Ralph D'Agostino, PhD
Boston University Graduate School of Arts and Sciences
Dept of Mathematics and Statistics

PhD, Harvard University
AM, Boston University

Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Boston University School of Public Health

Boston University School of Public Health

Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit

Framingham Heart Study

2008 US Food and Drug Administration: Advisory Committee Service Award
2006 Remington Lecturer for Cardiovascular Epidemiology Section of the American Heart Association meeting
1997 Massachusetts Health Data Consortium, Inc: Investing in Information Award at HealthMart '97
1996 Lowell Reed Lecturer at the American Public Health Association Meeting, November Meeting
1995 University of Wisconsin: Rankin Visiting Professor in Epidemiology and Preventive Medicine
1995 Federal Food and Drug Administration: Commissioner's Special Citation
1993 Boston Chapter American Statistical Association: Statistician of the Year
1985 Boston University: Metcalf Cup and Prize for Excellence in Teaching
1981 Federal Food and Drug Administration: Commissioner's Special Citation
1974 Boston University College of Liberal Arts: Distinguished Alumni
1965-1968 National Institutes of Health Predoctoral Fellow

Cardiovascular Risk Reduction in an Aging HIV-Infected Population: The Impact of HCV Co-Infection
05/01/2019 - 01/31/2024 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NIA

Optimizing Cardiovascular Risk Prediction in HIV
12/15/2016 - 11/30/2021 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NHLBI

Progerin as a Biomarker for Hutchinson-Gilford Progeria Syndrome
09/01/2019 - 08/31/2021 (Multi-PI)
PI: Ralph D'Agostino, PhD
Progeria Research Foundation HHS FDA

Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao
09/04/2012 - 04/28/2013 (Co-Investigator)
PI: Joseph Massaro, PhD
Prometrika, Inc.

Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Psioda MA, Jones SB, Xenakis JG, D'Agostino RB. Methodological Challenges and Statistical Approaches in the COMprehensive Post-Acute Stroke Services Study. Med Care. 2021 Aug 01; 59(Suppl 4):S355-S363. PMID: 34228017; PMCID: PMC8263146; DOI: 10.1097/MLR.0000000000001580;
  2. Achhra AC, Lyass A, Borowsky L, Bogorodskaya M, Plutzky J, Massaro JM, D'Agostino RB, Triant VA. Assessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations. Curr HIV/AIDS Rep. 2021 Aug; 18(4):271-279.View Related Profiles. PMID: 34247329
  3. Shah AS, Isom S, Dabelea D, D'Agostino R, Dolan LM, Wagenknecht L, Imperatore G, Saydah S, Liese AD, Lawrence JM, Pihoker C, Urbina EM. A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study. Cardiovasc Diabetol. 2021 Jul 07; 20(1):136. PMID: 34233679; PMCID: PMC8265135; DOI: 10.1186/s12933-021-01328-0;
  4. Forsythe SD, Erali RA, Sasikumar S, Laney P, Shelkey E, D'Agostino R, Miller LD, Shen P, Levine EA, Soker S, Votanopoulos KI. Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study. Clin Cancer Res. 2021 Jul 01. PMID: 34210684
  5. Burcher KM, Faucheux AT, Lantz JW, Wilson HL, Abreu A, Salafian K, Patel MJ, Song AH, Petro RM, Lycan T, Furdui CM, Topaloglu U, D'Agostino RB, Zhang W, Porosnicu M. Prevalence of DNA Repair Gene Mutations in Blood and Tumor Tissue and Impact on Prognosis and Treatment in HNSCC. Cancers (Basel). 2021 Jun 22; 13(13). PMID: 34206538; PMCID: PMC8267691; DOI: 10.3390/cancers13133118;
  6. Jensen ET, Stafford JM, Saydah S, D'Agostino RB, Dolan LM, Lawrence JM, Marcovina S, Mayer-Davis EJ, Pihoker C, Rewers A, Dabelea D. Increase in Prevalence of Diabetic Ketoacidosis at Diagnosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021 Jun 07. PMID: 34099516
  7. Taron J, Lyass A, Mahoney TF, Ehrbar RQ, Vasan RS, D'Agostino RB, Hoffmann U, Massaro JM, Lu MT. Coronary Artery Calcium Score-Directed Primary Prevention With Statins on the Basis of the 2018 American College of Cardiology/American Heart Association/Multisociety Cholesterol Guidelines. J Am Heart Assoc. 2021 01 05; 10(1):e018342.View Related Profiles. PMID: 33348999; PMCID: PMC7955488; DOI: 10.1161/JAHA.120.018342;
  8. Chow FC, Lyass A, Mahoney TF, Massaro JM, Triant VA, Wu K, Berzins B, Robertson K, Ellis RJ, Tassiopoulos K, Taiwo B, D'Agostino RB. Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2020 12 15; 71(12):3079-3085.View Related Profiles. PMID: 31899478; PMCID: PMC7819524; DOI: 10.1093/cid/ciz1214;
  9. Bogorodskaya M, Lyass A, Mahoney TF, Borowsky LH, Sen P, Swirski FK, Srinivasa S, Longenecker CT, Massaro JM, D'Agostino RB, Triant VA. Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV. HIV Med. 2021 Apr; 22(4):314-320.View Related Profiles. PMID: 33295150; PMCID: PMC7954843; DOI: 10.1111/hiv.13018;
  10. Janjua SA, Massaro JM, Chuang ML, D'Agostino RB, Hoffmann U, O'Donnell CJ. Thresholds for Abdominal Aortic Calcium That Predict Cardiovascular Disease Events in the Framingham Heart Study. JACC Cardiovasc Imaging. 2021 Mar; 14(3):695-697.View Related Profiles. PMID: 33221220
Showing 10 of 748 results. Show More