Lee E. Goldstein, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

MD, Yale University School of Medicine
PhD, Yale University



Background
Dr. Lee Goldstein received a bachelor’s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women’s Hospital, Boston. Dr. Goldstein joined the Boston University School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007. Most notably, in 2018 Dr. Goldstein’s study in the journal Brain identified evidence of early CTE brain pathology after head impact—even in the absence of signs of concussion, providing the best evidence to date that head impact, not concussion, causes CTE.

Research Interests
Dr. Goldstein’s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.

Awards/Memberships
Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.

Associate Professor
Boston University School of Medicine
Neurology


Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Associate Professor
Boston University School of Medicine
Ophthalmology


Director
Boston University School of Medicine
Molecular Aging & Development Laboratory




Targeting Tau Proteinopathy for Prevention and Treatment of Chronic Traumatic Encephalopathy (CTE) and Related Tau Protein Neurodegenerative Diseases
02/06/2018 - 02/05/2021 (PI)
United Neuroscience, Inc.


Novel Amnion Cell Secretome Biotherapeutic for Traumatic Brain Injury and Chronic Traumatic Encephalopathy
01/04/2019 - 01/04/2021 (PI)
Noveome Biotherapeutics, Inc


Biomarker-Driven Diagnostics and Treatments for Traumatic Brain Injury and Chronic Traumatic Encephalopathy
08/23/2018 - 08/23/2020 (PI)
Biogen, Inc.


lmmunotherapeutic Targeting of Phosphorylated Tau Proteoforms and Treatment of Chronic Traumatic Encephalopathy (CTE)
01/01/2018 - 12/31/2019 (PI)
Pinteon Therapeutics, Inc.


Gadolinium Distribution in Rat Brain After Systemic Administration of Gadolinium-Based Contrast Agents
10/01/2016 - 10/01/2019 (PI)
GE Healthcare, Inc.


The Eye as Window to Brain Injury: Noninvasive Retinal Imaging to Detect and Monitor Acute and Chronic Effects of Neurotrauma
01/01/2018 - 12/31/2018 (PI)
Crown Philanthropies


The Blood-Brain Barrier as a Diagnostic and Therapeutic Target for Traumatic Brain Injury (TBI)
01/01/2017 - 12/31/2017 (PI)
Prairie Minerals Foundation


Visual and Retinal Correlates of Traumatic Brain Injury (TBI): Biology and Behavior
09/19/2014 - 09/30/2017 (PI)
The Children's Hospital Corporation DOD Army Med Resrch


Chronic Effects of Neurotrauma Consortium
09/30/2015 - 09/29/2017 (PI)
Virginia Commonwealth University DOD Army Med Resrch


The Blood-Brain Barrier and Therapeutic Target for Traumatic Brain Injury (TBI)
01/01/2017 - 06/30/2017 (PI)
Crown Philanthropies


Showing 10 of 22 results. Show All Results



Yr Title Project-Sub Proj Pubs
2011 ROLE OF ABETA-PROTEIN AND METAL INTERACTIONS IN ALZHEIMER?S DISEASE 5P41RR010888-15-5144 238
2010 Femtosecond Infrared Laser Ablation Platform 1S10RR026599-01 2
2010 ROLE OF ABETA-ALPHAB CRYSTALLIN INTERACTIONS IN ALZHEIMER?S DISEASE 5P41RR010888-14-6849 238
2010 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 3R01GM075986-05S1 5
2009 ROLE OF ABETA-ALPHAB CRYSTALLIN INTERACTIONS IN ALZHEIMER?S DISEASE 5P41RR010888-13-6208 238
2009 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 5R01GM075986-05 5
2008 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 3R01GM075986-04S1 5
2008 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 7R01GM075986-04 5
2007 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 5R01GM075986-03 5
2007 Alzheimer's Disease beta-Amyloid in the Lens 5K23AG024792-04 1
Showing 10 of 20 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115.View Related Profiles. PMID: 30390709.
     
  2. Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768.View Related Profiles. PMID: 30053297.
     
