Michael Rynkiewicz
Instructor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Boston University School of Medicine



I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.


Structural Analysis of Anticancer Compound Targets on Tpm3.1 Tropomyosin
04/01/2016 - 06/30/2017 (Co-PI)
PI: William J. Lehman, PhD
Novogen





Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 Jul 06; 293(27):10646-10662.View Related Profiles. PMID: 29769321.
     
  2. Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked a-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018 Jun 01; 647:84-92.View Related Profiles. PMID: 29626422.
     
  3. Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J. 2017 Dec 05; 113(11):2444-2451.View Related Profiles. PMID: 29211998.
     
  4. Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Rep. 2017 Sep 12; 20(11):2612-2625.View Related Profiles. PMID: 28903042.
     
  5. Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. 2017 Aug 08; 56(31):4095-4105.View Related Profiles. PMID: 28719181.
     
  6. Rynkiewicz MJ, Fischer S, Lehman W. The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys. 2016 Nov 01; 609:51-58.View Related Profiles. PMID: 27663225; DOI: 10.1016/j.abb.2016.09.008;.
     
  7. Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 05; 55(26):3692-701.View Related Profiles. PMID: 27324153; DOI: 10.1021/acs.biochem.6b00048;.
     
  8. Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan; 3(1):012002.View Related Profiles. PMID: 26798831; DOI: 10.1063/1.4940223;.
     
  9. Tripathi S, Wang G, White M, Rynkiewicz M, Seaton B, Hartshorn K. Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. PLoS One. 2015; 10(8):e0133454.View Related Profiles. PMID: 26308522; PMCID: PMC4550355; DOI: 10.1371/journal.pone.0133454;.
     
  10. Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. J Muscle Res Cell Motil. 2015 Dec; 36(6):525-33.View Related Profiles. PMID: 26286845; PMCID: PMC4760918; DOI: 10.1007/s10974-015-9419-z;.
     
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 16 distinct years, with a maximum of 3 publications in 2006 and 2014 and 2016 and 2017

YearPublications
19961
20001
20011
20021
20041
20051
20063
20102
20112
20122
20132
20143
20152
20163
20173
20182
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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