Mark Grinstaff, PhD

Mark W. Grinstaff is a Distinguished Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials and the Director of the Nanotechnology Innovation Center at Boston University.

Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark's awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher- Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is an author or co-author on more than 225 peer-reviewed manuscripts, given more than 300 oral presentations, and an inventor or co- inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings.

Mark's current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair. His group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of their current research projects, they are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, they are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, they are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, they are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Mark is a co-founder of several companies that are commercializing his ideas, and he has several products being sold and used in the clinic.

Director
Boston University
Nanotechnology Innovation Center (BUnano)


Professor
Boston University College of Engineering
Biomedical Engineering


Professor
Boston University School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine


2012 National Academy of Inventors Charter Fellow
2012 Kern Faculty Fellow
2011 Stevenson Biomaterials Lecturer, Syracuse Biomaterials Institute, Syracuse University
2010 Boston University Innovator of the Year
2010 Elected to AIMBE (College of Fellows of the American Institute for Medical & Biomedical Engineering)
2010 Professeur Invité and Certificat sur Honneur, Université de Bordeaux (Bordeaux II)
2009 COE Distinguished Faculty Fellow (5-year Endowed Fellowship)
2008 Edward M. Kennedy Award for Health Care Innovation
2007 Professeurr Invité and Certificat sur Honneur, Université de la Maditerranée (Aix-Marseille II)
2006 Elected Fellow of the American Academy of Nanomedicine
2001 3M Non-Tenured Faculty Award
2001 Johnson and Johnson Focused Giving Grant Recipient
2000 Camille Dreyfus Teacher-Scholar
2000 Alfred P. Sloan Research Fellowship
1999 Pew Scholar in the Biomedical Sciences
1999 NSF Career Award
1998 Whitaker Foundation Grant Recipient
1994 ACS Nobel Laureate Signature Award
1993 NIH Postdoctoral Fellowship
1991 T.S. Piper Award for Outstanding Inorganic Research
1990 The ACS Fellowship of the Colloid & Surface Division (Sponsored by Procter & Gamble)
1989 University of Illinois Chemistry Department Fellowship


Tumor Specific Delivery of Verticillin A Overcomes Epigenetic Silencing Responsible for Drug Resistance
04/01/2018 - 03/31/2023 (PI)
NIH/National Cancer Institute
1R01CA227433-01

Prolonged Intranasal Delivery of Ketamine Using Mucoadhesive Particles
06/01/2018 - 05/31/2021 (PI)
Uniformed Services University Health Sciences Henry M Jackson Fdn


Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs)
01/01/2019 - 12/31/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
1R21HL144253-01

Basic Research on New Ionic Electrolytes: Characterization
01/01/2016 - 12/31/2020 (PI)
Samsung


Translational Research in Biomaterials
09/01/2015 - 08/31/2020 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5T32EB006359-09S1

Dissolvable Hydrogel dressing for the treatment of burns
02/01/2016 - 12/31/2019 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB021308-04

Basic Research on New Ionic Liquid Electrolytes: Synthesis
01/01/2016 - 09/14/2019 (PI)
Samsung


Glycerol Polycarbonates as New Biomaterials
08/01/2015 - 07/31/2019 (PI)
National Science Foundation
DMR-1507081

Synthesis, Characterization, and Evaluation of Polymeric Tissue Lubricants
07/08/2014 - 06/30/2019 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR066621-04

Efficacy and safely of a novel, implantable drug-eluting film in sarcoma
01/14/2016 - 11/30/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NIBIB
5R01EB017722-03

Showing 10 of 31 results. Show All Results



Yr Title Project-Sub Proj Pubs
2019 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 1R21AG060456-01A1
2019 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 1R21AG063373-01
2019 SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNG TUMOR RECURRENCE 1R01CA232708-01A1
2019 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 1R01CA232056-01A1
2019 Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs) 1R21HL144253-01
2019 TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCE 5R01CA227433-02 4
2019 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-04 4
2019 Dissolvable Hydrogel Dressing for the Treatment of Burns 5R01EB021308-04 4
2019 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma 5R01EB017722-04 6
2018 TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCE 1R01CA227433-01 4
Showing 10 of 69 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E, Boerckel JD. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Sci Transl Med. 2019 Jun 05; 11(495). PMID: 31167930.
     
  2. Blessing WA, Okajima SM, Cubria MB, Villa-Camacho JC, Perez-Viloria M, Williamson PM, Sabogal AN, Suarez S, Ang LH, White S, Flynn E, Rodriguez EK, Grinstaff MW, Nazarian A. Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis. Proc Natl Acad Sci U S A. 2019 Jun 18; 116(25):12183-12192. PMID: 31160441.
     
  3. Stewart RC, Nelson BB, Kawcak CE, Freedman JD, Snyder BD, Goodrich LR, Grinstaff MW. Contrast-Enhanced Computed Tomography Scoring System for Distinguishing Early Osteoarthritis Disease States: A Feasibility Study. J Orthop Res. 2019 May 28.View Related Profiles. PMID: 31136003.
     
  4. Saukko AEA, Turunen MJ, Honkanen MKM, Lovric G, Tiitu V, Honkanen JTJ, Grinstaff MW, Jurvelin JS, Töyräs J. Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging. Sci Rep. 2019 May 08; 9(1):7118. PMID: 31068614.
     
  5. Nelson BB, Mäkelä JTA, Lawson TB, Patwa AN, Barrett MF, McIlwraith CW, Hurtig MB, Snyder BD, Moorman VJ, Grinstaff MW, Goodrich LR, Kawcak CE. Evaluation of equine articular cartilage degeneration after mechanical impact injury using cationic contrast-enhanced computed tomography. Osteoarthritis Cartilage. 2019 May 08. PMID: 31075424.
     
  6. Caputo HE, Straub JE, Grinstaff MW. Design, synthesis, and biomedical applications of synthetic sulphated polysaccharides. Chem Soc Rev. 2019 Apr 15; 48(8):2338-2365.View Related Profiles. PMID: 30742140.
     
  7. Ekladious I, Colson YL, Grinstaff MW. Polymer-drug conjugate therapeutics: advances, insights and prospects. Nat Rev Drug Discov. 2019 Apr; 18(4):273-294. PMID: 30542076.
     
  8. Honkanen MKM, Matikka H, Honkanen JTJ, Bhattarai A, Grinstaff MW, Joukainen A, Kröger H, Jurvelin JS, Töyräs J. Imaging of proteoglycan and water contents in human articular cartilage with full-body CT using dual contrast technique. J Orthop Res. 2019 May; 37(5):1059-1070. PMID: 30816584.
     
  9. Zeng J, Shirihai OS, Grinstaff MW. Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 Jan 30; e1801511.View Related Profiles. PMID: 30698920.
     
  10. Benizri S, Gissot A, Martin A, Vialet B, Grinstaff MW, Barthélémy P. Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications. Bioconjug Chem. 2019 Feb 20; 30(2):366-383. PMID: 30608140.
     
Showing 10 of 293 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 293 publications over 30 distinct years, with a maximum of 26 publications in 2016

YearPublications
19901
19912
19922
19933
19944
19953
19962
19972
19982
19998
20006
20016
20029
20035
20047
20059
200612
20076
200817
200910
201014
201118
201219
201319
201412
201516
201626
201719
201821
201913
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomaterials
Drug Delivery
Macromolecular Chemistry and Engineering
Nanodevices
Self-Assembly
Tissue Engineering
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