Vickery Trinkaus-Randall

Vickery Trinkaus-Randall, PhD

Professor

Boston University School of Medicine

Dept of Biochemistry

PhD, University of Wisconsin Madison

Websites

	Biochemistry, Cell Biology & Genomics Faculty
	Ophthalmology Faculty
	ResearchGate
	LinkedIn

ORCID : 0000-0002-8573-9108

Our laboratory is interested in the wound response and repair of epithelium, neurons and extracellular matrix. 1. In the healthy cornea there are no blood vessels and thus the tissue provides an excellent model to study the communication between nerves and epithelium following injury. Primary neurons are co-cultured with epithelial cells to ask how signaling pathways communicate. These include but are not limited to glutamatergic and purinergic receptor-mediated calcium transients. 2. In addition to these signaling events we have found that when epithelial cells are injured nucleotides are released immediately and cause a distinct phosphorylation of EGF receptor residues that ultimately affect the ability of a cell to migrate. 3. To study controlling factors on extracellular matrix or stromal formation we have developed scaffold-free long-term cultures and these have recently enabled us to study the role of hypoxia, which occurs in a diurnal pattern in this tissue as one sleeps. Our experiments are conducted using a number of organ culture and cell models and use biochemical, cell and molecular techniques. 4. Last but not least we are interested in the role of long sugar chains or glycosaminoglycans on the formation of oligomers and fibrils in light chain amyloid disease using atomic force microscopy, negative staining and biochemical technologies.

Professor
Boston University School of Medicine
Ophthalmology

Co-Director
Boston University School of Medicine, Graduate Medical Sciences
MD/PhD Program

2013 GMS Faculty Recognition Award

2010 Gold Fellow of ARVO (Association for Research in Vision and Ophthalmology)

BU Sponsored Research
NIH RePORTER Sponsored Research

Calcium oscillations and cell motility with corneal injury
02/01/2019 - 01/31/2021 (PI)
NIH/National Eye Institute
1R21EY029097-01A1

Molecular Mechanisms of corneal wound repair
09/30/2018 - 09/29/2019 (PI)
NIH/National Eye Institute
2R01EY006000-31

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2019 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Corneal Epithelial Adhesion: Morphology and Biochemistry
08/01/2014 - 09/29/2018 (PI)
NIH/National Eye Institute
5R01EY006000-30

Multicellular Regulation of Corneal Wound Healing
12/01/2014 - 11/30/2017 (PI)
NIH/National Eye Institute
5R21EY024392-02

Corneal Epithelial Adhesion: Morphology & Biochemistry
06/01/1986 - 05/31/2014 (PI)
NIH/National Eye Institute
5R01EY006000-26

Engineering Biomimetric Corneal Constructs
09/30/2009 - 09/29/2011 (PI)
Northeastern University NIH NEI
5R01EY015500-06

Purchase of a New Confocal Zeiss LSM 510v3.2
09/01/2005 - 08/31/2006 (PI)
NIH/National Center for Health Research Resources
1 S10 RR17967 01A2

Role of Growth Factors on Epidermal and Neuronal Injury
09/30/2000 - 08/31/2003 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R21 DK59753 02

Regulation of Extracellular Matrix in the Corneal Stroma
08/01/1996 - 07/31/2000 (Co-PI)
PI: Matthew A. Nugent, PhD
NIH/National Eye Institute
5 R01 EY11004 04

Yr	Title	Project-Sub Proj	Pubs
2019	Calcium oscillations and cell motility with corneal injury	1R21EY029097-01A1
2018	Molecular Mechanisms of corneal wound repair	2R01EY006000-31	29
2017	Corneal Epithelial Adhesion: Morphology and Biochemistry	5R01EY006000-30	29
2016	Multicellular regulation of corneal wound healing	5R21EY024392-02
2016	Corneal Epithelial Adhesion: Morphology and Biochemistry	5R01EY006000-29	29
2015	Multicellular regulation of corneal wound healing	1R21EY024392-01A1
2015	Corneal Epithelial Adhesion: Morphology and Biochemistry	5R01EY006000-28	29
2015	Corneal Epithelial Adhesion: Morphology and Biochemistry	3R01EY006000-28S1	29
2014	Corneal Epithelial Adhesion: Morphology and Biochemistry	2R01EY006000-27A1	29
2012	Corneal epithelial adhesion:morphology and biochemistry	5R01EY006000-26	29

