Hui Feng | Profiles RNS

Hui Feng, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

MD, Beijing Medical University
PhD, University of Georgia
MS, Peking Union Medical College

Websites

	Feng Lab website
	Pharmacology, Physiology & Biophysics Faculty
	International meeting speaker
	Cancer Cell paper preview
	Fis'ing for Answers

ORCID : 0000-0003-1318-821X

Cancer Research: Dr. Feng is Director of the Laboratory of Zebrafish Genetics and Cancer Therapeutics. Dr. Feng’s research interests focus on identifying novel genes and pathways that are essential for MYC-related tumor transformation and progression, particularly for T-Lymphoblastic Lymphoma/Leukemia, Neuroblastoma and Breast Cancer. The research strategy of Dr. Feng’s research is to combine the analysis of human cancer cells with the genetic and imaging capacities of the zebrafish system.

Current research areas in Dr. Feng’s laboratory include:
1) To determine the molecular mechanisms underlying tumor cell intravasation and tumor progression.
2) To identify novel genes and pathways that, when mutated, delay the initiation and progression of MYC-related cancers.
3) To test the identified genes’ therapeutic potential in treating MYC-related cancers and to characterize their molecular relevance to MYC.

The long-term goal of Dr. Feng’s research is to discover novel molecular therapies to target critical components of MYC-driven oncogenic pathways, thus providing treatment alternatives that are more specific and less toxic.

Diversity, Equity, Inclusion and Accessibility

The Feng laboratory at Boston University (www.bu.edu/zgct) is committed to training the next generation of researchers throughout the world with all ethnicities and cultural backgrounds. Ever since the opening of the laboratory in October 2011, the Feng laboratory has already trained over thirty undergraduate researchers, ten graduate students, thirteen postdoctoral fellows, and nine visiting scientists – many of whom have gone on to pursue a career in academic institutes or industry. Among the fifty-four trainees that Dr. Feng mentored in the past five years, thirty-two are females, nine are underrepresented, and five are disabled. In addition, Dr. Feng has been leading drug discovery efforts as a co-leader for the past ten years in the zebrafish disease model society (ZDMS). Currently, Dr. Feng serves on the board of directors and as the chair of the diversity, equity, and inclusion committee in the ZDMS. She has been an active advocate in promoting trainee diversity and inclusion in her department, school of medicine, and the scientific community at large.

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research

Mechanisms of lmmunosuppression in MYCN-driven Neuroblastoma
12/01/2024 - 11/30/2029 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1R01NS140967-01

The Role of DLST in Leukemogenesis
08/07/2018 - 07/31/2025 (PI)
NIH/National Cancer Institute
5R01CA215059-05

A novel immunotherapeutic strategy for neuronal cancers
07/01/2023 - 06/30/2025 (Key Person / Mentor)
PI: Xiaodan Qin, PhD
Warren Alpert Foundation

Novel family of cellulose acetate fluorescent nanomaterials for bioimaging applications
08/01/2020 - 12/31/2024 (Subcontract PI)
Trustees of Tufts College, Inc National Science Fdn

Targeting CKLF as an Immunotherapeutic Approach to Treat MYCN-driven High-risk Neuroblastoma
09/15/2022 - 09/14/2024 (PI)
Alex's Lemonade Stand Foundation for Childhood Cancer

Novel Nanobody Development to Boost Immunotherapy
05/01/2024 - 08/31/2024 (PI)
Alex's Lemonade Stand Foundation for Childhood Cancer

Personnel Agreement for Research Services of Hui Feng
12/22/2022 - 12/21/2023 (Key Person)
PI: David H. Farb, PhD
Department of Veterans Administration, Bedford

The role of DLST in Treg-mediated immunosuppression of High-risk Neuroblastoma
04/01/2023 - 05/30/2023 (PI)
Alex's Lemonade Stand Foundation for Childhood Cancer

Regulatory Role and Targetability of UFDI in MYC-drlven Leukemia
01/01/2018 - 12/31/2022 (PI)
American Cancer Society, Inc.

