Paul A. Monach, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology (Arthritis)

MD, University of Chicago
PhD, University of Chicago




My research is focused on clinical and translational research in vasculitis: biomarkers, genetics, and clinical trials.

I have led studies aimed at identifying new markers that could improve diagnosis, staging, assessment of current disease activity, and predicting the future course of disease, using proteins detectable in the blood or urine and gene expression profiles in blood cells.

I have also led candidate genes studies in vasculitis and has been involved in the planning and recruitment for genome-wide association studies in multiple forms of vasculitis.

I have participated in most multi-center clinical trials conducted over the past 10 years in the US, in various vasculitides.

This work has been conducted through NIH-funded consortia: the Vasculitis Clinical Research Consortium and the RAVE/ITN Study Group. In addition, I have been a member of the Immunological Genome Project Consortium and contributed data on gene expression in mouse neutrophils to that effort.

2016-2018 Boston Magazine: Boston’s Top Doctors
2015-2018 America’s Top Doctors
2006 Arthritis Foundation: J.V. Satterfield Arthritis Investigator Award
1999 Leon O. Jacobson Basic Science Prize
1999 John Van Prohaska Award
1999 Gate Pharmaceuticals Award
1995 Dr. Harold Lamport Award
1995 Committee on Immunology Award
1989 Henderson Prize
1989 Hoopes Prize


Mepolizumab Long-term Access Programme for Subjects who Participated in Study MEA115921
12/24/2015 - 06/30/2020 (PI)
GlaxoSmithKline, Inc.


Abatacept (CTLA4_Ig) For the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyaugiitis (Wegener's) (ABROGATE)
03/10/2015 - 03/09/2020 (PI)
Cleveland Clinic Foundation Bristol-Myers Squibb


A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculiti
02/28/2017 - 02/27/2020 (PI)
ChemoCentryx, Inc.


Vasculitis Clinical Research Consortium-ARAMIS Pilot
01/01/2017 - 08/31/2019 (Co-PI)
PI: Christina Lam, MD
Trustees of the University of Pennsylvania NIH NIAMS
5U54AR057319-16

Prospective, Observational Safety Study of Patients with Wegener's Granulomatosis (Granulomatosis with Polyangitis) or Microscopic Polyangitis Treated with Rituximab
03/01/2012 - 02/28/2019 (PI)
Hoffmann-La Roche Inc (Foreign)


A Double-blind, Randomised, Placebo-controlled Study to Investigate the Efficacy and Safety of Mepolizumab in the Treatment of Eosinophilic Granulomatosis with Polyangiitis in Subjects Receiving Stand
09/24/2014 - 12/31/2018 (PI)
GlaxoSmithKline, Inc.


Vasculitis Clinical Research Foundation
09/01/2017 - 08/31/2018 (PI)
Trustees of the University of Pennsylvania NIH NIAMS
5U54AR057319-15

Adaptation and Validation of PROMIS for use in Vasculitis
09/15/2012 - 08/31/2018 (PI)
Trustees of the University of Pennsylvania NIH NIAMS
5R01AR064153-04

Identification of Shared Molecular Targets
07/01/2017 - 06/30/2018 (PI)
Trustees of the University of Pennsylvania NIH NCATS
9U01TR001263-11

Novel Methods for the Conduct of Clinical Trials
06/01/2016 - 05/31/2018 (PI)
Trustees of the University of Pennsylvania NIH NHLBI
4R01HL115041-04

Showing 10 of 24 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kronbichler A, Leierer J, Shin JI, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CGM, St Clair EW, Brunetta P, Fervenza FC, Geetha D, Keogh KA, Monach PA, Ytterberg SR, Mayer G, Specks U, Stone JH. The Association of Pulmonary Haemorrhage, Positive PR3-ANCA and Urinary Red Blood Cell Casts with Venous Thromboembolism in ANCA-Associated Vasculitis. Arthritis Rheumatol. 2019 Jun 19. PMID: 31216123.
     
