Hui Feng | Profiles RNS

Hui Feng, MD, PhD

Associate Professor

Boston University School of Medicine

Dept of Pharmacology & Experimental Therapeutics

MD, Beijing Medical University
PhD, University of Georgia
MS, Peking Union Medical College

Websites

	Feng Lab website
	Pharmacology & Experimental Therapeutics Faculty
	International meeting speaker
	Cancer Cell paper preview
	Fis'ing for Answers

ORCID : 0000-0003-1318-821X

Cancer Research: Dr. Feng is Director of the Laboratory of Zebrafish Genetics and Cancer Therapeutics. Dr. Feng’s research interests focus on identifying novel genes and pathways that are essential for MYC-related tumor transformation and progression, particularly for T-Lymphoblastic Lymphoma/Leukemia, Neuroblastoma and Breast Cancer. The research strategy of Dr. Feng’s research is to combine the analysis of human cancer cells with the genetic and imaging capacities of the zebrafish system.

Current research areas in Dr. Feng’s laboratory include:
1) To determine the molecular mechanisms underlying tumor cell intravasation and tumor progression.
2) To identify novel genes and pathways that, when mutated, delay the initiation and progression of MYC-related cancers.
3) To test the identified genes’ therapeutic potential in treating MYC-related cancers and to characterize their molecular relevance to MYC.

The long-term goal of Dr. Feng’s research is to discover novel molecular therapies to target critical components of MYC-driven oncogenic pathways, thus providing treatment alternatives that are more specific and less toxic.

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2014-2017 St. Baldrick's Foundation: St. Baldrick Career Development Award

2013-2014 Karin Grunebaum Cancer Research Foundation: Grunebaum Faculty Fellowship

2013-2016 Boston University: Ralph Edwards Career Development Professorship

2012-2015 National Cancer Institute: Howard Temin Pathway to Independence Award in Cancer Research (R00)

2012-2013 American Cancer Society : American Cancer Society pilot Award

2009-2010 Stahl Family Charitable Foundation: Stahl Family Charitable Foundation Award

2009-2011 National Cancer Institute: Howard Temin Pathway to Independence Award in Cancer Research (K99)

2008 Harvard Partners in Health: Partners in Excellence Award

2005-2005 Cancer Research Institute: Postdoctoral Fellowship Award

2005 American Association for Cancer Research: American Association for Cancer Research Award - declined

2005-2008 Leukemia and Lymphoma Society: Special Fellow Award

BU Research

The Role of DLST in Leukemogenesis
08/07/2018 - 07/31/2023 (PI)
NIH/National Cancer Institute
5R01CA215059-02

Regulatory Role and Targetability of UFDI in MYC-drlven Leukemia
01/01/2018 - 12/31/2021 (PI)
American Cancer Society, Inc.

Targeting DLST as a novel therapeutic approach for neuroblastoma
07/01/2018 - 06/30/2019 (PI)
St. Baldrick's Foundation

The Role of DLST in Leukemogenesis
08/15/2017 - 07/31/2018 (PI)
NIH/National Cancer Institute
1R56CA215059-01

Targeting DLST as a novel therapeutic approach for neuroblastoma
07/01/2017 - 06/30/2018 (PI)
St. Baldrick's Foundation

Targeting Elevated S1P1 Signaling as a Novel Therapeutic Approach for Triple-Negative Breast Cancer
07/01/2016 - 06/30/2018 (PI)
The Mary Kay Foundation

Targeting DLST as a Novel Therapeutic Approach for Neuroblastoma
07/01/2014 - 06/30/2017 (PI)
St. Baldrick's Foundation

Dissecting the regulatory role of DLST in MYC-driven Leukemogenesis
07/01/2015 - 12/31/2016 (PI)
Leukemia Research Foundation

Oncorequisite Genes in MYC-mediated Transformation
04/01/2012 - 03/31/2015 (PI)
NIH/National Cancer Institute
5R00CA134743-05

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Qin X, Denton WD, Huiting LN, Smith KS, Feng H. Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity. Crit Rev Biochem Mol Biol. 2020 Jul 07; 1-32.View Related Profiles.

Feng, Hui
Huiting, Leah
Qin, Xiaodan

PMID: 32633575

Qin X, Laroche FFJ, Peerzade SAMA, Lam A, Sokolov I, Feng H. In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish. J Vis Exp. 2020 May 08; (159).View Related Profiles.

