Gina Peloso, PhD
Associate Professor
Boston University School of Public Health
Biostatistics

PhD, Boston University
MA, Boston University
BA, Boston University



Gina Peloso, PhD, is an Associate Professor in the Department of Biostatistics. Prior to joining BU, she was a post-doctoral fellow in Human Genetics at Massachusetts General Hospital and the Broad Institute. Her primary research focus is statistical genetics. She has contributed to the identification of common genetic variants through genome-wide association studies (GWAS) with complex cardiovascular traits, particularly with plasma lipid levels. She also investigates the role of rare genetic variation using both exome and whole genome sequencing. Her goals for studying genetic variation of blood lipid levels include, first, making insights into the biology behind the traits: What are the underlying causes of high/low lipid levels? Second, to use genetic variants to answer clinically meaningful questions: Can we use genetic variants to predict risk?: Does genetics point to potential therapeutic targets? Finally, to make connections between diseases by shared genetic contributions: What is the relationship between the genetics of blood lipid levels and Alzheimer’s disease (AD)? Gina is an active member in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and TOPMed Program, and a lead investigator in the Global Lipid Genetic Consortium (http://lipidgenetics.org/).

Investigator
Framingham Heart Study


Member
Boston University
Genome Science Institute




Using genetic variation to study biology of blood lipids & coronary heart disease
08/01/2021 - 06/30/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
3R01HL127564-07S1

Whole genome sequences in ethically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids
05/01/2019 - 04/30/2024 (Multi-PI)
PI: Gina Peloso, PhD
Massachusetts General Hospital NIH NHLBI
5R01HL142711-04

Combining experiments of man and nature to target human insulin resistance
02/10/2020 - 12/31/2023 (Subcontract PI)
University of California, San Diego NIH NIDDK
5R01DK123422-03

Personnel Agreement for Research Services of Gina Peloso
10/01/2020 - 09/30/2021 (PI)
VA Boston Healthcare System


Contract to support the Division of Population Health and Data Science at the Massachusetts Veterans Epidemiology Research and Informatics Center (MAVERIC)
09/30/2020 - 09/29/2021 (PI of Sub-Project / SP)
PI: David R. Gagnon, MD, PhD
VA Boston Healthcare System


Genetic determinants of triglyceride-rich lipoproteins to disentangle CHD risk
04/15/2018 - 02/28/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R03HL141439-02

Discovering lipoprotein lipase pathway variants that protect against CHD
02/20/2016 - 11/30/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
5K01HL125751-04



Title


Yr Title Project-Sub Proj Pubs
2023 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-05
2023 Using genetic variation to study biology of blood lipids & coronary heart disease 5R01HL127564-07
2023 Using genetic variation to study biology of blood lipids & coronary heart disease 3R01HL127564-07S1
2022 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-04
2022 Using genetic variation to study biology of blood lipids & coronary heart disease 5R01HL127564-06
2021 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-03 14
2021 Using genetic variation to study biology of blood lipids & coronary heart disease 2R01HL127564-05A1 52
2020 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-02 14
2019 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 1R01HL142711-01A1 14
2019 Genetic determinants of triglyceride-rich lipoproteins to disentangle CHD risk 5R03HL141439-02
Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Small AM, Melloni GEM, Kamanu FK, Bergmark BA, Bonaca MP, O'Donoghue ML, Giugliano RP, Scirica BM, Bhatt D, Antman EM, Raz I, Wiviott SD, Truong B, Wilson PWF, Cho K, O'Donnell CJ, Braunwald E, Lubitz SA, Ellinor P, Peloso GM, Ruff CT, Sabatine MS, Natarajan P, Marston NA. Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis. JAMA Cardiol. 2024 Apr 01; 9(4):357-366.View Related Profiles. PMID: 38416462; PMCID: PMC10902779; DOI: 10.1001/jamacardio.2024.0011;
     
  2. Small AM, Pournamdari A, Melloni GEM, Scirica BM, Bhatt DL, Raz I, Braunwald E, Giugliano RP, Sabatine MS, Peloso GM, Marston NA, Natarajan P. Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations. JAMA Cardiol. 2024 Apr 01; 9(4):385-391. PMID: 38353970; PMCID: PMC10867772; DOI: 10.1001/jamacardio.2023.5605;
     
