Lee E. Goldstein, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

MD, Yale University School of Medicine
PhD, Yale University




Background
Dr. Lee Goldstein received a bachelor’s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women’s Hospital, Boston. Dr. Goldstein joined the Boston University School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007. Most notably, in 2018 Dr. Goldstein’s study in the journal Brain identified evidence of early CTE brain pathology after head impact—even in the absence of signs of concussion, providing the best evidence to date that head impact, not concussion, causes CTE.

Research Interests
Dr. Goldstein’s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.

Awards/Memberships
Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.

Associate Professor
Boston University School of Medicine
Neurology


Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Associate Professor
Boston University School of Medicine
Ophthalmology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director
Boston University School of Medicine
Molecular Aging & Development Laboratory


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study
05/01/2021 - 04/30/2024 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
NIH/National Institute on Aging
1RF1AG072654-01

Lens ß-Amyloid Biomarker for Early Detection of Preclinical Alzheimer's Disease in the Framingham Study
04/01/2021 - 03/31/2024 (PI)
NIH/National Institute on Aging
1RF1AG072589-01

Big data and small molecules for Alzheimer's disease
08/15/2019 - 03/31/2024 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
NIH/National Institute on Aging
3RF1AG063913-01S2

Evaluation of Latent Neurological Effects of Hypobaric Pressure Fluctuations in Physiological Episodes
10/27/2021 - 09/25/2023 (Subcontract PI)
Advanced Technology International DOD ArmyMedResDevCmd


Molecular and Cellular Pathways Regulating Neurovascular Dysfunction in Degenerative Tauopathies
09/30/2020 - 08/31/2022 (PI)
NIH/National Institute on Aging
1R56AG069115-01

Center for Translational Neurotrauma Imaging (CTNI) at Boston University Medical Center
07/01/2019 - 06/30/2021 (Multi-PI)
PI: Lee E. Goldstein, MD, PhD
Massachusetts Life Sciences Center


The Role of Histone Deacetylase 9 in Vascular Calcification
06/01/2020 - 05/31/2021 (Subcontract PI)
Massachusetts General Hospital NIH NHLBI
3R01HL142809-03S1

Targeting Tau Proteinopathy for Prevention and Treatment of Chronic Traumatic Encephalopathy (CTE) and Related Tau Protein Neurodegenerative Diseases
02/06/2018 - 02/05/2021 (PI)
United Neuroscience, Inc.


Novel Amnion Cell Secretome Biotherapeutic for Traumatic Brain Injury and Chronic Traumatic Encephalopathy
01/04/2019 - 01/04/2021 (PI)
Noveome Biotherapeutics, Inc


From Bench to Bed: Blood-brain barrier as a novel target for diagnosis and treatment
01/01/2019 - 12/31/2020 (PI)
Crown Philanthropies


Showing 10 of 32 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Core F: Biomarker Core 5P30AG072978-02-9746
2022 Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study 3RF1AG072654-01S1
2022 TBI identification and monitoring through retinal scanning 2R44NS117553-02
2021 Lasting Impacts: Dynamic, Fully Natural Bioprinted 3D Human Neurovascular Biomimetic Model to Study Traumatic Brain Injury Pathophysiology 1R61HL159947-01
2021 Core F: Biomarker Core 1P30AG072978-01-9746
2021 Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study 1RF1AG072654-01
2021 Lens ?-Amyloid Biomarker for Early Detection of Preclinical Alzheimer's Disease in the Framingham Study 1RF1AG072589-01
2021 Big data and small molecules for Alzheimer's disease 3RF1AG063913-01S2
2020 Molecular and Cellular Pathways Regulating Neurovascular Dysfunction in Degenerative Tauopathies 1R56AG069115-01
2020 Big data and small molecules for Alzheimer's disease 3RF1AG063913-01S1
Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Atherton K, Han X, Chung J, Cherry JD, Baucom Z, Saltiel N, Nair E, Abdolmohammadi B, Uretsky M, Khan MM, Shea C, Durape S, Martin BM, Palmisano JN, Farrell K, Nowinski CJ, Alvarez VE, Dwyer B, Daneshvar DH, Katz DI, Goldstein LE, Cantu RC, Kowall NW, Alosco ML, Huber BR, Tripodis Y, Crary JF, Farrer L, Stern RA, Stein TD, McKee AC, Mez J. Association of APOE Genotypes and Chronic Traumatic Encephalopathy. JAMA Neurol. 2022 Aug 01; 79(8):787-796.View Related Profiles. PMID: 35759276; PMCID: PMC9237800; DOI: 10.1001/jamaneurol.2022.1634;
     
