Keywords
Last Name

B. Nicolas Bloch, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentRadiology
DivisionBreast Imaging
Address820 Harrison Ave
Boston MA 02118
Phone(617) 414-8172
ORCID ORCID Icon0000-0001-8040-159X
Other Positions
TitleChief
InstitutionBoston Medical Center
DepartmentMR Imaging

TitleCo-Director
InstitutionBoston University School of Medicine
DepartmentMS Bioimaging Program

TitleProgram Director
InstitutionBoston University School of Medicine
DepartmentBreast Imaging Fellowship

 Awards and Honors

Start-EndDescription
2001National Bank Austria: Austrian National Bank Research Award
2008SCBT/MR: Cum Laude Research Award
2011Coulter Foundation: Wallace H. Coulter Translational Research Partnership Award
2012Coulter Foundation: Wallace H. Coulter Translational Research Partnership Award
2015Boston University: Jorge Soto Researcher of the Year Award - Radiology
 Research Expertise & Professional Interests
As a radiologist in an academic medical center, I am devoted to improving clinical care for my patients suffering from breast and prostate cancer. My research has focused on developing new imaging protocols and on correlating prostate and breast cancer imaging phenotypes and MR/US imaging classifiers with histology, immunohistochemistry, and gene expression profiles. I recognize the imperative need for correlating imaging phenotypes with tumor genotypes in order to advance knowledge regarding a broad range of breast and prostate diseases, as well as their early diagnosis, progression/behavior and treatment, by developing new (imaging) biomarkers.
A second major research focus is the design and development of biopsy and treatment tools, like biopsy markers (biopsy clips; Coulter award 2011), and treatment planning phantoms and atlases in collaboration with engineers and image post-processors.

 Self-Described Keywords
  • Prostate Cancer, Breast Cancer, Imaging Phenotypes, Cancer Genotypes, MRI, Ultrasound, biopsy marker, treatment planning phantoms, Image guided interventions, CAD analysis,
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Xiang HF, Lu HM, Efstathiou JA, Zietman AL, Armas R, Harris K, Bloch BN, Qureshi MM, Keohan S, Hirsch AE. Dosimetric impacts of endorectal balloon in CyberKnife stereotactic body radiation therapy (SBRT) for early-stage prostate cancer. J Appl Clin Med Phys. 2017 Apr 13. PMID: 28407345.
    View in: PubMed
  2. Wan T, Bloch BN, Plecha D, Thompson CL, Gilmore H, Jaffe C, Harris L, Madabhushi A. A Radio-genomics Approach for Identifying High Risk Estrogen Receptor-positive Breast Cancers on DCE-MRI: Preliminary Results in Predicting OncotypeDX Risk Scores. Sci Rep. 2016 Feb 18; 6:21394. PMID: 26887643.
    View in: PubMed
  3. Kaplan JA, Grinstaff MW, Bloch BN. Polymer film-nanoparticle composites as new multimodality, non-migrating breast biopsy markers. Eur Radiol. 2016 Mar; 26(3):866-73. PMID: 26060064.
    View in: PubMed
  4. Bloch BN, Kuligowska E. Future role of ultrasound and MR imaging in prostate cancer: Editorial Comment on: T. Szopinski, A. Nowicki, F. Zatura, T. Golabek and P. Chlosta Novel trends in transrectal ultrasound imaging of prostate gland carcinoma. J Ultrason. 2015 Mar; 15(60):102-4. PMID: 26672493.
    View in: PubMed
  5. Sparks R, Bloch BN, Feleppa E, Barratt D, Moses D, Ponsky L, Madabhushi A. Multiattribute probabilistic prostate elastic registration (MAPPER): application to fusion of ultrasound and magnetic resonance imaging. Med Phys. 2015 Mar; 42(3):1153-63. PMID: 25735270.
    View in: PubMed
  6. Buch KA, Qureshi MM, Carpentier B, Cunningham DA, Stone M, Jaffe C, Quinn M, Gonzalez C, LaVoye J, Hines N, Bloch BN. Surveillance of probably benign (BI-RADS 3) lesions in mammography: what is the right follow-up protocol? Breast J. 2015 Mar-Apr; 21(2):168-74. PMID: 25669425.
    View in: PubMed
  7. Wan T, Bloch BN, Danish S, Madabhushi A. A Learning Based Fiducial-driven Registration Scheme for Evaluating Laser Ablation Changes in Neurological Disorders. Neurocomputing. 2014 Nov 20; 144:24-37. PMID: 25225455.