  3. Wang Y, Sarnowski C, Lin H, Pitsillides AN, Heard-Costa NL, Choi SH, Wang D, Bis JC, Blue EE, Boerwinkle E, De Jager PL, Fornage M, Wijsman EM, Seshadri S, Dupuis J, Peloso GM, DeStefano AL. Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data. Alzheimers Dement. 2024 May; 20(5):3290-3304.View Related Profiles. PMID: 38511601
     
  4. Wang B, Dron JS, Wang Y, Choi SH, Huffman JE, Cho K, Wilson PWF, Natarajan P, Peloso GM. Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization. Sci Rep. 2024 Mar 15; 14(1):6267.View Related Profiles. PMID: 38491158; PMCID: PMC10942988; DOI: 10.1038/s41598-024-56946-x;
     
  5. Zhang Y, Dron JS, Bellows BK, Khera AV, Liu J, Balte PP, Oelsner EC, Amr SS, Lebo MS, Nagy A, Peloso GM, Natarajan P, Rotter JI, Willer C, Boerwinkle E, Ballantyne CM, Lutsey PL, Fornage M, Lloyd-Jones DM, Hou L, Psaty BM, Bis JC, Floyd JS, Vasan RS, Heard-Costa NL, Carson AP, Hall ME, Rich SS, Guo X, Kazi DS, de Ferranti SD, Moran AE. Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol. JAMA Cardiol. 2024 Mar 01; 9(3):263-271.View Related Profiles. PMID: 38294787; PMCID: PMC10831623; DOI: 10.1001/jamacardio.2023.5366;
     
  6. Elmore A, Adhikari N, Hartley AE, Javier Aparicio H, Posner DC, Hemani G, Tilling K, Gaunt TR, Wilson P, Casas JP, Michael Gaziano J, Smith GD, Paternoster L, Cho K, Peloso GM. Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank. medRxiv. 2024 Feb 01.View Related Profiles. PMID: 38352469; PMCID: PMC10863017; DOI: 10.1101/2024.01.31.24302111;
     
  7. Trinh MN, Pournamdari A, Small AM, Peloso GM, Patel AP, Natarajan P. Lipoprotein(a) Concentrations Are Independent of Polygenic Score for Coronary Artery Disease. JACC Adv. 2024 Feb; 3(2). PMID: 38549680; PMCID: PMC10976861; DOI: 10.1016/j.jacadv.2023.100800;
     
  8. Urbut SM, Cho SMJ, Paruchuri K, Truong B, Haidermota S, Peloso G, Hornsby W, Philippakis A, Fahed AC, Natarajan P. Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. medRxiv. 2023 Nov 04. PMID: 37961553; PMCID: PMC10635271; DOI: 10.1101/2023.11.03.23298055;
     
  9. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly T, Konigsberg I, Kooperberg C, Kral BG, Li C, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari H, Vasan RS, Wang Z, Yanek LR, Yu B, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies. bioRxiv. 2023 Nov 02.View Related Profiles. PMID: 37961350; PMCID: PMC10634938; DOI: 10.1101/2023.10.30.564764;
     
  10. Jowell AR, Bhattacharya R, Marnell C, Wong M, Haidermota S, Trinder M, Fahed AC, Peloso GM, Honigberg MC, Natarajan P. Genetic and clinical factors underlying a self-reported family history of heart disease. Eur J Prev Cardiol. 2023 Oct 26; 30(15):1571-1579. PMID: 37011137; PMCID: PMC10545808; DOI: 10.1093/eurjpc/zwad096;
     
Showing 10 of 157 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 157 publications over 18 distinct years, with a maximum of 19 publications in 2016 and 2023

YearPublications
20071
20081
20095
20105
20113
20127
201310
20148
20157
201619
201710
201813
20194
20209
202112
202218
202319
20246

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Risk Factors
Biostatistics
Human Genetics
Statistical Genetics
Statistical Data Analyses
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801 Massachusetts Ave Crosstown Center
Boston MA 02118
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