Josee Dupuis, PhD
Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Stanford University
MS, Stanford University




Josée Dupuis, Ph.D, is a Professor and Chair of Biostatistics at Boston University School of Public Health. She previously held a faculty position at Northwestern University and a senior statistical geneticist position at Genome Therapeutics Corporation, a small biotech company. She has extensive experience in the development and application of methods for genome-wide association studies, gene by environment interaction investigation, genetic meta-analysis and rare variant analysis, with special emphasis on the development of novel statistical approaches to analyze genetic data collected on large families. She is involved in the Framingham Heart Study, collaborating on projects to identify genes influencing diabetes related traits, pulmonary function traits and atrial fibrillation. She teaches BS860 (Statistical Genetics II) in the spring semester of even years.

Chair of Biostatistics
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Bioinformatics Graduate Program


Member
Boston University
Genome Science Institute



2020 American Society of Human Genetics : Mentorship Award
2019 International Genetic Epidemiology (IGES) : Leadership Award
2019 University of Colorado, Denver: Benjamin F. Stapleton, Jr. Lecture
2015 American Association for the Advancement of Science (AAAS): Fellow of the American Association for the Advancement of Science
2015 Boston University School of Public Health: Faculty Career Award in Research and Scholarship
2014 Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Senior Leadership Award
2013 American Statistical Association: Fellow of the American Statistical Association


TOPMed Omics of Cardiovascular Disease in Diabetes
07/01/2020 - 06/30/2024 (Subcontract PI)
Massachusetts General Hospital NIH NHLBI
1R01HL151855-01

Nutritional Omics of Pulmonary Function Decline
11/15/2019 - 07/31/2023 (Subcontract PI)
RTI International NIH NHLBI
1R01HL149352-01

The Role of Genetic Susceptibility in Central American Kidney Disease Epidemic
07/01/2018 - 06/30/2023 (Co-Investigator of Sub-Project / SP)
PI: Daniel Brooks, DSc
NIH/National Diabetes & Digestive & Kidney Diseases
3R01DK116021-03S1

VA241-16-D-0012 VA Master Contract Task Order 23 (Luke Ruscowitz-Orazem)
09/01/2020 - 08/31/2021 (PI)
VA Boston Healthcare System


Vertex Pharmaceuticals Fellowship (Katherine Bloore)
09/01/2019 - 08/31/2021 (PI)
Vertex Pharmaceuticals Incorporated


Vertex Pharmaceuticals Fellowship (Xiaoyan Liu)
09/01/2019 - 08/31/2021 (PI)
Vertex Pharmaceuticals Incorporated


Mechanism connecting dysregulated BCAA glucose and lipid metabolism in the pathogenesis of metabolic disease
08/19/2019 - 07/31/2021 (Subcontract PI)
Duke University NIH NIDDK
5R01DK121710-02

TOPMed Contribution to the AMP-T2D Knowledge Portal
04/01/2019 - 05/31/2021 (Co-Investigator)
PI: Ching-Ti Liu, PhD
Foundation for the National Institutes of Health


TOPMed Whole Genome Sequence Analysis of Type 2 Diabetes and Related Traits
05/01/2017 - 04/30/2021 (Subcontract PI)
The Broad Institute, Inc. NIH NIDDK
5U01DK105554-04

Statistical Research support for Biostatistics Student (Daniel Posner)
02/01/2016 - 01/31/2021 (PI)
VA Boston Healthcare System


Showing 10 of 38 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Yang T, Jackson VE, Smith AV, Chen H, Bartz TM, Sitlani CM, Psaty BM, Gharib SA, O'Connor GT, Dupuis J, Xu J, Lohman K, Liu Y, Kritchevsky SB, Cassano PA, Flexeder C, Gieger C, Karrasch S, Peters A, Schulz H, Harris SE, Starr JM, Deary IJ, Manichaikul A, Oelsner EC, Barr RG, Taylor KD, Rich SS, Bonten TN, Mook-Kanamori DO, Noordam R, Li-Gao R, Jarvelin MR, Wielscher M, Terzikhan N, Lahousse L, Brusselle G, Weiss S, Ewert R, Gläser S, Homuth G, Shrine N, Hall IP, Tobin M, London SJ, Wei P, Morrison AC. Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function. Sci Rep. 2021 Sep 29; 11(1):19365.View Related Profiles. PMID: 34588469; PMCID: PMC8481467; DOI: 10.1038/s41598-021-98120-7;
     
