Alpaslan Dedeoglu, MD, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

MD, Istanbul University
PhD, Marmara University



Dr. Alpaslan Dedeoglu received his MD from the Istanbul University School of Medicine and completed a pharmacology program at the Marmara University in 1992. During and after his pharmacology program he worked at the University of Arizona, Ohio State University, and Massachusetts General Hospital; he then joined Boston University in 2000. Dr. Dedeoglu’s major research interests are neuroanatomy, neuropathology, and the neurochemistry of animal models of neurodegenerative disorders. His labs are located at the Boston VA Medical Center. Dr. Dedeoglu is the PI of several ongoing projects that are funded by the NIH, VA, and private foundations. He also works with therapeutic trials in rodent models of neurodegenerative disorders.

VA Boston Healthcare System


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Protective roles of taurine in Alzheimer's Disease brain
09/01/2020 - 08/31/2024 (Multi-PI)
PI: Alpaslan Dedeoglu, MD, PhD
Massachusetts General Hospital NIH NIA
1RF1AG069228-01

Mechanistic link between Alzheimer's disease and periodontitis
07/01/2019 - 03/31/2024 (Multi-PI)
PI: Alpaslan Dedeoglu, MD, PhD
NIH/National Institute on Aging
1RF1AG062496-01

Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease
09/01/2017 - 08/31/2022 (PI)
NIH/National Institute on Aging
1RF1AG056032-01A1

Skeletal FGF23 production mediated by GPCR/Gq/PKC signaling
04/01/2021 - 03/31/2022 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIDDK
3R01DK121776-02S1

XLas Relative to Gsa in Bone and Mineral Ion Metabolism
09/01/2018 - 11/30/2019 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIDDK
3R01DK073911-10S1

Mechanisms of Resolvin E1 in Periodontal Regeneration (admin supplement)
09/01/2018 - 06/30/2019 (Subcontract PI)
Forsyth Institute NIH NIDCR
3R01DE025020-04S1

Personnel Agreement for Research Services of Nurgul Aytan
09/15/2013 - 06/30/2017 (PI)
VA Boston Healthcare System


Fingolimod therapy in models of Alzheimer's disease
02/01/2015 - 08/01/2016 (PI)
Alzheimer's Drug Discovery Foundation


Interpersonnel Agreement for Sudarshana Sengupta
08/15/2014 - 09/14/2015 (PI)
VA Boston Healthcare System


Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
09/15/2009 - 08/31/2015 (PI)
NIH/National Institute on Aging
5R01AG031896-05

Showing 10 of 12 results. Show All Results


Title
Mechanistic Link Between Alzheimer's Disease and Periodontitis
(PI)

Sphingosine-1-phosphate induced modulation of inflammation
(PI)

XLas Relative to GSA in Bone and Mineral Ion Metabolism
(PI)

Mouse Breeding Colonies for Neurodegenerative Diseases
(PI)



Yr Title Project-Sub Proj Pubs
2023 Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis 5I01BX005180-03
2022 Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis 5I01BX005180-02
2021 Sphingosine-1-phosphate system as a therapeutic target for amyotrophic lateral sclerosis 1I01BX005180-01
2021 Targeting the sphingosine-1-phosphate system in a mouse model of Gulf War Veterans' Illness 1I21BX004957-01
2021 Targeting the sphingosine-1-phosphate system in a mouse model of Gulf War Veterans' Illness 5I21BX004957-02
2020 Protective roles of taurine in Alzheimer's disease brain 1RF1AG069228-01
2019 Mechanistic link between Alzheimer's disease and periodontitis 1RF1AG062496-01 1
2017 Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease 1RF1AG056032-01A1 1
2017 Novel neurotrophic therapies in an optimized mouse model of GWVI 5I01BX002468-04 1
2017 Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy 5I01BX001875-04 1
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ay B, Cyr SM, Klovdahl K, Zhou W, Tognoni CM, Iwasaki Y, Rhee EP, Dedeoglu A, Simic P, Bastepe M. Ga11 deficiency increases fibroblast growth factor-23 levels in a mouse model of Familial Hypocalciuric Hypercalcemia. JCI Insight. 2024 Mar 26.View Related Profiles. PMID: 38530370
     
