Mark Grinstaff, PhD

Mark W. Grinstaff is a Distinguished Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials and the Director of the Nanotechnology Innovation Center at Boston University.

Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher- Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is an author or co-author on more than 225 peer-reviewed manuscripts, given more than 300 oral presentations, and an inventor or co- inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings.

Mark's current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair. His group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of their current research projects, they are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, they are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, they are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, they are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Mark is a co-founder of several companies that are commercializing his ideas, and he has several products being sold and used in the clinic.

Professor
Boston University College of Arts and Sciences
Chemistry


Director
Boston University
Nanotechnology Innovation Center (BUnano)


Professor
Boston University College of Engineering
Biomedical Engineering


Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

Associate Director for Engineering & Sciences
Boston University
BU-BMC Cancer Center


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Translational Research in Biomaterials
09/01/2022 - 08/31/2027 (Multi-PI)
PI: Mark Grinstaff, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
3T32EB006359-14S1

Supratherapeutic PTX Buttresses Reduce Locoregional Recurrence Rates Following Surgery for Soft Tissue Sarcomas
08/01/2022 - 07/31/2027 (Multi-PI)
PI: Mark Grinstaff, PhD
The Brigham and Women's Hospital, Inc. NIH NCI
1R01CA272637-01

The Conundrum of Absentee Receptors: Efficacy Potentiation Through Drug-Receptor Modulation
09/21/2022 - 06/30/2027 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R01AR081264-01

Arthroscopic Raman Monitoring of Cartilage Content for PTOA Diagnosis and Chondroregenerative Treatment Response
08/02/2022 - 05/31/2027 (Co-Investigator)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR081393-02

Sustained Release Relaxin-2 for the Treatment of Frozen Shoulder
08/01/2022 - 05/31/2027 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR079489-02

A Bio-inspired Latent TGF-beta Conjugated Scaffold for Patient-specific Cartilage Regeneration
06/01/2022 - 05/31/2027 (Co-Investigator)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR078299-02

Precise tumor targeting with logic CAR circuits
09/17/2021 - 08/31/2026 (Multi-PI)
PI: Mark Grinstaff, PhD
NIH/National Cancer Institute
5U01CA265713-02

Sulfated Poly-Amido-Saccharide (sulPAS) Biomaterials as Anticoagulants
07/01/2022 - 06/30/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL164650-02

Biodegradable, Biocompatible Pressure Sensitive Adhesives
08/05/2022 - 04/30/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL159644-02

Poly(glycerol carbonate) pressure sensitive adhesives for the in vivo closure of alveolar pleural fistulae
05/16/2022 - 11/15/2025 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F31HL163917-02

Showing 10 of 58 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Biodegradable, Biocompatible Pressure Sensitive Adhesives 5R01HL159644-03
2023 The Conundrum of Absentee Receptors: Efficacy Potentiation Through Drug-Receptor Modulation 5R01AR081264-02
2023 Biodegradable, Biocompatible Pressure Sensitive Adhesives 5R01HL159644-02
2023 Supratherapeutic PTX Buttresses Reduce Locoregional Recurrence Rates Following Surgery for Soft Tissue Sarcomas 5R01CA272637-02
2023 Sustained Release Relaxin-2 for the Treatment of Frozen Shoulder 5R01AR079489-02
2023 Sulfated Poly-Amido-Saccharide (sulPAS) Biomaterials as Anticoagulants 5R01HL164650-02
2023 R21: A novel antibody-drug conjugate for treatment of squamous cell lung carcinoma 5R21CA273645-02
2023 Precise tumor targeting with logic CAR circuits 5U01CA265713-03
2023 SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNGTUMOR RECURRENCE 5R01CA232708-05
2023 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADINGFOR TREATING MESOTHELIOMA 5R01CA232056-05
Showing 10 of 104 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Stewart HL, Gilbert D, Stefanovski D, Garman Z, Albro MB, Bais M, Grinstaff MW, Snyder BD, Schaer TP. A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models. Osteoarthritis Cartilage. 2024 May; 32(5):501-513. PMID: 38408635
     
