Susan E. Leeman, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Radcliffe College
MA, Radcliffe College
BA, Goucher College



Dr. Susan Leeman is a Professor in the Department of Pharmacology & Experimental Therapeutics, and the Director of the Neuropeptide Laboratory in the Pharmacology Department at the Chobanian and Avedisian School of Medicine. Dr. Leeman has been a Member of the National Academy of Sciences since 1991.

Dr. Leeman’s research focuses on the two peptides, substance P (SP) and neurotensin, that were isolated and chemically defined in this laboratory. Previous projects that are currently underway relating to the biochemistry and pharmacology of SP include studies to determine the binding domains of SP with its receptor using photoactivatable derivatives of SP containing the photoreactive amino acid benzoylphenlalanine; studies to determine the binding domains of an antagonist of SP, CP 96,345 using a photoactivatable derivative of this compound; the characterization of calcium signals generated by administration of SP to CHO cells transfected with mRNA encoding the full-length SP receptor; the roles of SP in several models of inflammation in the gastrointestinal tract using non-peptide SP antagonists; a truncated form of the SP receptor and several mutant receptors. A new direction of research involves studies directed towards the chemical characterization and function of the carbohydrate moieties on the SP receptor.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Glycosylation of NK1 Receptors: Chemistry and Function
04/01/2003 - 09/30/2005 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5 R21 NS43228 02



Title


Yr Title Project-Sub Proj Pubs
2008 CHARACTERIZATION OF GLYCOSYLATION PATTERN OF NK1 RECEPTOR 5P41RR010888-12-5188 259
2007 CHARACTERIZATION OF GLYCOSYLATION PATTERN OF NK1 RECEPTOR 2P41RR010888-11-8009 259
2006 CHARACTERIZATION OF GLYCOSYLATION PATTERN OF NK1 RECEPTOR 5P41RR010888-10-7093 259
2005 CHARACTERIZATION OF GLYCOSYLATION PATTERN OF NK1 RECEPTOR 5P41RR010888-09-128 259
2004 CHARACTERIZATION OF GLYCOSYLATION PATTERN OF NK1 RECEPTOR 5P41RR010888-08-128 259
2004 Glycosylation of NK1 Receptors: Chemistry and Function 5R21NS043228-02
2003 Glycosylation of NK1 Receptors: Chemistry and Function 1R21NS043228-01A1
1995 NEUROTENSIN AND FEMALE-SPECIFIC LH SECRETION 5R01DK029876-16 21
1994 MOLECULAR BIOLOGICAL STUDIES ON PEPTIDE 1F15TW000366-01 2
1994 NEUROTENSIN AND FEMALE-SPECIFIC LH SECRETION 5R01DK029876-15 21
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dent G, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Herr D, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Lolait SJ, Lupp A, Macrae R, Maguire J, Malfacini D, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy PM, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Smith CM, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Toll L, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Williams TL, Woodruff TM, Yao C, Ye RD. The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 2023 Oct; 180 Suppl 2:S23-S144. PMID: 38123151
     
  2. Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu JM, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Woodruff TM, Yao C, Ye RD. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S27-S156. PMID: 34529832
     
  3. Tsilioni I, Pantazopoulos H, Conti P, Leeman SE, Theoharides TC. IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16475-16480. PMID: 32601180; PMCID: PMC7368277; DOI: 10.1073/pnas.2004666117;
     
  4. Tsilioni I, Patel AB, Pantazopoulos H, Berretta S, Conti P, Leeman SE, Theoharides TC. IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21659-21665. PMID: 31591201; PMCID: PMC6815178; DOI: 10.1073/pnas.1906817116;
     
  5. Theoharides TC, Leeman SE. Effect of IL-33 on de novo synthesized mediators from human mast cells. J Allergy Clin Immunol. 2019 01; 143(1):451. PMID: 30390921
     
  6. Taracanova A, Tsilioni I, Conti P, Norwitz ER, Leeman SE, Theoharides TC. Substance P and IL-33 administered together stimulate a marked secretion of IL-1ß from human mast cells, inhibited by methoxyluteolin. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9381-E9390. PMID: 30232261; PMCID: PMC6176605; DOI: 10.1073/pnas.1810133115;
     
  7. Douglas SD, Leeman SE. Is substance P a nasal epithelial neuropeptide? J Allergy Clin Immunol. 2018 11; 142(5):1677. PMID: 29958676
     
  8. Theoharides TC, Taracanova A, Tsilioni I, Conti P, Leeman SE. Reply to Fattori et al.: Action of SP and IL-33 on mast cells. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10036. PMID: 29109296; PMCID: PMC5703332; DOI: 10.1073/pnas.1716233114;
     
  9. Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4002-E4009. PMID: 28461492; PMCID: PMC5441798; DOI: 10.1073/pnas.1524845114;
     
  10. Patel AB, Tsilioni I, Leeman SE, Theoharides TC. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):E7049-E7058. PMID: 27663735; PMCID: PMC5111711; DOI: 10.1073/pnas.1604992113;
     
Showing 10 of 224 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 169 publications over 41 distinct years, with a maximum of 13 publications in 1980

YearPublications
198013
19818
198210
19833
19846
19856
19865
19875
19884
19896
19902
19918
19924
19932
19944
19956
199610
19974
19984
19991
20005
20013
20021
20032
20042
20051
20063
20078
20087
20091
20103
20117
20122
20133
20161
20172
20183
20191
20201
20211
20231


Inflammation and autism-an important piece of the puzzle

Medical Xpress 10/22/2019

2006 American Association for the Advancement of Science: Fellow
2005 Mika Salpeter Lifetime Achievement Award, Women in Neuroscience
1999 14th Annual Isadore Rosenberg Lecture
1994 Fogarty Scholar-in-Residence
1994 Fred Conrad Koch Award
1994 197th Lilly Lecture
1993 FASEB, Excellence in Science Award
1993 Goucher Gollege, Towson, Maryland: Honorary Degree
1992 State University of New York, Institute of Technology at Utica/Rome: Honorary Degree, Doctor of Science
1992 University of Kentucky: Burroughs Wellcome Visiting Professorship Award
1991 National Academy of Sciences: Member
1987 American Academy of Arts & Sciences: Fellow
1984 Boston Veterans Administration Medical Center: Charles C. Pinderhughes Lecture
1984 Mt. Holyoke College: Christianna Smith Lecture
1983 New York Academy of Sciences: The Louis and Bert Freedman Foundation Award for Research in Biochemistry
1983 Texas Tech University: Distinguished Neuroscientist, Tarbox Lecture Series
1982 College of Physicians and Surgeons of Columbia University: Van Dyke Award
1981 The Endocrine Society: Astwood Award
1981 University of Calgary: Alberta Heritage for Medical Research Visiting Professor Award
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72 E. Concord St Building A
Boston MA 02118
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