Thomas Van Dyke, PhD
Adjunct Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology

PhD, State University of New York at Buffalo
MS, State University of New York at Buffalo
BA, Case Western Reserve University
CAGS, State University of New York at Buffalo
DDS, Case Western Reserve University

Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Chobanian and Avedisian School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

Neutrophils and Periodontitis in Diabetes
04/01/2005 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE15566 06

Specialized Center for Anti-Inflammation and Resolution in Periodontal Disease Project 3
09/17/2004 - 07/31/2009 (PI)
Brigham & Women's Hospital NIH NIDCR

Effects of Chewing Gum on Gingivitis and Inflammatory Markers
02/01/2008 - 12/31/2008 (PI)
Wrigley Jr. Company

A 9 Month Multicenter Clinical Trial of the Treatment with Periocline (Minocycline) Gel 2%
07/21/2005 - 10/31/2008 (PI)
Sunstar Butler

Clinical Research Study Evaluating Commercial Products to Calibrate a New Clinical Site for the Quigley Hein Plaque Index
10/01/2007 - 09/30/2008 (PI)

02/01/2007 - 09/30/2008 (PI)
Other Industry

Biological Bases of Refractory Periodontal Diseases
06/01/2002 - 04/30/2008 (PI)
Forsyth Institute NIH NIDCR

The Use of Hard Tissue Replacement and Polyanhydride Graft Material Formulations Around Implants Immediately Placed into Extraction Sockets: Immediate Stability and Function - A Proof of Concept Study in a Mini-Pig Model
07/01/2007 - 03/31/2008 (PI)
Bioplant R&D, L.L.C.

H2 Antagonist Technology for the Prevention and/or Treatment of Gingivitis and/or Periodontitis
10/01/2002 - 09/30/2007 (PI)
Procter & Gamble

Nitric Oxide Defense Against Porphyromonas Gingivalis
01/01/2003 - 12/31/2006 (Dept Sponsor)
NIH/National Institute of Dental & Craniofacial Research
1 K22 DE14568 01A1

Showing 10 of 35 results. Show All Results


Yr Title Project-Sub Proj Pubs
2023 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 3R01DE025020-09S1
2023 Forsyth Training in Oral Health Research 5R90DE027638-07
2023 Forsyth Training in Oral Health Research 5T90DE026110-07
2023 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-09
2022 Forsyth Training in Oral Health Research 2T90DE026110-06
2022 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-08
2021 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-05 2
2021 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-05
2021 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 5R01DE025020-07 21
2020 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-04
Showing 10 of 128 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Huang RY, Tseng FY, Cheng CD, Van Dyke TE, Sung CE, You JJ, Weng PW, Shieh YS, Cheng WC. Complement components C3b and C4b as potential reliable site-specific diagnostic biomarkers for periodontitis. J Periodontal Res. 2023 Oct; 58(5):1020-1030. PMID: 37462259
  2. Shinjo T, Onizuka S, Zaitsu Y, Ishikado A, Park K, Li Q, Yokomizo H, Zeze T, Sato K, St-Louis R, Fu J, I-Hsien W, Mizutani K, Hasturk H, Van Dyke TE, Nishimura F, King GL. Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice. Diabetes. 2023 Jul 01; 72(7):986-998. PMID: 37058471; PMCID: PMC10281234; DOI: 10.2337/db22-1014;
  3. Janket SJ, Van Dyke TE, Meurman JH. The authors respond. Br Dent J. 2023 Jun; 234(11):783-784. PMID: 37291287
  4. Eltay EG, Van Dyke T. Resolution of inflammation in oral diseases. Pharmacol Ther. 2023 Jul; 247:108453. PMID: 37244405
  5. Kuo TY, Hsieh MC, Cheng CD, Huang RY, Van Dyke TE, Sung CE, Wang CY, Hsieh YS, Cheng WC. Chlorhexidine gel topical application ameliorates inflammatory bone loss in experimental periodontitis. J Formos Med Assoc. 2023 Sep; 122(9):899-910. PMID: 36801153
  6. Panezai J, van Dyke T. Polyunsaturated Fatty Acids and Their Immunomodulatory Actions in Periodontal Disease. Nutrients. 2023 Feb 05; 15(4). PMID: 36839179; PMCID: PMC9965392; DOI: 10.3390/nu15040821;
  7. Janket SJ, Lee C, Surakka M, Jangam TG, Van Dyke TE, Baird AE, Meurman JH. Oral hygiene, mouthwash usage and cardiovascular mortality during 18.8 years of follow-up. Br Dent J. 2023 Feb 03; 1-6. PMID: 36737459; PMCID: PMC9897600; DOI: 10.1038/s41415-023-5507-4;
  8. Abdalla HB, Alvarez C, Wu YC, Rojas P, Hammock BD, Maddipati KR, Trindade-da-Silva CA, Soares MQS, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE. Soluble epoxide hydrolase inhibition enhances production of specialized pro-resolving lipid mediator and promotes macrophage plasticity. Br J Pharmacol. 2023 Jun; 180(12):1597-1615. PMID: 36508312; PMCID: PMC10175184; DOI: 10.1111/bph.16009;
  9. Huang RY, Tseng FY, You JJ, Van Dyke TE, Cheng CD, Sung CE, Weng PW, Shieh YS, Cheng WC. Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis. J Clin Periodontol. 2023 May; 50(5):657-670. PMID: 36632003
  10. Shaikh SR, Virk R, Van Dyke TE. Potential Mechanisms by Which Hydroxyeicosapentaenoic Acids Regulate Glucose Homeostasis in Obesity. Adv Nutr. 2022 Dec 22; 13(6):2316-2328. PMID: 35709423; PMCID: PMC9776734; DOI: 10.1093/advances/nmac073;
Showing 10 of 417 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 415 publications over 44 distinct years, with a maximum of 21 publications in 2013


Contact for Mentoring:

100 E. Newton St Goldman SDM
Boston MA 02118
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