Irving Bigio | Profiles RNS

Irving J. Bigio, PhD

Professor

Boston University College of Engineering

Biomedical Engineering

PhD, University of Michigan at Ann Arbor
MS, University of Michigan at Ann Arbor
BS, University of Michigan at Ann Arbor

Websites

	Biomedical Engineering Faculty
	College of Engineering Faculty
	Biomedical Optics Lab
	The International Society for Optics and Photonics
	LinkedIn
	Google Scholar

ORCID : 0000-0003-4168-1466

Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Gastroenterology

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain
01/01/2022 - 11/30/2026 (Multi-PI)
PI: Irving J. Bigio, PhD
NIH/National Institute on Aging
5R01AG075727-04

Validation of Light Scattering Spectroscopy for Intra-operative Margin Guidance during Oral Cancer Resection
07/07/2020 - 06/30/2025 (Subcontract PI)
Boston Medical Center Corporation NIH NIDCR
5R01DE029862-05

Personnel Agreement for Research Services of Irving Bigio
07/01/2022 - 12/31/2022 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Ousama A'Amar
08/01/2022 - 08/31/2022 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of A'Amar Ousama
07/01/2021 - 08/31/2021 (PI)
VA Boston Healthcare System

A swallowed-capsule optical screening tool for histological assessment of the esophagus
09/30/2017 - 08/31/2021 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R01EB025673-03

Personnel Agreement for the Research Services of Ousama A’amar
06/01/2020 - 06/30/2020 (PI)
VA Boston Healthcare System

Personnel Agreement for the Research Services of Irving Bigio
04/01/2020 - 06/30/2020 (PI)
VA Boston Healthcare System

Development of Optical instruments for sensing skin disease
08/01/2016 - 12/31/2019 (PI)
DermaSensor, Inc.

Personnel agreement for research services of Eladio Rodriguez-Diaz
09/01/2018 - 06/30/2019 (PI)
VA Boston Healthcare System

Showing 10 of 26 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2025	Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain	5R01AG075727-04
2024	Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain	5R01AG075727-03
2023	Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain	5R01AG075727-02
2022	Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain	1R01AG075727-01
2019	A swallowed-capsule optical screening tool for histological assessment of the esophagus	5R01EB025673-03
2018	A swallowed-capsule optical screening tool for histological assessment of the esophagus	5R01EB025673-02
2017	A swallowed-capsule optical screening tool for histological assessment of the esophagus	1R01EB025673-01
2016	Training Program in Quantitative Biology andPhysiology	4T32GM008764-15	25
2015	Training Program in Quantitative Biology andPhysiology	5T32GM008764-14	25
2014	Training Program in Quantitative Biology andPhysiology	5T32GM008764-13	25

Showing 10 of 29 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography. Light Sci Appl. 2025 Jan 20; 14(1):57.View Related Profiles.

McKee, Ann
Boas, David
Rosene, Douglas
Bigio, Irving

PMID: 39833166; PMCID: PMC11746934; DOI: 10.1038/s41377-024-01658-0;

Sakharkar M, Spokas G, Berry L, Daniels K, Nithagon P, Rodriguez-Diaz E, Tracy L, Noordzij JP, Bigio I, Grillone G, Krisciunas GP. Non-invasive screening for laryngeal cancer using the oral cavity as a proxy for differentiation of laryngeal cancer versus leukoplakia: A novel application of ESS technology and artificial intelligence supported statistical modeling. Am J Otolaryngol. 2025; 46(1):104581.View Related Profiles.

Krisciunas, Gintas
Grillone, Gregory
Bigio, Irving
Noordzij, J.
Tracy, Lauren
Sakharkar, Mitali

PMID: 39742670; PMCID: PMC11825272; DOI: 10.1016/j.amjoto.2024.104581;

Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Res Sq. 2024 Mar 21.View Related Profiles.

McKee, Ann
Boas, David
Rosene, Douglas
Bigio, Irving

PMID: 38562721; PMCID: PMC10984089; DOI: 10.21203/rs.3.rs-4014687/v1;

Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer's disease. Alzheimers Res Ther. 2023 Oct 27; 15(1):185.View Related Profiles.

Bigio, Irving
Zaia, Joseph
Stein, Thor

PMID: 37891618; PMCID: PMC10605786; DOI: 10.1186/s13195-023-01331-5;

Blanke N, Chang S, Novoseltseva A, Wang H, Boas DA, Bigio IJ. Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy. Biomed Opt Express. 2023 Nov 01; 14(11):5946-5964.View Related Profiles.

