Shawn Lyons | Profiles RNS

Shawn Lyons, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of North Carolina at Chapel Hill
MS, New York University
BS, University of North Carolina at Chapel Hill

Websites

	Harvard Catalyst
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ORCID : 0000-0002-2289-6392

Shawn Lyons obtained his Ph.D. in the laboratory of Dr. William Marzluff at UNC working on histone mRNA metabolism. He was a postdoctoral fellow with Dr. Paul Anderson at Harvard Medical School (Brigham and Women’s) and worked on the regulation of protein synthesis during acute stress response in cells, in particular how RNA metabolism and ribosome biogenesis are altered in response to stress.

BU Research

Regulation of Ribosome Biogenesis
09/20/2022 - 08/31/2027 (PI)
NIH/National Institute of General Medical Sciences
5R35GM146769-02

Regulation of ribosome biogenesis during stress
02/01/2020 - 01/31/2023 (PI)
NIH/National Institute of General Medical Sciences
5R00GM124458-04

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Nelson EV, Ross SJ, Olejnik J, Hume AJ, Deeney DJ, King E, Grimins AO, Lyons SM, Cifuentes D, Mühlberger E. The 3' Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay. J Infect Dis. 2023 Nov 13; 228(Supplement_7):S488-S497.View Related Profiles.

Hume, Adam
Cifuentes, Daniel
Muhlberger, Elke
Nelson, Emily
Olejnik, Judith
Lyons, Shawn

PMID: 37551415; PMCID: PMC10651315; DOI: 10.1093/infdis/jiad312;

Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Am J Hum Genet. 2023 Oct 05; 110(10):1735-1749.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Werder, Rhiannon Bree
Lyons, Shawn

PMID: 37734371; PMCID: PMC10577075; DOI: 10.1016/j.ajhg.2023.08.017;

Reiss M, Keegan J, Aldrich A, Lyons SM, Flynn RL. The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA. FEBS Lett. 2023 Jul; 597(14):1818-1836.View Related Profiles.

Flynn, Rachel
Lyons, Shawn

PMID: 37191774; PMCID: PMC10524182; DOI: 10.1002/1873-3468.14639;

Paget M, Cadena C, Ahmad S, Wang HT, Jordan TX, Kim E, Koo B, Lyons SM, Ivanov P, tenOever B, Mu X, Hur S. Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA. Mol Cell. 2023 Apr 06; 83(7):1180-1196.e8. PMID: 37028415; PMCID: PMC10170497; DOI: 10.1016/j.molcel.2023.03.010;

Akiyama Y, Lyons SM, Fay MM, Tomioka Y, Abe T, Anderson PJ, Ivanov P. Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases. Front Mol Biosci. 2022; 9:791094. PMID: 35300117; PMCID: PMC8920990; DOI: 10.3389/fmolb.2022.791094;

Szaflarski W, Lesniczak-Staszak M, Sowinski M, Ojha S, Aulas A, Dave D, Malla S, Anderson P, Ivanov P, Lyons SM. Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity. Nucleic Acids Res. 2022 01 25; 50(2):1033-1051.View Related Profiles.

Ojha, Sandeep
Lyons, Shawn
Malla, Sulochan

PMID: 34928368; PMCID: PMC8789083; DOI: 10.1093/nar/gkab1231;

Fernandes N, Nero L, Lyons SM, Ivanov P, Mittelmeier TM, Bolger TA, Buchan JR. Correction: Fernandes et al. Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation. Biomolecules 2020, 10, 1367. Biomolecules. 2021 Dec 17; 11(12). PMID: 34944560; PMCID: PMC8699386; DOI: 10.3390/biom11121895;

Pietras P, Aulas A, Fay MM, Lesniczak-Staszak M, Sowinski M, Lyons SM, Szaflarski W, Ivanov P. Translation inhibition and suppression of stress granules formation by cisplatin. Biomed Pharmacother. 2022 Jan; 145:112382. PMID: 34864307; PMCID: PMC8782064; DOI: 10.1016/j.biopha.2021.112382;

Pietras P, Lesniczak-Staszak M, Kasprzak A, Andrzejewska M, Jopek K, Sowinski M, Rucinski M, Lyons SM, Ivanov P, Szaflarski W. MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. Int J Mol Sci. 2021 Nov 09; 22(22). PMID: 34829999; PMCID: PMC8623820; DOI: 10.3390/ijms222212121;

Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443.View Related Profiles.

