Mark W. Logue, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

PhD, University of Iowa
MS, University of Iowa




My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Associate Professor
Boston University School of Public Health
Biostatistics


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


VA Boston Healthcare System


Member
Boston University
Genome Science Institute




The impact of traumatic stress on the methylome: implications for PTSD
08/21/2020 - 05/31/2025 (Subcontract PI)
Emory University NIH NIMH
2R01MH108826-05A1

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2019 - 07/31/2021 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-04

The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2020 (Subcontract PI)
Emory University NIH NIMH
5R01MH108826-04

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
08/01/2018 - 07/31/2019 (Subcontract PI)
Duke University NIH NIMH
5R01MH111671-02

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
09/06/2017 - 07/31/2018 (Subcontract PI)
Duke University NIH NIMH
1R01MH111671-01A1

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05



Title
The Impact of Traumatic Stress on the Methylome: Implications for PTSD
Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders
Early cognitive Impairment as a Function of Alzheimer's Disease Genes and Trauma
Genetic and Epigenetic Biomarkers of PTSD


Yr Title Project-Sub Proj Pubs
2021 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-03
2021 The Impact of Traumatic Stress on the Methylome: implications for PTSD 5R01MH108826-06 7
2020 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 5I01BX004192-02
2020 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-04 11
2020 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-04 8
2020 The Impact of Traumatic Stress on the Methylome: implications for PTSD 2R01MH108826-05A1 7
2019 Early Cognitive Impairment as a Function of Alzheimer?s Disease Genes and Trauma 1I01BX004192-01A1
2019 Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders 5R01MH111671-03 11
2019 Genetic and Epigenetic Biomarkers of PTSD 5I01BX003477-03 8
2019 The impact of traumatic stress on the methylome: implications for PTSD 5R01MH108826-04 7
Showing 10 of 22 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Wolf EJ, Zhao X, Hawn SE, Morrison FG, Zhou Z, Fein-Schaffer D, Huber B, Miller MW, Logue MW. Gene expression correlates of advanced epigenetic age and psychopathology in postmortem cortical tissue. Neurobiol Stress. 2021 Nov; 15:100371.View Related Profiles. PMID: 34458511; PMCID: PMC8377489; DOI: 10.1016/j.ynstr.2021.100371;
     
  2. Williams ME, Elman JA, McEvoy LK, Andreassen OA, Dale AM, Eglit GML, Eyler LT, Fennema-Notestine C, Franz CE, Gillespie NA, Hagler DJ, Hatton SN, Hauger RL, Jak AJ, Logue MW, Lyons MJ, McKenzie RE, Neale MC, Panizzon MS, Puckett OK, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Whitsel N, Xian H, Kremen WS. 12-year prediction of mild cognitive impairment aided by Alzheimer's brain signatures at mean age 56. Brain Commun. 2021; 3(3):fcab167. PMID: 34396116; PMCID: PMC8361427; DOI: 10.1093/braincomms/fcab167;
     
  3. Moody JN, Valerio KE, Hasselbach AN, Prieto S, Logue MW, Hayes SM, Hayes JP. Body Mass Index and Polygenic Risk for Alzheimer's Disease Predict Conversion to Alzheimer's Disease. J Gerontol A Biol Sci Med Sci. 2021 07 13; 76(8):1415-1422.View Related Profiles. PMID: 33880516; PMCID: PMC8277084; DOI: 10.1093/gerona/glab117;
     
  4. Sumner JA, Maihofer AX, Michopoulos V, Rothbaum AO, Almli LM, Andreassen OA, Ashley-Koch AE, Baker DG, Beckham JC, Bradley B, Breen G, Coleman JRI, Dale AM, Dennis MF, Feeny NC, Franz CE, Garrett ME, Gillespie CF, Guffanti G, Hauser MA, Hemmings SMJ, Jovanovic T, Kimbrel NA, Kremen WS, Lawford BR, Logue MW, Lori A, Lyons MJ, Maples-Keller J, Mavissakalian MR, McGlinchey RE, Mehta D, Mellor R, Milberg W, Miller MW, Morris CP, Panizzon MS, Ressler KJ, Risbrough VB, Rothbaum BO, Roy-Byrne P, Seedat S, Smith AK, Stevens JS, van den Heuvel LL, Voisey J, Young RM, Zoellner LA, Nievergelt CM, Wolf EJ. Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis. Front Neurosci. 2021; 15:678503.View Related Profiles. PMID: 34248484; PMCID: PMC8262489; DOI: 10.3389/fnins.2021.678503;
     
  5. Wooten T, Brown E, Sullivan DR, Logue MW, Fortier CB, Fonda JR, DeGutis J, Salat DH, McGlinchey R, Milberg W, Esterman M. Apolipoprotein E (APOE) e4 moderates the relationship between c-reactive protein, cognitive functioning, and white matter integrity. Brain Behav Immun. 2021 07; 95:84-95.View Related Profiles. PMID: 33631288
     
  6. Elman JA, Puckett OK, Beck A, Fennema-Notestine C, Cross LK, Dale AM, Eglit GML, Eyler LT, Gillespie NA, Granholm EL, Gustavson DE, Hagler DJ, Hatton SN, Hauger R, Jak AJ, Logue MW, McEvoy LK, McKenzie RE, Neale MC, Panizzon MS, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Whitsel N, Williams ME, Xian H, Lyons MJ, Franz CE, Kremen WS. MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction. Alzheimers Dement. 2021 06; 17(6):1017-1025. PMID: 33580733; PMCID: PMC8248066; DOI: 10.1002/alz.12261;
     
  7. Ditmars HL, Logue MW, Toomey R, McKenzie RE, Franz CE, Panizzon MS, Reynolds CA, Cuthbert KN, Vandiver R, Gustavson DE, Eglit GML, Elman JA, Sanderson-Cimino M, Williams ME, Andreassen OA, Dale AM, Eyler LT, Fennema-Notestine C, Gillespie NA, Hauger RL, Jak AJ, Neale MC, Tu XM, Whitsel N, Xian H, Kremen WS, Lyons MJ. Associations between depression and cardiometabolic health: A 27-year longitudinal study. Psychol Med. 2021 Jan 12; 1-11. PMID: 33431106
     
  8. Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113.View Related Profiles. PMID: 33074286; PMCID: PMC7573798; DOI: 10.1001/jamaneurol.2020.3536;
     
  9. Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O'Leary BM, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Luan Phan K, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Mol Psychiatry. 2020 Dec 07. PMID: 33288872; PMCID: PMC8180531; DOI: 10.1038/s41380-020-00967-1;
     
  10. Smith AK, Ratanatharathorn A, Maihofer AX, Naviaux RK, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Boks MP, Bromet E, Dennis M, Galea S, Garrett ME, Geuze E, Guffanti G, Hauser MA, Katrinli S, Kilaru V, Kessler RC, Kimbrel NA, Koenen KC, Kuan PF, Li K, Logue MW, Lori A, Luft BJ, Miller MW, Naviaux JC, Nugent NR, Qin X, Ressler KJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Wang L, Youssef NA, Uddin M, Nievergelt CM. Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR. Nat Commun. 2020 11 24; 11(1):5965.View Related Profiles. PMID: 33235198; PMCID: PMC7686485; DOI: 10.1038/s41467-020-19615-x;
     
Showing 10 of 114 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 114 publications over 22 distinct years, with a maximum of 15 publications in 2017 and 2020

YearPublications
19981
20011
20022
20032
20043
20053
20062
20071
20081
20091
20101
20114
20127
20138
20147
20159
20164
201715
20189
201910
202015
20218

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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