Gina Peloso, PhD
Associate Professor
Boston University School of Public Health
Biostatistics

PhD, Boston University
MA, Boston University
BA, Boston University



Gina Peloso, PhD, is an Associate Professor in the Department of Biostatistics. Prior to joining BU, she was a post-doctoral fellow in Human Genetics at Massachusetts General Hospital and the Broad Institute. Her primary research focus is statistical genetics. She has contributed to the identification of common genetic variants through genome-wide association studies (GWAS) with complex cardiovascular traits, particularly with plasma lipid levels. She also investigates the role of rare genetic variation using both exome and whole genome sequencing. Her goals for studying genetic variation of blood lipid levels include, first, making insights into the biology behind the traits: What are the underlying causes of high/low lipid levels? Second, to use genetic variants to answer clinically meaningful questions: Can we use genetic variants to predict risk?: Does genetics point to potential therapeutic targets? Finally, to make connections between diseases by shared genetic contributions: What is the relationship between the genetics of blood lipid levels and Alzheimer’s disease (AD)? Gina is an active member in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and TOPMed Program, and a lead investigator in the Global Lipid Genetic Consortium (http://lipidgenetics.org/).

Investigator
Framingham Heart Study


Member
Boston University
Genome Science Institute




Using genetic variation to study biology of blood lipids & coronary heart disease
08/01/2021 - 06/30/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
3R01HL127564-07S1

Whole genome sequences in ethically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids
05/01/2019 - 04/30/2024 (Multi-PI)
PI: Gina Peloso, PhD
Massachusetts General Hospital NIH NHLBI
5R01HL142711-04

Combining experiments of man and nature to target human insulin resistance
02/10/2020 - 12/31/2023 (Subcontract PI)
University of California, San Diego NIH NIDDK
5R01DK123422-03

Personnel Agreement for Research Services of Gina Peloso
10/01/2020 - 09/30/2021 (PI)
VA Boston Healthcare System


Contract to support the Division of Population Health and Data Science at the Massachusetts Veterans Epidemiology Research and Informatics Center (MAVERIC)
09/30/2020 - 09/29/2021 (PI of Sub-Project / SP)
PI: David R. Gagnon, MD, PhD
VA Boston Healthcare System


Genetic determinants of triglyceride-rich lipoproteins to disentangle CHD risk
04/15/2018 - 02/28/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R03HL141439-02

Discovering lipoprotein lipase pathway variants that protect against CHD
02/20/2016 - 11/30/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
5K01HL125751-04



Title


Yr Title Project-Sub Proj Pubs
2023 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-05
2023 Using genetic variation to study biology of blood lipids & coronary heart disease 5R01HL127564-07
2023 Using genetic variation to study biology of blood lipids & coronary heart disease 3R01HL127564-07S1
2022 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-04
2022 Using genetic variation to study biology of blood lipids & coronary heart disease 5R01HL127564-06
2021 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-03 14
2021 Using genetic variation to study biology of blood lipids & coronary heart disease 2R01HL127564-05A1 52
2020 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 5R01HL142711-02 14
2019 Whole genome sequences in ethnically diverse individuals with functional assays and genome editing to characterize the biology of plasma lipids 1R01HL142711-01A1 14
2019 Genetic determinants of triglyceride-rich lipoproteins to disentangle CHD risk 5R03HL141439-02
Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O'Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W, Rotter JI, Lin X, Natarajan P, Peloso GM. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study. Am J Hum Genet. 2023 Oct 05; 110(10):1704-1717.View Related Profiles. PMID: 37802043
     
  2. Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P. Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. J Clin Invest. 2023 Sep 15; 133(18).View Related Profiles. PMID: 37498674; PMCID: PMC10503804; DOI: 10.1172/JCI168597;
     
  3. Urbut SM, Koyama S, Hornsby W, Bhukar R, Kheterpal S, Truong B, Selvaraj MS, Neale B, O'Donnell CJ, Peloso GM, Natarajan P. Bayesian multivariate genetic analysis improves translational insights. iScience. 2023 Oct 20; 26(10):107854.View Related Profiles. PMID: 37766997; PMCID: PMC10520309; DOI: 10.1016/j.isci.2023.107854;
     