Showing 10 of 56 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles.
Gabel, Christopher
Trinkaus-Randall, Vickery
Kolachalama, Vijaya
PMID: 31017899.
Onochie OE, Onyejose AJ, Rich CB, Trinkaus-Randall V. The Role of Hypoxia in Corneal Extracellular Matrix Deposition and Cell Motility. Anat Rec (Hoboken). 2019 Mar 12.View Related Profiles.
Onochie, Obi
Trinkaus-Randall, Vickery
PMID: 30861330.
Onochie OE, Zollinger A, Rich CB, Smith M, Trinkaus-Randall V. Epithelial cells exert differential traction stress in response to substrate stiffness. Exp Eye Res. 2019 Apr; 181:25-37.View Related Profiles.
Onochie, Obi
Trinkaus-Randall, Vickery
PMID: 30653966.
Kneer K, Green MB, Meyer J, Rich CB, Minns MS, Trinkaus-Randall V. High fat diet induces pre-type 2 diabetes with regional changes in corneal sensory nerves and altered P2X7 expression and localization. Exp Eye Res. 2018 10; 175:44-55.View Related Profiles.
Minns, Martin
Trinkaus-Randall, Vickery
PMID: 29883639; DOI: 10.1016/j.exer.2018.06.001;.
Lee A, Karamichos D, Onochie OE, Hutcheon AEK, Rich CB, Zieske JD, Trinkaus-Randall V. Hypoxia modulates the development of a corneal stromal matrix model. Exp Eye Res. 2018 05; 170:127-137.View Related Profiles.
Onochie, Obi
Trinkaus-Randall, Vickery
PMID: 29496505.
Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 Sep; 31(9):4117-4128.View Related Profiles.
Barrios, Juliana
Patel, Kruti
Minns, Martin
Trinkaus-Randall, Vickery
Ai, Xingbin
Lee, Yoonjoo
PMID: 28566470.
Minns MS, Trinkaus-Randall V. Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors. J Ocul Pharmacol Ther. 2016 Oct; 32(8):498-503.View Related Profiles.
Minns, Martin
Trinkaus-Randall, Vickery
PMID: 27643999.
Minns MS, Teicher G, Rich CB, Trinkaus-Randall V. Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury. Am J Pathol. 2016 Feb; 186(2):285-96.View Related Profiles.
Minns, Martin
Trinkaus-Randall, Vickery
PMID: 26683661; PMCID: PMC4729273; DOI: 10.1016/j.ajpath.2015.10.006;.
Derricks KE, Trinkaus-Randall V, Nugent MA. Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb). 2015 Sep; 7(9):1011-25.View Related Profiles.
Derricks, Kelsey
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 26183123; PMCID: PMC4558347; DOI: 10.1039/c5ib00140d;.
Minns M, Teicher G, Rich CB, Trinkaus-Randall V. Experimental Biology Meeting. Inhibition of P2X7 Alters Wound-Induced Ca2+ Mobilization and Cytoskeletal Rearrangements. The FASEB Journal. 2015; 29.

