Vickery Trinkaus-Randall, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, University of Wisconsin Madison
BA, Kenyon College



Our laboratory is interested in the wound response and repair of epithelium, neurons and extracellular matrix. 1. In the healthy cornea there are no blood vessels and thus the tissue provides an excellent model to study the communication between nerves and epithelium following injury. Primary neurons are co-cultured with epithelial cells to ask how signaling pathways communicate. These include but are not limited to glutamatergic and purinergic receptor-mediated calcium transients. 2. In addition to these signaling events we have found that when epithelial cells are injured nucleotides are released immediately and cause a distinct phosphorylation of EGF receptor residues that ultimately affect the ability of a cell to migrate. 3. To study controlling factors on extracellular matrix or stromal formation we have developed scaffold-free long-term cultures and these have recently enabled us to study the role of hypoxia, which occurs in a diurnal pattern in this tissue as one sleeps. Our experiments are conducted using a number of organ culture and cell models and use biochemical, cell and molecular techniques. 4. Last but not least we are interested in the role of long sugar chains or glycosaminoglycans on the formation of oligomers and fibrils in light chain amyloid disease using atomic force microscopy, negative staining and biochemical technologies.

Professor
Boston University Chobanian & Avedisian School of Medicine
Ophthalmology


Member
Boston University
Amyloidosis Center


Member
Boston University
Genome Science Institute


Co-Director
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
MD/PhD Program


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Delayed wound healing in diabetic corneal epithelia: reduction in protein response after injury and uncoordinated cell-cell communication
07/01/2022 - 06/30/2026 (Key Person / Mentor)
NIH/National Eye Institute
5F30EY033647-02

Molecular Mechanisms of corneal wound repair
09/01/2021 - 08/31/2024 (PI)
NIH/National Eye Institute
5R01EY032079-03

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2024 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Calcium oscillations and cell motility with corneal injury
02/01/2019 - 01/31/2022 (PI)
NIH/National Eye Institute
5R21EY029097-02

The Role of Sustained Calcium Oscillations in the Wound Healing Response
09/01/2017 - 01/31/2022 (Key Person / Mentor)
PI: Yoonjoo Lee, MD, PhD
NIH/National Eye Institute
5F30EY028001-04

Molecular Mechanisms of corneal wound repair
09/30/2018 - 09/29/2021 (PI)
NIH/National Eye Institute
2R01EY006000-31

Corneal Epithelial Adhesion: Morphology and Biochemistry
08/01/2014 - 09/29/2018 (PI)
NIH/National Eye Institute
5R01EY006000-30

Multicellular Regulation of Corneal Wound Healing
12/01/2014 - 11/30/2017 (PI)
NIH/National Eye Institute
5R21EY024392-02

Corneal Epithelial Adhesion: Morphology & Biochemistry
06/01/1986 - 05/31/2014 (PI)
NIH/National Eye Institute
5R01EY006000-26

Engineering Biomimetric Corneal Constructs
09/30/2009 - 09/29/2011 (Subcontract PI)
Northeastern University NIH NEI
5R01EY015500-06

Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 Molecular Mechanisms of corneal wound repair 5R01EY032079-03
2022 Molecular Mechanisms of corneal wound repair 5R01EY032079-02
2021 Molecular Mechanisms of corneal wound repair 1R01EY032079-01A1
2020 Calcium oscillations and cell motility with corneal injury 5R21EY029097-02
2019 Calcium oscillations and cell motility with corneal injury 1R21EY029097-01A1
2018 Molecular Mechanisms of corneal wound repair 2R01EY006000-31 41
2017 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-30 41
2016 Multicellular regulation of corneal wound healing 5R21EY024392-02 1
2016 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-29 41
2015 Multicellular regulation of corneal wound healing 1R21EY024392-01A1 1
Showing 10 of 60 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Azzari NA, Segars KL, Rapaka S, Kushimi L, Rich CB, Trinkaus-Randall V. Aberrations in Cell Signaling Quantified in Diabetic Murine Globes after Injury. Cells. 2023 Dec 21; 13(1). PMID: 38201230; PMCID: PMC10778404; DOI: 10.3390/cells13010026;
     
  2. Segars KL, Trinkaus-Randall V. Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas. Ocul Surf. 2023 Oct; 30:85-91. PMID: 37657650
     
  3. Segars KL, Azzari NA, Gomez S, Rich CB, Trinkaus-Randall V. Live-Cell Imaging of Intact Ex Vivo Globes Using a Novel 3D Printed Holder. J Vis Exp. 2022 Oct 06; (188). PMID: 36282717; PMCID: PMC10171086; DOI: 10.3791/64510;
     
  4. Segars KL, Azzari NA, Gomez S, Machen C, Rich CB, Trinkaus-Randall V. Age Dependent Changes in Corneal Epithelial Cell Signaling. Front Cell Dev Biol. 2022; 10:886721. PMID: 35602595; PMCID: PMC9117764; DOI: 10.3389/fcell.2022.886721;
     
  5. Rhodes G, Segars KL, Lee YK, Hutcheon AEK, Rich CB, Trinkaus-Randall V. Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium. Anal Cell Pathol (Amst). 2021; 2021:4793338. PMID: 34336553; PMCID: PMC8295002; DOI: 10.1155/2021/4793338;
     
  6. Lee YK, Segars KL, Trinkaus-Randall V. Multiple Imaging Modalities for Cell-Cell Communication via Calcium Mobilizations in Corneal Epithelial Cells. Methods Mol Biol. 2021; 2346:11-20. PMID: 33159251; PMCID: PMC8787922; DOI: 10.1007/7651_2020_329;
     
  7. Xu P, Londregan A, Rich C, Trinkaus-Randall V. Changes in Epithelial and Stromal Corneal Stiffness Occur with Age and Obesity. Bioengineering (Basel). 2020 Feb 07; 7(1). PMID: 32046198; PMCID: PMC7175307; DOI: 10.3390/bioengineering7010014;
     
  8. Stepp MA, Trinkaus-Randall V. In memoriam: James D. Zieske, Ph.D. (1954-2020). Exp Eye Res. 2020 Feb; 191:107934. PMID: 32063264
     
  9. Stepp MA, Trinkaus-Randall V. In memoriam: James D. Zieske, Ph.D. (1954-2020). Exp Eye Res. 2020 Feb; 191:107934. PMID: 31945322
     
  10. Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles. PMID: 31017899; PMCID: PMC6481807; DOI: 10.1371/journal.pone.0213422;
     
Showing 10 of 119 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 117 publications over 40 distinct years, with a maximum of 10 publications in 1997

YearPublications
19811
19821
19841
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19931
19946
19952
19961
199710
19988
19992
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20161
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20182
20193
20203
20212
20222
20232


2013 GMS Faculty Recognition Award
2010 Gold Fellow of ARVO (Association for Research in Vision and Ophthalmology)

During my time at BU I have come to embrace the importance of mentoring. I enjoy mentoring both students and faculty. I have worked at a National level with ARVO as a mentor and been available through departments as a mentor. I have also anonymously reviewed grants for junior investigators.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Instructional (L)
Boston MA 02118
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