Lauren Brown

Research Associate Professor

Boston University College of Arts and Sciences

Chemistry

PhD, University of California, Santa Cruz
BS, University of Southern California

Websites

Research Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

BU Research

Targeting Hsp90 in cryptococcal fungal pathogenesis
07/21/2022 - 06/30/2027 (Subcontract PI)
Governing Council of the University of Toronto NIH NIAID
5R01AI165466-03

Targeting the Genus Leishmania with Small Molecules
03/24/2021 - 02/28/2026 (Multi-PI)
PI: Lauren Brown
NIH/National Institute of Allergy & Infectious Diseases
5R01AI151639-04

Accelerating General Anesthetic Discovery and Mechanisms Research with Zebrafish
08/01/2018 - 07/31/2021 (Subcontract PI)
Massachusetts General Hospital NIH NIGMS
5R01GM128989-03

Targeting Hsp90 in cryptococcal fungal pathogenesis
06/15/2016 - 05/31/2021 (Subcontract PI)
Governing Council of the University of Toronto NIH NIAID
5R01AI20958-04

Elucidating the T Brachyury pathway in Chordoma Using a Chemical Biology Approach
07/01/2017 - 03/31/2018 (Co-Investigator)
The Brigham and Women's Hospital, Inc. Chordoma Foundation

New Compounds for the Treatment of Leishmaniasis
12/30/2013 - 03/01/2017 (Co-Investigator)
PI: Scott Schaus, PhD
GlaxoSmithKline Investigacion y Desarrollo, S.L.

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Goldstein SI, Fan AC, Wang Z, Naineni SK, Cencic R, Garcia-Gutierrez SB, Patel K, Huang S, Brown LE, Emili A, Porco JA. Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays. J Proteome Res. 2025 Apr 04; 24(4):2026-2039.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 40077831

Conley JF, Brown LE, McNeely JH, Pelletier J, Porco JA, Allen KN. Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1. ACS Omega. 2025 Feb 18; 10(6):5795-5808.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 39989799; PMCID: PMC11840593; DOI: 10.1021/acsomega.4c09421;

Oo A, Borge A, Lee RCH, Salim CK, Wang W, Ricca M, Fong DY, Alonso S, Brown LE, Porco JA, Chu JJH. In Vitro Discovery of a Therapeutic Lead for HFMD From a Library Screen of Rocaglates/Aglains. J Med Virol. 2025 Feb; 97(2):e70228.View Related Profiles.

Porco, John
Brown, Lauren
Ricca, Michael

PMID: 39921602; PMCID: PMC11806654; DOI: 10.1002/jmv.70228;

Avancha A, Hoyt H, Bhave K, Medeiros M, Cho D, Brown LE, Fernández González D, Porco JA, Forman SA. Glabridin Hypnosis in Zebrafish Larvae Is Associated With Effects on Multiple Anesthetic Target Receptors. Anesth Analg. 2024 Nov 21.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 39773742

Wang Z, Thakare RP, Chitale S, Mishra AK, Goldstein SI, Fan AC, Li R, Zhu LJ, Brown LE, Cencic R, Huang S, Green MR, Pelletier J, Malonia SK, Porco JA. Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS Cent Sci. 2024 Aug 28; 10(8):1640-1656.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 39220711; PMCID: PMC11363328; DOI: 10.1021/acscentsci.4c01073;

Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA. Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Res. 2024 Oct; 230:105976.View Related Profiles.

Wacquiez, Alan Cyril Jacques
Porco, John
Connor, John
Brown, Lauren
Ricca, Michael
Saeed, Mohsan
Davey, Robert
Lyons, Shawn

PMID: 39117283; PMCID: PMC11434215; DOI: 10.1016/j.antiviral.2024.105976;

Thirman HL, Hayes MJ, Brown LE, Porco JA, Irish JM. Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv. 2024 May 03.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 38826485; PMCID: PMC11142275; DOI: 10.1101/2024.05.01.591362;

Volegova MP, Brown LE, Banerjee U, Dries R, Sharma B, Kennedy A, Porco JA, George RE. The MYCN 5' UTR as a therapeutic target in neuroblastoma. Cell Rep. 2024 May 28; 43(5):114134.View Related Profiles.

