Mark W. Logue, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

PhD, University of Iowa
MS, University of Iowa




My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Associate Professor
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System


Member
Boston University
Genome Science Institute




Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2019 - 07/31/2020 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-03

The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2020 (Subcontract PI)
Emory University NIH NIMH
5R01MH108826-03

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2018 - 07/31/2019 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-02

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
09/06/2017 - 07/31/2018 (Subcontract PI)
Duke University NIH NIMH
1R01MH111671-01A1

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05



Title
The Impact of Traumatic Stress on the Methylome: Implications for PTSD
Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
Early cognitive Impairment as a Function of Alzheimer's Disease Genes and Trauma
Genetic and Epigenetic Biomarkers of PTSD


Yr Title Project-Sub Proj Pubs
2020 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-02
2020 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-04 11
2020 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-04 8
2020 The Impact of Traumatic Stress on the Methylome: implications for PTSD 2R01MH108826-05A1 7
2019 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 1I01BX004192-01A1
2019 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-03 11
2019 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-03 8
2019 The impact of traumatic stress on the methylome: implications for PTSD 5R01MH108826-04 7
2018 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-02 11
2018 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-02 8
Showing 10 of 20 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Li G, Raffield L, Logue M, Miller MW, Santos HP, O'Shea TM, Fry RC, Li Y. CUE: CpG impUtation ensemble for DNA methylation levels across the human methylation450 (HM450) and EPIC (HM850) BeadChip platforms. Epigenetics. 2020 Oct 04; 1-11.View Related Profiles. PMID: 33016200
     
  2. Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, DeCarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Veronica Witte A, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Bruce Pike G, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT, Fornage M, Paus T, Debette S, Arfan Ikram M, Schmidt H, Schmidt R, Seshadri S. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun. 2020 09 22; 11(1):4796.View Related Profiles. PMID: 32963231; DOI: 10.1038/s41467-020-18367-y;
     
  3. Sullivan DR, Salat DH, Wolf EJ, Logue MW, Fortier CB, Fonda JR, DeGutis J, Esterman M, Milberg WP, McGlinchey RE, Miller MW. Interpersonal early life trauma is associated with increased cerebral perfusion and poorer memory performance in post-9/11 veterans. Neuroimage Clin. 2020 Aug 01; 28:102365.View Related Profiles. PMID: 32777702
     
  4. Sullivan DR, Miller MW, Wolf EJ, Logue MW, Robinson ME, Fortier CB, Fonda JR, Wang DJ, Milberg WP, McGlinchey RE, Salat DH. Cerebral perfusion is associated with blast exposure in military personnel without moderate or severe TBI. J Cereb Blood Flow Metab. 2020 Jun 24; 271678X20935190.View Related Profiles. PMID: 32580671
     
  5. Stevens SM, Gustavson DE, Fang B, Tu X, Logue M, Lyons MJ, Reynolds CA, Kremen WS, Franz CE. Predicting Health-Related Quality of Life in Trauma-Exposed Male Veterans in Late Midlife: A 20 Year Longitudinal Study. Int J Environ Res Public Health. 2020 06 24; 17(12). PMID: 32599875
     
  6. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 Jun 02; 31(9):107716.View Related Profiles. PMID: 32492425
     
  7. Kochunov P, Hong LE, Dennis EL, Morey RA, Tate DF, Wilde EA, Logue M, Kelly S, Donohoe G, Favre P, Houenou J, Ching CRK, Holleran L, Andreassen OA, van Velzen LS, Schmaal L, Villalón-Reina JE, Bearden CE, Piras F, Spalletta G, van den Heuvel OA, Veltman DJ, Stein DJ, Ryan MC, Tan Y, van Erp TGM, Turner JA, Haddad L, Nir TM, Glahn DC, Thompson PM, Jahanshad N. ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Hum Brain Mapp. 2020 Apr 16. PMID: 32301246
     
  8. Wolf EJ, Logue MW, Zhao X, Daskalakis NP, Morrison FG, Escarfulleri S, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Chen C, Abraham CR, Miller MW. PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. Psychoneuroendocrinology. 2020 07; 117:104656.View Related Profiles. PMID: 32438247
     
  9. Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL, Hajek T, Han LKM, Hatton SN, Hilbert K, Ho TC, Holleran L, Homuth G, Hosten N, Houenou J, Ivanov I, Jia T, Kelly S, Klein M, Kwon JS, Laansma MA, Leerssen J, Lueken U, Nunes A, Neill JO, Opel N, Piras F, Piras F, Postema MC, Pozzi E, Shatokhina N, Soriano-Mas C, Spalletta G, Sun D, Teumer A, Tilot AK, Tozzi L, van der Merwe C, Van Someren EJW, van Wingen GA, Völzke H, Walton E, Wang L, Winkler AM, Wittfeld K, Wright MJ, Yun JY, Zhang G, Zhang-James Y, Adhikari BM, Agartz I, Aghajani M, Aleman A, Althoff RR, Altmann A, Andreassen OA, Baron DA, Bartnik-Olson BL, Marie Bas-Hoogendam J, Baskin-Sommers AR, Bearden CE, Berner LA, Boedhoe PSW, Brouwer RM, Buitelaar JK, Caeyenberghs K, Cecil CAM, Cohen RA, Cole JH, Conrod PJ, De Brito SA, de Zwarte SMC, Dennis EL, Desrivieres S, Dima D, Ehrlich S, Esopenko C, Fairchild G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Garavan HP, Glahn DC, Groenewold NA, Gurholt TP, Gutman BA, Hahn T, Harding IH, Hernaus D, Hibar DP, Hillary FG, Hoogman M, Hulshoff Pol HE, Jalbrzikowski M, Karkashadze GA, Klapwijk ET, Knickmeyer RC, Kochunov P, Koerte IK, Kong XZ, Liew SL, Lin AP, Logue MW, Luders E, Macciardi F, Mackey S, Mayer AR, McDonald CR, McMahon AB, Medland SE, Modinos G, Morey RA, Mueller SC, Mukherjee P, Namazova-Baranova L, Nir TM, Olsen A, Paschou P, Pine DS, Pizzagalli F, Rentería ME, Rohrer JD, Sämann PG, Schmaal L, Schumann G, Shiroishi MS, Sisodiya SM, Smit DJA, Sønderby IE, Stein DJ, Stein JL, Tahmasian M, Tate DF, Turner JA, van den Heuvel OA, van der Wee NJA, van der Werf YD, van Erp TGM, van Haren NEM, van Rooij D, van Velzen LS, Veer IM, Veltman DJ, Villalon-Reina JE, Walter H, Whelan CD, Wilde EA, Zarei M, Zelman V. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Transl Psychiatry. 2020 03 20; 10(1):100. PMID: 32198361
     
  10. Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M. An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Clin Epigenetics. 2020 03 14; 12(1):46.View Related Profiles. PMID: 32171335
     
Showing 10 of 101 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 101 publications over 21 distinct years, with a maximum of 15 publications in 2017

YearPublications
19981
20011
20022
20032
20043
20053
20062
20071
20081
20091
20101
20114
20127
20138
20147
20159
20164
201715
20189
201910
202010

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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