Ralph D'Agostino, PhD
Professor
Boston University Graduate School of Arts and Sciences
Dept of Mathematics and Statistics

PhD, Harvard University
AM, Boston University




Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Professor
Boston University School of Public Health
Biostatistics


Professor
Boston University School of Public Health
Epidemiology


Co-Director
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit

Investigator
Framingham Heart Study



2008 US Food and Drug Administration: Advisory Committee Service Award
2006 Remington Lecturer for Cardiovascular Epidemiology Section of the American Heart Association meeting
1997 Massachusetts Health Data Consortium, Inc: Investing in Information Award at HealthMart '97
1996 Lowell Reed Lecturer at the American Public Health Association Meeting, November Meeting
1995 University of Wisconsin: Rankin Visiting Professor in Epidemiology and Preventive Medicine
1995 Federal Food and Drug Administration: Commissioner's Special Citation
1993 Boston Chapter American Statistical Association: Statistician of the Year
1985 Boston University: Metcalf Cup and Prize for Excellence in Teaching
1981 Federal Food and Drug Administration: Commissioner's Special Citation
1974 Boston University College of Liberal Arts: Distinguished Alumni
1965-1968 National Institutes of Health Predoctoral Fellow


Cardiovascular Risk Reduction in an Aging HIV-Infected Population: The Impact of HCV Co-Infection
05/01/2019 - 01/31/2024 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NIA
5R01AG062393-02

Optimizing Cardiovascular Risk Prediction in HIV
12/15/2016 - 11/30/2020 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL132786-04

Progerin as a Biomarker for Hutchinson-Gilford Progeria Syndrome
09/01/2019 - 08/31/2020 (Subcontract PI)
Progeria Research Foundation HHS FDA
1U01FD006886-01

Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao
09/04/2012 - 04/28/2013 (Co-PI)
PI: Joseph Massaro, PhD
Prometrika, Inc.


Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Gmeiner WH, Dominijanni A, Haber AO, Ghiraldeli LP, Caudell DL, D'Agostino R, Pasche BC, Smith TL, Deng Z, Kiren S, Mani C, Palle K, Brody JR. Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties. Mol Cancer Ther. 2020 Dec 23. PMID: 33361273
     
  2. Taron J, Lyass A, Mahoney TF, Ehrbar RQ, Vasan RS, D'Agostino RB, Hoffmann U, Massaro JM, Lu MT. Coronary Artery Calcium Score-Directed Primary Prevention With Statins on the Basis of the 2018 American College of Cardiology/American Heart Association/Multisociety Cholesterol Guidelines. J Am Heart Assoc. 2021 Jan 05; 10(1):e018342.View Related Profiles. PMID: 33348999
     
  3. Chow FC, Lyass A, Mahoney TF, Massaro JM, Triant VA, Wu K, Berzins B, Robertson K, Ellis RJ, Tassiopoulos K, Taiwo B, D'Agostino RB. Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2020 Dec 15; 71(12):3079-3085.View Related Profiles. PMID: 31899478
     
  4. Bogorodskaya M, Lyass A, Mahoney TF, Borowsky LH, Sen P, Swirski FK, Srinivasa S, Longenecker CT, Massaro JM, D'Agostino RB, Triant VA. Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV. HIV Med. 2020 Dec 08.View Related Profiles. PMID: 33295150
     
  5. Janjua SA, Massaro JM, Chuang ML, D'Agostino RB, Hoffmann U, O'Donnell CJ. Thresholds for Abdominal Aortic Calcium That Predict Cardiovascular Disease Events in the Framingham Heart Study. JACC Cardiovasc Imaging. 2020 Nov 12.View Related Profiles. PMID: 33221220
     
  6. Islam N, Bukhari Q, Jameel Y, Shabnam S, Erzurumluoglu AM, Siddique MA, Massaro JM, D'Agostino RB. COVID-19 and climatic factors: A global analysis. Environ Res. 2021 Feb; 193:110355.View Related Profiles. PMID: 33127399
     
  7. Baden LR, Solomon CG, Greene MF, D'Agostino RB, Harrington D. The FDA and the Importance of Trust. N Engl J Med. 2020 12 31; 383(27):e148. PMID: 32997901
     
  8. Hundley WG, D'Agostino RB. Mid-Cancer Left Ventricular Function Measures Predict Long-Term Post-Cancer Left Ventricular Ejection Fraction. JACC Cardiovasc Imaging. 2020 Dec; 13(12):2697. PMID: 32861650
     
  9. Bukhari Q, Jameel Y, Massaro JM, D'Agostino RB, Khan S. Periodic Oscillations in Daily Reported Infections and Deaths for Coronavirus Disease 2019. JAMA Netw Open. 2020 08 03; 3(8):e2017521.View Related Profiles. PMID: 32804210
     
  10. Bukhari Q, Massaro JM, D'Agostino RB, Khan S. Effects of Weather on Coronavirus Pandemic. Int J Environ Res Public Health. 2020 07 27; 17(15).View Related Profiles. PMID: 32727067
     
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