Targeting DLST as a Novel Therapeutic Approach for Neuroblastoma
07/01/2018 - 06/30/2019 (PI)
St. Baldrick's Foundation

Showing 10 of 17 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024 Apr 02; 14(1):7526. PMID: 38565852; PMCID: PMC10987645; DOI: 10.1038/s41598-024-54655-z;

Qin X, Lam A, Zhang X, Sengupta S, Iorgulescu JB, Ni H, Das S, Rager M, Zhou Z, Zuo T, Meara GK, Floru AE, Kemet C, Veerapaneni D, Kashy D, Lin L, Lloyd K, Kwok L, Smith KS, Nagaraju RT, Meijers R, Ceol C, Liu CT, Alexandrescu S, Wu CJ, Keskin DB, George RE, Feng H. CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness. Sci Adv. 2024 Mar 15; 10(11):eadh9547.View Related Profiles.

Liu, Ching-Ti
Feng, Hui
Zuo, Tao

PMID: 38489372; PMCID: PMC10942121; DOI: 10.1126/sciadv.adh9547;

Xiao B, Landesman-Bollag E, Feng H. What value do zebrafish have to anticancer drug discovery? Expert Opin Drug Discov. 2024 Apr; 19(4):369-375. PMID: 38327017; PMCID: PMC10950524; DOI: 10.1080/17460441.2024.2313454;

Laroche FJF, Li S, Shen N, Hwang SK, Nguyen G, Yu W, Wong CK, Quinton RJ, Berman JN, Liu CT, Singh A, Ganem NJ, Thiagalingam S, Feng H. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 2023 Mar 23; 12(7).View Related Profiles.

Wong, Chen Khuan
Liu, Ching-Ti
Feng, Hui
Ganem, Neil
Quinton, Ryan
Thiagalingam, Sam

PMID: 37048053; PMCID: PMC10093541; DOI: 10.3390/cells12070980;

Wang Y, Shen N, Spurlin G, Korm S, Huang S, Anderson NM, Huiting LN, Liu H, Feng H. a-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting. Cancers (Basel). 2022 Jun 16; 14(12).View Related Profiles.

Feng, Hui
Huiting, Leah
Korm, Sovannarith

PMID: 35740646; PMCID: PMC9221025; DOI: 10.3390/cancers14122983;

Kemet C, Hill E, Feng H. Fishing for drugs. Elife. 2022 02 08; 11. PMID: 35133278; PMCID: PMC8824469; DOI: 10.7554/eLife.76632;

Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289.View Related Profiles.

Liu, Ching-Ti
Feng, Hui
Shen, Ning
Shirihai, Orian
Korm, Sovannarith

PMID: 34785772; PMCID: PMC8595664; DOI: 10.1038/s42003-021-02805-8;

Friedlander JE, Shen N, Zeng A, Korm S, Feng H. Failure to Guard: Mitochondrial Protein Quality Control in Cancer. Int J Mol Sci. 2021 Aug 02; 22(15).View Related Profiles.

Feng, Hui
Shen, Ning
Korm, Sovannarith

PMID: 34361072; PMCID: PMC8348654; DOI: 10.3390/ijms22158306;

Anderson NM, Qin X, Finan JM, Lam A, Athoe J, Missiaen R, Skuli N, Kennedy A, Saini AS, Tao T, Zhu S, Nissim I, Look AT, Qing G, Simon MC, Feng H. Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer Res. 2021 Sep 01; 81(17):4417-4430. PMID: 34233924; PMCID: PMC8577318; DOI: 10.1158/0008-5472.CAN-20-2153;

Miao KZ, Kim GY, Meara GK, Qin X, Feng H. Tipping the Scales With Zebrafish to Understand Adaptive Tumor Immunity. Front Cell Dev Biol. 2021; 9:660969.View Related Profiles.

Feng, Hui
Qin, Xiaodan

PMID: 34095125; PMCID: PMC8173129; DOI: 10.3389/fcell.2021.660969;

Showing 10 of 51 results. Show More

Zhou Y, Lian H, Shen N, Korm S, Kwok Ping Lam A, Layton O, Huiting LN, Li D, Miao K, Zeng A, Landesman-Bollag E, Seldin DC, Fu H, Hong L, Feng H. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 2021 05 01; 106(5):1461-1465.View Related Profiles.

Landesman, Esther
Feng, Hui
Huiting, Leah
Korm, Sovannarith

PMID: 32817283; PMCID: PMC8094085; DOI: 10.3324/haematol.2020.246918;

Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997.View Related Profiles.

Gabel, Christopher
Boas, David
Wirak, Gregory
Feng, Hui
Yin, Wenqing
Qin, Xiaodan

PMID: 33654671; PMCID: PMC7829172; DOI: 10.21037/qims-20-806;

Qin X, Denton WD, Huiting LN, Smith KS, Feng H. Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity. Crit Rev Biochem Mol Biol. 2020 08; 55(4):322-353.View Related Profiles.

