Ralph D'Agostino, PhD
Professor
Boston University Graduate School of Arts and Sciences
Dept of Mathematics and Statistics

PhD, Harvard University
AM, Boston University



Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Professor
Boston University School of Public Health
Biostatistics


Professor
Boston University School of Public Health
Epidemiology


Co-Director
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit


2008 US Food and Drug Administration: Advisory Committee Service Award
2006 Remington Lecturer for Cardiovascular Epidemiology Section of the American Heart Association meeting
1997 Massachusetts Health Data Consortium, Inc: Investing in Information Award at HealthMart '97
1996 Lowell Reed Lecturer at the American Public Health Association Meeting, November Meeting
1995 University of Wisconsin: Rankin Visiting Professor in Epidemiology and Preventive Medicine
1995 Federal Food and Drug Administration: Commissioner's Special Citation
1993 Boston Chapter American Statistical Association: Statistician of the Year
1985 Boston University: Metcalf Cup and Prize for Excellence in Teaching
1981 Federal Food and Drug Administration: Commissioner's Special Citation
1974 Boston University College of Liberal Arts: Distinguished Alumni
1965-1968 National Institutes of Health Predoctoral Fellow


OPTIMIZING CARDIOVASCULAR RISK PREDICTION IN HIV
12/15/2016 - 11/30/2020 (PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL132786-02

PROMETRIKA, LLC: STATISTICAL RESEARCH IN CLINICAL TRIALS - BAIYUN YAO
09/04/2012 - 04/28/2013 (Co-PI)
PI: Joseph Massaro, PhD
Prometrika, Inc.

Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Hernandez AF, Green JB, Janmohamed S, D'Agostino RB, Granger CB, Jones NP, Leiter LA, Rosenberg AE, Sigmon KN, Somerville MC, Thorpe KM, McMurray JJV, Del Prato S. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. Lancet. 2018 Oct 01. PMID: 30291013.
     
  2. Meléndez GC, Jordan JH, D'Agostino RB, Lesnefsky EJ, Hundley WG. Accelerated Left Ventricular Interstitial Collagen Deposition After Receiving Doxorubicin in Hypertension. J Am Coll Cardiol. 2018 Sep 25; 72(13):1555-1557. PMID: 30236317.
     
  3. Ibrahim NE, Gupta R, Lyass A, Li Y, Shrestha S, McCarthy CP, Gaggin HK, van Kimmenade RRJ, Massaro JM, D'Agostino RB, Januzzi JL. Endothelin-1 Measurement in Patients Undergoing Diagnostic Coronary Angiography-Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study. Clin Chem. 2018 Sep 13.View Related Profiles. PMID: 30213784.
     
  4. Pencina KM, D'Agostino RB, Vasan RS, Pencina MJ. Microsimulation model to predict incremental value of biomarkers added to prognostic models. J Am Med Inform Assoc. 2018 Aug 28.View Related Profiles. PMID: 30169699.
     
  5. Pencina MJ, Rockhold FW, D'Agostino RB. Deriving Real-World Insights From Real-World Data: Biostatistics to the Rescue. Ann Intern Med. 2018 Sep 18; 169(6):401-402.View Related Profiles. PMID: 30039173.
     
  6. Mok Y, Ballew SH, Bash LD, Bhatt DL, Boden WE, Bonaca MP, Carrero JJ, Coresh J, D'Agostino RB, Elley CR, Fowkes FGR, Jee SH, Kovesdy CP, Mahaffey KW, Nadkarni G, Peterson ED, Sang Y, Matsushita K. International Validation of the Thrombolysis in Myocardial Infarction (TIMI) Risk Score for Secondary Prevention in Post-MI Patients: A Collaborative Analysis of the Chronic Kidney Disease Prognosis Consortium and the Risk Validation Scientific Committee. J Am Heart Assoc. 2018 Jul 07; 7(14).View Related Profiles. PMID: 29982232.
     
  7. Thomas LE, O'Brien EC, Piccini JP, D'Agostino RB, Pencina MJ. Application of net reclassification index to non-nested and point-based risk prediction models: a review. Eur Heart J. 2018 Jun 27.View Related Profiles. PMID: 29955849.
     
  8. Wallner LP, DiBello JR, Li BH, Van Den Eeden SK, Weinmann S, Ritzwoller DP, Abell JE, D'Agostino R, Loo RK, Aaronson DS, Horwitz RI, Jacobsen SJ. The Use of 5-Alpha Reductase Inhibitors to Manage Benign Prostatic Hyperplasia and the Risk of All-cause Mortality. Urology. 2018 Sep; 119:70-78. PMID: 29906480.
     
  9. Green JB, Hernandez AF, D'Agostino RB, Granger CB, Janmohamed S, Jones NP, Leiter LA, Noronha D, Russell R, Sigmon K, Del Prato S, McMurray JJV. Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus-Rationale, design, and baseline characteristics. Am Heart J. 2018 Sep; 203:30-38. PMID: 30015066.
     
  10. Dmitrienko A, D'Agostino RB. Multiplicity Considerations in Clinical Trials. N Engl J Med. 2018 05 31; 378(22):2115-2122. PMID: 29847757.
     
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