Thomas Van Dyke, PhD
Adjunct Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Molecular & Cell Biology

PhD, State University of New York at Buffalo
MS, State University of New York at Buffalo
CAGS-Certificate of Advanced Graduate St, State University of New York at Buffalo
DDS, Case Western Reserve University



Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Chobanian and Avedisian School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Boston Medical Center




Neutrophils and Periodontitis in Diabetes
04/01/2005 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE15566 06

Specialized Center for Anti-Inflammation and Resolution in Periodontal Disease Project 3
09/17/2004 - 07/31/2009 (PI)
Brigham & Women's Hospital NIH NIDCR

Effects of Chewing Gum on Gingivitis and Inflammatory Markers
02/01/2008 - 12/31/2008 (PI)
Wrigley Jr. Company

A 9 Month Multicenter Clinical Trial of the Treatment with Periocline (Minocycline) Gel 2%
07/21/2005 - 10/31/2008 (PI)
Sunstar Butler

Clinical Research Study Evaluating Commercial Products to Calibrate a New Clinical Site for the Quigley Hein Plaque Index
10/01/2007 - 09/30/2008 (PI)
Colgate-Palmolive

CLINICAL RESEARCH STUDY EVALUATING COMMERCIAL PRODUCTS TO CALIBRATE A NEW CLINICAL SITE FOR TEH QUICGLEY HEIN PLAQUE INDEX
02/01/2007 - 09/30/2008 (PI)
Other Industry


Biological Bases of Refractory Periodontal Diseases
06/01/2002 - 04/30/2008 (PI)
Forsyth Institute NIH NIDCR

The Use of Hard Tissue Replacement and Polyanhydride Graft Material Formulations Around Implants Immediately Placed into Extraction Sockets: Immediate Stability and Function - A Proof of Concept Study in a Mini-Pig Model
07/01/2007 - 03/31/2008 (PI)
Bioplant R&D, L.L.C.

H2 Antagonist Technology for the Prevention and/or Treatment of Gingivitis and/or Periodontitis
10/01/2002 - 09/30/2007 (PI)
Procter & Gamble

Nitric Oxide Defense Against Porphyromonas Gingivalis
01/01/2003 - 12/31/2006 (Dept Sponsor)
NIH/National Institute of Dental & Craniofacial Research
1 K22 DE14568 01A1

Showing 10 of 35 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Forsyth Training in Oral Health Research 2T90DE026110-06
2022 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-08
2021 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-05
2021 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-05 2
2021 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-07 21
2020 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-04
2020 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-04 2
2020 Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes 5U01DE025383-06 1
2020 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-06 21
2019 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-03
Showing 10 of 124 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Wu H, Qiu W, Zhu X, Li X, Xie Z, Carreras I, Dedeoglu A, Van Dyke T, Han YW, Karimbux N, Tu Q, Cheng L, Chen J. The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways. Front Aging Neurosci. 2022; 14:912709.View Related Profiles. PMID: 35813949; PMCID: PMC9260256; DOI: 10.3389/fnagi.2022.912709;
     
  2. Shaikh SR, Virk R, Van Dyke TE. Potential Mechanisms by Which Hydroxyeicosapentaenoic Acids Regulate Glucose Homeostasis In Obesity. Adv Nutr. 2022 Jun 16. PMID: 35709423
     
  3. Panezai J, Van Dyke TE. Resolution of inflammation: Intervention strategies and future applications. Toxicol Appl Pharmacol. 2022 Aug 15; 449:116089. PMID: 35644268
     
  4. Gellibolian R, Miller CS, Markaryan AN, Weltman RL, Van Dyke TE, Ebersole JL. Precision periodontics: Quantitative measures of disease progression. J Am Dent Assoc. 2022 Sep; 153(9):826-828. PMID: 35525683
     
  5. Papathanasiou E, Scott AR, Trotman CA, Beale C, Price LL, Huggins GS, Zhang Y, Georgakoudi I, Van Dyke TE. Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair. Front Immunol. 2022; 13:871200. PMID: 35572588; PMCID: PMC9094441; DOI: 10.3389/fimmu.2022.871200;
     
  6. Hu Z, Qiu W, Yu Y, Wu X, Fang F, Zhu X, Xu X, Tu Q, Van Dyke TE, Morgan EF, Chen J. Identification and Characterization of a Novel Long Noncoding RNA that Regulates Osteogenesis in Diet-Induced Obesity Mice. Front Cell Dev Biol. 2022; 10:832460.View Related Profiles. PMID: 35531098; PMCID: PMC9068931; DOI: 10.3389/fcell.2022.832460;
     
  7. Rakian A, Rakian R, Shay AE, Serhan CN, Van Dyke TE. Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3. J Dent Res. 2022 Sep; 101(10):1205-1213. PMID: 35428422; PMCID: PMC9403725; DOI: 10.1177/00220345221090879;
     
  8. Panezai J, Ghaffar A, Altamash M, Åberg M, Van Dyke TE, Larsson A, Engström PE. Periodontal Disease Augments Cardiovascular Disease Risk Biomarkers in Rheumatoid Arthritis. Biomedicines. 2022 Mar 19; 10(3). PMID: 35327515; PMCID: PMC8945365; DOI: 10.3390/biomedicines10030714;
     
  9. Castro Dos Santos NC, Furukawa MV, Oliveira-Cardoso I, Cortelli JR, Feres M, Van Dyke T, Rovai ES. Does the use of omega-3 fatty acids as an adjunct to non-surgical periodontal therapy provide additional benefits in the treatment of periodontitis? A systematic review and meta-analysis. J Periodontal Res. 2022 Jun; 57(3):435-447. PMID: 35243637
     
  10. Wu X, Sun Y, Cui R, Qiu W, Zhang J, Hu Z, Bi W, Yang F, Ma D, Van Dyke T, Tu Q, Yu Y, Chen J. A novel adiponectin receptor agonist (AdipoAI) ameliorates type 2 diabetes-associated periodontitis by enhancing autophagy in osteoclasts. J Periodontal Res. 2022 Apr; 57(2):381-391. PMID: 34984683; PMCID: PMC9380722; DOI: 10.1111/jre.12969;
     
Showing 10 of 403 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 401 publications over 43 distinct years, with a maximum of 21 publications in 2013

YearPublications
19802
19812
19825
19831
19843
19854
19865
19874
19883
19894
19905
199112
19927
199312
199414
19955
199611
19978
19986
19997
20007
20015
200212
200313
200412
200518
200611
200713
200816
200914
201013
20118
20128
201321
201418
201513
201611
201711
20189
20197
202015
202116
202210

Contact for Mentoring:

100 E. Newton St Goldman SDM
Boston MA 02118
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