Mark Grinstaff, PhD

Mark W. Grinstaff is a Distinguished Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials and the Director of the Nanotechnology Innovation Center at Boston University.

Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher- Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is an author or co-author on more than 225 peer-reviewed manuscripts, given more than 300 oral presentations, and an inventor or co- inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings.

Mark's current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair. His group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of their current research projects, they are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, they are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, they are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, they are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Mark is a co-founder of several companies that are commercializing his ideas, and he has several products being sold and used in the clinic.

Director
Boston University
Nanotechnology Innovation Center (BUnano)


Professor
Boston University College of Engineering
Biomedical Engineering


Professor
Boston University School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

Associate Director for Engineering & Sciences
Boston University
BU-BMC Cancer Center


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2012 National Academy of Inventors Charter Fellow
2012 Kern Faculty Fellow
2011 Stevenson Biomaterials Lecturer, Syracuse Biomaterials Institute, Syracuse University
2010 Boston University Innovator of the Year
2010 Elected to AIMBE (College of Fellows of the American Institute for Medical & Biomedical Engineering)
2010 Professeur Invité and Certificat sur Honneur, Université de Bordeaux (Bordeaux II)
2009 COE Distinguished Faculty Fellow (5-year Endowed Fellowship)
2008 Edward M. Kennedy Award for Health Care Innovation
2007 Professeurr Invité and Certificat sur Honneur, Université de la Maditerranée (Aix-Marseille II)
2006 Elected Fellow of the American Academy of Nanomedicine
2001 3M Non-Tenured Faculty Award
2001 Johnson and Johnson Focused Giving Grant Recipient
2000 Camille Dreyfus Teacher-Scholar
2000 Alfred P. Sloan Research Fellowship
1999 Pew Scholar in the Biomedical Sciences
1999 NSF Career Award
1998 Whitaker Foundation Grant Recipient
1994 ACS Nobel Laureate Signature Award
1993 NIH Postdoctoral Fellowship
1991 T.S. Piper Award for Outstanding Inorganic Research
1990 The ACS Fellowship of the Colloid & Surface Division (Sponsored by Procter & Gamble)
1989 University of Illinois Chemistry Department Fellowship


SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNG TUMOR RECURRENCE
02/15/2019 - 01/31/2024 (PI)
NIH/National Cancer Institute
5R01CA232708-03

Optimization of Nanoparticle Tumor-Localization and Drug-Loading for Treating Mesothelioma 1 R01 CA232056-01
02/01/2019 - 01/31/2024 (PI)
NIH/National Cancer Institute
5R01CA232056-03

Tumor Specific Delivery of Verticillin A Overcomes Epigenetic Silencing Responsible for Drug Resistance
04/01/2018 - 03/31/2023 (PI)
NIH/National Cancer Institute
5R01CA227433-04

A Biomaterials Strategy to Maintain Functionality in Osteoarthritic Cartilage
12/15/2019 - 11/30/2022 (PI)
National Science Foundation
DMR-1905673

Relaxin-2 as a Novel Protein Therapeutic for the Treatment of Shoulder Arthrofibrosis
09/10/2020 - 08/31/2022 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R56AR075788-01A1

Translational Research in Biomaterials
09/09/2020 - 08/31/2022 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5T32EB006359-12

Prolonged Intranasal Delivery of Ketamine Using Mucoadhesive Particles
06/01/2018 - 05/31/2022 (Multi-PI)
PI: Mark Grinstaff, PhD
Uniformed Services University of the Health Sciences Federal Medical School


R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD
04/01/2019 - 01/31/2022 (PI)
NIH/National Institute on Aging
5R21AG063373-02

Bioadhesive Form in Place Patch Development
05/03/2019 - 12/31/2021 (PI)
Boston Scientific Corporation


Prolonged Intranasal Delivery of Ketamine Using Mucoadhesive Particles
06/01/2018 - 05/31/2021 (Multi-PI)
PI: Mark Grinstaff, PhD
Uniformed Services University Health Sciences HJF AdvOfMilitaryMed


Showing 10 of 41 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Precise tumor targeting with logic CAR circuits 1U01CA265713-01
2021 Translational Research in Biomaterials 5T32EB006359-12 42
2021 SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNG TUMOR RECURRENCE 5R01CA232708-03
2021 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 5R01CA232056-03
2021 TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCE 5R01CA227433-04 7
2020 Relaxin-2 as a Novel Protein Therapeutic for the Treatment of Shoulder Arthrofibrosis 1R56AR075788-01A1
2020 Translational Research in Biomaterials 2T32EB006359-11 42
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 5R21AG063373-02
Showing 10 of 87 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lu C, Yang D, Klement JD, Colson YL, Oberlies NH, Pearce CJ, Colby AH, Grinstaff MW, Ding HF, Shi H, Liu K. G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes. J Immunother Cancer. 2022 01; 10(1). PMID: 35017152
     
