Louis C. Gerstenfeld, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Orthopaedic Surgery

PhD, Boston University School of Medicine
BA, Pennsylvania State University
BS, Pennsylvania State University



My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous pre-clinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues, skeletal tissue cell biology and skeletal tissue transcriptomics. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA and DOD review panels for orthopedic related research and worked on Special Emphasis Review Panels for the FDA. My current work focuses on relating genomic variants that define human bone quality to transcriptomic phenotypes of ostoeblasts and osteoclasts. Other studies in laboratory are focused on developing serum based diagnostics to follow the progression of fracture healing and define delayed and failed healing in humans.

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology


Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Serum Protein Based Indices for the Progression of Fracture Healing and Non-Union
09/30/2019 - 09/29/2024 (PI)
Department of Defense/Army Medical Research Acquisition Activity


A Systems Genetics Approach to Identify BMD Genes
04/01/2018 - 02/29/2024 (Multi-PI)
PI: Louis C. Gerstenfeld, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR071657-05

The mechanistic role of subchondral bone cysts and bone marrow lesions as markers of cases for hip arthroplasty
07/01/2017 - 12/31/2018 (Co-Investigator)
PI: Eric Smith, MD
Orthopaedic Research and Education Foundation


A Systems Genetic Approach to Fracture Healing
08/01/2016 - 07/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
4R01AR059741-05

An Evaluation of Serum Based Indices to Assess Fracture Healing
09/15/2015 - 07/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR067900-02

Role of Angiogenesis in Distraction Osteogenesis
09/01/2011 - 08/31/2017 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR056637-05

Tracking Cell Fate During Mechanically Directed Bone Regeneration In Vivo
06/01/2013 - 05/31/2017 (Co-Investigator)
PI: Elise F. Morgan, PhD
National Science Foundation
CMMI-1266243

A Systems Genetics Approach to Fracture Healing
08/03/2012 - 07/31/2016 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR059741-04

Role of Angiogenesis in Bone Repair
01/01/2012 - 12/31/2014 (PI)
Musculoskeletal Transplant Foundation


Comparison of a Soluble TGF-Beta Receptor Family Protein on Murine Fracture Healing
02/01/2011 - 01/31/2013 (PI)
Acceleron Pharma, Inc


Showing 10 of 35 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 A Systems Genetics Approach to Identify BMD Genes 3R01AR071657-05S1
2022 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-05
2021 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-04 1
2020 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-03 1
2019 A Systems Genetics Approach to Identify BMD Genes 3R01AR071657-02S1 1
2019 A Systems Genetics Approach to Identify BMD Genes 5R01AR071657-02 1
2018 A Systems Genetics Approach to Identify BMD Genes 1R01AR071657-01A1 1
2016 An Evaluation of Serum Based Indices to Assess Fracture Healing 5R21AR067900-02 2
2016 A Systems Genetics Approach to Fracture Healing 4R01AR059741-05 10
2015 An Evaluation of Serum Based Indices to Assess Fracture Healing 1R21AR067900-01A1 2
Showing 10 of 44 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Liu Y, Ilinski A, Gerstenfeld LC, Bragdon B. Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation. Front Physiol. 2023; 14:1106474.View Related Profiles. PMID: 36793419; PMCID: PMC9922707; DOI: 10.3389/fphys.2023.1106474;
     
  2. Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation. Bone Rep. 2023 Jun; 18:101657.View Related Profiles. PMID: 37425193; PMCID: PMC10323218; DOI: 10.1016/j.bonr.2023.101657;
     
  3. Al-Barghouthi BM, Rosenow WT, Du KP, Heo J, Maynard R, Mesner L, Calabrese G, Nakasone A, Senwar B, Gerstenfeld L, Larner J, Ferguson V, Ackert-Bicknell C, Morgan E, Brautigan D, Farber CR. Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. Elife. 2022 Nov 23; 11. PMID: 36416764; PMCID: PMC9683789; DOI: 10.7554/eLife.77285;
     
  4. Abood A, Mesner L, Rosenow W, Al-Barghouthi BM, Horowitz N, Morgan EF, Gerstenfeld LC, Farber CR. Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci. J Bone Miner Res. 2022 Aug; 37(8):1500-1510.View Related Profiles. PMID: 35695880; PMCID: PMC9545622; DOI: 10.1002/jbmr.4622;
     
  5. Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498.View Related Profiles. PMID: 35880162; PMCID: PMC9307716; DOI: 10.3389/fonc.2022.929498;
     
  6. Nakasone A, Guang Y, Wise A, Kim L, Babbin J, Rathod S, Mitchell AJ, Gerstenfeld LC, Morgan EF. Structural features of subchondral bone cysts and adjacent tissues in hip osteoarthritis. Osteoarthritis Cartilage. 2022 Aug; 30(8):1130-1139.View Related Profiles. PMID: 35569801; PMCID: PMC9296569; DOI: 10.1016/j.joca.2022.03.013;
     
