Olga Gursky, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Brandeis University
MS, Moscow State University




Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis.

Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability.

A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.

Member
Boston University
Amyloidosis Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Structure and Function of Serum Amyloid A in Health and Disease
01/01/2020 - 12/31/2023 (PI)
NIH/National Institute of General Medical Sciences
1R01GM135158-01

Apolipoprotein conformation in amyloid and cardiovascular diseases
09/15/2017 - 08/31/2021 (PI)
NIH/National Institute of General Medical Sciences
5R01GM067260-18

Structural Stability and Functional Remodeling of High-density Lipoproteins
07/01/2016 - 09/14/2017 (PI)
NIH/National Institute of General Medical Sciences
4R01GM067260-14

Structural Stability and Functional Remodeling of High-density Lipoproteins
09/01/2013 - 06/30/2016 (PI)
NIH/National Institute of General Medical Sciences
3R01GM067260-13S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/20/2002 - 05/31/2008 (PI)
NIH/National Institute of General Medical Sciences
3 R01 GM67260 08S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/15/1998 - 11/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R29 HL61429 04



Title


Yr Title Project-Sub Proj Pubs
2020 Structure and Function of Serum Amyloid A in Health and Disease 1R01GM135158-01
2020 Apolipoprotein conformation in Amyloid and Cardiovascular disease 3R01GM067260-17S1 55
2020 Apolipoprotein conformation in amyloid and cardiovascular diseases 5R01GM067260-18 55
2019 Apolipoprotein conformation in amyloid and cardiovascular diseases 5R01GM067260-17 55
2018 Apolipoprotein conformation in amyloid and cardiovascular diseases 5R01GM067260-16 55
2017 Apolipoprotein conformation in amyloid and cardiovascular diseases 2R01GM067260-15 55
2016 Structural stability and functional remodeling of high-density lipoproteins 4R01GM067260-14 55
2015 Structural stability and functional remodeling of high-density lipoproteins 5R01GM067260-13 55
2015 Structural stability and functional remodeling of high-density lipoproteins 3R01GM067260-13S1 55
2014 Structural stability and functional remodeling of high-density lipoproteins 5R01GM067260-12 55
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Gursky O. Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve. Curr Atheroscler Rep. 2020 Sep 24; 22(11):69. PMID: 32968930
     
  2. Gursky O. Novel clinical manifestations and treatment of hereditary apoA-I amyloidosis: when a good protein turns bad. Kidney Int. 2020 07; 98(1):62-64. PMID: 32571494
     
  3. Jayaraman S, Chavez OR, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug; 1865(8):158712.View Related Profiles. PMID: 32289504
     
  4. Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A. J Mol Biol. 2020 03 27; 432(7):1978-1995.View Related Profiles. PMID: 32035904
     
  5. Jayaraman S, Fändrich M, Gursky O. Synergy between serum amyloid A and secretory phospholipase A2. Elife. 2019 05 21; 8.View Related Profiles. PMID: 31111824
     
  6. Jayaraman S, Baveghems C, Chavez OR, Rivas-Urbina A, Sánchez-Quesada JL, Gursky O. Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 07; 1864(7):1061-1071.View Related Profiles. PMID: 30844432
     
  7. Morgado I, Panahi A, Burwash AG, Das M, Straub JE, Gursky O. Molecular Insights into Human Hereditary Apolipoprotein A-I Amyloidosis Caused by the Glu34Lys Mutation. Biochemistry. 2018 10 02; 57(39):5738-5747.View Related Profiles. PMID: 30184436
     
  8. Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR. Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry. 2018 07 31; 57(30):4583-4596.View Related Profiles. PMID: 30004693
     
  9. Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6428-E6436.View Related Profiles. PMID: 29941560
     
  10. Jayaraman S, Gantz DL, Haupt C, Fändrich M, Gursky O. Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner. Chem Commun (Camb). 2018 Apr 03; 54(28):3532-3535.View Related Profiles. PMID: 29565436
     
Showing 10 of 84 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 83 publications over 27 distinct years, with a maximum of 6 publications in 2015 and 2016

YearPublications
19892
19923
19943
19962
19981
19991
20002
20011
20022
20034
20041
20055
20062
20075
20083
20092
20103
20114
20125
20133
20142
20156
20166
20175
20184
20192
20204


I have the expertise to mentor pre- and post-doctoral trainees in fundamental research and its application to cardiovascular, metabolic and amyloid diseases. Our laboratory is fully committed to attracting and retaining women and minorities in science, includes two T32-supported members who are URM, and is known for its supportive family-friendly atmosphere. Our trainees master quantitative biophysical, biochemical and structural biology techniques. They benefit from our local, national and international collaborations in cell, molecular and structural biology, including cutting-edge methods in mass spectrometry, computational biology, and clinical studies. These collaborations greatly enrich the training experience. All trainees are active in teaching at the undergraduate or graduate levels, and are actively obtaining funding for research and conference travel. Our past trainees have received multiple Young Investigator Awards from the Protein Society, Gordon conferences and other venues. All our trainees have multiple publications in peer-reviewed journals. All trainees have moved on to their own successful careers in life sciences, including industry, academia, consulting and venture capital.

My commitment to graduate students’ mentoring is evident from my service for nearly 20 years on the Students Admissions and Affairs Committee in the Department; 5 years on MD/PhD admissions committee at the Boston University School of Medicine; 15 years on Students Achievement Day committee. I also serve on the Admissions Committee for the Program in Biological Sciences (PiBS), an umbrella program in Graduate Medical Sciences at the School of Medicine. I have years of service as a facilitator of the NIH-mandated Responsible Conduct of Research training; on students’ ethics violations committees; on approximately 50 PhD thesis defense committees, and on PhD qualifying exams for over 50 students. For years, I have been teaching three graduate-level courses at the department and the school.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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