Olga Gursky | Profiles RNS

Olga Gursky, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Brandeis University
MS, Moscow State University

Websites

	Pharmacology, Physiology & Biophysics Faculty
	Whitaker Cardiovascular Institute Training Program
	ResearchGate

ORCID : 0000-0002-8598-4824

Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis.

Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability.

A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.

Member
Boston University
Amyloidosis Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Structure and Function of Serum Amyloid A in Health and Disease
03/01/2024 - 12/31/2027 (PI)
NIH/National Institute of General Medical Sciences
3R01GM135158-05S1

Apolipoprotein conformation in amyloid and cardiovascular diseases
09/01/2021 - 08/31/2025 (PI)
NIH/National Institute of General Medical Sciences
3R01GM067260-21S1

Structure and Function of Serum Amyloid A in Health and Disease
01/01/2020 - 02/29/2024 (PI)
NIH/National Institute of General Medical Sciences
5R01GM135158-04

Apolipoprotein conformation in amyloid and cardiovascular diseases
09/15/2017 - 08/31/2021 (PI)
NIH/National Institute of General Medical Sciences
5R01GM067260-18

Structural Stability and Functional Remodeling of High-density Lipoproteins
07/01/2016 - 09/14/2017 (PI)
NIH/National Institute of General Medical Sciences
4R01GM067260-14

Structural and biochemical basis of protein amyloid evolution
08/01/2014 - 07/31/2017 (Key Person / Mentor)
University of Algarve EU Com/Marie Curie F

Structural Stability and Functional Remodeling of High-density Lipoproteins
09/01/2013 - 06/30/2016 (PI)
NIH/National Institute of General Medical Sciences
3R01GM067260-13S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/20/2002 - 05/31/2008 (PI)
NIH/National Institute of General Medical Sciences
3 R01 GM67260 08S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/15/1998 - 11/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R29 HL61429 04

Title

Yr	Title	Project-Sub Proj
2024	Structure and Function of Serum Amyloid A in Health and Disease	2R01GM135158-05
2024	Structure and Function of Serum Amyloid A in Health and Disease	3R01GM135158-05S1
2023	Structure and Function of Serum Amyloid A in Health and Disease	5R01GM135158-04
2023	Apolipoprotein conformation in amyloid and cardiovascular diseases	5R01GM067260-21
2023	Apolipoprotein conformation in amyloid and cardiovascular diseases	3R01GM067260-21S1
2023	Apolipoprotein conformation in amyloid and cardiovascular diseases	3R01GM067260-20S1
2022	Structure and Function of Serum Amyloid A in Health and Disease	3R01GM135158-03S2
2022	Structure and Function of Serum Amyloid A in Health and Disease	5R01GM135158-03
2022	Structure and Function of Serum Amyloid A in Health and Disease	3R01GM135158-03S1
2022	Apolipoprotein conformation in amyloid and cardiovascular diseases	5R01GM067260-20

Showing 10 of 38 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Lewkowicz E, Jayaraman S, Gursky O. Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers. Biomater Sci. 2024 Jul 24.View Related Profiles.

Lewkowicz, Emily
Gursky, Olga
Jayaraman, Shobini

PMID: 39046441

Jayaraman S, Narula N, Narula J, Gursky O. Amyloid and collagen templates in aortic valve calcification. Trends Mol Med. 2024 May 21.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 38845326

Lewkowicz E, Nakamura MN, Rynkiewicz MJ, Gursky O. Molecular modeling of apoE in complexes with Alzheimer's amyloid-ß fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cell Mol Life Sci. 2023 Nov 27; 80(12):376.View Related Profiles.

Lewkowicz, Emily
Rynkiewicz, Michael
Gursky, Olga

PMID: 38010414; PMCID: PMC11061799; DOI: 10.1007/s00018-023-05026-w;

Jayaraman S, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery. J Lipid Res. 2023 Nov; 64(11):100451.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 37777014; PMCID: PMC10665669; DOI: 10.1016/j.jlr.2023.100451;

Jayaraman S, Urdaneta A, Bullitt E, Fändrich M, Gursky O. Lipid clearance and amyloid formation by serum amyloid A: exploring the links between beneficial and pathologic actions of an enigmatic protein. J Lipid Res. 2023 Sep; 64(9):100429.View Related Profiles.