Showing 10 of 110 results. Show More

Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Exp Eye Res. 2014 Oct; 127:270-9. PMID: 25151301; PMCID: PMC4175147; DOI: 10.1016/j.exer.2014.08.009;.
Karamichos D, Hutcheon AE, Rich CB, Trinkaus-Randall V, Asara JM, Zieske JD. In vitro model suggests oxidative stress involved in keratoconus disease. Sci Rep. 2014; 4:4608. PMID: 24714342; PMCID: PMC3980225; DOI: 10.1038/srep04608;.
Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, Trinkaus-Randall V. Hypoxia-induced changes in Ca(2+) mobilization and protein phosphorylation implicated in impaired wound healing. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C972-85.View Related Profiles.
Derricks, Kelsey
Minns, Martin
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 24671101; PMCID: PMC4024710; DOI: 10.1152/ajpcell.00110.2013;.
Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Exp Eye Res. 2014 Apr; 121:178-93. PMID: 24607489; PMCID: PMC4072315; DOI: 10.1016/j.exer.2014.02.007;.
Karamichos D, Rich CB, Zareian R, Hutcheon AE, Ruberti JW, Trinkaus-Randall V, Zieske JD. TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophthalmol Vis Sci. 2013 Oct; 54(10):6612-9. PMID: 24022012; PMCID: PMC3803138; DOI: 10.1167/iovs.13-12861;.
Kehasse A, Rich CB, Lee A, McComb ME, Costello CE, Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am J Pathol. 2013 Dec; 183(6):1841-52.View Related Profiles.
Costello, Catherine
McComb, Mark
Trinkaus-Randall, Vickery
PMID: 24095926; DOI: 10.1016/j.ajpath.2013.08.015;.
Chi C, Trinkaus-Randall V. New insights in wound response and repair of epithelium. J Cell Physiol. 2013 May; 228(5):925-9. PMID: 23129239; DOI: 10.1002/jcp.24268;.
Oswald DJ, Lee A, Trinidad M, Chi C, Ren R, Rich CB, Trinkaus-Randall V. Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors. PLoS One. 2012; 7(9):e44574.View Related Profiles.
Ren, Ruiyi
Trinkaus-Randall, Vickery
PMID: 22970252; PMCID: PMC3436752; DOI: 10.1371/journal.pone.0044574;.
Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnol Bioeng. 2012 Oct; 109(10):2683-98. PMID: 22528405; PMCID: PMC3757098; DOI: 10.1002/bit.24533;.
Mankus C, Chi C, Rich C, Ren R, Trinkaus-Randall V. The P2X(7) receptor regulates proteoglycan expression in the corneal stroma. Mol Vis. 2012; 18:128-38. PMID: 22275804; PMCID: PMC3265178.
Mankus C, Rich C, Minns M, Trinkaus-Randall V. Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. PLoS One. 2011; 6(12):e28541.View Related Profiles.
Minns, Martin
Trinkaus-Randall, Vickery
PMID: 22163032; PMCID: PMC3232242; DOI: 10.1371/journal.pone.0028541;.
Ward JE, Ren R, Toraldo G, Soohoo P, Guan J, O'Hara C, Jasuja R, Trinkaus-Randall V, Liao R, Connors LH, Seldin DC. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011 Dec 15; 118(25):6610-7.View Related Profiles.
O'Hara, Carl
Seldin, David
Toraldo, Gianluca
Ward, Jennifer
Connors, Lawreen
Ren, Ruiyi
Trinkaus-Randall, Vickery
PMID: 21998211; PMCID: PMC3242721; DOI: 10.1182/blood-2011-04-351643;.
Karamichos D, Rich CB, Hutcheon AE, Ren R, Saitta B, Trinkaus-Randall V, Zieske JD. Self-assembled matrix by umbilical cord stem cells. J Funct Biomater. 2011; 2(3):213-29.View Related Profiles.
Ren, Ruiyi
Trinkaus-Randall, Vickery
PMID: 24956304; DOI: 10.3390/jfb2030213;.
Boucher I, Kehasse A, Marcincin M, Rich C, Rahimi N, Trinkaus-Randall V. Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am J Pathol. 2011 Mar; 178(3):1092-105.View Related Profiles.
Rahimi, Nader
Trinkaus-Randall, Vickery
PMID: 21356361; PMCID: PMC3069885; DOI: 10.1016/j.ajpath.2010.11.060;.
Karamichos D, Rich C, Hutcheon A, Ren R, Saitta B, Trinkaus-Randall V, Zieske J. Self-Assembled Matrix by Umbilical Cord Stem Cells. J. Functional Biomaterials (special issue – Biomaterials in Wound Healing). 2011.
Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82.View Related Profiles.
Costello, Catherine
Seldin, David
Gong, Haiyan
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery
Hong, Zhenning
PMID: 20870723; PMCID: PMC2988372; DOI: 10.1074/jbc.M110.149575;.
Boucher I, Rich C, Lee A, Marcincin M, Trinkaus-Randall V. The P2Y2 receptor mediates the epithelial injury response and cell migration. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C411-21. PMID: 20427708; PMCID: PMC2928627; DOI: 10.1152/ajpcell.00100.2009;.
Wang X, Belguise K, O'Neill CF, Sánchez-Morgan N, Romagnoli M, Eddy SF, Mineva ND, Yu Z, Min C, Trinkaus-Randall V, Chalbos D, Sonenshein GE. RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Mol Cell Biol. 2009 Jul; 29(14):3832-44.View Related Profiles.
Sonenshein, Gail
Trinkaus-Randall, Vickery
PMID: 19433448; PMCID: PMC2704748; DOI: 10.1128/MCB.00032-09;.
Ren R, Hutcheon AE, Guo XQ, Saeidi N, Melotti SA, Ruberti JW, Zieske JD, Trinkaus-Randall V. Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures. Dev Dyn. 2008 Oct; 237(10):2705-15.View Related Profiles.
Ren, Ruiyi
Trinkaus-Randall, Vickery
PMID: 18624285; PMCID: PMC3760227; DOI: 10.1002/dvdy.21606;.
Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4384-91.View Related Profiles.
Ren, Ruiyi
Trinkaus-Randall, Vickery
PMID: 18502993; PMCID: PMC2605938; DOI: 10.1167/iovs.08-1688;.
Ren R, Hong Z, Connors LH, Skinner M, Costello CE, Trinkaus-Randall V. GAGs associated with fibril extracts mediate fibrillogenesis in AL amyloidosis XII International Symposium on Amyloidosis. CRC press. Ed. By Skinner, Connors, Seldin and Birk. 2008; 33-35.
Guo X, Hutcheon AE, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4050-60. PMID: 17724187.
Boucher I, Yang L, Mayo C, Klepeis V, Trinkaus-Randall V. Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway. Exp Eye Res. 2007 Jul; 85(1):130-41. PMID: 17490650; PMCID: PMC2577227.
Ruberti J, Zieske JD, Trinkaus-Randall V. Corneal Tissue Replacement. In: The Principles of Tissue Engineering. Ch. 68. ed. Lanza R, Langer R, Vacanti. Elsevier. 2007.
Monis GF, Schultz C, Ren R, Eberhard J, Costello C, Connors L, Skinner M, Trinkaus-Randall V. Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts. Am J Pathol. 2006 Dec; 169(6):1939-52.View Related Profiles.
Costello, Catherine
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery
PMID: 17148659; PMCID: PMC1762491.
Monis G, Eberhard J, Connors L, Skinner M, Trinkaus-Randall V. Amyloid. Cardiac fibroblasts process amyloid fight chains: A lysosomal pathway?. 11th International Symposium on Amyloidosis. 2006; 13.
Ren R, Hong Z, Gantz D, Connors L, Skinner M, Costello C, Trinkaus-Randall V. Amyloid. Fibril formation is mediated by sulfated glycosaminoglycans. 11th International Symposium on Amyloidosis. 2006; 13.
Weinger I, Klepeis VE, Trinkaus-Randall V. Tri-nucleotide receptors play a critical role in epithelial cell wound repair. Purinergic Signal. 2005 Sep; 1(3):281-92. PMID: 18404512; PMCID: PMC2096543; DOI: 10.1007/s11302-005-8132-6;.
Kaczmarek E, Erb L, Koziak K, Jarzyna R, Wink MR, Guckelberger O, Blusztajn JK, Trinkaus-Randall V, Weisman GA, Robson SC. Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways. Thromb Haemost. 2005 Apr; 93(4):735-42.View Related Profiles.
Blusztajn, Jan
Trinkaus-Randall, Vickery
PMID: 15841322; PMCID: PMC2830093.
Trinkaus-Randall V, Walsh MT, Steeves S, Monis G, Connors LH, Skinner M. Cellular response of cardiac fibroblasts to amyloidogenic light chains. Am J Pathol. 2005 Jan; 166(1):197-208.View Related Profiles.
Connors, Lawreen
Skinner, Martha
Trinkaus-Randall, Vickery
PMID: 15632012; PMCID: PMC1602293.
