Louis C. Gerstenfeld, PhD
Boston University School of Medicine
Dept of Orthopaedic Surgery

PhD, Boston University School of Medicine

My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous pre-clinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues, skeletal tissue cell biology and skeletal tissue transcriptomics. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA and DOD review panels for orthopedic related research and worked on Special Emphasis Review Panels for the FDA. My current work focuses on relating genomic variants that define human bone quality to transcriptomic phenotypes of ostoeblasts and osteoclasts. Other studies in laboratory are focused on developing serum based diagnostics to follow the progression of fracture healing and define delayed and failed healing in humans.

Research Professor
Boston University School of Medicine

Boston University School of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

Boston University
Center for Regenerative Medicine

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Serum Protein Based Indices for the Progression of Fracture Healing and Non-Union
09/30/2019 - 09/29/2023 (PI)
Department of Defense/Army Medical Research Acquisition Activity

A Systems Genetics Approach to Identify BMD Genes
04/01/2018 - 02/28/2023 (Multi-PI)
PI: Louis C. Gerstenfeld, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

The mechanistic role of subchondral bone cysts and bone marrow lesions as markers of cases for hip arthroplasty
07/01/2017 - 12/31/2018 (Co-Investigator)
PI: Eric Smith, MD
Orthopaedic Research and Education Foundation

A Systems Genetic Approach to Fracture Healing
08/01/2016 - 07/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

An Evaluation of Serum Based Indices to Assess Fracture Healing
09/15/2015 - 07/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Role of Angiogenesis in Distraction Osteogenesis
09/01/2011 - 08/31/2017 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Tracking Cell Fate During Mechanically Directed Bone Regeneration In Vivo
06/01/2013 - 05/31/2017 (Co-Investigator)
PI: Elise F. Morgan, PhD
National Science Foundation

A Systems Genetics Approach to Fracture Healing
08/03/2012 - 07/31/2016 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Role of Angiogenesis in Bone Repair
01/01/2012 - 12/31/2014 (PI)
Musculoskeletal Transplant Foundation

Comparison of a Soluble TGF-Beta Receptor Family Protein on Murine Fracture Healing
02/01/2011 - 01/31/2013 (PI)
Acceleron Pharma, Inc

