Frederic Little | Profiles RNS

Frederic F. Little, MD

Clinical Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Tufts University School of Medicine
AB, Harvard College

Websites

	Pulmonary, Allergy, Sleep & Critical Care Medicine Faculty
	Boston Medical Center Provider Profile

ORCID : 0000-0003-4342-7007

Dr. Little is an Assistant Professor in the Department of Medicine. He attends on the Allergy Consultation Service as well as the Medical Intensive Care Unit and Pulmonary Consultation Service at Boston Medical Center . His outpatient activity is concentrated in the Adult Asthma and Allergy Clinics.

Dr. Little’s longstanding clinical interests and research efforts are focused on examining the nature of airway inflammation in allergic asthma, and translational approaches to diagnostics of allergic disease.

Prior to coming to Boston University, during a postdoctoral fellowship at the UCSF Cardiovascular Research Institute , he investigated the effect of causing an experimental cold in asthmatic and healthy volunteers, followed by concurrent examination of clinical asthma markers (e.g., spirometry, symptoms) and airway secretions by nasal lavage and sputum induction.

In the laboratory, he used key cytokine transgenic and knockout mice to investigate antigen-dependent and -independent allergic airway inflammation. Specifically, he investigated interleukin-16, a major CD4 ligand, as a paradigm for downregulation of antigen-dependent TH2 inflammation.

His translational research continues at Boston University as a principle investigator in a clinic-based study to develop a rapid saliva diagnostics platform for determining the causes of deterioration in asthma control. This study has expanded to both Emergency Room populations at B.U. and cohorts of pediatric asthmatics in collaboration Dr. Elizabeth Matsui, Pediatric Allergy/Immunology at Johns Hopkins. This translational approach has also been used in developing a point of care device to accurately and rapidly quantify allergen-specific IgE using component-resolved diagnostics. This latter ongoing effort is in collaboration with Drs. M. Selim Unlü in the Boston University College of Engineering.

He has also participated as a Co-Investigator in immunotherapy trials with the NHLBI-funded Inner City Asthma Consortium, in collaboration with the BUMC site PI, Dr. George O’Connor.

Dr. Little’s educational and administrative responsibilities include directing the Boston University Allergy/Immunology Fellowship Training Program and being the Medical Director of the Pulmonary, Allergy and Sleep Clinics. He is also the Clinical Director of Allergy at Boston Medical Center, a role that touches on care delivery in the inpatient and outpatient settings.

Research interests include:
-Pulmonary Immunology
-Salivary Diagnostics of Lung Disease
-Point of Care Diagnostics of Allergic Disease

Clinical interests include:
-Asthma/Allergy
-Critical Care Medicine
-Eosinophilic Disorders

Member
Boston University
Pulmonary Center

Multiplexed, Rapid, Point of Care Device to Quantify Specific IgE to Common Allergens
08/01/2011 - 07/31/2015 (Key Person)
PI: Selim Ünlü, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
5R21EB015900-03

Multiplexed, Rapid, Point of Care Device to Quantify Specific IgE to Common Allergens
08/01/2011 - 07/31/2014 (Key Person)
PI: Selim Ünlü, PhD
NIH/National Center for Health Research Resources
1R21RR032378-01

Rapid Disposable Microchip for Complete Blood Count
07/01/2012 - 06/30/2014 (Co-Investigator)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIBIB
5U54EB015408-02

Effect of IL-16 on the Murine Allergic Airway Response
07/01/2003 - 06/30/2009 (PI)
NIH/National Heart, Lung, and Blood Institute
5 K08 HL71607 05

The Role of Airway Epithelial Expression of IL-16 in Th2-mediated Lung Inflammation
07/01/2002 - 06/30/2005 (PI)
Parker B. Francis Foundation

Microsensor Arrays for Salivary Diagnostics
09/01/2006 - 02/28/2013 (PI)
Tufts University NIH-NIDCR

Title

Yr	Title	Project-Sub Proj	Pubs
2007	Effect of IL-16 on the Murine Allergic Airway Response	5K08HL071607-05	1
2006	Effect of IL-16 on the Murine Allergic Airway Response	5K08HL071607-04	1
2005	Effect of IL-16 on the Murine Allergic Airway Response	5K08HL071607-03	1
2004	Effect of IL-16 on the Murine Allergic Airway Response	5K08HL071607-02	1
2003	Effect of IL-16 on the Murine Allergic Airway Response	1K08HL071607-01	1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Kearney L, Wiener RS, Dahodwala M, Fix GM, Hicks J, Little F, Howard J, Foreman AG, Wakeman C, O'Donnell C, Bulekova K, Drainoni ML, Kathuria H. A mixed methods study to inform and evaluate a longitudinal nurse practitioner/community health worker intervention to address social determinants of health and chronic obstructive pulmonary disease self-management. BMC Pulm Med. 2022 Mar 01; 22(1):74.View Related Profiles.

