Ralph D'Agostino, PhD
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics

PhD, Harvard University
AM, Boston University
AB, Boston University

Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit

Framingham Heart Study

Optimizing Cardiovascular Risk Prediction in HIV
12/15/2016 - 11/30/2021 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI

Progerin as a Biomarker for Hutchinson-Gilford Progeria Syndrome
09/01/2019 - 08/31/2021 (Multi-PI)
PI: Ralph D'Agostino, PhD
Progeria Research Foundation HHS FDA

Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao
09/04/2012 - 04/28/2013 (Co-Investigator)
PI: Joseph Massaro, PhD
Prometrika, Inc.

Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Gordon LB, Norris W, Hamren S, Goodson R, LeClair J, Massaro J, Lyass A, D'Agostino RB, Tuminelli K, Kieran MW, Kleinman ME. Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation. Circulation. 2023 Jun 06; 147(23):1734-1744. PMID: 36919608; PMCID: PMC10237348; DOI: 10.1161/CIRCULATIONAHA.122.060002;
  2. Taylor CN, Wang D, Larson MG, Lau ES, Benjamin EJ, D'Agostino RB, Vasan RS, Levy D, Cheng S, Ho JE. Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease. J Am Heart Assoc. 2023 Mar 21; 12(6):e027881.View Related Profiles. PMID: 36892090; PMCID: PMC10111537; DOI: 10.1161/JAHA.122.027881;
  3. Hong C, Pencina MJ, Wojdyla DM, Hall JL, Judd SE, Cary M, Engelhard MM, Berchuck S, Xian Y, D'Agostino R, Howard G, Kissela B, Henao R. Predictive Accuracy of Stroke Risk Prediction Models Across Black and White Race, Sex, and Age Groups. JAMA. 2023 Jan 24; 329(4):306-317.View Related Profiles. PMID: 36692561; PMCID: PMC10408266; DOI: 10.1001/jama.2022.24683;
  4. Malloy J, Berry E, Correia A, Fragala-Pinkham M, Coucci S, Riley S, Spratt J, Knight Pfaffinger J, Massaro J, Ehrbar R, D'Agostino R, Gurary EB, Gordon LB, Kleinman ME. Baseline Range of Motion, Strength, Motor Function, and Participation in Youth with Hutchinson-Gilford Progeria Syndrome. Phys Occup Ther Pediatr. 2023; 43(4):482-501. PMID: 36628480; PMCID: PMC10496152; DOI: 10.1080/01942638.2022.2158054;
  5. Lang R, Humes E, Hogan B, Lee J, D'Agostino R, Massaro J, Kim A, Meigs JB, Borowsky L, He W, Lyass A, Cheng D, Kim HN, Klein MB, Cachay ER, Bosch RJ, Gill MJ, Silverberg MJ, Thorne JE, McGinnis K, Horberg MA, Sterling TR, Triant VA, Althoff KN. Evaluating the Cardiovascular Risk in an Aging Population of People With HIV: The Impact of Hepatitis C Virus Coinfection. J Am Heart Assoc. 2022 Oct 04; 11(19):e026473. PMID: 36129038; PMCID: PMC9673707; DOI: 10.1161/JAHA.122.026473;
  6. Selker HP, Cohen T, D'Agostino RB, Dere WH, Ghaemi SN, Honig PK, Kaitin KI, Kaplan HC, Kravitz RL, Larholt K, McElwee NE, Oye KA, Palm ME, Perfetto E, Ramanathan C, Schmid CH, Seyfert-Margolis V, Trusheim M, Eichler HG. A Useful and Sustainable Role for N-of-1 Trials in the Healthcare Ecosystem. Clin Pharmacol Ther. 2022 Aug; 112(2):224-232. PMID: 34551122; PMCID: PMC9022728; DOI: 10.1002/cpt.2425;
  7. Sauder KA, Stafford JM, Ehrlich S, Lawrence JM, Liese AD, Marcovina S, Mottl AK, Pihoker C, Saydah S, Shah AS, D'Agostino RB, Dabelea D. Disparities in Hemoglobin A1c Testing During the Transition to Adulthood and Association With Diabetes Outcomes in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021 Aug 10; 44(10):2320-8. PMID: 34376501; PMCID: PMC8929181; DOI: 10.2337/dc20-2983;
  8. Achhra AC, Lyass A, Borowsky L, Bogorodskaya M, Plutzky J, Massaro JM, D'Agostino RB, Triant VA. Assessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations. Curr HIV/AIDS Rep. 2021 08; 18(4):271-279.View Related Profiles. PMID: 34247329; PMCID: PMC8733948; DOI: 10.1007/s11904-021-00567-w;
  9. Taron J, Lyass A, Mahoney TF, Ehrbar RQ, Vasan RS, D'Agostino RB, Hoffmann U, Massaro JM, Lu MT. Coronary Artery Calcium Score-Directed Primary Prevention With Statins on the Basis of the 2018 American College of Cardiology/American Heart Association/Multisociety Cholesterol Guidelines. J Am Heart Assoc. 2021 01 05; 10(1):e018342.View Related Profiles. PMID: 33348999; PMCID: PMC7955488; DOI: 10.1161/JAHA.120.018342;
  10. Chow FC, Lyass A, Mahoney TF, Massaro JM, Triant VA, Wu K, Berzins B, Robertson K, Ellis RJ, Tassiopoulos K, Taiwo B, D'Agostino RB. Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2020 12 15; 71(12):3079-3085. PMID: 31899478; PMCID: PMC7819524; DOI: 10.1093/cid/ciz1214;
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