Thomas Van Dyke, PhD
Adjunct Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology

PhD, State University of New York at Buffalo
DDS, Case Western Reserve University
MS, State University of New York at Buffalo
BA, Case Western Reserve University
CAGS, State University of New York at Buffalo

Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Chobanian and Avedisian School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

Neutrophils and Periodontitis in Diabetes
04/01/2005 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE15566 06

Specialized Center for Anti-Inflammation and Resolution in Periodontal Disease Project 3
09/17/2004 - 07/31/2009 (PI)
Brigham & Women's Hospital NIH NIDCR

Effects of Chewing Gum on Gingivitis and Inflammatory Markers
02/01/2008 - 12/31/2008 (PI)
Wrigley Jr. Company

A 9 Month Multicenter Clinical Trial of the Treatment with Periocline (Minocycline) Gel 2%
07/21/2005 - 10/31/2008 (PI)
Sunstar Butler

Clinical Research Study Evaluating Commercial Products to Calibrate a New Clinical Site for the Quigley Hein Plaque Index
10/01/2007 - 09/30/2008 (PI)

02/01/2007 - 09/30/2008 (PI)
Other Industry

Biological Bases of Refractory Periodontal Diseases
06/01/2002 - 04/30/2008 (PI)
Forsyth Institute NIH NIDCR

The Use of Hard Tissue Replacement and Polyanhydride Graft Material Formulations Around Implants Immediately Placed into Extraction Sockets: Immediate Stability and Function - A Proof of Concept Study in a Mini-Pig Model
07/01/2007 - 03/31/2008 (PI)
Bioplant R&D, L.L.C.

H2 Antagonist Technology for the Prevention and/or Treatment of Gingivitis and/or Periodontitis
10/01/2002 - 09/30/2007 (PI)
Procter & Gamble

Nitric Oxide Defense Against Porphyromonas Gingivalis
01/01/2003 - 12/31/2006 (Dept Sponsor)
NIH/National Institute of Dental & Craniofacial Research
1 K22 DE14568 01A1

Showing 10 of 35 results. Show All Results


Yr Title Project-Sub Proj Pubs
2023 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 3R01DE025020-09S1
2023 Forsyth Training in Oral Health Research 5R90DE027638-07
2023 Forsyth Training in Oral Health Research 5T90DE026110-07
2023 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-09
2022 Forsyth Training in Oral Health Research 2T90DE026110-06
2022 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-08
2021 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-05 2
2021 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-05
2021 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-07 21
2020 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-04
Showing 10 of 128 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Castro Dos Santos N, Westphal MR, Retamal-Valdes B, Duarte PM, Figueiredo LC, Faveri M, Shibli J, Soares G, Miranda T, Fermiano D, Borges I, Goncalves C, Tanaka CJ, Teles F, Goodson M, Hasturk H, Van Dyke T, Ehmke B, Eickholz P, Nickles K, Schlagenhauf U, Meyle J, Kocher T, Kim TS, Doyle H, Feres M. Influence of gender on periodontal outcomes: A retrospective analysis of eight randomized clinical trials. J Periodontal Res. 2024 May 06. PMID: 38708933
  2. Ma KS, Chan SY, Van Dyke TE, Wang SI, Wei JC, Ashina S. Tooth Loss and Chronic Pain: A Population-based Analysis of the National Health and Nutrition Examination Survey. J Pain. 2024 Apr 06; 104529. PMID: 38588761
  3. Abdalla HB, Puhl L, Rivas CA, Wu YC, Rojas P, Trindade-da-Silva CA, Hammock BD, Maddipati KR, Soares MQS, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE. Modulating the sEH/EETs Axis Restrains Specialized Proresolving Mediator Impairment and Regulates T Cell Imbalance in Experimental Periodontitis. J Immunol. 2024 Feb 01; 212(3):433-445. PMID: 38117781; PMCID: PMC10866374; DOI: 10.4049/jimmunol.2300650;
  4. Yang Y, Alves T, Miao MZ, Wu YC, Li G, Lou J, Hasturk H, Van Dyke TE, Kantarci A, Wu D. Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells. J Dent Res. 2024 Jan; 103(1):71-80. PMID: 37982164; PMCID: PMC10850875; DOI: 10.1177/00220345231205283;
  5. Liu Y, Zhu ZX, Zboinski EK, Qiu W, Lian J, Liu S, Van Dyke TE, Johansson HE, Tu Q, Luo E, Chen JJ. Long non-coding RNA APDC plays important regulatory roles in metabolism of bone and adipose tissues. RNA Biol. 2023 Jan; 20(1):836-846. PMID: 37953645; PMCID: PMC10653663; DOI: 10.1080/15476286.2023.2268489;
  6. Sahni V, Van Dyke TE. Immunomodulation of periodontitis with SPMs. Front Oral Health. 2023; 4:1288722. PMID: 37927821; PMCID: PMC10623003; DOI: 10.3389/froh.2023.1288722;
  7. Wu YC, Yu N, Rivas CA, Mehrnia N, Kantarci A, Van Dyke TE. RvE1 Promotes Axin2+ Cell Regeneration and Reduces Bacterial Invasion. J Dent Res. 2023 Dec; 102(13):1478-1487. PMID: 37837227; PMCID: PMC10767698; DOI: 10.1177/00220345231197156;
  8. Zhu ZX, Liu Y, Wang J, Xie Y, Li RY, Ma Q, Tu Q, Melhem NA, Couldwell S, El-Araby RE, Tai A, Van Dyke TE, Karimbux N, Jeong YN, Chen JJ. A novel lncRNA-mediated epigenetic regulatory mechanism in periodontitis. Int J Biol Sci. 2023; 19(16):5187-5203. PMID: 37928259; PMCID: PMC10620817; DOI: 10.7150/ijbs.87977;
  9. Lee CT, Abusleme L, Van Dyke TE. Editorial: The impact of inflammation on the oral microbiome. Front Oral Health. 2023; 4:1293228. PMID: 37808608; PMCID: PMC10557251; DOI: 10.3389/froh.2023.1293228;
  10. Huang RY, Tseng FY, Cheng CD, Van Dyke TE, Sung CE, You JJ, Weng PW, Shieh YS, Cheng WC. Complement components C3b and C4b as potential reliable site-specific diagnostic biomarkers for periodontitis. J Periodontal Res. 2023 Oct; 58(5):1020-1030. PMID: 37462259
Showing 10 of 426 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 424 publications over 45 distinct years, with a maximum of 21 publications in 2013


Contact for Mentoring:

100 E. Newton St Goldman SDM
Boston MA 02118
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