Feng, Hui
Huiting, Leah
Qin, Xiaodan

PMID: 32633575; PMCID: PMC7644137; DOI: 10.1080/10409238.2020.1784085;

Qin X, Laroche FFJ, Peerzade SAMA, Lam A, Sokolov I, Feng H. In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish. J Vis Exp. 2020 05 08; (159).View Related Profiles.

Feng, Hui
Qin, Xiaodan

PMID: 32449736; PMCID: PMC7694440; DOI: 10.3791/61187;

Igwebuike C, Yaglom J, Huiting L, Feng H, Campbell JD, Wang Z, Havasi A, Pimentel D, Sherman MY, Borkan SC. Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell Death Dis. 2020 04 03; 11(4):217.View Related Profiles.

Havasi, Andrea
Pimentel, David
Feng, Hui
Campbell, Joshua
Huiting, Leah
Borkan, Steven
Wang, Zhiyong

PMID: 32245975; PMCID: PMC7125232; DOI: 10.1038/s41419-020-2382-7;

Song W, Matlock A, Fu S, Qin X, Feng H, Gabel CV, Tian L, Yi J. LED array reflectance microscopy for scattering-based multi-contrast imaging. Opt Lett. 2020 Apr 01; 45(7):1647-1650.View Related Profiles.

Gabel, Christopher
Feng, Hui

PMID: 32235964; PMCID: PMC7278208; DOI: 10.1364/OL.387434;

Jiang J, Wang J, Yue M, Cai X, Wang T, Wu C, Su H, Wang Y, Han M, Zhang Y, Zhu X, Jiang P, Li P, Sun Y, Xiao W, Feng H, Qing G, Liu H. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. Cancer Cell. 2020 Feb 10; 37(2):200-215.e5. PMID: 32049046; PMCID: PMC7321798; DOI: 10.1016/j.ccell.2020.01.001;

Wong CK, Lambert AW, Ozturk S, Papageorgis P, Lopez D, Shen N, Sen Z, Abdolmaleky HM, Gyorffy B, Feng H, Thiagalingam S. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Mol Cancer Res. 2020 03; 18(3):414-423.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Lopez, Delia
Feng, Hui
Shen, Ning
Thiagalingam, Sam

PMID: 31932471; PMCID: PMC7115128; DOI: 10.1158/1541-7786.MCR-19-0525;

Peerzade SAMA, Qin X, Laroche FJF, Palantavida S, Dokukin M, Peng B, Feng H, Sokolov I. Ultrabright fluorescent silica nanoparticles for in vivo targeting of xenografted human tumors and cancer cells in zebrafish. Nanoscale. 2019 Nov 28; 11(46):22316-22327. PMID: 31724677; PMCID: PMC7384872; DOI: 10.1039/c9nr06371d;

Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX. Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019 Oct 29; 29(5):1287-1298.e6. PMID: 31665640; PMCID: PMC6886125; DOI: 10.1016/j.celrep.2019.09.056;

Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem. 2019 Dec 06; 294(49):18674-18684. PMID: 31659118; PMCID: PMC6901317; DOI: 10.1074/jbc.RA119.010447;

Peng B, Almeqdadi M, Laroche F, Palantavida S, Dokukin M, Roper J, Yilmaz OH, Feng H, Sokolov I. Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Mater Today (Kidlington). 2019 Mar; 23:16-25. PMID: 31057328; PMCID: PMC6497176; DOI: 10.1016/j.mattod.2018.11.001;

Peng B, Almeqdadi M, Laroche F, Palantavida S, Dokukin M, Roper J, Yilmaz OH, Feng H, Sokolov I. Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Data Brief. 2019 Feb; 22:383-391. PMID: 30596135; PMCID: PMC6307339; DOI: 10.1016/j.dib.2018.12.030;

Su H, Hu J, Huang L, Yang Y, Thenoz M, Kuchmiy A, Hu Y, Li P, Feng H, Zhou Y, Taghon T, Van Vlierberghe P, Qing G, Chen Z, Liu H. SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival. Nat Commun. 2018 10 15; 9(1):4281. PMID: 30323192; PMCID: PMC6189109; DOI: 10.1038/s41467-018-06523-4;

Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54.View Related Profiles.

