Vickery Trinkaus-Randall, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Wisconsin Madison




Our laboratory is interested in the wound response and repair of epithelium, neurons and extracellular matrix. 1. In the healthy cornea there are no blood vessels and thus the tissue provides an excellent model to study the communication between nerves and epithelium following injury. Primary neurons are co-cultured with epithelial cells to ask how signaling pathways communicate. These include but are not limited to glutamatergic and purinergic receptor-mediated calcium transients. 2. In addition to these signaling events we have found that when epithelial cells are injured nucleotides are released immediately and cause a distinct phosphorylation of EGF receptor residues that ultimately affect the ability of a cell to migrate. 3. To study controlling factors on extracellular matrix or stromal formation we have developed scaffold-free long-term cultures and these have recently enabled us to study the role of hypoxia, which occurs in a diurnal pattern in this tissue as one sleeps. Our experiments are conducted using a number of organ culture and cell models and use biochemical, cell and molecular techniques. 4. Last but not least we are interested in the role of long sugar chains or glycosaminoglycans on the formation of oligomers and fibrils in light chain amyloid disease using atomic force microscopy, negative staining and biochemical technologies.

Professor
Boston University School of Medicine
Ophthalmology


Co-Director
Boston University School of Medicine, Graduate Medical Sciences
MD/PhD Program



2013 GMS Faculty Recognition Award
2010 Gold Fellow of ARVO (Association for Research in Vision and Ophthalmology)


Calcium oscillations and cell motility with corneal injury
02/01/2019 - 01/31/2021 (PI)
NIH/National Eye Institute
1R21EY029097-01A1

Molecular Mechanisms of corneal wound repair
09/30/2018 - 09/29/2019 (PI)
NIH/National Eye Institute
2R01EY006000-31

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2019 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Corneal Epithelial Adhesion: Morphology and Biochemistry
08/01/2014 - 09/29/2018 (PI)
NIH/National Eye Institute
5R01EY006000-30

Multicellular Regulation of Corneal Wound Healing
12/01/2014 - 11/30/2017 (PI)
NIH/National Eye Institute
5R21EY024392-02

Corneal Epithelial Adhesion: Morphology & Biochemistry
06/01/1986 - 05/31/2014 (PI)
NIH/National Eye Institute
5R01EY006000-26

Engineering Biomimetric Corneal Constructs
09/30/2009 - 09/29/2011 (PI)
Northeastern University NIH NEI
5R01EY015500-06

Purchase of a New Confocal Zeiss LSM 510v3.2
09/01/2005 - 08/31/2006 (PI)
NIH/National Center for Health Research Resources
1 S10 RR17967 01A2

Role of Growth Factors on Epidermal and Neuronal Injury
09/30/2000 - 08/31/2003 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R21 DK59753 02

Regulation of Extracellular Matrix in the Corneal Stroma
08/01/1996 - 07/31/2000 (Co-PI)
PI: Matthew A. Nugent, PhD
NIH/National Eye Institute
5 R01 EY11004 04




Yr Title Project-Sub Proj Pubs
2019 Calcium oscillations and cell motility with corneal injury 1R21EY029097-01A1
2018 Molecular Mechanisms of corneal wound repair 2R01EY006000-31 29
2017 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-30 29
2016 Multicellular regulation of corneal wound healing 5R21EY024392-02
2016 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-29 29
2015 Multicellular regulation of corneal wound healing 1R21EY024392-01A1
2015 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-28 29
2015 Corneal Epithelial Adhesion: Morphology and Biochemistry 3R01EY006000-28S1 29
2014 Corneal Epithelial Adhesion: Morphology and Biochemistry 2R01EY006000-27A1 29
2012 Corneal epithelial adhesion:morphology and biochemistry 5R01EY006000-26 29
Showing 10 of 56 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles. PMID: 31017899.
     
  2. Onochie OE, Onyejose AJ, Rich CB, Trinkaus-Randall V. The Role of Hypoxia in Corneal Extracellular Matrix Deposition and Cell Motility. Anat Rec (Hoboken). 2019 Mar 12.View Related Profiles. PMID: 30861330.
     
  3. Onochie OE, Zollinger A, Rich CB, Smith M, Trinkaus-Randall V. Epithelial cells exert differential traction stress in response to substrate stiffness. Exp Eye Res. 2019 Apr; 181:25-37.View Related Profiles. PMID: 30653966.
     
  4. Kneer K, Green MB, Meyer J, Rich CB, Minns MS, Trinkaus-Randall V. High fat diet induces pre-type 2 diabetes with regional changes in corneal sensory nerves and altered P2X7 expression and localization. Exp Eye Res. 2018 10; 175:44-55.View Related Profiles. PMID: 29883639; DOI: 10.1016/j.exer.2018.06.001;.
     
  5. Lee A, Karamichos D, Onochie OE, Hutcheon AEK, Rich CB, Zieske JD, Trinkaus-Randall V. Hypoxia modulates the development of a corneal stromal matrix model. Exp Eye Res. 2018 05; 170:127-137.View Related Profiles. PMID: 29496505.
     
  6. Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 Sep; 31(9):4117-4128.View Related Profiles. PMID: 28566470.
     
  7. Minns MS, Trinkaus-Randall V. Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors. J Ocul Pharmacol Ther. 2016 Oct; 32(8):498-503.View Related Profiles. PMID: 27643999.
     
  8. Minns MS, Teicher G, Rich CB, Trinkaus-Randall V. Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury. Am J Pathol. 2016 Feb; 186(2):285-96.View Related Profiles. PMID: 26683661; PMCID: PMC4729273; DOI: 10.1016/j.ajpath.2015.10.006;.
     
  9. Derricks KE, Trinkaus-Randall V, Nugent MA. Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb). 2015 Sep; 7(9):1011-25.View Related Profiles. PMID: 26183123; PMCID: PMC4558347; DOI: 10.1039/c5ib00140d;.
     
  10. Minns M, Teicher G, Rich CB, Trinkaus-Randall V. Experimental Biology Meeting. Inhibition of P2X7 Alters Wound-Induced Ca2+ Mobilization and Cytoskeletal Rearrangements. The FASEB Journal. 2015; 29.
Showing 10 of 110 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 108 publications over 36 distinct years, with a maximum of 10 publications in 1997

YearPublications
19811
19821
19841
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19893
19902
19913
19931
19946
19952
19961
199710
19988
19992
20007
20015
20024
20033
20042
20053
20063
20073
20083
20091
20102
20115
20123
20133
20144
20153
20161
20171
20182
20193
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72 E. Concord St Instructional (L)
Boston MA 02118
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