Scott Schaus, PhD
Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Harvard University
DEng, Boston University




Professor Schaus received his Ph.D. in Organic Chemistry with Eric N. Jacobsen at Harvard University in 1999 and did postdoctoral studies in Andy Myers’ laboratory at Harvard University as an NIH fellow.

Research in the Schaus Group is focused in two major areas: enantioselective catalytic synthetic methodologies for chemical synthesis and biomedical research, the latter conducted at the Boston University Center for Molecular Discovery. Catalytic methods developed in the Schaus Research Laboratories include asymmetric Mannich reactions, enantioselective boronate reactions, and metal-promoted condensation reactions.

Asymmetric Mannich Reactions – The use of cinchona amine, acid, and diol catalysis in the synthesis of chiral amines and heterocycles.

Enantioselective Boronate Catalysis – The development of methodologies to construct chiral building blocks and natural products using boronates.

Biomedical Research – In conjunction with the CMD-BU, advance translational science in the treatment of cancer and infectious disease.

Hepatocellular Carcinoma – Taking on liver cancer in the lab.

Neglected Tropical Disease – BU Researchers Work against Deadly, Disfiguring Disease. Pharmaceutical giant GSK chooses team in its new competition.

Techniques & Resources:

Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules.

The Center for Molecular Discovery (CMD-BU) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of chemical libraries and biomedical research.

Assistant Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Targeting the Genus Leishmania with Small Molecules
03/24/2021 - 02/28/2026 (Multi-PI)
PI: Scott Schaus, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R01AI151639-02

Advancement of a poxvirus inhibitor
03/12/2020 - 02/28/2025 (Co-Investigator)
PI: John H. Connor, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R01AI151559-03

Treatment of HCC by Targeting LSF with small Molecules
02/10/2020 - 08/01/2021 (Multi-PI)
PI: Scott Schaus, PhD
Shepherd Therapeutics


Accelerating General Anesthetic Discovery and Mechanisms Research with Zebrafish
08/01/2018 - 07/31/2021 (Co-Investigator)
Massachusetts General Hospital NIH NIGMS
5R01GM128989-03

Enantioselective Catalytic Boronate Reactions
01/01/2015 - 12/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM078240-09

High-Throughput Chemistry Platform (HTCP) for Reaction Screening
01/01/2018 - 03/31/2019 (Co-Investigator)
PI: Aaron Beeler, PhD
Department of Defense/DARPA


New Compounds for the Treatment of Leishmaniasis
12/30/2013 - 03/01/2017 (PI)
GlaxoSmithKline Investigacion y Desarrollo, S.L.


Treatment of HCC by Targeting LSF with small Molecules
01/01/2014 - 12/31/2014 (PI)
PharmLogic, LLC


COMPLEX CHEMOTYPES: DISCOVERY, METHODOLOGY, AND LIBRARY EXPANSION - LSC
09/01/2010 - 08/31/2014 (Key Person)
PI: John A. Porco, PhD
NIH/National Institute of General Medical Sciences
5P50GM067041-10



Title


Yr Title Project-Sub Proj Pubs
2022 Targeting the Genus Leishmania with Small Molecules 5R01AI151639-02
2022 Advancement of poxvirus inhibitor 5R01AI151559-03
2021 Targeting the Genus Leishmania with Small Molecules 1R01AI151639-01A1
2021 Advancement of poxvirus inhibitor 5R01AI151559-02
2020 Advancement of poxvirus inhibitor 1R01AI151559-01
2018 Enantioselective Catalytic Boronate Reactions 5R01GM078240-09 26
2017 Enantioselective Catalytic Boronate Reactions 5R01GM078240-08 26
2017 NIH-Administrative Support Supplement for Randolf Escobar. 3R01GM078240-07S1 26
2016 Enantioselective Catalytic Boronate Reactions 5R01GM078240-07 26
2015 Enantioselective Catalytic Boronate Reactions 2R01GM078240-06A1 26
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Yunes SA, Willoughby JLS, Kwan JH, Biagi JM, Pokharel N, Chin HG, York EA, Su KC, George K, Shah JV, Emili A, Schaus SE, Hansen U. Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins. PLoS One. 2022; 17(6):e0268857.View Related Profiles. PMID: 35704642; PMCID: PMC9200292; DOI: 10.1371/journal.pone.0268857;
     