Wakeman, Cornelia
Little, Frederic
Fix, Gemmae
Kathuria, Hasmeena
Hicks, Jacqueline
Bulekova, Katia
Bulekova, Katia
Kearney, Lauren
Drainoni, Mari-Lynn
Wiener, Renda

PMID: 35232414; PMCID: PMC8889692; DOI: 10.1186/s12890-022-01863-w;

Risma KA, Edwards KM, Hummell DS, Little FF, Norton AE, Stallings A, Wood RA, Milner JD. Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines. J Allergy Clin Immunol. 2021 06; 147(6):2075-2082.e2. PMID: 33857566; PMCID: PMC8056854; DOI: 10.1016/j.jaci.2021.04.002;

Sheehan WJ, Krouse RZ, Calatroni A, Gergen PJ, Gern JE, Gill MA, Gruchalla RS, Khurana Hershey GK, Kattan M, Kercsmar CM, Lamm CI, Little FF, Makhija MM, Searing DA, Zoratti E, Busse WW, Teach SJ. Aeroallergen Sensitization, Serum IgE, and Eosinophilia as Predictors of Response to Omalizumab Therapy During the Fall Season Among Children with Persistent Asthma. J Allergy Clin Immunol Pract. 2020 10; 8(9):3021-3028.e2. PMID: 32376491; PMCID: PMC8775809; DOI: 10.1016/j.jaip.2020.03.051;

Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2014 Nov; 124(11):5085.View Related Profiles.

Center, David
Little, Frederic
Cruikshank, William

PMID: 25365075; PMCID: PMC4347257; DOI: 10.1172/JCI79199;

Reddy D, Little FF. Glucocorticoid-resistant asthma: more than meets the eye. J Asthma. 2013 Dec; 50(10):1036-44. PMID: 23923995; DOI: 10.3109/02770903.2013.831870;

Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012 Jan 15; 188(2):854-63.View Related Profiles.

Fine, Alan
Little, Frederic
Konter, Jason
Nakamura, Kazuto
Summer, Ross

PMID: 22156343; PMCID: PMC3253176; DOI: 10.4049/jimmunol.1100426;

Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.View Related Profiles.

Center, David
Little, Frederic
Wilson, Kevin
Tuzova, Marina
Cruikshank, William

PMID: 22080865; PMCID: PMC3225985; DOI: 10.1172/JCI41769;

Richmond J, Finkel M, Studwell A, Little F, Cruikshank W. Introduction of pro-interleukin-16 inhibits T-lymphoblastic leukemia growth in mice. J Cancer Res Clin Oncol. 2011 Oct; 137(10):1581-5.View Related Profiles.

Little, Frederic
Cruikshank, William

PMID: 21818556; DOI: 10.1007/s00432-011-1017-x;

Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):287-94.View Related Profiles.

Little, Frederic
Lu, Jining
Qian, Jun
Wu, Junjie
Cushing, Leah
Kuang, Ping-Ping
Cardoso, Wellington

PMID: 20971881; PMCID: PMC3175558; DOI: 10.1165/rcmb.2010-0323OC;

Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Wexler PJ, Little FF, Walt DR. Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem. 2009 Mar 15; 81(6):2106-14.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Little, Frederic

PMID: 19192965; PMCID: PMC2765577; DOI: 10.1021/ac802181j;

Showing 10 of 32 results. Show More

Summer R, Little FF, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1035-42.View Related Profiles.

Fine, Alan
Suki, Bela
Little, Frederic
Walsh, Kenneth
Aprahamian, Tamar

PMID: 18326826; PMCID: PMC3575679; DOI: 10.1152/ajplung.00397.2007;

Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN. Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):133-41.View Related Profiles.

Fine, Alan
Wilson, Andrew
Kotton, Darrell
Little, Frederic

PMID: 18323534; PMCID: PMC2542452; DOI: 10.1165/rcmb.2007-0133OC;

Cruikshank W, Little F. lnterleukin-16: the ins and outs of regulating T-cell activation. Crit Rev Immunol. 2008; 28(6):467-83.View Related Profiles.

Little, Frederic
Cruikshank, William

PMID: 19265505

Walt DR, Blicharz TM, Hayman RB, Rissin DM, Bowden M, Siqueira WL, Helmerhorst EJ, Grand-Pierre N, Oppenheim FG, Bhatia JS, Little FF, Brody JS. Microsensor arrays for saliva diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:389-400.View Related Profiles.