    View in: PubMed
  8. Buch K, Morancy T, Kaplan I, Qureshi MM, Hirsch AE, Rofksy NM, Holupka E, Oismueller R, Hawliczek R, Helbich TH, Bloch BN. Improved dosimetry in prostate brachytherapy using high resolution contrast enhanced magnetic resonance imaging: a feasibility study. J Contemp Brachytherapy. 2015 Jan; 6(4):337-43. PMID: 25834576.
    View in: PubMed
  9. Rusu M, Bloch BN, Jaffe CC, Genega EM, Lenkinski RE, Rofsky NM, Feleppa E, Madabhushi A. Prostatome: a combined anatomical and disease based MRI atlas of the prostate. Med Phys. 2014 Jul; 41(7):072301. PMID: 24989400.
    View in: PubMed
  10. Ginsburg SB, Viswanath SE, Bloch BN, Rofsky NM, Genega EM, Lenkinski RE, Madabhushi A. Novel PCA-VIP scheme for ranking MRI protocols and identifying computer-extracted MRI measurements associated with central gland and peripheral zone prostate tumors. J Magn Reson Imaging. 2015 May; 41(5):1383-93. PMID: 24943647.
    View in: PubMed
  11. Costa DN, Bloch BN, Yao DF, Sanda MG, Ngo L, Genega EM, Pedrosa I, DeWolf WC, Rofsky NM. Diagnosis of relevant prostate cancer using supplementary cores from magnetic resonance imaging-prompted areas following multiple failed biopsies. Magn Reson Imaging. 2013 Jul; 31(6):947-52. PMID: 23602725.
    View in: PubMed
  12. Bubley GJ, Bloch BN, Vazquez C, Genega E, Holupka E, Rofsky N, Kaplan I. Accuracy of endorectal magnetic resonance/transrectal ultrasound fusion for detection of prostate cancer during brachytherapy. Urology. 2013 Jun; 81(6):1284-9. PMID: 23490527.
    View in: PubMed
  13. Rusu M, Bloch BN, Jaffe CC, Rofsky NM, Genega EM, Feleppa E, Lenkinski RE, Madabhushi A. Statistical 3D Prostate Imaging Atlas Construction via Anatomically Constrained Registration. Proc SPIE Int Soc Opt Eng. 2013 Mar 13; 8669. PMID: 24392203.
    View in: PubMed
  14. Sparks R, Bloch BN, Feleppa E, Barratt D, Madabhushi A. Fully Automated Prostate Magnetic Resonance Imaging and Transrectal Ultrasound Fusion via a Probabilistic Registration Metric. Proc SPIE Int Soc Opt Eng. 2013 Mar 08; 8671. PMID: 24353393.
    View in: PubMed
  15. Rusu M, Bloch BN, Jaffe C, Rofsky N, Genega E, Lenkinski R, Madabhushi A. . Statistical 3D Prostate Imaging Atlas Construction via Anatomically Constrained Registration. SPIE Medical Imaging. 2013; 866913-9.
  16. Sparks R, Feleppa E, Barratt D, Bloch BN, Madabhushi A. Fully Automated Prostate MRI and Transrectal Ultrasound(TRUS) Fusion via a Probabilistic Registration Metric. SPIE Medical Imaging. 2013; (March 8): doi: 10.1117/12.2007610..
  17. Ginsburg SB, Bloch BN, Rofsky NM, Genega E, Lenkinski RN, Madabhushi A. Iterative Multiple Reference Tissue Method for Estimating Pharmacokinetic Parameters on Prostate DCE MRI. SPIE Medical Imaging. 2013; 86701J-13.
  18. Wan T, Bloch BN, Danish S, Madabhushi A. A Novel Point-based Nonrigid Image Registration Scheme Based on Learning Optimal Landmark Configurations. SPIE Medical Imaging. 2013; 866934-12; doi: 10.1117/12.200.
  19. Bloch BN, Genega EM, Costa DN, Pedrosa I, Smith MP, Kressel HY, Ngo L, Sanda MG, Dewolf WC, Rofsky NM. Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI. Eur Radiol. 2012 Oct; 22(10):2201-10. PMID: 22661019.
    View in: PubMed
  20. Viswanath SE, Bloch NB, Chappelow JC, Toth R, Rofsky NM, Genega EM, Lenkinski RE, Madabhushi A. Central gland and peripheral zone prostate tumors have significantly different quantitative imaging signatures on 3 Tesla endorectal, in vivo T2-weighted MR imagery. J Magn Reson Imaging. 2012 Jul; 36(1):213-24. PMID: 22337003.