Bullitt, Esther
Gursky, Olga
Jayaraman, Shobini

PMID: 37604227; PMCID: PMC10509712; DOI: 10.1016/j.jlr.2023.100429;

Lewkowicz, Emily
Rynkiewicz, Michael
Gursky, Olga

PMID: 37577501; PMCID: PMC10418262; DOI: 10.1101/2023.08.04.551703;

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J. Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis. Nat Rev Cardiol. 2023 Jun; 20(6):429. PMID: 36807395

Klimtchuk ES, Peterle D, Bullitt E, Connors LH, Engen JR, Gursky O. Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin ?1 light chains. Amyloid. 2023 Dec; 30(4):364-378.View Related Profiles.

Klimtchuk, Elena
Bullitt, Esther
Connors, Lawreen
Gursky, Olga

PMID: 37216473; PMCID: PMC10663386; DOI: 10.1080/13506129.2023.2212397;

Klimtchuk ES, Peterle D, Bullitt EA, Connors LH, Engen JR, Gursky O. Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin ?1 Light Chains. bioRxiv. 2023 Feb 03.View Related Profiles.

Klimtchuk, Elena
Connors, Lawreen
Gursky, Olga

PMID: 36778378; PMCID: PMC9915687; DOI: 10.1101/2023.02.01.526662;

Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J. The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis. Nat Rev Cardiol. 2023 Jun; 20(6):418-428. PMID: 36624274; PMCID: PMC10199673; DOI: 10.1038/s41569-022-00818-2;

Showing 10 of 99 results. Show More

Brender JR, Ramamoorthy A, Gursky O, Bhunia A. Intrinsic disorder and structural biology: Searching where the light isn't. Biophys Chem. 2023 Jan; 292:106912. PMID: 36335754

Peterle D, Klimtchuk ES, Wales TE, Georgescauld F, Connors LH, Engen JR, Gursky O. A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin ?6 Light Chain Promotes Pathologic Amyloid Formation. J Mol Biol. 2021 12 03; 433(24):167310.View Related Profiles.

Klimtchuk, Elena
Connors, Lawreen
Gursky, Olga

PMID: 34678302; PMCID: PMC8627465; DOI: 10.1016/j.jmb.2021.167310;

Lewkowicz E, Gursky O. Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis. Biophys Chem. 2022 01; 280:106699.View Related Profiles.

Lewkowicz, Emily
Gursky, Olga

PMID: 34773861; PMCID: PMC9416430; DOI: 10.1016/j.bpc.2021.106699;

Jayaraman S, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Heparin binding triggers human VLDL remodeling by circulating lipoprotein lipase: Relevance to VLDL functionality in health and disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 01; 1867(1):159064.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 34610468; PMCID: PMC8595799; DOI: 10.1016/j.bbalip.2021.159064;

Lewkowicz E, Jayaraman S, Gursky O. Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match? Trends Biochem Sci. 2021 08; 46(8):626-629.View Related Profiles.

Lewkowicz, Emily
Gursky, Olga
Jayaraman, Shobini

PMID: 34210544; PMCID: PMC8415129; DOI: 10.1016/j.tibs.2021.05.003;

Gursky O. Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve. Curr Atheroscler Rep. 2020 09 24; 22(11):69. PMID: 32968930; PMCID: PMC7511256; DOI: 10.1007/s11883-020-00888-y;

Gursky O. Novel clinical manifestations and treatment of hereditary apoA-I amyloidosis: when a good protein turns bad. Kidney Int. 2020 07; 98(1):62-64. PMID: 32571494; PMCID: PMC8423090; DOI: 10.1016/j.kint.2020.03.030;

Jayaraman S, Chavez OR, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 08; 1865(8):158712.View Related Profiles.