Feng, Hui
Qin, Xiaodan

PMID: 32449736

Igwebuike C, Yaglom J, Huiting L, Feng H, Campbell JD, Wang Z, Havasi A, Pimentel D, Sherman MY, Borkan SC. Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell Death Dis. 2020 Apr 03; 11(4):217.View Related Profiles.

Havasi, Andrea
Pimentel, David
Feng, Hui
Campbell, Joshua
Huiting, Leah
Borkan, Steven
Wang, Zhiyong

PMID: 32245975

Wong CK, Lambert AW, Ozturk S, Papageorgis P, Lopez D, Shen N, Sen Z, Abdolmaleky HM, Gyorffy B, Feng H, Thiagalingam S. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Mol Cancer Res. 2020 03; 18(3):414-423.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Lopez, Delia
Feng, Hui
Shen, Ning
Thiagalingam, Sam

PMID: 31932471

Peng B, Almeqdadi M, Laroche F, Palantavida S, Dokukin M, Roper J, Yilmaz OH, Feng H, Sokolov I. Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Data Brief. 2019 Feb; 22:383-391. PMID: 30596135; DOI: 10.1016/j.dib.2018.12.030;

Su H, Hu J, Huang L, Yang Y, Thenoz M, Kuchmiy A, Hu Y, Li P, Feng H, Zhou Y, Taghon T, Van Vlierberghe P, Qing G, Chen Z, Liu H. SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival. Nat Commun. 2018 10 15; 9(1):4281. PMID: 30323192; DOI: 10.1038/s41467-018-06523-4;

Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54.View Related Profiles.

Belkina, Anna
Feng, Hui
Snyder-Cappione , Jennifer
Bais, Manish
Kukuruzinska, Maria
Monti, Stefano
Varelas, Xaralabos

PMID: 30029671

Narasimhan S, Stanford Zulick E, Novikov O, Parks AJ, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Int J Mol Sci. 2018 May 07; 19(5).View Related Profiles.

Sherr, David
Feng, Hui
Schlezinger, Jennifer
Novikov, Olga
Monti, Stefano
Wang, Zhongyan

PMID: 29735912

Huiting LN, Samaha Y, Zhang GL, Roderick JE, Li B, Anderson NM, Wang YW, Wang L, Laroche F, Choi JW, Liu CT, Kelliher MA, Feng H. UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia. 2018 11; 32(11):2339-2351.View Related Profiles.

Feng, Hui
Huiting, Leah

PMID: 29743725; DOI: 10.1038/s41375-018-0141-x;

Anderson NM, Mucka P, Kern JG, Feng H. The emerging role and targetability of the TCA cycle in cancer metabolism. Protein Cell. 2018 02; 9(2):216-237.View Related Profiles.

Feng, Hui
Kern, Joseph
Mucka, Patrick

PMID: 28748451

Showing 10 of 33 results. Show More

Liu X, Li YS, Shinton SA, Rhodes J, Tang L, Feng H, Jette CA, Look AT, Hayakawa K, Hardy RR. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017 09 01; 199(5):1706-1715. PMID: 28739882; DOI: 10.4049/jimmunol.1700552;

Liau WS, Tan SH, Ngoc PCT, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T. Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia. 2017 08; 31(8):1798-1807. PMID: 28028313; DOI: 10.1038/leu.2016.392;

Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H. CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica. 2017 01; 102(1):e17-e21.View Related Profiles.

Landesman, Esther
Feng, Hui

PMID: 27758824; DOI: 10.3324/haematol.2016.154013;

Anderson NM, Li D, Peng HL, Laroche FJ, Mansour MR, Gjini E, Aioub M, Helman DJ, Roderick JE, Cheng T, Harrold I, Samaha Y, Meng L, Amsterdam A, Neuberg DS, Denton TT, Sanda T, Kelliher MA, Singh A, Look AT, Feng H. The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 2016 Jun; 30(6):1365-74.View Related Profiles.

Singh, Anurag
Feng, Hui
Meng, Le

PMID: 26876595; PMCID: PMC4889531; DOI: 10.1038/leu.2016.26;

Harrison NR, Laroche FJ, Gutierrez A, Feng H. Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Adv Exp Med Biol. 2016; 916:335-69.View Related Profiles.