    View in: PubMed
  21. Bulman JC, Toth R, Patel AD, Bloch BN, McMahon CJ, Ngo L, Madabhushi A, Rofsky NM. Automated computer-derived prostate volumes from MR imaging data: comparison with radiologist-derived MR imaging and pathologic specimen volumes. Radiology. 2012 Jan; 262(1):144-51. PMID: 22190657.
    View in: PubMed
  22. Toth R, Bloch BN, Genega EM, Rofsky NM, Lenkinski RE, Rosen MA, Kalyanpur A, Pungavkar S, Madabhushi A. Accurate prostate volume estimation using multifeature active shape models on T2-weighted MRI. Acad Radiol. 2011 Jun; 18(6):745-54. PMID: 21549962.
    View in: PubMed
  23. Chappelow J, Bloch BN, Rofsky N, Genega E, Lenkinski R, DeWolf W, Madabhushi A. Elastic registration of multimodal prostate MRI and histology via multiattribute combined mutual information. Med Phys. 2011 Apr; 38(4):2005-18. PMID: 21626933.
    View in: PubMed
  24. Viswanath S, Bloch BN, Chappelow J, Patel P, Rofsky N, Lenkinski R, Genega E, Madabhushi A. Enhanced Multi-Protocol Analysis via Intelligent Supervised Embedding (EMPrAvISE): Detecting Prostate Cancer on Multi-Parametric MRI. Proc SPIE Int Soc Opt Eng. 2011 Mar 04; 7963:79630U. PMID: 25301991.
    View in: PubMed
  25. Xiao G, Bloch BN, Chappelow J, Genega EM, Rofsky NM, Lenkinski RE, Tomaszewski J, Feldman MD, Rosen M, Madabhushi A. Determining histology-MRI slice correspondences for defining MRI-based disease signatures of prostate cancer. Comput Med Imaging Graph. 2011 Oct-Dec; 35(7-8):568-78. PMID: 21255974.
    View in: PubMed
  26. Toth, R, Bulman, J, Patel, A, Bloch, BN, Genega, E, Rofsky, N, Lenkinski, R, Madabhushi, A. Integrating an Adaptive Region Based Appearance Model with a Landmark Free Statistical Shape Model: Application to Prostate MRI Segmentation. SPIE Medical Imaging. 2011; 7962.
  27. Viswanath, S, Palumbo, D, Chappelow, J, Patel, P, A, Bloch, BN, Genega, E, Rofsky, N, Lenkinski, R, Madabhushi, A, . Empirical evaluation of bias field correction algorithms for computer-aided detection of prostate cancer on T2w MRI. SPIE Medical Imaging. 2011; 7963.
  28. Viswanath, S, Chappelow, J, Patel, P, A, Bloch, BN, Genega, E, Rofsky, N, Lenkinski, R, Madabhushi, A. Enhanced multiprotocol analysis via intelligent supervised embedding (EMPrAvISE) for prostate cancer detection on MRI. SPIE Medical Imaging. 2011; 7962.
  29. Keeling AN, Morrin MM, McKenzie C, Farrell RJ, Sheth SG, Ngo L, Bloch BN, Pedrosa I, Rofsky NM. Intravenous, contrast-enhanced MR colonography using air as endoluminal contrast agent: impact on colorectal polyp detection. Eur J Radiol. 2012 Jan; 81(1):31-8. PMID: 21131152.
    View in: PubMed
  30. Eyal E, Bloch BN, Rofsky NM, Furman-Haran E, Genega EM, Lenkinski RE, Degani H. Principal component analysis of dynamic contrast enhanced MRI in human prostate cancer. Invest Radiol. 2010 Apr; 45(4):174-81. PMID: 20177391.
    View in: PubMed
  31. G Xiao, BN Bloch, J Chappelow, E Genega, N Rofsky, R Lenkinski, A Madabhushi. A structural-functional MRI-based disease atlas: application to computer-aided-diagnosis of prostate cancer. SPIE Medical Imaging. 2010; (762303-12):doi: 10.1117/12.845554.
  32. McMahon CJ, Bloch BN, Lenkinski RE, Rofsky NM. Dynamic contrast-enhanced MR imaging in the evaluation of patients with prostate cancer. Magn Reson Imaging Clin N Am. 2009 May; 17(2):363-83. PMID: 19406364.