Boas, David
Bigio, Irving

PMID: 38021128; PMCID: PMC10659784; DOI: 10.1364/BOE.499354;

Manolakos D, Patrick G, Geisse JK, Rabinovitz H, Buchanan K, Hoang P, Rodriguez-Diaz E, Bigio IJ, Cognetta AB. Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: A comparative effectiveness study. JAAD Int. 2024 Mar; 14:52-58.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 38143790; PMCID: PMC10746496; DOI: 10.1016/j.jdin.2023.08.019;

Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive Mechanical and Structural Changes in Anterior Cerebral Arteries with Alzheimer's Disease. Res Sq. 2023 Aug 29.View Related Profiles.

Bigio, Irving
Zaia, Joseph
Stein, Thor

PMID: 37693508; PMCID: PMC10491325; DOI: 10.21203/rs.3.rs-3283587/v1;

Rodriguez-Diaz E, Kaanan S, Vanley C, Qureshi T, Bigio IJ. Toward optical spectroscopy-guided lung biopsy: Demonstration of tissue-type classification. J Biophotonics. 2021 10; 14(10):e202100132.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 34245106

Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK. Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy. Dig Dis Sci. 2022 02; 67(2):613-621.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving
Singh, Satish

PMID: 33761089

Blanke N, Go V, Rosene DL, Bigio IJ. Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey. Neurophotonics. 2021 Jan; 8(1):015010.View Related Profiles.

Rosene, Douglas
Bigio, Irving
Go, Veronica

PMID: 33763502; PMCID: PMC7984970; DOI: 10.1117/1.NPh.8.1.015010;

Showing 10 of 95 results. Show More

Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303.View Related Profiles.

Roblyer, Darren
Waxman, David
Bigio, Irving

PMID: 33578267; PMCID: PMC7881266; DOI: 10.1016/j.neo.2021.01.005;

Raufer S, Idoff C, Zosuls A, Marino G, Blanke N, Bigio IJ, O'Malley JT, Burgess BJ, Nadol JB, Guinan JJ, Nakajima HH. Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion. J Assoc Res Otolaryngol. 2020 04; 21(2):171-182.View Related Profiles.

Zosuls, Aleksandrs
Bigio, Irving

PMID: 32166603; PMCID: PMC7270316; DOI: 10.1007/s10162-020-00748-1;

Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochem Photobiol. 2019 11; 95(6):1441-1445.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 31287160

Belghasem ME, A'amar O, Roth D, Walker J, Arinze N, Richards SM, Francis JM, Salant DJ, Chitalia VC, Bigio IJ. Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy. Sci Rep. 2019 05 09; 9(1):7168.View Related Profiles.

Roth, Daniel
Salant, David
Bigio, Irving
Francis, Jean
Walker, Joshua
Belghasem, Mostafa
Arinze , Nkiruka
Chitalia, Vipul

PMID: 31073168; PMCID: PMC6509114; DOI: 10.1038/s41598-019-43684-8;

Sharaha U, Rodriguez-Diaz E, Sagi O, Riesenberg K, Salman A, Bigio IJ, Huleihel M. Fast and reliable determination of Escherichia coli susceptibility to antibiotics: Infrared microscopy in tandem with machine learning algorithms. J Biophotonics. 2019 07; 12(7):e201800478.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 30916881

Sharaha U, Rodriguez-Diaz E, Sagi O, Riesenberg K, Lapidot I, Segal Y, Bigio IJ, Huleihel M, Salman A. Detection of Extended-Spectrum ß-Lactamase-Producing Escherichia coli Using Infrared Microscopy and Machine-Learning Algorithms. Anal Chem. 2019 02 05; 91(3):2525-2530.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 30681832

Zhu Y, Fearn T, Chicken DW, Austwick MR, Somasundaram SK, Mosse CA, Clark B, Bigio IJ, Keshtgar MRS, Bown SG. Elastic scattering spectroscopy for early detection of breast cancer: partially supervised Bayesian image classification of scanned sentinel lymph nodes. J Biomed Opt. 2018 08; 23(8):1-9. PMID: 30132305; PMCID: PMC8357191; DOI: 10.1117/1.JBO.23.8.085004;

