Jean M. Francis, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Nephrology

MD, Lebanese University




Research Interests:

1- Thrombotic microangiopathy (TMA) is a rare but very serious condition. It is characterized by widespread microthrombi formation in multiple organs (in its severe and disseminated form) or localized microthrombi in the kidney (in its limited form). TMA is usually characterized by thrombocytopenia, microangiopathic hemolytic anemia (MAHA), and multiple organ injury and dysfunction.

Early detection and accurate diagnosis are essential to implement appropriate therapies, and improve patients’ prognosis and survival. Delay in diagnosis could result in late implementation of appropriate therapies, and this could result in permanent and irreversible organ damage. Left untreated TMA is associated with very high level of morbidity and mortality. TMA presentation could be highly variable making the diagnosis even more difficult. Once the diagnosis of TMA is established, defining the underlying cause is even more challenging due to frequent overlap between the common causes of TMA.

We have a unique multidisciplinary approach to the management of this very rare disease. A TMA team was established at Boston University Medical Center with the primary objective of improving patients care and outcome. Our Team works in close collaboration with the ARC on Thrombosis.

A primary goal of the team is to provide excellent patient care. The TMA team is multidisciplinary involving: nephrologists, hematologists, the director of apheresis, pediatric hematologist and pharmacist. They are always available to manage any patient with suspected TMA. Special protocols and algorithm have been created by the team to help guiding the provider in making an accurate diagnosis of any TMA case.

Another goal of the TMA team is educational. We are actively spreading awareness of this rare disease between our providers at BMC, and also regionally and nationally by organizing lectures and seminars as well as mini-symposia.

A third goal of the TMA team is to advance basic and clinical research related to TMA. We are active in clinical trials addressing the efficacy of newer agents for the treatment of complement mediated HUS a special form of TMA. Our scientists are also trying to understand some underlying pathological mechanisms that could be contributing to TMA.

2- As the Medical Director of the Kidney Transplant program at BUSM and BMC, I am involved in all aspect of care related to kidney transplantation. We evaluate kidney transplant recipients and donors, and manage all the care of post transplant patients. My interests include, BK virus infection, Antibody Mediated Rejection, recurrent GN after kidney transplantation, and metabolic disorders after kidney transplantation.

3- I am the Medical Director of the combined Pancreas Transplant Program between BUMC and BWH. This is a combined program between the two institutions that facilitate the cure of type 1 & 2 DM with pancreas transplantation in very selected patients.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research



2018-2019 Boston University School of Medicine: Faculty Induction into Alpha Omega Alpha Society
2016-2017 Boston University School of Medicine: Excellence In Teaching Award, Hospital Based Faculty
2016-2017 Boston University School of Medicine : Nominated for Clinical Innovation Award
2015-2016 Boston University School of Medicine: Excellence In Teaching Award, Hospital Based Faculty
2014-2015 Boston University School of Medicine: Excellence in Teaching Award, Subspeciality Faculty



Atypic Hemolytic Uremic Syndrome (aHUS)
03/17/2017 - 03/17/2019 (PI)
Alexion Pharmaceuticals


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Cohen-Bucay A, Francis JM, Gordon CE. Progress in hepatitis C virus management in chronic kidney disease. Curr Opin Nephrol Hypertens. 2021 09 01; 30(5):493-500. PMID: 34054074
     
  2. Lerner GB, Virmani S, Henderson JM, Francis JM, Beck LH. A conceptual framework linking immunology, pathology, and clinical features in primary membranous nephropathy. Kidney Int. 2021 08; 100(2):289-300.View Related Profiles. PMID: 33857571
     
  3. Levin SR, Farber A, Eslami MH, Tan TW, Osborne NH, Francis JM, Ghai S, Siracuse JJ. Association of Medicaid Expansion with Tunneled Dialysis Catheter Use at the Time of First Arteriovenous Access Creation. Ann Vasc Surg. 2021 Jul; 74:11-20.View Related Profiles. PMID: 33508455
     
  4. Kamel MH, Yin W, Zavaro C, Francis JM, Chitalia VC. Hyperthrombotic Milieu in COVID-19 Patients. Cells. 2020 10 31; 9(11).View Related Profiles. PMID: 33142844; PMCID: PMC7694011; DOI: 10.3390/cells9112392;
     
  5. Cohen-Bucay A, Ramirez-Andrade SE, Gordon CE, Francis JM, Chitalia VC. Advances in BK Virus Complications in Organ Transplantation and Beyond. Kidney Med. 2020 Nov-Dec; 2(6):771-786.View Related Profiles. PMID: 33319201; PMCID: PMC7729234; DOI: 10.1016/j.xkme.2020.06.015;
     
  6. Driscoll D, Bleecker G, Francis J, Jaberi A. Acute Hemodialysis for Treatment of Severe Ethanol Intoxication. Kidney Med. 2020 Nov-Dec; 2(6):793-796.View Related Profiles. PMID: 33319202; PMCID: PMC7729238; DOI: 10.1016/j.xkme.2020.06.012;
     
  7. Angel-Korman A, Stern L, Angel Y, Sarosiek S, Menn-Josephy H, Francis J, Ghai S, Sloan JM, Sanchorawala V, Havasi A. The Role of Kidney Transplantation in Monoclonal Ig Deposition Disease. Kidney Int Rep. 2020 Apr; 5(4):485-493.View Related Profiles. PMID: 32274452; PMCID: PMC7136323; DOI: 10.1016/j.ekir.2020.01.011;
     
  8. Addo-Tabiri NO, Chudasama R, Vasudeva R, Leiva O, Garcia B, Ravid JD, Bunze T, Rosen L, Belghasem M, Francis J, Brophy M, Johnson B, Ferguson R, Weinberg J, Chitalia VC. Black Patients Experience Highest Rates of Cancer-associated Venous Thromboembolism. Am J Clin Oncol. 2020 02; 43(2):94-100.View Related Profiles. PMID: 31809329
     
  9. Lyle C, Richards S, Yasuda K, Napoleon MA, Walker J, Arinze N, Belghasem M, Vellard I, Yin W, Ravid JD, Zavaro E, Amraei R, Francis J, Phatak U, Rifkin IR, Rahimi N, Chitalia VC. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Sci Rep. 2019 12 27; 9(1):20257.View Related Profiles. PMID: 31882749; PMCID: PMC6934810; DOI: 10.1038/s41598-019-56208-1;
     
  10. Belghasem M, Roth D, Richards S, Napolene MA, Walker J, Yin W, Arinze N, Lyle C, Spencer C, Francis JM, Thompson C, Andry C, Whelan SA, Lee N, Ravid K, Chitalia VC. Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor-tissue factor axis. Blood. 2019 12 26; 134(26):2399-2413.View Related Profiles. PMID: 31877217; PMCID: PMC6933294; DOI: 10.1182/blood.2019001675;
     
Showing 10 of 55 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 55 publications over 16 distinct years, with a maximum of 9 publications in 2019

YearPublications
20041
20072
20082
20091
20101
20112
20123
20131
20143
20154
20166
20174
20188
20199
20205
20213

Available to Mentor as: (Review Mentor Role Definitions):
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  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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