Alpaslan Dedeoglu, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Neurology

MD, Istanbul University
PhD, Marmara University




Dr. Alpaslan Dedeoglu received his MD from the Istanbul University School of Medicine and completed a pharmacology program at the Marmara University in 1992. During and after his pharmacology program he worked at the University of Arizona, Ohio State University, and Massachusetts General Hospital; he then joined Boston University in 2000. Dr. Dedeoglu’s major research interests are neuroanatomy, neuropathology, and the neurochemistry of animal models of neurodegenerative disorders. His labs are located at the Boston VA Medical Center. Dr. Dedeoglu is the PI of several ongoing projects that are funded by the NIH, VA, and private foundations. He also works with therapeutic trials in rodent models of neurodegenerative disorders.

VA Boston Healthcare System


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Mechanistic link between Alzheimer's disease and periodontitis
07/01/2019 - 04/30/2024 (Multi-PI)
PI: Alpaslan Dedeoglu, MD, PhD
NIH/National Institute on Aging
1RF1AG062496-01

Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease
09/01/2017 - 03/31/2022 (PI)
NIH/National Institute on Aging
1RF1AG056032-01A1

XLas Relative to Gsa in Bone and Mineral Ion Metabolism
09/01/2018 - 11/30/2019 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NIDDK
3R01DK073911-10S1

Mechanisms of Resolvin E1 in Periodontal Regeneration (admin supplement)
09/01/2018 - 06/30/2019 (Subcontract PI)
Forsyth Institute NIH NIDCR
3R01DE025020-04S1

Personnel Agreement for Research Services of Nurgul Aytan
09/15/2013 - 06/30/2017 (PI)
VA Boston Healthcare System


Fingolimod therapy in models of Alzheimer's disease
02/01/2015 - 08/01/2016 (PI)
Alzheimer's Drug Discovery Foundation


Interpersonnel Agreement for Sudarshana Sengupta
08/15/2014 - 09/14/2015 (PI)
VA Boston Healthcare System


Cyclohexanehexol Therapy in Transgenic Models of Alzheimer's Disease
09/15/2009 - 08/31/2015 (PI)
NIH/National Institute on Aging
5R01AG031896-05

Integrated Neuroimaging and Pathology of Alzheimer Mice
08/01/2005 - 07/31/2007 (PI)
NIH/National Institute on Aging
5 R21 AG025162 02

Anti-Inflammatory Therapy in a Mouse Model of Alzheimer’s Disease: A Magnetic Resonance Imaging, Spectroscopy and Quantitative Histopathological Study
08/01/2002 - 07/31/2004 (PI)
Alzheimer's Association



Title
Mechanistic Link Between Alzheimer's Disease and Periodontitis
Sphingosine-1-phosphate induced modulation of inflammation
XLas Relative to GSA in Bone and Mineral Ion Metabolism
Mouse Breeding Colonies for Neurodegenerative Diseases


Yr Title Project-Sub Proj Pubs
2019 Mechanistic link between Alzheimer's disease and periodontitis 1RF1AG062496-01 1
2017 Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease 1RF1AG056032-01A1 1
2017 Novel neurotrophic therapies in an optimized mouse model of GWVI 5I01BX002468-04 1
2017 Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy 5I01BX001875-04 1
2016 Novel neurotrophic therapies in an optimized mouse model of GWVI 5I01BX002468-03 1
2016 Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy 5I01BX001875-03 1
2015 Novel neurotrophic therapies in an optimized mouse model of GWVI 5I01BX002468-02 1
2015 Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy 5I01BX001875-02 1
2014 Novel neurotrophic therapies in an optimized mouse model of GWVI 1I01BX002468-01 1
2014 Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy 1I01BX001875-01A2 1
Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A, Huang X. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020 03 06; 10(3).View Related Profiles. PMID: 32155778
     
  2. Carreras I, Aytan N, Choi JK, Tognoni CM, Kowall NW, Jenkins BG, Dedeoglu A. Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. Sci Rep. 2019 07 29; 9(1):10972.View Related Profiles. PMID: 31358793
     
  3. Korkmaz OT, Ay H, Aytan N, Carreras I, Kowall NW, Dedeoglu A, Tuncel N. Vasoactive Intestinal Peptide Decreases ß-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's Disease. J Mol Neurosci. 2019 Jul; 68(3):389-396.View Related Profiles. PMID: 30498985
     
  4. Carreras I, Aytan N, Mellott T, Choi JK, Lehar M, Crabtree L, Leite-Morris K, Jenkins BG, Blusztajn JK, Dedeoglu A. Corrigendum to "Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease" [Brain Res. 1681 (2018) 34-43]. Brain Res. 2018 06 01; 1688:113-115.View Related Profiles. PMID: 29526415
     
  5. Aytan N, Choi JK, Carreras I, Crabtree L, Nguyen B, Lehar M, Blusztajn JK, Jenkins BG, Dedeoglu A. Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease. Eur J Pharmacol. 2018 Jun 05; 828:9-17.View Related Profiles. PMID: 29510124
     
  6. Carreras I, Aytan N, Mellott T, Choi JK, Lehar M, Crabtree L, Leite-Morris K, Jenkins BG, Blusztajn JK, Dedeoglu A. Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease. Brain Res. 2018 02 15; 1681:34-43.View Related Profiles. PMID: 29277710
     
  7. Kantarci A, Aytan N, Palaska I, Stephens D, Crabtree L, Benincasa C, Jenkins BG, Carreras I, Dedeoglu A. Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease. Exp Neurol. 2018 02; 300:111-120.View Related Profiles. PMID: 29126887
     
  8. Aytan N, Choi JK, Carreras I, Brinkmann V, Kowall NW, Jenkins BG, Dedeoglu A. Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease. Sci Rep. 2016 04 27; 6:24939.View Related Profiles. PMID: 27117087; PMCID: PMC4847010; DOI: 10.1038/srep24939;
     
  9. Jenkins BG, Zhu A, Poutiainen P, Choi JK, Kil KE, Zhang Z, Kuruppu D, Aytan N, Dedeoglu A, Brownell AL. Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration. Neuropharmacology. 2016 Sep; 108:462-73.View Related Profiles. PMID: 26581500; PMCID: PMC4896842; DOI: 10.1016/j.neuropharm.2015.11.010;
     
  10. Choi JK, Carreras I, Aytan N, Jenkins-Sahlin E, Dedeoglu A, Jenkins BG. The effects of aging, housing and ibuprofen treatment on brain neurochemistry in a triple transgene Alzheimer's disease mouse model using magnetic resonance spectroscopy and imaging. Brain Res. 2014 Nov 24; 1590:85-96.View Related Profiles. PMID: 25301691; PMCID: PMC4274938; DOI: 10.1016/j.brainres.2014.09.067;
     
Showing 10 of 50 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 50 publications over 18 distinct years, with a maximum of 9 publications in 2001

YearPublications
20004
20019
20026
20033
20043
20051
20072
20081
20094
20102
20133
20143
20151
20161
20172
20183
20191
20201

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