  3. Goldstein L, Diaz-Arrastia R. Traumatic Brain Injury and Risk of Suicide. JAMA. 2018 08 14; 320(6):554-556. PMID: 30120461.
     
  4. Moore EE, Hohman TJ, Badami FS, Pechman KR, Osborn KE, Acosta LMY, Bell SP, Babicz MA, Gifford KA, Anderson AW, Goldstein LE, Blennow K, Zetterberg H, Jefferson AL. Neurofilament relates to white matter microstructure in older adults. Neurobiol Aging. 2018 Oct; 70:233-241.View Related Profiles. PMID: 30036759.
     
  5. Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901.View Related Profiles. PMID: 29710395.
     
  6. Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 Feb 01; 141(2):422-458.View Related Profiles. PMID: 29360998; DOI: 10.1093/brain/awx350;.
     
  7. Goldstein LE, McKee AC. Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers. JAMA Neurol. 2017 09 01; 74(9):1045-1047.View Related Profiles. PMID: 28738117.
     
  8. Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR, Alosco ML, Solomon TM, Nowinski CJ, McHale L, Cormier KA, Kubilus CA, Martin BM, Murphy L, Baugh CM, Montenigro PH, Chaisson CE, Tripodis Y, Kowall NW, Weuve J, McClean MD, Cantu RC, Goldstein LE, Katz DI, Stern RA, Stein TD, McKee AC. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017 Jul 25; 318(4):360-370.View Related Profiles. PMID: 28742910; DOI: 10.1001/jama.2017.8334;.
     
  9. Wojnarowicz MW, Fisher AM, Minaeva O, Goldstein LE. Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy-These Matters Matter. Front Neurol. 2017; 8:240.View Related Profiles. PMID: 28620350.
     
  10. Dauer LT, Ainsbury EA, Dynlacht J, Hoel D, Klein BEK, Mayer D, Prescott CR, Thornton RH, Vano E, Woloschak GE, Flannery CM, Goldstein LE, Hamada N, Tran PK, Grissom MP, Blakely EA. Guidance on radiation dose limits for the lens of the eye: overview of the recommendations in NCRP Commentary No. 26. Int J Radiat Biol. 2017 Oct; 93(10):1015-1023. PMID: 28346025.
     
Showing 10 of 41 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 17 distinct years, with a maximum of 6 publications in 2018

YearPublications
19992
20003
20012
20031
20041
20061
20071
20091
20102
20113
20124
20131
20141
20154
20164
20174
20186
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Recent (within 3 months)

Small Tau Filaments Big CTE Discovery

Genetic Engineering & Biotechnology News 3/25/2019

Scientists Find New Evidence of What Makes Chronic Traumatic Encephalopathy Unique

Inside Science 3/21/2019

Boston University CTE expert cautions that the NFL’s 24% drop in concussions did NOT necessarily reduce the risk of the degenerative brain disease, calling the findings ‘irrelevant’ to the long-term effects of repetitive head injuries

The Daily Mail 1/30/2019

Older

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Randy Carlyle thought hot brains caused concussions; what if cooling the brain works as treatment?

Pension Plan Puppets 10/22/2018

KARE 11 Investigates: CTE found in Minnesota soldier

KARE 11 9/26/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

Brain Injury May Raise Risk of Suicide

MedPage Today 8/14/2018

Reports of inner-ear damage deepen diplomat controversy

Science Magazine 6/22/2018

Sonic attack or mass paranoia? New evidence stokes debate over diplomats’ mysterious illness

Science Magazine 6/20/2018

Hits to the head may result in immediate brain damage

Boston Business Journal 6/1/2018

Chance Meeting Gives High School Player New Perspective On Dangers Of Football

WGBH News 3/8/2018

Traumatic brain injury linked to increased dementia risk: Report

ABC News 1/31/2018

Hits to the Head May Result in Immediate Brain Damage

The New York Times 1/31/2018

Some parents saying ‘no’ to tackle football over CTE fears

NBC 1/27/2018

Another Rob Gronkowski concussion could be dangerous

Boston Herald 1/23/2018

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