Keywords
Last Name

Irina N. Gorshkova, PhD

TitleSenior Research Scientist
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
DivisionCardiovascular Medicine
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-4207
ORCID ORCID Icon0000-0001-7731-302X
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gorshkova IN, Mei X, Atkinson D. Binding of human apoA-I[K107del] variant to TG-rich particles: implications for mechanisms underlying hypertriglyceridemia. J Lipid Res. 2014 Sep; 55(9):1876-85. PMID: 24919401.
    View in: PubMed
  2. Kateifides AK, Gorshkova IN, Duka A, Chroni A, Kardassis D, Zannis VI. Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL. J Lipid Res. 2011 Jul; 52(7):1363-72. PMID: 21504968.
    View in: PubMed
  3. Gorshkova IN, Atkinson D. Enhanced binding of apolipoprotein A-I variants associated with hypertriglyceridemia to triglyceride-rich particles. Biochemistry. 2011 Mar 29; 50(12):2040-7. PMID: 21288012.
    View in: PubMed
  4. Gorshkova IN, Kypreos KE, Gantz DL, Zannis VI, Atkinson D. Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia. Biochemistry. 2008 Nov 25; 47(47):12644-54. PMID: 18959431.
    View in: PubMed
  5. Gorshkova IN, Liu T, Kan HY, Chroni A, Zannis VI, Atkinson D. Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation. Biochemistry. 2006 Jan 31; 45(4):1242-54. PMID: 16430220.
    View in: PubMed
  6. Chroni A, Kan HY, Kypreos KE, Gorshkova IN, Shkodrani A, Zannis VI. Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice. Biochemistry. 2004 Aug 17; 43(32):10442-57. PMID: 15301543.
    View in: PubMed
  7. Chroni A, Liu T, Gorshkova I, Kan HY, Uehara Y, Von Eckardstein A, Zannis VI. The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo. J Biol Chem. 2003 Feb 28; 278(9):6719-30. PMID: 12488454.
    View in: PubMed
  8. Gorshkova IN, Liu T, Zannis VI, Atkinson D. Lipid-free structure and stability of apolipoprotein A-I: probing the central region by mutation. Biochemistry. 2002 Aug 20; 41(33):10529-39. PMID: 12173940.
    View in: PubMed
  9. Gorshkova IN, Liadaki K, Gursky O, Atkinson D, Zannis VI. Probing the lipid-free structure and stability of apolipoprotein A-I by mutation. Biochemistry. 2000 Dec 26; 39(51):15910-9. PMID: 11123918.
    View in: PubMed
  10. Gorshkova IN, Menschikowski M, Jaross W. Alterations in the physiochemical characteristics of low and high density lipoproteins after lipolysis with phospholipase A2. A spin-label study. Biochim Biophys Acta. 1996 Apr 19; 1300(2):103-13. PMID: 8652635.
    View in: PubMed
  11. Gorshkova IN, Kiseleva NG, Akhmedzhanov NM, Perova NV. [Effect of enduracin on the activity of a cholesterol ester transfer protein in blood plasma of people with hypercholesteremia]. Biull Eksp Biol Med. 1996 Feb; 121(2):185-7. PMID: 9026127.
    View in: PubMed
  12. Jaross W., Menschikowski M., Gorshkova IN, Kasper M. . The modification of lipoproteins by phospholipase A2 and their possible implication in the pathogenesis of atherosclerosis. “Advances in Lipoprotein and Atherosclerosis Research, Diagnostics and Treatment” (ed. Jaross W.). G. Fisher,. Jena-Stuttgart-New York. 1995; 34-41.
  13. Gorshkova IN, Shchukina GN, Morozkin AD, Sokolova MA, Ruuge EK, Perova NV, Sokolov EI, Oganov RG. [Changes in the physicochemical characteristics of low-density lipoproteins following a single fat load]. Fiziol Cheloveka. 1991 Nov-Dec; 17(6):119-25. PMID: 1668235.
    View in: PubMed
  14. Medvedeva NV, Morozkin AD, Valentinova NV, Scherbakova IA, Gorshkova IN, Perova NV, Lyakishev AA, Ruuge EK. Low density lipoproteins flotation mass-spectra, surface particle potential and plasma lipid composition in some dyslipoproteinemias. CV World Report. Miranda Communications GmbH. 1991; 4:102-108.
