Jingyan Han, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Vascular Biology

PhD, University of Illinois
MS, Peking University
BA, Peking University

Pronouns: she/her/hers

Welcome to Dr. Han’s lab, part of the Vascular Biology Section/Department of Medicine,Whitaker Cardiovascular Research Institute, and Sargent College at Boston University. We study the molecular mechanisms of atherosclerotic cardiovascular disease with a particular focus on the role of redox signaling in vascular endothelial cell dysfunction in response to various risk factors including hyperlipidemia, aging, and chronic alcohol abuse, which are supported by NIH grants. (National Heart Lung and Blood Institute—R01HL137771, National Institute of Aging—R21AG058983, and National Institute of Alcohol Abuse and Alcoholism—R21AA026922) Animal models of atherosclerosis, vascular aging, and chronic binge drinking have been established, and conditional tissue specific transgenic and knockout mice strains are employed to decipher the in vivo role of thiol redox signaling in vascular dysfunction and development of atherosclerosis. Isolated endothelial cells from human subjects with cardiovascular disease and cultured human aortic endothelial cells, as well redox proteomics and various molecular biology methods are used to elucidate the molecular mechanism underlying redox regulation of endothelial function. (Representative publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045950/pdf/main.pdf).

In addition to understanding the molecular mechanism of atherosclerosis, our research interests also lie in developing multidisciplinary approach to measuring vascular function in murine animals, and to targeted delivery of nanomedicine to cardiovascular system. We have developed a novel optical coherence tomography-based vascular imaging system enabling to real-time measure 3D angiography and hemodynamics of femoral artery of mouse models in vivo, which is noninvasive, label-free, contact-free, and high degree of automation in data acquisition and processing.(Representative publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226329/) We also initiated an exciting collaborative project with biotech company investigating the targeted delivery of redox-controllable nanoparticles to cardiovascular system in vivo, which has been a great challenge for drug delivery and treatment for cardiovascular disease.

Boston University
Whitaker Cardiovascular Institute

Role of protein-S-glutathionylation in endothelial dysfunction and atherosclerosis
02/04/2020 - 01/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute

Alcohol-induced dysregulation of thiol homeostasis and endothelial function
05/15/2019 - 04/30/2022 (Multi-PI)
PI: Jingyan Han, PhD
NIH/National Institute on Alcohol Abuse and Alcoholism

Protein S-glutathionylation and vascular dysfunction with aging
08/01/2018 - 05/31/2021 (PI)
NIH/National Institute on Aging

Role of protein-S-glutathionylation in endothelial dysfunction and atherosclerosis
09/01/2017 - 08/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute

The role of glutaredoxin1 in endothelial barrier function and atherosclerosis
07/01/2014 - 06/30/2018 (PI)
American Heart Association

Retinoic Acid Receptor, Lipid Metabolism, and Fatty Liver Disease
06/01/2016 - 12/31/2016 (PI)
Univ of Texas Health Science CTR - San Antonio NIH-NIDDK


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Budbazar E, Sulser Ponce De Leon S, Tsukahara Y, Liu H, Huangfu Y, Wang Y, Seabra PM, Yang X, Goodman JB, Wan X, Chitalia V, Han J, Seta F. Redox Dysregulation of Vascular Smooth Muscle Sirtuin-1 in Thoracic Aortic Aneurysm in Marfan Syndrome. Arterioscler Thromb Vasc Biol. 2023 Aug; 43(8):e339-e357.View Related Profiles. PMID: 37288573; PMCID: PMC10524979; DOI: 10.1161/ATVBAHA.123.319145;
  2. Zhang Z, Gan Q, Han J, Tao Q, Qiu WQ, Madri JA. CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease. J Cereb Blood Flow Metab. 2023 Jul; 43(7):1027-1041.View Related Profiles. PMID: 37051650; PMCID: PMC10291450; DOI: 10.1177/0271678X231170041;
  3. Zhou Y, Hou D, Marigo CC, Bonelli J, Rocas P, Cheng F, Yang X, Rocas J, Hamberg NM, Han J. Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis. iScience. 2022 Nov 18; 25(11):105390. PMID: 36345337; PMCID: PMC9636043; DOI: 10.1016/j.isci.2022.105390;
  4. Zhou Y, Wan X, Seidel K, Zhang M, Goodman JB, Seta F, Hamburg N, Han J. Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE-/- Mice. J Am Heart Assoc. 2021 09 21; 10(18):e020441.View Related Profiles. PMID: 34533042; PMCID: PMC8649520; DOI: 10.1161/JAHA.120.020441;
  5. Seidel K, Wan X, Zhang M, Zhou Y, Zang M, Han J. Alcohol Binge Drinking Selectively Stimulates Protein S-Glutathionylation in Aorta and Liver of ApoE-/- Mice. Front Cardiovasc Med. 2021; 8:649813.View Related Profiles. PMID: 33796575; PMCID: PMC8007763; DOI: 10.3389/fcvm.2021.649813;
  6. Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid Redox Signal. 2020 04 01; 32(10):677-700.View Related Profiles. PMID: 31813265; PMCID: PMC7047114; DOI: 10.1089/ars.2019.7963;
  7. Weinberg EO, Ferran B, Tsukahara Y, Hatch MMS, Han J, Murdoch CE, Matsui R. IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages. PLoS One. 2019; 14(1):e0210827.View Related Profiles. PMID: 30682073; PMCID: PMC6347181; DOI: 10.1371/journal.pone.0210827;
  8. Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 11; 11(11):e201800053.View Related Profiles. PMID: 29855165; PMCID: PMC6226329; DOI: 10.1002/jbio.201800053;
  9. Edenbaum H, Han J. Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione. Methods Mol Biol. 2018; 1821:155-163. PMID: 30062411
  10. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles. PMID: 27958883; PMCID: PMC5563925; DOI: 10.1089/ars.2016.6716;
Showing 10 of 32 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 16 distinct years, with a maximum of 3 publications in 2009 and 2010 and 2012 and 2013 and 2016


2019-2021 Boston University School of Medicine: Evans Jr. Faculty Research Merit Award
2017-2019 NIH: The role of vascular protein S-glutathionylation in atherosclerosis
2015-2016 CTSI, Boston Univeristy: Protein S-glutathionylation: the potential therapeutic target for cardiovascular disease
2014-2018 AHA: Role of glutaredoxin-1 in endothelial barrier dysfunction and atherosclerosis
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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