Feng, Hui
Harrison, Nicholas

PMID: 27165361; PMCID: PMC4933302; DOI: 10.1007/978-3-319-30654-4_15;

Harrold I, Carbonneau S, Moore BM, Nguyen G, Anderson NM, Saini AS, Kanki JP, Jette CA, Feng H. Efficient transgenesis mediated by pigmentation rescue in zebrafish. Biotechniques. 2016 Jan; 60(1):13-20. PMID: 26757807; PMCID: PMC4768720; DOI: 10.2144/000114368;

Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62.View Related Profiles.

Costello, Catherine
Feng, Hui
Mehta, Manisha
Rahimi, Nader
Chitalia, Vipul

PMID: 26059764; PMCID: PMC4600037; DOI: 10.1007/s10456-015-9468-3;

Huiting LN, Laroche F, Feng H. The Zebrafish as a Tool to Cancer Drug Discovery. Austin J Pharmacol Ther. 2015; 3(2):1069.View Related Profiles.

Feng, Hui
Huiting, Leah

PMID: 26835511

Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. The c-Cbl ubiquitin ligase regulates nuclear ß-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. J Biol Chem. 2015 May 15; 290(20):12537-46.View Related Profiles.

Feng, Hui
Francis, Jean
Rahimi, Nader
Chitalia, Vipul

PMID: 25784557; PMCID: PMC4432275; DOI: 10.1074/jbc.M114.616623;

Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT. Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol. 2014 Jul; 166(1):84-90. PMID: 24690081; DOI: 10.1111/bjh.12851;

Anderson NM, Harrold I, Mansour MR, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look AT, Feng H. BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. Leukemia. 2014 May; 28(5):1145-8. PMID: 24342948; PMCID: PMC4013222; DOI: 10.1038/leu.2013.377;

Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM. Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 2012 Sep; 26(9):2069-78. PMID: 22538478; PMCID: PMC3435461; DOI: 10.1038/leu.2012.116;

Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, Rodig SJ, Neuberg DS, Helman D, Feng H, Stewart RA, Wang W, George RE, Kanki JP, Look AT. Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell. 2012 Mar 20; 21(3):362-73. PMID: 22439933; PMCID: PMC3315700; DOI: 10.1016/j.ccr.2012.02.010;

Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med. 2011 Aug 1; 208(8):1595-603. PMID: 21727187; PMCID: PMC3149218; DOI: 10.1084/jem.20101691;

Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. PMID: 20951945; PMCID: PMC3003429; DOI: 10.1016/j.ccr.2010.09.009;

Bosu DR, Feng H, Min K, Kim Y, Wallenfang MR, Kipreos ET. C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues. Dev Biol. 2010 Oct 1; 346(1):113-26. PMID: 20659444; PMCID: PMC2955628; DOI: 10.1016/j.ydbio.2010.07.020;

Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C. Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb; 48(2):155-70. PMID: 18973135; PMCID: PMC2605212; DOI: 10.1002/gcc.20623;

Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT. Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol. 2007 Jul; 138(2):169-75. PMID: 17593023

Kim J, Feng H, Kipreos ET. C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Curr Biol. 2007 Jun 5; 17(11):966-72. PMID: 17509881; PMCID: PMC1945017

Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6068-73. PMID: 15827121; PMCID: PMC1087915

Feng H, Kipreos ET. Preventing DNA re-replication--divergent safeguards in yeast and metazoa. Cell Cycle. 2003 Sep-Oct; 2(5):431-4. PMID: 12963835

Zhong W, Feng H, Santiago FE, Kipreos ET. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature. 2003 Jun 19; 423(6942):885-9. PMID: 12815436

Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt EK, Kipreos ET. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat Cell Biol. 1999 Dec; 1(8):486-92. PMID: 10587644

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 15 distinct years, with a maximum of 5 publications in 2016 and 2018

Bar chart showing 33 publications over 15 distinct years, with a maximum of 5 publications in 2016 and 2018

Year	Publications
1999	1
2003	2
2005	1
2007	2
2009	1
2010	2
2011	1
2012	2
2013	1
2014	1
2015	3
2016	5
2017	2
2018	5
2020	4

Media Mentions

Promotion to Associate Professor for 18 Medical Campus Faculty

BU Today 6/14/2019

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cancer
Cancer Therapeutics
MYC
Tumor Intravasation
Zebrafish

Available to Mentor as: (Review Mentor Role Definitions):