  2. Lawson T, Joenathan A, Patwa A, Snyder BD, Grinstaff MW. Tantalum Oxide Nanoparticles for the Quantitative Contrast-Enhanced Computed Tomography of Ex Vivo Human Cartilage: Assessment of Biochemical Composition and Biomechanics. ACS Nano. 2021 12 28; 15(12):19175-19184. PMID: 34882411
     
  3. Petersen A, Chu NQ, Fitzgerald DM, McCaslin EZ, Blessing WA, Colby AH, Colson YL, Grinstaff MW. Sustainable glycerol terpolycarbonates as temporary bioadhesives. Biomater Sci. 2021 Dec 07; 9(24):8366-8372. PMID: 34787119
     
  4. Boos MA, Grinstaff MW, Lamandé SR, Stok KS. Contrast-Enhanced Micro-Computed Tomography for 3D Visualization and Quantification of Glycosaminoglycans in Different Cartilage Types. Cartilage. 2021 12; 13(2_suppl):486S-494S. PMID: 34696603
     
  5. Cook KA, Naguib N, Kirsch J, Hohl K, Colby AH, Sheridan R, Rodriguez EK, Nazarian A, Grinstaff MW. In situ gelling and dissolvable hydrogels for use as on-demand wound dressings for burns. Biomater Sci. 2021 Oct 12; 9(20):6842-6850. PMID: 34486599; PMCID: PMC8511343; DOI: 10.1039/d1bm00711d;
     
  6. Varghese M, Rokosh RS, Haller CA, Chin SL, Chen J, Dai E, Xiao R, Chaikof EL, Grinstaff MW. Sulfated poly-amido-saccharides (sulPASs) are anticoagulants in vitro and in vivo. Chem Sci. 2021 Oct 06; 12(38):12719-12725. PMID: 34703558; PMCID: PMC8494039; DOI: 10.1039/d1sc02302k;
     
  7. Song J, Korunes-Miller J, Banerji R, Wu Y, Fazeli S, Zheng H, Orr B, Morgan E, Andry C, Henderson J, Miller NS, White A, Grinstaff MW. On-Site, On-Demand 3D-Printed Nasopharyngeal Swabs to Improve the Access of Coronavirus Disease-19 Testing. Glob Chall. 2021 Nov; 5(11):2100039.View Related Profiles. PMID: 34754507; PMCID: PMC8562062; DOI: 10.1002/gch2.202100039;
     
  8. Gao X, Patwa AN, Deng Z, Utsunomiya H, Grinstaff MW, Ruzbarsky JJ, Snyder BD, Ravuri S, Philippon MJ, Huard J. Influence of fixation on CA4+ contrast enhanced microCT of articular cartilage and subsequent feasibility for histological evaluation. Am J Transl Res. 2021; 13(8):8921-8937. PMID: 34540005; PMCID: PMC8430171
     
  9. Kroupa KR, Wu MI, Zhang J, Jensen M, Wong W, Engiles JB, Schaer TP, Grinstaff MW, Snyder BD, Bergholt MS, Albro MB. Raman needle arthroscopy for in vivo molecular assessment of cartilage. J Orthop Res. 2021 Aug 09. PMID: 34370873
     
  10. Cook K, Naguib N, Price CE, Katharios S, Kirsch J, Cortes K, Hohl K, O'Toole GA, Grinstaff MW. Temporary In Situ Hydrogel Dressings for Colon Polypectomies. ACS Biomater Sci Eng. 2021 09 13; 7(9):4362-4370. PMID: 34342427
     
Showing 10 of 350 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 350 publications over 33 distinct years, with a maximum of 26 publications in 2016

YearPublications
19901
19912
19922
19933
19944
19953
19962
19972
19982
19998
20006
20016
20029
20035
20047
20059
200612
20076
200817
200910
201014
201118
201219
201319
201412
201516
201626
201719
201823
201925
202021
202121
20221

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomaterials
Drug Delivery
Macromolecular Chemistry and Engineering
Nanodevices
Self-Assembly
Tissue Engineering
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Boston MA 02215
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