Showing 10 of 35 results. Show All Results


Yr Title Project-Sub Proj Pubs
2021 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-04 1
2020 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-03 1
2020 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-03 1
2019 A Systems Genetics Approach to Identify BMD Genes 3R01AR071657-02S1 1
2019 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-02 1
2018 A Systems Genetics Approach to Identify BMD Genes 1R01AR071657-01A1 1
2016 An Evaluation of Serum Based Indices to Assess Fracture Healing 5R21AR067900-02 2
2016 A Systems Genetics Approach to Fracture Healing 4R01AR059741-05 10
2015 An Evaluation of Serum Based Indices to Assess Fracture Healing 1R21AR067900-01A1 2
2015 A Systems Genetics Approach to Fracture Healing 5R01AR059741-04 10
Showing 10 of 43 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Cui Q, Aksu C, Ay B, Remillard CE, Plagge A, Gardezi M, Dunlap M, Gerstenfeld LC, He Q, Bastepe M. Maternal GNAS Contributes to the Extra-Large G Protein a-Subunit (XLas) Expression in a Cell Type-Specific Manner. Front Genet. 2021; 12:680537. PMID: 34220953; PMCID: PMC8247768; DOI: 10.3389/fgene.2021.680537;
  2. Uda Y, Spatz JM, Hussein A, Garcia JH, Lai F, Dedic C, Fulzele K, Dougherty S, Eberle M, Adamson C, Misener L, Gerstenfeld L, Divieti Pajevic P. Global transcriptomic analysis of a murine osteocytic cell line subjected to spaceflight. FASEB J. 2021 05; 35(5):e21578.View Related Profiles. PMID: 33835498
  3. Morgan EF, Giacomo A, Gerstenfeld LC. Overview of Skeletal Repair (Fracture Healing and Its Assessment). Methods Mol Biol. 2021; 2230:17-37. PMID: 33197006
  4. De Giacomo A, Morgan EF, Gerstenfeld LC. Generation of Closed Transverse Fractures in Small Animals. Methods Mol Biol. 2021; 2230:63-73. PMID: 33197008
  5. Tashkandi MM, Alsaqer SF, Alhousami T, Ali F, Wu YC, Shin J, Mehra P, Wolford LM, Gerstenfeld LC, Goldring MB, Bais MV. LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage. Sci Rep. 2020 11 19; 10(1):20179.View Related Profiles. PMID: 33214607; PMCID: PMC7678826; DOI: 10.1038/s41598-020-77178-9;
  6. Montagna G, Cristofaro F, Fassina L, Bruni G, Cucca L, Kochen A, Divieti Pajevic P, Bragdon B, Visai L, Gerstenfeld L. An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2. Front Bioeng Biotechnol. 2020; 8:499.View Related Profiles. PMID: 32612980; PMCID: PMC7308719; DOI: 10.3389/fbioe.2020.00499;
  7. Reahl GB, Gerstenfeld L, Kain M. Epidemiology, Clinical Assessments, and Current Treatments of Nonunions. Curr Osteoporos Rep. 2020 06; 18(3):157-168.View Related Profiles. PMID: 32318988
  8. Lu D, Tripodis Y, Gerstenfeld LC, Demissie S. Clustering of temporal gene expression data with mixtures of mixed effects models with a penalized likelihood. Bioinformatics. 2019 03 01; 35(5):778-786.View Related Profiles. PMID: 30101356; PMCID: PMC6394398; DOI: 10.1093/bioinformatics/bty696;
  9. Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC. Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm. Sci Rep. 2018 09 13; 8(1):13756.View Related Profiles. PMID: 30213970; PMCID: PMC6137060; DOI: 10.1038/s41598-018-31830-7;
  10. Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol. 2018 09; 233(9):7007-7021.View Related Profiles. PMID: 29380368; PMCID: PMC6827485; DOI: 10.1002/jcp.26495;
Showing 10 of 204 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 204 publications over 40 distinct years, with a maximum of 14 publications in 2003


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bone Histomorphometry
Cell Biology of Skeletal Tissues
Extracellular Matrix
Fracture Healing

Over the last 30 years Dr. Gerstenfeld has participated in mentoring a wide variety of students from high school students to medical resident trainees. At the post graduate level he was the primary thesis adviser to one PhD student 3 MD/PhD students, 11 DMSc students and 52 master’s students. He has mentored 21 post-doctoral fellows (MDs MD/PhD and PhDs) and directed the research of 16 resident research fellows in Orthopedic Surgery. Over the years Dr. Gerstenfeld has also provided professional mentorship to visiting faculty scholars and junior faculty members. He is the current Chairman of the Molecular and Translational Medicine, PhD Qualifying Examine Committee, and is Director of a graduate level course on Core-Bio technologies that provides students with both theoretical and hands on training in large instrumentation Core technologies. He is the co-director of the master’s program of the Boston University Graduate Medical Sciences program in Core Bio technologies. He is also an adviser for the Graduate Medical Sciences Program. He is a member of the Graduate Medical Sciences admissions committee and a former member of the MD/PhD admissions committee at Boston University as well as the Academic Policy Committee that reviews and approves course materials for the Graduate School of Medical Science curriculum at the Boston University Medical School. The majority of his trainees have gone on to academic positions within basic science and clinical departments or become employed in the pharmaceutical and biotechnology industries when they have completed their training. One of his post doctoral trainees was recently awarded a NIH K99 award mentored research award to transition to an independent faculty position. Six of Dr. Gerstenfeld’ s trainees have won a variety of American Society of Bone and Mineral Research or Orthopedic Research Society Young Investigators Awards. He was on the Membership Engagement and Education Committee of the American Society of Bone and Mineral Research 2012-2015 that provides forums for trainee and junior faculty of the Society to obtain resources for career advancement in the field and is a current member of the Basic Sciences Educational Committee of the Orthopedic Research Society.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Housman (R)
Boston MA 02118
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