Mohsan Saeed | Profiles RNS

Mohsan Saeed, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of Tokyo
DVM, University of Agriculture Faisalabad
MPhil, Quaid-i-azam Univ

Websites

	Biochemistry Faculty
	National Emerging Infectious Diseases Laboratories Faculty
	Google Scholar
	ResearchGate
	LinkedIn

ORCID : 0000-0001-8505-7054

My laboratory investigates the role that viral proteins, particularly viral proteases, play in remodeling host cells and creating a favorable environment for virus replication. To this end, we take a two-pronged approach: employ modern systems biology methods to get a global view of the virus-host interface and then use classical molecular biology and biochemistry techniques to gain deeper mechanistic insights.

The major focus of my laboratory is to identify and characterize host proteins that are cleaved by viral proteases. For this, we use a relatively unbiased approach to label and capture protein N-termini generated by proteolytic cleavage in virus-infected cells. This powerful proteomics (“degradomics”) approach not only identifies the cleaved proteins but also the site of cleavage within a protein. Once the proteins are identified and their cleavage is validated by orthogonal methods, we then ascertain the functional significance of these cleavages in the virus life cycle.

Besides studying host proteins that we have identified from the degradomics analysis of clinically important enteroviruses, we continue to extend this analysis to viruses from other families with the goal to get a global view of cellular pathways commonly targeted or co-opted by diverse viruses. These studies are expected to provide novel insights into cell biology, antiviral defenses, and disease mechanisms. Also, viral proteases are one of the prime targets for antiviral development, and therefore deeper insights into their function will help improve viral therapeutics.

Faculty
Boston University
National Emerging Infectious Disease Lab

Member
Boston University
Genome Science Institute

BU Research

Functional characterization of the enteroviral degradome
07/07/2022 - 06/30/2027 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI170877-03

Defining the role of site-specific proteolysis in innate defense signaling
07/01/2022 - 04/30/2027 (PI)
NIH/National Institute of General Medical Sciences
5R35GM147483-03

Investigating Interferon Antagonists in Delaying Innate Immune responses to SARS-CoV-2
07/09/2021 - 06/30/2026 (Subcontract PI)
Loyola University of Chicago NIH NIAID
4R01AI159945-03

Deciphering the Immune Evasion Mechanisms of Arboviruses in Mosquitoes
02/01/2024 - 01/31/2026 (PI)
The Smith Family Foundation

Deciphering the determinants of coronaviral tissue tropism
07/01/2023 - 06/30/2025 (PI)
American Lung Association

Development of DF-COV for the treatment and prevention of COVID-19 and associated immunopathologic respiratory complications
01/15/2021 - 01/14/2025 (Multi PI of Sub-Project / SP)
Dana-Farber Cancer Institute DOD Army Med Resrch

Probing Pathomechanisms of Enterovirus D68 Infection
03/01/2020 - 03/31/2023 (PI)
Charles H. Hood Foundation

Mapping Pathogenic Coronavirus Viral-Host Protein Interaction Environments for Target Discovery
08/03/2020 - 01/02/2022 (Multi-PI)
PI: Mohsan Saeed, PhD
Merck, Sharp & Dohme LLC

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA. Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Res. 2024 Aug 06; 230:105976.View Related Profiles.

Wacquiez, Alan Cyril Jacques
Porco, John
Connor, John
Brown, Lauren
Ricca, Michael
Saeed, Mohsan
Davey, Robert
Lyons, Shawn

PMID: 39117283

Ackermann-Gäumann R, Dentand A, Lienhard R, Saeed M, Speiser DE, MacDonald MR, Coste AT, Cagno V. A reporter virus particle seroneutralization assay for tick-borne encephalitis virus overcomes ELISA limitations. J Med Virol. 2024 Aug; 96(8):e29843. PMID: 39092814

Caobi A, Saeed M. Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern. Curr Opin Microbiol. 2024 Jun; 79:102454.View Related Profiles.