Sharaha U, Rodriguez-Diaz E, Riesenberg K, Bigio IJ, Huleihel M, Salman A. Using Infrared Spectroscopy and Multivariate Analysis to Detect Antibiotics' Resistant Escherichia coli Bacteria. Anal Chem. 2017 09 05; 89(17):8782-8790.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 28731324

Grillone GA, Wang Z, Krisciunas GP, Tsai AC, Kannabiran VR, Pistey RW, Zhao Q, Rodriguez-Diaz E, A'Amar OM, Bigio IJ. The color of cancer: Margin guidance for oral cancer resection using elastic scattering spectroscopy. Laryngoscope. 2017 Sep; 127 Suppl 4:S1-S9.View Related Profiles.

Rodriguez-Diaz, Eladio
Krisciunas, Gintas
Grillone, Gregory
Bigio, Irving
Zhao, Qing
Pistey, Robert

PMID: 28752518; PMCID: PMC5568964; DOI: 10.1002/lary.26763;

Salman A, Sharaha U, Rodriguez-Diaz E, Shufan E, Riesenberg K, Bigio IJ, Huleihel M. Detection of antibiotic resistant Escherichia Coli bacteria using infrared microscopy and advanced multivariate analysis. Analyst. 2017 Jun 12; 142(12):2136-2144.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 28518194

Nguyen J, Hossain SS, Cooke JRN, Ellis JA, Deci MB, Emala CW, Bruce JN, Bigio IJ, Straubinger RM, Joshi S. Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas. J Neurooncol. 2017 May; 133(1):77-85. PMID: 28421460; DOI: 10.1007/s11060-017-2429-5;

Angelo J, Vargas CR, Lee BT, Bigio IJ, Gioux S. Ultrafast optical property map generation using lookup tables. J Biomed Opt. 2016 11 01; 21(11):110501. PMID: 27901550; PMCID: PMC5997006; DOI: 10.1117/1.JBO.21.11.110501;

Ellis JA, Cooke J, Singh-Moon RP, Wang M, Bruce JN, Emala CW, Bigio IJ, Joshi S. Safety, feasibility, and optimization of intra-arterial mitoxantrone delivery to gliomas. J Neurooncol. 2016 Dec; 130(3):449-454. PMID: 27576697

Joshi S, Cooke JR, Chan DK, Ellis JA, Hossain SS, Singh-Moon RP, Wang M, Bigio IJ, Bruce JN, Straubinger RM. Liposome size and charge optimization for intraarterial delivery to gliomas. Drug Deliv Transl Res. 2016 Jun; 6(3):225-33. PMID: 27091339; PMCID: PMC5508862; DOI: 10.1007/s13346-016-0294-y;

Badreddine AH, Jordan T, Bigio IJ. Real-time imaging of action potentials in nerves using changes in birefringence. Biomed Opt Express. 2016 May 1; 7(5):1966-73. PMID: 27231635; PMCID: PMC4871095; DOI: 10.1364/BOE.7.001966;

Nguyen J, Cooke JRN, Ellis JA, Deci M, Emala CW, Bruce JN, Bigio IJ, Straubinger RM, Joshi S. Cationizable lipid micelles as vehicles for intraarterial glioma treatment. J Neurooncol. 2016 May; 128(1):21-28. PMID: 26903015; PMCID: PMC4865417; DOI: 10.1007/s11060-016-2088-y;

Badreddine AH, Schoener KJ, Bigio IJ. Elucidating the temporal dynamics of optical birefringence changes in crustacean nerves. Biomed Opt Express. 2015 Oct 1; 6(10):4165-78. PMID: 26504663; PMCID: PMC4605072; DOI: 10.1364/BOE.6.004165;

Joshi S, Singh-Moon RP, Ellis JA, Chaudhuri DB, Wang M, Reif R, Bruce JN, Bigio IJ, Straubinger RM. Cerebral hypoperfusion-assisted intra-arterial deposition of liposomes in normal and glioma-bearing rats. Neurosurgery. 2015 Jan; 76(1):92-100. PMID: 25525695; PMCID: PMC4273869; DOI: 10.1227/NEU.0000000000000552;

Rodriguez-Diaz E, Huang Q, Cerda SR, O'Brien MJ, Bigio IJ, Singh SK. Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy. Gastrointest Endosc. 2015 Mar; 81(3):539-47.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving
O'Brien, Michael
Cerda, Sandra
Singh, Satish