Gursky, Olga
Chavez, Olivia
Jayaraman, Shobini

PMID: 32289504; PMCID: PMC7269877; DOI: 10.1016/j.bbalip.2020.158712;

Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A. J Mol Biol. 2020 03 27; 432(7):1978-1995.View Related Profiles.

Straub, John
Frame, Nicholas
Gursky, Olga

PMID: 32035904; PMCID: PMC7225066; DOI: 10.1016/j.jmb.2020.01.029;

Jayaraman S, Fändrich M, Gursky O. Synergy between serum amyloid A and secretory phospholipase A2. Elife. 2019 05 21; 8.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 31111824; PMCID: PMC6557629; DOI: 10.7554/eLife.46630;

Jayaraman S, Baveghems C, Chavez OR, Rivas-Urbina A, Sánchez-Quesada JL, Gursky O. Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 07; 1864(7):1061-1071.View Related Profiles.

Gursky, Olga
Chavez, Olivia
Jayaraman, Shobini

PMID: 30844432; PMCID: PMC6482102; DOI: 10.1016/j.bbalip.2019.03.001;

Morgado I, Panahi A, Burwash AG, Das M, Straub JE, Gursky O. Molecular Insights into Human Hereditary Apolipoprotein A-I Amyloidosis Caused by the Glu34Lys Mutation. Biochemistry. 2018 10 02; 57(39):5738-5747.View Related Profiles.

Straub, John
Das, Madhurima
Gursky, Olga

PMID: 30184436

Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR. Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry. 2018 07 31; 57(30):4583-4596.View Related Profiles.

Das, Madhurima
Gursky, Olga
Jayaraman, Shobini

PMID: 30004693; PMCID: PMC6067968; DOI: 10.1021/acs.biochem.8b00538;

Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6428-E6436.View Related Profiles.

Klimtchuk, Elena
Berk, John
Connors, Lawreen
Frame, Nicholas
Gursky, Olga
Prokaeva, Tatiana

PMID: 29941560; PMCID: PMC6048550; DOI: 10.1073/pnas.1802977115;

Jayaraman S, Gantz DL, Haupt C, Fändrich M, Gursky O. Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner. Chem Commun (Camb). 2018 Apr 03; 54(28):3532-3535.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 29565436; PMCID: PMC5882536; DOI: 10.1039/C8CC01424H;

Madico G, Gursky O, Fairman J, Massari P. Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens. Vaccines (Basel). 2017 Dec 25; 6(1).View Related Profiles.

Gursky, Olga
Massari, Paola

PMID: 29295593; PMCID: PMC5874643; DOI: 10.3390/vaccines6010002;

Prokaeva T, Akar H, Spencer B, Havasi A, Cui H, O'Hara CJ, Gursky O, Leszyk J, Steffen M, Browning S, Rosenberg A, Connors LH. Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant. Kidney Int Rep. 2017 Nov; 2(6):1223-1232.View Related Profiles.

Rosenberg, Allison
Havasi, Andrea
O'Hara, Carl
Connors, Lawreen
Steffen, Martin
Gursky, Olga
Browning, Sabrina
Prokaeva, Tatiana

PMID: 29270531; PMCID: PMC5733886; DOI: 10.1016/j.ekir.2017.07.009;

Jayaraman S, Gantz DL, Haupt C, Gursky O. Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6507-E6515.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 28743750; PMCID: PMC5559045; DOI: 10.1073/pnas.1707120114;

Frame NM, Jayaraman S, Gantz DL, Gursky O. Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response. J Struct Biol. 2017 Dec; 200(3):293-302.View Related Profiles.

Frame, Nicholas
Gursky, Olga
Jayaraman, Shobini

PMID: 28645735; PMCID: PMC6042646; DOI: 10.1016/j.jsb.2017.06.007;

Klimtchuk ES, Prokaeva TB, Spencer BH, Gursky O, Connors LH. In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid. 2017 Jun; 24(2):115-122.View Related Profiles.

Klimtchuk, Elena
Connors, Lawreen
Gursky, Olga
Prokaeva, Tatiana

PMID: 28632419; PMCID: PMC5580339; DOI: 10.1080/13506129.2017.1336996;

Frame NM, Gursky O. Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. Amyloid. 2017 Mar; 24(sup1):13-14.View Related Profiles.