Caobi, Allen
Saeed, Mohsan

PMID: 38518551; PMCID: PMC11162932; DOI: 10.1016/j.mib.2024.102454;

Weingarten-Gabbay S, Chen DY, Sarkizova S, Taylor HB, Gentili M, Hernandez GM, Pearlman LR, Bauer MR, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. The HLA-II immunopeptidome of SARS-CoV-2. Cell Rep. 2024 Jan 23; 43(1):113596. PMID: 38117652; PMCID: PMC10860710; DOI: 10.1016/j.celrep.2023.113596;

Lin L, Chen DY, Scartelli C, Xie H, Merrill-Skoloff G, Yang M, Sun L, Saeed M, Flaumenhaft R. Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication. iScience. 2023 Sep 15; 26(9):107602. PMID: 37664626; PMCID: PMC10470319; DOI: 10.1016/j.isci.2023.107602;

Datta S, Chen DY, Tavares AH, Reyes-Robles T, Ryu KA, Khan N, Bechtel TJ, Bertoch JM, White CH, Hazuda DJ, Vora KA, Hett EC, Fadeyi OO, Oslund RC, Emili A, Saeed M. High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface. Cell Chem Biol. 2023 Oct 19; 30(10):1313-1322.e7.View Related Profiles.

Saeed, Mohsan
Khan, Nazimuddin
Datta, Suprama

PMID: 37499664

Feng S, O'Brien A, Chen DY, Saeed M, Baker SC. SARS-CoV-2 nonstructural protein 6 from Alpha to Omicron: evolution of a transmembrane protein. mBio. 2023 Aug 31; 14(4):e0068823. PMID: 37477426; PMCID: PMC10470488; DOI: 10.1128/mbio.00688-23;

Weingarten-Gabbay S, Chen DY, Sarkizova S, Taylor HB, Gentili M, Pearlman LR, Bauer MR, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. The HLA-II immunopeptidome of SARS-CoV-2. bioRxiv. 2023 Jun 01. PMID: 37398281; PMCID: PMC10312465; DOI: 10.1101/2023.05.26.542482;

Yang L, Han Y, Zhou T, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C, Giani AM, Li Y, Dong X, Moroziewicz D, Paull D, Chen Z, Zhong A, Noggle SA, Rice CM, Qi Q, Evans T, Chen S. Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience. 2023 Jul 21; 26(7):107001. PMID: 37534130; PMCID: PMC10391681; DOI: 10.1016/j.isci.2023.107001;

Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. iScience. 2023 May 19; 26(5):106634.View Related Profiles.

Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Seitz, Scott
Kapell, Sebastian

PMID: 37095858; PMCID: PMC10083141; DOI: 10.1016/j.isci.2023.106634;

Showing 10 of 65 results. Show More

Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation. Nature. 2023 Mar; 615(7950):143-150.View Related Profiles.

Kotton, Darrell
Douam, Florian
Connor, John
Bosmann, Markus
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Kataria, Yachana

PMID: 36630998

Chen DY, Kenney D, Chin CV, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron. bioRxiv. 2023 Jan 10.View Related Profiles.

Kotton, Darrell
Douam, Florian
Connor, John
Bosmann, Markus
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Kataria, Yachana

PMID: 36263066; PMCID: PMC9580375; DOI: 10.1101/2022.10.13.512134;

Weingarten-Gabbay S, Pearlman LR, Chen DY, Klaeger S, Taylor HB, Welch NL, Keskin DB, Carr SA, Abelin JG, Saeed M, Sabeti PC. HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses. STAR Protoc. 2022 Dec 16; 3(4):101910. PMID: 36595954; PMCID: PMC9731565; DOI: 10.1016/j.xpro.2022.101910;

Torchia JA, Tavares AH, Carstensen LS, Chen DY, Huang J, Xiao T, Mukherjee S, Reeves PM, Tu H, Sluder AE, Chen B, Kotton DN, Bowen RA, Saeed M, Poznansky MC, Freeman GJ. Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. Sci Adv. 2022 Dec 09; 8(49):eabq6527.View Related Profiles.

Kotton, Darrell
Saeed, Mohsan

PMID: 36475798; PMCID: PMC9728973; DOI: 10.1126/sciadv.abq6527;

Han Y, Tan L, Zhou T, Yang L, Carrau L, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022 Oct 06; 29(10):1475-1490.e6. PMID: 36206731; PMCID: PMC9550219; DOI: 10.1016/j.stem.2022.09.008;

Chin CV, Saeed M. Surgical Strikes on Host Defenses: Role of the Viral Protease Activity in Innate Immune Antagonism. Pathogens. 2022 Apr 28; 11(5).View Related Profiles.

