Vickery Trinkaus-Randall

Vickery Trinkaus-Randall, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of Wisconsin Madison
BA, Kenyon College

Websites

	Biochemistry Faculty
	Ophthalmology Faculty
	ResearchGate
	LinkedIn

ORCID : 0000-0002-8573-9108

Our laboratory is interested in the wound response and repair of epithelium, neurons and extracellular matrix. 1. In the healthy cornea there are no blood vessels and thus the tissue provides an excellent model to study the communication between nerves and epithelium following injury. Primary neurons are co-cultured with epithelial cells to ask how signaling pathways communicate. These include but are not limited to glutamatergic and purinergic receptor-mediated calcium transients. 2. In addition to these signaling events we have found that when epithelial cells are injured nucleotides are released immediately and cause a distinct phosphorylation of EGF receptor residues that ultimately affect the ability of a cell to migrate. 3. To study controlling factors on extracellular matrix or stromal formation we have developed scaffold-free long-term cultures and these have recently enabled us to study the role of hypoxia, which occurs in a diurnal pattern in this tissue as one sleeps. Our experiments are conducted using a number of organ culture and cell models and use biochemical, cell and molecular techniques. 4. Last but not least we are interested in the role of long sugar chains or glycosaminoglycans on the formation of oligomers and fibrils in light chain amyloid disease using atomic force microscopy, negative staining and biochemical technologies.

Professor
Boston University Chobanian & Avedisian School of Medicine
Ophthalmology

Member
Boston University
Amyloidosis Center

Member
Boston University
Genome Science Institute

Co-Director
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
MD/PhD Program

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Delayed wound healing in diabetic corneal epithelia: reduction in protein response after injury and uncoordinated cell-cell communication
07/01/2022 - 06/30/2026 (Key Person / Mentor)
NIH/National Eye Institute
5F30EY033647-02

Molecular Mechanisms of corneal wound repair
09/01/2021 - 08/31/2024 (PI)
NIH/National Eye Institute
5R01EY032079-03

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2023 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Calcium oscillations and cell motility with corneal injury
02/01/2019 - 01/31/2022 (PI)
NIH/National Eye Institute
5R21EY029097-02

The Role of Sustained Calcium Oscillations in the Wound Healing Response
09/01/2017 - 01/31/2022 (Key Person / Mentor)
PI: Yoonjoo Lee, MD, PhD
NIH/National Eye Institute
5F30EY028001-04

Molecular Mechanisms of corneal wound repair
09/30/2018 - 09/29/2021 (PI)
NIH/National Eye Institute
2R01EY006000-31

Corneal Epithelial Adhesion: Morphology and Biochemistry
08/01/2014 - 09/29/2018 (PI)
NIH/National Eye Institute
5R01EY006000-30

Multicellular Regulation of Corneal Wound Healing
12/01/2014 - 11/30/2017 (PI)
NIH/National Eye Institute
5R21EY024392-02

Corneal Epithelial Adhesion: Morphology & Biochemistry
06/01/1986 - 05/31/2014 (PI)
NIH/National Eye Institute
5R01EY006000-26

Engineering Biomimetric Corneal Constructs
09/30/2009 - 09/29/2011 (Subcontract PI)
Northeastern University NIH NEI
5R01EY015500-06

Showing 10 of 13 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Molecular Mechanisms of corneal wound repair	5R01EY032079-03
2022	Molecular Mechanisms of corneal wound repair	5R01EY032079-02
2021	Molecular Mechanisms of corneal wound repair	1R01EY032079-01A1
2020	Calcium oscillations and cell motility with corneal injury	5R21EY029097-02
2019	Calcium oscillations and cell motility with corneal injury	1R21EY029097-01A1
2018	Molecular Mechanisms of corneal wound repair	2R01EY006000-31	41
2017	Corneal Epithelial Adhesion: Morphology and Biochemistry	5R01EY006000-30	41
2016	Multicellular regulation of corneal wound healing	5R21EY024392-02	1
2016	Corneal Epithelial Adhesion: Morphology and Biochemistry	5R01EY006000-29	41
2015	Multicellular regulation of corneal wound healing	1R21EY024392-01A1	1

Showing 10 of 60 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Segars KL, Azzari NA, Gomez S, Rich CB, Trinkaus-Randall V. Live-Cell Imaging of Intact Ex Vivo Globes Using a Novel 3D Printed Holder. J Vis Exp. 2022 Oct 06; (188). PMID: 36282717; PMCID: PMC10171086; DOI: 10.3791/64510;

