Raghuveera Goel, PhD

A major focus of my research lies on identifying and characterizing unique molecular drivers of lung and breast cancer using relevant in vitro and in vivo models. Unlike normal/ healthy cells, cancer cells deploy evasive and complex signaling modules to overcome negative selective pressures thereby facilitating malignant progression. To gain a better understanding of the cancer-specific signaling landscape my research involves the implementation of systematic and multi-tiered quantitative proteomics approaches to holistically capture the biological state of cells at a sub-cellular resolution. Another highly important and novel facet of my work relates to the implementation of proximity labeling tools to quantitatively and qualitatively profile cell-to-cell communication both in healthy and cancer cells. Together using robust statistical models of data integration, the overarching goal of my research in cancer biology lies on identifying candidate targets for novel cancer therapies.

In parallel, I am applying these omic technologies to study the global signaling networks altered in obesity/diabetes contexts and their connection with breast cancer. Large cohort studies have provided substantial evidence linking obesity with the risks of breast cancer. My studies aim to decipher the molecular links between the pathophysiology of adipose tissue and breast cancer progression. Apart from engaging in multi-omics/systems-level research in the lab, I tremendously enjoy mentoring/teaching. In addition to mentoring in the lab I have led numerous national science outreach efforts in Canada to promote STEM interest among the youth. At the Emili lab I continue to engage myself in cutting-edge research and imparting knowledge through teaching/mentoring.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Miah S, Bagu E, Goel R, Ogunbolude Y, Dai C, Ward A, Vizeacoumar FS, Davies G, Vizeacoumar FJ, Anderson D, Lukong KE. Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells. BMC Cancer. 2019 Jan 16; 19(1):78. PMID: 30651078
     
  2. Alam MW, Wahid KA, Goel RK, Lukong KE. Development of a low-cost and portable smart fluorometer for detecting breast cancer cells. Biomed Opt Express. 2019 Feb 01; 10(2):399-410. PMID: 30800488
     
  3. Goel RK, Meyer M, Paczkowska M, Reimand J, Vizeacoumar F, Vizeacoumar F, Lam TT, Lukong KE. Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates. Proteome Sci. 2018; 16:16. PMID: 30140170
     
  4. Goel RK, Paczkowska M, Reimand J, Napper S, Lukong KE. Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS). Mol Cell Proteomics. 2018 05; 17(5):925-947. PMID: 29496907
     
  5. Ogunbolude Y, Dai C, Bagu ET, Goel RK, Miah S, MacAusland-Berg J, Ng CY, Chibbar R, Napper S, Raptis L, Vizeacoumar F, Vizeacoumar F, Bonham K, Lukong KE. FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition. Oncotarget. 2017 Dec 22; 8(68):113034-113065. PMID: 29348886
     
  6. Nwabo Kamdje AH, Kamga PT, Simo RT, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Goel RK, Amvene JM, Krampera M. Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer Biol Med. 2017 May; 14(2):129-141. PMID: 28607804
     
  7. Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, Sanders M, Goel RK, Bonham K, Lukong KE. Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget. 2017 Feb 14; 8(7):11442-11459. PMID: 28077797
     
  8. Goel RK, Lukong KE. Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology. Cancer Metastasis Rev. 2016 06; 35(2):179-99. PMID: 27067725
     
  9. Goel RK, Lukong KE. Tracing the footprints of the breast cancer oncogene BRK - Past till present. Biochim Biophys Acta. 2015 Aug; 1856(1):39-54. PMID: 25999240
     
  10. Miah S, Goel RK, Dai C, Kalra N, Beaton-Brown E, Bagu ET, Bonham K, Lukong KE. BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration. PLoS One. 2014; 9(2):e87684. PMID: 24523872
     
Showing 10 of 11 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 3 publications in 2017

YearPublications
20131
20141
20151
20161
20173
20182
20192

Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
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