Leveraging novel mouse models to investigate toxic metal exposures on brain aging and Alzheimer's disease09/30/2024 - 08/31/2029 (PI)
NIH/National Institute on Aging1U01AG088683-01
Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research09/30/2023 - 06/30/2028 (Multi-PI)
PI:
Lee E. Goldstein, MD, PhDNIH/National Institute on Aging5R01AG077588-02
Boston University Alzheimer's Disease Research Center08/15/2021 - 06/30/2026 (Key Person)
PI:
Ann C. McKee, MDNIH/National Institute on Aging5P30AG072978-04
Impact of Toxic Metal Exposures in Novel Genetic Mouse Models of Late-Onset Alzheimer's Disease09/15/2023 - 08/31/2025 (PI)
NIH/National Institute on Aging1R56AG083940-01
ICP-TOF Mass Spectrometer for Ultrafast Elemental Mapping of Clinical and Preclinical Biospecimens05/01/2024 - 04/30/2025 (PI)
NIH/National Institutes of Health1S10OD036450-01
Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study05/01/2021 - 04/30/2025 (Multi-PI)
PI:
Lee E. Goldstein, MD, PhDNIH/National Institute on Aging3RF1AG072654-01S2
TBI identification and monitoring through retinal scanning04/01/2022 - 03/31/2025 (Multi-PI)
PI:
Lee E. Goldstein, MD, PhDRebion NIH NINDS5R44NS117553-03
Lens ß-Amyloid Biomarker for Early Detection of Preclinical Alzheimer's Disease in the Framingham Study04/01/2021 - 03/31/2025 (PI)
NIH/National Institute on Aging1RF1AG072589-01
Evaluation of Latent Neurological Effects of Hypobaric Pressure Fluctuations in Physiological Episodes10/27/2021 - 09/25/2024 (Subcontract PI)
Advanced Technology International DOD ArmyMedResDevCmd
IU/JAX/PITT MODEL-AD Center09/01/2023 - 08/31/2024 (Subcontract PI)
Trustees of Indiana University NIH NIA5U54AG054345-08S1
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Big data and small molecules for Alzheimer's disease08/15/2019 - 06/30/2024 (Multi-PI)
PI:
Lee E. Goldstein, MD, PhDNIH/National Institute on Aging3RF1AG063913-01S2
Lasting impacts: Dynamic 3D Human Bioprinted Neurovascular Model to study Traumatic Brain Injury pathophysiology09/22/2022 - 08/31/2023 (Subcontract PI)
Lawrence Livermore National Laboratory DOE/Nal NucSecAdmDE-AC52-07NA27344
Molecular and Cellular Pathways Regulating Neurovascular Dysfunction in Degenerative Tauopathies09/30/2020 - 08/31/2022 (Multi-PI)
PI:
Lee E. Goldstein, MD, PhDNIH/National Institute on Aging1R56AG069115-01
Center for Translational Neurotrauma Imaging (CTNI) at Boston University Medical Center07/01/2019 - 06/30/2021 (Multi-PI)
PI:
Lee E. Goldstein, MD, PhDMassachusetts Life Sciences Center
The Role of Histone Deacetylase 9 in Vascular Calcification06/01/2020 - 05/31/2021 (Subcontract PI)
Massachusetts General Hospital NIH NHLBI3R01HL142809-03S1
Targeting Tau Proteinopathy for Prevention and Treatment of Chronic Traumatic Encephalopathy (CTE) and Related Tau Protein Neurodegenerative Diseases02/06/2018 - 02/05/2021 (PI)
United Neuroscience, Inc.
Novel Amnion
Cell Secretome Biotherapeutic for Traumatic Brain Injury and Chronic Traumatic
Encephalopathy01/04/2019 - 01/04/2021 (PI)
Noveome Biotherapeutics, Inc
From Bench to Bed: Blood-brain barrier as a novel target for diagnosis and treatment01/01/2019 - 12/31/2020 (PI)
Crown Philanthropies
Biomarker-Driven Diagnostics and Treatments for Traumatic Brain Injury and Chronic Traumatic Encephalopathy08/23/2018 - 04/27/2020 (PI)
Biogen, Inc.
lmmunotherapeutic Targeting of Phosphorylated Tau Proteoforms
and Treatment of Chronic Traumatic Encephalopathy (CTE)01/01/2018 - 12/31/2019 (PI)
Pinteon Therapeutics, Inc.