Frame, Nicholas
Gursky, Olga

PMID: 28042712; PMCID: PMC5567814; DOI: 10.1080/13506129.2016.1270930;

Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? Amyloid. 2017 Mar; 24(sup1):11-12.View Related Profiles.

Das, Madhurima
Gursky, Olga
Mei, Xiaohu

PMID: 28042708; PMCID: PMC5557347; DOI: 10.1080/13506129.2016.1269737;

Jayaraman S, Sánchez-Quesada JL, Gursky O. Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases. Biochim Biophys Acta Mol Basis Dis. 2017 01; 1863(1):200-210.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 27768903; PMCID: PMC5154891; DOI: 10.1016/j.bbadis.2016.10.010;

Jayaraman S, Haupt C, Gursky O. Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA. J Lipid Res. 2016 Dec; 57(12):2138-2149.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 27744369; PMCID: PMC5321215; DOI: 10.1194/jlr.M071191;

Rull A, Jayaraman S, Gantz DL, Rivas-Urbina A, Pérez-Cuellar M, Ordóñez-Llanos J, Sánchez-Quesada JL, Gursky O. Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation. Biochim Biophys Acta. 2016 09; 1861(9 Pt A):1015-24.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 27233433; PMCID: PMC5572826; DOI: 10.1016/j.bbalip.2016.05.008;

Frame NM, Gursky O. Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. FEBS Lett. 2016 Mar; 590(6):866-79.View Related Profiles.

Frame, Nicholas
Gursky, Olga

PMID: 26918388; PMCID: PMC4805461; DOI: 10.1002/1873-3468.12116;

Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O. Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? J Mol Biol. 2016 Jan 29; 428(2 Pt B):449-62.View Related Profiles.

Das, Madhurima
Gursky, Olga
Mei, Xiaohu

PMID: 26562506; PMCID: PMC4744490; DOI: 10.1016/j.jmb.2015.10.029;

Jayaraman S, Haupt C, Gursky O. Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL. J Lipid Res. 2015 Aug; 56(8):1531-42.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 26022803; PMCID: PMC4513994; DOI: 10.1194/jlr.M059162;

Gursky O. Structural stability and functional remodeling of high-density lipoproteins. FEBS Lett. 2015 Sep 14; 589(19 Pt A):2627-39. PMID: 25749369; PMCID: PMC4561042; DOI: 10.1016/j.febslet.2015.02.028;

Gursky, Olga. Advances in Experimental Medicine and Biology, 855. Lipids in Protein Misfolding. Springer. 2015. View Publication

Das M, Gursky O. Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights. Adv Exp Med Biol. 2015; 855:175-211.View Related Profiles.

Das, Madhurima
Gursky, Olga

PMID: 26149931; PMCID: PMC5610898; DOI: 10.1007/978-3-319-17344-3_8;

Gursky O. Preface. Role of lipids in protein misfolding. Adv Exp Med Biol. 2015; 855:v-vii. PMID: 26460399

Das M, Mei X, Jayaraman S, Atkinson D, Gursky O. Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. FEBS J. 2014 Jun; 281(11):2525-42.View Related Profiles.

Atkinson, David
Das, Madhurima
Gursky, Olga
Jayaraman, Shobini
Mei, Xiaohu

PMID: 24702826; PMCID: PMC4047191; DOI: 10.1111/febs.12809;

Gursky O. Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men. FEBS Lett. 2014 Mar 18; 588(6):845-50. PMID: 24561203; PMCID: PMC3979420; DOI: 10.1016/j.febslet.2014.01.066;

Lu M, Gursky O. Aggregation and fusion of low-density lipoproteins in vivo and in vitro. Biomol Concepts. 2013 Oct; 4(5):501-18.View Related Profiles.

Lu, Mengxiao
Gursky, Olga

PMID: 25197325; PMCID: PMC4154560; DOI: 10.1515/bmc-2013-0016;

Gursky O, Jones MK, Mei X, Segrest JP, Atkinson D. Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I. J Lipid Res. 2013 Dec; 54(12):3244-57.View Related Profiles.