Klepeis VE, Weinger I, Kaczmarek E, Trinkaus-Randall V. P2Y receptors play a critical role in epithelial cell communication and migration. J Cell Biochem. 2004 Dec 15; 93(6):1115-33. PMID: 15449317.
Yang L, Cranson D, Trinkaus-Randall V. Cellular injury induces activation of MAPK via P2Y receptors. J Cell Biochem. 2004 Apr 1; 91(5):938-50. PMID: 15034929.
Song QH, Gong H, Trinkaus-Randall V. Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit beta4. Cell Tissue Res. 2003 May; 312(2):203-20.View Related Profiles.
Gong, Haiyan
Trinkaus-Randall, Vickery
PMID: 12715147.
Shuai JW, Nadkarni S, Jung P, Cornell-Bell A, Trinkaus-Randall V. Mathematical modeling of intracellular and intercellular calcium signaling. Advances in Molecular and Cell Biology. 2003; 31:689-706. View Publication
Cornell-Bell, AH, Jung P, Trinkaus-Randall V . Decoding Calcium wave signaling. In. Adv Molecular and Cell Biology. Elsevier Science. 2003; 31:661-689.
Brown CT, Lin P, Walsh MT, Gantz D, Nugent MA, Trinkaus-Randall V. Extraction and purification of decorin from corneal stroma retain structure and biological activity. Protein Expr Purif. 2002 Aug; 25(3):389-99.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 12182818.
Song QH, Klepeis VE, Nugent MA, Trinkaus-Randall V. TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing. Mol Pathol. 2002 Jun; 55(3):164-76.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 12032227; PMCID: PMC1187169.
Griffith M, Trinkaus-Randall V, Watsky MA, Liu CY, Sheardown H. Methods of Tissue Engineering. Cornea. 2002; 927-941. View Publication
Griffith M, Watsky MA, Liu CY, Trinkaus-Randall V. Methods of Tissue Engineering. Epithelial Cell Culture. 2002; 131-140. View Publication
Klepeis VE, Cornell-Bell A, Trinkaus-Randall V. Growth factors but not gap junctions play a role in injury-induced Ca2+ waves in epithelial cells. J Cell Sci. 2001 Dec; 114(Pt 23):4185-95. PMID: 11739651.
Sanghi S, Kumar R, Lumsden A, Dickinson D, Klepeis V, Trinkaus-Randall V, Frierson HF, Laurie GW. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. J Mol Biol. 2001 Jun 29; 310(1):127-39. PMID: 11419941.
Richardson TP, Trinkaus-Randall V, Nugent MA. Regulation of heparan sulfate proteoglycan nuclear localization by fibronectin. J Cell Sci. 2001 May; 114(Pt 9):1613-23.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 11309193.
Song QH, Singh RP, Trinkaus-Randall V. Injury and EGF mediate the expression of alpha6beta4 integrin subunits in corneal epithelium. J Cell Biochem. 2001; 80(3):397-414. PMID: 11135371.
Jung P, Cornell-Bell AH, Dreher M, deGrauw A, Strawsburg R, Trinkaus-Randall V. Statistical analysis and modeling in calcium waves in healthy and pathological astrocyte syncytia. In: Neuro- Informatics and Neural Modelling. Handbook of Biological Physics, Ch. 10. 2001; 4:323-352.
Kypreos KE, Birk D, Trinkaus-Randall V, Hartmann DJ, Sonenshein GE. Type V collagen regulates the assembly of collagen fibrils in cultures of bovine vascular smooth muscle cells. J Cell Biochem. 2000 Sep 18; 80(1):146-55.View Related Profiles.
Sonenshein, Gail
Trinkaus-Randall, Vickery
PMID: 11029762.
Trinkaus-Randall V, Kewalramani R, Payne J, Cornell-Bell A. Calcium signaling induced by adhesion mediates protein tyrosine phosphorylation and is independent of pHi. J Cell Physiol. 2000 Sep; 184(3):385-99. PMID: 10911371.
Payne J, Gong H, Trinkaus-Randall V. Tyrosine phosphorylation: a critical component in the formation of hemidesmosomes. Cell Tissue Res. 2000 Jun; 300(3):401-11.View Related Profiles.
Gong, Haiyan
Trinkaus-Randall, Vickery
PMID: 10928271.