  4. Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project. medRxiv. 2023 Sep 02.View Related Profiles. PMID: 37693521; PMCID: PMC10491367; DOI: 10.1101/2023.09.01.23294953;
     
  5. Wang Y, Sarnowski C, Lin H, Pitsillides AN, Heard-Costa NL, Choi SH, Wang D, Bis JC, Blue EE, Boerwinkle E, De Jager PL, Fornage M, Wijsman EM, Seshadri S, Dupuis J, Peloso GM, DeStefano AL. Key variants via Alzheimer's Disease Sequencing Project whole genome sequence data. medRxiv. 2023 Aug 29.View Related Profiles. PMID: 37693453; PMCID: PMC10491364; DOI: 10.1101/2023.08.28.23294631;
     
  6. Zhang D, Gao B, Feng Q, Manichaikul A, Peloso GM, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Gabriel S, Gupta N, Smith JD, Aguet F, Ardlie KG, Blackwell TW, Gerszten RE, Rich SS, Rotter JI, Scott LJ, Zhou X, Lee S. Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies. bioRxiv. 2023 Aug 21. PMID: 37662416; PMCID: PMC10473643; DOI: 10.1101/2023.08.17.553749;
     
  7. Keshawarz A, Bui H, Joehanes R, Ma J, Liu C, Huan T, Hwang SJ, Tejada B, Sooda M, Courchesne P, Munson PJ, Demirkale CY, Yao C, Heard-Costa NL, Pitsillides AN, Lin H, Liu CT, Wang Y, Peloso GM, Lundin J, Haessler J, Du Z, Cho M, Hersh CP, Castaldi P, Raffield LM, Wen J, Li Y, Reiner AP, Feolo M, Sharopova N, Vasan RS, DeMeo DL, Carson AP, Kooperberg C, Levy D. Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study. Sci Rep. 2023 Aug 10; 13(1):12952.View Related Profiles. PMID: 37563237; PMCID: PMC10415314; DOI: 10.1038/s41598-023-39936-3;
     
  8. Tessler I, Albuisson J, Piñeiro-Sabarís R, Verstraeten A, Kamber Kaya HE, Siguero-Álvarez M, Goudot G, MacGrogan D, Luyckx I, Shpitzen S, Levin G, Kelman G, Reshef N, Mananet H, Holdcraft J, Muehlschlegel JD, Peloso GM, Oppenheim O, Cheng C, Mazzella JM, Andelfinger G, Mital S, Eriksson P, Billon C, Heydarpour M, Dietz HC, Jeunemaitre X, Leitersdorf E, Sprinzak D, Blacklow SC, Body SC, Carmi S, Loeys B, de la Pompa JL, Gilon D, Messas E, Durst R. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. JAMA Cardiol. 2023 Aug 01; 8(8):721-731.View Related Profiles. PMID: 37405741; PMCID: PMC10323766; DOI: 10.1001/jamacardio.2023.1469;
     
  9. Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR, Pietzner M, Farber-Eger EH, Wells QS, Kosik NM, Gaziano L, Posner DC, Bento AP, Hui Q, Liu C, Aragam K, Wang Z, Charest B, Huffman JE, Wilson PWF, Phillips LS, Whittaker J, Munroe PB, Petersen SE, Cho K, Leach AR, Magariños MP, Gaziano JM, Langenberg C, Sun YV, Joseph J, Casas JP. Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure. Nat Commun. 2023 Jul 10; 14(1):3826.View Related Profiles. PMID: 37429843; PMCID: PMC10333277; DOI: 10.1038/s41467-023-39253-3;
     
  10. Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O'Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W, Rotter JI, Lin X, Natarajan P, Peloso GM. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study. medRxiv. 2023 Jun 29.View Related Profiles. PMID: 37425772; PMCID: PMC10327287; DOI: 10.1101/2023.06.28.23291966;
     
Showing 10 of 149 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 149 publications over 17 distinct years, with a maximum of 19 publications in 2016

YearPublications
20071
20081
20095
20105
20113
20127
201310
20148
20157
201619
201710
201813
20194
20209
202112
202218
202317

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Risk Factors
Biostatistics
Human Genetics
Statistical Genetics
Statistical Data Analyses
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801 Massachusetts Ave Crosstown Center
Boston MA 02118
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