Maria Isabel Ramirez, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

PhD, University of Buenos Aires
PhD, Universidad de Buenos Aires

The main goal of the research in our lab is to identify and understand genetic and epigenetic mechanisms of gene regulation driving the differentiation of distinct epithelial cell lineages during development, and the potential alteration of these mechanisms in lung disease. Correct spatial and temporal patterns of gene expression during lung development are critical for the formation of a functional lung ready for the first breath at birth. In adults, patterns of gene expression also have to be maintained to preserve a healthy lung. Dissecting these basic mechanisms in development will provide the basis to accurately differentiate embryonic stem cells into lung epithelial cell lineages in vitro, to improve fetal lung maturation and to understand altered cell phenotypes in lung disease.

Boston University
BU-BMC Cancer Center

Boston University
Center for Regenerative Medicine

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

1998-2001 Boston University School of Medicine: Parker B. Francis Foundation, Lung Research Fellowship
1997 Boston University School of Medicine: Evans Research Days Poster Award 1st Place
1994-1996 University of Massachusetts Medical Center: American Heart Association, Massachusetts Affiliate Postdoctoral Fellowship (Declined)
1994 Universidad de Buenos Aires, Argentina: Fundacion de Ciencias Exactas y Naturales, Thesis Dissertation Award
1992 Universidad de Buenos Aires, Argentina: Argentine Chemical Association, Dr. Herrero-Ducloux Biannual Doctoral Thesis Award
1988-1991 Universidad de Buenos Aires, Argentina: National Council of Science (CONICET), Argentina. Pre-Doctoral Fellowship

Summer Research and Educational Program
02/01/2016 - 04/30/2018 (PI of Sub-Project / SP)
PI: Linda E. Hyman, PhD
NIH/National Heart, Lung, and Blood Institute

Molecular and biological function of long non-coding RNA transcripts divergent to lung developmental genes
09/01/2015 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute

Summer Research and Educational Program
08/20/2013 - 01/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute

Regulation and Function of the Alveolar Type I Cell T1 (Type II) Gene in Genetically Altered Mice
07/01/1998 - 06/30/2001 (PI)
Parker B. Francis Foundation


Yr Title Project-Sub Proj Pubs
2021 Lung epithelial lineage-specific factors in the control of immune system evasion genes in tumor cells 1R03CA252779-01A1
2018 Molecular and biological function of long non-coding RNA transcripts divergent to lung development genes 5R01HL127426-04
2018 STaRS at BU - Summer Training as Research Scholars at Boston University 2R25HL118693-06
2017 Molecular and biological function of long non-coding RNA transcripts divergent to lung development genes 7R01HL127426-03
2016 Molecular and biological function of long non-coding RNA transcripts divergent to lung developmental genes 5R01HL127426-02
2016 Summer Research and Educational Program 4R25HL118693-04
2015 Molecular and biological function of long non-coding RNA transcripts divergent to lung developmental genes 1R01HL127426-01
2015 Summer Research and Educational Program 5R25HL118693-03
2012 Chromatin Modifications and DNA Methylation During Early Lung Development 5P01HL047049-20-5545 92
2012 Mouse Genetics 5P01HL047049-20-5548 92
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kathuria H, Millien G, McNally L, Gower AC, Tagne JB, Cao Y, Ramirez MI. NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration. Sci Rep. 2018 09 26; 8(1):14418.View Related Profiles. PMID: 30258080; PMCID: PMC6158174; DOI: 10.1038/s41598-018-32793-5;
  2. Millien G, Cao Y, O'Hara CJ, Tagne JB, Hinds A, Williams MC, Ramirez MI, Kathuria H. ETS1 regulates Twist1 transcription in a KrasG12D/Lkb1-/- metastatic lung tumor model of non-small cell lung cancer. Clin Exp Metastasis. 2018 03; 35(3):149-165.View Related Profiles. PMID: 29909489
  3. Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18.View Related Profiles. PMID: 27064756; PMCID: PMC5023025; DOI: 10.1165/rcmb.2015-0261OC;
  4. Krishnan H, Retzbach EP, Ramirez MI, Liu T, Li H, Miller WT, Goldberg GS. PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility. Exp Cell Res. 2015 Jul 1; 335(1):115-22. PMID: 25959509; PMCID: PMC4556139; DOI: 10.1016/j.yexcr.2015.04.019;
  5. Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles. PMID: 25843048; PMCID: PMC4437473; DOI: 10.1016/j.stemcr.2015.02.021;
  6. Tagne JB, Mohtar OR, Campbell JD, Lakshminarayanan M, Huang J, Hinds AC, Lu J, Ramirez MI. Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb. Respir Res. 2015; 16:22.View Related Profiles. PMID: 25763778; PMCID: PMC4335692; DOI: 10.1186/s12931-015-0186-6;
  7. Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D. Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1; 306(5):L405-19. PMID: 24375798; PMCID: PMC3949053; DOI: 10.1152/ajplung.00143.2013;
  8. Krishnan H, Ochoa-Alvarez JA, Shen Y, Nevel E, Lakshminarayanan M, Williams MC, Ramirez MI, Miller WT, Goldberg GS. Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. J Biol Chem. 2013 Apr 26; 288(17):12215-21. PMID: 23530051; PMCID: PMC3636905; DOI: 10.1074/jbc.C112.446823;
  9. Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI. The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012 Oct 26; 287(44):37282-95.View Related Profiles. PMID: 22955271; PMCID: PMC3481326; DOI: 10.1074/jbc.M112.408401;
  10. Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol. 2012 Sep 1; 189(5):2450-9.View Related Profiles. PMID: 22844121; PMCID: PMC3424336; DOI: 10.4049/jimmunol.1200634;
Showing 10 of 38 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 38 publications over 22 distinct years, with a maximum of 4 publications in 2003 and 2007 and 2009 and 2012


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Chromatin remodeling
Gene regulation
Lung development
Lung epithelium
Mouse models
Non-coding RNA

Available to Mentor as: (Review Mentor Role Definitions):
  • Diversity Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

75 E. Newton St Evans Building
Boston MA 02118
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