Porco, John
Brown, Lauren
Dries, Ruben

PMID: 38662542; PMCID: PMC11284644; DOI: 10.1016/j.celrep.2024.114134;

Goldstein SI, Fan AC, Wang Z, Naineni SK, Lengqvist J, Chernobrovkin A, Garcia-Gutierrez SB, Cencic R, Patel K, Huang S, Brown LE, Emili A, Porco JA. Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR). bioRxiv. 2024 Apr 19.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 38659867; PMCID: PMC11042367; DOI: 10.1101/2024.04.19.590252;

Fallah S, Duncan D, Reichl KD, Smith MJ, Wang W, Porco JA, Brown LE, Whitesell L, Robbins N, Cowen LE. A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans. Microbiol Spectr. 2024 Apr 02; 12(4):e0409523.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 38376363; PMCID: PMC10986608; DOI: 10.1128/spectrum.04095-23;

Showing 10 of 53 results. Show More

Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. J Org Chem. 2023 Sep 15; 88(18):13135-13141.View Related Profiles.

Beeler, Aaron
Porco, John
Brown, Lauren

PMID: 37657122; PMCID: PMC10696561; DOI: 10.1021/acs.joc.3c01362;

Naineni SK, Cencic R, Robert F, Brown LE, Haque M, Scott-Talib J, Sénéchal P, Schmeing TM, Porco JA, Pelletier J. Exploring the targeting spectrum of rocaglates among eIF4A homologs. RNA. 2023 Jun; 29(6):826-835.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 36882295; PMCID: PMC10187672; DOI: 10.1261/rna.079318.122;

Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection. Front Trop Dis. 2023; 3.View Related Profiles.

Brown, Lauren
Schaus, Scott

PMID: 36818551; PMCID: PMC9937549; DOI: 10.3389/fitd.2022.1011124;

Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, Lecomte N, Mayer S, Stok R, Bishara H, Hamodi R, Levy-Lahad E, Golan T, Porco JA, Iacobuzio-Donahue CA, Schultz N, Tuveson DA, Lyden D, Kelsen D, Scherz-Shouval R. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nat Commun. 2022 Oct 31; 13(1):6513.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 36316305; PMCID: PMC9622893; DOI: 10.1038/s41467-022-34081-3;

Brown LE, Seitz S, Kondas AV, Marcyk PT, Filone CM, Hossain MM, Schaus SE, Olson VA, Connor JH. Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. Antimicrob Agents Chemother. 2022 Nov 15; 66(11):e0084122.View Related Profiles.

Filone, Claire Marie
Connor, John
Brown, Lauren
Schaus, Scott
Seitz, Scott

PMID: 36222522; PMCID: PMC9664851; DOI: 10.1128/aac.00841-22;

Lehman SL, Wechsler T, Schwartz K, Brown LE, Porco JA, Devine WG, Pelletier J, Shankavaram UT, Camphausen K, Tofilon PJ. Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity. Mol Cancer Ther. 2022 Sep 06; 21(9):1406-1414.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 35732578; PMCID: PMC9452469; DOI: 10.1158/1535-7163.MCT-22-0037;

Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Res. 2022 Aug; 204:105359.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 35728703; PMCID: PMC9731315; DOI: 10.1016/j.antiviral.2022.105359;

Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. J Org Chem. 2021 12 03; 86(23):16485-16510.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 34730970; PMCID: PMC8783553; DOI: 10.1021/acs.joc.1c01848;

Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis. iScience. 2021 Aug 20; 24(8):102845.View Related Profiles.

Beeler, Aaron
Bhattacharya, Bidisha
Kramnik, Igor
Porco, John
Brown, Lauren
Yabaji, Shivraj

PMID: 34381970; PMCID: PMC8333345; DOI: 10.1016/j.isci.2021.102845;

Viarengo-Baker LA, Brown LE, Rzepiela AA, Whitty A. Defining and navigating macrocycle chemical space. Chem Sci. 2021 Mar 04; 12(12):4309-4328.View Related Profiles.

