Mark W. Logue, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Psychiatry

PhD, University of Iowa
MS, University of Iowa
BS, University of Oregon



My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Associate Professor
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System


Member
Boston University
Genome Science Institute




The impact of traumatic stress on the methylome: implications for PTSD
08/21/2020 - 05/31/2025 (Subcontract PI)
Emory University NIH NIMH
5R01MH108826-07

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2019 - 07/31/2022 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-04

The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2020 (Subcontract PI)
Emory University NIH NIMH
5R01MH108826-04

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2018 - 07/31/2019 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-02

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
09/06/2017 - 07/31/2018 (Subcontract PI)
Duke University NIH NIMH
1R01MH111671-01A1

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05



Title
The Impact of Traumatic Stress on the Methylome: Implications for PTSD
(PI)

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
(PI)

Early cognitive Impairment as a Function of Alzheimer's Disease Genes and Trauma
(PI)

Genetic and Epigenetic Biomarkers of PTSD
(PI)



Yr Title Project-Sub Proj Pubs
2023 Early Cognitive Impairment as a function of Alzheimer's Disease and Trauma 1I01BX005749-01A1
2023 Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma 5I01BX004192-04
2023 Genomic Architecture of Functional Brain Networks in PTSD 2R01MH111671-05
2022 The Impact of Traumatic Stress on the Methylome: implications for PTSD 5R01MH108826-07
2021 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-03
2021 The Impact of Traumatic Stress on the Methylome: implications for PTSD 5R01MH108826-06 7
2020 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-02
2020 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-04 11
2020 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-04 8
2020 The Impact of Traumatic Stress on the Methylome: implications for PTSD 2R01MH108826-05A1 7
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Le Guen Y, Raulin AC, Logue MW, Sherva R, Belloy ME, Eger SJ, Chen A, Kennedy G, Kuchenbecker L, O'Leary JP, Zhang R, Merritt VC, Panizzon MS, Hauger RL, Gaziano JM, Bu G, Thornton TA, Farrer LA, Napolioni V, He Z, Greicius MD. Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease. JAMA. 2023 Feb 21; 329(7):551-560.View Related Profiles. PMID: 36809323; PMCID: PMC9945061; DOI: 10.1001/jama.2023.0268;
     
  2. Hawn SE, Zhao X, Sullivan DR, Logue M, Fein-Schaffer D, Milberg W, McGlinchey R, Miller MW, Wolf EJ. Correction to: For whom the bell tolls: psychopathological and neurobiological correlates of a DNA methylation index of time-to-death. Transl Psychiatry. 2023 Feb 15; 13(1):56.View Related Profiles. PMID: 36792580; PMCID: PMC9932008; DOI: 10.1038/s41398-023-02340-6;
     
  3. Rakesh G, Logue MW, Clarke-Rubright E, Haswell CC, Thompson PM, De Bellis MD, Morey RA, Sun D. Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study. Brain Connect. 2023 Feb 09. PMID: 36511392
     
  4. Hayes JP, Pierce ME, Brown E, Salat D, Logue MW, Constantinescu J, Valerio K, Miller MW, Sherva R, Huber BR, Milberg W, McGlinchey R. Genetic Risk for Alzheimer Disease and Plasma Tau Are Associated With Accelerated Parietal Cortex Thickness Change in Middle-Aged Adults. Neurol Genet. 2023 Feb; 9(1):e200053.View Related Profiles. PMID: 36742995; PMCID: PMC9893442; DOI: 10.1212/NXG.0000000000200053;
     
  5. Logue MW, Miller MW, Sherva R, Zhang R, Harrington KM, Fonda JR, Merritt VC, Panizzon MS, Hauger RL, Wolf EJ, Neale Z, Gaziano JM. Alzheimer's disease and related dementias among aging veterans: Examining gene-by-environment interactions with post-traumatic stress disorder and traumatic brain injury. Alzheimers Dement. 2022 Dec 22.View Related Profiles. PMID: 36546606
     
  6. Sherva R, Zhang R, Sahelijo N, Jun G, Anglin T, Chanfreau C, Cho K, Fonda JR, Gaziano JM, Harrington KM, Ho YL, Kremen WS, Litkowski E, Lynch J, Neale Z, Roussos P, Marra D, Mez J, Miller MW, Salat DH, Tsuang D, Wolf E, Zeng Q, Panizzon MS, Merritt VC, Farrer LA, Hauger RL, Logue MW. African ancestry GWAS of dementia in a large military cohort identifies significant risk loci. Mol Psychiatry. 2023 Mar; 28(3):1293-1302.View Related Profiles. PMID: 36543923
     
  7. Litkowski EM, Logue MW, Zhang R, Charest BR, Lange EM, Hokanson JE, Lynch JA, Vujkovic M, Phillips LS, Lange LA, Hauger RL, Raghavan S. A Diabetes Genetic Risk Score Is Associated With All-Cause Dementia and Clinically Diagnosed Vascular Dementia in the Million Veteran Program. Diabetes Care. 2022 Nov 01; 45(11):2544-2552. PMID: 36041056; PMCID: PMC9679262; DOI: 10.2337/dc22-0105;
     
  8. Zhao X, Logue MW, Hawn SE, Neale ZE, Zhou Z, Huber BR, Miller MW, Wolf EJ. PTSD, major depression, and advanced transcriptomic age in brain tissue. Depress Anxiety. 2022 Dec; 39(12):824-834.View Related Profiles. PMID: 36281744; PMCID: PMC9729392; DOI: 10.1002/da.23289;
     
  9. Ditmars HL, Logue MW, Toomey R, McKenzie RE, Franz CE, Panizzon MS, Reynolds CA, Cuthbert KN, Vandiver R, Gustavson DE, Eglit GML, Elman JA, Sanderson-Cimino M, Williams ME, Andreassen OA, Dale AM, Eyler LT, Fennema-Notestine C, Gillespie NA, Hauger RL, Jak AJ, Neale MC, Tu XM, Whitsel N, Xian H, Kremen WS, Lyons MJ. Associations Between Depression and Cardiometabolic Health: A 27-Year Longitudinal Study - Corrigendum. Psychol Med. 2022 Oct; 52(14):3018.View Related Profiles. PMID: 36177891
     
  10. Hawn SE, Zhao X, Sullivan DR, Logue M, Fein-Schaffer D, Milberg W, McGlinchey R, Miller MW, Wolf EJ. For whom the bell tolls: psychopathological and neurobiological correlates of a DNA methylation index of time-to-death. Transl Psychiatry. 2022 Sep 24; 12(1):406.View Related Profiles. PMID: 36153327; PMCID: PMC9509393; DOI: 10.1038/s41398-022-02164-w;
     
Showing 10 of 138 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 138 publications over 24 distinct years, with a maximum of 15 publications in 2017 and 2020 and 2022

YearPublications
19981
20011
20022
20032
20043
20053
20062
20071
20081
20091
20101
20114
20127
20138
20147
20159
20164
201715
20189
201910
202015
202113
202215
20234

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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