Hanni Menn-Josephy, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Nephrology

MD, Technion - Israel Institute of Technology



I am an attending physician in the nephrology section at Boston Medical Center, with a special interest in autoimmune kidney diseases in general and lupus nephritis in particular. As a nephrology fellow at Boston University, I worked under the mentorship of Dr. Ian Rifkin and studied IFN regulating pathways in both lupus mice models, as well as in primary human cells.

Since 2011, in collaboration with Drs. Ramon Bonegio (nephrology), Ian Rifkin (nephrology), Michael York (rheumatology), and Christina Lam (dermatology), I helped establish a multidisciplinary lupus and autoimmunity clinic at the Boston Medical Center, where I currently work and treat patients with lupus nephritis. Since we established the Lupus Program, our center participated in four clinical trials involving lupus patients who are refractory to standard therapies. In 2013 we established an autoimmunity registry of patients and sample repository and we have collected and stored renal biopsy samples, samples for genetic testing, serum and peripheral blood mononuclear cells from patients with lupus nephritis both at times of high disease activity and during remission.

As a physician- scientist my research focus is to conduct translational studies utilizing tissue samples from my clinic patients, with the goal of better understanding of the inflammatory pathways that are responsible for the pathogenesis of lupus and lupus nephritis.
I have a strong commitment to try and identify better therapeutic targets for my patients with lupus and lupus nephritis, since current treatments are non specific, have significant toxicity, and most of the patients do not achieve a complete remission.



Toll-like receptor Induced pathways in lupus nephritis
07/01/2016 - 12/31/2017 (PI)
National Kidney Fdtn



Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Bonegio RG, Lin JD, Beaudette-Zlatanova B, York MR, Menn-Josephy H, Yasuda K. Lupus-Associated Immune Complexes Activate Human Neutrophils in an Fc?RIIA-Dependent but TLR-Independent Response. J Immunol. 2019 Feb 01; 202(3):675-683.View Related Profiles. PMID: 30610165.
     
  2. Menn-Josephy H, Lee CS, Nolin A, Christov M, Rybin DV, Weinberg JM, Henderson J, Bonegio R, Havasi A. Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient Cohorts. Am J Nephrol. 2016; 44(4):289-299.View Related Profiles. PMID: 27626625.
     
  3. Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57.View Related Profiles. PMID: 26315890; PMCID: PMC4661118; DOI: 10.1002/art.39321;.
     
  4. Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR. IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol. 2015 Feb 15; 194(4):1467-79.View Related Profiles. PMID: 25595782; PMCID: PMC4323680; DOI: 10.4049/jimmunol.1402807;.
     
  5. Menn-Josephy H, Beck LH. Recurrent glomerular disease in the kidney allograft. Front Biosci (Elite Ed). 2015; 7:135-48.View Related Profiles. PMID: 25553369.
     
  6. Toth-Manikowski SM, Menn-Josephy H, Bhatia J. A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements. Case Rep Nephrol. 2014; 2014:128145.View Related Profiles. PMID: 25215251; DOI: 10.1155/2014/128145;.
     
  7. Waisman D, Brod V, Rahat MA, Amit-Cohen BC, Lahat N, Rimar D, Menn-Josephy H, David M, Lavon O, Cavari Y, Bitterman H. Dose-related effects of hyperoxia on the lung inflammatory response in septic rats. Shock. 2012 Jan; 37(1):95-102. PMID: 21921827; DOI: 10.1097/SHK.0b013e3182356fc3;.
     
  8. Parker J, Menn-Josephy H, Laskow B, Takemura Y, Aprahamian T. Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models. J Clin Immunol. 2011 Apr; 31(2):167-73.View Related Profiles. PMID: 21063900; PMCID: PMC3505060; DOI: 10.1007/s10875-010-9486-2;.
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 3 publications in 2015

YearPublications
20101
20121
20141
20153
20161
20191
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Avoiding toxicity of immunosuppression
Lupus
Lupus nephritis
Mechanisms of autoimmune kidney disease
Mechanisms of autoimmunity
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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