  2. Lotfollahzadeh S, Lo D, York EA, Napoleon MA, Yin W, Elzinad N, Le J, Zhang M, Yang X, Morrissey A, Elsadawi M, Zhao Q, Schaus SE, Hansen U, Chitalia VC. Pharmacologic Manipulation of Late SV40 Factor Suppresses Wnt Signaling and Inhibits Growth of Allogeneic and Syngeneic Colon Cancer Xenografts. Am J Pathol. 2022 Aug; 192(8):1167-1185.View Related Profiles. PMID: 35710032
     
  3. Stoiber P, Scribani Rossi P, Pokharel N, Germany JL, York EA, Schaus SE, Hansen U. Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules. Sci Rep. 2021 12 07; 11(1):23564. PMID: 34876605; PMCID: PMC8651680; DOI: 10.1038/s41598-021-02962-0;
     
  4. Willoughby JLS, George K, Roberto MP, Chin HG, Stoiber P, Shin H, Pedamallu CS, Schaus SE, Fitzgerald K, Shah J, Hansen U. Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence. BMC Cancer. 2020 Jun 15; 20(1):552. PMID: 32539694; PMCID: PMC7296649; DOI: 10.1186/s12885-020-07039-1;
     
  5. Stoiber P, Ekladious I, Zhao Q, Colson YL, Schaus SE, Hansen U, Grinstaff MW. Expansile Nanoparticles Encapsulate Factor Quinolinone Inhibitor 1 and Accumulate in Murine Liver upon Intravenous Administration. Biomacromolecules. 2020 04 13; 21(4):1499-1506.View Related Profiles. PMID: 32101401
     
  6. Chin HG, Esteve PO, Ruse C, Lee J, Schaus SE, Pradhan S, Hansen U. The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates a-tubulin. J Biol Chem. 2020 04 03; 295(14):4748-4759. PMID: 32111740; PMCID: PMC7135998; DOI: 10.1074/jbc.RA119.010951;
     
  7. Smith MJ, Reichl KD, Escobar RA, Heavey TJ, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. J Am Chem Soc. 2019 01 09; 141(1):148-153.View Related Profiles. PMID: 30566336; PMCID: PMC6475489; DOI: 10.1021/jacs.8b12520;
     
  8. Wong CR, Hummel G, Cai Y, Schaus SE, Panek JS. [4 + 2]-Cycloaddition and 1,4-Addition of ortho-Quinone Methides by a Chiral Crotyl Silane. Org Lett. 2019 01 04; 21(1):32-35.View Related Profiles. PMID: 30557029
     
  9. Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476.View Related Profiles. PMID: 29894316; PMCID: PMC6092221; DOI: 10.1097/ALN.0000000000002281;
     
  10. Christadore L, Grinstaff MW, Schaus SE. Fluorescent Dendritic Micro-Hydrogels: Synthesis, Analysis and Use in Single-Cell Detection. Molecules. 2018 Apr 18; 23(4).View Related Profiles. PMID: 29669998; PMCID: PMC6017717; DOI: 10.3390/molecules23040936;
     
Showing 10 of 72 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 23 distinct years, with a maximum of 10 publications in 2011

YearPublications
19981
20001
20011
20023
20032
20041
20054
20066
20073
20082
20092
20105
201110
20125
20132
20144
20153
20162
20175
20184
20203
20211
20222

2004-2009 NSF CAREER Award
2002-2004 Research Corporation: Research Innovation Award
1999-2001 National Institutes of Health Postdoctoral Fellow
1995-1999 Ford Foundation Predoctoral Fellow
1994 Phi Beta Kappa
Contact for Mentoring:

590 Commonwealth Ave
Boston MA 02215
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(617) 353-6466 (fax)

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