Shawn Lyons, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, University of North Carolina at Chapel Hill
MS, New York University
BS, University of North Carolina at Chapel Hill

Shawn Lyons obtained his Ph.D. in the laboratory of Dr. William Marzluff at UNC working on histone mRNA metabolism. He was a postdoctoral fellow with Dr. Paul Anderson at Harvard Medical School (Brigham and Women’s) and worked on the regulation of protein synthesis during acute stress response in cells, in particular how RNA metabolism and ribosome biogenesis are altered in response to stress.

Regulation of Ribosome Biogenesis
09/20/2022 - 08/31/2027 (PI)
NIH/National Institute of General Medical Sciences

Regulation of ribosome biogenesis during stress
02/01/2020 - 01/31/2023 (PI)
NIH/National Institute of General Medical Sciences


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Nelson EV, Ross SJ, Olejnik J, Hume AJ, Deeney DJ, King E, Grimins AO, Lyons SM, Cifuentes D, Mühlberger E. The 3' Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay. J Infect Dis. 2023 Nov 13; 228(Supplement_7):S488-S497.View Related Profiles. PMID: 37551415; PMCID: PMC10651315; DOI: 10.1093/infdis/jiad312;
  2. Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Am J Hum Genet. 2023 Oct 05; 110(10):1735-1749.View Related Profiles. PMID: 37734371; PMCID: PMC10577075; DOI: 10.1016/j.ajhg.2023.08.017;
  3. Reiss M, Keegan J, Aldrich A, Lyons SM, Flynn RL. The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA. FEBS Lett. 2023 Jul; 597(14):1818-1836.View Related Profiles. PMID: 37191774; PMCID: PMC10524182; DOI: 10.1002/1873-3468.14639;
  4. Paget M, Cadena C, Ahmad S, Wang HT, Jordan TX, Kim E, Koo B, Lyons SM, Ivanov P, tenOever B, Mu X, Hur S. Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA. Mol Cell. 2023 Apr 06; 83(7):1180-1196.e8. PMID: 37028415; PMCID: PMC10170497; DOI: 10.1016/j.molcel.2023.03.010;
  5. Akiyama Y, Lyons SM, Fay MM, Tomioka Y, Abe T, Anderson PJ, Ivanov P. Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases. Front Mol Biosci. 2022; 9:791094. PMID: 35300117; PMCID: PMC8920990; DOI: 10.3389/fmolb.2022.791094;
  6. Szaflarski W, Lesniczak-Staszak M, Sowinski M, Ojha S, Aulas A, Dave D, Malla S, Anderson P, Ivanov P, Lyons SM. Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity. Nucleic Acids Res. 2022 01 25; 50(2):1033-1051.View Related Profiles. PMID: 34928368; PMCID: PMC8789083; DOI: 10.1093/nar/gkab1231;
  7. Fernandes N, Nero L, Lyons SM, Ivanov P, Mittelmeier TM, Bolger TA, Buchan JR. Correction: Fernandes et al. Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation. Biomolecules 2020, 10, 1367. Biomolecules. 2021 Dec 17; 11(12). PMID: 34944560; PMCID: PMC8699386; DOI: 10.3390/biom11121895;
  8. Pietras P, Aulas A, Fay MM, Lesniczak-Staszak M, Sowinski M, Lyons SM, Szaflarski W, Ivanov P. Translation inhibition and suppression of stress granules formation by cisplatin. Biomed Pharmacother. 2022 Jan; 145:112382. PMID: 34864307; PMCID: PMC8782064; DOI: 10.1016/j.biopha.2021.112382;
  9. Pietras P, Lesniczak-Staszak M, Kasprzak A, Andrzejewska M, Jopek K, Sowinski M, Rucinski M, Lyons SM, Ivanov P, Szaflarski W. MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. Int J Mol Sci. 2021 Nov 09; 22(22). PMID: 34829999; PMCID: PMC8623820; DOI: 10.3390/ijms222212121;
  10. Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443.View Related Profiles. PMID: 34365507; PMCID: PMC8450105; DOI: 10.1093/nar/gkab647;
Showing 10 of 44 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 44 publications over 13 distinct years, with a maximum of 9 publications in 2020


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