Helmerhorst, Eva
Oppenheim, Frank
Little, Frederic
Bhatia, Jasvinder
Brody, Jerome

PMID: 17435144; PMCID: PMC7168095; DOI: 10.1196/annals.1384.031;

Little FF, Wilson KC, Berman JS, Center DM. Lymphocyte- and macrophage-mediated inflammation in the lung. In: Fishman’s Pulmonary Diseases and Disorders, 4th ed, Fishman A.P. et al, eds. McGraw-Hill. New York. 2007.
Little FF, Hollingsworth HM. Anaphylaxis. In: Intensive Care Medicine, 6th edit. Irwin, R.S and Rippe, J.M., eds. Lippincott Williams & Wilkins. Philadelphia. 2007.

Little FF. Treating acute asthma with antibiotics--not quite yet. N Engl J Med. 2006 Apr 13; 354(15):1632-4. PMID: 16611955

Little FF, Cruikshank WW, Center DM. IL-16. In: Encyclopedia of Respiratory Medicine, Laurent, G.J and Shapiro, S.D., eds. Elsevier. Oxford. 2006.

Burkart KM, Barton SJ, Holloway JW, Yang IA, Cakebread JA, Cruikshank W, Little F, Jin X, Farrer LA, Clough JB, Keith TP, Holgate S, Center DM, O'Connor GT. Association of asthma with a functional promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 2006 Jan; 117(1):86-91.View Related Profiles.

Center, David
Little, Frederic
O'Connor, George
Farrer, Lindsay
Cruikshank, William

PMID: 16387589

Little FF, Cruikshank WW. Interleukin-16 and peptide derivatives as immunomodulatory therapy in allergic lung disease. Expert Opin Biol Ther. 2004 Jun; 4(6):837-46.View Related Profiles.

Little, Frederic
Cruikshank, William

PMID: 15174966

Lynch EL, Little FF, Wilson KC, Center DM, Cruikshank WW. Immunomodulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev. 2003 Dec; 14(6):489-502.View Related Profiles.

Center, David
Little, Frederic
Wilson, Kevin
Cruikshank, William

PMID: 14563351

Little FF, Center DM. Induced sputum analysis for T helper type 2 cell regulation: closing the loop. Chest. 2003 Jun; 123(6):1786-8.View Related Profiles.

Center, David
Little, Frederic

PMID: 12796149

Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S.View Related Profiles.

Center, David
Little, Frederic
Cruikshank, William

PMID: 12629022

Little FF, Lynch E, Fine G, Center DM, Cruikshank WW. Tumor necrosis factor-alpha-induced synthesis of interleukin-16 in airway epithelial cells: priming for serotonin stimulation. Am J Respir Cell Mol Biol. 2003 Mar; 28(3):354-62.View Related Profiles.

Center, David
Little, Frederic
Cruikshank, William

PMID: 12594062

Little FF, Cruikshank WW, Center DM. IL-16 and airway hyperresponsiveness in asthma. In: Biology of Airway Inflammation – Therapeutic Targets, Eissa, N.T., ed. Series: Lung Biology in Health and Disease. Marcel Dekker. New York. 2003; 177.
Little FF, Hollingsworth HM. Anaphylaxis. In: Intensive Care Medicine, 5th edit. Irwin, R.S and Rippe, J.M., eds. Lippincott Williams & Wilkins. Philadelphia. 2003.

De Bie JJ, Jonker EH, Henricks PA, Hoevenaars J, Little FF, Cruikshank WW, Nijkamp FP, Van Oosterhout AJ. Exogenous interleukin-16 inhibits antigen-induced airway hyper-reactivity, eosinophilia and Th2-type cytokine production in mice. Clin Exp Allergy. 2002 Nov; 32(11):1651-8.View Related Profiles.

Little, Frederic
Cruikshank, William

PMID: 12569988

Little FF, Cruikshank WW, Center DM. Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001 Sep; 25(3):347-52.View Related Profiles.

Center, David
Little, Frederic
Cruikshank, William

PMID: 11588013

Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA. Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med. 1999 Jul; 160(1):100-8. PMID: 10390386

Kelsey KT, Wiencke JK, Little FF, Baker EL, Little JB. Sister chromatid exchange in painters recently exposed to solvents. Environ Res. 1989 Dec; 50(2):248-55. PMID: 2583070

Nagasawa H, Burke MJ, Little FF, McCone EF, Chan GL, Little JB. Multiple abnormalities in the ultraviolet light response of cultured fibroblasts derived from patients with the basal cell nevus syndrome. Teratog Carcinog Mutagen. 1988; 8(1):25-33. PMID: 2897722

Kelsey KT, Wiencke JK, Little FF, Baker EL, Little JB. Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters. Environ Mol Mutagen. 1988; 11(3):389-99. PMID: 3356184

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 18 distinct years, with a maximum of 6 publications in 2003