Gadolinium Distribution in Rat Brain After Systemic Administration of Gadolinium-Based Contrast Agents10/01/2016 - 10/01/2019 (PI)
GE Healthcare, Inc.
The Eye as Window to Brain Injury: Noninvasive Retinal Imaging to Detect and Monitor Acute and Chronic Effects of Neurotrauma01/01/2018 - 12/31/2018 (PI)
Crown Philanthropies
The Blood-Brain Barrier as a Diagnostic and Therapeutic Target for Traumatic Brain Injury (TBI)01/01/2017 - 12/31/2017 (PI)
Prairie Minerals Foundation
Visual and Retinal Correlates of Traumatic Brain Injury (TBI): Biology and Behavior09/19/2014 - 09/30/2017 (Subcontract PI)
The Children's Hospital Corporation DOD Army Med Resrch
Chronic Effects of Neurotrauma Consortium09/30/2015 - 09/29/2017 (Subcontract PI)
Virginia Commonwealth University DOD Army Med Resrch
The Blood-Brain Barrier and Therapeutic Target for Traumatic Brain Injury (TBI)01/01/2017 - 06/30/2017 (PI)
Crown Philanthropies
Effects of Space Radiation on Hippocampal-Dependent learning and Neuropathology in Wild-type and Alzheimer's Disease Transgenic Mice09/01/2011 - 02/28/2017 (PI)
NASANNX11AR05G
Effects of Blast Neurotrauma on Alzheimer's Disease Pathogenesis09/16/2013 - 09/15/2016 (PI)
Department of Defense
The Blood-Brain Barrier as a Diagnostic and Therapeutic Target for Traumatic Brain Injury (TBI)01/01/2015 - 05/31/2016 (PI)
Crown Philanthropies
Blood-Brain Barrier Disruption in Blast Neurotrauma08/01/2012 - 07/31/2015 (Key Person / Mentor)
NIH/National Institute of Neurological Disorders & Stroke5F31NS080564-03
Quantifying Acute and Chronic Effects of Traumatic Brain Injury (TBI)07/01/2014 - 06/26/2015 (PI)
Charles Stark Draper Laboratory, Inc.
Progesterone therapy for CTE01/15/2013 - 01/14/2015 (PI)
BHR Pharma, LLC
Elucidating the Pathology of Impact-Induced Traumatic Brain Injury09/01/2011 - 08/31/2014 (Key Person)
NIH/National Institute of Neurological Disorders & Stroke5F31NS077796-03
Orally Active Bioavailable Metal Attenuating Compounds for Alzheimer's Disease10/01/2011 - 09/30/2013 (Subcontract PI)
Board of Regents of the University of Nebraska Alzheimer's Drug Dis
Non-Invasive Detection and Molecular Aanlysis of Early Low X-Ray Dose Effects to the Lens09/01/2009 - 08/31/2013 (PI)
Department of EnergyDE-SC0002213
Metallomic Mapping of the Aging Brain in Trg2576 Transgenic Mouse Model12/29/2011 - 12/28/2012 (PI)
Cure Alzheimer's Fund
Personnel Agreement for Research Services of Olga Minaeva08/01/2011 - 09/30/2011 (PI)
VA Boston Healthcare System
Personnel Agreement for Research Services of Noel Casey08/01/2011 - 09/30/2011 (PI)
VA Boston Healthcare System
Personnel Agreement for Research Services of Juliet Moncaster08/01/2011 - 09/30/2011 (PI)
VA Boston Healthcare System
Personnel agreement for research services of Mark Wojnarowicz08/01/2011 - 09/30/2011 (PI)
VA Boston Healthcare System