Atkinson, David
Gursky, Olga
Mei, Xiaohu

PMID: 24038317; PMCID: PMC3826673; DOI: 10.1194/jlr.R037911;

Meyers NL, Wang L, Gursky O, Small DM. Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces. J Lipid Res. 2013 Jul; 54(7):1927-38.View Related Profiles.

Small, Donald
Meyers, Nathan
Gursky, Olga

PMID: 23670531; PMCID: PMC3679394; DOI: 10.1194/jlr.M037531;

Gursky O. Crystal structure of ?(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil. J Mol Biol. 2013 Jan 9; 425(1):1-16. PMID: 23041415; PMCID: PMC3534807; DOI: 10.1016/j.jmb.2012.09.027;

Lu M, Gantz DL, Herscovitz H, Gursky O. Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis. J Lipid Res. 2012 Oct; 53(10):2175-85.View Related Profiles.

Herscovitz, Haya
Lu, Mengxiao
Gursky, Olga

PMID: 22855737; PMCID: PMC3435550; DOI: 10.1194/jlr.M029629;

Gao X, Yuan S, Jayaraman S, Gursky O. Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL. Biochemistry. 2012 Jun 12; 51(23):4633-41.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Yuan, Shujun
Gao, Xuan

PMID: 22631438; PMCID: PMC5603225; DOI: 10.1021/bi300555d;

Jayaraman S, Cavigiolio G, Gursky O. Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis. Biochem J. 2012 Mar 15; 442(3):703-12.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 22150513; PMCID: PMC3857142; DOI: 10.1042/BJ20111831;

Gao X, Jayaraman S, Guha M, Wally J, Lu M., Atkinson D, Gursky O. . Circular Dichroism: Theory and Spectroscopy, D.S. Rogers, Edt. Nova Publishers pp. 175-215. Application of Circular Dichroism to Lipoproteins: Structure, Stability and Remodeling of Good and Bad Cholesterol. Chapter 4. 2012.

Gursky O, Mei X, Atkinson D. The crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment. Biochemistry. 2012 Jan 10; 51(1):10-8.View Related Profiles.

Atkinson, David
Gursky, Olga
Mei, Xiaohu

PMID: 22229410; PMCID: PMC4442606; DOI: 10.1021/bi2017014;

Guha M, Gursky O. Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH. J Lipids. 2011; 2011:493720. PMID: 21773050; PMCID: PMC3136112; DOI: 10.1155/2011/493720;

Jayaraman S, Jasuja R, Zakharov MN, Gursky O. Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface. Biochemistry. 2011 May 17; 50(19):3919-27.View Related Profiles.

Zakharov, Mikhail
Gursky, Olga
Jasuja, Ravi
Jayaraman, Shobini

PMID: 21452855; PMCID: PMC5601316; DOI: 10.1021/bi200090y;

Jayaraman S, Gantz DL, Gursky O. Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets. J Lipid Res. 2011 Mar; 52(3):549-57.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 21220788; PMCID: PMC3035691; DOI: 10.1194/jlr.M012567;

Guha M, Gursky O. Effects of oxidation on structural stability and remodeling of human very low density lipoprotein. Biochemistry. 2010 Nov 9; 49(44):9584-93. PMID: 20919745; PMCID: PMC5601319; DOI: 10.1021/bi101391z;

Klimtchuk ES, Gursky O, Patel RS, Laporte KL, Connors LH, Skinner M, Seldin DC. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain. Biochemistry. 2010 Nov 16; 49(45):9848-57.View Related Profiles.