  2. Sabatelle RC, Chu NQ, Blessing W, Kharroubi H, Bressler E, Tsai L, Shih A, Grinstaff MW, Colson Y. Decreased Lung Metastasis in Triple Negative Breast Cancer Following Locally Delivered Supratherapeutic Paclitaxel-Loaded Polyglycerol Carbonate Nanoparticle Therapy. Biomacromolecules. 2024 Mar 11; 25(3):1800-1809. PMID: 38380618
     
  3. Jäntti J, Joenathan A, Fugazzola M, Tuppurainen J, Honkanen JTJ, Töyräs J, van Weeren R, Snyder BD, Grinstaff MW, Matikka H, Mäkelä JTA. Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations. Osteoarthritis Cartilage. 2024 Mar; 32(3):299-309. PMID: 38061579
     
  4. Cooper BG, DeMoya CD, Sikes KJ, Frisbie DD, Phillips N, Nelson BB, McIlwraith CW, Kawcak CE, Goodrich LR, Snyder BD, Grinstaff MW. A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear architecture. Biomater Sci. 2023 Nov 07; 11(22):7339-7345.View Related Profiles. PMID: 37847186; DOI: 10.1039/d3bm00753g;
     
  5. Grazon C, Garanger E, Lalanne P, Ibarboure E, Galagan JE, Grinstaff MW, Lecommandoux S. Transcription-Factor-Induced Aggregation of Biomimetic Oligonucleotide-b-Protein Micelles. Biomacromolecules. 2023 Nov 13; 24(11):5027-5034.View Related Profiles. PMID: 37877162
     
  6. Mahvi DA, Korunes-Miller J, Bordeianu C, Chu NQ, Geller AD, Sabatelle R, Berry S, Hung YP, Colson YL, Grinstaff MW, Raut CP. High dose, dual-release polymeric films for extended surgical bed paclitaxel delivery. J Control Release. 2023 Nov; 363:682-691. PMID: 37776906; PMCID: PMC10990290; DOI: 10.1016/j.jconrel.2023.09.048;
     
  7. McGee JE, Kirsch JR, Kenney D, Chavez E, Shih TY, Douam F, Wong WW, Grinstaff MW. Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA. bioRxiv. 2023 Sep 17.View Related Profiles. PMID: 37745375; PMCID: PMC10516017; DOI: 10.1101/2023.09.15.557994;
     
  8. Orava H, Paakkari P, Jäntti J, Honkanen MKM, Honkanen JTJ, Virén T, Joenathan A, Tanska P, Korhonen RK, Grinstaff MW, Töyräs J, Mäkelä JTA. Triple contrast computed tomography reveals site-specific biomechanical differences in the human knee joint-A proof of concept study. J Orthop Res. 2024 Feb; 42(2):415-424. PMID: 37593815
     
  9. Zhang S, Grifno G, Passaro R, Regan K, Zheng S, Hadzipasic M, Banerji R, O'Connor L, Chu V, Kim SY, Yang J, Shi L, Karrobi K, Roblyer D, Grinstaff MW, Nia HT. Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission. Nat Biomed Eng. 2023 Nov; 7(11):1473-1492.View Related Profiles. PMID: 37640900; PMCID: PMC10836235; DOI: 10.1038/s41551-023-01080-8;
     
  10. Bressler EM, Adams S, Liu R, Colson YL, Wong WW, Grinstaff MW. Boolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics. Clin Transl Med. 2023 Jul; 13(7):e1244. PMID: 37386762; PMCID: PMC10310979; DOI: 10.1002/ctm2.1244;
     
Showing 10 of 393 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 393 publications over 35 distinct years, with a maximum of 26 publications in 2016 and 2019

YearPublications
19901
19912
19922
19933
19944
19953
19962
19972
19982
19998
20006
20016
20029
20035
20047
20059
200612
20076
200817
200910
201014
201118
201219
201319
201412
201517
201626
201719
201824
201926
202021
202121
202224
202315
20242


Self-copying RNA vaccine wins first full approval: what’s next?

