Thomas Van Dyke, PhD
Adjunct Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology

PhD, State University of New York at Buffalo
DDS, Case Western Reserve University
MS, State University of New York at Buffalo
BA, Case Western Reserve University
CAGS, State University of New York at Buffalo



Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Chobanian and Avedisian School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Boston Medical Center




Neutrophils and Periodontitis in Diabetes
04/01/2005 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE15566 06

Specialized Center for Anti-Inflammation and Resolution in Periodontal Disease Project 3
09/17/2004 - 07/31/2009 (PI)
Brigham & Women's Hospital NIH NIDCR

Effects of Chewing Gum on Gingivitis and Inflammatory Markers
02/01/2008 - 12/31/2008 (PI)
Wrigley Jr. Company

A 9 Month Multicenter Clinical Trial of the Treatment with Periocline (Minocycline) Gel 2%
07/21/2005 - 10/31/2008 (PI)
Sunstar Butler

Clinical Research Study Evaluating Commercial Products to Calibrate a New Clinical Site for the Quigley Hein Plaque Index
10/01/2007 - 09/30/2008 (PI)
Colgate-Palmolive

CLINICAL RESEARCH STUDY EVALUATING COMMERCIAL PRODUCTS TO CALIBRATE A NEW CLINICAL SITE FOR TEH QUICGLEY HEIN PLAQUE INDEX
02/01/2007 - 09/30/2008 (PI)
Other Industry


Biological Bases of Refractory Periodontal Diseases
06/01/2002 - 04/30/2008 (PI)
Forsyth Institute NIH NIDCR

The Use of Hard Tissue Replacement and Polyanhydride Graft Material Formulations Around Implants Immediately Placed into Extraction Sockets: Immediate Stability and Function - A Proof of Concept Study in a Mini-Pig Model
07/01/2007 - 03/31/2008 (PI)
Bioplant R&D, L.L.C.

H2 Antagonist Technology for the Prevention and/or Treatment of Gingivitis and/or Periodontitis
10/01/2002 - 09/30/2007 (PI)
Procter & Gamble

Nitric Oxide Defense Against Porphyromonas Gingivalis
01/01/2003 - 12/31/2006 (Dept Sponsor)
NIH/National Institute of Dental & Craniofacial Research
1 K22 DE14568 01A1

Showing 10 of 35 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Forsyth Training in Oral Health Research 5T90DE026110-08
2024 Forsyth Training in Oral Health Research 5R90DE027638-08
2023 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 3R01DE025020-09S1
2023 Forsyth Training in Oral Health Research 5T90DE026110-07
2023 Forsyth Training in Oral Health Research 5R90DE027638-07
2023 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-09
2022 Forsyth Training in Oral Health Research 2T90DE026110-06
2022 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-08
2021 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-05
2021 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-05 2
Showing 10 of 130 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Uttamani JR, Kulkarni V, Valverde A, Naqvi RA, Van Dyke T, Nares S, Naqvi AR. Dynamic changes in macrophage polarization during the resolution phase of periodontal disease. Immun Inflamm Dis. 2024 Oct; 12(10):e70044. PMID: 39436204; PMCID: PMC11494820; DOI: 10.1002/iid3.70044;
     
  2. Wang LT, Juang SE, Chang HH, He AC, Chen WA, Huang YW, Van Dyke TE, Ma KS, Chen YW. Single-cell analysis of peri-implant gingival tissue to assess implant biocompatibility and immune response. J Prosthodont Res. 2024 Sep 03. PMID: 39231696
     
  3. Tezcan G, Yakar N, Hasturk H, Van Dyke TE, Kantarci A. Resolution of chronic inflammation and cancer. Periodontol 2000. 2024 Aug 23. PMID: 39177291
     
  4. Elebyary O, Sun C, Batistella EA, Van Dyke TE, Low SB, Singhal S, Tenenbaum H, Glogauer M. Utilizing Oral Neutrophil Counts as an Indicator of Oral Inflammation Associated With Periodontal Disease: A Blinded Multicentre Study. J Clin Periodontol. 2024 Nov; 51(11):1410-1420. PMID: 39161194
     
  5. Kirkwood KL, Van Dyke TE, Kirkwood CL, Zhang L, Panezai J, Duran-Pinedo AE, Figgins EL, Ryan LK, Frias-Lopez JJ, Diamond G. Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model. J Dent Res. 2024 Aug; 103(9):908-915. PMID: 39104028; PMCID: PMC11465324; DOI: 10.1177/00220345241259417;
     
  6. Tubero Euzebio Alves V, Alves T, Silva Rovai E, Hasturk H, Van Dyke T, Holzhausen M, Kantarci A. Arginine-specific gingipains (RgpA/RgpB) knockdown modulates neutrophil machinery. J Oral Microbiol. 2024; 16(1):2376462. PMID: 38988325; PMCID: PMC11234918; DOI: 10.1080/20002297.2024.2376462;
     
  7. Ma KS, Chiang CH, Chen ST, Dinh Y, Chiang CH, Van Dyke TE, Sullivan R, Ananthakrishnan AN, Hsia YP, Peng CM, Chiang CH. Periodontitis is an immune-related adverse event associated with immune checkpoint inhibitors: A multi-center cohort study. Cancer Lett. 2024 Aug 28; 598:217100. PMID: 38969158
     
  8. Suárez LJ, Hasturk H, Tubero Euzebio Alves V, Díaz-Baez D, Van Dyke T, Kantarci A. Overexpression of the receptor for resolvin E1 (ERV1) prevents early alveolar bone loss in leptin receptor deficiency-induced diabetes. J Periodontol. 2024 Jun 21. PMID: 39031577
     
  9. Castro Dos Santos N, Westphal MR, Retamal-Valdes B, Duarte PM, Figueiredo LC, Faveri M, Shibli J, Soares G, Miranda T, Fermiano D, Borges I, Goncalves C, Tanaka CJ, Teles F, Goodson M, Hasturk H, Van Dyke T, Ehmke B, Eickholz P, Nickles K, Schlagenhauf U, Meyle J, Kocher T, Kim TS, Doyle H, Feres M. Influence of gender on periodontal outcomes: A retrospective analysis of eight randomized clinical trials. J Periodontal Res. 2024 May 06. PMID: 38708933
     
  10. Ma KS, Chan SY, Van Dyke TE, Wang SI, Wei JC, Ashina S. Tooth Loss and Chronic Pain: A Population-based Analysis of the National Health and Nutrition Examination Survey. J Pain. 2024 Sep; 25(9):104529. PMID: 38588761
     
Showing 10 of 434 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 432 publications over 45 distinct years, with a maximum of 21 publications in 2013

YearPublications
19802
19812
19825
19831
19843
19854
19865
19874
19883
19894
19905
199112
19927
199312
199414
19955
199611
19978
19986
19997
20007
20015
200212
200313
200412
200518
200611
200713
200816
200914
201013
20118
20128
201321
201418
201513
201611
201711
20189
20197
202015
202116
202215
202315
202411

Contact for Mentoring:

100 E. Newton St Goldman SDM
Boston MA 02118
Google Map


Van Dyke's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department