  2. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 May 13.View Related Profiles. PMID: 35554506; DOI: 10.1093/brain/awac175;
     
  3. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Jun 14; 98(24):e2454-e2464.View Related Profiles. PMID: 35444054; PMCID: PMC9231841; DOI: 10.1212/WNL.0000000000200304;
     
  4. Babcock KJ, Abdolmohammadi B, Kiernan PT, Mahar I, Cherry JD, Alvarez VE, Goldstein LE, Stein TD, McKee AC, Huber BR. Interface astrogliosis in contact sport head impacts and military blast exposure. Acta Neuropathol Commun. 2022 Apr 13; 10(1):52.View Related Profiles. PMID: 35418116; PMCID: PMC9009003; DOI: 10.1186/s40478-022-01358-z;
     
  5. Moncaster JA, Moir RD, Burton MA, Chadwick O, Minaeva O, Alvarez VE, Ericsson M, Clark JI, McKee AC, Tanzi RE, Goldstein LE. Alzheimer's disease amyloid-ß pathology in the lens of the eye. Exp Eye Res. 2022 Aug; 221:108974.View Related Profiles. PMID: 35202705
     
  6. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles. PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;
     
  7. Alosco ML, Mian AZ, Buch K, Farris CW, Uretsky M, Tripodis Y, Baucom Z, Martin B, Palmisano J, Puzo C, Ang TFA, Joshi P, Goldstein LE, Au R, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Huber BR, Alvarez VE, Stern RA, Stein TD, Killiany RJ, McKee AC, Mez J. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE. Alzheimers Res Ther. 2021 12 07; 13(1):193.View Related Profiles. PMID: 34876229; PMCID: PMC8653514; DOI: 10.1186/s13195-021-00928-y;
     
  8. Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkina I, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Jun GR, Kowall NW, Stein TD, McKee AC, Killiany R, Qiu WQ, Stern RA, Mez J, Alosco ML. Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimers Dement. 2022 Aug; 18(8):1523-1536.View Related Profiles. PMID: 34854549; PMCID: PMC9160800; DOI: 10.1002/alz.12508;
     
  9. Uretsky M, Bouix S, Killiany RJ, Tripodis Y, Martin B, Palmisano J, Mian AZ, Buch K, Farris C, Daneshvar DH, Dwyer B, Goldstein L, Katz D, Nowinski C, Cantu R, Kowall N, Huber BR, Stern RA, Alvarez VE, Stein TD, McKee A, Mez J, Alosco ML. Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts. Neurology. 2022 01 04; 98(1):e27-e39.View Related Profiles. PMID: 34819338; PMCID: PMC8726571; DOI: 10.1212/WNL.0000000000013012;
     
  10. Tao Q, Alvin Ang TF, Akhter-Khan SC, Itchapurapu IS, Killiany R, Zhang X, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML, Qiu WQ. Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous Apolipoprotein E ?4 Carriers. Neurology. 2021 Jul 15.View Related Profiles. PMID: 34266923; PMCID: PMC8480484; DOI: 10.1212/WNL.0000000000012512;
     
Showing 10 of 69 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 69 publications over 23 distinct years, with a maximum of 7 publications in 2020 and 2021