Whitty, Adrian
Brown, Lauren

PMID: 34163695; PMCID: PMC8179434; DOI: 10.1039/d0sc05788f;

Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, Brown LE. Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. J Med Chem. 2021 01 28; 64(2):1139-1169. PMID: 33444025; PMCID: PMC8493596; DOI: 10.1021/acs.jmedchem.0c01777;

Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nat Commun. 2020 12 22; 11(1):6429.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 33353950; PMCID: PMC7755909; DOI: 10.1038/s41467-020-20183-3;

Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, Porco JA, Sahai E, Shouval DS, Kelsen D, Scherz-Shouval R. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nat Commun. 2020 12 07; 11(1):6245.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 33288768; PMCID: PMC7721883; DOI: 10.1038/s41467-020-20054-x;

Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. mBio. 2020 03 10; 11(2).View Related Profiles.

Porco, John
Brown, Lauren

PMID: 32156828; PMCID: PMC7064782; DOI: 10.1128/mBio.03329-19;

Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Rep. 2020 02 25; 30(8):2481-2488.e5.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 32101697; PMCID: PMC7077502; DOI: 10.1016/j.celrep.2020.02.002;

Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA, Pollak M, Larsson O, Pelletier J, Chio IIC. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nat Commun. 2019 11 13; 10(1):5151.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 31723131; PMCID: PMC6853918; DOI: 10.1038/s41467-019-13086-5;

Huang DS, LeBlanc EV, Shekhar-Guturja T, Robbins N, Krysan DJ, Pizarro J, Whitesell L, Cowen LE, Brown LE. Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors. J Med Chem. 2020 03 12; 63(5):2139-2180. PMID: 31513387; PMCID: PMC7069776; DOI: 10.1021/acs.jmedchem.9b00826;

Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 11 21; 26(11):1586-1593.e3.View Related Profiles.

Beglov, Dmitri
Porco, John
Brown, Lauren
Vajda, Sandor

PMID: 31519508; PMCID: PMC6874763; DOI: 10.1016/j.chembiol.2019.08.008;

Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. J Am Chem Soc. 2019 08 14; 141(32):12891-12900.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 31310112; PMCID: PMC6693944; DOI: 10.1021/jacs.9b06446;

Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, Fu K. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. 2020 01; 34(1):138-150.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 31171817; PMCID: PMC6895415; DOI: 10.1038/s41375-019-0503-z;

Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J Med Chem. 2019 02 28; 62(4):1971-1988.View Related Profiles.

Beglov, Dmitri
Panek, James
Porco, John
Brown, Lauren
Vajda, Sandor

PMID: 30653918; PMCID: PMC6583781; DOI: 10.1021/acs.jmedchem.8b01529;

Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Sci Rep. 2019 02 04; 9(1):1265.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 30718665; PMCID: PMC6361980; DOI: 10.1038/s41598-018-37666-5;

Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA, Tatu U, Brown LE, Pizarro J, Cowen LE. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun. 2019 01 24; 10(1):402.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 30679438; PMCID: PMC6345968; DOI: 10.1038/s41467-018-08248-w;

Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection. J Am Chem Soc. 2019 01 23; 141(3):1312-1323.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 30590924; PMCID: PMC6583776; DOI: 10.1021/jacs.8b11477;

Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Porco, John
Brown, Lauren
Xia, Weiming

PMID: 30776010; PMCID: PMC6474660; DOI: 10.3233/JAD-180923;

Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent Synthesis of Chiral Tetrahydropyrrolodiazepinediones via a One-Pot Intramolecular aza-Michael/Lactamization Sequence. J Org Chem. 2018 12 21; 83(24):15449-15462.View Related Profiles.

Panek, James
Porco, John
Brown, Lauren

PMID: 30458107; PMCID: PMC7203762; DOI: 10.1021/acs.joc.8b02724;

Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741.View Related Profiles.

