Scott Schaus | Profiles RNS

Scott Schaus, PhD

Professor

Boston University College of Arts and Sciences

Dept of Chemistry

PhD, Harvard University
DEng, Boston University

Websites

	Chemistry Faculty
	Center for Molecular Discovery (BU-CMD)
	Public Relations - BU Experts
	Google Scholar
	My NCBI
	LinkedIn

Professor Schaus received his Ph.D. in Organic Chemistry with Eric N. Jacobsen at Harvard University in 1999 and did postdoctoral studies in Andy Myers’ laboratory at Harvard University as an NIH fellow.

Research in the Schaus Group is focused in two major areas: enantioselective catalytic synthetic methodologies for chemical synthesis and biomedical research, the latter conducted at the Boston University Center for Molecular Discovery. Catalytic methods developed in the Schaus Research Laboratories include asymmetric Mannich reactions, enantioselective boronate reactions, and metal-promoted condensation reactions.

Asymmetric Mannich Reactions – The use of cinchona amine, acid, and diol catalysis in the synthesis of chiral amines and heterocycles.

Enantioselective Boronate Catalysis – The development of methodologies to construct chiral building blocks and natural products using boronates.

Biomedical Research – In conjunction with the CMD-BU, advance translational science in the treatment of cancer and infectious disease.

Hepatocellular Carcinoma – Taking on liver cancer in the lab.

Neglected Tropical Disease – BU Researchers Work against Deadly, Disfiguring Disease. Pharmaceutical giant GSK chooses team in its new competition.

Techniques & Resources:

Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules.

The Center for Molecular Discovery (CMD-BU) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of chemical libraries and biomedical research.

Assistant Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

2004-2009 NSF CAREER Award

2002-2004 Research Corporation: Research Innovation Award

1999-2001 National Institutes of Health Postdoctoral Fellow

1995-1999 Ford Foundation Predoctoral Fellow

1994 Phi Beta Kappa

BU Research
NIH RePORTER Research

Advancement of a poxvirus inhibitor
03/12/2020 - 02/28/2025 (Co-PI)
PI: John H. Connor, PhD
NIH/National Institute of Allergy & Infectious Diseases
1R01AI151559-01

Accelerating General Anesthetic Discovery and Mechanisms Research with Zebrafish
08/01/2018 - 07/31/2021 (Subcontract Co-PI)
Massachusetts General Hospital NIH NIGMS
5R01GM128989-02

Treatment of HCC by Targeting LSF with small Molecules
02/10/2020 - 09/10/2020 (PI)
Shepherd Therapeutics

Enantioselective Catalytic Boronate Reactions
01/01/2015 - 12/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM078240-09

High-Throughput Chemistry Platform (HTCP) for Reaction Screening
01/01/2018 - 03/31/2019 (Co-PI)
PI: Aaron Beeler, PhD
Department of Defense/DARPA

New Compounds for the Treatment of Leishmaniasis
12/30/2013 - 03/01/2017 (PI)
GlaxoSmithKline Investigacion y Desarrollo, S.L.

Treatment of HCC by Targeting LSF with small Molecules
01/01/2014 - 12/31/2014 (PI)
PharmLogic, LLC

Title

Yr	Title	Project-Sub Proj	Pubs
2020	Advancement of poxvirus inhibitor	1R01AI151559-01
2020	Advancement of poxvirus inhibitor	1R01AI151559-01
2018	Enantioselective Catalytic Boronate Reactions	5R01GM078240-09	26
2017	NIH-Administrative Support Supplement for Randolf Escobar.	3R01GM078240-07S1	26
2017	Enantioselective Catalytic Boronate Reactions	5R01GM078240-08	26
2016	Enantioselective Catalytic Boronate Reactions	5R01GM078240-07	26
2015	Enantioselective Catalytic Boronate Reactions	2R01GM078240-06A1	26
2012	Library Synthesis Core	5P50GM067041-10-9001	103
2011	The Design and Implementation of Asymmetric Organocatalysis in Synthesis	5R01GM078240-05	26
2011	Library Synthesis Core	5P50GM067041-09-9001	103

Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Willoughby JLS, George K, Roberto MP, Chin HG, Stoiber P, Shin H, Pedamallu CS, Schaus SE, Fitzgerald K, Shah J, Hansen U. Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence. BMC Cancer. 2020 Jun 15; 20(1):552. PMID: 32539694

Stoiber P, Ekladious I, Zhao Q, Colson YL, Schaus SE, Hansen U, Grinstaff MW. Expansile Nanoparticles Encapsulate Factor Quinolinone Inhibitor 1 and Accumulate in Murine Liver upon Intravenous Administration. Biomacromolecules. 2020 04 13; 21(4):1499-1506.View Related Profiles.

