Thomas Van Dyke, PhD
Boston University
Evans Center for Interdisciplinary Biomedical Research

PhD, State University of New York at Buffalo
MS, State University of New York at Buffalo
CAGS-Certificate of Advanced Graduate St, State University of New York at Buffalo
DDS, Case Western Reserve University

Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Boston University School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Adjunct Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology

Boston Medical Center

Neutrophils and Periodontitis in Diabetes
04/01/2005 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE15566 06

Specialized Center for Anti-Inflammation and Resolution in Periodontal Disease Project 3
09/17/2004 - 07/31/2009 (PI)
Brigham & Women's Hospital NIH NIDCR

Effects of Chewing Gum on Gingivitis and Inflammatory Markers
02/01/2008 - 12/31/2008 (PI)
Wrigley Jr. Company

A 9 Month Multicenter Clinical Trial of the Treatment with Periocline (Minocycline) Gel 2%
07/21/2005 - 10/31/2008 (PI)
Sunstar Butler

10/01/2007 - 09/30/2008 (PI)
Other Industry

Clinical Research Study Evaluating Commercial Products to Calibrate a New Clinical Site for the Quigley Hein Plaque Index
10/01/2007 - 09/30/2008 (PI)

Biological Bases of Refractory Periodontal Diseases
06/01/2002 - 04/30/2008 (PI)
Forsyth Institute NIH NIDCR

The Use of Hard Tissue Replacement and Polyanhydride Graft Material Formulations Around Implants Immediately Placed into Extraction Sockets: Immediate Stability and Function - A Proof of Concept Study in a Mini-Pig Model
07/01/2007 - 03/31/2008 (PI)
Bioplant R&D, L.L.C.

H2 Antagonist Technology for the Prevention and/or Treatment of Gingivitis and/or Periodontitis
10/01/2002 - 09/30/2007 (PI)
Procter & Gamble

Nitric Oxide Defense Against Porphyromonas Gingivalis
01/01/2003 - 12/31/2006 (Dept Sponsor)
NIH/National Institute of Dental & Craniofacial Research
1 K22 DE14568 01A1

Showing 10 of 35 results. Show All Results


Yr Title Project-Sub Proj Pubs
2019 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-03 2
2019 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-03
2019 Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes 5U01DE025383-05 1
2019 Mechanisms of Pro-Resolving Mediators in Periodontal Regeneration 2R01DE025020-05 21
2018 Forsyth Postdoctoral Training in Oral Health Research 5R90DE027638-02
2018 Forsyth Postdoctoral Training in Oral Health Research 5T90DE026110-02 2
2018 Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes 5U01DE025383-04 1
2018 Mechanisms of Resolvin E1 in Periodontal Regeneration 5R01DE025020-04 21
2018 Mechanisms of Resolvin E1 in Periodontal Regeneration 3R01DE025020-04S1 21
2018 Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral Microbiom 5R01DE024468-05 19
Showing 10 of 115 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. El Kholy K, Buser D, Wittneben JG, Bosshardt DD, Van Dyke TE, Kowolik MJ. Investigating the Response of Human Neutrophils to Hydrophilic and Hydrophobic Micro-Rough Titanium Surfaces. Materials (Basel). 2020 Aug 03; 13(15). PMID: 32756413
  2. Ferguson B, Bokka NR, Maddipati KR, Ayilavarapu S, Weltman R, Zhu L, Chen W, Zheng WJ, Angelov N, Van Dyke TE, Lee CT. Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation. Front Immunol. 2020; 11:1307. PMID: 32670289
  3. Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000. 2020 06; 83(1):26-39. PMID: 32385877
  4. Curtis MA, Diaz PI, Van Dyke TE. The role of the microbiota in periodontal disease. Periodontol 2000. 2020 06; 83(1):14-25. PMID: 32385883
  5. Van Dyke TE. Shifting the paradigm from inhibitors of inflammation to resolvers of inflammation in periodontitis. J Periodontol. 2020 May 22. PMID: 32441774
  6. Abdalla HB, Napimoga MH, Lopes AH, de Macedo Maganin AG, Cunha TM, Van Dyke TE, Clemente Napimoga JT. Activation of PPAR-? induces macrophage polarization and reduces neutrophil migration mediated by heme oxygenase 1. Int Immunopharmacol. 2020 Jul; 84:106565. PMID: 32388213
  7. Feres M, Retamal-Valdes B, Faveri M, Duarte P, Shibli J, Soares GMS, Miranda T, Teles F, Goodson M, Hasturk H, Van Dyke T, Ehmke B, Eickholz P, Schlagenhauf U, Meyle J, Koch R, Kocher T, Hoffmann T, Kim TS, Kaner D, Figueiredo LC, Doyle H. Proposal of a Clinical Endpoint for Periodontal Trials: The Treat-to-Target Approach. J Int Acad Periodontol. 2020 04 01; 22(2):41-53. PMID: 32224549
  8. Van Dyke TE, Bartold PM, Reynolds EC. The Nexus Between Periodontal Inflammation and Dysbiosis. Front Immunol. 2020; 11:511. PMID: 32296429
  9. Castro Dos Santos NC, Andere NMRB, Araujo CF, de Marco AC, Kantarci A, Van Dyke TE, Santamaria MP. Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial. J Periodontol. 2020 Feb 26. PMID: 32103495
  10. Van Dyke TE, Sima C. Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve? Periodontol 2000. 2020 02; 82(1):205-213. PMID: 31850636
Showing 10 of 370 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 368 publications over 41 distinct years, with a maximum of 21 publications in 2013


Contact for Mentoring:

100 E. Newton St Goldman SDM
Boston MA 02118
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