Segars KL, Azzari NA, Gomez S, Machen C, Rich CB, Trinkaus-Randall V. Age Dependent Changes in Corneal Epithelial Cell Signaling. Front Cell Dev Biol. 2022; 10:886721. PMID: 35602595; PMCID: PMC9117764; DOI: 10.3389/fcell.2022.886721;

Rhodes G, Segars KL, Lee YK, Hutcheon AEK, Rich CB, Trinkaus-Randall V. Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium. Anal Cell Pathol (Amst). 2021; 2021:4793338. PMID: 34336553; PMCID: PMC8295002; DOI: 10.1155/2021/4793338;

Lee YK, Segars KL, Trinkaus-Randall V. Multiple Imaging Modalities for Cell-Cell Communication via Calcium Mobilizations in Corneal Epithelial Cells. Methods Mol Biol. 2021; 2346:11-20. PMID: 33159251; PMCID: PMC8787922; DOI: 10.1007/7651_2020_329;

Xu P, Londregan A, Rich C, Trinkaus-Randall V. Changes in Epithelial and Stromal Corneal Stiffness Occur with Age and Obesity. Bioengineering (Basel). 2020 Feb 07; 7(1). PMID: 32046198; PMCID: PMC7175307; DOI: 10.3390/bioengineering7010014;

Stepp MA, Trinkaus-Randall V. In memoriam: James D. Zieske, Ph.D. (1954-2020). Exp Eye Res. 2020 Feb; 191:107934. PMID: 31945322

Stepp MA, Trinkaus-Randall V. In memoriam: James D. Zieske, Ph.D. (1954-2020). Exp Eye Res. 2020 Feb; 191:107934. PMID: 32063264

Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles.

Gabel, Christopher
Trinkaus-Randall, Vickery
Kolachalama, Vijaya

PMID: 31017899; PMCID: PMC6481807; DOI: 10.1371/journal.pone.0213422;

Onochie OE, Onyejose AJ, Rich CB, Trinkaus-Randall V. The Role of Hypoxia in Corneal Extracellular Matrix Deposition and Cell Motility. Anat Rec (Hoboken). 2020 06; 303(6):1703-1716.View Related Profiles.

Onochie, Obi
Trinkaus-Randall, Vickery

PMID: 30861330; PMCID: PMC8827063; DOI: 10.1002/ar.24110;

Onochie OE, Zollinger A, Rich CB, Smith M, Trinkaus-Randall V. Epithelial cells exert differential traction stress in response to substrate stiffness. Exp Eye Res. 2019 04; 181:25-37.View Related Profiles.

Onochie, Obi
Trinkaus-Randall, Vickery

PMID: 30653966; PMCID: PMC6443458; DOI: 10.1016/j.exer.2019.01.014;

Showing 10 of 117 results. Show More

Kneer K, Green MB, Meyer J, Rich CB, Minns MS, Trinkaus-Randall V. High fat diet induces pre-type 2 diabetes with regional changes in corneal sensory nerves and altered P2X7 expression and localization. Exp Eye Res. 2018 10; 175:44-55.View Related Profiles.

Minns, Martin
Trinkaus-Randall, Vickery

PMID: 29883639; PMCID: PMC6217827; DOI: 10.1016/j.exer.2018.06.001;

Lee A, Karamichos D, Onochie OE, Hutcheon AEK, Rich CB, Zieske JD, Trinkaus-Randall V. Hypoxia modulates the development of a corneal stromal matrix model. Exp Eye Res. 2018 05; 170:127-137.View Related Profiles.

Onochie, Obi
Trinkaus-Randall, Vickery

PMID: 29496505; PMCID: PMC5924608; DOI: 10.1016/j.exer.2018.02.021;

Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 Sep; 31(9):4117-4128.View Related Profiles.

Barrios, Juliana
Patel, Kruti
Minns, Martin
Trinkaus-Randall, Vickery
Ai, Xingbin
Lee, Yoonjoo

PMID: 28566470; PMCID: PMC5572694; DOI: 10.1096/fj.201700115R;

Minns MS, Trinkaus-Randall V. Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors. J Ocul Pharmacol Ther. 2016 Oct; 32(8):498-503.View Related Profiles.

Minns, Martin
Trinkaus-Randall, Vickery

PMID: 27643999; PMCID: PMC5069712; DOI: 10.1089/jop.2016.0009;

Minns MS, Teicher G, Rich CB, Trinkaus-Randall V. Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury. Am J Pathol. 2016 Feb; 186(2):285-96.View Related Profiles.