Grinstaff, Mark
Schaus, Scott

PMID: 32101401

Chin HG, Esteve PO, Ruse C, Lee J, Schaus SE, Pradhan S, Hansen U. The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates a-tubulin. J Biol Chem. 2020 04 03; 295(14):4748-4759. PMID: 32111740

Smith MJ, Reichl KD, Escobar RA, Heavey TJ, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. J Am Chem Soc. 2019 01 09; 141(1):148-153.View Related Profiles.

Coker, David
Porco, John
Schaus, Scott

PMID: 30566336

Wong CR, Hummel G, Cai Y, Schaus SE, Panek JS. [4 + 2]-Cycloaddition and 1,4-Addition of ortho-Quinone Methides by a Chiral Crotyl Silane. Org Lett. 2019 01 04; 21(1):32-35.View Related Profiles.

Panek, James
Schaus, Scott

PMID: 30557029

Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 29894316

Christadore L, Grinstaff MW, Schaus SE. Fluorescent Dendritic Micro-Hydrogels: Synthesis, Analysis and Use in Single-Cell Detection. Molecules. 2018 Apr 18; 23(4).View Related Profiles.

Grinstaff, Mark
Schaus, Scott

PMID: 29669998

Jiang Y, Thomson RJ, Schaus SE. Asymmetric Traceless Petasis Borono-Mannich Reactions of Enals: Reductive Transposition of Allylic Diazenes. Angew Chem Int Ed Engl. 2017 12 22; 56(52):16631-16635. PMID: 29110383

Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-Thiones and Clioquinol Synergize To Target ß-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci. 2017 Sep 20; 8(9):2039-2055. PMID: 28628299

Allen EE, Zhu C, Panek JS, Schaus SE. Multicomponent Condensation Reactions via ortho-Quinone Methides. Org Lett. 2017 04 07; 19(7):1878-1881.View Related Profiles.

Panek, James
Schaus, Scott

PMID: 28357870; DOI: 10.1021/acs.orglett.7b00647;

Showing 10 of 69 results. Show More

Jiang Y, Diagne AB, Thomson RJ, Schaus SE. Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions. J Am Chem Soc. 2017 02 08; 139(5):1998-2005. PMID: 28121128; DOI: 10.1021/jacs.6b11937;

Jiang Y, Schaus SE. Asymmetric Petasis Borono-Mannich Allylation Reactions Catalyzed by Chiral Biphenols. Angew Chem Int Ed Engl. 2017 02 01; 56(6):1544-1548. PMID: 28052567; DOI: 10.1002/anie.201611332;

Chin HG, Ponnaluri VK, Zhang G, Estève PO, Schaus SE, Hansen U, Pradhan S. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget. 2016 Dec 13; 7(50):83627-83640. PMID: 27845898; DOI: 10.18632/oncotarget.13271;

Pham LM, Carvalho L, Schaus S, Kolaczyk ED. Perturbation Detection Through Modeling of Gene Expression on a Latent Biological Pathway Network: A Bayesian hierarchical approach. J Am Stat Assoc. 2016; 111(513):73-92. PMID: 27647944

Barbato KS, Luan Y, Ramella D, Panek JS, Schaus SE. Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols. Org Lett. 2015 Dec 4; 17(23):5812-5.View Related Profiles.

Panek, James
Schaus, Scott

PMID: 26576776; PMCID: PMC4671505; DOI: 10.1021/acs.orglett.5b02954;

Rajasekaran D, Siddiq A, Willoughby JL, Biagi JM, Christadore LM, Yunes SA, Gredler R, Jariwala N, Robertson CL, Akiel MA, Shen XN, Subler MA, Windle JJ, Schaus SE, Fisher PB, Hansen U, Sarkar D. Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model. Oncotarget. 2015 Sep 22; 6(28):26266-77. PMID: 26313006; PMCID: PMC4694900; DOI: 10.18632/oncotarget.4656;

Luan Y, Barbato KS, Moquist PN, Kodama T, Schaus SE. Enantioselective synthesis of 1,2-dihydronaphthalene-1-carbaldehydes by addition of boronates to isochromene acetals catalyzed by tartaric acid. J Am Chem Soc. 2015 Mar 11; 137(9):3233-6. PMID: 25715172; PMCID: PMC4666678; DOI: 10.1021/jacs.5b00757;