  2. Prescott BR, Saglam H, Duskin JA, Miller MI, Thakur AS, Gholap EA, Hutch MR, Smirnakis SM, Zafar SF, Dupuis J, Benjamin EJ, Greer DM, Ong CJ. Anisocoria and Poor Pupil Reactivity by Quantitative Pupillometry in Patients With Intracranial Pathology. Crit Care Med. 2021 Sep 22.View Related Profiles. PMID: 34637415
     
  3. Merino J, Dashti HS, Sarnowski C, Lane JM, Todorov PV, Udler MS, Song Y, Wang H, Kim J, Tucker C, Campbell J, Tanaka T, Chu AY, Tsai L, Pers TH, Chasman DI, Rutter MK, Dupuis J, Florez JC, Saxena R. Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits. Nat Hum Behav. 2021 Aug 23. PMID: 34426670
     
  4. Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Pitkänen N, Young KL, Graff M, Wood AC, Braun KVE, Luan J, Kähönen M, Kiefte-de Jong JC, Ghanbari M, Tintle N, Lemaitre RN, Mook-Kanamori DO, North K, Helminen M, Mossavar-Rahmani Y, Snetselaar L, Martin LW, Viikari JS, Oddy WH, Pennell CE, Rosendall FR, Ikram MA, Uitterlinden AG, Psaty BM, Mozaffarian D, Rotter JI, Taylor KD, Lehtimäki T, Raitakari OT, Livingston KA, Voortman T, Forouhi NG, Wareham NJ, de Mutsert R, Rich SS, Manson JE, Mora S, Ridker PM, Merino J, Meigs JB, Dashti HS, Chasman DI, Lichtenstein AH, Smith CE, Dupuis J, Herman MA, McKeown NM. Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations. Circ Genom Precis Med. 2021 Aug; 14(4):e003288.View Related Profiles. PMID: 34270325; PMCID: PMC8373451; DOI: 10.1161/CIRCGEN.120.003288;
     
  5. Keefe J, Yao C, Hwang SJ, Courchesne P, Lee GY, Dupuis J, Mizgerd JP, O'Connor G, Washko GR, Cho MH, Silverman EK, Levy D. An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function. Chest. 2021 Jul 06.View Related Profiles. PMID: 34237330
     
  6. Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021 Jun 14. PMID: 34127525
     
  7. Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Córdova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, García-Ortiz H, Gieger C, Glaser B, González-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jørgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martínez-Hernández A, Meigs JB, Meitinger T, Mendoza-Caamal E, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusié-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 06 09; 12(1):3505.View Related Profiles. PMID: 34108472; PMCID: PMC8190084; DOI: 10.1038/s41467-021-23556-4;
     