Labadorf, Adam
Cifuentes, Daniel
Ganem, Neil
Flynn, Rachel
Lyons, Shawn

PMID: 34365507; PMCID: PMC8450105; DOI: 10.1093/nar/gkab647;

Showing 10 of 44 results. Show More

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;

Fernandes N, Nero L, Lyons SM, Ivanov P, Mittelmeier TM, Bolger TA, Buchan JR. Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation. Biomolecules. 2020 09 25; 10(10). PMID: 32992901; PMCID: PMC7650667; DOI: 10.3390/biom10101367;

Aulas A, Finetti P, Lyons SM, Bertucci F, Birnbaum D, Acquaviva C, Mamessier E. Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins? Cancers (Basel). 2020 Sep 01; 12(9). PMID: 32882814; PMCID: PMC7564653; DOI: 10.3390/cancers12092470;

Lyons SM, Kharel P, Akiyama Y, Ojha S, Dave D, Tsvetkov V, Merrick W, Ivanov P, Anderson P. eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function. Nucleic Acids Res. 2020 06 19; 48(11):6223-6233.View Related Profiles.

Ojha, Sandeep
Lyons, Shawn

PMID: 32374873; PMCID: PMC7293036; DOI: 10.1093/nar/gkaa336;

Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, Ito H, Alayo QA, Kharel P, Giantini Larsen A, Fan WY, Auduong S, Grauwet K, Passaro C, Khalsa JK, Shah K, Reardon DA, Ligon KL, Beroukhim R, Nakashima H, Ivanov P, Anderson PJ, Lawler SE, Chiocca EA. Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8. PMID: 32504554; PMCID: PMC7377926; DOI: 10.1016/j.molcel.2020.05.015;

Ojha S, Malla S, Lyons SM. snoRNPs: Functions in Ribosome Biogenesis. Biomolecules. 2020 05 18; 10(5).View Related Profiles.

Ojha, Sandeep
Lyons, Shawn
Malla, Sulochan

PMID: 32443616; PMCID: PMC7277114; DOI: 10.3390/biom10050783;

Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP. Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. Cell. 2020 04 16; 181(2):306-324.e28. PMID: 32302570; PMCID: PMC7816278; DOI: 10.1016/j.cell.2020.03.050;

Smith JA, Curry EG, Blue RE, Roden C, Dundon SER, Rodríguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb ME, Gladfelter AS, Giudice J. FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. J Cell Biol. 2020 04 06; 219(4). PMID: 32328638; PMCID: PMC7147106; DOI: 10.1083/jcb.201911129;

Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. Correction: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2020 Jan 06; 219(1). PMID: 31851327; PMCID: PMC7039196; DOI: 10.1083/jcb.20150802809202019c;

Gámbaro F, Li Calzi M, Fagúndez P, Costa B, Greif G, Mallick E, Lyons S, Ivanov P, Witwer K, Cayota A, Tosar JP. Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner. RNA Biol. 2020 08; 17(8):1168-1182. PMID: 31885318; PMCID: PMC7549683; DOI: 10.1080/15476286.2019.1708548;

Aulas A, Lyons SM, Fay MM, Anderson P, Ivanov P. Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability. Cell Death Dis. 2018 11 13; 9(11):1129. PMID: 30425239; PMCID: PMC6234215; DOI: 10.1038/s41419-018-1173-x;

Lyons SM, Fay MM, Ivanov P. The role of RNA modifications in the regulation of tRNA cleavage. FEBS Lett. 2018 09; 592(17):2828-2844. PMID: 30058219; PMCID: PMC6986807; DOI: 10.1002/1873-3468.13205;

Rodríguez-Saltos CA, Lyons SM, Sockman KW, Maney DL. Sound-induced monoaminergic turnover in the auditory forebrain depends on endocrine state in a seasonally-breeding songbird. J Neuroendocrinol. 2018 May 08; e12606. PMID: 29738608; PMCID: PMC6365208; DOI: 10.1111/jne.12606;

Lyons SM, Gudanis D, Coyne SM, Gdaniec Z, Ivanov P. Author Correction: Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs. Nat Commun. 2017 12 05; 8(1):2020. PMID: 29209051; PMCID: PMC5717102; DOI: 10.1038/s41467-017-02140-9;

Lyons SM, Gudanis D, Coyne SM, Gdaniec Z, Ivanov P. Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs. Nat Commun. 2017 10 24; 8(1):1127. PMID: 29066746; PMCID: PMC5655342; DOI: 10.1038/s41467-017-01278-w;

Sockman KW, Lyons SM. How Song Experience Affects Female Mate-Choice, Male Song, and Monoaminergic Activity in the Auditory Telencephalon in Lincoln's Sparrows. Integr Comp Biol. 2017 10 01; 57(4):891-901. PMID: 28992115; DOI: 10.1093/icb/icx080;

Fay MM, Lyons SM, Ivanov P. RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms. J Mol Biol. 2017 07 07; 429(14):2127-2147. PMID: 28554731; PMCID: PMC5603239; DOI: 10.1016/j.jmb.2017.05.017;

Lyons SM, Sockman KW. Sex Differences in Forebrain Monoaminergic Response to Song Performance. Brain Behav Evol. 2017; 89(3):219-230. PMID: 28482339; DOI: 10.1159/000471784;