Seldin, David
Klimtchuk, Elena
Connors, Lawreen
Skinner, Martha
Gursky, Olga

PMID: 20936823; PMCID: PMC4080313; DOI: 10.1021/bi101351c;

Benjwal S, Gursky O. Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins. Proteins. 2010 Apr; 78(5):1175-85. PMID: 19927327; PMCID: PMC2822151; DOI: 10.1002/prot.22637;

Jayaraman S, Benjwal S, Gantz DL, Gursky O. Effects of cholesterol on thermal stability of discoidal high density lipoproteins. J Lipid Res. 2010 Feb; 51(2):324-33.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 19700415; PMCID: PMC2803234; DOI: 10.1194/jlr.M000117;

Gao X, Yuan S, Jayaraman S, Gursky O. Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition. J Mol Biol. 2009 Apr 3; 387(3):628-38.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Yuan, Shujun
Gao, Xuan

PMID: 19236880; PMCID: PMC2706704; DOI: 10.1016/j.jmb.2009.02.036;

Guha M, Gao X, Jayaraman S, Gursky O. Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered. Biochemistry. 2008 Nov 4; 47(44):11393-7.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Gao, Xuan

PMID: 18839964; PMCID: PMC2822716; DOI: 10.1021/bi8014746;

Guha M, Gantz DL, Gursky O. Effects of acyl chain length, unsaturation, and pH on thermal stability of model discoidal HDLs. J Lipid Res. 2008 Aug; 49(8):1752-61. PMID: 18456639; PMCID: PMC2444001; DOI: 10.1194/jlr.M800106-JLR200;

Jayaraman S, Gantz DL, Gursky O. Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins. Biochemistry. 2008 Mar 25; 47(12):3875-82.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 18302337; PMCID: PMC2823073; DOI: 10.1021/bi7023783;

Gao X, Jayaraman S, Gursky O. Mild oxidation promotes and advanced oxidation impairs remodeling of human high-density lipoprotein in vitro. J Mol Biol. 2008 Feb 29; 376(4):997-1007.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Gao, Xuan

PMID: 18190928; PMCID: PMC2276461; DOI: 10.1016/j.jmb.2007.12.030;

Guha M, England C, Herscovitz H, Gursky O. Thermal transitions in human very-low-density lipoprotein: fusion, rupture, and dissociation of HDL-like particles. Biochemistry. 2007 May 22; 46(20):6043-9.View Related Profiles.

Herscovitz, Haya
Gursky, Olga

PMID: 17469851; PMCID: PMC2577769; DOI: 10.1021/bi7001532;

Jayaraman S, Gantz DL, Gursky O. Effects of oxidation on the structure and stability of human low-density lipoprotein. Biochemistry. 2007 May 15; 46(19):5790-7.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 17444660

Benjwal S, Jayaraman S, Gursky O. Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes. Biochemistry. 2007 Apr 3; 46(13):4184-94.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 17341095; PMCID: PMC2584444; DOI: 10.1021/bi062175c;

Gursky O. Does alpha-helix folding necessarily provide an energy source for the protein-lipid binding? Protein Pept Lett. 2007; 14(2):171-4. PMID: 17305604

Jayaraman S, Gantz DL, Gursky O. Effects of salt on the thermal stability of human plasma high-density lipoprotein. Biochemistry. 2006 Apr 11; 45(14):4620-8.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 16584197

Benjwal S, Verma S, Röhm KH, Gursky O. Monitoring protein aggregation during thermal unfolding in circular dichroism experiments. Protein Sci. 2006 Mar; 15(3):635-9. PMID: 16452626; PMCID: PMC2249783; DOI: 10.1110/ps.051917406;

Benjwal S, Jayaraman S, Gursky O. Electrostatic effects on the stability of discoidal high-density lipoproteins. Biochemistry. 2005 Aug 2; 44(30):10218-26.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 16042399

Gursky O. Apolipoprotein structure and dynamics. Curr Opin Lipidol. 2005 Jun; 16(3):287-94. PMID: 15891389

Chung CM, Chiu JD, Connors LH, Gursky O, Lim A, Dykstra AB, Liepnieks J, Benson MD, Costello CE, Skinner M, Walsh MT. Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma. Biophys J. 2005 Jun; 88(6):4232-42.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Gursky, Olga

PMID: 15792972; PMCID: PMC1305653; DOI: 10.1529/biophysj.105.061317;

