Vickery Trinkaus-Randall, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Wisconsin Madison




Our laboratory is interested in the wound response and repair of epithelium, neurons and extracellular matrix. 1. In the healthy cornea there are no blood vessels and thus the tissue provides an excellent model to study the communication between nerves and epithelium following injury. Primary neurons are co-cultured with epithelial cells to ask how signaling pathways communicate. These include but are not limited to glutamatergic and purinergic receptor-mediated calcium transients. 2. In addition to these signaling events we have found that when epithelial cells are injured nucleotides are released immediately and cause a distinct phosphorylation of EGF receptor residues that ultimately affect the ability of a cell to migrate. 3. To study controlling factors on extracellular matrix or stromal formation we have developed scaffold-free long-term cultures and these have recently enabled us to study the role of hypoxia, which occurs in a diurnal pattern in this tissue as one sleeps. Our experiments are conducted using a number of organ culture and cell models and use biochemical, cell and molecular techniques. 4. Last but not least we are interested in the role of long sugar chains or glycosaminoglycans on the formation of oligomers and fibrils in light chain amyloid disease using atomic force microscopy, negative staining and biochemical technologies.

Professor
Boston University School of Medicine
Ophthalmology


Member
Boston University
Amyloidosis Center


Member
Boston University
Genome Science Institute


Co-Director
Boston University School of Medicine, Graduate Medical Sciences
MD/PhD Program


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2013 GMS Faculty Recognition Award
2010 Gold Fellow of ARVO (Association for Research in Vision and Ophthalmology)


Molecular Mechanisms of corneal wound repair
09/30/2018 - 09/29/2021 (PI)
NIH/National Eye Institute
2R01EY006000-31

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 05/31/2021 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Calcium oscillations and cell motility with corneal injury
02/01/2019 - 01/31/2021 (PI)
NIH/National Eye Institute
5R21EY029097-02

Corneal Epithelial Adhesion: Morphology and Biochemistry
08/01/2014 - 09/29/2018 (PI)
NIH/National Eye Institute
5R01EY006000-30

Multicellular Regulation of Corneal Wound Healing
12/01/2014 - 11/30/2017 (PI)
NIH/National Eye Institute
5R21EY024392-02

Corneal Epithelial Adhesion: Morphology & Biochemistry
06/01/1986 - 05/31/2014 (PI)
NIH/National Eye Institute
5R01EY006000-26

Engineering Biomimetric Corneal Constructs
09/30/2009 - 09/29/2011 (Subcontract PI)
Northeastern University NIH NEI
5R01EY015500-06

Purchase of a New Confocal Zeiss LSM 510v3.2
09/01/2005 - 08/31/2006 (PI)
NIH/National Center for Health Research Resources
1 S10 RR17967 01A2

Role of Growth Factors on Epidermal and Neuronal Injury
09/30/2000 - 08/31/2003 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R21 DK59753 02

Regulation of Extracellular Matrix in the Corneal Stroma
08/01/1996 - 07/31/2000 (Co-PI)
PI: Matthew A. Nugent, PhD
NIH/National Eye Institute
5 R01 EY11004 04



Title


Yr Title Project-Sub Proj Pubs
2020 Calcium oscillations and cell motility with corneal injury 5R21EY029097-02
2019 Calcium oscillations and cell motility with corneal injury 1R21EY029097-01A1
2018 Molecular Mechanisms of corneal wound repair 2R01EY006000-31 41
2017 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-30 41
2016 Multicellular regulation of corneal wound healing 5R21EY024392-02 1
2016 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-29 41
2015 Multicellular regulation of corneal wound healing 1R21EY024392-01A1 1
2015 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-28 41
2015 Corneal Epithelial Adhesion: Morphology and Biochemistry 3R01EY006000-28S1 41
2014 Corneal Epithelial Adhesion: Morphology and Biochemistry 2R01EY006000-27A1 41
Showing 10 of 57 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Xu P, Londregan A, Rich C, Trinkaus-Randall V. Changes in Epithelial and Stromal Corneal Stiffness Occur with Age and Obesity. Bioengineering (Basel). 2020 Feb 07; 7(1). PMID: 32046198
     
  2. Stepp MA, Trinkaus-Randall V. In memoriam: James D. Zieske, Ph.D. (1954-2020). Exp Eye Res. 2020 Feb; 191:107934. PMID: 32063264
     
  3. Stepp MA, Trinkaus-Randall V. In memoriam: James D. Zieske, Ph.D. (1954-2020). Exp Eye Res. 2020 Feb; 191:107934. PMID: 31945322
     
  4. Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles. PMID: 31017899
     
  5. Onochie OE, Onyejose AJ, Rich CB, Trinkaus-Randall V. The Role of Hypoxia in Corneal Extracellular Matrix Deposition and Cell Motility. Anat Rec (Hoboken). 2020 06; 303(6):1703-1716.View Related Profiles. PMID: 30861330
     
  6. Onochie OE, Zollinger A, Rich CB, Smith M, Trinkaus-Randall V. Epithelial cells exert differential traction stress in response to substrate stiffness. Exp Eye Res. 2019 04; 181:25-37.View Related Profiles. PMID: 30653966
     
  7. Kneer K, Green MB, Meyer J, Rich CB, Minns MS, Trinkaus-Randall V. High fat diet induces pre-type 2 diabetes with regional changes in corneal sensory nerves and altered P2X7 expression and localization. Exp Eye Res. 2018 10; 175:44-55.View Related Profiles. PMID: 29883639; DOI: 10.1016/j.exer.2018.06.001;
     
  8. Lee A, Karamichos D, Onochie OE, Hutcheon AEK, Rich CB, Zieske JD, Trinkaus-Randall V. Hypoxia modulates the development of a corneal stromal matrix model. Exp Eye Res. 2018 05; 170:127-137.View Related Profiles. PMID: 29496505
     
  9. Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 Sep; 31(9):4117-4128.View Related Profiles. PMID: 28566470
     
  10. Minns MS, Trinkaus-Randall V. Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors. J Ocul Pharmacol Ther. 2016 Oct; 32(8):498-503.View Related Profiles. PMID: 27643999
     
Showing 10 of 113 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 111 publications over 37 distinct years, with a maximum of 10 publications in 1997

YearPublications
19811
19821
19841
19852
19871
19883
19893
19902
19913
19931
19946
19952
19961
199710
19988
19992
20007
20015
20024
20033
20042
20053
20063
20073
20083
20091
20102
20115
20123
20133
20144
20153
20161
20171
20182
20193
20203

Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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