Ralph D'Agostino, PhD
Professor
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics

PhD, Harvard University
AM, Boston University
AB, Boston University



Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Co-Director
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit

Investigator
Framingham Heart Study




Optimizing Cardiovascular Risk Prediction in HIV
12/15/2016 - 11/30/2021 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL132786-04

Progerin as a Biomarker for Hutchinson-Gilford Progeria Syndrome
09/01/2019 - 08/31/2021 (Multi-PI)
PI: Ralph D'Agostino, PhD
Progeria Research Foundation HHS FDA
1U01FD006886-01

Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao
09/04/2012 - 04/28/2013 (Co-Investigator)
PI: Joseph Massaro, PhD
Prometrika, Inc.


Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. D'Agostino McGowan L, Pencina M, Sullivan L, D'Agostino RB. In Memoriam: Ralph B. D'Agostino, Sr. (1940-2023). Am J Epidemiol. 2024 Mar 06.View Related Profiles. PMID: 38451245
     
  2. Douglas E, Levine B, Ansari A, Ansley K, Melin S, Park CJ, Richardson K, Hatcher S, D'Agostino RB, Jordan JH, Thomas A. Impact of Anti-Estrogen Therapy on Early Cardiovascular Referrals, Tests and Medications in Premenopausal Women with Operable Breast Cancer. Clin Breast Cancer. 2024 Feb 16. PMID: 38458842
     
  3. Jones AG, Shields BM, Oram RA, Dabelea DM, Hagopian WA, Lustigova E, Shah AS, Knupp J, Mottl AK, D'Agostino RB, Williams A, Marcovina SM, Pihoker C, Divers J, Redondo MJ. Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2024 Jan 22. PMID: 38252849
     
  4. Burcher KM, Bloomer CH, Gavrila E, Kalada JM, Chang MJ, Gebeyehu RR, Song AH, Khoury LM, Lycan TW, Kinney R, D'Agostino R, Bunch PM, Shukla K, Triozzi P, Furdui CM, Zhang W, Porosnicu M. Study protocol: phase II study to evaluate the effect of cetuximab monotherapy after immunotherapy with PD-1 inhibitors in patients with head and neck squamous cell cancer. Ther Adv Med Oncol. 2024; 16:17588359231217959. PMID: 38249330; DOI: 10.1177/17588359231217959;
     
  5. Gordon LB, Norris W, Hamren S, Goodson R, LeClair J, Massaro J, Lyass A, D'Agostino RB, Tuminelli K, Kieran MW, Kleinman ME. Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation. Circulation. 2023 Jun 06; 147(23):1734-1744. PMID: 36919608; DOI: 10.1161/CIRCULATIONAHA.122.060002;
     
  6. Taylor CN, Wang D, Larson MG, Lau ES, Benjamin EJ, D'Agostino RB, Vasan RS, Levy D, Cheng S, Ho JE. Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease. J Am Heart Assoc. 2023 Mar 21; 12(6):e027881.View Related Profiles. PMID: 36892090; DOI: 10.1161/JAHA.122.027881;
     
  7. Hong C, Pencina MJ, Wojdyla DM, Hall JL, Judd SE, Cary M, Engelhard MM, Berchuck S, Xian Y, D'Agostino R, Howard G, Kissela B, Henao R. Predictive Accuracy of Stroke Risk Prediction Models Across Black and White Race, Sex, and Age Groups. JAMA. 2023 Jan 24; 329(4):306-317.View Related Profiles. PMID: 36692561; DOI: 10.1001/jama.2022.24683;
     
  8. Malloy J, Berry E, Correia A, Fragala-Pinkham M, Coucci S, Riley S, Spratt J, Knight Pfaffinger J, Massaro J, Ehrbar R, D'Agostino R, Gurary EB, Gordon LB, Kleinman ME. Baseline Range of Motion, Strength, Motor Function, and Participation in Youth with Hutchinson-Gilford Progeria Syndrome. Phys Occup Ther Pediatr. 2023; 43(4):482-501. PMID: 36628480; DOI: 10.1080/01942638.2022.2158054;
     
  9. Lang R, Humes E, Hogan B, Lee J, D'Agostino R, Massaro J, Kim A, Meigs JB, Borowsky L, He W, Lyass A, Cheng D, Kim HN, Klein MB, Cachay ER, Bosch RJ, Gill MJ, Silverberg MJ, Thorne JE, McGinnis K, Horberg MA, Sterling TR, Triant VA, Althoff KN. Evaluating the Cardiovascular Risk in an Aging Population of People With HIV: The Impact of Hepatitis C Virus Coinfection. J Am Heart Assoc. 2022 Oct 04; 11(19):e026473. PMID: 36129038; DOI: 10.1161/JAHA.122.026473;
     
  10. Selker HP, Cohen T, D'Agostino RB, Dere WH, Ghaemi SN, Honig PK, Kaitin KI, Kaplan HC, Kravitz RL, Larholt K, McElwee NE, Oye KA, Palm ME, Perfetto E, Ramanathan C, Schmid CH, Seyfert-Margolis V, Trusheim M, Eichler HG. A Useful and Sustainable Role for N-of-1 Trials in the Healthcare Ecosystem. Clin Pharmacol Ther. 2022 Aug; 112(2):224-232. PMID: 34551122; DOI: 10.1002/cpt.2425;
     
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