Michael Rynkiewicz, PhD
Instructor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Boston University School of Medicine
BS, Massachusetts Institute of Technology



I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.


Structural Analysis of Anticancer Compound Targets on Tpm3.1 Tropomyosin
04/01/2016 - 06/30/2017 (Co-Investigator)
PI: William J. Lehman, PhD
Novogen




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Rynkiewicz MJ, Childers MC, Karpicheva OE, Regnier M, Geeves MA, Lehman W. Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. J Gen Physiol. 2024 May 06; 156(5). PMID: 38607351; PMCID: PMC11010328; DOI: 10.1085/jgp.202413538;
     
  2. Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. J Mol Cell Cardiol. 2024 Mar; 188:30-37.View Related Profiles. PMID: 38266978
     
  3. Lewkowicz E, Nakamura MN, Rynkiewicz MJ, Gursky O. Molecular modeling of apoE in complexes with Alzheimer's amyloid-ß fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cell Mol Life Sci. 2023 Nov 27; 80(12):376.View Related Profiles. PMID: 38010414; PMCID: PMC11061799; DOI: 10.1007/s00018-023-05026-w;
     
  4. Lewkowicz E, Nakamura MN, Rynkiewicz MJ, Gursky O. Molecular modeling of apoE in complexes with Alzheimer's amyloid-ß fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. bioRxiv. 2023 Aug 06.View Related Profiles. PMID: 37577501; PMCID: PMC10418262; DOI: 10.1101/2023.08.04.551703;
     
  5. Lehman W, Rynkiewicz MJ. Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. J Gen Physiol. 2023 Jul 03; 155(7). PMID: 37249525; PMCID: PMC10227645; DOI: 10.1085/jgp.202313387;
     
  6. Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. PNAS Nexus. 2023 Mar; 2(3):pgad011.View Related Profiles. PMID: 36896133; PMCID: PMC9991458; DOI: 10.1093/pnasnexus/pgad011;
     
  7. Doran MH, Rynkiewicz MJ, Rassici D, Bodt SML, Barry ME, Bullitt E, Yengo CM, Moore JR, Lehman W. Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J Gen Physiol. 2023 Mar 06; 155(3).View Related Profiles. PMID: 36633586; PMCID: PMC9859928; DOI: 10.1085/jgp.202213267;
     
  8. Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci D, Moore JR, Yengo CM, Bullitt E, Lehman W. Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J Gen Physiol. 2023 Feb 06; 155(2).View Related Profiles. PMID: 36459134; PMCID: PMC9723511; DOI: 10.1085/jgp.202213274;
     
  9. Rynkiewicz MJ, Pavadai E, Lehman W. Modeling Human Cardiac Thin Filament Structures. Front Physiol. 2022; 13:932333.View Related Profiles. PMID: 35812320; PMCID: PMC9257132; DOI: 10.3389/fphys.2022.932333;
     
  10. Pavadai E, Rynkiewicz MJ, Yang Z, Gould IR, Marston SB, Lehman W. Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation. Arch Biochem Biophys. 2022 Aug 15; 725:109282.View Related Profiles. PMID: 35577070; PMCID: PMC10680062; DOI: 10.1016/j.abb.2022.109282;
     
Showing 10 of 57 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 57 publications over 22 distinct years, with a maximum of 7 publications in 2019

YearPublications
19961
20001
20011
20021
20041
20051
20063
20102
20112
20122
20132
20143
20152
20163
20173
20184
20197
20205
20212
20224
20235
20242

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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