Nature 12/6/2023

BU Ignition Awards to Accelerate Products for Repairing Damaged Teeth, Fighting Cancer, Boosting Reading Skills, and More

The Brink 9/19/2023

Inventor Mark Grinstaff Named an AAAS Fellow

BU Today 2/14/2022

2021 AAAS Fellows

AAAS 1/24/2022

Simple process unlocks DNA’s potential to make biomaterials

Chemical & Engineering News 6/19/2020

Sustainable adhesives of the future won’t stick around

National Science Foundation 3/23/2020

Band-Aid Adhesive Replacement Won’t Ruin The Planet

Futurity 12/18/2019

Research Reveals a Natural Pregnancy Hormone Could Relax a Locked-up Joint

R&D Magazine 6/7/2019

Pregnancy Hormone Loosens ‘Frozen Shoulder’

Futurity 6/4/2019

Crossing the Scientific Aisle to Advance Tissue Engineering

BU Today 1/18/2019

Researchers develop self-lubricating condom to stem spread of STDs

Plastics Today 10/23/2018

A Self-Lubricating Condom is Almost Here. Will It Change Sex Forever?

Instinct 10/23/2018

This self-lubing condom lasts for 1,000 thrusts–and could change sex

Fast Company 10/22/2018

Boston University scientists develop new condom they hope will encourage broader use

The Boston Globe 10/19/2018

Scientists created a condom that self-lubricates during sex. You’re welcome

Digital Trends 10/18/2018

E-cigarettes Prevent Wound Healing

The Daily Mail 10/18/2018

E-cigarettes Slowed Wound Healing in Animal Study

HealthDay 10/18/2018

New Self-Lubricating Condom Would Revolutionize Safe Sex

BU Today 10/18/2018

New self-lubricating condoms could boost their use, prevent STDs

CNN 10/17/2018

Self-lubricating condom design may encourage safe sex

The Guardian 10/16/2018

2012 National Academy of Inventors Charter Fellow
2012 Kern Faculty Fellow
2011 Stevenson Biomaterials Lecturer, Syracuse Biomaterials Institute, Syracuse University
2010 Boston University Innovator of the Year
2010 Elected to AIMBE (College of Fellows of the American Institute for Medical & Biomedical Engineering)
2010 Professeur Invité and Certificat sur Honneur, Université de Bordeaux (Bordeaux II)
2009 COE Distinguished Faculty Fellow (5-year Endowed Fellowship)
2008 Edward M. Kennedy Award for Health Care Innovation
2007 Professeurr Invité and Certificat sur Honneur, Université de la Maditerranée (Aix-Marseille II)
2006 Elected Fellow of the American Academy of Nanomedicine
2001 3M Non-Tenured Faculty Award
2001 Johnson and Johnson Focused Giving Grant Recipient
2000 Camille Dreyfus Teacher-Scholar
2000 Alfred P. Sloan Research Fellowship
1999 Pew Scholar in the Biomedical Sciences
1999 NSF Career Award
1998 Whitaker Foundation Grant Recipient
1994 ACS Nobel Laureate Signature Award
1993 NIH Postdoctoral Fellowship
1991 T.S. Piper Award for Outstanding Inorganic Research
1990 The ACS Fellowship of the Colloid & Surface Division (Sponsored by Procter & Gamble)
1989 University of Illinois Chemistry Department Fellowship
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomaterials
Drug Delivery
Macromolecular Chemistry and Engineering
Nanodevices
Self-Assembly
Tissue Engineering
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590 Commonwealth Ave
Boston MA 02215
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