Jayaraman S, Gantz D, Gursky O. Structural basis for thermal stability of human low-density lipoprotein. Biochemistry. 2005 Mar 15; 44(10):3965-71.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 15751972

Jayaraman S, Gantz DL, Gursky O. Kinetic stabilization and fusion of apolipoprotein A-2:DMPC disks: comparison with apoA-1 and apoC-1. Biophys J. 2005 Apr; 88(4):2907-18.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 15681655; PMCID: PMC1305385; DOI: 10.1529/biophysj.104.055921;

Jayaraman S, Gantz DL, Gursky O. Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins. Biochemistry. 2004 May 11; 43(18):5520-31.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 15122918

Fang Y, Gursky O, Atkinson D. Lipid-binding studies of human apolipoprotein A-I and its terminally truncated mutants. Biochemistry. 2003 Nov 18; 42(45):13260-8.View Related Profiles.

Atkinson, David
Gursky, Olga

PMID: 14609337

Fang Y, Gursky O, Atkinson D. Structural studies of N- and C-terminally truncated human apolipoprotein A-I. Biochemistry. 2003 Jun 10; 42(22):6881-90.View Related Profiles.

Atkinson, David
Gursky, Olga

PMID: 12779343

Mehta R, Gantz DL, Gursky O. Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins. Biochemistry. 2003 Apr 29; 42(16):4751-8. PMID: 12705839

Mehta R, Gantz DL, Gursky O. Human plasma high-density lipoproteins are stabilized by kinetic factors. J Mol Biol. 2003 Apr 18; 328(1):183-92. PMID: 12684007

Gursky O, Ranjana, Gantz DL. Complex of human apolipoprotein C-1 with phospholipid: thermodynamic or kinetic stability? Biochemistry. 2002 Jun 11; 41(23):7373-84. PMID: 12044170

Gursky, O. Energetic-structure-function of lipoproteins and their protein components. In: Recent research developments in proteins, S.G. Pandalai, edt., Transworld Res. Network, Vol. 1, pp. 97-121. 2002.

Gursky O. Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: far- and near-UV CD study. Biochemistry. 2001 Oct 9; 40(40):12178-85. PMID: 11580293

Gorshkova IN, Liadaki K, Gursky O, Atkinson D, Zannis VI. Probing the lipid-free structure and stability of apolipoprotein A-I by mutation. Biochemistry. 2000 Dec 26; 39(51):15910-9.View Related Profiles.

Atkinson, David
Gorshkova, Irina
Gursky, Olga
Zannis, Vassilis

PMID: 11123918

Gursky O, Aleshkov S. Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation. Biochim Biophys Acta. 2000 Jan 3; 1476(1):93-102. PMID: 10606771

Gursky O. Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide. Protein Sci. 1999 Oct; 8(10):2055-64. PMID: 10548051; PMCID: PMC2144123

Gursky O, Atkinson D. Thermodynamic analysis of human plasma apolipoprotein C-1: high-temperature unfolding and low-temperature oligomer dissociation. Biochemistry. 1998 Feb 3; 37(5):1283-91.View Related Profiles.

Atkinson, David
Gursky, Olga

PMID: 9477954

Gursky O, Atkinson D. High- and low-temperature unfolding of human high-density apolipoprotein A-2. Protein Sci. 1996 Sep; 5(9):1874-82.View Related Profiles.

Atkinson, David
Gursky, Olga

PMID: 8880911; PMCID: PMC2143548

Gursky O, Atkinson D. Thermal unfolding of human high-density apolipoprotein A-1: implications for a lipid-free molten globular state. Proc Natl Acad Sci U S A. 1996 Apr 2; 93(7):2991-5.View Related Profiles.

Atkinson, David
Gursky, Olga

PMID: 8610156; PMCID: PMC39748

Gursky O, Fontano E, Bhyravbhatla B, Caspar DL. Stereospecific dihaloalkane binding in a pH-sensitive cavity in cubic insulin crystals. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12388-92. PMID: 7809046; PMCID: PMC45443

Badger J, Kapulsky A, Gursky O, Bhyravbhatla B, Caspar DL. Structure and selectivity of a monovalent cation binding site in cubic insulin crystals. Biophys J. 1994 Feb; 66(2 Pt 1):286-92. PMID: 8161680; PMCID: PMC1275693

Badger J., Gursky O., Caspar D.L. D. . Electrostatic interactions and conformational variability in cubic insulin crystals. In: Synchrotron radiation in the Biosciences, B. Chance et al., edt. Clarendon Press,. 1994; pp. 43-51..