Song QH, Singh RP, Richardson TP, Nugent MA, Trinkaus-Randall V. Transforming growth factor-beta1 expression in cultured corneal fibroblasts in response to injury. J Cell Biochem. 2000 Mar; 77(2):186-99.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 10723086.
Trinkaus-Randall V. Principles of Tissue Engineering. Cornea. 2000; 471-491. View Publication
Richardson TP, Trinkaus-Randall V, Nugent MA. Fibronectin directs nuclear localization of cell surface heparan sulfate proteoglycans. The FASEB Journal. 2000; 14(8):A1349-A1349.
Trinkaus-Randall V. Cornea: Biological Responses. Ch. 35 pp 471-491 In: Principles of Tissue Engineering (second edition). eds. Lanza R, Langer R, Chick E. Academic Press, Calif. 2000.
Richardson TP, Trinkaus-Randall V, Nugent MA. Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfate. J Biol Chem. 1999 May 7; 274(19):13534-40.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 10224122.
Brown CT, Nugent MA, Lau FW, Trinkaus-Randall V. Characterization of proteoglycans synthesized by cultured corneal fibroblasts in response to transforming growth factor beta and fetal calf serum. J Biol Chem. 1999 Mar 12; 274(11):7111-9.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 10066769.
James MF, Rich CB, Trinkaus-Randall V, Rosenbloom J, Foster JA. Elastogenesis in the developing chick lung is transcriptionally regulated. Dev Dyn. 1998 Oct; 213(2):170-81. PMID: 9786417.
Haq F, Trinkaus-Randall V. Injury of stromal fibroblasts induces phosphorylation of focal adhesion proteins. Curr Eye Res. 1998 May; 17(5):512-23. PMID: 9617547.
Wu XY, Tsuk A, Leibowitz HM, Trinkaus-Randall V. In vivo comparison of three different porous materials intended for use in a keratoprosthesis. Br J Ophthalmol. 1998 May; 82(5):569-76. PMID: 9713067; PMCID: PMC1722587.
Trinkaus-Randall V, Nugent MA. Biological response to a synthetic cornea. J Control Release. 1998 Apr 30; 53(1-3):205-14.View Related Profiles.
Nugent, Matthew
Trinkaus-Randall, Vickery
PMID: 9741928.
Leibowitz HM, Trinkaus-Randall V, Tsuk A, Franzblau C. Keratoprosthesis:Progress in the Development of a synthetic Cornea. Ch.40. pp 1107-1124 In: Corneal Disorders Clinical Diagnosis and Management. Ed. H.M. Leibowitz and G.O.Waring. W.B. Saunders and Co. PA. 1998.
Svoboda KK, Gong H, Trinkaus-Randall V. Collagen expression and orientation in ocular tissues. Progress in Polymer Science. 1998; 23:329-374.
Trinkaus-Randall V, Edelhauser HF, Leibowitz HM, Freddo TF. Corneal Structure and Function. Ch. 1 pp2-32 In: Corneal Disorders Clinical Diagnosis and Management. Ed. Leibowitz HM, Waring GO. W.B. Saunders and Co. PA. 1998.
James MF, Rich CB, Trinkaus-Randall V, Foster JA. In vitro transfection by calcium phosphate. Ch. 9 pp 158-174 In: DNA transfer to cultured cells. eds. Ravid K and Freshney. Wiley Liss, Inc. New York. 1998.
Trinkaus-Randall V, Wu XY, Tablante R, Tsuk A. Implantation of a synthetic cornea: design, development and biological response. Artif Organs. 1997 Nov; 21(11):1185-91. PMID: 9384324.
Hirsch MS, Lunsford LE, Trinkaus-Randall V, Svoboda KK. Chondrocyte survival and differentiation in situ are integrin mediated. Dev Dyn. 1997 Nov; 210(3):249-63. PMID: 9389451.
Wu XY, Trinkaus-Randall V. The expression of integrin subunits alpha 6 and beta 4 by corneal epithelial cells on modified hydrogel surfaces. J Biomed Mater Res. 1997 Nov; 37(2):166-75. PMID: 9358308.
Latkany R, Tsuk A, Sheu MS, Loh IH, Trinkaus-Randall V. Plasma surface modification of artificial corneas for optimal epithelialization. J Biomed Mater Res. 1997 Jul; 36(1):29-37. PMID: 9212386.
Tsuk AG, Trinkaus-Randall V, Leibowitz HM. Advances in polyvinyl alcohol hydrogel keratoprostheses: protection against ultraviolet light and fabrication by a molding process. J Biomed Mater Res. 1997 Mar 5; 34(3):299-304. PMID: 9086399.
