Louis C. Gerstenfeld, PhD
Boston University School of Medicine
Dept of Orthopaedic Surgery

PhD, Boston University School of Medicine

My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous preclinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA review panels for skeletal tissue biology and the DOD review panels for orthopedic related research.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Research Professor
Boston University School of Medicine

A Systems Genetic Approach to Fracture Healing
08/01/2016 - 07/31/2018 (PI)
NIH/National Institute of Arthritis & Mu

An Evaluation of Serum Based Indices to Assess Fracture Healing
09/15/2015 - 07/31/2018 (PI)
NIH/National Institute of Arthritis & Mu

The mechanistic role of subchondral bone cysts and bone marrow lesions as markers of cases for hip arthroplasty
07/01/2017 - 06/30/2018 (Co-PI)
Orthopaedic Research and Education Found

Role of Angiogenesis in Distraction Osteogenesis
09/01/2011 - 08/31/2017 (PI)
NIH/National Institute of Arthritis & Mu

Tracking Cell Fate During Mechanically Directed Bone Regeneration In Vivo
06/01/2013 - 05/31/2017 (Co-PI)
PI: Elise F. Morgan, PhD
National Science Foundation

A Systems Genetics Approach to Fracture Healing
08/03/2012 - 07/31/2016 (PI)
NIH/National Institute of Arthritis & Mu

Role of Angiogenesis in Bone Repair
01/01/2012 - 12/31/2014 (PI)
Musculoskeletal Transplant Foundation

Comparison of a Soluble TGF-Beta Receptor Family Protein on Murine Fracture Healing
02/01/2011 - 01/31/2013 (PI)
Acceleron Pharma, Inc

Molecular Mechanisms of Skeletal Repair
06/15/2004 - 05/31/2009 (Co-PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5 P01 AR49920 05

In Vivo Imaging Analysis System-Xenogen IVIS Spectrum
04/17/2008 - 04/16/2009 (PI)
NIH/National Center for Health Research Resources
1 S10 RR24523 01

Showing 10 of 33 results. Show All Results

Yr Title Project-Sub Proj Pubs
2016 An Evaluation of Serum Based Indices to Assess Fracture Healing 5R21AR067900-02
2016 A Systems Genetics Approach to Fracture Healing 4R01AR059741-05
2015 An Evaluation of Serum Based Indices to Assess Fracture Healing 1R21AR067900-01A1
2015 A Systems Genetics Approach to Fracture Healing 5R01AR059741-04
2015 Role of Angiogenesis in Distraction Osteogenesis 5R01AR056637-05 5
2014 A Systems Genetics Approach to Fracture Healing 5R01AR059741-03
2014 Role of Angiogenesis in Distraction Osteogenesis 5R01AR056637-04 5
2013 A Systems Genetics Approach to Fracture Healing 5R01AR059741-02
2013 Role of Angiogenesis in Distraction Osteogenesis 5R01AR056637-03 5
2012 A Systems Genetics Approach to Fracture Healing 1R01AR059741-01A1
Showing 10 of 35 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol. 2018 Jan 30.View Related Profiles. PMID: 29380368.
  2. Hussein AI, Mancini C, Lybrand KE, Cooke ME, Matheny HE, Hogue BL, Tornetta P, Gerstenfeld LC. Serum proteomic assessment of the progression of fracture healing. J Orthop Res. 2017 Oct 02.View Related Profiles. PMID: 28971515.
  3. Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC, Luo Z. AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation. Biochim Biophys Acta. 2017 12; 1864(12):2369-2377.View Related Profiles. PMID: 28847510.
  4. Cooke ME, Hussein AI, Lybrand KE, Wulff A, Simmons E, Choi JH, Litrenta J, Ricci WM, Nascone JW, O''Toole RV, Morgan EF, Gerstenfeld LC, Tornetta P. Correlation between RUST assessments of fracture healing to structural and biomechanical properties. J Orthop Res. 2017 Aug 22.View Related Profiles. PMID: 28833572.
  5. Alshenibr W, Tashkandi MM, Alsaqer SF, Alkheriji Y, Wise A, Fulzele S, Mehra P, Goldring MB, Gerstenfeld LC, Bais MV. Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis. Arthritis Res Ther. 2017 Aug 02; 19(1):179.View Related Profiles. PMID: 28764769.
  6. Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development. Toxicol Sci. 2017 Jul 01; 158(1):63-75.View Related Profiles. PMID: 28398592; DOI: 10.1093/toxsci/kfx067;.
  7. Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61.View Related Profiles. PMID: 28412469; DOI: 10.1016/j.bone.2017.04.002;.
  8. Lim JC, Ko KI, Mattos M, Fang M, Zhang C, Feinberg D, Sindi H, Li S, Alblowi J, Kayal RA, Einhorn TA, Gerstenfeld LC, Graves DT. TNFa contributes to diabetes impaired angiogenesis in fracture healing. Bone. 2017 Jun; 99:26-38. PMID: 28285015; DOI: 10.1016/j.bone.2017.02.014;.
  9. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214.View Related Profiles. PMID: 27324177; DOI: 10.1002/jbmr.2891;.
  10. Morgan EF, Pittman J, DeGiacomo A, Cusher D, de Bakker CM, Mroszczyk KA, Grinstaff MW, Gerstenfeld LC. BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing. J Orthop Res. 2016 Dec; 34(12):2096-2105.View Related Profiles. PMID: 26990682; DOI: 10.1002/jor.23233;.
Showing 10 of 193 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 193 publications over 37 distinct years, with a maximum of 14 publications in 2003

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bone Histomorphometry
Cell Biology of Skeletal Tissues
Extracellular Matrix
Fracture Healing

Over the last 30 years Dr. Gerstenfeld has participated in mentoring a wide variety of students from high school students to medical resident trainees. At the post graduate level he was the primary thesis adviser to one PhD student 3 MD/PhD students, 11 DMSc students and 52 master’s students. He has mentored 19 post-doctoral fellows (MDs MD/PhD and PhDs) and directed the research of 16 resident research fellows in Orthopedic Surgery. Over the years Dr. Gerstenfeld has also provided professional mentorship to visiting faculty scholars and junior faculty members. He is the current Chairman of the Molecular and Transnational Medicine, PhD Qualifying Examine Committee, and is Director of a graduate level course on Core-Bio technologies that provides students with both theoretical and hands on training in large instrumentation Core technologies. He is the co-director of the master’s program of the Boston University Graduate Medical Sciences program in Core Bio technologies. He is also an adviser for the Graduate Medical Sciences Program. He is a member of the Graduate Medical Sciences and Medical School admissions committee at Boston University as well as the Academic Policy Committee that reviews and approves course materials for the Graduate School of Medical Science curriculum at the Boston University Medical School. The majority of his trainees have gone on to academic positions within basic science and clinical departments or become employed in the pharmaceutical and biotechnology industries when they have completed their training. One of his post doctoral trainees was recently awarded a NIH K99 award mentored research award to transition to an independent faculty position. Six of Dr. Gerstenfeld’ s trainees have won a variety of American Society of Bone and Mineral Research or Orthopedic Research Society Young Investigators Awards. He was on the Membership Engagement and Education Committee of the American Society of Bone and Mineral Research 2012-2015 that provides forums for trainee and junior faculty of the Society to obtain resources for career advancement in the field.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Housman (R)
Boston MA 02118
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