    View in: PubMed
  33. Viswanath S, Bloch BN, Rosen M, Chappelow J, Toth R, Rofsky N, Lenkinski R, Genega E, Kalyanpur A, Madabhushi A. Integrating Structural and Functional Imaging for Computer Assisted Detection of Prostate Cancer on Multi-Protocol In Vivo 3 Tesla MRI. Proc SPIE Int Soc Opt Eng. 2009 Feb 27; 7260:72603I. PMID: 25301989.
    View in: PubMed
  34. Viswanath S, Bloch BN, Rosen M, Chappelow J, Toth, R, Rofsky N, Lenkinski R, Genega E, Kalyanpur A, Madabhushi A, . Integrating Structural and Functional Imaging for Computer Assisted Detection of Prostate Cancer on Multi-Protocol in vivo 3 Tesla MRI. SPIE Medical Imaging. 2009; 7260.
  35. Chappelow, J, Bloch, BN, Rofsky, N, Genega, E, Lenkinski, R, DeWolf, W, Viswanath, S, Madabhushi, A. COLLINARUS: Collection of Image-derived Non-linear Attributes for Registration Using Splines. SPIE Medical Imaging. 2009; 7259.
  36. Morrin MM, Pedrosa I, McKenzie CA, Farrell RJ, Bloch N, Solazzo S, Ngo L, Goldberg SN, Rofsky NM. Parallel imaging enhanced MR colonography using a phantom model. J Magn Reson Imaging. 2008 Sep; 28(3):664-72. PMID: 18777549.
    View in: PubMed
  37. Lenkinski RE, Bloch BN, Liu F, Frangioni JV, Perner S, Rubin MA, Genega EM, Rofsky NM, Gaston SM. An illustration of the potential for mapping MRI/MRS parameters with genetic over-expression profiles in human prostate cancer. MAGMA. 2008 Nov; 21(6):411-21. PMID: 18752015.
    View in: PubMed
  38. Bloch BN, Lenkinski RE, Rofsky NM. The role of magnetic resonance imaging (MRI) in prostate cancer imaging and staging at 1.5 and 3 Tesla: the Beth Israel Deaconess Medical Center (BIDMC) approach. Cancer Biomark. 2008; 4(4-5):251-62. PMID: 18957714.
    View in: PubMed
  39. Viswanath S, Bloch BN, Genega E, Rofsky N, Lenkinski R, Chappelow J, Toth R, Madabhushi A. A comprehensive segmentation, registration, and cancer detection scheme on 3 Tesla in vivo prostate DCE-MRI. Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):662-9. PMID: 18979803.
    View in: PubMed
  40. Bloch BN, Furman-Haran E, Helbich TH, Lenkinski RE, Degani H, Kratzik C, Susani M, Haitel A, Jaromi S, Ngo L, Rofsky NM. Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results. Radiology. 2007 Oct; 245(1):176-85. PMID: 17717328.
    View in: PubMed
  41. Bloch BN, Lenkinski RE, Helbich TH, Ngo L, Oismueller R, Jaromi S, Kubin K, Hawliczek R, Kaplan ID, Rofsky NM. Prostate postbrachytherapy seed distribution: comparison of high-resolution, contrast-enhanced, T1- and T2-weighted endorectal magnetic resonance imaging versus computed tomography: initial experience. Int J Radiat Oncol Biol Phys. 2007 Sep 1; 69(1):70-8. PMID: 17513062.
    View in: PubMed
  42. Rosen Y, Bloch BN, Lenkinski RE, Greenman RL, Marquis RP, Rofsky NM. 3T MR of the prostate: reducing susceptibility gradients by inflating the endorectal coil with a barium sulfate suspension. Magn Reson Med. 2007 May; 57(5):898-904. PMID: 17457870.
    View in: PubMed
  43. Gaston SM, Soares MA, Siddiqui MM, Vu D, Lee JM, Goldner DL, Brice MJ, Shih JC, Upton MP, Perides G, Baptista J, Lavin PT, Bloch BN, Genega EM, Rubin MA, Lenkinski RE. Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: mapping tumor invasion of the prostate capsule. Nat Med. 2005 Jan; 11(1):95-101. PMID: 15619629.
    View in: PubMed
  44. Bloch BN, Rofsky NM, Baroni RH, Marquis RP, Pedrosa I, Lenkinski RE. 3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1). Acad Radiol. 2004 Aug; 11(8):863-7. PMID: 15288036.
    View in: PubMed
  45. Bloch BN, Helbich T, Heinz-Peer G. [Prostatic carcinoma: current status of diagnostic imaging]. Wien Med Wochenschr Suppl. 2002; (113):89-91. PMID: 12621851.
    View in: PubMed
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