Luan Y, Qi Y, Gao H, Ma Q, Schaus SE. Brønsted Acid/Lewis Acid Cooperatively Catalyzed Addition of Diazoester to 2H-chromene Acetals. European J Org Chem. 2014 Nov 01; 2014(31):6868-6872. PMID: 25411552

Luan Y, Yu J, Zhang X, Schaus SE, Wang G. Diastereoselective three-component synthesis of ß-amino carbonyl compounds using diazo compounds, boranes, and acyl imines under catalyst-free conditions. J Org Chem. 2014 May 16; 79(10):4694-8. PMID: 24787904; PMCID: PMC4033649; DOI: 10.1021/jo5003505;

Christadore LM, Pham L, Kolaczyk ED, Schaus SE. Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets. BMC Syst Biol. 2014; 8:7. PMID: 24444313; PMCID: PMC3911882; DOI: 10.1186/1752-0509-8-7;

Luan Y, Qi Y, Yu J, Gao H, Schaus SE. The development of a novel HAuCl4@MOF catalyst and its catalytic application in the formation of dihydrochalcones. RSC Adv. 2014 Jan 01; 4(64):34199-34203. PMID: 26989477

Zandparsa R, Talua NA, Finkelman MD, Schaus SE. An in vitro comparison of shear bond strength of zirconia to enamel using different surface treatments. J Prosthodont. 2014 Feb; 23(2):117-23. PMID: 23890275; DOI: 10.1111/jopr.12075;

Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Org Lett. 2013 Apr 19; 15(8):1962-5.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 23574045; PMCID: PMC3773515; DOI: 10.1021/ol400631b;

Peritore CS, Ho A, Yamamoto BK, Schaus SE. Resveratrol attenuates L-DOPA-induced hydrogen peroxide toxicity in neuronal cells. Neuroreport. 2012 Dec 5; 23(17):989-94.View Related Profiles.

Ho, Angela
Schaus, Scott

PMID: 23114623; DOI: 10.1097/WNR.0b013e32835a4ea4;

Luan Y, Schaus SE. Enantioselective addition of boronates to o-quinone methides catalyzed by chiral biphenols. J Am Chem Soc. 2012 Dec 12; 134(49):19965-8. PMID: 23206197; PMCID: PMC4655814; DOI: 10.1021/ja309076g;

Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK. An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Beilstein J Org Chem. 2012; 8:829-40.View Related Profiles.

Snyder, John
Schaus, Scott

PMID: 23015831; PMCID: PMC3388871

Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SE, Hansen U, Fisher PB, Sarkar D. The transcription factor LSF: a novel oncogene for hepatocellular carcinoma. Am J Cancer Res. 2012; 2(3):269-85. PMID: 22679558; PMCID: PMC3365805

Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4503-8.View Related Profiles.

Schaus, Scott
Grant, Trevor

PMID: 22396589; PMCID: PMC3311344; DOI: 10.1073/pnas.1121601109;

Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. J Virol. 2012 Mar; 86(5):2632-40.View Related Profiles.

Filone, Claire Marie
Connor, John
Dower, Ken W
Schaus, Scott

PMID: 22205744; PMCID: PMC3302283; DOI: 10.1128/JVI.05416-11;

Luan Y, Sun H, Schaus SE. Iron-catalyzed rearrangements and cycloaddition reactions of 2H-chromenes. Org Lett. 2011 Dec 16; 13(24):6480-3. PMID: 22098535; PMCID: PMC4655818; DOI: 10.1021/ol202772k;

Kodama T, Moquist PN, Schaus SE. Enantioselective boronate additions to N-acyl quinoliniums catalyzed by tartaric acid. Org Lett. 2011 Dec 2; 13(23):6316-9. PMID: 22067040; PMCID: PMC4655815; DOI: 10.1021/ol2028702;

Pham L, Christadore L, Schaus S, Kolaczyk ED. Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis. Proc Natl Acad Sci U S A. 2011 Aug 9; 108(32):13347-52. PMID: 21788508; PMCID: PMC3156179; DOI: 10.1073/pnas.1100891108;

Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Org Lett. 2011 Aug 19; 13(16):4228-31.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 21749159; PMCID: PMC4251731; DOI: 10.1021/ol2015658;

