Ralph D'Agostino, PhD
Professor
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics

PhD, Harvard University
AM, Boston University
AB, Boston University



Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Co-Director
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit

Investigator
Framingham Heart Study




Optimizing Cardiovascular Risk Prediction in HIV
12/15/2016 - 11/30/2021 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL132786-04

Progerin as a Biomarker for Hutchinson-Gilford Progeria Syndrome
09/01/2019 - 08/31/2021 (Multi-PI)
PI: Ralph D'Agostino, PhD
Progeria Research Foundation HHS FDA
1U01FD006886-01

Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao
09/04/2012 - 04/28/2013 (Co-Investigator)
PI: Joseph Massaro, PhD
Prometrika, Inc.


Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Ben-Joseph RH, Somers VK, Black J, D'Agostino RB, Davis M, Macfadden W, Mues KE, Jackson C, Ni W, Cook MN, White WB. Increased Risk of New-Onset Hypertension in Patients With Narcolepsy Initiating Sodium Oxybate: A Real-World Study. Mayo Clin Proc. 2024 Aug 22. PMID: 39177543
     
  2. Yogeswaran V, Kim Y, Franco RL, Lucas AR, Sutton AL, LaRose JG, Kenyon J, D'Agostino RB, Sheppard VB, Reding K, Hundley WG, Cheng RK. Association of poverty-income ratio with cardiovascular disease and mortality in cancer survivors in the United States. PLoS One. 2024; 19(7):e0300154. PMID: 38968306; PMCID: PMC11226125; DOI: 10.1371/journal.pone.0300154;
     
  3. Reding KW, Szewczyk W, D'Agostino RB, O'Connell NS, Vasbinder A, Bellissimo MP, Lucas AR, Sheppard VB, Sutton AL, Ky B, Lesser GJ, Hundley WG. Black-White Disparities in Submaximal Exercise Capacity Reductions in Breast Cancer Survivors: A Prospective Cohort Study. JACC CardioOncol. 2024 Jun; 6(3):467-469. PMID: 38983384; PMCID: PMC11229545; DOI: 10.1016/j.jaccao.2024.05.003;
     
  4. Mabudian L, Reding K, D'Agostino RB, Heiston EM, Bellissimo MP, Olson K, Ntim WO, Klepin HD, Dressler EV, Moore T, Jordan JH, O'Connell NS, Ladd A, Weaver KE, Ky B, Wagner LI, Hackney MH, Lesser GJ, Hundley WG. The relationship between body composition and left ventricular performance in women with breast, lymphoma, or sarcoma cancer. Cardiooncology. 2024 Jun 06; 10(1):34. PMID: 38845066; PMCID: PMC11155055; DOI: 10.1186/s40959-024-00233-1;
     
  5. Triant VA, Lyass A, Hurley LB, Borowsky LH, Ehrbar RQ, He W, Cheng D, Lo J, Klein DB, Meigs JB, Grinspoon SK, Plutzky J, Silverberg MJ, LaValley M, Massaro JM, D'Agostino RB. Cardiovascular Risk Estimation Is Suboptimal in People With HIV. J Am Heart Assoc. 2024 May 21; 13(10):e029228.View Related Profiles. PMID: 38761071; PMCID: PMC11179796; DOI: 10.1161/JAHA.123.029228;
     
  6. Garg R, D'Agostino RB, O'Connell N, Lesser GJ, Salloum FN, Hines AL, Meléndez GC, Jordan JH, Ky B, Wagner LI, Sutton AL, Bottinor W, Olson KC, Ladd AC, Hundley WG. Hypertension Severity and Declines in Left Ventricular Ejection Fraction Among Women Receiving Adjuvant Chemotherapy for Breast Cancer (WF-97415 UPBEAT). Hypertension. 2024 Jun; 81(6):1365-1373. PMID: 38634292; PMCID: PMC11304519; DOI: 10.1161/HYPERTENSIONAHA.123.21817;
     
  7. D'Agostino McGowan L, Pencina M, Sullivan L, D'Agostino RB. In Memoriam: Ralph B. D'Agostino, Sr. (1940-2023). Am J Epidemiol. 2024 Mar 06.View Related Profiles. PMID: 38451245
     
  8. Douglas E, Levine B, Ansari A, Ansley K, Melin S, Park CJ, Richardson K, Hatcher S, D'Agostino RB, Jordan JH, Thomas A. Impact of Anti-Estrogen Therapy on Early Cardiovascular Referrals, Tests and Medications in Premenopausal Women with Operable Breast Cancer. Clin Breast Cancer. 2024 Jun; 24(4):e289-e296. PMID: 38458842; PMCID: PMC11162933; DOI: 10.1016/j.clbc.2024.02.006;
     
  9. Jones AG, Shields BM, Oram RA, Dabelea DM, Hagopian WA, Lustigova E, Shah AS, Knupp J, Mottl AK, D'Agostino RB, Williams A, Marcovina SM, Pihoker C, Divers J, Redondo MJ. Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2024 Jan 22. PMID: 38252849
     
  10. Burcher KM, Bloomer CH, Gavrila E, Kalada JM, Chang MJ, Gebeyehu RR, Song AH, Khoury LM, Lycan TW, Kinney R, D'Agostino R, Bunch PM, Shukla K, Triozzi P, Furdui CM, Zhang W, Porosnicu M. Study protocol: phase II study to evaluate the effect of cetuximab monotherapy after immunotherapy with PD-1 inhibitors in patients with head and neck squamous cell cancer. Ther Adv Med Oncol. 2024; 16:17588359231217959. PMID: 38249330; PMCID: PMC10799583; DOI: 10.1177/17588359231217959;
     
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