Haya Herscovitz | Profiles RNS

Haya Herscovitz, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Tel Aviv University (TAU)
MSc, Tel Aviv University (TAU)
BSc, Tel Aviv University (TAU)

Expertise includes biochemistry and cell biology.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

ApoB Folding and Secretion: Characterizing Helper Proteins
08/01/1997 - 06/30/2001 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL58833 04

Title

Yr	Title	Project-Sub Proj	Pubs
2010	Biochemistry and Protein Techniques	5P01HL026335-30-9002	235
2009	Biochemistry and Protein Techniques	5P01HL026335-29-9002	235
2008	CHAPERONES INVOLVED IN FOLDING OF APOB AND APOB COMPLEXES	5P41RR010888-12-5186	259
2008	Biochemistry and Protein Techniques	5P01HL026335-28-9002	235
2007	CHAPERONES INVOLVED IN FOLDING OF APOB AND APOB COMPLEXES	2P41RR010888-11-8007	259
2006	CHAPERONES INVOLVED IN FOLDING OF APOB AND APOB COMPLEXES	5P41RR010888-10-7088	259
2006	Biochemistry and Protein Techniques	2P01HL026335-26-9002	235
2005	CHAPERONES INVOLVED IN FOLDING OF APOB AND APOB COMPLEXES	5P41RR010888-09-120	259
2004	CHAPERONES INVOLVED IN FOLDING OF APOB	5P41RR010888-08-120	259
2000	APOB FOLDING &SECRETION--CHARACTERIZING HELPER PROTEINS	5R01HL058833-04	4

Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Gorshkova IN, Meyers NL, Herscovitz H, Mei X, Atkinson D. Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL. J Lipid Res. 2023 Feb; 64(2):100319.View Related Profiles.

Atkinson, David
Herscovitz, Haya
Gorshkova, Irina
Meyers, Nathan
Mei, Xiaohu

PMID: 36525992; PMCID: PMC9926306; DOI: 10.1016/j.jlr.2022.100319;

Ajjaji D, Ben M'barek K, Mimmack ML, England C, Herscovitz H, Dong L, Kay RG, Patel S, Saudek V, Small DM, Savage DB, Thiam AR. Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets. Mol Biol Cell. 2019 03 01; 30(5):703-716.View Related Profiles.

Small, Donald
Herscovitz, Haya

PMID: 30649995; PMCID: PMC6589688; DOI: 10.1091/mbc.E18-08-0534;

Liu M, Mei X, Herscovitz H, Atkinson D. N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis. J Lipid Res. 2019 01; 60(1):44-57.View Related Profiles.

Atkinson, David
Herscovitz, Haya
Liu, Minjing
Mei, Xiaohu

PMID: 30249788; PMCID: PMC6314262; DOI: 10.1194/jlr.M084376;

Mei X, Liu M, Herscovitz H, Atkinson D. Probing the C-terminal domain of lipid-free apoA-I demonstrates the vital role of the H10B sequence repeat in HDL formation. J Lipid Res. 2016 Aug; 57(8):1507-17.View Related Profiles.

Atkinson, David
Herscovitz, Haya
Liu, Minjing
Mei, Xiaohu

PMID: 27317763; PMCID: PMC4959866; DOI: 10.1194/jlr.M068874;

Lu M, Gantz DL, Herscovitz H, Gursky O. Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis. J Lipid Res. 2012 Oct; 53(10):2175-85.View Related Profiles.

Herscovitz, Haya
Lu, Mengxiao
Gursky, Olga

PMID: 22855737; PMCID: PMC3435550; DOI: 10.1194/jlr.M029629;

Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct; 7(10):e1000208.View Related Profiles.

Herscovitz, Haya
Delalle, Ivana
Xie, Zhigang

PMID: 19806181; PMCID: PMC2748697; DOI: 10.1371/journal.pbio.1000208;

Guha M, England C, Herscovitz H, Gursky O. Thermal transitions in human very-low-density lipoprotein: fusion, rupture, and dissociation of HDL-like particles. Biochemistry. 2007 May 22; 46(20):6043-9.View Related Profiles.

Herscovitz, Haya
Gursky, Olga

PMID: 17469851; PMCID: PMC2577769; DOI: 10.1021/bi7001532;

Sommer U, Herscovitz H, Welty FK, Costello CE. LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures. J Lipid Res. 2006 Apr; 47(4):804-14.View Related Profiles.

Costello, Catherine
Herscovitz, Haya

PMID: 16443931

Herrera VL, Tsikoudakis A, Didishvili T, Ponce LR, Bagamasbad P, Gantz D, Herscovitz H, Van Tol A, Ruiz-Opazo N. Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model. Atherosclerosis. 2004 Nov; 177(1):9-18.View Related Profiles.

Herscovitz, Haya
Ruiz-Opazo, Nelson
Herrera, Victoria

PMID: 15488860

Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem. 2004 Nov 12; 279(46):47898-905.View Related Profiles.

