Lee E. Goldstein, MD, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Psychiatry

MD, Yale University School of Medicine
PhD, Yale University
BA, Columbia University



Background
Dr. Lee Goldstein received a bachelor’s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women’s Hospital, Boston. Dr. Goldstein joined the Chobanian and Avedisian School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007. Most notably, in 2018 Dr. Goldstein’s study in the journal Brain identified evidence of early CTE brain pathology after head impact—even in the absence of signs of concussion, providing the best evidence to date that head impact, not concussion, causes CTE.

Research Interests
Dr. Goldstein’s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.

Awards/Memberships
Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology


Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine


Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Ophthalmology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director
Boston University Chobanian & Avedisian School of Medicine
Molecular Aging & Development Laboratory


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research
09/30/2023 - 06/30/2028 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
NIH/National Institute on Aging
1R01AG077588-01A1

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

ICP-TOF Mass Spectrometer for Ultrafast Elemental Mapping of Clinical and Preclinical Biospecimens
05/01/2024 - 04/30/2025 (PI)
NIH/National Institutes of Health
1S10OD036450-01

Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study
05/01/2021 - 04/30/2025 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
NIH/National Institute on Aging
3RF1AG072654-01S2

TBI identification and monitoring through retinal scanning
04/01/2022 - 03/31/2025 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
Rebion NIH NINDS
5R44NS117553-03

Lens ß-Amyloid Biomarker for Early Detection of Preclinical Alzheimer's Disease in the Framingham Study
04/01/2021 - 03/31/2025 (PI)
NIH/National Institute on Aging
1RF1AG072589-01

Evaluation of Latent Neurological Effects of Hypobaric Pressure Fluctuations in Physiological Episodes
10/27/2021 - 09/25/2024 (Subcontract PI)
Advanced Technology International DOD ArmyMedResDevCmd


Impact of Toxic Metal Exposures in Novel Genetic Mouse Models of Late-Onset Alzheimer's Disease
09/15/2023 - 08/31/2024 (PI)
NIH/National Institute on Aging
1R56AG083940-01

IU/JAX/PITT MODEL-AD Center
09/01/2023 - 08/31/2024 (Subcontract PI)
Trustees of Indiana University NIH NIA
5U54AG054345-08S1

Big data and small molecules for Alzheimer's disease
08/15/2019 - 06/30/2024 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
NIH/National Institute on Aging
3RF1AG063913-01S2

Showing 10 of 39 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 ICP-TOF Mass Spectrometer for Ultrafast Elemental Mapping of Clinical and Preclinical Biospecimens 1S10OD036450-01
2023 Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research 1R01AG077588-01A1
2023 Impact of Toxic Metal Exposures in Novel Genetic Mouse Models of Late-Onset Alzheimer's Disease 1R56AG083940-01
2023 Lasting Impacts: Dynamic, Fully Natural Bioprinted 3D Human Neurovascular Biomimetic Model to Study Traumatic Brain Injury Pathophysiology 4R33HL159947-03
2023 Core F: Biomarker Core 5P30AG072978-03-9746
2023 Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study: Black & AA Recruitment Supplement 3RF1AG072654-01S2
2023 TBI Identification and Monitoring Through Retinal Scanning 5R44NS117553-03
2022 Core F: Biomarker Core 5P30AG072978-02-9746
2022 Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study 3RF1AG072654-01S1
2022 TBI identification and monitoring through retinal scanning 2R44NS117553-02
Showing 10 of 38 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Culhane JE, Jackson CE, Tripodis Y, Nowinski CJ, Dams-O'Connor K, Pettway E, Uretsky M, Abdolmohammadi B, Nair E, Martin B, Palmisano J, Katz DI, Dwyer B, Daneshvar DH, Goldstein LE, Kowall NW, Cantu RC, Stern RA, Huber BR, Crary JF, Mez J, Stein TD, McKee AC, Alosco ML. Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy. J Neurotrauma. 2024 Apr 15.View Related Profiles. PMID: 38445389
     
  2. Alexander A, Alvarez VE, Huber BR, Alosco ML, Mez J, Tripodis Y, Nicks R, Katz DI, Dwyer B, Daneshvar DH, Martin B, Palmisano J, Goldstein LE, Crary JF, Nowinski C, Cantu RC, Kowall NW, Stern RA, Delalle I, McKee AC, Stein TD. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta Neuropathol. 2024 Feb 26; 147(1):45.View Related Profiles. PMID: 38407651
     
