Lee E. Goldstein, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

MD, Yale University School of Medicine
PhD, Yale University




Background
Dr. Lee Goldstein received a bachelor’s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women’s Hospital, Boston. Dr. Goldstein joined the Boston University School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007. Most notably, in 2018 Dr. Goldstein’s study in the journal Brain identified evidence of early CTE brain pathology after head impact—even in the absence of signs of concussion, providing the best evidence to date that head impact, not concussion, causes CTE.

Research Interests
Dr. Goldstein’s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.

Awards/Memberships
Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.

Associate Professor
Boston University School of Medicine
Neurology


Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Associate Professor
Boston University School of Medicine
Ophthalmology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director
Boston University School of Medicine
Molecular Aging & Development Laboratory


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Big data and small molecules for Alzheimer's disease
08/15/2019 - 03/31/2024 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
NIH/National Institute on Aging
3RF1AG063913-01S1

Molecular and Cellular Pathways Regulating Neurovascular Dysfunction in Degenerative Tauopathies
09/30/2020 - 08/31/2021 (PI)
NIH/National Institute on Aging
1R56AG069115-01

Center for Translational Neurotrauma Imaging (CTNI) at Boston University Medical Center
07/01/2019 - 06/30/2021 (Co-PI)
PI: Stephan W. Anderson, MD
Massachusetts Life Sciences Center


The Role of Histone Deacetylase 9 in Vascular Calcification
06/01/2020 - 05/31/2021 (Subcontract PI)
Massachusetts General Hospital NIH NHLBI
3R01HL142809-03S1

Targeting Tau Proteinopathy for Prevention and Treatment of Chronic Traumatic Encephalopathy (CTE) and Related Tau Protein Neurodegenerative Diseases
02/06/2018 - 02/05/2021 (PI)
United Neuroscience, Inc.


Novel Amnion Cell Secretome Biotherapeutic for Traumatic Brain Injury and Chronic Traumatic Encephalopathy
01/04/2019 - 01/04/2021 (PI)
Noveome Biotherapeutics, Inc


From Bench to Bed: Blood-brain barrier as a novel target for diagnosis and treatment
01/01/2019 - 12/31/2020 (PI)
Crown Philanthropies


Biomarker-Driven Diagnostics and Treatments for Traumatic Brain Injury and Chronic Traumatic Encephalopathy
08/23/2018 - 04/27/2020 (PI)
Biogen, Inc.


lmmunotherapeutic Targeting of Phosphorylated Tau Proteoforms and Treatment of Chronic Traumatic Encephalopathy (CTE)
01/01/2018 - 12/31/2019 (PI)
Pinteon Therapeutics, Inc.


Gadolinium Distribution in Rat Brain After Systemic Administration of Gadolinium-Based Contrast Agents
10/01/2016 - 10/01/2019 (PI)
GE Healthcare, Inc.


Showing 10 of 27 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Big data and small molecules for Alzheimer's disease 3RF1AG063913-01S1
2019 Big data and small molecules for Alzheimer's disease 1RF1AG063913-01
2011 ROLE OF ABETA-PROTEIN AND METAL INTERACTIONS IN ALZHEIMER?S DISEASE 5P41RR010888-15-5144 259
2010 Femtosecond Infrared Laser Ablation Platform 1S10RR026599-01 2
2010 ROLE OF ABETA-ALPHAB CRYSTALLIN INTERACTIONS IN ALZHEIMER?S DISEASE 5P41RR010888-14-6849 259
2010 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 3R01GM075986-05S1 5
2009 ROLE OF ABETA-ALPHAB CRYSTALLIN INTERACTIONS IN ALZHEIMER?S DISEASE 5P41RR010888-13-6208 259
2009 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 5R01GM075986-05 5
2008 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 3R01GM075986-04S1 5
2008 AD LENS PATHOLOGY: BIOCHEMISTRY &DIAGNOSTIC IMAGING 7R01GM075986-04 5
Showing 10 of 22 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Adams JW, Alosco ML, Mez J, Alvarez VE, Huber BR, Tripodis Y, Adler CH, Kubilius C, Cormier KA, Mathais R, Nicks R, Kelley HJ, Saltiel N, Uretsky M, Nair E, Aytan N, Cherry JD, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy. Acta Neuropathol. 2020 Dec; 140(6):851-862.View Related Profiles. PMID: 32939646
     
  2. Minaeva O, Sarangi S, Ledoux DM, Moncaster JA, Parsons DS, Washicosky KJ, Black CA, Weng FJ, Ericsson M, Moir RD, Tripodis Y, Clark JI, Tanzi RE, Hunter DG, Goldstein LE. In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans. J Gerontol A Biol Sci Med Sci. 2020 Sep 16; 75(9):e53-e62.View Related Profiles. PMID: 32515825; DOI: 10.1093/gerona/glaa121;
     
  3. Alosco ML, Cherry JD, Huber BR, Tripodis Y, Baucom Z, Kowall NW, Saltiel N, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Palmisano JN, Martin B, Cantu RC, Stern RA, Alvarez VE, Mez J, Stein TD, McKee AC. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme. Acta Neuropathol. 2020 Oct; 140(4):495-512.View Related Profiles. PMID: 32778942
     
  4. Cherry JD, Babcock KJ, Goldstein LE. Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms. Semin Neurol. 2020 08; 40(4):430-438.View Related Profiles. PMID: 32674181
     
