Olga Gursky, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Brandeis University
MS, Moscow State University




Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis.

Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability.

A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Apolipoprotein conformation in amyloid and cardiovascular diseases
09/15/2017 - 08/31/2021 (PI)
NIH/National Institute of General Medical Sciences
5R01GM067260-16

Structural Stability and Functional Remodeling of High-density Lipoproteins
07/01/2016 - 09/14/2017 (PI)
NIH/National Institute of General Medical Sciences
4R01GM067260-14

Structural Stability and Functional Remodeling of High-density Lipoproteins
09/01/2013 - 06/30/2016 (PI)
NIH/National Institute of General Medical Sciences
3R01GM067260-13S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/20/2002 - 05/31/2008 (PI)
NIH/National Institute of General Medical Sciences
3 R01 GM67260 08S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/15/1998 - 11/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R29 HL61429 04




Yr Title Project-Sub Proj Pubs
2018 Apolipoprotein conformation in amyloid and cardiovascular diseases 5R01GM067260-16 53
2017 Apolipoprotein conformation in amyloid and cardiovascular diseases 2R01GM067260-15 53
2016 Structural stability and functional remodeling of high-density lipoproteins 4R01GM067260-14 53
2015 Structural stability and functional remodeling of high-density lipoproteins 5R01GM067260-13 53
2015 Structural stability and functional remodeling of high-density lipoproteins 3R01GM067260-13S1 53
2014 Structural stability and functional remodeling of high-density lipoproteins 5R01GM067260-12 53
2013 Structural stability and functional remodeling of high-density lipoproteins 2R01GM067260-11A1 53
2010 Structural stability and fusion of high- and very-low-density lipoproteins contai 5R01GM067260-10 53
2010 Energetics-Structure-Function Relationship in Lipoproteins 5P01HL026335-30-9 235
2009 Structural stability and fusion of high- and very-low-density lipoproteins contai 2R01GM067260-09A1 53
Showing 10 of 22 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jayaraman S, Fändrich M, Gursky O. Synergy between serum amyloid A and secretory phospholipase A2. Elife. 2019 May 21; 8.View Related Profiles. PMID: 31111824.
     
  2. Jayaraman S, Baveghems C, Chavez OR, Rivas-Urbina A, Sánchez-Quesada JL, Gursky O. Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul; 1864(7):1061-1071.View Related Profiles. PMID: 30844432.
     
  3. Morgado I, Panahi A, Burwash AG, Das M, Straub JE, Gursky O. Molecular Insights into Human Hereditary Apolipoprotein A-I Amyloidosis Caused by the Glu34Lys Mutation. Biochemistry. 2018 Oct 02; 57(39):5738-5747.View Related Profiles. PMID: 30184436.
     
  4. Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR. Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry. 2018 07 31; 57(30):4583-4596.View Related Profiles. PMID: 30004693.
     
  5. Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6428-E6436.View Related Profiles. PMID: 29941560.
     
  6. Jayaraman S, Gantz DL, Haupt C, Fändrich M, Gursky O. Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner. Chem Commun (Camb). 2018 Apr 03; 54(28):3532-3535.View Related Profiles. PMID: 29565436.
     
  7. Madico G, Gursky O, Fairman J, Massari P. Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens. Vaccines (Basel). 2017 Dec 25; 6(1).View Related Profiles. PMID: 29295593.
     
  8. Prokaeva T, Akar H, Spencer B, Havasi A, Cui H, O'Hara CJ, Gursky O, Leszyk J, Steffen M, Browning S, Rosenberg A, Connors LH. Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant. Kidney Int Rep. 2017 Nov; 2(6):1223-1232.View Related Profiles. PMID: 29270531.
     
  9. Jayaraman S, Gantz DL, Haupt C, Gursky O. Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6507-E6515.View Related Profiles. PMID: 28743750.
     
  10. Frame NM, Jayaraman S, Gantz DL, Gursky O. Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response. J Struct Biol. 2017 Dec; 200(3):293-302.View Related Profiles. PMID: 28645735.
     
Showing 10 of 72 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 25 distinct years, with a maximum of 6 publications in 2016

YearPublications
19922
19942
19962
19981
19991
20002
20011
20021
20034
20041
20055
20062
20075
20083
20092
20103
20114
20124
20133
20142
20155
20166
20175
20184
20192
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

calorimetry
energy landscapes
lipoproteins
protein spectroscopy
protein stability
protein structure-function
thermodynamics and kinetics

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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