Irving J. Bigio, PhD
Professor
Boston University College of Engineering
Biomedical Engineering

PhD, University of Michigan at Ann Arbor
MS, University of Michigan at Ann Arbor
BS, University of Michigan at Ann Arbor



Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Gastroenterology

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain
01/01/2022 - 11/30/2026 (Multi-PI)
PI: Irving J. Bigio, PhD
NIH/National Institute on Aging
5R01AG075727-02

Validation of Light Scattering Spectroscopy for Intra-operative Margin Guidance during Oral Cancer Resection
07/07/2020 - 06/30/2025 (Subcontract PI)
Boston Medical Center Corporation NIH NIDCR
5 R01 DE029862-04

Personnel Agreement for Research Services of Irving Bigio
07/01/2022 - 12/31/2022 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Ousama A'Amar
08/01/2022 - 08/31/2022 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of A'Amar Ousama
07/01/2021 - 08/31/2021 (PI)
VA Boston Healthcare System


A swallowed-capsule optical screening tool for histological assessment of the esophagus
09/30/2017 - 08/31/2021 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB025673-03

Personnel Agreement for the Research Services of Ousama A’amar
06/01/2020 - 06/30/2020 (PI)
VA Boston Healthcare System


Personnel Agreement for the Research Services of Irving Bigio
04/01/2020 - 06/30/2020 (PI)
VA Boston Healthcare System


Development of Optical instruments for sensing skin disease
08/01/2016 - 12/31/2019 (PI)
DermaSensor, Inc.


Personnel agreement for research services of Eladio Rodriguez-Diaz
09/01/2018 - 06/30/2019 (PI)
VA Boston Healthcare System


Showing 10 of 26 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain 5R01AG075727-03
2023 Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain 5R01AG075727-02
2022 Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain 1R01AG075727-01
2019 A swallowed-capsule optical screening tool for histological assessment of the esophagus 5R01EB025673-03
2018 A swallowed-capsule optical screening tool for histological assessment of the esophagus 5R01EB025673-02
2017 A swallowed-capsule optical screening tool for histological assessment of the esophagus 1R01EB025673-01
2016 Training Program in Quantitative Biology andPhysiology 4T32GM008764-15 25
2015 Training Program in Quantitative Biology andPhysiology 5T32GM008764-14 25
2014 Training Program in Quantitative Biology andPhysiology 5T32GM008764-13 25
2013 Training Program in Quantitative Biology andPhysiology 5T32GM008764-12 25
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer's disease. Alzheimers Res Ther. 2023 Oct 27; 15(1):185.View Related Profiles. PMID: 37891618; PMCID: PMC10605786; DOI: 10.1186/s13195-023-01331-5;
     
  2. Blanke N, Chang S, Novoseltseva A, Wang H, Boas DA, Bigio IJ. Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy. Biomed Opt Express. 2023 Nov 01; 14(11):5946-5964.View Related Profiles. PMID: 38021128; PMCID: PMC10659784; DOI: 10.1364/BOE.499354;
     
  3. Manolakos D, Patrick G, Geisse JK, Rabinovitz H, Buchanan K, Hoang P, Rodriguez-Diaz E, Bigio IJ, Cognetta AB. Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: A comparative effectiveness study. JAAD Int. 2024 Mar; 14:52-58.View Related Profiles. PMID: 38143790; PMCID: PMC10746496; DOI: 10.1016/j.jdin.2023.08.019;
     
  4. Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive Mechanical and Structural Changes in Anterior Cerebral Arteries with Alzheimer's Disease. Res Sq. 2023 Aug 29.View Related Profiles. PMID: 37693508; PMCID: PMC10491325; DOI: 10.21203/rs.3.rs-3283587/v1;
     
  5. Rodriguez-Diaz E, Kaanan S, Vanley C, Qureshi T, Bigio IJ. Toward optical spectroscopy-guided lung biopsy: Demonstration of tissue-type classification. J Biophotonics. 2021 10; 14(10):e202100132.View Related Profiles. PMID: 34245106
     
  6. Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK. Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy. Dig Dis Sci. 2022 02; 67(2):613-621.View Related Profiles. PMID: 33761089
     
  7. Blanke N, Go V, Rosene DL, Bigio IJ. Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey. Neurophotonics. 2021 Jan; 8(1):015010.View Related Profiles. PMID: 33763502; PMCID: PMC7984970; DOI: 10.1117/1.NPh.8.1.015010;
     
  8. Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303.View Related Profiles. PMID: 33578267; PMCID: PMC7881266; DOI: 10.1016/j.neo.2021.01.005;
     
  9. Raufer S, Idoff C, Zosuls A, Marino G, Blanke N, Bigio IJ, O'Malley JT, Burgess BJ, Nadol JB, Guinan JJ, Nakajima HH. Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion. J Assoc Res Otolaryngol. 2020 04; 21(2):171-182.View Related Profiles. PMID: 32166603; PMCID: PMC7270316; DOI: 10.1007/s10162-020-00748-1;
     
  10. Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochem Photobiol. 2019 11; 95(6):1441-1445.View Related Profiles. PMID: 31287160
     
Showing 10 of 92 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 90 publications over 29 distinct years, with a maximum of 10 publications in 2011

YearPublications
19801
19811
19822
19841
19851
19891
19931
19951
19962
19975
19992
20001
20044
20064
20077
20082
20093
20104
201110
20124
20148
20152
20165
20174
20181
20194
20201
20214
20234

2010 Boston University College of Engineering: Distinguished Lecturer Award
2007 Nobel Prize in Physics: Invited Nominator
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Medical application of optics lasers, and spectroscopy
Biophotonics
Nonlinear optics
Applied spectroscopy
Laser physics
Contact for Mentoring:

44 Cummington St
Boston MA 02215
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