YearPublications
19942
19961
19992
20003
20012
20031
20041
20061
20071
20091
20102
20113
20124
20131
20141
20154
20164
20174
20186
20195
20207
20217
20226


Recent (within 3 months)

'There's Something Wrong with Me': Domestic Abuse Victims Could Have Traumatic Brain Injuries

CBN News 8/9/2022

Older

Veterans May Face Lower Risk for CTE Than Ex-Athletes

HealthDay 6/10/2022

Bill Burr slams NFL for promoting Black Lives Matter while putting 'predominantly black players' at risk of brain injuries by scheduling more games every year

Daily Mail 9/14/2021

Retired NFL quarterback Jay Cutler, 38, predicts 'CTE is coming' for him as he continues to deal with memory issues after suffering an estimated 15 concussions during his career

Daily Mail 6/18/2021

REVEALED: Staff at Florida hotel entered tragic ex-NFL star Vincent Jackson's room twice but thought he was sleeping, so only raised the alarm on the third day

Daily Mail 2/18/2021

Rugby union needs reassurance but science does not offer any easy answers

The Guardian 12/11/2020

Eye scanner can determine real biological age in humans

ZME Science 6/9/2020

Eye scanner measures molecular aging

WCVB 6/9/2020

Pinteon Therapeutics Announces Scientific Advisory Board for Traumatic Brain Injury

Yahoo Finance 5/6/2020

Should Parents Be Afraid To Let Their Kids Play Football?

Five Thirty Eight 1/13/2020

This Helmet Will Save Football. Actually, Probably Not.

The New York Times 12/12/2019

Tag: Dr. Lee Goldstein Worries about CTE Altering the Way Soccer is Played

Global Sport Matters 12/5/2019

New lightweight, elastic helmet padding ‘could reduce the risk of head injuries to football players’ but top expert cautions that is cannot prevent the degenerative brain disease CTE

Daily Mail 11/27/2019

Hope for Patients with Traumatic Brain Injury

AAMC News 10/24/2019

NFL bans multiple violent practice drills to limit concussions as commissioner Roger Goodell targets training camp as a time when the league 'could make greater improvement' to protect players

Daily Mail 5/28/2019

Small Tau Filaments Big CTE Discovery

Genetic Engineering & Biotechnology News 3/25/2019

Scientists Find New Evidence of What Makes Chronic Traumatic Encephalopathy Unique

Inside Science 3/21/2019

Boston University CTE expert cautions that the NFL’s 24% drop in concussions did NOT necessarily reduce the risk of the degenerative brain disease, calling the findings ‘irrelevant’ to the long-term effects of repetitive head injuries

The Daily Mail 1/30/2019

'No Safe Blow to the Head': Why One Season of Childhood Football Likely Means Irreversible Brain Damage

CBN News 12/10/2018

Randy Carlyle thought hot brains caused concussions; what if cooling the brain works as treatment?

Pension Plan Puppets 10/22/2018

KARE 11 Investigates: CTE found in Minnesota soldier

KARE 11 9/26/2018

Combat veterans coming home with CTE

CBS News 9/16/2018

Brain Injury May Raise Risk of Suicide

MedPage Today 8/14/2018

Reports of inner-ear damage deepen diplomat controversy

Science Magazine 6/22/2018

Sonic attack or mass paranoia? New evidence stokes debate over diplomats’ mysterious illness

Science Magazine 6/20/2018

Hits to the head may result in immediate brain damage

Boston Business Journal 6/1/2018

Chance Meeting Gives High School Player New Perspective On Dangers Of Football

WGBH News 3/8/2018

Traumatic brain injury linked to increased dementia risk: Report

ABC News 1/31/2018

Hits to the Head May Result in Immediate Brain Damage

The New York Times 1/31/2018

Some parents saying ‘no’ to tackle football over CTE fears

NBC 1/27/2018

Another Rob Gronkowski concussion could be dangerous

Boston Herald 1/23/2018
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