  3. Alosco ML, White M, Bell C, Faheem F, Tripodis Y, Yhang E, Baucom Z, Martin B, Palmisano J, Dams-O'Connor K, Crary JF, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Stern RA, Alvarez VE, Huber BR, Stein TD, McKee AC, Mez J. Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy. Mol Neurodegener. 2024 Feb 06; 19(1):10.View Related Profiles. PMID: 38317248; PMCID: PMC10845638; DOI: 10.1186/s13024-023-00697-2;
     
  4. Sarangi S, Minaeva O, Ledoux DM, Parsons DS, Moncaster JA, Black CA, Hollander J, Tripodis Y, Clark JI, Hunter DG, Goldstein LE. In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome. Exp Eye Res. 2024 Apr; 241:109818.View Related Profiles. PMID: 38422787
     
  5. Montoliu-Gaya L, Alosco ML, Yhang E, Tripodis Y, Sconzo D, Ally M, Grötschel L, Ashton NJ, Lantero-Rodriguez J, Sauer M, Gomes B, Nilsson J, Brinkmalm G, Sugarman MA, Aparicio HJ, Martin B, Palmisano JN, Steinberg EG, Simkin I, Turk KW, Budson AE, Au R, Farrer L, Jun GR, Kowall NW, Stern RA, Goldstein LE, Qiu WQ, Mez J, Huber BR, Alvarez VE, McKee AC, Zetterberg H, Gobom J, Stein TD, Blennow K. Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study. Acta Neuropathol. 2023 Dec 30; 147(1):5.View Related Profiles. PMID: 38159140; PMCID: PMC10757700; DOI: 10.1007/s00401-023-02660-3;
     
  6. Ally M, Sugarman MA, Zetterberg H, Blennow K, Ashton NJ, Karikari TK, Aparicio HJ, Frank B, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Farrer LA, Jun GR, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Kowall NW, Killiany R, Stern RA, Stein TD, McKee AC, Qiu WQ, Mez J, Alosco ML. Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease. Alzheimers Dement (Amst). 2023; 15(4):e12492.View Related Profiles. PMID: 37885919; PMCID: PMC10599277; DOI: 10.1002/dad2.12492;
     
  7. McKee AC, Mez J, Abdolmohammadi B, Butler M, Huber BR, Uretsky M, Babcock K, Cherry JD, Alvarez VE, Martin B, Tripodis Y, Palmisano JN, Cormier KA, Kubilus CA, Nicks R, Kirsch D, Mahar I, McHale L, Nowinski C, Cantu RC, Stern RA, Daneshvar D, Goldstein LE, Katz DI, Kowall NW, Dwyer B, Stein TD, Alosco ML. Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts. JAMA Neurol. 2023 Oct 01; 80(10):1037-1050.View Related Profiles. PMID: 37639244; PMCID: PMC10463175; DOI: 10.1001/jamaneurol.2023.2907;
     
  8. Daneshvar DH, Nair ES, Baucom ZH, Rasch A, Abdolmohammadi B, Uretsky M, Saltiel N, Shah A, Jarnagin J, Baugh CM, Martin BM, Palmisano JN, Cherry JD, Alvarez VE, Huber BR, Weuve J, Nowinski CJ, Cantu RC, Zafonte RD, Dwyer B, Crary JF, Goldstein LE, Kowall NW, Katz DI, Stern RA, Tripodis Y, Stein TD, McClean MD, Alosco ML, McKee AC, Mez J. Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males. Nat Commun. 2023 Jun 20; 14(1):3470.View Related Profiles. PMID: 37340004; PMCID: PMC10281995; DOI: 10.1038/s41467-023-39183-0;
     
  9. Alosco ML, Ly M, Mosaheb S, Saltiel N, Uretsky M, Tripodis Y, Martin B, Palmisano J, Delano-Wood L, Bondi MW, Meng G, Xia W, Daley S, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Stern RA, Alvarez VE, Mez J, Huber BR, McKee AC, Stein TD. Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts. Brain Commun. 2023; 5(2):fcad019.View Related Profiles. PMID: 36895961; PMCID: PMC9990992; DOI: 10.1093/braincomms/fcad019;
     
  10. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 Oct 21; 145(10):3546-3557.View Related Profiles. PMID: 35554506; PMCID: PMC10233293; DOI: 10.1093/brain/awac175;
     