  5. Veksler R, Vazana U, Serlin Y, Prager O, Ofer J, Shemen N, Fisher AM, Minaeva O, Hua N, Saar-Ashkenazy R, Benou I, Riklin-Raviv T, Parker E, Mumby G, Kamintsky L, Beyea S, Bowen CV, Shelef I, O'Keeffe E, Campbell M, Kaufer D, Goldstein LE, Friedman A. Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players. Brain. 2020 Jun 01; 143(6):1826-1842.View Related Profiles. PMID: 32464655
     
  6. Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisano JN, Steinberg EG, Simkin I, Budson AE, Killiany R, O'Connor MK, Au R, Qiu WWQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiol Aging. 2020 Oct; 94:60-70.View Related Profiles. PMID: 32585491; DOI: 10.1016/j.neurobiolaging.2020.05.011;
     
  7. Li M, Reisman J, Morris-Eppolito B, Qian SX, Kazis LE, Wolozin B, Goldstein LE, Xia W. Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer's disease after traumatic brain injury. Alzheimers Res Ther. 2020 03 27; 12(1):33.View Related Profiles. PMID: 32220235
     
  8. Minaeva O, Hua N, Franz ES, Lupoli N, Mian AZ, Farris CW, Hildebrandt AM, Kiernan PT, Evers LE, Griffin AD, Liu X, Chancellor SE, Babcock KJ, Moncaster JA, Jara H, Alvarez VE, Huber BR, Guermazi A, Latour LL, McKee AC, Soto JA, Anderson SW, Goldstein LE. Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans. Radiology. 2020 02; 294(2):377-385.View Related Profiles. PMID: 31769744
     
  9. Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT, Evers L, Marshall L, Martin BM, Palmisano JN, Nowinski CJ, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Huber BR, Stein TD, Goldstein LE, Katz DI, Cantu RC, Au R, Kowall NW, Stern RA, McClean MD, Weuve J, Tripodis Y, McKee AC. Duration of American Football Play and Chronic Traumatic Encephalopathy. Ann Neurol. 2020 01; 87(1):116-131.View Related Profiles. PMID: 31589352; DOI: 10.1002/ana.25611;
     
  10. Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, Martin B, Cherry JD, Mahar I, Killiany RJ, McClean MD, Au R, Alvarez V, Stern RA, Mez J, McKee AC. Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. JAMA Neurol. 2019 Aug 05.View Related Profiles. PMID: 31380975; DOI: 10.1001/jamaneurol.2019.2244;
     
Showing 10 of 53 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 19 distinct years, with a maximum of 7 publications in 2020

YearPublications
19992
20003
20012
20031
20041
20061
20071
20091
20102
20113
20124
20131
20141
20154
20164
20174
20186
20195
20207


Eye scanner can determine real biological age in humans

ZME Science 6/9/2020

Eye scanner measures molecular aging

WCVB 6/9/2020

Pinteon Therapeutics Announces Scientific Advisory Board for Traumatic Brain Injury

Yahoo Finance 5/6/2020

Should Parents Be Afraid To Let Their Kids Play Football?

Five Thirty Eight 1/13/2020

This Helmet Will Save Football. Actually, Probably Not.

The New York Times 12/12/2019

Tag: Dr. Lee Goldstein Worries about CTE Altering the Way Soccer is Played

Global Sport Matters 12/5/2019

New lightweight, elastic helmet padding ‘could reduce the risk of head injuries to football players’ but top expert cautions that is cannot prevent the degenerative brain disease CTE

Daily Mail 11/27/2019

Hope for Patients with Traumatic Brain Injury

AAMC News 10/24/2019

NFL bans multiple violent practice drills to limit concussions as commissioner Roger Goodell targets training camp as a time when the league 'could make greater improvement' to protect players

Daily Mail 5/28/2019

Small Tau Filaments Big CTE Discovery

Genetic Engineering & Biotechnology News 3/25/2019

Scientists Find New Evidence of What Makes Chronic Traumatic Encephalopathy Unique

Inside Science 3/21/2019

Boston University CTE expert cautions that the NFL’s 24% drop in concussions did NOT necessarily reduce the risk of the degenerative brain disease, calling the findings ‘irrelevant’ to the long-term effects of repetitive head injuries

The Daily Mail 1/30/2019

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Randy Carlyle thought hot brains caused concussions; what if cooling the brain works as treatment?

Pension Plan Puppets 10/22/2018

KARE 11 Investigates: CTE found in Minnesota soldier

KARE 11 9/26/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

Brain Injury May Raise Risk of Suicide

MedPage Today 8/14/2018

Reports of inner-ear damage deepen diplomat controversy

Science Magazine 6/22/2018

Sonic attack or mass paranoia? New evidence stokes debate over diplomats’ mysterious illness

Science Magazine 6/20/2018

Hits to the head may result in immediate brain damage

Boston Business Journal 6/1/2018

Chance Meeting Gives High School Player New Perspective On Dangers Of Football

WGBH News 3/8/2018

Traumatic brain injury linked to increased dementia risk: Report

ABC News 1/31/2018

Hits to the Head May Result in Immediate Brain Damage

The New York Times 1/31/2018

Some parents saying ‘no’ to tackle football over CTE fears

NBC 1/27/2018

Another Rob Gronkowski concussion could be dangerous

Boston Herald 1/23/2018
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