Chin, Chue Vin
Saeed, Mohsan

PMID: 35631043; PMCID: PMC9145062; DOI: 10.3390/pathogens11050522;

Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022 Apr 19; 39(3):110714.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Huber, Bertrand
Bullitt, Esther
Douam, Florian
Connor, John
Campbell, Joshua
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas

PMID: 35421379; PMCID: PMC8977517; DOI: 10.1016/j.celrep.2022.110714;

Serganov AA, Udi Y, Stein ME, Patel V, Fridy PC, Rice CM, Saeed M, Jacobs EY, Chait BT, Rout MP. Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease. J Biol Chem. 2022 Jun; 298(6):101882. PMID: 35367208; PMCID: PMC9168619; DOI: 10.1016/j.jbc.2022.101882;

Carossino M, Kenney D, O'Connell AK, Montanaro P, Tseng AE, Gertje HP, Grosz KA, Ericsson M, Huber BR, Kurnick SA, Subramaniam S, Kirkland TA, Walker JR, Francis KP, Klose AD, Paragas N, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression. Viruses. 2022 03 05; 14(3).View Related Profiles.

Huber, Bertrand
Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas
Subramaniam, Saravanan

PMID: 35336942; PMCID: PMC8955233; DOI: 10.3390/v14030535;

Ren W, Zhu Y, Lan J, Chen H, Wang Y, Shi H, Feng F, Chen DY, Close B, Zhao X, Wu J, Tian B, Yuan Z, Zhou D, Saeed M, Wang X, Zhang R, Ding Q. Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection. J Virol. 2022 01 12; 96(1):e0149221. PMID: 34668773; PMCID: PMC8754202; DOI: 10.1128/JVI.01492-21;

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021 09 09; 95(19):e0086221.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Chen, Christopher
Kotton, Darrell
Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Goel, Raghuveera
Chitalia, Vipul

PMID: 34260266; PMCID: PMC8428404; DOI: 10.1128/JVI.00862-21;

Nageswara Rao D, Zephyr J, Henes M, Chan ET, Matthew AN, Hedger AK, Conway HL, Saeed M, Newton A, Petropoulos CJ, Huang W, Kurt Yilmaz N, Schiffer CA, Ali A. Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants. J Med Chem. 2021 08 26; 64(16):11972-11989. PMID: 34405680; PMCID: PMC9228641; DOI: 10.1021/acs.jmedchem.1c00554;

Kim S, Yee E, Miller EA, Hao Y, Tay DMY, Sung KJ, Jia H, Johnson JM, Saeed M, Mace CR, Yüksel Yurt D, Sikes HD. Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins. ACS Appl Mater Interfaces. 2021 Aug 25; 13(33):38990-39002. PMID: 34379400

Bandyopadhyay S, Douglass J, Kapell S, Khan N, Feitosa-Suntheimer F, Klein JA, Temple J, Brown-Culbertson J, Tavares AH, Saeed M, Lau NC. DNA templates with blocked long 3' end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci. G3 (Bethesda). 2021 08 07; 11(8).View Related Profiles.

Klein, Jenny
Saeed, Mohsan
Khan, Nazimuddin
Lau, Nelson
Bandyopadhyay, Saptaparni
Kapell, Sebastian

PMID: 33989385; PMCID: PMC8496256; DOI: 10.1093/g3journal/jkab169;

Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Gallagher KME, Bauer MR, Taylor HB, Dunn WA, Tarr C, Sidney J, Rachimi S, Conway HL, Katsis K, Wang Y, Leistritz-Edwards D, Durkin MR, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Carulli IP, Chea VA, Chandrashekar A, Bozkus CC, Carrington M, Bhardwaj N, Barouch DH, Sette A, Maus MV, Rice CM, Clauser KR, Keskin DB, Pregibon DC, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs. Cell. 2021 07 22; 184(15):3962-3980.e17. PMID: 34171305; PMCID: PMC8173604; DOI: 10.1016/j.cell.2021.05.046;

Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T, Tavares AH, Saeed M, Holehouse AS, Ploss A, Levental I, Douam F, Padera RF, Levy BD, Brangwynne CP. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. Elife. 2021 04 23; 10.View Related Profiles.

