 31; 117(9):1782-1797. PMID: 28726976; DOI: 10.1160/TH17-02-0112;
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Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C. Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PLoS One. 2017; 12(8):e0183590.View Related Profiles. PMID: 28837614
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Roewe J, Higer M, Riehl DR, Gericke A, Radsak MP, Bosmann M. Neuroendocrine Modulation of IL-27 in Macrophages. J Immunol. 2017 Oct 01; 199(7):2503-2514. PMID: 28835457
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Alflen A, Prüfer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP. ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Sci Rep. 2017 08 03; 7(1):7184. PMID: 28775254
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Fattahi F, Kalbitz M, Malan EA, Abe E, Jajou L, Huber-Lang MS, Bosmann M, Russell MW, Zetoune FS, Ward PA. Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB J. 2017 Sep; 31(9):4129-4139. PMID: 28572445
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Ward PA, Fattahi F, Bosmann M. New Insights into Molecular Mechanisms of Immune Complex-Induced Injury in Lung. Front Immunol. 2016; 7:86. PMID: 27014266
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Taddonio MA, Dolgachev V, Bosmann M, Ward PA, Su G, Wang SC, Hemmila MR. Influence of lipopolysaccharide-binding protein on pulmonary inflammation in gram-negative pneumonia. Shock. 2015 Jun; 43(6):612-9. PMID: 25643011
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Russkamp NF, Ruemmler R, Roewe J, Moore BB, Ward PA, Bosmann M. Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin. FASEB J. 2015 Sep; 29(9):3762-72. PMID: 25999468
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Kalbitz M, Grailer JJ, Fattahi F, Jajou L, Herron TJ, Campbell KF, Zetoune FS, Bosmann M, Sarma JV, Huber-Lang M, Gebhard F, Loaiza R, Valdivia HH, Jalife J, Russell MW, Ward PA. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J. 2015 May; 29(5):2185-93. PMID: 25681459
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Bosmann M, Russkamp NF, Strobl B, Roewe J, Balouzian L, Pache F, Radsak MP, van Rooijen N, Zetoune FS, Sarma JV, Núñez G, Müller M, Murray PJ, Ward PA. Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J Immunol. 2014 Dec 01; 193(11):5668-77. PMID: 25348624
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Weber M, Rudolph B, Stein P, Yogev N, Bosmann M, Schild H, Radsak MP. Host-derived CD8? dendritic cells protect against acute graft-versus-host disease after experimental allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2014 Nov; 20(11):1696-704. PMID: 25132527
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Bosmann M, Ward PA. Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opin Ther Targets. 2014 Jun; 18(6):703-14. PMID: 24670033
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Bosmann M, Strobl B, Kichler N, Rigler D, Grailer JJ, Pache F, Murray PJ, Müller M, Ward PA. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol. 2014 Jul; 96(1):123-31. PMID: 24604832
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Prüfer S, Weber M, Stein P, Bosmann M, Stassen M, Kreft A, Schild H, Radsak MP. Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice. Immunobiology. 2014 Feb; 219(2):87-96. PMID: 24054721
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Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J. 2013 Dec; 27(12):5010-21. PMID: 23982144
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Bosmann M, Ward PA. Modulation of inflammation by interleukin-27. J Leukoc Biol. 2013 Dec; 94(6):1159-65. PMID: 23904441
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Bosmann M, Haggadone MD, Zetoune FS, Sarma JV, Ward PA. The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur J Immunol. 2013 Jul; 43(7):1907-13. PMID: 23575697
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Bosmann M, Grailer JJ, Russkamp NF, Ruemmler R, Zetoune FS, Sarma JV, Ward PA. CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury. Shock. 2013 May; 39(5):447-52. PMID: 23481504
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Bosmann M, Meta F, Ruemmler R, Haggadone MD, Sarma JV, Zetoune FS, Ward PA. Regulation of IL-17 family members by adrenal hormones during experimental sepsis in mice. Am J Pathol. 2013 Apr; 182(4):1124-30. PMID: 23499051
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Grailer JJ, Bosmann M, Ward PA. Regulatory effects of C5a on IL-17A, IL-17F, and IL-23. Front Immunol. 2012; 3:387. PMID: 23316190