Muncipinto G, Moquist PN, Schreiber SL, Schaus SE. Catalytic diastereoselective petasis reactions. Angew Chem Int Ed Engl. 2011 Aug 22; 50(35):8172-5. PMID: 21751322; PMCID: PMC4673970; DOI: 10.1002/anie.201103271;

Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Org Lett. 2011 Aug 5; 13(15):4012-5.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 21740020; PMCID: PMC3146574; DOI: 10.1021/ol201532k;

Barnett DS, Schaus SE. Asymmetric propargylation of ketones using allenylboronates catalyzed by chiral biphenols. Org Lett. 2011 Aug 5; 13(15):4020-3. PMID: 21732609; PMCID: PMC3155969; DOI: 10.1021/ol201535b;

Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John
Schaus, Scott

PMID: 21498685; PMCID: PMC3084078; DOI: 10.1073/pnas.1017666108;

Luan Y, Schaus SE. Multicomponent Mannich reactions with boron enolates derived from diazo esters and 9-BBN. Org Lett. 2011 May 6; 13(9):2510-3. PMID: 21473584; PMCID: PMC4671502; DOI: 10.1021/ol200766t;

Moquist PN, Kodama T, Schaus SE. Enantioselective addition of boronates to chromene acetals catalyzed by a chiral Brønsted acid/Lewis acid system. Angew Chem Int Ed Engl. 2010 Sep 17; 49(39):7096-100. PMID: 20721997; PMCID: PMC3035997; DOI: 10.1002/anie.201003469;

Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS. Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling. J Pharmacol Exp Ther. 2010 Dec; 335(3):799-806. PMID: 20833795; PMCID: PMC2993548; DOI: 10.1124/jpet.110.174029;

Medeiros MR, Narayan RS, McDougal NT, Schaus SE, Porco JA. Skeletal diversity via cationic rearrangements of substituted dihydropyrans. Org Lett. 2010 Jul 16; 12(14):3222-5.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 20550144; PMCID: PMC2937281; DOI: 10.1021/ol101144k;

Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. J Org Chem. 2010 Jul 2; 75(13):4584-90.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 20527786; PMCID: PMC2896495; DOI: 10.1021/jo100889c;

Ting A, Goss JM, McDougal NT, Schaus SE. Brønsted base catalysts. Top Curr Chem. 2010; 291:145-200. PMID: 21494951; DOI: 10.1007/978-3-642-02815-1_23;

Bishop JA, Lou S, Schaus SE. Enantioselective addition of boronates to acyl imines catalyzed by chiral biphenols. Angew Chem Int Ed Engl. 2009; 48(24):4337-40. PMID: 19431168; PMCID: PMC2819183; DOI: 10.1002/anie.200901023;

Barnett DS, Moquist PN, Schaus SE. The mechanism and an improved asymmetric allylboration of ketones catalyzed by chiral biphenols. Angew Chem Int Ed Engl. 2009; 48(46):8679-82. PMID: 19816902; PMCID: PMC2819187; DOI: 10.1002/anie.200904715;

Goss JM, Schaus SE. Enantioselective synthesis of SNAP-7941: chiral dihydropyrimidone inhibitor of MCH1-R. J Org Chem. 2008 Oct 3; 73(19):7651-6. PMID: 18767801; PMCID: PMC2666257; DOI: 10.1021/jo801463j;

Lou S, Schaus SE. Asymmetric petasis reactions catalyzed by chiral biphenols. J Am Chem Soc. 2008 Jun 4; 130(22):6922-3. PMID: 18459782; PMCID: PMC2440570; DOI: 10.1021/ja8018934;

Lou S, Dai P, Schaus SE. Asymmetric Mannich reaction of dicarbonyl compounds with alpha-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones. J Org Chem. 2007 Dec 21; 72(26):9998-10008. PMID: 18047372

Lou S, Moquist PN, Schaus SE. Asymmetric allylboration of acyl imines catalyzed by chiral diols. J Am Chem Soc. 2007 Dec 12; 129(49):15398-404. PMID: 18020334; PMCID: PMC2638762

Dominguez MM, Wathier M, Grinstaff MW, Schaus SE. Immobilized hydrogels for screening of molecular interactions. Anal Chem. 2007 Feb 1; 79(3):1064-6.View Related Profiles.

