Raghuveera Goel, PhD

A major focus of my research lies on identifying and characterizing unique molecular drivers of lung and breast cancer using relevant in vitro and in vivo models. Unlike normal/ healthy cells, cancer cells deploy evasive and complex signaling modules to overcome negative selective pressures thereby facilitating malignant progression. To gain a better understanding of the cancer-specific signaling landscape my research involves the implementation of systematic and multi-tiered quantitative proteomics approaches to holistically capture the biological state of cells at a sub-cellular resolution. Another highly important and novel facet of my work relates to the implementation of proximity labeling tools to quantitatively and qualitatively profile cell-to-cell communication both in healthy and cancer cells. Together using robust statistical models of data integration, the overarching goal of my research in cancer biology lies on identifying candidate targets for novel cancer therapies.

In parallel, I am applying these omic technologies to study the global signaling networks altered in obesity/diabetes contexts and their connection with breast cancer. Large cohort studies have provided substantial evidence linking obesity with the risks of breast cancer. My studies aim to decipher the molecular links between the pathophysiology of adipose tissue and breast cancer progression. Apart from engaging in multi-omics/systems-level research in the lab, I tremendously enjoy mentoring/teaching. In addition to mentoring in the lab I have led numerous national science outreach efforts in Canada to promote STEM interest among the youth. At the Emili lab I continue to engage myself in cutting-edge research and imparting knowledge through teaching/mentoring.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854
     
  2. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; DOI: 10.1016/j.molcel.2020.11.028;
     
  3. Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway. bioRxiv. 2020 Oct 28.View Related Profiles. PMID: 33140044
     
  4. Miah S, Bagu E, Goel R, Ogunbolude Y, Dai C, Ward A, Vizeacoumar FS, Davies G, Vizeacoumar FJ, Anderson D, Lukong KE. Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells. BMC Cancer. 2019 Jan 16; 19(1):78. PMID: 30651078
     
  5. Alam MW, Wahid KA, Goel RK, Lukong KE. Development of a low-cost and portable smart fluorometer for detecting breast cancer cells. Biomed Opt Express. 2019 Feb 01; 10(2):399-410. PMID: 30800488
     
  6. Goel RK, Meyer M, Paczkowska M, Reimand J, Vizeacoumar F, Vizeacoumar F, Lam TT, Lukong KE. Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates. Proteome Sci. 2018; 16:16. PMID: 30140170
     
  7. Goel RK, Paczkowska M, Reimand J, Napper S, Lukong KE. Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS). Mol Cell Proteomics. 2018 05; 17(5):925-947. PMID: 29496907
     
  8. Ogunbolude Y, Dai C, Bagu ET, Goel RK, Miah S, MacAusland-Berg J, Ng CY, Chibbar R, Napper S, Raptis L, Vizeacoumar F, Vizeacoumar F, Bonham K, Lukong KE. FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition. Oncotarget. 2017 Dec 22; 8(68):113034-113065. PMID: 29348886
     
  9. Nwabo Kamdje AH, Kamga PT, Simo RT, Vecchio L, Seke Etet PF, Muller JM, Bassi G, Lukong E, Goel RK, Amvene JM, Krampera M. Mesenchymal stromal cells' role in tumor microenvironment: involvement of signaling pathways. Cancer Biol Med. 2017 May; 14(2):129-141. PMID: 28607804
     
  10. Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, Sanders M, Goel RK, Bonham K, Lukong KE. Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget. 2017 Feb 14; 8(7):11442-11459. PMID: 28077797
     
Showing 10 of 14 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 14 publications over 9 distinct years, with a maximum of 3 publications in 2017

YearPublications
20131
20141
20151
20161
20173
20182
20192
20202
20211

Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
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