Grushkin-Lerner LS, Kewalramani R, Trinkaus-Randall V. Expression of integrin receptors on plasma membranes of primary corneal epithelial cells is matrix specific. Exp Eye Res. 1997 Mar; 64(3):323-34. PMID: 9196383.
Wu XY, Brown CT, Trinkaus-Randall V. The localization and expression of glycosaminoglycans and growth factors in response to stromal implants. Matrix Biology. 1997; 16(3):129. View Publication
Kewalramani R, Payne J, Trinakus-Randall V. Effect of calcium on phosphorylation in cell-matrix signal transduction events in corneal epithelium. Matrix Biology. 1997; 16(3):119. View Publication
Trinkaus-Randall V, Comeli-Bell A, Kewalramani R, Payne J. Changes in intracellular ca2+ are mediated by the adhesion of epithelial cells to matrix proteins. 1997.
Trinkaus-Randall V. Cornea. Ch. 26 pp 383-398 In: Principles of Tissue Engineering. eds. Lanza R, Langer R, Chick E. Academic Press, Calif. 1997.
Trinkaus-Randall V, Payne J, Haq F. Phosphorylation of epithelial cells and stromal fibroblasts is mediated by adhesion. 1996.
Brown CT, Applebaum E, Banwatt R, Trinkaus-Randall V. Synthesis of stromal glycosaminoglycans in response to injury. J Cell Biochem. 1995 Sep; 59(1):57-68. PMID: 8530537.
Wu XY, Svoboda KK, Trinkaus-Randall V. Distribution of F-actin, vinculin and integrin subunits (alpha 6 and beta 4) in response to corneal substrata. Exp Eye Res. 1995 Apr; 60(4):445-58. PMID: 7789424.
Brown CT, Vural M, Johnson M, Trinkaus-Randall V. Age-related changes of scleral hydration and sulfated glycosaminoglycans. Mech Ageing Dev. 1994 Dec 16; 77(2):97-107. PMID: 7745995.
Hirsch MS, Law LY, Trinkaus-Randall V, Svoboda KK. The intracellular distribution of vinculin and alpha 2 integrin in epithelial cells and chondrocytes. Scanning. 1994 Sep-Oct; 16(5):275-84. PMID: 7994488.
Wu XY, Cornell-Bell A, Davies TA, Simons ER, Trinkaus-Randall V. Expression of integrin and organization of F-actin in epithelial cells depends on the underlying surface. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):878-90.View Related Profiles.
Simons, Elizabeth
Davies-Heerema, Theresa
Trinkaus-Randall, Vickery
PMID: 8125751.
Trinkaus-Randall V, Banwatt R, Wu XY, Leibowitz HM, Franzblau C. Effect of pretreating porous webs on stromal fibroplasia in vivo. J Biomed Mater Res. 1994 Feb; 28(2):195-202.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 8207031.
Hirsch MS, Trinkaus-Randall V, Svoboda KKH. Intracellular changes may precede specific hypertrophic markers in differentiating chondrocytes. Matrix Biology. 1994; 14(5):375. View Publication
Leibowitz HM, Trinkaus-Randall V, Tsuk A, Franzblau C. Progress in the development of a synthetic cornea. Ch. 7 pp 605-621. In: Progress in Retinal and Eye Research. Vol.13 (2). Elsevier Science Ltd. Great Britain. 1994.
Trinkaus-Randall V, Tong M, Thomas P, Cornell-Bell A. Confocal imaging of the alpha 6 and beta 4 integrin subunits in the human cornea with aging. Invest Ophthalmol Vis Sci. 1993 Oct; 34(11):3103-9. PMID: 8407218.
Trinkaus-Randall V, Banwatt R, Capecchi J, Leibowitz HM, Franzblau C. In vivo fibroplasia of a porous polymer in the cornea. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3245-51.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 1748554.
Trinkaus-Randall V, Leibowitz HM, Ryan WJ, Kupferman A. Quantification of stromal destruction in the inflamed cornea. Invest Ophthalmol Vis Sci. 1991 Mar; 32(3):603-9. PMID: 2001934.
Grushkin-Lerner LS, Trinkaus-Randall V. Localization of integrin and syndecan in vivo in a corneal epithelial abrasion and keratectomy. Curr Eye Res. 1991 Jan; 10(1):75-85. PMID: 2029850.