Herscovitz, Haya
Zang, Mengwei
Ruderman, Neil
Brecher, Peter
Cohen, Richard

PMID: 15371448

Showing 10 of 22 results. Show More

Zhang J, Herscovitz H. Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. J Biol Chem. 2003 Feb 28; 278(9):7459-68. PMID: 12397072

Herrera VM, Didishvili T, Lopez LV, Zander K, Traverse S, Gantz D, Herscovitz H, Ruiz-Opazo N. Hypertension exacerbates coronary artery disease in transgenic hyperlipidemic Dahl salt-sensitive hypertensive rats. Mol Med. 2001 Dec; 7(12):831-44.View Related Profiles.

Herscovitz, Haya
Ruiz-Opazo, Nelson
Herrera, Victoria

PMID: 11844871; PMCID: PMC1950013

Herscovitz H, Derksen A, Walsh MT, McKnight CJ, Gantz DL, Hadzopoulou-Cladaras M, Zannis V, Curry C, Small DM. The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins. J Lipid Res. 2001 Jan; 42(1):51-9.View Related Profiles.

McKnight, C.
Curry, Christine
Small, Donald
Herscovitz, Haya
Zannis, Vassilis

PMID: 11160365

Carraway M, Herscovitz H, Zannis V, Small DM. Specificity of lipid incorporation is determined by sequences in the N-terminal 37 of apoB. Biochemistry. 2000 Aug 15; 39(32):9737-45.View Related Profiles.

Small, Donald
Herscovitz, Haya
Carraway, Margaretha
Zannis, Vassilis

PMID: 10933790

Burch WL, Herscovitz H. Disulfide bonds are required for folding and secretion of apolipoprotein B regardless of its lipidation state. J Biol Chem. 2000 May 26; 275(21):16267-74. PMID: 10747912

Linnik KM, Herscovitz H. Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. J Biol Chem. 1998 Aug 14; 273(33):21368-73. PMID: 9694898

Herscovitz H, Kritis A, Talianidis I, Zanni E, Zannis V, Small DM. Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):659-63.View Related Profiles.

Small, Donald
Zanni, Eleni
Herscovitz, Haya
Zannis, Vassilis

PMID: 7846033; PMCID: PMC42679

Meshulam T, Herscovitz H, Casavant D, Bernardo J, Roman R, Haugland RP, Strohmeier GS, Diamond RD, Simons ER. Flow cytometric kinetic measurements of neutrophil phospholipase A activation. J Biol Chem. 1992 Oct 25; 267(30):21465-70.View Related Profiles.

Simons, Elizabeth
Herscovitz, Haya
Bernardo, John
Meshulam, Tova

PMID: 1400459

Herscovitz H, Gantz D, Tercyak AM, Zannis VI, Small DM. Expression of human apolipoprotein E but not that of apolipoprotein A-I by mouse C127 cells is associated with increased secretion of lipids in the form of vesicles and discs. J Lipid Res. 1992 Jun; 33(6):791-803.View Related Profiles.

Small, Donald
Herscovitz, Haya
Zannis, Vassilis

PMID: 1512507

Zoeller RA, Rangaswamy S, Herscovitz H, Rizzo WB, Hajra AK, Das AK, Moser HW, Moser A, Lazarow PB, Santos MJ. Mutants in a macrophage-like cell line are defective in plasmalogen biosynthesis, but contain functional peroxisomes. J Biol Chem. 1992 Apr 25; 267(12):8299-306.View Related Profiles.

Herscovitz, Haya
Zoeller, Raphael

PMID: 1569085

Herscovitz H, Hadzopoulou-Cladaras M, Walsh MT, Cladaras C, Zannis VI, Small DM. Expression, secretion, and lipid-binding characterization of the N-terminal 17% of apolipoprotein B. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7313-7.View Related Profiles.

Small, Donald
Herscovitz, Haya
Zannis, Vassilis

PMID: 1871138; PMCID: PMC52285

Herscovitz H, Ronen I, Bilu S, Tietz A. Bile acid synthesis from HDL cholesterol and cholesterol ester by cultured chick embryo hepatocytes. Biochim Biophys Acta. 1986 Oct 3; 878(3):426-34. PMID: 3756203

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 22 publications over 17 distinct years, with a maximum of 3 publications in 1992

Bar chart showing 22 publications over 17 distinct years, with a maximum of 3 publications in 1992

Year	Publications
1986	1
1991	1
1992	3
1995	1
1998	1
2000	2
2001	2
2002	1
2004	2
2006	1
2007	1
2009	1
2012	1
2016	1
2018	1
2019	1
2022	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

apolipoproteins
cholesterol
fatty acids
HDL
LDL
lipoproteins
molecular chaperones
resveratrol
SIRT1
transcription factors
triglycerides
VLDL

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Google Map

617.638.4012

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