  8. Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, Mägi R, Waage J, Li-Gao R, Chan KHK, Yao J, Anasanti MD, Chu AY, Claringbould A, Heikkinen J, Hong J, Hottenga JJ, Huo S, Kaakinen MA, Louie T, März W, Moreno-Macias H, Ndungu A, Nelson SC, Nolte IM, North KE, Raulerson CK, Ray D, Rohde R, Rybin D, Schurmann C, Sim X, Southam L, Stewart ID, Wang CA, Wang Y, Wu P, Zhang W, Ahluwalia TS, Appel EVR, Bielak LF, Brody JA, Burtt NP, Cabrera CP, Cade BE, Chai JF, Chai X, Chang LC, Chen CH, Chen BH, Chitrala KN, Chiu YF, de Haan HG, Delgado GE, Demirkan A, Duan Q, Engmann J, Fatumo SA, Gayán J, Giulianini F, Gong JH, Gustafsson S, Hai Y, Hartwig FP, He J, Heianza Y, Huang T, Huerta-Chagoya A, Hwang MY, Jensen RA, Kawaguchi T, Kentistou KA, Kim YJ, Kleber ME, Kooner IK, Lai S, Lange LA, Langefeld CD, Lauzon M, Li M, Ligthart S, Liu J, Loh M, Long J, Lyssenko V, Mangino M, Marzi C, Montasser ME, Nag A, Nakatochi M, Noce D, Noordam R, Pistis G, Preuss M, Raffield L, Rasmussen-Torvik LJ, Rich SS, Robertson NR, Rueedi R, Ryan K, Sanna S, Saxena R, Schraut KE, Sennblad B, Setoh K, Smith AV, Sparsø T, Strawbridge RJ, Takeuchi F, Tan J, Trompet S, van den Akker E, van der Most PJ, Verweij N, Vogel M, Wang H, Wang C, Wang N, Warren HR, Wen W, Wilsgaard T, Wong A, Wood AR, Xie T, Zafarmand MH, Zhao JH, Zhao W, Amin N, Arzumanyan Z, Astrup A, Bakker SJL, Baldassarre D, Beekman M, Bergman RN, Bertoni A, Blüher M, Bonnycastle LL, Bornstein SR, Bowden DW, Cai Q, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A, Du S, Eiriksdottir G, Farmaki AE, Frånberg M, Fuchsberger C, Gao Y, Gjesing AP, Goel A, Han S, Hartman CA, Herder C, Hicks AA, Hsieh CH, Hsueh WA, Ichihara S, Igase M, Ikram MA, Johnson WC, Jørgensen ME, Joshi PK, Kalyani RR, Kandeel FR, Katsuya T, Khor CC, Kiess W, Kolcic I, Kuulasmaa T, Kuusisto J, Läll K, Lam K, Lawlor DA, Lee NR, Lemaitre RN, Li H, Lin SY, Lindström J, Linneberg A, Liu J, Lorenzo C, Matsubara T, Matsuda F, Mingrone G, Mooijaart S, Moon S, Nabika T, Nadkarni GN, Nadler JL, Nelis M, Neville MJ, Norris JM, Ohyagi Y, Peters A, Peyser PA, Polasek O, Qi Q, Raven D, Reilly DF, Reiner A, Rivideneira F, Roll K, Rudan I, Sabanayagam C, Sandow K, Sattar N, Schürmann A, Shi J, Stringham HM, Taylor KD, Teslovich TM, Thuesen B, Timmers PRHJ, Tremoli E, Tsai MY, Uitterlinden A, van Dam RM, van Heemst D, van Hylckama Vlieg A, van Vliet-Ostaptchouk JV, Vangipurapu J, Vestergaard H, Wang T, Willems van Dijk K, Zemunik T, Abecasis GR, Adair LS, Aguilar-Salinas CA, Alarcón-Riquelme ME, An P, Aviles-Santa L, Becker DM, Beilin LJ, Bergmann S, Bisgaard H, Black C, Boehnke M, Boerwinkle E, Böhm BO, Bønnelykke K, Boomsma DI, Bottinger EP, Buchanan TA, Canouil M, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Cheng CY, Collins FS, Correa A, Cucca F, de Silva HJ, Dedoussis G, Elmståhl S, Evans MK, Ferrannini E, Ferrucci L, Florez JC, Franks PW, Frayling TM, Froguel P, Gigante B, Goodarzi MO, Gordon-Larsen P, Grallert H, Grarup N, Grimsgaard S, Groop L, Gudnason V, Guo X, Hamsten A, Hansen T, Hayward C, Heckbert SR, Horta BL, Huang W, Ingelsson E, James PS, Jarvelin MR, Jonas JB, Jukema JW, Kaleebu P, Kaplan R, Kardia SLR, Kato N, Keinanen-Kiukaanniemi SM, Kim BJ, Kivimaki M, Koistinen HA, Kooner JS, Körner A, Kovacs P, Kuh D, Kumari M, Kutalik Z, Laakso M, Lakka TA, Launer LJ, Leander K, Li H, Lin X, Lind L, Lindgren C, Liu S, Loos RJF, Magnusson PKE, Mahajan A, Metspalu A, Mook-Kanamori DO, Mori TA, Munroe PB, Njølstad I, O'Connell JR, Oldehinkel AJ, Ong KK, Padmanabhan S, Palmer CNA, Palmer ND, Pedersen O, Pennell CE, Porteous DJ, Pramstaller PP, Province MA, Psaty BM, Qi L, Raffel LJ, Rauramaa R, Redline S, Ridker PM, Rosendaal FR, Saaristo TE, Sandhu M, Saramies J, Schneiderman N, Schwarz P, Scott LJ, Selvin E, Sever P, Shu XO, Slagboom PE, Small KS, Smith BH, Snieder H, Sofer T, Sørensen TIA, Spector TD, Stanton A, Steves CJ, Stumvoll M, Sun L, Tabara Y, et al. The transView Related Profiles. PMID: 34059833; PMCID: PMC7610958; DOI: 10.1038/s41588-021-00852-9;
     
