Paul A. Monach, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology

MD, University of Chicago
PhD, University of Chicago




My research is focused on clinical and translational research in vasculitis: biomarkers, genetics, and clinical trials.

I have led studies aimed at identifying new markers that could improve diagnosis, staging, assessment of current disease activity, and predicting the future course of disease, using proteins detectable in the blood or urine and gene expression profiles in blood cells.

I have also led candidate genes studies in vasculitis and has been involved in the planning and recruitment for genome-wide association studies in multiple forms of vasculitis.

I have participated in most multi-center clinical trials conducted over the past 10 years in the US, in various vasculitides.

This work has been conducted through NIH-funded consortia: the Vasculitis Clinical Research Consortium and the RAVE/ITN Study Group. In addition, I have been a member of the Immunological Genome Project Consortium and contributed data on gene expression in mouse neutrophils to that effort.

VA Boston Healthcare System



2016-2018 Boston Magazine: Boston’s Top Doctors
2015-2018 America’s Top Doctors
2006 Arthritis Foundation: J.V. Satterfield Arthritis Investigator Award
1999 Leon O. Jacobson Basic Science Prize
1999 John Van Prohaska Award
1999 Gate Pharmaceuticals Award
1995 Dr. Harold Lamport Award
1995 Committee on Immunology Award
1989 Henderson Prize
1989 Hoopes Prize


Mepolizumab Long-term Access Programme for Subjects who Participated in Study MEA115921
12/24/2015 - 06/30/2020 (PI)
GlaxoSmithKline, Inc.


Abatacept (CTLA4_Ig) For the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyaugiitis (Wegener's) (ABROGATE)
03/10/2015 - 03/09/2020 (Subcontract PI)
Cleveland Clinic Foundation Bristol-Myers Squibb


A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculiti
02/28/2017 - 02/27/2020 (PI)
ChemoCentryx, Inc.


Vasculitis Clinical Research Consortium-ARAMIS Pilot
01/01/2017 - 08/31/2019 (Subcontract Co-PI)
Trustees of the University of Pennsylvania NIH NIAMS
5U54AR057319-16

Prospective, Observational Safety Study of Patients with Wegener's Granulomatosis (Granulomatosis with Polyangitis) or Microscopic Polyangitis Treated with Rituximab
03/01/2012 - 02/28/2019 (PI)
Hoffmann-La Roche Inc (Foreign)


A Double-blind, Randomised, Placebo-controlled Study to Investigate the Efficacy and Safety of Mepolizumab in the Treatment of Eosinophilic Granulomatosis with Polyangiitis in Subjects Receiving Stand
09/24/2014 - 12/31/2018 (PI)
GlaxoSmithKline, Inc.


Vasculitis Clinical Research Foundation
09/01/2017 - 08/31/2018 (Subcontract PI)
Trustees of the University of Pennsylvania NIH NIAMS
5U54AR057319-15

Adaptation and Validation of PROMIS for use in Vasculitis
09/15/2012 - 08/31/2018 (Subcontract PI)
Trustees of the University of Pennsylvania NIH NIAMS
5R01AR064153-04

Identification of Shared Molecular Targets
07/01/2017 - 06/30/2018 (Subcontract PI)
Trustees of the University of Pennsylvania NIH NCATS
9U01TR001263-11

Novel Methods for the Conduct of Clinical Trials
06/01/2016 - 05/31/2018 (Subcontract PI)
Trustees of the University of Pennsylvania NIH NHLBI
4R01HL115041-04

Showing 10 of 24 results. Show All Results


Title
Comparative Effectiveness in Gout
Vasculitis Clinical Research Consortium
Low Dose Naltrexone for Chronic Pain in Osteoarthritis and inflammatory Arthritis

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Moran SM, Monach PA, Zgaga L, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Pagnoux C, Seo P, Specks U, Sreih A, Wyse J, Ytterberg SR, Merkel PA, Little MA. Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrol Dial Transplant. 2020 02 01; 35(2):283-291. PMID: 30380100
     