Showing 10 of 80 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 80 publications over 25 distinct years, with a maximum of 8 publications in 2022

YearPublications
19942
19961
19992
20003
20012
20031
20041
20061
20071
20091
20102
20113
20124
20131
20141
20154
20164
20174
20186
20195
20207
20217
20228
20235
20244


Kim Zolciak worries that her ex-NFL player husband Kroy Biermann suffers from brain disorder CTE as she details his 'diabolical' behavior to police… before calling off divorce

Daily Mail 7/15/2023

Super Bowl champion Sam Shields regrets playing in NFL; says his head is ‘all mushed together’ with concussions

CNN 11/3/2022

'I Was Very Broken': Pentagon Addresses Traumatic Brain Injury, the Unseen Wound of War

CBN News 10/6/2022

NFL faces intense scrutiny over concussion protocols

CNN 10/3/2022

'There's Something Wrong with Me': Domestic Abuse Victims Could Have Traumatic Brain Injuries

CBN News 8/9/2022

Veterans May Face Lower Risk for CTE Than Ex-Athletes

HealthDay 6/10/2022

Bill Burr slams NFL for promoting Black Lives Matter while putting 'predominantly black players' at risk of brain injuries by scheduling more games every year

Daily Mail 9/14/2021

Retired NFL quarterback Jay Cutler, 38, predicts 'CTE is coming' for him as he continues to deal with memory issues after suffering an estimated 15 concussions during his career

Daily Mail 6/18/2021

REVEALED: Staff at Florida hotel entered tragic ex-NFL star Vincent Jackson's room twice but thought he was sleeping, so only raised the alarm on the third day

Daily Mail 2/18/2021

Rugby union needs reassurance but science does not offer any easy answers

The Guardian 12/11/2020

Eye scanner can determine real biological age in humans

ZME Science 6/9/2020

Eye scanner measures molecular aging

WCVB 6/9/2020

Pinteon Therapeutics Announces Scientific Advisory Board for Traumatic Brain Injury

Yahoo Finance 5/6/2020

Should Parents Be Afraid To Let Their Kids Play Football?

Five Thirty Eight 1/13/2020

This Helmet Will Save Football. Actually, Probably Not.

The New York Times 12/12/2019

Tag: Dr. Lee Goldstein Worries about CTE Altering the Way Soccer is Played

Global Sport Matters 12/5/2019

New lightweight, elastic helmet padding ‘could reduce the risk of head injuries to football players’ but top expert cautions that is cannot prevent the degenerative brain disease CTE

Daily Mail 11/27/2019

Hope for Patients with Traumatic Brain Injury

AAMC News 10/24/2019

NFL bans multiple violent practice drills to limit concussions as commissioner Roger Goodell targets training camp as a time when the league 'could make greater improvement' to protect players

Daily Mail 5/28/2019

Small Tau Filaments Big CTE Discovery

Genetic Engineering & Biotechnology News 3/25/2019

Scientists Find New Evidence of What Makes Chronic Traumatic Encephalopathy Unique

Inside Science 3/21/2019

Boston University CTE expert cautions that the NFL’s 24% drop in concussions did NOT necessarily reduce the risk of the degenerative brain disease, calling the findings ‘irrelevant’ to the long-term effects of repetitive head injuries

The Daily Mail 1/30/2019

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Randy Carlyle thought hot brains caused concussions; what if cooling the brain works as treatment?

Pension Plan Puppets 10/22/2018

KARE 11 Investigates: CTE found in Minnesota soldier

KARE 11 9/26/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

Brain Injury May Raise Risk of Suicide

MedPage Today 8/14/2018

Reports of inner-ear damage deepen diplomat controversy

Science Magazine 6/22/2018

Sonic attack or mass paranoia? New evidence stokes debate over diplomats’ mysterious illness

Science Magazine 6/20/2018

Hits to the head may result in immediate brain damage

Boston Business Journal 6/1/2018

Chance Meeting Gives High School Player New Perspective On Dangers Of Football

WGBH News 3/8/2018

Traumatic brain injury linked to increased dementia risk: Report

ABC News 1/31/2018

Hits to the Head May Result in Immediate Brain Damage

The New York Times 1/31/2018

Some parents saying ‘no’ to tackle football over CTE fears

NBC 1/27/2018

Another Rob Gronkowski concussion could be dangerous

Boston Herald 1/23/2018
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