Mark W. Logue, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Psychiatry

PhD, University of Iowa
MS, University of Iowa
BS, University of Oregon



My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Professor
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System


Member
Boston University
Genome Science Institute




The impact of traumatic stress on the methylome: implications for PTSD
08/21/2020 - 05/31/2025 (Multi-PI)
PI: Mark W. Logue, PhD
Emory University NIH NIMH
5R01MH108826-09

Genomic Architecture of Functional Brain Networks in PTSD
02/01/2023 - 12/31/2024 (Multi-PI)
PI: Mark W. Logue, PhD
Duke University NIH NIMH
5R01MH111671-06

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2019 - 07/31/2022 (Multi-PI)
PI: Mark W. Logue, PhD
Duke University NIH NIMH
5R01MH111671-04

The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2020 (Multi-PI)
PI: Mark W. Logue, PhD
Emory University NIH NIMH
5R01MH108826-04

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2018 - 07/31/2019 (Multi-PI)
PI: Mark W. Logue, PhD
Duke University NIH NIMH
5R01MH111671-02

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
09/06/2017 - 07/31/2018 (Multi-PI)
PI: Mark W. Logue, PhD
Duke University NIH NIMH
1R01MH111671-01A1

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05



Title
The Impact of Traumatic Stress on the Methylome: Implications for PTSD
(PI)

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
(PI)

Early cognitive Impairment as a Function of Alzheimer's Disease Genes and Trauma
(PI)

Genetic and Epigenetic Biomarkers of PTSD
(PI)



Yr Title Project-Sub Proj Pubs
2025 Early Cognitive Impairment as a function of Alzheimer's Disease and Trauma 5I01BX005749-03
2025 Genomic Architecture of Functional Brain Networks in PTSD 5R01MH111671-07
2024 Early Cognitive Impairment as a function of Alzheimer's Disease and Trauma 5I01BX005749-02
2024 Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma 5I01BX004192-06
2024 Genomic Architecture of Functional Brain Networks in PTSD 5R01MH111671-06
2024 The Impact of Traumatic Stress on the Methylome: implications for PTSD 5R01MH108826-09
2023 Early Cognitive Impairment as a function of Alzheimer's Disease and Trauma 1I01BX005749-01A1
2023 Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma 5I01BX004192-05
2023 Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma 5I01BX004192-04
2023 Genomic Architecture of Functional Brain Networks in PTSD 2R01MH111671-05
Showing 10 of 34 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zhao X, Katrinli S, McCormick BM, Miller MW, Nugent NR, Wani AH, Zannas AS, Aiello AE, Baker DG, Boks MP, Chen CY, Fortier CB, Gelernter J, Geuze E, Koenen KC, Linnstaedt SD, Luykx JJ, Maihofer AX, McLean SA, Milberg WP, Ratanatharathorn A, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Zhao Y, Logue MW, Nievergelt CM, Smith AK, Uddin M, Wolf EJ. PTSD and epigenetic aging: a longitudinal meta-analysis. Psychol Med. 2025 May 14; 55:e142.View Related Profiles. PMID: 40366073
     
  2. Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS. Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD. Brain Behav Immun. 2025 Apr 24; 128:540-548.View Related Profiles. PMID: 40286993
     
  3. Pierce ME, Logue M, Sherva R, Miller M, Huber BR, Milberg W, Hayes JP. Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-ß42:40 in Veterans. J Alzheimers Dis. 2025 Apr; 104(4):1006-1012.View Related Profiles. PMID: 40084666; DOI: 10.1177/13872877251321183;
     
  4. Merritt VC, Zhang R, Sherva R, Ly MT, Marra D, Panizzon MS, Tsuang DW, Hauger RL, Logue MW. Curation and validation of electronic medical record-based dementia diagnoses in the VA Million Veteran Program. J Alzheimers Dis. 2025 Jan; 103(1):180-193.View Related Profiles. PMID: 39692476
     