Belkina, Anna
Feng, Hui
Snyder-Cappione , Jennifer
Bais, Manish
Kukuruzinska, Maria
Monti, Stefano
Varelas, Xaralabos

PMID: 30029671; PMCID: PMC6053793; DOI: 10.1186/s13073-018-0569-7;

Narasimhan S, Stanford Zulick E, Novikov O, Parks AJ, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Int J Mol Sci. 2018 May 07; 19(5).View Related Profiles.

Sherr, David
Feng, Hui
Schlezinger, Jennifer
Novikov, Olga
Monti, Stefano
Wang, Zhongyan

PMID: 29735912; PMCID: PMC5983651; DOI: 10.3390/ijms19051388;

Huiting LN, Samaha Y, Zhang GL, Roderick JE, Li B, Anderson NM, Wang YW, Wang L, Laroche F, Choi JW, Liu CT, Kelliher MA, Feng H. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia. 2018 11; 32(11):2339-2351.View Related Profiles.

Feng, Hui
Huiting, Leah

PMID: 29743725; PMCID: PMC6202254; DOI: 10.1038/s41375-018-0141-x;

Anderson NM, Mucka P, Kern JG, Feng H. The emerging role and targetability of the TCA cycle in cancer metabolism. Protein Cell. 2018 02; 9(2):216-237.View Related Profiles.

Feng, Hui
Kern, Joseph
Mucka, Patrick

PMID: 28748451; PMCID: PMC5818369; DOI: 10.1007/s13238-017-0451-1;

Liu X, Li YS, Shinton SA, Rhodes J, Tang L, Feng H, Jette CA, Look AT, Hayakawa K, Hardy RR. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017 09 01; 199(5):1706-1715. PMID: 28739882; PMCID: PMC5563169; DOI: 10.4049/jimmunol.1700552;

Liau WS, Tan SH, Ngoc PCT, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T. Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia. 2017 08; 31(8):1798-1807. PMID: 28028313; PMCID: PMC5529293; DOI: 10.1038/leu.2016.392;

Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H. CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica. 2017 01; 102(1):e17-e21.View Related Profiles.

Landesman, Esther
Feng, Hui

PMID: 27758824; PMCID: PMC5210253; DOI: 10.3324/haematol.2016.154013;

Anderson NM, Li D, Peng HL, Laroche FJ, Mansour MR, Gjini E, Aioub M, Helman DJ, Roderick JE, Cheng T, Harrold I, Samaha Y, Meng L, Amsterdam A, Neuberg DS, Denton TT, Sanda T, Kelliher MA, Singh A, Look AT, Feng H. The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 2016 Jun; 30(6):1365-74.View Related Profiles.

Singh, Anurag
Feng, Hui
Meng, Le

PMID: 26876595; PMCID: PMC4889531; DOI: 10.1038/leu.2016.26;

Harrold I, Carbonneau S, Moore BM, Nguyen G, Anderson NM, Saini AS, Kanki JP, Jette CA, Feng H. Efficient transgenesis mediated by pigmentation rescue in zebrafish. Biotechniques. 2016 Jan; 60(1):13-20. PMID: 26757807; PMCID: PMC4768720; DOI: 10.2144/000114368;

Harrison NR, Laroche FJ, Gutierrez A, Feng H. Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Adv Exp Med Biol. 2016; 916:335-69.View Related Profiles.

Feng, Hui
Harrison, Nicholas

PMID: 27165361; PMCID: PMC4933302; DOI: 10.1007/978-3-319-30654-4_15;

Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62.View Related Profiles.

Costello, Catherine
Feng, Hui
Mehta, Manisha
Rahimi, Nader
Chitalia, Vipul

PMID: 26059764; PMCID: PMC4600037; DOI: 10.1007/s10456-015-9468-3;

Huiting LN, Laroche F, Feng H. The Zebrafish as a Tool to Cancer Drug Discovery. Austin J Pharmacol Ther. 2015; 3(2):1069.View Related Profiles.

Feng, Hui
Huiting, Leah

PMID: 26835511; PMCID: PMC4731041

Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. The c-Cbl ubiquitin ligase regulates nuclear ß-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. J Biol Chem. 2015 May 15; 290(20):12537-46.View Related Profiles.