Grinstaff, Mark
Schaus, Scott

PMID: 17263336

Yeager AR, Min GK, Porco JA, Schaus SE. Exploring skeletal diversity via ring contraction of glycal-derived scaffolds. Org Lett. 2006 Oct 26; 8(22):5065-8.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 17048844

Lou S, Moquist PN, Schaus SE. Asymmetric allylboration of ketones catalyzed by chiral diols. J Am Chem Soc. 2006 Oct 4; 128(39):12660-1. PMID: 17002355

Landon MR, Schaus SE. JEDA: Joint entropy diversity analysis. An information-theoretic method for choosing diverse and representative subsets from combinatorial libraries. Mol Divers. 2006 Aug; 10(3):333-9. PMID: 17031536

Rodgen SA, Schaus SE. Efficient construction of the clerodane decalin core by an asymmetric Morita-Baylis-Hillman reaction/Lewis acid promoted annulation strategy. Angew Chem Int Ed Engl. 2006 Jul 24; 45(30):4929-32. PMID: 16802391

Ting A, Lou S, Schaus SE. Highly diastereoselective asymmetric Mannich reactions of 1,3-dicarbonyls with acyl imines. Org Lett. 2006 May 11; 8(10):2003-6. PMID: 16671767

McDougal NT, Schaus SE. Highly diastereoselective synthesis of bicyclo[3.2.1]octenones through phosphine-mediated condensations of 1,4-dien-3-ones. Angew Chem Int Ed Engl. 2006 May 5; 45(19):3117-9. PMID: 16596692

Lou S, Taoka BM, Ting A, Schaus SE. Asymmetric Mannich reactions of beta-keto esters with acyl imines catalyzed by cinchona alkaloids. J Am Chem Soc. 2005 Aug 17; 127(32):11256-7. PMID: 16089450

Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John
Snyder, John
Schaus, Scott

PMID: 15957938

Beeler AB, Schaus SE, Porco JA. Chemical library synthesis using convergent approaches. Curr Opin Chem Biol. 2005 Jun; 9(3):277-84.View Related Profiles.

Beeler, Aaron
Porco, John
Schaus, Scott

PMID: 15939329

di Bernardo D, Thompson MJ, Gardner TS, Chobot SE, Eastwood EL, Wojtovich AP, Elliott SJ, Schaus SE, Collins JJ. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. Nat Biotechnol. 2005 Mar; 23(3):377-83.View Related Profiles.

Hokanson, Sarah
Schaus, Scott
Elliott, Sean

PMID: 15765094; DOI: 10.1038/nbt1075;

Lou S, Westbrook JA, Schaus SE. Decarboxylative aldol reactions of allyl beta-keto esters via heterobimetallic catalysis. J Am Chem Soc. 2004 Sep 22; 126(37):11440-1. PMID: 15366881

McDougal NT, Schaus SE. Asymmetric Morita-Baylis-Hillman reactions catalyzed by chiral Brønsted acids. J Am Chem Soc. 2003 Oct 8; 125(40):12094-5. PMID: 14518986

Eastwood EL, Schaus SE. Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway. Bioorg Med Chem Lett. 2003 Jul 7; 13(13):2235-7. PMID: 12798341

Myers AG, Glatthar R, Hammond M, Harrington PM, Kuo EY, Liang J, Schaus SE, Wu Y, Xiang JN. Development of an enantioselective synthetic route to neocarzinostatin chromophore and its use for multiple radioisotopic incorporation. J Am Chem Soc. 2002 May 15; 124(19):5380-401. PMID: 11996579

Plowright AT, Schaus SE, Myers AG. Transcriptional response pathways in a yeast strain sensitive to saframycin a and a more potent analog: evidence for a common basis of activity. Chem Biol. 2002 May; 9(5):607-18. PMID: 12031667

Schaus SE, Brandes BD, Larrow JF, Tokunaga M, Hansen KB, Gould AE, Furrow ME, Jacobsen EN. Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)Co(III) complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols. J Am Chem Soc. 2002 Feb 20; 124(7):1307-15. PMID: 11841300

Schaus SE, Cavalieri D, Myers AG. Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11075-80. PMID: 11562456; PMCID: PMC58685

Schaus SE, Jacobsen EN. Asymmetric ring opening of meso epoxides with TMSCN catalyzed by (pybox)lanthanide complexes. Org Lett. 2000 Apr 6; 2(7):1001-4. PMID: 10768207

Furrow ME, Schaus SE, Jacobsen EN. Practical Access to Highly Enantioenriched C-3 Building Blocks via Hydrolytic Kinetic Resolution. J Org Chem. 1998 Oct 02; 63(20):6776-6777. PMID: 11672291

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 69 publications over 21 distinct years, with a maximum of 10 publications in 2011