  2. Quinn KA, Gelbard A, Sibley C, Sirajuddin A, Ferrada MA, Chen M, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Pagnoux C, Seo P, Specks U, Sreih AG, Ytterberg SR, Merkel PA, Grayson PC. Subglottic stenosis and endobronchial disease in granulomatosis with polyangiitis. Rheumatology (Oxford). 2019 12 01; 58(12):2203-2211. PMID: 31199488
     
  3. Kronbichler A, Leierer J, Shin JI, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CGM, St Clair EW, Brunetta P, Fervenza FC, Geetha D, Keogh KA, Monach PA, Ytterberg SR, Mayer G, Specks U, Stone JH. Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol. 2019 11; 71(11):1888-1893. PMID: 31216123
     
  4. Wallace ZS, Fu X, Liao K, Kallenberg CGM, Langford CA, Merkel PA, Monach P, Seo P, Specks U, Spiera R, St Clair EW, Zhang Y, Choi H, Stone JH. Disease Activity, Antineutrophil Cytoplasmic Antibody Type, and Lipid Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol. 2019 11; 71(11):1879-1887. PMID: 31162829
     
  5. Rodriguez-Pla A, Warner RL, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland LW, Pagnoux C, Seo P, Specks U, Sreih AG, Ytterberg SR, Johnson KJ, Merkel PA, Monach PA. Evaluation of Potential Serum Biomarkers of Disease Activity in Diverse Forms of Vasculitis. J Rheumatol. 2020 Jul 01; 47(7):1001-1010. PMID: 31474593
     
  6. Gribbons KB, Ponte C, Carette S, Craven A, Cuthbertson D, Hoffman GS, Khalidi NA, Koening CL, Langford CA, Maksimowicz-McKinnon K, McAlear CA, Monach PA, Moreland LW, Pagnoux C, Quinn KA, Robson JC, Seo P, Sreih AG, Suppiah R, Warrington KJ, Ytterberg SR, Luqmani R, Watts R, Merkel PA, Grayson PC. Patterns of Arterial Disease in Takayasu's Arteritis and Giant Cell Arteritis. Arthritis Care Res (Hoboken). 2019 Aug 23. PMID: 31444857
     
  7. Berti A, Warner R, Johnson K, Cornec D, Schroeder DR, Kabat BF, Langford CA, Kallenberg CGM, Seo P, Spiera RF, St Clair EW, Fervenza FC, Stone JH, Monach PA, Specks U, Merkel PA. The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis. J Autoimmun. 2019 12; 105:102302. PMID: 31320177
     
  8. Tomasson G, Farrar JT, Cuthbertson D, McAlear CA, Ashdown S, Cronholm PF, Dawson J, Gebhart D, Lanier G, Luqmani RA, Milman N, Peck J, Robson JC, Shea JA, Carette S, Khalidi N, Koening CL, Langford CA, Monach PA, Moreland L, Pagnoux C, Specks U, Sreih AG, Ytterberg SR, Merkel PA. Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis. J Rheumatol. 2019 08; 46(8):928-934. PMID: 30824648
     
  9. Pagnoux C, Nair P, Xi Y, Khalidi NA, Carette S, Cuthbertson D, Grayson PC, Koening CL, Langford CA, McAlear CA, Moreland LW, Monach PA, Seo P, Specks U, Sreih AG, Ytterberg SR, Tyrrell PN, Merkel PA. Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma. Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):40-44. PMID: 30652675
     
  10. Sreih AG, Ezzedine R, Leng L, Fan J, Yao J, Reid D, Piecychna M, Carette S, Cuthbertson D, Dellaripa P, Hoffman GS, Khalidi NA, Koening CL, Langford CA, Mahr A, McAlear CA, Maksimowicz-Mckinnon K, Monach PA, Seo P, Specks U, St Clair EW, Stone JH, Ytterberg SR, Edberg J, Merkel PA, Bucala R. Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis. Arthritis Rheumatol. 2018 12; 70(12):2077-2086. PMID: 29953750
     
Showing 10 of 106 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 106 publications over 24 distinct years, with a maximum of 14 publications in 2015 and 2017

YearPublications
19901
19911
19931
19951
19961
19991
20011
20031
20041
20052
20074
20081
20093
20105
20114
20127
201313
20146
201514
20165
201714
201810
20198
20201

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomarkers
Vasculitis

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
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75 E. Newton St Evans Building
Boston MA 02118
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