Joseph Kaserman, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Vermont College of Medicine



Alpha1 antitrypsin deficiency is the most common cause of hereditary liver disease, however, only about 10% of patients with the mutation develop liver disease. The mechanism for why certain patients develop liver disease remains poorly understood. Using hiPS cells we will correct the Z AAT mutation using the CRISPR/Cas9 system to compare syngeneic daughter clones. This will reduce variation due to other genetic differences allowing for a more precise evaluation of the effects from the mutant protein and allow for the creation of a disease signature.

2018 John W. Walsh Translational Research Award
2016 Second Place Laboratory Basic Research Award: Second Place Laboratory Basic Research Award
2010 Alpha Omega Alpha: Inductee
2009 Gold Humanism Honor Society: Inductee
2008 McGraw-Hill/Lange Medical Student Award
2008 Phorplus Wasserman 1951 Prize
2008 Ernest H. Buttles Award for Excellence in Pathology
2008 Ephraim Woll Award for Excellence in Pathology


DEFINING PIMZ AATD LIVER DISEASE SUSCEPTIBILITY WITH CRISPR TARGETED SYNGENEIC IPSCS
07/01/2018 - 06/30/2021 (PI)
Alpha 1 Foundation




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in a1-antitrypsin deficiency. J Hepatol. 2018 Oct; 69(4):851-860.View Related Profiles. PMID: 29879455.
     
  2. Kaserman JE, Wilson AA. Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage. Methods Mol Biol. 2017; 1639:151-160.View Related Profiles. PMID: 28752455.
     
  3. Garcia MI, Kaserman J, Chung YH, Jung JU, Lee SH. Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction. J Virol. 2007 Mar; 81(6):2663-74. PMID: 17182673; PMCID: PMC1866011.
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 2006 and 2017 and 2018

YearPublications
20061
20171
20181
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Alpha1 Antitrypsin Deficiency
iPSCs
Liver Disease Diagnosis
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72 East Concord Street, R-304
Boston MA 02118
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