PMID: 25257128; PMCID: PMC5533077; DOI: 10.1016/j.gie.2014.07.012;

Joshi S, Singh-Moon R, Wang M, Chaudhuri DB, Ellis JA, Bruce JN, Bigio IJ, Straubinger RM. Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection. J Neurooncol. 2014 Dec; 120(3):489-97. PMID: 25195130; PMCID: PMC4237707; DOI: 10.1007/s11060-014-1584-1;

Singh-Moon RP, Roblyer DM, Bigio IJ, Joshi S. Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging. J Biomed Opt. 2014 Sep; 19(9):96003.View Related Profiles.

Roblyer, Darren
Bigio, Irving

PMID: 25199058; PMCID: PMC4157604; DOI: 10.1117/1.JBO.19.9.096003;

Rodriguez-Diaz E, Atkinson C, Jepeal LI, Berg A, Huang CS, Cerda SR, O'Brien MJ, Bigio IJ, Farraye FA, Singh SK. Elastic scattering spectroscopy as an optical marker of inflammatory bowel disease activity and subtypes. Inflamm Bowel Dis. 2014 Jun; 20(6):1029-36.View Related Profiles.

Huang, Christopher
Rodriguez-Diaz, Eladio
Farraye, Francis
Bigio, Irving
O'Brien, Michael
Cerda, Sandra
Singh, Satish

PMID: 24798637; PMCID: PMC4858439; DOI: 10.1097/MIB.0000000000000058;

Joshi S, Singh-Moon RP, Wang M, Chaudhuri DB, Holcomb M, Straubinger NL, Bruce JN, Bigio IJ, Straubinger RM. Transient cerebral hypoperfusion assisted intraarterial cationic liposome delivery to brain tissue. J Neurooncol. 2014 May; 118(1):73-82. PMID: 24664370; PMCID: PMC4038763; DOI: 10.1007/s11060-014-1421-6;

Joshi S, Singh-Moon R, Wang M, Bruce JN, Bigio IJ, Mayevsky A. Real-time hemodynamic response and mitochondrial function changes with intracarotid mannitol injection. Brain Res. 2014 Feb 26; 1549:42-51. PMID: 24440631; PMCID: PMC4035226; DOI: 10.1016/j.brainres.2013.12.036;

Calabro KW, Bigio IJ. Influence of the phase function in generalized diffuse reflectance models: review of current formalisms and novel observations. J Biomed Opt. 2014; 19(7):75005. PMID: 25027000; PMCID: PMC4161006; DOI: 10.1117/1.JBO.19.7.075005;

Angelo J, Venugopal V, Fantoni F, Poher V, Bigio IJ, Herve L, Dinten JM, Gioux S. Depth-enhanced fluorescence imaging using masked detection of structured illumination. J Biomed Opt. 2014; 19(11):116008. PMID: 25396713; PMCID: PMC4407767; DOI: 10.1117/1.JBO.19.11.116008;

A'Amar OM, Liou L, Rodriguez-Diaz E, De las Morenas A, Bigio IJ. Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment. Lasers Med Sci. 2013 Sep; 28(5):1323-9.View Related Profiles.

De Las Morenas, Antonio
Rodriguez-Diaz, Eladio
Bigio, Irving

PMID: 23247663; DOI: 10.1007/s10103-012-1245-6;

Bigio IJ. Real-time pathology to guide breast surgery: seeing alone is not believing. Clin Cancer Res. 2012 Nov 15; 18(22):6083-5. PMID: 23052257; PMCID: PMC3500420; DOI: 10.1158/1078-0432.CCR-12-2823;

Ergin A, Wang M, Zhang J, Bigio I, Joshi S. Noninvasive in vivo optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits. J Biomed Opt. 2012 May; 17(5):057008. PMID: 22612147; PMCID: PMC3381026; DOI: 10.1117/1.JBO.17.5.057008;

Hillman EM, Elson DS, Bigio IJ, Levenson RM, So PT. Advances in optics for biotechnology, medicine and surgery. Biomed Opt Express. 2012 Mar 1; 3(3):531-2. PMID: 22435099; PMCID: PMC3296539; DOI: 10.1364/BOE.3.000531;

Curtis A, Calabro K, Galarneau JR, Bigio IJ, Krucker T. Temporal variations of skin pigmentation in C57BL/6 mice affect optical bioluminescence quantitation. Mol Imaging Biol. 2011 Dec; 13(6):1114-23. PMID: 20960234; PMCID: PMC3210941; DOI: 10.1007/s11307-010-0440-8;

Mulvey CS, Zhang K, Liu WH, Waxman DJ, Bigio IJ. Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures. J Biomed Opt. 2011 Nov; 16(11):117001.View Related Profiles.

