Ralph D'Agostino, PhD
Professor
Boston University Graduate School of Arts and Sciences
Dept of Mathematics and Statistics

PhD, Harvard University
AM, Boston University



Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Professor
Boston University School of Public Health
Biostatistics


Professor
Boston University School of Public Health
Epidemiology


Co-Director
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit


2008 US Food and Drug Administration: Advisory Committee Service Award
2006 Remington Lecturer for Cardiovascular Epidemiology Section of the American Heart Association meeting
1997 Massachusetts Health Data Consortium, Inc: Investing in Information Award at HealthMart '97
1996 Lowell Reed Lecturer at the American Public Health Association Meeting, November Meeting
1995 University of Wisconsin: Rankin Visiting Professor in Epidemiology and Preventive Medicine
1995 Federal Food and Drug Administration: Commissioner's Special Citation
1993 Boston Chapter American Statistical Association: Statistician of the Year
1985 Boston University: Metcalf Cup and Prize for Excellence in Teaching
1981 Federal Food and Drug Administration: Commissioner's Special Citation
1974 Boston University College of Liberal Arts: Distinguished Alumni
1965-1968 National Institutes of Health Predoctoral Fellow


OPTIMIZING CARDIOVASCULAR RISK PREDICTION IN HIV
12/15/2016 - 11/30/2020 (PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL132786-02

PROMETRIKA, LLC: STATISTICAL RESEARCH IN CLINICAL TRIALS - BAIYUN YAO
09/04/2012 - 04/28/2013 (Co-PI)
PI: Joseph Massaro, PhD
Prometrika, Inc.

Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Pencina MJ, Steyerberg EW, D'Agostino RB. Single-number summary and decision analytic measures can happily coexist. Stat Med. 2019 Feb 10; 38(3):499-500.View Related Profiles. PMID: 30609149.
     
  2. Selker HP, Eichler HG, Stockbridge NL, McElwee NE, Dere WH, Cohen T, Erban JK, Seyfert-Margolis VL, Honig PK, Kaitin KI, Oye KA, D'Agostino RB. Efficacy and Effectiveness Too (EE2) Trials:Clinical Trial Designs to Generate Evidence on Efficacy and on Effectiveness in Wide Practice. Clin Pharmacol Ther. 2019 Jan 04. PMID: 30610746.
     
  3. Mosepele M, Regan S, Massaro J, Meigs JB, Zanni MV, D'Agostino RB, Grinspoon SK, Triant VA. Impact of the American College of Cardiology/American Heart Association Cholesterol Guidelines on Statin Eligibility Among Human Immunodeficiency Virus-Infected Individuals. Open Forum Infect Dis. 2018 Dec; 5(12):ofy326.View Related Profiles. PMID: 30619912; DOI: 10.1093/ofid/ofy326;.
     
  4. Pencina MJ, Navar AM, Wojdyla D, Sanchez RJ, Khan I, Elassal J, D'Agostino RB, Peterson ED, Sniderman AD. Quantifying Importance of Major Risk Factors for Coronary Heart Disease. Circulation. 2018 Dec 07.View Related Profiles. PMID: 30586759.
     
  5. Schoppa I, Lyass A, Heard-Costa N, de Ferranti SD, Fox C, Gillman MW, D'Agostino R, Levy D, Mendelson MM. Association of Maternal Prepregnancy Weight with Offspring Adiposity Throughout Adulthood over 37 Years of Follow-up. Obesity (Silver Spring). 2019 Jan; 27(1):137-144.View Related Profiles. PMID: 30474203.
     
  6. Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, Moons KGM, van der Schouw YT, Selmer R, Khaw KT, Gudnason V, Assmann G, Amouyel P, Salomaa V, Kivimaki M, Nordestgaard BG, Blaha MJ, Kuller LH, Brenner H, Gillum RF, Meisinger C, Ford I, Knuiman MW, Rosengren A, Lawlor DA, Völzke H, Cooper C, Marín Ibañez A, Casiglia E, Kauhanen J, Cooper JA, Rodriguez B, Sundström J, Barrett-Connor E, Dankner R, Nietert PJ, Davidson KW, Wallace RB, Blazer DG, Björkelund C, Donfrancesco C, Krumholz HM, Nissinen A, Davis BR, Coady S, Whincup PH, Jørgensen T, Ducimetiere P, Trevisan M, Engström G, Crespo CJ, Meade TW, Visser M, Kromhout D, Kiechl S, Daimon M, Price JF, Gómez de la Cámara A, Wouter Jukema J, Lamarche B, Onat A, Simons LA, Kavousi M, Ben-Shlomo Y, Gallacher J, Dekker JM, Arima H, Shara N, Tipping RW, Roussel R, Brunner EJ, Koenig W, Sakurai M, Pavlovic J, Gansevoort RT, Nagel D, Goldbourt U, Barr ELM, Palmieri L, Njølstad I, Sato S, Monique Verschuren WM, Varghese CV, Graham I, Onuma O, Greenland P, Woodward M, Ezzati M, Psaty BM, Sattar N, Jackson R, Ridker PM, Cook NR, D'Agostino RB, Thompson SG, Danesh J, Di Angelantonio E. Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. Eur Heart J. 2018 Nov 22. PMID: 30476079.
     
  7. Hernandez AF, Green JB, Janmohamed S, D'Agostino RB, Granger CB, Jones NP, Leiter LA, Rosenberg AE, Sigmon KN, Somerville MC, Thorpe KM, McMurray JJV, Del Prato S. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. Lancet. 2018 10 27; 392(10157):1519-1529. PMID: 30291013.
     
  8. Pencina KM, D'Agostino RB, Vasan RS, Pencina MJ. Microsimulation model to predict incremental value of biomarkers added to prognostic models. J Am Med Inform Assoc. 2018 Oct 01; 25(10):1382-1385.View Related Profiles. PMID: 30169699.
     
  9. Ibrahim NE, Gupta R, Lyass A, Li Y, Shrestha S, McCarthy CP, Gaggin HK, van Kimmenade RRJ, Massaro JM, D'Agostino RB, Januzzi JL. Endothelin-1 Measurement in Patients Undergoing Diagnostic Coronary Angiography-Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study. Clin Chem. 2018 Nov; 64(11):1617-1625.View Related Profiles. PMID: 30213784.
     
  10. Kaasenbrood L, Bhatt DL, Dorresteijn JAN, Wilson PWF, D'Agostino RB, Massaro JM, van der Graaf Y, Cramer MJM, Kappelle LJ, de Borst GJ, Steg PG, Visseren FLJ. Estimated Life Expectancy Without Recurrent Cardiovascular Events in Patients With Vascular Disease: The SMART-REACH Model. J Am Heart Assoc. 2018 Aug 21; 7(16):e009217.View Related Profiles. PMID: 30369323.
     
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