Joseph Kaserman, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Vermont College of Medicine

Dr. Kaserman is an Assistant Professor of Medicine at the Boston University School of Medicine and a member of the Pulmonary, Allergy, Sleep and Critical Care Medicine section as well as a researcher in the Wilson Lab at the Center for Regenerative Medicine of Boston University and Boston Medical Center. His research has focused on studying the biological underpinnings of the genetic disease alpha-1 antitrypsin deficiency using pluripotent stem cell models combined with gene editing technology in order to rationally develop potential future disease modifying and curative therapies.

Boston University
Pulmonary Center

Boston University
Center for Regenerative Medicine

Defining PiMZ AATD Liver Disease Susceptibility with CRISPR Targeted Syngeneic iPSCs
07/01/2018 - 06/30/2021 (PI)
Alpha 1 Foundation


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 02; 18(2):e1010268.View Related Profiles. PMID: 35120176; PMCID: PMC8849519; DOI: 10.1371/journal.ppat.1010268;
  2. Werder RB, Kaserman JE, Packer MS, Lindstrom-Vautrin J, Villacorta-Martin C, Young LE, Aratyn-Schaus Y, Gregoire F, Wilson AA. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. Mol Ther. 2021 11 03; 29(11):3219-3229.View Related Profiles. PMID: 34217893; PMCID: PMC8571173; DOI: 10.1016/j.ymthe.2021.06.021;
  3. Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 07 14; 15(1):242-255.View Related Profiles. PMID: 32619491; PMCID: PMC7363960; DOI: 10.1016/j.stemcr.2020.06.006;
  4. Kaserman JE, Wilson AA. Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery. Chronic Obstr Pulm Dis. 2018 Sep 15; 5(4):258-266.View Related Profiles. PMID: 30723783; PMCID: PMC6361479; DOI: 10.15326/jcopdf.5.4.2017.0179;
  5. Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in a1-antitrypsin deficiency. J Hepatol. 2018 Oct; 69(4):851-860.View Related Profiles. PMID: 29879455; PMCID: PMC6562205; DOI: 10.1016/j.jhep.2018.05.028;
  6. Kaserman JE, Wilson AA. Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage. Methods Mol Biol. 2017; 1639:151-160.View Related Profiles. PMID: 28752455; PMCID: PMC7252494; DOI: 10.1007/978-1-4939-7163-3_15;
  7. Garcia MI, Kaserman J, Chung YH, Jung JU, Lee SH. Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction. J Virol. 2007 Mar; 81(6):2663-74. PMID: 17182673; PMCID: PMC1866011; DOI: 10.1128/JVI.01733-06;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2018


2018 John W. Walsh Translational Research Award
2016 Second Place Laboratory Basic Research Award: Second Place Laboratory Basic Research Award
2010 Alpha Omega Alpha: Inductee
2009 Gold Humanism Honor Society: Inductee
2008 McGraw-Hill/Lange Medical Student Award
2008 Phorplus Wasserman 1951 Prize
2008 Ernest H. Buttles Award for Excellence in Pathology
2008 Ephraim Woll Award for Excellence in Pathology
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Alpha1 Antitrypsin Deficiency
CRISPR-Cas Systems
Liver Disease Diagnosis
Contact for Mentoring:

72 East Concord Street, R-304
Boston MA 02118
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