Mark Grinstaff, PhD

Mark W. Grinstaff is a Distinguished Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials and the Director of the Nanotechnology Innovation Center at Boston University.

Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher- Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is an author or co-author on more than 225 peer-reviewed manuscripts, given more than 300 oral presentations, and an inventor or co- inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings.

Mark's current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair. His group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of their current research projects, they are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, they are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, they are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, they are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Mark is a co-founder of several companies that are commercializing his ideas, and he has several products being sold and used in the clinic.

Boston University
Nanotechnology Innovation Center (BUnano)

Boston University College of Engineering
Biomedical Engineering

Boston University School of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

2012 National Academy of Inventors Charter Fellow
2012 Kern Faculty Fellow
2011 Stevenson Biomaterials Lecturer, Syracuse Biomaterials Institute, Syracuse University
2010 Boston University Innovator of the Year
2010 Elected to AIMBE (College of Fellows of the American Institute for Medical & Biomedical Engineering)
2010 Professeur Invité and Certificat sur Honneur, Université de Bordeaux (Bordeaux II)
2009 COE Distinguished Faculty Fellow (5-year Endowed Fellowship)
2008 Edward M. Kennedy Award for Health Care Innovation
2007 Professeurr Invité and Certificat sur Honneur, Université de la Maditerranée (Aix-Marseille II)
2006 Elected Fellow of the American Academy of Nanomedicine
2001 3M Non-Tenured Faculty Award
2001 Johnson and Johnson Focused Giving Grant Recipient
2000 Camille Dreyfus Teacher-Scholar
2000 Alfred P. Sloan Research Fellowship
1999 Pew Scholar in the Biomedical Sciences
1999 NSF Career Award
1998 Whitaker Foundation Grant Recipient
1994 ACS Nobel Laureate Signature Award
1993 NIH Postdoctoral Fellowship
1991 T.S. Piper Award for Outstanding Inorganic Research
1990 The ACS Fellowship of the Colloid & Surface Division (Sponsored by Procter & Gamble)
1989 University of Illinois Chemistry Department Fellowship

Tumor Specific Delivery of Verticillin A Overcomes Epigenetic Silencing Responsible for Drug Resistance
04/01/2018 - 03/31/2023 (PI)
NIH/National Cancer Institute

Prolonged Intranasal Delivery of Ketamine Using Mucoadhesive Particles
06/01/2018 - 05/31/2021 (PI)
Uniformed Services University Health Sciences Henry M Jackson Fdn

Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs)
01/01/2019 - 12/31/2020 (PI)
NIH/National Heart, Lung, and Blood Institute

Basic Research on New Ionic Electrolytes: Characterization
01/01/2016 - 12/31/2020 (PI)

Translational Research in Biomaterials
09/01/2015 - 08/31/2020 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering

Dissolvable Hydrogel dressing for the treatment of burns
02/01/2016 - 12/31/2019 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering

Basic Research on New Ionic Liquid Electrolytes: Synthesis
01/01/2016 - 09/14/2019 (PI)

Glycerol Polycarbonates as New Biomaterials
08/01/2015 - 07/31/2019 (PI)
National Science Foundation

Synthesis, Characterization, and Evaluation of Polymeric Tissue Lubricants
07/08/2014 - 06/30/2019 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Efficacy and safely of a novel, implantable drug-eluting film in sarcoma
01/14/2016 - 11/30/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NIBIB

Showing 10 of 31 results. Show All Results

Yr Title Project-Sub Proj Pubs
2019 Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs) 1R21HL144253-01
2019 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-04 4
2019 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-04 4
2019 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma 5R01EB017722-04 4
2018 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-03 4
2018 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma 5R01EB017722-03 4
2018 Translational Research in Biomaterials 5T32EB006359-09 25
2018 Translational Research in Biomaterials 3T32EB006359-09S1 25
2017 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-02 4
Showing 10 of 64 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Zeng J, Shirihai OS, Grinstaff MW. Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 Jan 30; e1801511.View Related Profiles. PMID: 30698920.
  2. Benizri S, Gissot A, Martin A, Vialet B, Grinstaff MW, Barthélémy P. Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications. Bioconjug Chem. 2019 Jan 29. PMID: 30608140.
  3. Beharaj A, Ekladious I, Grinstaff MW. Poly(Alkyl Glycidate Carbonate)s as Degradable Pressure-Sensitive Adhesives. Angew Chem Int Ed Engl. 2019 Jan 28; 58(5):1407-1411. PMID: 30516857.
  4. El-Elimat T, Raja HA, Ayers S, Kurina SJ, Burdette JE, Mattes Z, Sabatelle R, Bacon JW, Colby AH, Grinstaff MW, Pearce CJ, Oberlies NH. Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression. Org Lett. 2019 Jan 08. PMID: 30620608.
  5. Lu C, Yang D, Klement JD, Oh IK, Savage NM, Waller JL, Colby AH, Grinstaff M, Oberlies NH, Pearce C, Xie Z, Kulp SK, Coss CC, Phelps MA, Albers T, Lebedyeva I, Liu K. SUV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion. Cancer Immunol Res. 2019 Jan 04. PMID: 30610059.
  6. Dourthe B, Nickmanesh R, Wilson DR, D'Agostino P, Patwa AN, Grinstaff MW, Snyder BD, Vereecke E. Assessment of healthy trapeziometacarpal cartilage properties using indentation testing and contrast-enhanced computed tomography. Clin Biomech (Bristol, Avon). 2018 Dec 21; 61:181-189. PMID: 30594765.
  7. Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in ß cells under lipotoxicity. FASEB J. 2018 Dec 14; fj201801292R.View Related Profiles. PMID: 30550357.
  8. Varongchayakul N, Song J, Meller A, Grinstaff MW. Single-molecule protein sensing in a nanopore: a tutorial. Chem Soc Rev. 2018 Nov 26; 47(23):8512-8524. PMID: 30328860.
  9. Wang R, Gilboa T, Song J, Huttner D, Grinstaff MW, Meller A. Single-Molecule Discrimination of Labeled DNAs and Polypeptides Using Photoluminescent-Free TiO2 Nanopores. ACS Nano. 2018 Nov 27; 12(11):11648-11656. PMID: 30372037.
  10. Cooper BG, Chin SL, Xiao R, Buch K, Kim D, Grinstaff MW. Friction-lowering capabilities and human subject preferences for a hydrophilic surface coating on latex substrates: implications for increasing condom usage. R Soc Open Sci. 2018 Oct; 5(10):180291.View Related Profiles. PMID: 30473805.
Showing 10 of 284 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 284 publications over 30 distinct years, with a maximum of 26 publications in 2016

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Drug Delivery
Macromolecular Chemistry and Engineering
Tissue Engineering
Contact for Mentoring:

590 Commonwealth Ave
Boston MA 02215
Google Map

Grinstaff's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department