Trinkaus-Randall V, Capecchi J, Sammon L, Gibbons D, Leibowitz HM, Franzblau C. In vitro evaluation of fibroplasia in a porous polymer. Invest Ophthalmol Vis Sci. 1990 Jul; 31(7):1321-6.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 2365562.
Trinkaus-Randall V, Newton AW, Franzblau C. The synthesis and role of integrin in corneal epithelial cells in culture. Invest Ophthalmol Vis Sci. 1990 Mar 1; 31(3):440-7.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 2108096.
Gong HY, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989 Oct; 8(10):1071-82.View Related Profiles.
Gong, Haiyan
Trinkaus-Randall, Vickery
PMID: 2612196.
Bergethon PR, Trinkaus-Randall V, Franzblau C. Modified hydroxyethylmethacrylate hydrogels as a modelling tool for the study of cell-substratum interactions. J Cell Sci. 1989 Jan; 92 ( Pt 1):111-21.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 2777911.
Gong H, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989; 8(10):1071-1081.View Related Profiles.
Gong, Haiyan
Trinkaus-Randall, Vickery
PMID: 28692813.
Trinkaus-Randall V, Newton A, Franzblau C. Influence of substratum on corneal epithelial cell growth and protein synthesis. Invest Ophthalmol Vis Sci. 1988 Dec; 29(12):1800-9.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 3192369.
Trinkaus-Randall V, Capecchi J, Newton A, Vadasz A, Leibowitz H, Franzblau C. Development of a biopolymeric keratoprosthetic material. Evaluation in vitro and in vivo. Invest Ophthalmol Vis Sci. 1988 Mar; 29(3):393-400.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 3343096.
Trinkaus-Randall V, Newton AW, Gipson IK, Franzblau C. Carbohydrate moieties of the basal lamina: their role in attachment and spreading of basal corneal epithelial cells. Cell Tissue Res. 1988 Feb; 251(2):315-23.View Related Profiles.
Franzblau, Carl
Trinkaus-Randall, Vickery
PMID: 3345547.
Gipson IK, Trinkaus-Randall V. Conditions for formation of hemidesmosomes in vitro pp.31-49 In: Processes in cutaneous epidermal differentiation. Ed Bernstein IA and Hirone T. Praeger. New York. 1987.
Trinkaus-Randall V, Gipson IK. A technique for obtaining basal corneal epithelial cells. Invest Ophthalmol Vis Sci. 1985 Feb; 26(2):233-7. PMID: 3972504.
Trinkaus-Randall V, Govind CK. Development of bilateral asymmetry in the cheliped extensor muscle of male fiddler crabs. J Crust Biol. 1985; 5:25-29.
Trinkaus-Randall V, Gipson IK. Role of calcium and calmodulin in hemidesmosome formation in vitro. J Cell Biol. 1984 Apr; 98(4):1565-71. PMID: 6715411; PMCID: PMC2113221.
Trinkaus-Randall V. Regeneration of transplanted chelae in two species of fiddler crabs (Uca pugilator and Uca pugnax). J Exp Zool. 1982; 224:13-24.
Govind CK, Stephens PJ, Trinkaus-Randall V. Differences in motor output and fiber composition of the opener muscle in lobster dimorphic claws. J Exp Zool. 1981; 218:363-370. View Publication
Trinkaus-Randall V, Mittenthal JE. Intra- and interspecific transplantation of limb bud in crustacean limbs. J Exp Zool. 1978; 204:275-281. View Publication
Pappenheimer AM, Randall V. On the alleged high sensitivity of mouse Ehrlich-Lettre ascites tumor cells to diphtheria toxin. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):3149-52. PMID: 1059101; PMCID: PMC432938.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 108 publications over 36 distinct years, with a maximum of 10 publications in 1997

Bar chart showing 108 publications over 36 distinct years, with a maximum of 10 publications in 1997

Year	Publications
1981	1
1982	1
1984	1
1985	2
1987	1
1988	3
1989	3
1990	2
1991	3
1993	1
1994	6
1995	2
1996	1
1997	10
1998	8
1999	2
2000	7
2001	5
2002	4
2003	3
2004	2
2005	3
2006	3
2007	3
2008	3
2009	1
2010	2
2011	5
2012	3
2013	3
2014	4
2015	3
2016	1
2017	1
2018	2
2019	3

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