Lyons SM, Fay MM, Akiyama Y, Anderson PJ, Ivanov P. RNA biology of angiogenin: Current state and perspectives. RNA Biol. 2017 02; 14(2):171-178. PMID: 28010172; PMCID: PMC5324756; DOI: 10.1080/15476286.2016.1272746;

Aulas A, Fay MM, Lyons SM, Achorn CA, Kedersha N, Anderson P, Ivanov P. Stress-specific differences in assembly and composition of stress granules and related foci. J Cell Sci. 2017 03 01; 130(5):927-937. PMID: 28096475; PMCID: PMC5358336; DOI: 10.1242/jcs.199240;

Lyons SM, Anderson P. RNA-Seeded Functional Amyloids Balance Growth and Survival. Dev Cell. 2016 10 24; 39(2):131-132. PMID: 27780035; PMCID: PMC5245099; DOI: 10.1016/j.devcel.2016.10.005;

Lyons SM, Cunningham CH, Welch JD, Groh B, Guo AY, Wei B, Whitfield ML, Xiong Y, Marzluff WF. A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues. Nucleic Acids Res. 2016 Nov 02; 44(19):9190-9205. PMID: 27402160; PMCID: PMC5100578; DOI: 10.1093/nar/gkw620;

Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI, Nakano I, Chiocca EA, Godlewski J, Bronisz A. The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 06 14; 15(11):2500-9. PMID: 27264189; PMCID: PMC4909547; DOI: 10.1016/j.celrep.2016.05.018;

Lyons SM, Achorn C, Kedersha NL, Anderson PJ, Ivanov P. YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression. Nucleic Acids Res. 2016 08 19; 44(14):6949-60. PMID: 27174937; PMCID: PMC5001593; DOI: 10.1093/nar/gkw418;

Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60. PMID: 27022092; PMCID: PMC4810302; DOI: 10.1083/jcb.201508028;

Johnson ME, Grassetti AV, Taroni JN, Lyons SM, Schweppe D, Gordon JK, Spiera RF, Lafyatis R, Anderson PJ, Gerber SA, Whitfield ML. Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis. Arthritis Res Ther. 2016 Jan 22; 18:27.View Related Profiles.

Lafyatis, Robert
Lyons, Shawn

PMID: 26801089; PMCID: PMC4724133; DOI: 10.1186/s13075-016-0914-4;

Brooks L, Lyons SM, Mahoney JM, Welch JD, Liu Z, Marzluff WF, Whitfield ML. A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs. RNA. 2015 Nov; 21(11):1943-65. PMID: 26377992; PMCID: PMC4604434; DOI: 10.1261/rna.053389.115;

Terzo EA, Lyons SM, Poulton JS, Temple BR, Marzluff WF, Duronio RJ. Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body. Mol Biol Cell. 2015 Apr 15; 26(8):1559-74. PMID: 25694448; PMCID: PMC4395134; DOI: 10.1091/mbc.E14-10-1445;

Lyons SM, Beaulieu M, Sockman KW. Contrast influences female attraction to performance-based sexual signals in a songbird. Biol Lett. 2014 Oct; 10(10):20140588. PMID: 25319818; PMCID: PMC4272206; DOI: 10.1098/rsbl.2014.0588;

Lyons SM, Ricciardi AS, Guo AY, Kambach C, Marzluff WF. The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation. RNA. 2014 Jan; 20(1):88-102. PMID: 24255165; PMCID: PMC3866647; DOI: 10.1261/rna.042531.113;

Su W, Slepenkov SV, Slevin MK, Lyons SM, Ziemniak M, Kowalska J, Darzynkiewicz E, Jemielity J, Marzluff WF, Rhoads RE. mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end. RNA. 2013 Jan; 19(1):1-16. PMID: 23188809; PMCID: PMC3527721; DOI: 10.1261/rna.034470.112;

Martin L, Meier M, Lyons SM, Sit RV, Marzluff WF, Quake SR, Chang HY. Systematic reconstruction of RNA functional motifs with high-throughput microfluidics. Nat Methods. 2012 Dec; 9(12):1192-4. PMID: 23142872; PMCID: PMC3863600; DOI: 10.1038/nmeth.2225;

Yang T, Lyons S, Aguilar C, Cuhel R, Teske A. Microbial communities and chemosynthesis in yellowstone lake sublacustrine hydrothermal vent waters. Front Microbiol. 2011; 2:130. PMID: 21716640; PMCID: PMC3116135; DOI: 10.3389/fmicb.2011.00130;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 44 publications over 13 distinct years, with a maximum of 9 publications in 2020

Bar chart showing 44 publications over 13 distinct years, with a maximum of 9 publications in 2020

Year	Publications
2011	1
2012	2
2013	1
2014	1
2015	2
2016	6
2017	7
2018	3
2019	1
2020	9
2021	5
2022	2
2023	4

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