  9. Sanders JL, Putman RK, Dupuis J, Xu H, Murabito JM, Araki T, Nishino M, Benjamin EJ, Levy DL, Ramachandran VS, Washko GR, Curtis JL, Freeman CM, Bowler RP, Hatabu H, O'Connor GT, Hunninghake GM. The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. Am J Respir Crit Care Med. 2021 05 01; 203(9):1149-1157.View Related Profiles. PMID: 33080140; PMCID: PMC8314902; DOI: 10.1164/rccm.202007-2993OC;
     
  10. Georgakis MK, de Lemos JA, Ayers C, Wang B, Björkbacka H, Pana TA, Thorand B, Sun C, Fani L, Malik R, Dupuis J, Engström G, Orho-Melander M, Melander O, Boekholdt SM, Zierer A, Elhadad MA, Koenig W, Herder C, Hoogeveen RC, Kavousi M, Ballantyne CM, Peters A, Myint PK, Nilsson J, Benjamin EJ, Dichgans M. Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies. JAMA Cardiol. 2021 May 01; 6(5):587-592.View Related Profiles. PMID: 33146689; PMCID: PMC8111478; DOI: 10.1001/jamacardio.2020.5392;
     
Showing 10 of 282 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 282 publications over 27 distinct years, with a maximum of 22 publications in 2014 and 2015 and 2016

YearPublications
19952
19962
19972
19982
19993
20003
20013
20021
20032
20041
20056
20064
200718
200811
200914
201012
201113
201220
201311
201422
201522
201622
201720
201821
201918
202010
202117

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Statistical Genetics
Type-2 Diabetes
Machine Learning
Gene-Environment Interactions
Meta-Analysis

I am Professor and Chair of Biostatistics at the School of Public Health. I have been a mentor to over 35 students, post-doctoral and junior faculty trainees on research projects, and I have mentored many students, fellows and faculty in career development. I have also served as a mentor for the early-career faculty development program. I was fortunate to have outstanding and influential mentors throughout my career, and I strongly believe in "paying it forward" by providing the kind of mentoring that I was fortunate to receive.

My research expertise is statistical genetics, with special emphasis on the development and implementation of new statistical approaches for rare variant analysis, gene by environment evaluation and meta-analysis, with a focus on the analysis of family data. These new methods have been applied to multiple disease areas, such as type-2 diabetes and related traits, pulmonary functions and inflammation biomarkers, in order to elucidate the genetic architecture of these traits.

Available to Mentor as: (Review Mentor Role Definitions):
  • Career Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

801 Massachusetts Ave Crosstown Center
Boston MA 02118
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