Mark W. Logue, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Psychiatry

PhD, University of Iowa
MS, University of Iowa



My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Associate Professor
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System


Member
Boston University
Genome Science Institute




The impact of traumatic stress on the methylome: implications for PTSD
08/21/2020 - 05/31/2025 (Subcontract PI)
Emory University NIH NIMH
5R01MH108826-07

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2019 - 07/31/2022 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-04

The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2020 (Subcontract PI)
Emory University NIH NIMH
5R01MH108826-04

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2018 - 07/31/2019 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-02

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
09/06/2017 - 07/31/2018 (Subcontract PI)
Duke University NIH NIMH
1R01MH111671-01A1

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05



Title
The Impact of Traumatic Stress on the Methylome: Implications for PTSD
(PI)

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
(PI)

Early cognitive Impairment as a Function of Alzheimer's Disease Genes and Trauma
(PI)

Genetic and Epigenetic Biomarkers of PTSD
(PI)



Yr Title Project-Sub Proj Pubs
2022 The Impact of Traumatic Stress on the Methylome: implications for PTSD 5R01MH108826-07
2021 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-03
2021 The Impact of Traumatic Stress on the Methylome: implications for PTSD 5R01MH108826-06 7
2020 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-02
2020 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-04 11
2020 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-04 8
2020 The Impact of Traumatic Stress on the Methylome: implications for PTSD 2R01MH108826-05A1 7
2019 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 1I01BX004192-01A1
2019 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-03 11
2019 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-03 8
Showing 10 of 23 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. 2022 Jun; 21(6):e13617.View Related Profiles. PMID: 35567427; PMCID: PMC9197405; DOI: 10.1111/acel.13617;
     
  2. Gillespie NA, Hatton SN, Hagler DJ, Dale AM, Elman JA, McEvoy LK, Eyler LT, Fennema-Notestine C, Logue MW, McKenzie RE, Puckett OK, Tu XM, Whitsel N, Xian H, Reynolds CA, Panizzon MS, Lyons MJ, Neale MC, Kremen WS, Franz C. The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years. Front Aging Neurosci. 2022; 14:831002. PMID: 35493948; PMCID: PMC9051484; DOI: 10.3389/fnagi.2022.831002;
     
  3. Sarnowski C, Ghanbari M, Bis JC, Logue M, Fornage M, Mishra A, Ahmad S, Beiser AS, Boerwinkle E, Bouteloup V, Chouraki V, Cupples LA, Damotte V, DeCarli CS, DeStefano AL, Djoussé L, Fohner AE, Franz CE, Kautz TF, Lambert JC, Lyons MJ, Mosley TH, Mukamal KJ, Pase MP, Portilla Fernandez EC, Rissman RA, Satizabal CL, Vasan RS, Yaqub A, Debette S, Dufouil C, Launer LJ, Kremen WS, Longstreth WT, Ikram MA, Seshadri S. Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels. Commun Biol. 2022 Apr 08; 5(1):336.View Related Profiles. PMID: 35396452; PMCID: PMC8993877; DOI: 10.1038/s42003-022-03287-y;
     
  4. Hawn SE, Neale Z, Wolf EJ, Zhao X, Pierce M, Fein-Schaffer D, Milberg W, McGlinchey R, Logue M, Miller MW. Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers. Depress Anxiety. 2022 Apr; 39(4):323-333.View Related Profiles. PMID: 35312143; PMCID: PMC8996332; DOI: 10.1002/da.23247;
     
  5. Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Sep; 7(9):935-948. PMID: 35307575
     
  6. Gustavson DE, Reynolds CA, Hohman TJ, Jefferson AL, Elman JA, Panizzon MS, Neale MC, Logue MW, Lyons MJ, Franz CE, Kremen WS. Alzheimer's Disease Polygenic Scores Predict Changes in Episodic Memory and Executive Function Across 12 Years in Late Middle Age. J Int Neuropsychol Soc. 2022 Feb 21; 1-12. PMID: 35184795; PMCID: PMC9392810; DOI: 10.1017/S1355617722000108;
     
  7. Katrinli S, Maihofer AX, Wani AH, Pfeiffer JR, Ketema E, Ratanatharathorn A, Baker DG, Boks MP, Geuze E, Kessler RC, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Logue MW, Nievergelt CM, Smith AK, Uddin M. Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress. Mol Psychiatry. 2022 Mar; 27(3):1720-1728. PMID: 34992238; PMCID: PMC9106882; DOI: 10.1038/s41380-021-01398-2;
     
  8. Zheng Y, Garrett ME, Sun D, Clarke-Rubright EK, Haswell CC, Maihofer AX, Elman JA, Franz CE, Lyons MJ, Kremen WS, Peverill M, Sambrook K, McLaughlin KA, Davenport ND, Disner S, Sponheim SR, Andrew E, Korgaonkar M, Bryant R, Varkevisser T, Geuze E, Coleman J, Beckham JC, Kimbrel NA, Sullivan D, Miller M, Hayes J, Verfaellie M, Wolf E, Salat D, Spielberg JM, Milberg W, McGlinchey R, Dennis EL, Thompson PM, Medland S, Jahanshad N, Nievergelt CM, Ashley-Koch AE, Logue MW, Morey RA. Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume. Transl Psychiatry. 2021 12 16; 11(1):637.View Related Profiles. PMID: 34916497; PMCID: PMC8677780; DOI: 10.1038/s41398-021-01707-x;
     
  9. Hersh SW, You Y, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058592.View Related Profiles. PMID: 34971140; DOI: 10.1002/alz.058592;
     
  10. Eglit GML, Elman JA, Panizzon MS, Sanderson-Cimino M, Williams ME, Dale AM, Eyler LT, Fennema-Notestine C, Gillespie NA, Gustavson DE, Hatton SN, Hagler DJ, Hauger RL, Jak AJ, Logue MW, McEvoy LK, McKenzie RE, Neale MC, Puckett O, Reynolds CA, Toomey R, Tu XM, Whitsel N, Xian H, Lyons MJ, Franz CE, Kremen WS. Paradoxical cognitive trajectories in men from earlier to later adulthood. Neurobiol Aging. 2022 01; 109:229-238. PMID: 34785406; PMCID: PMC8715388; DOI: 10.1016/j.neurobiolaging.2021.10.002;
     
Showing 10 of 126 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 126 publications over 23 distinct years, with a maximum of 15 publications in 2017 and 2020

YearPublications
19981
20011
20022
20032
20043
20053
20062
20071
20081
20091
20101
20114
20127
20138
20147
20159
20164
201715
20189
201910
202015
202113
20227

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
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72 E. Concord St Instructional (L)
Boston MA 02118
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