Mark Grinstaff, PhD

Mark W. Grinstaff is a Distinguished Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials and the Director of the Nanotechnology Innovation Center at Boston University.

Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher- Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is an author or co-author on more than 225 peer-reviewed manuscripts, given more than 300 oral presentations, and an inventor or co- inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings.

Mark's current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair. His group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of their current research projects, they are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, they are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, they are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, they are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Mark is a co-founder of several companies that are commercializing his ideas, and he has several products being sold and used in the clinic.

Boston University
Nanotechnology Innovation Center (BUnano)

Boston University College of Engineering
Biomedical Engineering

Boston University School of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

2012 National Academy of Inventors Charter Fellow
2012 Kern Faculty Fellow
2011 Stevenson Biomaterials Lecturer, Syracuse Biomaterials Institute, Syracuse University
2010 Boston University Innovator of the Year
2010 Elected to AIMBE (College of Fellows of the American Institute for Medical & Biomedical Engineering)
2010 Professeur Invité and Certificat sur Honneur, Université de Bordeaux (Bordeaux II)
2009 COE Distinguished Faculty Fellow (5-year Endowed Fellowship)
2008 Edward M. Kennedy Award for Health Care Innovation
2007 Professeurr Invité and Certificat sur Honneur, Université de la Maditerranée (Aix-Marseille II)
2006 Elected Fellow of the American Academy of Nanomedicine
2001 3M Non-Tenured Faculty Award
2001 Johnson and Johnson Focused Giving Grant Recipient
2000 Camille Dreyfus Teacher-Scholar
2000 Alfred P. Sloan Research Fellowship
1999 Pew Scholar in the Biomedical Sciences
1999 NSF Career Award
1998 Whitaker Foundation Grant Recipient
1994 ACS Nobel Laureate Signature Award
1993 NIH Postdoctoral Fellowship
1991 T.S. Piper Award for Outstanding Inorganic Research
1990 The ACS Fellowship of the Colloid & Surface Division (Sponsored by Procter & Gamble)
1989 University of Illinois Chemistry Department Fellowship

Tumor Specific Delivery of Verticillin A Overcomes Epigenetic Silencing Responsible for Drug Resistance
04/01/2018 - 03/31/2023 (PI)
NIH/National Cancer Institute

Basic Research on New Ionic Electrolytes: Characterization
01/01/2016 - 12/31/2020 (PI)

Translational Research in Biomaterials
09/01/2015 - 08/31/2020 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering

Dissolvable Hydrogel dressing for the treatment of burns
02/01/2016 - 12/31/2019 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering

Synthesis, Characterization, and Evaluation of Polymeric Tissue Lubricants
07/08/2014 - 06/30/2019 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Efficacy and safely of a novel, implantable drug-eluting film in sarcoma
01/14/2016 - 11/30/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NIBIB

Basic Research on New Ionic Liquid Electrolytes: Synthesis
01/01/2016 - 09/14/2018 (PI)

Glycerol Polycarbonates as New Biomaterials
08/01/2015 - 07/31/2018 (PI)
National Science Foundation

Organic Biosensors for Personal Physiologic Monitoring
04/11/2016 - 10/10/2017 (Co-PI)
PI: James E. Galagan, PhD
Department of Defense/DARPA

CBL Graduate Fellowship for Samantha Berry
09/01/2015 - 08/31/2017 (PI)
The Henry Luce Foundation, Inc.

Showing 10 of 29 results. Show All Results

Yr Title Project-Sub Proj Pubs
2018 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-03 2
2018 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma 5R01EB017722-03 2
2017 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-02 2
2017 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma 5R01EB017722-02 2
2017 Synthesis, Characterization, and Evaluation of Polymeric Tissue Lubricants 5R01AR066621-04
2017 Translational Research in Biomaterials 5T32EB006359-08 10
2016 Dissolvable Hydrogel Dressing for the Treatment of Burns 1R01EB021308-01 2
2016 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma 1R01EB017722-01A1 2
2016 Synthesis, Characterization, and Evaluation of Polymeric Tissue Lubricants 5R01AR066621-03
Showing 10 of 57 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Cooper BG, Catalina Bordeianu, Nazarian A, Snyder BD, Grinstaff MW. Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues. Biomaterials. 2018 Jul 26; 181:210-226.View Related Profiles. PMID: 30092370.
  2. Reynolds DS, Bougher KM, Letendre JH, Fitzgerald SF, Gisladottir UO, Grinstaff MW, Zaman MH. Mechanical confinement via a PEG/Collagen interpenetrating network inhibits behavior characteristic of malignant cells in the triple negative breast cancer cell line MDA.MB.231. Acta Biomater. 2018 Jul 18.View Related Profiles. PMID: 30030173.
  3. Chapman Varela J, Sankar K, Hino A, Lin X, Chang WS, Coker D, Grinstaff M. Piperidinium ionic liquids as electrolyte solvents for sustained high temperature supercapacitor operation. Chem Commun (Camb). 2018 May 29; 54(44):5590-5593.View Related Profiles. PMID: 29766179.
  4. Ekladious I, Liu R, Varongchayakul N, Mejia Cruz LA, Todd DA, Zhang H, Oberlies NH, Padera RF, Colson YL, Grinstaff MW. Reinforcement of polymeric nanoassemblies for ultra-high drug loadings, modulation of stiffness and release kinetics, and sustained therapeutic efficacy. Nanoscale. 2018 May 10; 10(18):8360-8366. PMID: 29717728.
  5. Christadore L, Grinstaff MW, Schaus SE. Fluorescent Dendritic Micro-Hydrogels: Synthesis, Analysis and Use in Single-Cell Detection. Molecules. 2018 Apr 18; 23(4).View Related Profiles. PMID: 29669998.
  6. Nickmanesh R, Stewart RC, Snyder BD, Grinstaff MW, Masri BA, Wilson DR. Contrast-enhanced computed tomography (CECT) attenuation is associated with stiffness of intact knee cartilage. J Orthop Res. 2018 Apr 17. PMID: 29667235.
  7. Bhattarai A, Honkanen JTJ, Myller KAH, Prakash M, Korhonen M, Saukko AEA, Virén T, Joukainen A, Patwa AN, Kröger H, Grinstaff MW, Jurvelin JS, Töyräs J. Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties. Ann Biomed Eng. 2018 Jul; 46(7):1038-1046. PMID: 29654384.
  8. Lu C, Yang D, Sabbatini ME, Colby AH, Grinstaff MW, Oberlies NH, Pearce C, Liu K. Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells. BMC Cancer. 2018 02 06; 18(1):149. PMID: 29409480.
  9. Varongchayakul N, Huttner D, Grinstaff MW, Meller A. Sensing Native Protein Solution Structures Using a Solid-state Nanopore: Unraveling the States of VEGF. Sci Rep. 2018 Jan 17; 8(1):1017. PMID: 29343861.
  10. Nelson BB, Kawcak CE, Barrett MF, McIlwraith CW, Grinstaff MW, Goodrich LR. Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging. Equine Vet J. 2018 Jan 17. PMID: 29344988.
Showing 10 of 268 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 268 publications over 29 distinct years, with a maximum of 26 publications in 2016

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Drug Delivery
Macromolecular Chemistry and Engineering
Tissue Engineering
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