Ralph D'Agostino, PhD
Professor
Boston University Graduate School of Arts and Sciences
Dept of Mathematics and Statistics

PhD, Harvard University
AM, Boston University




Ralph B. D’Agostino, Sr., is Chairman of the Mathematics and Statistics Department and Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968). His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.

He has extensive experience (since the 1980’s) developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a fellow of the American Statistical Association and the Cardiovascular Epidemiology Council of the American Heart Association.

He has been with the Framingham Heart Study since 1981 and is Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study.

He is a Special Government Employee (SGE) to the United States’ Food and Drug Administration (FDA). He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He has also been a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA’s Commissioner’s Special Citation (1981 and 1995).

Professor
Boston University School of Public Health
Biostatistics


Professor
Boston University School of Public Health
Epidemiology


Co-Director
Boston University Graduate School of Arts and Sciences
Mathematics and Statistics
Statistical Consulting Unit

Investigator
Framingham Heart Study



2008 US Food and Drug Administration: Advisory Committee Service Award
2006 Remington Lecturer for Cardiovascular Epidemiology Section of the American Heart Association meeting
1997 Massachusetts Health Data Consortium, Inc: Investing in Information Award at HealthMart '97
1996 Lowell Reed Lecturer at the American Public Health Association Meeting, November Meeting
1995 University of Wisconsin: Rankin Visiting Professor in Epidemiology and Preventive Medicine
1995 Federal Food and Drug Administration: Commissioner's Special Citation
1993 Boston Chapter American Statistical Association: Statistician of the Year
1985 Boston University: Metcalf Cup and Prize for Excellence in Teaching
1981 Federal Food and Drug Administration: Commissioner's Special Citation
1974 Boston University College of Liberal Arts: Distinguished Alumni
1965-1968 National Institutes of Health Predoctoral Fellow


Optimizing Cardiovascular Risk Prediction in HIV
12/15/2016 - 11/30/2020 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL132786-03

Prometrika, LLC: Statistical Research in Clinical Trials - Baiyun Yao
09/04/2012 - 04/28/2013 (Co-PI)
PI: Joseph Massaro, PhD
Prometrika, Inc.


Sleep Heart Health Study
09/30/1999 - 08/31/2004 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL53941 09

The Framingham Nutrition Studies
09/01/1998 - 07/31/2002 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60700 03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Renfrow JJ, Soike MH, West JL, Ramkissoon SH, Metheny-Barlow L, Mott RT, Kittel CA, D'Agostino RB, Tatter SB, Laxton AW, Frenkel MB, Hawkins GA, Herpai D, Sanders S, Sarkaria JN, Lesser GJ, Debinski W, Strowd RE. Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor. Sci Rep. 2020 Sep 16; 10(1):15195. PMID: 32938997
     
  2. Hassan MS, Pullikuth A, Nelson KC, Flores A, Karpova Y, Baiz D, Zhu S, Sui G, Huang Y, D'Agostino R, Hemal A, von Holzen U, Debinski W, Kulik G. Beta2-adrenoreceptor signaling increases therapy-resistance in prostate cancer by upregulating MCL1. Mol Cancer Res. 2020 Sep 14. PMID: 32928910
     
  3. Hundley WG, D'Agostino RB. Mid-Cancer Left Ventricular Function Measures Predict Long-Term Post-Cancer Left Ventricular Ejection Fraction. JACC Cardiovasc Imaging. 2020 Aug 24. PMID: 32861650
     
  4. Bukhari Q, Jameel Y, Massaro JM, D'Agostino RB, Khan S. Periodic Oscillations in Daily Reported Infections and Deaths for Coronavirus Disease 2019. JAMA Netw Open. 2020 08 03; 3(8):e2017521.View Related Profiles. PMID: 32804210
     
  5. Bukhari Q, Massaro JM, D'Agostino RB, Khan S. Effects of Weather on Coronavirus Pandemic. Int J Environ Res Public Health. 2020 07 27; 17(15).View Related Profiles. PMID: 32727067
     
  6. Sande SZ, Li J, D'Agostino R, Yin Wong T, Cheng CY. Statistical inference for decision curve analysis, with applications to cataract diagnosis. Stat Med. 2020 Sep 30; 39(22):2980-3002. PMID: 32667093
     
  7. Islam N, Sharp SJ, Chowell G, Shabnam S, Kawachi I, Lacey B, Massaro JM, D'Agostino RB, White M. Physical distancing interventions and incidence of coronavirus disease 2019: natural experiment in 149 countries. BMJ. 2020 07 15; 370:m2743.View Related Profiles. PMID: 32669358
     
  8. Manini TM, Patel SM, Newman AB, Travison TG, Kiel DP, Shardell MD, Pencina KM, Wilson KE, Kelly TL, Massaro JM, Fielding RA, Magaziner J, Correa-de-Araujo R, Kwok TCY, Hirani V, Karlsson MK, D'Agostino RB, Mellström D, Ohlsson C, Ribom E, Jordan JM, Bhasin S, Cawthon PM. Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis. J Am Geriatr Soc. 2020 Jul; 68(7):1419-1428.View Related Profiles. PMID: 32633834
     
  9. Cawthon PM, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Brown T, Kiel DP, Cummings SR, Shardell M, Guralnik JM, Woodhouse LJ, Pahor M, Binder E, D'Agostino RB, Quian-Li X, Orwoll E, Landi F, Orwig D, Schaap L, Latham NK, Hirani V, Kwok T, Pereira SL, Rooks D, Kashiwa M, Torres-Gonzalez M, Menetski JP, Correa-De-Araujo R, Bhasin S. Establishing the Link Between Lean Mass and Grip Strength Cut Points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference. J Gerontol A Biol Sci Med Sci. 2020 Jun 18; 75(7):1317-1323. PMID: 30869772
     
  10. Jarcho JA, Ingelfinger JR, Hamel MB, D'Agostino RB, Harrington DP. Inhibitors of the Renin-Angiotensin-Aldosterone System and Covid-19. N Engl J Med. 2020 06 18; 382(25):2462-2464. PMID: 32356625
     
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