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Bosmann M, Ward PA. The inflammatory response in sepsis. Trends Immunol. 2013 Mar; 34(3):129-36. PMID: 23036432
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Bosmann M, Russkamp NF, Ward PA. Fingerprinting of the TLR4-induced acute inflammatory response. Exp Mol Pathol. 2012 Dec; 93(3):319-23. PMID: 22981705
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Ward PA, Bosmann M. A historical perspective on sepsis. Am J Pathol. 2012 Jul; 181(1):2-7. PMID: 22642906
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Bosmann M, Ward PA. Therapeutic potential of targeting IL-17 and IL-23 in sepsis. Clin Transl Med. 2012 Apr 27; 1(1):4. PMID: 23369364
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Bosmann M, Haggadone MD, Hemmila MR, Zetoune FS, Sarma JV, Ward PA. Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages. J Immunol. 2012 May 15; 188(10):5086-93. PMID: 22491257
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Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA. Anti-inflammatory effects of ß2 adrenergic receptor agonists in experimental acute lung injury. FASEB J. 2012 May; 26(5):2137-44. PMID: 22318967
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Bosmann M, Ward PA. Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol. 2012; 946:147-59. PMID: 21948367
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Bosmann M, Sarma JV, Atefi G, Zetoune FS, Ward PA. Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J. 2012 Apr; 26(4):1640-51. PMID: 22202675
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Bosmann M, Russkamp NF, Patel VR, Zetoune FS, Sarma JV, Ward PA. The outcome of polymicrobial sepsis is independent of T and B cells. Shock. 2011 Oct; 36(4):396-401. PMID: 21701414
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Bosmann M, Patel VR, Russkamp NF, Pache F, Zetoune FS, Sarma JV, Ward PA. MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FASEB J. 2011 Dec; 25(12):4222-32. PMID: 21859896
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Atefi G, Zetoune FS, Herron TJ, Jalife J, Bosmann M, Al-Aref R, Sarma JV, Ward PA. Complement dependency of cardiomyocyte release of mediators during sepsis. FASEB J. 2011 Jul; 25(7):2500-8. PMID: 21478262
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Bosmann M, Kössler J, Stolz H, Walter U, Knop S, Steigerwald U. Detection of serum free light chains: the problem with antigen excess. Clin Chem Lab Med. 2010 Oct; 48(10):1419-22. PMID: 20626301
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Bosmann M, Schreiner O, Galle PR. Coexistence of Cullen's and Grey Turner's signs in acute pancreatitis. Am J Med. 2009 Apr; 122(4):333-4. PMID: 19332225
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Bosmann M, Schwarting A. [Non-invasive monitoring of fluid balance]. Dtsch Med Wochenschr. 2009 Feb; 134(9):421-4. PMID: 19224429
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Hofstetter C, Flondor M, Boost KA, Koehler P, Bosmann M, Pfeilschifter J, Zwissler B, Mühl H. A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats. Int Immunopharmacol. 2005 Sep; 5(10):1519-22. PMID: 16023603
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Nascimbeni M, Mizukoshi E, Bosmann M, Major ME, Mihalik K, Rice CM, Feinstone SM, Rehermann B. Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees. J Virol. 2003 Apr; 77(8):4781-93. PMID: 12663785
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Paulukat J, Bosmann M, Nold M, Garkisch S, Kämpfer H, Frank S, Raedle J, Zeuzem S, Pfeilschifter J, Mühl H. Expression and release of IL-18 binding protein in response to IFN-gamma. J Immunol. 2001 Dec 15; 167(12):7038-43. PMID: 11739524
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Mühl H, Chang JH, Huwiler A, Bosmann M, Paulukat J, Ninic R, Nold M, Hellmuth M, Pfeilschifter J. Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways. Free Radic Biol Med. 2000 Nov 15; 29(10):969-80. PMID: 11084285
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Mühl H, Kämpfer H, Bosmann M, Frank S, Radeke H, Pfeilschifter J. Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells. Biochem Biophys Res Commun. 2000 Jan 27; 267(3):960-3. PMID: 10673399
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2000 | 2 |
| 2001 | 1 |
| 2003 | 1 |
| 2005 | 1 |
| 2009 | 2 |
| 2010 | 1 |
| 2011 | 4 |
| 2012 | 7 |
| 2013 | 7 |
| 2014 | 4 |
| 2015 | 3 |
| 2016 | 1 |
| 2017 | 5 |
| 2018 | 3 |
| 2019 | 4 |
| 2020 | 5 |