  2. Almarhoumi R, Alvarez C, Harris T, Tognoni CM, Paster BJ, Carreras I, Dedeoglu A, Kantarci A. Microglial cell response to experimental periodontal disease. J Neuroinflammation. 2023 Jun 14; 20(1):142.View Related Profiles. PMID: 37316834; PMCID: PMC10265806; DOI: 10.1186/s12974-023-02821-x;
     
  3. Carreras I, Jung Y, Lopez-Benitez J, Tognoni CM, Dedeoglu A. Fingolimod mitigates memory loss in a mouse model of Gulf War Illness amid decreasing the activation of microglia, protein kinase R, and NF?B. Neurotoxicology. 2023 May; 96:197-206.View Related Profiles. PMID: 37160207; PMCID: PMC10334821; DOI: 10.1016/j.neuro.2023.05.006;
     
  4. Jung Y, Lopez-Benitez J, Tognoni CM, Carreras I, Dedeoglu A. Dysregulation of sphingosine-1-phosphate (S1P) and S1P receptor 1 signaling in the 5xFAD mouse model of Alzheimer's disease. Brain Res. 2023 Jan 15; 1799:148171.View Related Profiles. PMID: 36410428
     
  5. Wu H, Qiu W, Zhu X, Li X, Xie Z, Carreras I, Dedeoglu A, Van Dyke T, Han YW, Karimbux N, Tu Q, Cheng L, Chen J. The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways. Front Aging Neurosci. 2022; 14:912709.View Related Profiles. PMID: 35813949; PMCID: PMC9260256; DOI: 10.3389/fnagi.2022.912709;
     
  6. Ma KS, Hasturk H, Carreras I, Dedeoglu A, Veeravalli JJ, Huang JY, Kantarci A, Wei JC. Dementia and the Risk of Periodontitis: A Population-Based Cohort Study. J Dent Res. 2022 03; 101(3):270-277.View Related Profiles. PMID: 34643147; PMCID: PMC8982009; DOI: 10.1177/00220345211037220;
     
  7. Kantarci A, Tognoni CM, Yaghmoor W, Marghalani A, Stephens D, Ahn JY, Carreras I, Dedeoglu A. Microglial response to experimental periodontitis in a murine model of Alzheimer's disease. Sci Rep. 2020 10 29; 10(1):18561.View Related Profiles. PMID: 33122702; PMCID: PMC7596239; DOI: 10.1038/s41598-020-75517-4;
     
  8. Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A, Huang X. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020 03 06; 10(3).View Related Profiles. PMID: 32155778; PMCID: PMC7175127; DOI: 10.3390/biom10030408;
     
  9. Carreras I, Aytan N, Choi JK, Tognoni CM, Kowall NW, Jenkins BG, Dedeoglu A. Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. Sci Rep. 2019 07 29; 9(1):10972.View Related Profiles. PMID: 31358793; PMCID: PMC6662857; DOI: 10.1038/s41598-019-47287-1;
     
  10. Korkmaz OT, Ay H, Aytan N, Carreras I, Kowall NW, Dedeoglu A, Tuncel N. Vasoactive Intestinal Peptide Decreases ß-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's Disease. J Mol Neurosci. 2019 Jul; 68(3):389-396.View Related Profiles. PMID: 30498985
     
Showing 10 of 57 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 57 publications over 22 distinct years, with a maximum of 9 publications in 2001

YearPublications
20004
20019
20026
20033
20043
20051
20072
20081
20094
20102
20133
20143
20151
20161
20172
20183
20191
20202
20211
20222
20232
20241

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150 S Huntington Avenue
Jamaica Plain MA 02130
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