Douam, Florian
Saeed, Mohsan

PMID: 33890572; PMCID: PMC8104966; DOI: 10.7554/eLife.65962;

Kim S, Yee EH, Miller EA, Hao Y, Tay DMY, Sung KJ, Jia H, Johnson JM, Saeed M, Mace CR, Yurt DY, Sikes H. Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins. ChemRxiv. 2021 Apr 19. PMID: 34013166; PMCID: PMC8132241; DOI: 10.26434/chemrxiv.14442785;

Loffredo M, Lucero H, Chen DY, O'Connell A, Bergqvist S, Munawar A, Bandara A, De Graef S, Weeks SD, Douam F, Saeed M, Munawar AH. The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication. Sci Rep. 2021 03 08; 11(1):5433.View Related Profiles.

Douam, Florian
Saeed, Mohsan

PMID: 33686143; PMCID: PMC7940615; DOI: 10.1038/s41598-021-84782-w;

O'Brien A, Chen DY, Hackbart M, Close BJ, O'Brien TE, Saeed M, Baker SC. Detecting SARS-CoV-2 3CLpro expression and activity using a polyclonal antiserum and a luciferase-based biosensor. Virology. 2021 04; 556:73-78. PMID: 33548599; PMCID: PMC7837110; DOI: 10.1016/j.virol.2021.01.010;

Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz KA, Kurnick SA, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. bioRxiv. 2021 Jan 15.View Related Profiles.

Huber, Bertrand
Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas
Subramaniam, Saravanan

PMID: 33469581; PMCID: PMC7814818; DOI: 10.1101/2021.01.13.425144;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;

Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T. Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Sci Adv. 2020 11; 6(45). PMID: 33148654; PMCID: PMC7673688; DOI: 10.1126/sciadv.abd3233;

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Chen, Christopher
Kotton, Darrell
Douam, Florian
Connor, John
Saeed, Mohsan
Khan, Nazimuddin
Crossland, Nicholas
Goel, Raghuveera
Kapell, Sebastian
Chitalia, Vipul

PMID: 33140044; PMCID: PMC7605551; DOI: 10.1101/2020.10.27.358259;

Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Bauer MR, Taylor HB, Conway HL, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Keskin DB, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs. bioRxiv. 2020 Oct 02. PMID: 33024965; PMCID: PMC7536868; DOI: 10.1101/2020.10.02.324145;

Saeed M, Kapell S, Hertz NT, Wu X, Bell K, Ashbrook AW, Mark MT, Zebroski HA, Neal ML, Flodström-Tullberg M, MacDonald MR, Aitchison JD, Molina H, Rice CM. Defining the proteolytic landscape during enterovirus infection. PLoS Pathog. 2020 09; 16(9):e1008927.View Related Profiles.

Saeed, Mohsan
Kapell, Sebastian

PMID: 32997711; PMCID: PMC7549765; DOI: 10.1371/journal.ppat.1008927;

Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Lindstrom-Vautrin J, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020 12 03; 27(6):962-973.e7.View Related Profiles.

Hume, Adam
Wilson, Andrew
Kotton, Darrell
Muhlberger, Elke
Burks, Eric
Bullitt, Esther
Hawkins, Finn
Huang, Jessie
Olejnik, Judith
Bosmann, Markus
Saeed, Mohsan
Werder, Rhiannon Bree

PMID: 32979316; PMCID: PMC7500949; DOI: 10.1016/j.stem.2020.09.013;

Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction. Nat Commun. 2020 08 21; 11(1):4198. PMID: 32826914; PMCID: PMC7442812; DOI: 10.1038/s41467-020-18058-8;

Pfaender S, Mar KB, Michailidis E, Kratzel A, Boys IN, V'kovski P, Fan W, Kelly JN, Hirt D, Ebert N, Stalder H, Kleine-Weber H, Hoffmann M, Hoffmann HH, Saeed M, Dijkman R, Steinmann E, Wight-Carter M, McDougal MB, Hanners NW, Pöhlmann S, Gallagher T, Todt D, Zimmer G, Rice CM, Schoggins JW, Thiel V. LY6E impairs coronavirus fusion and confers immune control of viral disease. Nat Microbiol. 2020 11; 5(11):1330-1339. PMID: 32704094; PMCID: PMC7916999; DOI: 10.1038/s41564-020-0769-y;

Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles.