Minns, Martin
Trinkaus-Randall, Vickery

PMID: 26683661; PMCID: PMC4729273; DOI: 10.1016/j.ajpath.2015.10.006;

Derricks KE, Trinkaus-Randall V, Nugent MA. Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb). 2015 Sep; 7(9):1011-25.View Related Profiles.

Derricks, Kelsey
Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 26183123; PMCID: PMC4558347; DOI: 10.1039/c5ib00140d;

Minns M, Teicher G, Rich CB, Trinkaus-Randall V. Experimental Biology Meeting. Inhibition of P2X7 Alters Wound-Induced Ca2+ Mobilization and Cytoskeletal Rearrangements. The FASEB Journal. 2015; 29.

Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Exp Eye Res. 2014 Oct; 127:270-9. PMID: 25151301; PMCID: PMC4175147; DOI: 10.1016/j.exer.2014.08.009;

Karamichos D, Hutcheon AE, Rich CB, Trinkaus-Randall V, Asara JM, Zieske JD. In vitro model suggests oxidative stress involved in keratoconus disease. Sci Rep. 2014; 4:4608. PMID: 24714342; PMCID: PMC3980225; DOI: 10.1038/srep04608;

Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, Trinkaus-Randall V. Hypoxia-induced changes in Ca(2+) mobilization and protein phosphorylation implicated in impaired wound healing. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C972-85.View Related Profiles.

Derricks, Kelsey
Minns, Martin
Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 24671101; PMCID: PMC4024710; DOI: 10.1152/ajpcell.00110.2013;

Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Exp Eye Res. 2014 Apr; 121:178-93. PMID: 24607489; PMCID: PMC4072315; DOI: 10.1016/j.exer.2014.02.007;

Karamichos D, Rich CB, Zareian R, Hutcheon AE, Ruberti JW, Trinkaus-Randall V, Zieske JD. TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophthalmol Vis Sci. 2013 Oct; 54(10):6612-9. PMID: 24022012; PMCID: PMC3803138; DOI: 10.1167/iovs.13-12861;

Kehasse A, Rich CB, Lee A, McComb ME, Costello CE, Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am J Pathol. 2013 Dec; 183(6):1841-52.View Related Profiles.

Kehasse, Amanuel
Costello, Catherine
McComb, Mark
Trinkaus-Randall, Vickery

PMID: 24095926; PMCID: PMC5745543; DOI: 10.1016/j.ajpath.2013.08.015;

Chi C, Trinkaus-Randall V. New insights in wound response and repair of epithelium. J Cell Physiol. 2013 May; 228(5):925-9. PMID: 23129239; DOI: 10.1002/jcp.24268;

Oswald DJ, Lee A, Trinidad M, Chi C, Ren R, Rich CB, Trinkaus-Randall V. Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors. PLoS One. 2012; 7(9):e44574.View Related Profiles.

Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 22970252; PMCID: PMC3436752; DOI: 10.1371/journal.pone.0044574;

Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnol Bioeng. 2012 Oct; 109(10):2683-98. PMID: 22528405; PMCID: PMC3757098; DOI: 10.1002/bit.24533;

Mankus C, Chi C, Rich C, Ren R, Trinkaus-Randall V. The P2X(7) receptor regulates proteoglycan expression in the corneal stroma. Mol Vis. 2012; 18:128-38. PMID: 22275804; PMCID: PMC3265178

Mankus C, Rich C, Minns M, Trinkaus-Randall V. Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. PLoS One. 2011; 6(12):e28541.View Related Profiles.

Minns, Martin
Trinkaus-Randall, Vickery

PMID: 22163032; PMCID: PMC3232242; DOI: 10.1371/journal.pone.0028541;

Ward JE, Ren R, Toraldo G, Soohoo P, Guan J, O'Hara C, Jasuja R, Trinkaus-Randall V, Liao R, Connors LH, Seldin DC. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011 Dec 15; 118(25):6610-7.View Related Profiles.

O'Hara, Carl
Seldin, David
Toraldo, Gianluca
Ward, Jennifer
Connors, Lawreen
Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 21998211; PMCID: PMC3242721; DOI: 10.1182/blood-2011-04-351643;

Karamichos D, Rich CB, Hutcheon AE, Ren R, Saitta B, Trinkaus-Randall V, Zieske JD. Self-assembled matrix by umbilical cord stem cells. J Funct Biomater. 2011; 2(3):213-29.View Related Profiles.

Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 24956304; PMCID: PMC4030936; DOI: 10.3390/jfb2030213;

Boucher I, Kehasse A, Marcincin M, Rich C, Rahimi N, Trinkaus-Randall V. Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am J Pathol. 2011 Mar; 178(3):1092-105.View Related Profiles.

Kehasse, Amanuel
Rahimi, Nader
Trinkaus-Randall, Vickery

PMID: 21356361; PMCID: PMC3069885; DOI: 10.1016/j.ajpath.2010.11.060;

Karamichos D, Rich C, Hutcheon A, Ren R, Saitta B, Trinkaus-Randall V, Zieske J. Self-Assembled Matrix by Umbilical Cord Stem Cells. J. Functional Biomaterials (special issue – Biomaterials in Wound Healing). 2011.

Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82.View Related Profiles.

Costello, Catherine
Seldin, David
Gong, Haiyan
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery
Hong, Zhenning

PMID: 20870723; PMCID: PMC2988372; DOI: 10.1074/jbc.M110.149575;

Boucher I, Rich C, Lee A, Marcincin M, Trinkaus-Randall V. The P2Y2 receptor mediates the epithelial injury response and cell migration. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C411-21. PMID: 20427708; PMCID: PMC2928627; DOI: 10.1152/ajpcell.00100.2009;

Wang X, Belguise K, O'Neill CF, Sánchez-Morgan N, Romagnoli M, Eddy SF, Mineva ND, Yu Z, Min C, Trinkaus-Randall V, Chalbos D, Sonenshein GE. RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Mol Cell Biol. 2009 Jul; 29(14):3832-44.View Related Profiles.

Sonenshein, Gail
Trinkaus-Randall, Vickery

PMID: 19433448; PMCID: PMC2704748; DOI: 10.1128/MCB.00032-09;

Ren R, Hutcheon AE, Guo XQ, Saeidi N, Melotti SA, Ruberti JW, Zieske JD, Trinkaus-Randall V. Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures. Dev Dyn. 2008 Oct; 237(10):2705-15.View Related Profiles.

Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 18624285; PMCID: PMC3760227; DOI: 10.1002/dvdy.21606;

Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4384-91.View Related Profiles.

Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 18502993; PMCID: PMC2605938; DOI: 10.1167/iovs.08-1688;

Ren R, Hong Z, Connors LH, Skinner M, Costello CE, Trinkaus-Randall V. GAGs associated with fibril extracts mediate fibrillogenesis in AL amyloidosis XII International Symposium on Amyloidosis. CRC press. Ed. By Skinner, Connors, Seldin and Birk. 2008; 33-35.

Guo X, Hutcheon AE, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4050-60. PMID: 17724187; PMCID: PMC4961093; DOI: 10.1167/iovs.06-1216;

Boucher I, Yang L, Mayo C, Klepeis V, Trinkaus-Randall V. Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway. Exp Eye Res. 2007 Jul; 85(1):130-41. PMID: 17490650; PMCID: PMC2577227; DOI: 10.1016/j.exer.2007.03.009;

Ruberti J, Zieske JD, Trinkaus-Randall V. Corneal Tissue Replacement. In: The Principles of Tissue Engineering. Ch. 68. ed. Lanza R, Langer R, Vacanti. Elsevier. 2007.

Monis GF, Schultz C, Ren R, Eberhard J, Costello C, Connors L, Skinner M, Trinkaus-Randall V. Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts. Am J Pathol. 2006 Dec; 169(6):1939-52.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 17148659; PMCID: PMC1762491; DOI: 10.2353/ajpath.2006.060183;

Ren R, Hong Z, Gantz D, Connors L, Skinner M, Costello C, Trinkaus-Randall V. Amyloid. Fibril formation is mediated by sulfated glycosaminoglycans. 11th International Symposium on Amyloidosis. 2006; 13.
Monis G, Eberhard J, Connors L, Skinner M, Trinkaus-Randall V. Amyloid. Cardiac fibroblasts process amyloid fight chains: A lysosomal pathway?. 11th International Symposium on Amyloidosis. 2006; 13.

Weinger I, Klepeis VE, Trinkaus-Randall V. Tri-nucleotide receptors play a critical role in epithelial cell wound repair. Purinergic Signal. 2005 Sep; 1(3):281-92. PMID: 18404512; PMCID: PMC2096543; DOI: 10.1007/s11302-005-8132-6;

Kaczmarek E, Erb L, Koziak K, Jarzyna R, Wink MR, Guckelberger O, Blusztajn JK, Trinkaus-Randall V, Weisman GA, Robson SC. Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways. Thromb Haemost. 2005 Apr; 93(4):735-42.View Related Profiles.