  5. Katrinli S, Wani AH, Maihofer AX, Ratanatharathorn A, Daskalakis NP, Montalvo-Ortiz J, Núñez-Ríos DL, Zannas AS, Zhao X, Aiello AE, Ashley-Koch AE, Avetyan D, Baker DG, Beckham JC, Boks MP, Brick LA, Bromet E, Champagne FA, Chen CY, Dalvie S, Dennis MF, Fatumo S, Fortier C, Galea S, Garrett ME, Geuze E, Grant G, Hauser MA, Hayes JP, Hemmings SMJ, Huber BR, Jajoo A, Jansen S, Kessler RC, Kimbrel NA, King AP, Kleinman JE, Koen N, Koenen KC, Kuan PF, Liberzon I, Linnstaedt SD, Lori A, Luft BJ, Luykx JJ, Marx CE, McLean SA, Mehta D, Milberg W, Miller MW, Mufford MS, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff CB, Nugent NR, Orcutt HK, Qin XJ, Rauch SAM, Ressler KJ, Risbrough VB, Rutembesa E, Rutten BPF, Seedat S, Stein DJ, Stein MB, Toikumo S, Ursano RJ, Uwineza A, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Young RM, Zhao Y, van den Heuvel LL, Uddin M, Nievergelt CM, Smith AK, Logue MW. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Med. 2024 Dec 18; 16(1):147.View Related Profiles. PMID: 39696436; PMCID: PMC11658418; DOI: 10.1186/s13073-024-01417-1;
     
  6. Morey RA, Zheng Y, Bayly H, Sun D, Garrett ME, Gasperi M, Maihofer AX, Baird CL, Grasby KL, Huggins AA, Haswell CC, Thompson PM, Medland S, Gustavson DE, Panizzon MS, Kremen WS, Nievergelt CM, Ashley-Koch AE, Logue MW. Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture. Transl Psychiatry. 2024 Oct 24; 14(1):451. PMID: 39448598; PMCID: PMC11502831; DOI: 10.1038/s41398-024-03152-y;
     
  7. Belloy ME, Le Guen Y, Stewart I, Williams K, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD. Role of the X Chromosome in Alzheimer Disease Genetics. JAMA Neurol. 2024 Oct 01; 81(10):1032-1042.View Related Profiles. PMID: 39250132; PMCID: PMC11385320; DOI: 10.1001/jamaneurol.2024.2843;
     
  8. Wani AH, Katrinli S, Zhao X, Daskalakis NP, Zannas AS, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fortier C, Geuze E, Hayes JP, Kessler RC, King AP, Koen N, Liberzon I, Lori A, Luykx JJ, Maihofer AX, Milberg W, Miller MW, Mufford MS, Nugent NR, Rauch S, Ressler KJ, Risbrough VB, Rutten BPF, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Nievergelt CM, Logue MW, Smith AK, Uddin M. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts. BMC Med Genomics. 2024 Sep 27; 17(1):235.View Related Profiles. PMID: 39334086; PMCID: PMC11429352; DOI: 10.1186/s12920-024-02002-6;
     
  9. Ahmad S, Imtiaz MA, Mishra A, Wang R, Herrera-Rivero M, Bis JC, Fornage M, Roshchupkin G, Hofer E, Logue M, Longstreth WT, Xia R, Bouteloup V, Mosley T, Launer LJ, Khalil M, Kuhle J, Rissman RA, Chene G, Dufouil C, Djoussé L, Lyons MJ, Mukamal KJ, Kremen WS, Franz CE, Schmidt R, Debette S, Breteler MMB, Berger K, Yang Q, Seshadri S, Aziz NA, Ghanbari M, Ikram MA. Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration. Commun Biol. 2024 Sep 09; 7(1):1103.View Related Profiles. PMID: 39251807; PMCID: PMC11385583; DOI: 10.1038/s42003-024-06804-3;
     
  10. Moody JN, Howard E, Nolan KE, Prieto S, Logue MW, Hayes JP. Traumatic Brain Injury and Genetic Risk for Alzheimer's Disease Impact Cerebrospinal Fluid ß-Amyloid Levels in Vietnam War Veterans. Neurotrauma Rep. 2024; 5(1):760-769. PMID: 39184178; PMCID: PMC11342050; DOI: 10.1089/neur.2024.0048;
     
Showing 10 of 168 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 168 publications over 26 distinct years, with a maximum of 16 publications in 2024

YearPublications
19981
20011
20022
20032
20043
20053
20062
20071
20081
20091
20101
20114
20127
20138
20147
20159
20164
201715
20189
201910
202015
202113
202215
202315
202416
20253
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
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72 E. Concord St Instructional (L)
Boston MA 02118
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