Hume, Adam
Wilson, Andrew
Kotton, Darrell
Muhlberger, Elke
Burks, Eric
Bullitt, Esther
Hawkins, Finn
Olejnik, Judith
Bosmann, Markus
Saeed, Mohsan
Werder, Rhiannon Bree

PMID: 32637964; PMCID: PMC7337394; DOI: 10.1101/2020.06.30.175695;

Ejemel M, Li Q, Hou S, Schiller ZA, Wallace AL, Amcheslavsky A, Yilmaz NK, Toomey JR, Schneider R, Close BJ, Chen DY, Conway HL, Mohsan S, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity. bioRxiv. 2020 May 15. PMID: 32511396; PMCID: PMC7263543; DOI: 10.1101/2020.05.15.096719;

Esswein SR, Gristick HB, Jurado A, Peace A, Keeffe JR, Lee YE, Voll AV, Saeed M, Nussenzweig MC, Rice CM, Robbiani DF, MacDonald MR, Bjorkman PJ. Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9865-9875. PMID: 32321830; PMCID: PMC7211955; DOI: 10.1073/pnas.1919269117;

Dao Thi VL, Wu X, Belote RL, Andreo U, Takacs CN, Fernandez JP, Vale-Silva LA, Prallet S, Decker CC, Fu RM, Qu B, Uryu K, Molina H, Saeed M, Steinmann E, Urban S, Singaraja RR, Schneider WM, Simon SM, Rice CM. Stem cell-derived polarized hepatocytes. Nat Commun. 2020 04 03; 11(1):1677. PMID: 32245952; PMCID: PMC7125181; DOI: 10.1038/s41467-020-15337-2;

Pfaender S, Mar KB, Michailidis E, Kratzel A, Hirt D, V'kovski P, Fan W, Ebert N, Stalder H, Kleine-Weber H, Hoffmann M, Hoffmann HH, Saeed M, Dijkman R, Steinmann E, Wight-Carter M, Hanners NW, Pöhlmann S, Gallagher T, Todt D, Zimmer G, Rice CM, Schoggins JW, Thiel V. LY6E impairs coronavirus fusion and confers immune control of viral disease. bioRxiv. 2020 Mar 07. PMID: 32511345; PMCID: PMC7255780; DOI: 10.1101/2020.03.05.979260;

Liu D, Tedbury PR, Lan S, Huber AD, Puray-Chavez MN, Ji J, Michailidis E, Saeed M, Ndongwe TP, Bassit LC, Schinazi RF, Ralston R, Rice CM, Sarafianos SG. Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus. Viruses. 2019 11 08; 11(11). PMID: 31717338; PMCID: PMC6893808; DOI: 10.3390/v11111039;

Luna JM, Saeed M, Rice CM. Taming a beast: lessons from the domestication of hepatitis C virus. Curr Opin Virol. 2019 04; 35:27-34. PMID: 30875640; PMCID: PMC6556422; DOI: 10.1016/j.coviro.2019.02.008;

Rusanov T, Kent T, Saeed M, Hoang TM, Thomas C, Rice CM, Pomerantz RT. Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication. Sci Rep. 2018 11 26; 8(1):17384. PMID: 30478404; PMCID: PMC6255901; DOI: 10.1038/s41598-018-35511-3;

Keeffe JR, Van Rompay KKA, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC, Robbiani DF. A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates. Cell Rep. 2018 11 06; 25(6):1385-1394.e7. PMID: 30403995; PMCID: PMC6268006; DOI: 10.1016/j.celrep.2018.10.031;

Kuchay S, Saeed M, Giorgi C, Li J, Hoffmann HH, Pinton P, Rice CM, Pagano M. NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. Cell Rep. 2018 10 23; 25(4):833-840.e3. PMID: 30355490; PMCID: PMC6247906; DOI: 10.1016/j.celrep.2018.09.088;

