Robert A. Stern, PhD
Professor
Boston University School of Medicine
Dept of Neurology

PhD, University of Rhode Island
MA, University of Rhode Island



As the Clinical Core Director of the NIA-funded Boston University Alzheimer’s Disease Center (BU ADC), I oversee a multidisciplinary group of talented scientists and clinicians and direct the center’s longitudinal research registry, as well as several NIH- and industry-funded diagnostic, prevention, and treatment trials. The major focus of my current research is on the long-term effects of repetitive head impacts in athletes, including the neuropathological, risk factors (genetic and head impact exposure), neuroimaging, biomarker development, and clinical diagnosis and descriptions of the neurodegenerative disease, chronic traumatic encephalopathy (CTE). Recently, my study in Nature’s Translational Psychiatry found an association between participation in youth tackle football before age 12 and impaired mood and behavior later in life.

Other areas of my current and recent research program include the diagnosis, risk factors, and treatment of cognitive decline and neuropsychiatric dysfunction in aging. I have also published extensively on the psychometric properties of many widely used tests in neuropsychology, as well as the use of various instruments and biomarkers in the differential diagnosis of neurodegenerative disease. In addition, I have developed several commonly used tests and instruments, including the Neuropsychological Assessment Battery (NAB). I have had leadership positions in several training programs, have mentored over 40 trainees, and play a key role in the professional development of junior faculty in the BU School of Medicine (BUSM) Neurology Department.

Professor
Boston University School of Medicine
Anatomy & Neurobiology


Professor
Boston University School of Medicine
Neurosurgery


Director of Clinical Research
Boston University School of Medicine
Chronic Traumatic Encephalopathy Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Active Staff Privileges
Boston Medical Center
Neurology




Protocol #CNP520A2202J, A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of CNP520 in participants at risk for the onset of clinical symptoms of
05/01/2018 - 04/30/2025 (PI)
Novartis Pharmaceuticals Corporation

Protocol #API015A2201J, A randomized, double-blind, placebo-controlled, two cohort parallel group study to evaluate the efficacy of CAD106 and CNP520 in participants at risk for the onset of clinical
02/01/2018 - 08/31/2024 (PI)
Novartis Pharmaceuticals Corporation

Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors
12/15/2015 - 11/30/2022 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5U01NS093334-03

Registry of Amyloid Positive Patients for Alzheimer's Disease Drug Research Trials ("RAmP" or 18F-AV-45-A25)
03/20/2017 - 03/19/2020 (PI)
Avid Radiopharmaceuticals, Inc.


Tau PET Imaging for the USC Alzheimer's Therapeutic Research Institute (USC ATRI) A4 Trial (“A4 TAU”)
10/01/2016 - 12/31/2018 (PI)
University of Southern California Fundation for NIH


A placebo-controlled, double-blind, parallel-group, bayesian adaptive randomization design and dose regimen-finding study to evaluate the safety tolerability and efficacy of BAN2401 in subjects with
02/01/2013 - 12/31/2018 (PI)
Eisai, Inc


Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study)
12/11/2015 - 12/10/2018 (PI)
University of Southern California Eli Lilly and Co


Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study
11/01/2015 - 10/31/2018 (PI)
University of Southern California Alzheimer's Assoc


An Open label, multicenter study evaluating the imaging characteristics of a follow up F-AV-1451 scan in subjects that participated in the confirmatory cohort of FV-AV-1451-A05
09/29/2016 - 09/28/2018 (PI)
Avid Radiopharmaceuticals, Inc.


Measuring Glial metabolism in repetitive brain trauma and Alzheimer's Disease
08/15/2015 - 08/14/2018 (PI)
The Brigham and Women's Hospital, Inc. DOD Army Med Resrch


Showing 10 of 42 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors 5U01NS093334-03 1
2017 Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors 5U01NS093334-02 1
2017 Core B: Clinical Core 2P30AG013846-21-6895 428
2016 Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk Factors 1U01NS093334-01 1
2013 Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers 5R01NS078337-03 19
2013 OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINE 5R01CA129769-05 28
2012 Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers 5R01NS078337-02 19
2012 OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINE 5R01CA129769-04 28
2012 Subclinical Hypothyroidism: Mood, Cognition and the effect of L-thyroxine treatme 5R01MH080295-05 24
2011 Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers 1R01NS078337-01A1 19
Showing 10 of 23 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Jul 25.View Related Profiles. PMID: 30053297.
     
  2. Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Jul 23.View Related Profiles. PMID: 30049650.
     
  3. Ropacki MT, Hannesdottir K, Hendrix S, Gordon MF, Stephenson D, Coons SJ, Stern RA. Response to "Use of Qualitative Data to Support Content Validity of Performance-Based Cognitive Outcome Assessments". Ther Innov Regul Sci. 2018 Jul; 52(4):405-406. PMID: 29996731.
     
  4. Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, et al. AnalysiView Related Profiles. PMID: 29930110.
     
  5. Gill J, Mustapic M, Diaz-Arrastia R, Lange R, Gulyani S, Diehl T, Motamedi V, Osier N, Stern RA, Kapogiannis D. Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel. Brain Inj. 2018 Jun 18; 1-8. PMID: 29913077.
     
  6. Lepage C, Muehlmann M, Tripodis Y, Hufschmidt J, Stamm J, Green K, Wrobel P, Schultz V, Weir I, Alosco ML, Baugh CM, Fritts NG, Martin BM, Chaisson C, Coleman MJ, Lin AP, Pasternak O, Makris N, Stern RA, Shenton ME, Koerte IK. Limbic system structure volumes and associated neurocognitive functioning in former NFL players. Brain Imaging Behav. 2018 May 19.View Related Profiles. PMID: 29779184; DOI: 10.1007/s11682-018-9895-z;.
     
  7. Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901.View Related Profiles. PMID: 29710395.
     
  8. Guenette JP, Stern RA, Tripodis Y, Chua AS, Schultz V, Sydnor VJ, Somes N, Karmacharya S, Lepage C, Wrobel P, Alosco ML, Martin BM, Chaisson CE, Coleman MJ, Lin AP, Pasternak O, Makris N, Shenton ME, Koerte IK. Automated versus manual segmentation of brain region volumes in former football players. Neuroimage Clin. 2018; 18:888-896.View Related Profiles. PMID: 29876273.
     
  9. Clapp JD, Luta G, Small BJ, Ahles TA, Root JC, Graham D, Hurria A, Jacobsen PB, Jim H, McDonald BC, Stern RA, Saykin AJ, Mandelblatt JS. The Impact of Using Different Reference Populations on Measurement of Breast Cancer-Related Cognitive Impairment Rates. Arch Clin Neuropsychol. 2018 Feb 17. PMID: 29471454.
     
  10. Tao Q, Zhu H, Chen X, Stern RA, Kowall N, Au R, Blusztajn JK, Qiu WQ. Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer's Disease. J Alzheimers Dis. 2018; 62(2):597-609.View Related Profiles. PMID: 29480193.
     
Showing 10 of 166 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 166 publications over 32 distinct years, with a maximum of 14 publications in 2015 and 2016

YearPublications
19861
19871
19891
19901
19914
19926
19936
19943
19955
19966
19974
19981
19993
20005
20011
20022
20036
20042
20051
20062
20074
20085
20094
20105
20117
201210
20136
201412
201514
201614
201712
201812
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Alzheimer's Disease
Chronic Traumatic Encephalopathy
Concussion
Dementia
Neuropsychology
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