Blusztajn, Jan
Trinkaus-Randall, Vickery

PMID: 15841322; PMCID: PMC2830093; DOI: 10.1267/THRO05040735;

Trinkaus-Randall V, Walsh MT, Steeves S, Monis G, Connors LH, Skinner M. Cellular response of cardiac fibroblasts to amyloidogenic light chains. Am J Pathol. 2005 Jan; 166(1):197-208.View Related Profiles.

Connors, Lawreen
Skinner, Martha
Trinkaus-Randall, Vickery

PMID: 15632012; PMCID: PMC1602293; DOI: 10.1016/S0002-9440(10)62244-4;

Klepeis VE, Weinger I, Kaczmarek E, Trinkaus-Randall V. P2Y receptors play a critical role in epithelial cell communication and migration. J Cell Biochem. 2004 Dec 15; 93(6):1115-33. PMID: 15449317

Yang L, Cranson D, Trinkaus-Randall V. Cellular injury induces activation of MAPK via P2Y receptors. J Cell Biochem. 2004 Apr 1; 91(5):938-50. PMID: 15034929

Song QH, Gong H, Trinkaus-Randall V. Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit beta4. Cell Tissue Res. 2003 May; 312(2):203-20.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 12715147

Shuai JW, Nadkarni S, Jung P, Cornell-Bell A, Trinkaus-Randall V. Mathematical modeling of intracellular and intercellular calcium signaling. Advances in Molecular and Cell Biology. 2003; 31:689-706. View Publication
Cornell-Bell, AH, Jung P, Trinkaus-Randall V . Decoding Calcium wave signaling. In. Adv Molecular and Cell Biology. Elsevier Science. 2003; 31:661-689.

Brown CT, Lin P, Walsh MT, Gantz D, Nugent MA, Trinkaus-Randall V. Extraction and purification of decorin from corneal stroma retain structure and biological activity. Protein Expr Purif. 2002 Aug; 25(3):389-99.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 12182818

Song QH, Klepeis VE, Nugent MA, Trinkaus-Randall V. TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing. Mol Pathol. 2002 Jun; 55(3):164-76.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 12032227; PMCID: PMC1187169

Griffith M, Trinkaus-Randall V, Watsky MA, Liu CY, Sheardown H. Methods of Tissue Engineering. Cornea. 2002; 927-941. View Publication
Griffith M, Watsky MA, Liu CY, Trinkaus-Randall V. Methods of Tissue Engineering. Epithelial Cell Culture. 2002; 131-140. View Publication

Klepeis VE, Cornell-Bell A, Trinkaus-Randall V. Growth factors but not gap junctions play a role in injury-induced Ca2+ waves in epithelial cells. J Cell Sci. 2001 Dec; 114(Pt 23):4185-95. PMID: 11739651

Sanghi S, Kumar R, Lumsden A, Dickinson D, Klepeis V, Trinkaus-Randall V, Frierson HF, Laurie GW. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. J Mol Biol. 2001 Jun 29; 310(1):127-39. PMID: 11419941

Richardson TP, Trinkaus-Randall V, Nugent MA. Regulation of heparan sulfate proteoglycan nuclear localization by fibronectin. J Cell Sci. 2001 May; 114(Pt 9):1613-23.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 11309193

Song QH, Singh RP, Trinkaus-Randall V. Injury and EGF mediate the expression of alpha6beta4 integrin subunits in corneal epithelium. J Cell Biochem. 2001; 80(3):397-414. PMID: 11135371

Jung P, Cornell-Bell AH, Dreher M, deGrauw A, Strawsburg R, Trinkaus-Randall V. Statistical analysis and modeling in calcium waves in healthy and pathological astrocyte syncytia. In: Neuro- Informatics and Neural Modelling. Handbook of Biological Physics, Ch. 10. 2001; 4:323-352.

Kypreos KE, Birk D, Trinkaus-Randall V, Hartmann DJ, Sonenshein GE. Type V collagen regulates the assembly of collagen fibrils in cultures of bovine vascular smooth muscle cells. J Cell Biochem. 2000 Sep 18; 80(1):146-55.View Related Profiles.