  2. Quinn KA, Gelbard A, Sibley C, Sirajuddin A, Ferrada MA, Chen M, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Pagnoux C, Seo P, Specks U, Sreih AG, Ytterberg SR, Merkel PA, Grayson PC. Subglottic stenosis and endobronchial disease in granulomatosis with polyangiitis. Rheumatology (Oxford). 2019 Jun 14. PMID: 31199488.
     
  3. Wallace ZS, Fu X, Liao K, Kallenberg CGM, Langford CA, Merkel PA, Monach P, Seo P, Specks U, Spiera R, St Clair EW, Zhang Y, Choi H, Stone JH. Disease Activity, ANCA-Type, and Lipid Levels in ANCA-Associated Vasculitis. Arthritis Rheumatol. 2019 Jun 04. PMID: 31162829.
     
  4. Tomasson G, Farrar JT, Cuthbertson D, McAlear CA, Ashdown S, Cronholm PF, Dawson J, Gebhart D, Lanier G, Luqmani RA, Milman N, Peck J, Robson JC, Shea JA, Carette S, Khalidi N, Koening CL, Langford CA, Monach PA, Moreland L, Pagnoux C, Specks U, Sreih AG, Ytterberg SR, Merkel PA. Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis. J Rheumatol. 2019 Mar 01. PMID: 30824648.
     
  5. Pagnoux C, Nair P, Xi Y, Khalidi NA, Carette S, Cuthbertson D, Grayson PC, Koening CL, Langford CA, McAlear CA, Moreland LW, Monach PA, Seo P, Specks U, Sreih AG, Ytterberg SR, Tyrrell PN, Merkel PA. Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma. Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):40-44. PMID: 30652675.
     
  6. Moran SM, Monach PA, Zgaga L, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Pagnoux C, Seo P, Specks U, Sreih A, Wyse J, Ytterberg SR, Merkel PA, Little MA. Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrol Dial Transplant. 2018 Oct 31. PMID: 30380100.
     
  7. Sreih AG, Ezzedine R, Leng L, Fan J, Yao J, Reid D, Piecychna M, Carette S, Cuthbertson D, Dellaripa P, Hoffman GS, Khalidi NA, Koening CL, Langford CA, Mahr A, McAlear CA, Maksimowicz-Mckinnon K, Monach PA, Seo P, Specks U, St Clair EW, Stone JH, Ytterberg SR, Edberg J, Merkel PA, Bucala R. Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis. Arthritis Rheumatol. 2018 Dec; 70(12):2077-2086. PMID: 29953750.
     
  8. Conklin LS, Merkel PA, Pachman LM, Parikh H, Tawalbeh S, Damsker JM, Cuthbertson DD, Morgan GA, Monach PA, Hathout Y, Nagaraju K, van den Anker J, McAlear CA, Hoffman EP. Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis. Steroids. 2018 12; 140:159-166. PMID: 30352204.
     
  9. Rhee RL, Holweg CTJ, Wong K, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Pagnoux C, Seo P, Specks U, Sreih AG, Ytterberg SR, Merkel PA. Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis. PLoS One. 2018; 13(10):e0205768. PMID: 30308057.
     
  10. Springer JM, Monach P, Cuthbertson D, Carette S, Khalidi NA, McAlear CA, Pagnoux C, Seo P, Warrington KJ, Ytterberg SR, Hoffman G, Langford C, Hamilton T, Foell D, Vogl T, Holzinger D, Merkel PA, Roth J, Hajj-Ali RA. Serum S100 Proteins as a Marker of Disease Activity in Large Vessel Vasculitis. J Clin Rheumatol. 2018 Oct; 24(7):393-395. PMID: 29470262.
     
Showing 10 of 103 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 103 publications over 23 distinct years, with a maximum of 14 publications in 2015 and 2017

YearPublications
19901
19911
19931
19951
19961
19991
20011
20031
20041
20052
20074
20081
20093
20105
20114
20127
201313
20146
201514
20165
201714
201811
20195
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomarkers
Vasculitis

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75 E. Newton St Evans Building
Boston MA 02118
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