Gursky O, Badger J, Li Y, Caspar DL. Conformational changes in cubic insulin crystals in the pH range 7-11. Biophys J. 1992 Nov; 63(5):1210-20. PMID: 1477273; PMCID: PMC1261424

Gursky O, Li Y, Badger J, Caspar DL. Monovalent cation binding to cubic insulin crystals. Biophys J. 1992 Mar; 61(3):604-11. PMID: 1504238; PMCID: PMC1260278

Gursky O. X-ray crystallographic studies of electrostatic effects in cubic insulin. PhD Thesis. Waltham. 1992.
Lvov Yu. M., Gurskaja O. B., Berzina T. S., Troitsky V. I. . Structure of Langmuir-Blodgett superlattices with alternative bilayers of barium behenate, phtalocyanine, and octadecyl ethylene phenol. Thin Solid Films. 1989; 182:283-296.
Lvov Yu. M., Gurskaya O. B. . Investigation of Langmuir-Blodgett films by the methods of X-ray small-angle diffractometry and reflectometry. Sov. Phys. Crystallography. 1989; 5 (34):749-752 .

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 98 publications over 31 distinct years, with a maximum of 8 publications in 2023

Bar chart showing 98 publications over 31 distinct years, with a maximum of 8 publications in 2023

Year	Publications
1989	2
1992	3
1994	3
1996	2
1998	1
1999	1
2000	2
2001	1
2002	2
2003	4
2004	1
2005	5
2006	2
2007	5
2008	3
2009	2
2010	3
2011	4
2012	5
2013	3
2014	2
2015	6
2016	6
2017	5
2018	4
2019	2
2020	4
2021	4
2022	1
2023	8
2024	2

Media Mentions

Researchers suggest that amyloid contributes to calcific aortic valve disease development

Medical Xpress 6/5/2024

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Protein-lipid interactions
Protein misfolding and amyloid diseases
lipoproteins
protein spectroscopy
protein stability
protein structure-function
thermodynamics and kinetics
structural biology and spectroscopy

I have the expertise to mentor pre- and post-doctoral trainees in fundamental research and its application to cardiovascular, metabolic and amyloid diseases. Our laboratory is fully committed to attracting and retaining women and minorities in science, includes two T32-supported members who are URM, and is known for its supportive family-friendly atmosphere. Our trainees master quantitative biophysical, biochemical and structural biology techniques. They benefit from our local, national and international collaborations in cell, molecular and structural biology, including cutting-edge methods in mass spectrometry, computational biology, and clinical studies. These collaborations greatly enrich the training experience. All trainees are active in teaching at the undergraduate or graduate levels, and are actively obtaining funding for research and conference travel. Our past trainees have received multiple Young Investigator Awards from the Protein Society, Gordon conferences and other venues. All our trainees have multiple publications in peer-reviewed journals. All trainees have moved on to their own successful careers in life sciences, including industry, academia, consulting and venture capital.

My commitment to graduate students’ mentoring is evident from my service for nearly 20 years on the Students Admissions and Affairs Committee in the Department; 5 years on MD/PhD admissions committee at the Boston University School of Medicine; 15 years on Students Achievement Day committee. I also serve on the Admissions Committee for the Program in Biological Sciences (PiBS), an umbrella program in Graduate Medical Sciences at the School of Medicine. I have years of service as a facilitator of the NIH-mandated Responsible Conduct of Research training; on students’ ethics violations committees; on approximately 50 PhD thesis defense committees, and on PhD qualifying exams for over 50 students. For years, I have been teaching three graduate-level courses at the department and the school.

Available to Mentor as: (Review Mentor Role Definitions):