Jingyan Han, PhD
Assistant Professor
Boston University School of Medicine
Dept of Vascular Biology

PhD, University of Illinois
MS, Peking University



Jingyan Han, PhD, is an Assistant Professor of Medicine in Vascular Biology at Boston University School of Medicine. She holds a BS, MS, and PhD in Pharmacology. Two years before her initial appointment she worked in Dr. Richard Cohen's Laboratory. She's received funding from the American Heart Association, the NIH, and the Central Society for Clinical Research. She describes her current research as being "focused on defining the role of redox mediated post-translational protein modifications, such as S-glutathione cysteine adducts, in the regulation of micro and macro vascular barrier integrity, in the pathogenesis of atherosclerosis that is the major cause of cardiovascular diseases."

2017-2019 NIH: The role of vascular protein S-glutathionylation in atherosclerosis
2015-2016 CTSI, Boston Univeristy: Protein S-glutathionylation: the potential therapeutic target for cardiovascular disease
2014-2018 AHA: Role of glutaredoxin-1 in endothelial barrier dysfunction and atherosclerosis


Role of protein-S-glutathionylation in endothelial dysfunction and atherosclerosis
09/01/2017 - 08/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
1R56HL130194-01A1

The role of glutaredoxin1 in endothelial barrier function and atherosclerosis
07/01/2014 - 06/30/2018 (PI)
American Heart Association



Retinoic Acid Receptor, Lipid Metabolism, and Fatty Liver Disease
06/01/2016 - 12/31/2016 (PI)
Univ of Texas Health Science CTR - San Antonio NIH-NIDDK



Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 May 31; e201800053.View Related Profiles. PMID: 29855165.
     
  2. Edenbaum H, Han J. Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione. Methods Mol Biol. 2018; 1821:155-163. PMID: 30062411.
     
  3. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles. PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
     
  4. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;.
     
  5. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;.
     
  6. Luo T, Nocon A, Fry J, Sherban A, Rui X, Jiang B, Xu XJ, Han J, Yan Y, Yang Q, Li Q, Zang M. AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity. Diabetes. 2016 Aug; 65(8):2295-310.View Related Profiles. PMID: 27207538; PMCID: PMC4955985; DOI: 10.2337/db15-1122;.
     
  7. Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR. Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano. 2015 Jul 28; 9(7):6785-93. PMID: 26153796; PMCID: PMC4761649; DOI: 10.1021/nn505672x;.
     
  8. Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Control Release. 2015 Jul 28; 210:39-47. PMID: 25966362; PMCID: PMC4793278; DOI: 10.1016/j.jconrel.2015.05.006;.
     
  9. Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem. 2014 Mar 21; 289(12):8633-44.View Related Profiles. PMID: 24482236; PMCID: PMC3961686; DOI: 10.1074/jbc.M113.517219;.
     
  10. Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA, Bachschmid MM. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem. 2014 Mar 14; 289(11):7293-306.View Related Profiles. PMID: 24451382; PMCID: PMC3953247; DOI: 10.1074/jbc.M113.520403;.
     
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 11 distinct years, with a maximum of 3 publications in 2009 and 2010 and 2012 and 2013 and 2016

YearPublications
20081
20093
20103
20112
20123
20133
20142
20152
20163
20171
20181
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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