Scott Schaus, PhD
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Harvard University
DEng, Boston University

Professor Schaus received his Ph.D. in Organic Chemistry with Eric N. Jacobsen at Harvard University in 1999 and did postdoctoral studies in Andy Myers’ laboratory at Harvard University as an NIH fellow.

Research in the Schaus Group is focused in two major areas: enantioselective catalytic synthetic methodologies for chemical synthesis and biomedical research, the latter conducted at the Boston University Center for Molecular Discovery. Catalytic methods developed in the Schaus Research Laboratories include asymmetric Mannich reactions, enantioselective boronate reactions, and metal-promoted condensation reactions.

Asymmetric Mannich Reactions – The use of cinchona amine, acid, and diol catalysis in the synthesis of chiral amines and heterocycles.

Enantioselective Boronate Catalysis – The development of methodologies to construct chiral building blocks and natural products using boronates.

Biomedical Research – In conjunction with the CMD-BU, advance translational science in the treatment of cancer and infectious disease.

Hepatocellular Carcinoma – Taking on liver cancer in the lab.

Neglected Tropical Disease – BU Researchers Work against Deadly, Disfiguring Disease. Pharmaceutical giant GSK chooses team in its new competition.

Techniques & Resources:

Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules.

The Center for Molecular Discovery (CMD-BU) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of chemical libraries and biomedical research.

Enantioselective Catalytic Boronate Reactions
01/01/2015 - 12/31/2017 (PI)
NIH/National Institute of General Medica

New Compounds for the Treatment of Leishmaniasis
12/30/2013 - 03/01/2017 (PI)
GlaxoSmithKline Investigacion y Desarrol

Treatment of HCC by Targeting LSF with small Molecules
01/01/2014 - 12/31/2014 (PI)
PharmLogic, LLC

Yr Title Project-Sub Proj Pubs
2018 Enantioselective Catalytic Boronate Reactions 5R01GM078240-09 16
2017 NIH-Administrative Support Supplement for Randolf Escobar. 3R01GM078240-07S1 16
2017 Enantioselective Catalytic Boronate Reactions 5R01GM078240-08 16
2016 Enantioselective Catalytic Boronate Reactions 5R01GM078240-07 16
2015 Enantioselective Catalytic Boronate Reactions 2R01GM078240-06A1 16
2012 Library Synthesis Core 5P50GM067041-10-9001 84
2011 The Design and Implementation of Asymmetric Organocatalysis in Synthesis 5R01GM078240-05 16
2011 Library Synthesis Core 5P50GM067041-09-9001 84
2010 Structural and Sterochemically Diverse Heterocycles for the Small Molecule Reposi 5P41GM086180-03 3
2010 The Design and Implementation of Asymmetric Organocatalysis in Synthesis 5R01GM078240-04 16
Showing 10 of 23 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jiang Y, Thomson RJ, Schaus SE. Asymmetric Traceless Petasis Borono-Mannich Reactions of Enals: Reductive Transposition of Allylic Diazenes. Angew Chem Int Ed Engl. 2017 Dec 22; 56(52):16631-16635. PMID: 29110383.
  2. Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-Thiones and Clioquinol Synergize To Target ß-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci. 2017 Sep 20; 8(9):2039-2055. PMID: 28628299.
  3. Allen EE, Zhu C, Panek JS, Schaus SE. Multicomponent Condensation Reactions via ortho-Quinone Methides. Org Lett. 2017 Apr 07; 19(7):1878-1881.View Related Profiles. PMID: 28357870; DOI: 10.1021/acs.orglett.7b00647;.
  4. Jiang Y, Diagne AB, Thomson RJ, Schaus SE. Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions. J Am Chem Soc. 2017 Feb 08; 139(5):1998-2005. PMID: 28121128; DOI: 10.1021/jacs.6b11937;.
  5. Jiang Y, Schaus SE. Asymmetric Petasis Borono-Mannich Allylation Reactions Catalyzed by Chiral Biphenols. Angew Chem Int Ed Engl. 2017 Feb 01; 56(6):1544-1548. PMID: 28052567; DOI: 10.1002/anie.201611332;.
  6. Chin HG, Ponnaluri VK, Zhang G, Estève PO, Schaus SE, Hansen U, Pradhan S. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget. 2016 Dec 13; 7(50):83627-83640. PMID: 27845898; DOI: 10.18632/oncotarget.13271;.
  7. Pham LM, Carvalho L, Schaus S, Kolaczyk ED. Perturbation Detection Through Modeling of Gene Expression on a Latent Biological Pathway Network: A Bayesian hierarchical approach. J Am Stat Assoc. 2016; 111(513):73-92. PMID: 27647944.
  8. Barbato KS, Luan Y, Ramella D, Panek JS, Schaus SE. Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols. Org Lett. 2015 Dec 4; 17(23):5812-5.View Related Profiles. PMID: 26576776; PMCID: PMC4671505; DOI: 10.1021/acs.orglett.5b02954;.
  9. Rajasekaran D, Siddiq A, Willoughby JL, Biagi JM, Christadore LM, Yunes SA, Gredler R, Jariwala N, Robertson CL, Akiel MA, Shen XN, Subler MA, Windle JJ, Schaus SE, Fisher PB, Hansen U, Sarkar D. Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model. Oncotarget. 2015 Sep 22; 6(28):26266-77. PMID: 26313006; PMCID: PMC4694900; DOI: 10.18632/oncotarget.4656;.
  10. Luan Y, Barbato KS, Moquist PN, Kodama T, Schaus SE. Enantioselective synthesis of 1,2-dihydronaphthalene-1-carbaldehydes by addition of boronates to isochromene acetals catalyzed by tartaric acid. J Am Chem Soc. 2015 Mar 11; 137(9):3233-6. PMID: 25715172; PMCID: PMC4666678; DOI: 10.1021/jacs.5b00757;.
Showing 10 of 62 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 62 publications over 19 distinct years, with a maximum of 10 publications in 2011

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590 Commonwealth Ave
Boston MA 02215
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(617) 353-6466 (fax)

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