Sonenshein, Gail
Trinkaus-Randall, Vickery

PMID: 11029762

Trinkaus-Randall V, Kewalramani R, Payne J, Cornell-Bell A. Calcium signaling induced by adhesion mediates protein tyrosine phosphorylation and is independent of pHi. J Cell Physiol. 2000 Sep; 184(3):385-99. PMID: 10911371

Payne J, Gong H, Trinkaus-Randall V. Tyrosine phosphorylation: a critical component in the formation of hemidesmosomes. Cell Tissue Res. 2000 Jun; 300(3):401-11.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 10928271

Song QH, Singh RP, Richardson TP, Nugent MA, Trinkaus-Randall V. Transforming growth factor-beta1 expression in cultured corneal fibroblasts in response to injury. J Cell Biochem. 2000 Mar; 77(2):186-99.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 10723086

Richardson TP, Trinkaus-Randall V, Nugent MA. Fibronectin directs nuclear localization of cell surface heparan sulfate proteoglycans. The FASEB Journal. 2000; 14(8):A1349-A1349.
Trinkaus-Randall V. Cornea: Biological Responses. Ch. 35 pp 471-491 In: Principles of Tissue Engineering (second edition). eds. Lanza R, Langer R, Chick E. Academic Press, Calif. 2000.
Trinkaus-Randall V. Principles of Tissue Engineering. Cornea. 2000; 471-491. View Publication

Richardson TP, Trinkaus-Randall V, Nugent MA. Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfate. J Biol Chem. 1999 May 7; 274(19):13534-40.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 10224122

Brown CT, Nugent MA, Lau FW, Trinkaus-Randall V. Characterization of proteoglycans synthesized by cultured corneal fibroblasts in response to transforming growth factor beta and fetal calf serum. J Biol Chem. 1999 Mar 12; 274(11):7111-9.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 10066769

James MF, Rich CB, Trinkaus-Randall V, Rosenbloom J, Foster JA. Elastogenesis in the developing chick lung is transcriptionally regulated. Dev Dyn. 1998 Oct; 213(2):170-81. PMID: 9786417

Wu XY, Tsuk A, Leibowitz HM, Trinkaus-Randall V. In vivo comparison of three different porous materials intended for use in a keratoprosthesis. Br J Ophthalmol. 1998 May; 82(5):569-76. PMID: 9713067; PMCID: PMC1722587

Haq F, Trinkaus-Randall V. Injury of stromal fibroblasts induces phosphorylation of focal adhesion proteins. Curr Eye Res. 1998 May; 17(5):512-23. PMID: 9617547

Trinkaus-Randall V, Nugent MA. Biological response to a synthetic cornea. J Control Release. 1998 Apr 30; 53(1-3):205-14.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 9741928

James MF, Rich CB, Trinkaus-Randall V, Foster JA. In vitro transfection by calcium phosphate. Ch. 9 pp 158-174 In: DNA transfer to cultured cells. eds. Ravid K and Freshney. Wiley Liss, Inc. New York. 1998.
Leibowitz HM, Trinkaus-Randall V, Tsuk A, Franzblau C. Keratoprosthesis:Progress in the Development of a synthetic Cornea. Ch.40. pp 1107-1124 In: Corneal Disorders Clinical Diagnosis and Management. Ed. H.M. Leibowitz and G.O.Waring. W.B. Saunders and Co. PA. 1998.
Svoboda KK, Gong H, Trinkaus-Randall V. Collagen expression and orientation in ocular tissues. Progress in Polymer Science. 1998; 23:329-374.
Trinkaus-Randall V, Edelhauser HF, Leibowitz HM, Freddo TF. Corneal Structure and Function. Ch. 1 pp2-32 In: Corneal Disorders Clinical Diagnosis and Management. Ed. Leibowitz HM, Waring GO. W.B. Saunders and Co. PA. 1998.

Wu XY, Trinkaus-Randall V. The expression of integrin subunits alpha 6 and beta 4 by corneal epithelial cells on modified hydrogel surfaces. J Biomed Mater Res. 1997 Nov; 37(2):166-75. PMID: 9358308

Hirsch MS, Lunsford LE, Trinkaus-Randall V, Svoboda KK. Chondrocyte survival and differentiation in situ are integrin mediated. Dev Dyn. 1997 Nov; 210(3):249-63. PMID: 9389451

Trinkaus-Randall V, Wu XY, Tablante R, Tsuk A. Implantation of a synthetic cornea: design, development and biological response. Artif Organs. 1997 Nov; 21(11):1185-91. PMID: 9384324

Latkany R, Tsuk A, Sheu MS, Loh IH, Trinkaus-Randall V. Plasma surface modification of artificial corneas for optimal epithelialization. J Biomed Mater Res. 1997 Jul; 36(1):29-37. PMID: 9212386

