Mark W. Logue, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

PhD, University of Iowa
MS, University of Iowa




My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Associate Professor
Boston University School of Public Health
Biostatistics


VA Boston Healthcare System




The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2020 (PI)
Emory University NIH NIMH
5R01MH108826-03

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2018 - 07/31/2019 (PI)
Duke University NIH NIMH
5R01MH111671-02

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
09/06/2017 - 07/31/2018 (PI)
Duke University NIH NIMH
1R01MH111671-01A1

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05




Yr Title Project-Sub Proj Pubs
2019 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 1I01BX004192-01A1
2019 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-03 3
2019 The impact of traumatic stress on the methylome: implications for PTSD 5R01MH108826-04 6
2018 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-02 6
2018 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-02 3
2018 The impact of traumatic stress on the methylome: implications for PTSD 5R01MH108826-03 6
2017 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 1R01MH111671-01A1 6
2017 Genetic and Epigenetic Biomarkers of PTSD 1I01BX003477-01A1 3
2017 The impact of traumatic stress on the methylome: implications for PTSD 5R01MH108826-02 6
2016 The impact of traumatic stress on the methylome: implications for PTSD 1R01MH108826-01 6
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Zhou Z, Lunetta KL, Smith AK, Wolf EJ, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Miller MW, Logue MW. Correction for multiple testing in candidate-gene methylation studies. Epigenomics. 2019 Jul; 11(9):1089-1105.View Related Profiles. PMID: 31240951.
     
  2. Sullivan DR, Logue M, Wolf EJ, Hayes JP, Salat D, Fortier CB, Fonda JR, McGlinchey R, Milberg W, Miller MW. Close-range blast exposure is associated with altered white matter integrity in APOE e4 carriers. J Neurotrauma. 2019 Jun 22.View Related Profiles. PMID: 31232163.
     
  3. Elman JA, Panizzon MS, Logue MW, Gillespie NA, Neale MC, Reynolds CA, Gustavson DE, Rana BK, Andreassen OA, Dale AM, Franz CE, Lyons MJ, Kremen WS. Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment. Neurobiol Aging. 2019 Jun 08. PMID: 31272697.
     
  4. Morrison FG, Logue MW, Guetta R, Maniates H, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Miller MW, Wolf EJ. Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome. Aging (Albany NY). 2019 Jun 07; 11(11):3487-3504.View Related Profiles. PMID: 31173577.
     
  5. Polimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study. JAMA Netw Open. 2019 May 03; 2(5):e193447. PMID: 31050786.
     
  6. Wolf EJ, Morrison FG, Sullivan DR, Logue MW, Guetta RE, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Miller MW. The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging. Brain Behav Immun. 2019 Mar 11.View Related Profiles. PMID: 30872092.
     
  7. Morrison FG, Miller MW, Logue MW, Assef M, Wolf EJ. DNA methylation correlates of PTSD: Recent findings and technical challenges. Prog Neuropsychopharmacol Biol Psychiatry. 2019 03 02; 90:223-234.View Related Profiles. PMID: 30503303; DOI: 10.1016/j.pnpbp.2018.11.011;.
     
  8. Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019 01 23; 692:204-209.View Related Profiles. PMID: 30366016.
     
  9. Connolly SL, Stoop TB, Logue MW, Orr EH, De Vivo I, Miller MW, Wolf EJ. Posttraumatic Stress Disorder Symptoms, Temperament, and the Pathway to Cellular Senescence. J Trauma Stress. 2018 Oct; 31(5):676-686.View Related Profiles. PMID: 30338579.
     
  10. Sadeh N, Spielberg JM, Logue MW, Hayes JP, Wolf EJ, McGlinchey RE, Milberg WP, Schichman SA, Stone A, Miller MW. Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing. Psychol Med. 2018 Sep 12; 1-9.View Related Profiles. PMID: 30207258.
     
Showing 10 of 87 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 87 publications over 20 distinct years, with a maximum of 15 publications in 2017

YearPublications
19981
20011
20022
20032
20043
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20062
20071
20081
20091
20101
20114
20127
20138
20147
20159
20164
201715
20189
20196
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
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72 E. Concord St Instructional (L)
Boston MA 02118
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