Robinson CL, Chong ACN, Ashbrook AW, Jeng G, Jin J, Chen H, Tang EI, Martin LA, Kim RS, Kenyon RM, Do E, Luna JM, Saeed M, Zeltser L, Ralph H, Dudley VL, Goldstein M, Rice CM, Cheng CY, Seandel M, Chen S. Male germ cells support long-term propagation of Zika virus. Nat Commun. 2018 05 29; 9(1):2090. PMID: 29844387; PMCID: PMC5974187; DOI: 10.1038/s41467-018-04444-w;

Robbiani DF, Bozzacco L, Keeffe JR, Khouri R, Olsen PC, Gazumyan A, Schaefer-Babajew D, Avila-Rios S, Nogueira L, Patel R, Azzopardi SA, Uhl LFK, Saeed M, Sevilla-Reyes EE, Agudelo M, Yao KH, Golijanin J, Gristick HB, Lee YE, Hurley A, Caskey M, Pai J, Oliveira T, Wunder EA, Sacramento G, Nery N, Orge C, Costa F, Reis MG, Thomas NM, Eisenreich T, Weinberger DM, de Almeida ARP, West AP, Rice CM, Bjorkman PJ, Reyes-Teran G, Ko AI, MacDonald MR, Nussenzweig MC. Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell. 2017 May 04; 169(4):597-609.e11. PMID: 28475892; PMCID: PMC5492969; DOI: 10.1016/j.cell.2017.04.024;

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Florian WR, De Francesco R, Rice CM, Bartenschlager R, Lohmann V. Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. Nat Microbiol. 2017 Jan 23; 2:17012. PMID: 28112725

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V. Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. Nat Microbiol. 2016 12 19; 2:16247. PMID: 27991882; DOI: 10.1038/nmicrobiol.2016.247;

Saeed M, Andreo U, Chung HY, Espiritu C, Branch AD, Silva JM, Rice CM. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature. 2015 Aug 27; 524(7566):471-5. PMID: 26266980; PMCID: PMC4632207; DOI: 10.1038/nature14899;

Stoddard MB, Li H, Wang S, Saeed M, Andrus L, Ding W, Jiang X, Learn GH, von Schaewen M, Wen J, Goepfert PA, Hahn BH, Ploss A, Rice CM, Shaw GM. Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4. MBio. 2015 Feb 24; 6(2):e02518. PMID: 25714714; PMCID: PMC4358020; DOI: 10.1128/mBio.02518-14;

Wose Kinge CN, Espiritu C, Prabdial-Sing N, Sithebe NP, Saeed M, Rice CM. Hepatitis C virus genotype 5a subgenomic replicons for evaluation of direct-acting antiviral agents. Antimicrob Agents Chemother. 2014 Sep; 58(9):5386-94. PMID: 24982066; PMCID: PMC4135880; DOI: 10.1128/AAC.03534-14;

Rice CM, Saeed M. Hepatitis C: Treatment triumphs. Nature. 2014 Jun 05; 510(7503):43-4. PMID: 24899301; DOI: 10.1038/510043a;

Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2014 Jan; 20(1):47-53. PMID: 24362933; PMCID: PMC4096771; DOI: 10.1038/nm.3424;

Saeed M, Gondeau C, Hmwe S, Yokokawa H, Date T, Suzuki T, Kato T, Maurel P, Wakita T. Replication of hepatitis C virus genotype 3a in cultured cells. Gastroenterology. 2013 Jan; 144(1):56-58.e7. PMID: 22999961; DOI: 10.1053/j.gastro.2012.09.017;

Saeed M, Scheel TK, Gottwein JM, Marukian S, Dustin LB, Bukh J, Rice CM. Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells. Antimicrob Agents Chemother. 2012 Oct; 56(10):5365-73. PMID: 22869572; PMCID: PMC3457365; DOI: 10.1128/AAC.01256-12;

Saeed M, Suzuki R, Watanabe N, Masaki T, Tomonaga M, Muhammad A, Kato T, Matsuura Y, Watanabe H, Wakita T, Suzuki T. Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles. J Biol Chem. 2011 Oct 28; 286(43):37264-73. PMID: 21878646; PMCID: PMC3199473; DOI: 10.1074/jbc.M111.259085;

Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T. In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis. Hepatology. 2011 Aug; 54(2):425-33. PMID: 21538444; PMCID: PMC3145027; DOI: 10.1002/hep.24399;

Masaki T, Suzuki R, Saeed M, Mori K, Matsuda M, Aizaki H, Ishii K, Maki N, Miyamura T, Matsuura Y, Wakita T, Suzuki T. Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription. J Virol. 2010 Jun; 84(11):5824-35. PMID: 20237083; PMCID: PMC2876618; DOI: 10.1128/JVI.02397-09;

Saeed M, Suzuki R, Kondo M, Aizaki H, Kato T, Mizuochi T, Wakita T, Watanabe H, Suzuki T. Evaluation of hepatitis C virus core antigen assays in detecting recombinant viral antigens of various genotypes. J Clin Microbiol. 2009 Dec; 47(12):4141-3. PMID: 19812276; PMCID: PMC2786616; DOI: 10.1128/JCM.01437-09;

Saeed M, Zaidi SZ, Naeem A, Masroor M, Sharif S, Shaukat S, Angez M, Khan A. Epidemiology and clinical findings associated with enteroviral acute flaccid paralysis in Pakistan. BMC Infect Dis. 2007 Feb 15; 7:6. PMID: 17300736; PMCID: PMC1804272; DOI: 10.1186/1471-2334-7-6;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 65 publications over 17 distinct years, with a maximum of 13 publications in 2020

Bar chart showing 65 publications over 17 distinct years, with a maximum of 13 publications in 2020

Year	Publications
2007	1
2009	1
2010	1
2011	2
2012	2
2013	1
2014	2
2015	2
2016	1
2017	2
2018	4
2019	2
2020	13
2021	12
2022	7
2023	9
2024	3

Media Mentions
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South End Resident Honored with Smith Family Foundation Odyssey Award

My South End 11/16/2023

American Lung Association Funds $13.6 Million in Research for a Future Free of Lung Disease

BioSpace 10/12/2023

BU researchers discover a mutation that may be weakening COVID

WBUR 1/12/2023

NEIDL Researchers Discover New SARS-CoV-2 Weak Spot—Which Could Inspire Improved Vaccines

The Brink 1/11/2023

Coronavirus ‘chimera’ made in lab shows what makes omicron seemingly less deadly

The Washington Post 1/11/2023

Best of The Brink 2022: BU’s Most-Read Science and Research Stories

BU Today 12/13/2022

BU to Require Boosters, Will Stop Daily Attestation Requirement

BU Today 12/13/2021

Researchers identify coronavirus proteins that could make new, more powerful vaccines

The Hill 6/23/2021

New ‘Recipe’ Could Lead To Better COVID-19 Vaccines

Futurity 6/15/2021

Study Reveals Recipe for Even More Powerful COVID-19 Vaccines

BU Today 6/11/2021

Is there a limit to how much the coronavirus can mutate?

Live Science 2/11/2021

What Sets Off Deadly Levels of Lung Inflammation in Some COVID-19 Patients?

BU Today 9/8/2020

A popular heartburn medicine doesn’t work as a COVID-19 antiviral

Science News 7/27/2020

BU Scientists Awarded $1.9 Million to Accelerate Coronavirus Research

BU Today 5/13/2020

BU Labs, Researchers and Students Fight COVID-19

The Daily Free Press 4/29/2020

BU Labs Exploring COVID-19 Vaccines

The Daily Free Press 3/17/2020

Coronavirus Declared a Pandemic, Cases in U.S. and Massachusetts Continue to Rise

The Boston Herald: 3/11/2020

COVID-19: What You Should And Shouldn’t Do Now

Futurity 3/4/2020

Coronavirus Is Coming: Dos and Don’ts for Protecting Yourself

BU Today 2/27/2020

Update: Latest BU News on Coronavirus

BU Today 2/3/2020

BU Postpones Shanghai Study Abroad Program Amid Coronavirus Fears

BU Today 1/30/2020

Coronavirus Outbreak Resembles SARS, But Virus Experts Say Science Moves Far Faster Now

WBUR 1/29/2020

Outbreak Experts: What to Expect Next from Coronavirus

BU Today 1/27/2020

BU Closely Monitoring Coronavirus Outbreak

BU Today 1/22/2020

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