Tsuk AG, Trinkaus-Randall V, Leibowitz HM. Advances in polyvinyl alcohol hydrogel keratoprostheses: protection against ultraviolet light and fabrication by a molding process. J Biomed Mater Res. 1997 Mar 5; 34(3):299-304. PMID: 9086399

Grushkin-Lerner LS, Kewalramani R, Trinkaus-Randall V. Expression of integrin receptors on plasma membranes of primary corneal epithelial cells is matrix specific. Exp Eye Res. 1997 Mar; 64(3):323-34. PMID: 9196383

Trinkaus-Randall V, Comeli-Bell A, Kewalramani R, Payne J. Changes in intracellular ca2+ are mediated by the adhesion of epithelial cells to matrix proteins. 1997.
Wu XY, Brown CT, Trinkaus-Randall V. The localization and expression of glycosaminoglycans and growth factors in response to stromal implants. Matrix Biology. 1997; 16(3):129. View Publication
Trinkaus-Randall V. Cornea. Ch. 26 pp 383-398 In: Principles of Tissue Engineering. eds. Lanza R, Langer R, Chick E. Academic Press, Calif. 1997.
Kewalramani R, Payne J, Trinakus-Randall V. Effect of calcium on phosphorylation in cell-matrix signal transduction events in corneal epithelium. Matrix Biology. 1997; 16(3):119. View Publication
Trinkaus-Randall V, Payne J, Haq F. Phosphorylation of epithelial cells and stromal fibroblasts is mediated by adhesion. 1996.

Brown CT, Applebaum E, Banwatt R, Trinkaus-Randall V. Synthesis of stromal glycosaminoglycans in response to injury. J Cell Biochem. 1995 Sep; 59(1):57-68. PMID: 8530537

Wu XY, Svoboda KK, Trinkaus-Randall V. Distribution of F-actin, vinculin and integrin subunits (alpha 6 and beta 4) in response to corneal substrata. Exp Eye Res. 1995 Apr; 60(4):445-58. PMID: 7789424

Brown CT, Vural M, Johnson M, Trinkaus-Randall V. Age-related changes of scleral hydration and sulfated glycosaminoglycans. Mech Ageing Dev. 1994 Dec 16; 77(2):97-107. PMID: 7745995

Hirsch MS, Law LY, Trinkaus-Randall V, Svoboda KK. The intracellular distribution of vinculin and alpha 2 integrin in epithelial cells and chondrocytes. Scanning. 1994 Sep-Oct; 16(5):275-84. PMID: 7994488

Wu XY, Cornell-Bell A, Davies TA, Simons ER, Trinkaus-Randall V. Expression of integrin and organization of F-actin in epithelial cells depends on the underlying surface. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):878-90.View Related Profiles.

Simons, Elizabeth
Davies-Heerema, Theresa
Trinkaus-Randall, Vickery

PMID: 8125751

Trinkaus-Randall V, Banwatt R, Wu XY, Leibowitz HM, Franzblau C. Effect of pretreating porous webs on stromal fibroplasia in vivo. J Biomed Mater Res. 1994 Feb; 28(2):195-202.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 8207031

Leibowitz HM, Trinkaus-Randall V, Tsuk A, Franzblau C. Progress in the development of a synthetic cornea. Ch. 7 pp 605-621. In: Progress in Retinal and Eye Research. Vol.13 (2). Elsevier Science Ltd. Great Britain. 1994.
Hirsch MS, Trinkaus-Randall V, Svoboda KKH. Intracellular changes may precede specific hypertrophic markers in differentiating chondrocytes. Matrix Biology. 1994; 14(5):375. View Publication

Trinkaus-Randall V, Tong M, Thomas P, Cornell-Bell A. Confocal imaging of the alpha 6 and beta 4 integrin subunits in the human cornea with aging. Invest Ophthalmol Vis Sci. 1993 Oct; 34(11):3103-9. PMID: 8407218

Trinkaus-Randall V, Banwatt R, Capecchi J, Leibowitz HM, Franzblau C. In vivo fibroplasia of a porous polymer in the cornea. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3245-51.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 1748554

Trinkaus-Randall V, Leibowitz HM, Ryan WJ, Kupferman A. Quantification of stromal destruction in the inflamed cornea. Invest Ophthalmol Vis Sci. 1991 Mar; 32(3):603-9. PMID: 2001934