Porco, John
Snyder, John
Brown, Lauren

PMID: 30648156; PMCID: PMC6311695; DOI: 10.1021/acscentsci.8b00747;

Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Sci Rep. 2018 11 30; 8(1):17519.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 30504817; PMCID: PMC6269514; DOI: 10.1038/s41598-018-35908-0;

Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476.View Related Profiles.

Porco, John
Brown, Lauren
Schaus, Scott

PMID: 29894316; PMCID: PMC6092221; DOI: 10.1097/ALN.0000000000002281;

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2366-E2375.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 29463745; PMCID: PMC5877959; DOI: 10.1073/pnas.1713000115;

Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J, Porco JA. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition. Angew Chem Int Ed Engl. 2017 11 13; 56(46):14479-14482.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 28950418; PMCID: PMC5876029; DOI: 10.1002/anie.201707539;

Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-Thiones and Clioquinol Synergize To Target ß-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci. 2017 Sep 20; 8(9):2039-2055.View Related Profiles.

Brown, Lauren
Schaus, Scott

PMID: 28628299; PMCID: PMC5705239; DOI: 10.1021/acschemneuro.7b00187;

Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10; 9(389).View Related Profiles.

Porco, John
Snyder, John
Brown, Lauren

PMID: 28490664; PMCID: PMC5718051; DOI: 10.1126/scitranslmed.aal2668;

Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European J Org Chem. 2016 Oct; 2016(28):4800-4804.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 28082832; PMCID: PMC5222469; DOI: 10.1002/ejoc.201601003;

Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. EBioMedicine. 2015 Nov; 2(11):1600-6.View Related Profiles.

Porco, John
Brown, Lauren

PMID: 26870784; PMCID: PMC4740292; DOI: 10.1016/j.ebiom.2015.09.018;

Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. J Virol. 2012 Mar; 86(5):2632-40.View Related Profiles.

Filone, Claire Marie
Connor, John
Dower, Ken W
Brown, Lauren
Schaus, Scott

PMID: 22205744; PMCID: PMC3302283; DOI: 10.1128/JVI.05416-11;

Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Org Lett. 2011 Aug 19; 13(16):4228-31.View Related Profiles.

Porco, John
Brown, Lauren
Schaus, Scott

PMID: 21749159; PMCID: PMC4251731; DOI: 10.1021/ol2015658;

Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John
Brown, Lauren
Schaus, Scott

PMID: 21498685; PMCID: PMC3084078; DOI: 10.1073/pnas.1017666108;

Brown LE, Landaverry YR, Davies JR, Milinkevich KA, Ast S, Carlson JS, Oliver AG, Konopelski JP. Progress toward the total synthesis of psymberin/irciniastatin A. J Org Chem. 2009 Aug 07; 74(15):5405-10. PMID: 19572569; PMCID: PMC2736341; DOI: 10.1021/jo9009003;

Chen W, Chen S, Ding F, Wang H, Brown LE, Konopelski JP. Nanoparticle-mediated intervalence transfer. J Am Chem Soc. 2008 Sep 10; 130(36):12156-62. PMID: 18710225

Brown LE, Konopelski JP. Turning the Corner: Recent Advances in the Synthesis of the Welwitindolinones. The New Journal for Organic Synthesis. 2008; 40(5):411-445.

Gerstenberger BS, Lin J, Mimieux YS, Brown LE, Oliver AG, Konopelski JP. Structural characterization of an enantiomerically pure amino acid imidazolide and direct formation of the beta-lactam nucleus from an alpha-amino acid. Org Lett. 2008 Feb 07; 10(3):369-72. PMID: 18181633

Xia J, Brown LE, Konopelski JP. Welwistatin support studies: expansion and limitation of aryllead(IV) coupling reactions. J Org Chem. 2007 Aug 31; 72(18):6885-90. PMID: 17685656; PMCID: PMC2525610; DOI: 10.1021/jo071156l;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 15 distinct years, with a maximum of 10 publications in 2019