  7. Bragdon BC, Bennie A, Molinelli A, Liu Y, Gerstenfeld LC. Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues. J Cell Physiol. 2022 May; 237(5):2550-2560.View Related Profiles. PMID: 35338481; PMCID: PMC9133217; DOI: 10.1002/jcp.30728;
     
  8. Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579.View Related Profiles. PMID: 35229061; PMCID: PMC8861981; DOI: 10.1002/jbm4.10579;
     
  9. Auger JD, Naik AJ, Murakami AM, Gerstenfeld LC, Morgan EF. Spatial assessment of femoral neck bone density and microstructure in hip osteoarthritis. Bone Rep. 2022 Jun; 16:101155.View Related Profiles. PMID: 34984214; PMCID: PMC8693349; DOI: 10.1016/j.bonr.2021.101155;
     
  10. Cui Q, Aksu C, Ay B, Remillard CE, Plagge A, Gardezi M, Dunlap M, Gerstenfeld LC, He Q, Bastepe M. Maternal GNAS Contributes to the Extra-Large G Protein a-Subunit (XLas) Expression in a Cell Type-Specific Manner. Front Genet. 2021; 12:680537. PMID: 34220953; PMCID: PMC8247768; DOI: 10.3389/fgene.2021.680537;
     
Showing 10 of 214 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 214 publications over 42 distinct years, with a maximum of 14 publications in 2003

YearPublications
19811
19821
19832
19842
19853
19872
19881
19896
19908
19915
19921
19932
19945
19959
19967
19974
19985
19995
20007
20015
20027
200314
20047
20056
20067
20079
200810
20097
20106
20116
20128
20132
20145
20158
20162
20179
20182
20191
20204
20216
20225
20232

2022 Orthopaedic Research Society International Section of Fracture Repair (ISFR) : Lifetime Achievement Award
2022 Orthopaedic Research Society : Class of 2022 Orthopaedic Research Society Fellows
2021 American Society of Bone and Mineral Research: Class 2021 ASBMR Fellows
2014 Evans Foundation Boston University School of Medicine : Outstanding Collaborator Award
1994-1995 NASA/NIH NIAMS : First NASA/NIH NIAMS joint project for experimentation of space flight on Bone Cells
1987-1990 Orthopedic Education and Research Foundation: Research Award
1986-1989 Arthritis Foundation : Arthritis Investigatorship Award
1983-1985 Post-doctoral Fellowship (NRSA : NIH Institute of Child and Human Development,
1976 National Science Foundation : Undergraduate Fellowship
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bone Histomorphometry
Cell Biology of Skeletal Tissues
Extracellular Matrix
Fracture Healing
Osteoporosis

Over the last 30 years Dr. Gerstenfeld has participated in mentoring a wide variety of students from high school students to medical resident trainees. At the post graduate level he was the primary thesis adviser to one PhD student 3 MD/PhD students, 11 DMSc students and 52 master’s students. He has mentored 21 post-doctoral fellows (MDs MD/PhD and PhDs) and directed the research of 16 resident research fellows in Orthopedic Surgery. Over the years Dr. Gerstenfeld has also provided professional mentorship to visiting faculty scholars and junior faculty members. He is the current Chairman of the Molecular and Translational Medicine, PhD Qualifying Examine Committee, and is Director of a graduate level course on Core-Bio technologies that provides students with both theoretical and hands on training in large instrumentation Core technologies. He is the co-director of the master’s program of the Boston University Graduate Medical Sciences program in Core Bio technologies. He is also an adviser for the Graduate Medical Sciences Program. He is a member of the Graduate Medical Sciences admissions committee and a former member of the MD/PhD admissions committee at Boston University as well as the Academic Policy Committee that reviews and approves course materials for the Graduate School of Medical Science curriculum at the Boston University Medical School. The majority of his trainees have gone on to academic positions within basic science and clinical departments or become employed in the pharmaceutical and biotechnology industries when they have completed their training. One of his post doctoral trainees was recently awarded a NIH K99 award mentored research award to transition to an independent faculty position. Six of Dr. Gerstenfeld’ s trainees have won a variety of American Society of Bone and Mineral Research or Orthopedic Research Society Young Investigators Awards. He was on the Membership Engagement and Education Committee of the American Society of Bone and Mineral Research 2012-2015 that provides forums for trainee and junior faculty of the Society to obtain resources for career advancement in the field and is a current member of the Basic Sciences Educational Committee of the Orthopedic Research Society.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Housman (R)
Boston MA 02118
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