Jingyan Han, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Vascular Biology

PhD, University of Illinois
MS, Peking University

Pronouns: she/her/hers



Welcome to Dr. Han’s lab, part of the Vascular Biology Section/Department of Medicine,Whitaker Cardiovascular Research Institute, and Sargent College at Boston University. We study the molecular mechanisms of atherosclerotic cardiovascular disease with a particular focus on the role of redox signaling in vascular endothelial cell dysfunction in response to various risk factors including hyperlipidemia, aging, and chronic alcohol abuse, which are supported by NIH grants. (National Heart Lung and Blood Institute—R01HL137771, National Institute of Aging—R21AG058983, and National Institute of Alcohol Abuse and Alcoholism—R21AA026922) Animal models of atherosclerosis, vascular aging, and chronic binge drinking have been established, and conditional tissue specific transgenic and knockout mice strains are employed to decipher the in vivo role of thiol redox signaling in vascular dysfunction and development of atherosclerosis. Isolated endothelial cells from human subjects with cardiovascular disease and cultured human aortic endothelial cells, as well redox proteomics and various molecular biology methods are used to elucidate the molecular mechanism underlying redox regulation of endothelial function. (Representative publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045950/pdf/main.pdf).

In addition to understanding the molecular mechanism of atherosclerosis, our research interests also lie in developing multidisciplinary approach to measuring vascular function in murine animals, and to targeted delivery of nanomedicine to cardiovascular system. We have developed a novel optical coherence tomography-based vascular imaging system enabling to real-time measure 3D angiography and hemodynamics of femoral artery of mouse models in vivo, which is noninvasive, label-free, contact-free, and high degree of automation in data acquisition and processing.(Representative publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226329/) We also initiated an exciting collaborative project with biotech company investigating the targeted delivery of redox-controllable nanoparticles to cardiovascular system in vivo, which has been a great challenge for drug delivery and treatment for cardiovascular disease.

Member
Boston University
Whitaker Cardiovascular Institute



2019-2021 Boston University School of Medicine: Evans Jr. Faculty Research Merit Award
2017-2019 NIH: The role of vascular protein S-glutathionylation in atherosclerosis
2015-2016 CTSI, Boston Univeristy: Protein S-glutathionylation: the potential therapeutic target for cardiovascular disease
2014-2018 AHA: Role of glutaredoxin-1 in endothelial barrier dysfunction and atherosclerosis


Role of protein-S-glutathionylation in endothelial dysfunction and atherosclerosis
02/04/2020 - 01/31/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL137771-01A1

Protein S-glutathionylation and vascular dysfunction with aging
08/01/2018 - 05/31/2021 (PI)
NIH/National Institute on Aging
5R21AG058983-02

Alcohol-induced dysregulation of thiol homeostasis and endothelial function
05/15/2019 - 04/30/2021 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R21AA026922-02

Role of protein-S-glutathionylation in endothelial dysfunction and atherosclerosis
09/01/2017 - 08/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
1R56HL130194-01A1

The role of glutaredoxin1 in endothelial barrier function and atherosclerosis
07/01/2014 - 06/30/2018 (PI)
American Heart Association



Retinoic Acid Receptor, Lipid Metabolism, and Fatty Liver Disease
06/01/2016 - 12/31/2016 (PI)
Univ of Texas Health Science CTR - San Antonio NIH-NIDDK


Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid Redox Signal. 2020 04 01; 32(10):677-700.View Related Profiles. PMID: 31813265
     
  2. Weinberg EO, Ferran B, Tsukahara Y, Hatch MMS, Han J, Murdoch CE, Matsui R. IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages. PLoS One. 2019; 14(1):e0210827.View Related Profiles. PMID: 30682073
     
  3. Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 11; 11(11):e201800053.View Related Profiles. PMID: 29855165
     
  4. Edenbaum H, Han J. Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione. Methods Mol Biol. 2018; 1821:155-163. PMID: 30062411
     
  5. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles. PMID: 27958883; DOI: 10.1089/ars.2016.6716;
     
  6. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;
     
  7. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;
     
  8. Luo T, Nocon A, Fry J, Sherban A, Rui X, Jiang B, Xu XJ, Han J, Yan Y, Yang Q, Li Q, Zang M. AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity. Diabetes. 2016 Aug; 65(8):2295-310.View Related Profiles. PMID: 27207538; PMCID: PMC4955985; DOI: 10.2337/db15-1122;
     
  9. Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR. Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano. 2015 Jul 28; 9(7):6785-93. PMID: 26153796; PMCID: PMC4761649; DOI: 10.1021/nn505672x;
     
  10. Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Control Release. 2015 Jul 28; 210:39-47. PMID: 25966362; PMCID: PMC4793278; DOI: 10.1016/j.jconrel.2015.05.006;
     
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 13 distinct years, with a maximum of 3 publications in 2009 and 2010 and 2012 and 2013 and 2016

YearPublications
20081
20093
20103
20112
20123
20133
20142
20152
20163
20171
20182
20191
20201

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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