Grushkin-Lerner LS, Trinkaus-Randall V. Localization of integrin and syndecan in vivo in a corneal epithelial abrasion and keratectomy. Curr Eye Res. 1991 Jan; 10(1):75-85. PMID: 2029850

Trinkaus-Randall V, Capecchi J, Sammon L, Gibbons D, Leibowitz HM, Franzblau C. In vitro evaluation of fibroplasia in a porous polymer. Invest Ophthalmol Vis Sci. 1990 Jul; 31(7):1321-6.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 2365562

Trinkaus-Randall V, Newton AW, Franzblau C. The synthesis and role of integrin in corneal epithelial cells in culture. Invest Ophthalmol Vis Sci. 1990 Mar 1; 31(3):440-7.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 2108096

Gong HY, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989 Oct; 8(10):1071-82.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 2612196

Bergethon PR, Trinkaus-Randall V, Franzblau C. Modified hydroxyethylmethacrylate hydrogels as a modelling tool for the study of cell-substratum interactions. J Cell Sci. 1989 Jan; 92 ( Pt 1):111-21.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 2777911

Gong H, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989; 8(10):1071-1081. PMID: 28692813

Trinkaus-Randall V, Newton A, Franzblau C. Influence of substratum on corneal epithelial cell growth and protein synthesis. Invest Ophthalmol Vis Sci. 1988 Dec; 29(12):1800-9.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 3192369

Trinkaus-Randall V, Capecchi J, Newton A, Vadasz A, Leibowitz H, Franzblau C. Development of a biopolymeric keratoprosthetic material. Evaluation in vitro and in vivo. Invest Ophthalmol Vis Sci. 1988 Mar; 29(3):393-400.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 3343096

Trinkaus-Randall V, Newton AW, Gipson IK, Franzblau C. Carbohydrate moieties of the basal lamina: their role in attachment and spreading of basal corneal epithelial cells. Cell Tissue Res. 1988 Feb; 251(2):315-23.View Related Profiles.

Franzblau, Carl
Trinkaus-Randall, Vickery

PMID: 3345547

Gipson IK, Trinkaus-Randall V. Conditions for formation of hemidesmosomes in vitro pp.31-49 In: Processes in cutaneous epidermal differentiation. Ed Bernstein IA and Hirone T. Praeger. New York. 1987.

Trinkaus-Randall V, Gipson IK. A technique for obtaining basal corneal epithelial cells. Invest Ophthalmol Vis Sci. 1985 Feb; 26(2):233-7. PMID: 3972504

Trinkaus-Randall V, Govind CK. Development of bilateral asymmetry in the cheliped extensor muscle of male fiddler crabs. J Crust Biol. 1985; 5:25-29.

Trinkaus-Randall V, Gipson IK. Role of calcium and calmodulin in hemidesmosome formation in vitro. J Cell Biol. 1984 Apr; 98(4):1565-71. PMID: 6715411; PMCID: PMC2113221

Trinkaus-Randall V. Regeneration of transplanted chelae in two species of fiddler crabs (Uca pugilator and Uca pugnax). J Exp Zool. 1982; 224:13-24.
Govind CK, Stephens PJ, Trinkaus-Randall V. Differences in motor output and fiber composition of the opener muscle in lobster dimorphic claws. J Exp Zool. 1981; 218:363-370. View Publication
Trinkaus-Randall V, Mittenthal JE. Intra- and interspecific transplantation of limb bud in crustacean limbs. J Exp Zool. 1978; 204:275-281. View Publication

Pappenheimer AM, Randall V. On the alleged high sensitivity of mouse Ehrlich-Lettre ascites tumor cells to diphtheria toxin. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):3149-52. PMID: 1059101; PMCID: PMC432938

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 115 publications over 39 distinct years, with a maximum of 10 publications in 1997

Bar chart showing 115 publications over 39 distinct years, with a maximum of 10 publications in 1997

Year	Publications
1981	1
1982	1
1984	1
1985	2
1987	1
1988	3
1989	3
1990	2
1991	3
1993	1
1994	6
1995	2
1996	1
1997	10
1998	8
1999	2
2000	7
2001	5
2002	4
2003	3
2004	2
2005	3
2006	3
2007	3
2008	3
2009	1
2010	2
2011	5
2012	3
2013	3
2014	4
2015	3
2016	1
2017	1
2018	2
2019	3
2020	3
2021	2
2022	2

2013 GMS Faculty Recognition Award

2010 Gold Fellow of ARVO (Association for Research in Vision and Ophthalmology)

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