  15. Sediuk AP, Shakhov IuA, Konstantinov VV, Gorshkova IN, Sokolova MA. [Changes in high density lipoprotein subfractions during interaction with fibroblasts and hepatoma G-2 in various dyslipidemias]. Vopr Med Khim. 1990 Sep-Oct; 36(5):48-53. PMID: 2174587.
    View in: PubMed
  16. Shakhov YuA, Kolpakova GV, Gorshkova IN, Serdyuk AP, Larrue J, Ruuge EK, Perova NV. . Reduced ability of high density lipoproteins to accept cellular cholesterol in hypoalphacholesterolemia. Biol. Mem. 1990; 4:947-959.
  17. Shakhov IuA, Petrichenko IE, Gorshkova IN, Perova NV, Oganov RG. [Low-density lipoproteins decrease cell sensitivity to glucocorticoids]. Dokl Akad Nauk SSSR. 1990; 313(4):1003-6. PMID: 2174767.
    View in: PubMed
  18. Medvedeva NV, Morozkin AD, Goroshkova IN, Ruuge EK, Shcherbakova IA. [Low density lipoprotein distribution by flotation characteristics in normal conditions and in dyslipoproteinemias]. Vopr Med Khim. 1989 May-Jun; 35(3):36-41. PMID: 2773382.
    View in: PubMed
  19. Gorshkova IN, Noeva EA, Polesskii VA, Perova NV, Ruuge EK. [A study of thermoinduced changes in human high-density lipoproteins in hypo-alpha-lipoproteinemia and ischemic heart disease by the spin label method]. Vopr Med Khim. 1988 May-Jun; 34(3):85-90. PMID: 2844020.
    View in: PubMed
  20. Gorshkova IN, Medvedeva NV, Morozkin AD, Fuki IV, Gorchakova NN. [Physico-chemical and functional characteristics of a subfraction of low-density lipoproteins isolated by ion-exchange column chromatography]. Biokhimiia. 1988 Apr; 53(4):687-93. PMID: 3395647.
    View in: PubMed
  21. Ruuge EK, Gorshkova IN, Perova NV. . Physicochemical properties of high density lipoproteins in patients with hypoalphalipoproteinemia: spin-labels study. Soc Med Rev A Cardiol. 1987; 387-405.
  22. Ruuge EK., Gorshkova IN, Martsenyuk OV, Noeva EA. . Physicochemical properties of high density lipoproteins in dislipoproteinemias: risk-factors of coronary heart disease. News in Cardiology (Russ.), Ed. Chazov EI. Medicine. Moscow. 1985; 118-122.
  23. El'-Karadagi S, Ruuge EK, Tverdislov VA, Iuzhakov VI, Gorshkova IN. [Localization of tryptophanyl residues in the low-density lipoproteins of human plasma based on fluorescence paramagnetic quenching data]. Biofizika. 1983 Mar-Apr; 28(2):343-4. PMID: 6303453.
    View in: PubMed
  24. Belaia ML, El'-Karadagi S, Gorshkova IN, Tverdislov VA. [Interaction between plasma lipoproteins and bilayer lipid membranes. The role of surface charge]. Biofizika. 1983 Mar-Apr; 28(2):254-9. PMID: 6303446.
    View in: PubMed
  25. Ruuge EK, Gerasimova EN, Gorshkova IN, Perova NV. . Studies of subfractions of high density lipoprotein by spin labels. High Density Lipoproteins and Atherosclerosis. Ed. Klimov A.N. and Levy R.I. Medicine. Moscow. 1983; 103-113.
  26. Ruuge EK, Gerasimova EN, Gorshkova IN, Perova NV. . Study of HDL subclasses by spin-label method. USA-USSR First Lipoprotein Symposium. U.S. Dept. of Health and Human Services, NIH. 1982; 123-136.
  27. Gorshkova IN, Perova NV, Ruuge EK, Lobova NM, Polesskii VA. [Spin label analysis of subclasses of high density lipoproteins]. Vopr Med Khim. 1982 Jan-Feb; 28(1):106-13. PMID: 6278761.
    View in: PubMed
  28. Kharitonenkov IG, Gorshkova IN, Ruuge EK. [Covalent fixation of a spin label containing a free amino group on protein molecules]. Biofizika. 1979 Sep-Oct; 24(5):927-9. PMID: 226174.
    View in: PubMed
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