Feng, Hui
Francis, Jean
Rahimi, Nader
Chitalia, Vipul

PMID: 25784557; PMCID: PMC4432275; DOI: 10.1074/jbc.M114.616623;

Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT. Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol. 2014 Jul; 166(1):84-90. PMID: 24690081; PMCID: PMC4234197; DOI: 10.1111/bjh.12851;

Anderson NM, Harrold I, Mansour MR, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look AT, Feng H. BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. Leukemia. 2014 May; 28(5):1145-8. PMID: 24342948; PMCID: PMC4013222; DOI: 10.1038/leu.2013.377;

Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM. Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 2012 Sep; 26(9):2069-78. PMID: 22538478; PMCID: PMC3435461; DOI: 10.1038/leu.2012.116;

Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, Rodig SJ, Neuberg DS, Helman D, Feng H, Stewart RA, Wang W, George RE, Kanki JP, Look AT. Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell. 2012 Mar 20; 21(3):362-73. PMID: 22439933; PMCID: PMC3315700; DOI: 10.1016/j.ccr.2012.02.010;

Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med. 2011 Aug 1; 208(8):1595-603. PMID: 21727187; PMCID: PMC3149218; DOI: 10.1084/jem.20101691;

Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. PMID: 20951945; PMCID: PMC3003429; DOI: 10.1016/j.ccr.2010.09.009;

Bosu DR, Feng H, Min K, Kim Y, Wallenfang MR, Kipreos ET. C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues. Dev Biol. 2010 Oct 1; 346(1):113-26. PMID: 20659444; PMCID: PMC2955628; DOI: 10.1016/j.ydbio.2010.07.020;

Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C. Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb; 48(2):155-70. PMID: 18973135; PMCID: PMC2605212; DOI: 10.1002/gcc.20623;

Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT. Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol. 2007 Jul; 138(2):169-75. PMID: 17593023

Kim J, Feng H, Kipreos ET. C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Curr Biol. 2007 Jun 5; 17(11):966-72. PMID: 17509881; PMCID: PMC1945017; DOI: 10.1016/j.cub.2007.04.055;

Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6068-73. PMID: 15827121; PMCID: PMC1087915; DOI: 10.1073/pnas.0408708102;

Feng H, Kipreos ET. Preventing DNA re-replication--divergent safeguards in yeast and metazoa. Cell Cycle. 2003 Sep-Oct; 2(5):431-4. PMID: 12963835

Zhong W, Feng H, Santiago FE, Kipreos ET. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature. 2003 Jun 19; 423(6942):885-9. PMID: 12815436

Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt EK, Kipreos ET. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat Cell Biol. 1999 Dec; 1(8):486-92. PMID: 10587644

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 51 publications over 20 distinct years, with a maximum of 6 publications in 2018 and 2020 and 2021

Bar chart showing 51 publications over 20 distinct years, with a maximum of 6 publications in 2018 and 2020 and 2021

Year	Publications
1999	1
2003	2
2005	1
2007	2
2009	1
2010	2
2011	1
2012	2
2013	1
2014	1
2015	3
2016	5
2017	2
2018	6
2019	3
2020	6
2021	6
2022	2
2023	1
2024	3

Media Mentions

Potential Target to Enhance Neuroblastoma Immunotherapy Found

Inside Precision Medicine 3/20/2024

Triple-Negative Breast Cancer Biomarker A Potential Therapy Target

Health IT Analytics 11/17/2021

New metabolic vulnerabilities of subsets of triple-negative breast cancer discovered

News Medical 11/16/2021

Promotion to Associate Professor for 18 Medical Campus Faculty

BU Today 6/14/2019

2018-2021 American Cancer Society: American Cancer Society Scholar Grant

2014-2017 St. Baldrick's Foundation: St. Baldrick Career Development Award

2013-2014 Karin Grunebaum Cancer Research Foundation: Grunebaum Faculty Fellowship

2013-2016 Boston University: Ralph Edwards Career Development Professorship

2012-2015 National Cancer Institute: Howard Temin Pathway to Independence Award in Cancer Research (R00)

2012-2013 American Cancer Society : American Cancer Society pilot Award

2009-2010 Stahl Family Charitable Foundation: Stahl Family Charitable Foundation Award

2009-2011 National Cancer Institute: Howard Temin Pathway to Independence Award in Cancer Research (K99)

2008 Harvard Partners in Health: Partners in Excellence Award

2005-2005 Cancer Research Institute: Postdoctoral Fellowship Award

2005 American Association for Cancer Research: American Association for Cancer Research Award - declined

2005-2008 Leukemia and Lymphoma Society: Special Fellow Award

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cancer
Cancer Therapeutics
MYC
Tumor Intravasation
Zebrafish

Available to Mentor as: (Review Mentor Role Definitions):