Mulvey, Christine
Waxman, David
Bigio, Irving

PMID: 22112133; PMCID: PMC3221717; DOI: 10.1117/1.3644389;

Mulvey CS, Zhang K, Bobby Liu WH, Waxman DJ, Bigio IJ. Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 2: early spectral changes during apoptosis are linked to apoptotic volume decrease. J Biomed Opt. 2011 Nov; 16(11):117002.View Related Profiles.

Mulvey, Christine
Waxman, David
Bigio, Irving

PMID: 22112134; PMCID: PMC3221718; DOI: 10.1117/1.3644911;

Ergin A, Wang M, Zhang JY, Bruce JN, Fine RL, Bigio IJ, Joshi S. The feasibility of real-time in vivo optical detection of blood-brain barrier disruption with indocyanine green. J Neurooncol. 2012 Feb; 106(3):551-60. PMID: 21964696; DOI: 10.1007/s11060-011-0711-5;

Joshi S, Reif R, Wang M, Zhang J, Ergin A, Bruce JN, Fine RL, Bigio IJ. Intra-arterial mitoxantrone delivery in rabbits: an optical pharmacokinetic study. Neurosurgery. 2011 Sep; 69(3):706-12; discussion 712. PMID: 21430588; PMCID: PMC4028021; DOI: 10.1227/NEU.0b013e3182181b67;

Jerjes WK, Upile T, Wong BJ, Betz CS, Sterenborg HJ, Witjes MJ, Berg K, van Veen R, Biel MA, El-Naggar AK, Mosse CA, Olivo M, Richards-Kortum R, Robinson DJ, Rosen J, Yodh AG, Kendall C, Ilgner JF, Amelink A, Bagnato V, Barr H, Bolotine L, Bigio I, Chen Z, Choo-Smith LP, D'Cruz AK, Gillenwater A, Leunig A, MacRobert AJ, McKenzie G, Sandison A, Soo KC, Stepp H, Stone N, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Hopper C. The future of medical diagnostics: review paper. Head Neck Oncol. 2011; 3:38. PMID: 21861912; PMCID: PMC3180646; DOI: 10.1186/1758-3284-3-38;

Rodriguez-Diaz E, Castanon DA, Singh SK, Bigio IJ. Spectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia. J Biomed Opt. 2011 Jun; 16(6):067009.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving
Singh, Satish

PMID: 21721830; PMCID: PMC3133803; DOI: 10.1117/1.3592488;

Rodriguez-Diaz E, Bigio IJ, Singh SK. INTEGRATED OPTICAL TOOLS FOR MINIMALLY INVASIVE DIAGNOSIS AND TREATMENT AT GASTROINTESTINAL ENDOSCOPY. Robot Comput Integr Manuf. 2011 Apr 01; 27(2):249-256.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving
Singh, Satish

PMID: 21152112; PMCID: PMC2997708; DOI: 10.1016/j.rcim.2010.06.006;

Upile T, Jerjes WK, Sterenborg HJ, Wong BJ, El-Naggar AK, Ilgner JF, Sandison A, Witjes MJ, Biel MA, van Veen R, Hamdoon Z, Gillenwater A, Mosse CA, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Barr H, Chen Z, Berg K, D'Cruz AK, Sudhoff H, Stone N, Kendall C, Fisher S, MacRobert AJ, Leunig A, Olivo M, Richards-Kortum R, Soo KC, Bagnato V, Choo-Smith LP, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Bigio I, Yodh AG, Hopper C. At the frontiers of surgery: review. Head Neck Oncol. 2011; 3(1):7. PMID: 21306627; PMCID: PMC3048561; DOI: 10.1186/1758-3284-3-7;

Calabro K, Curtis A, Galarneau JR, Krucker T, Bigio IJ. Gender variations in the optical properties of skin in murine animal models. J Biomed Opt. 2011 Jan-Feb; 16(1):011008. PMID: 21280895; DOI: 10.1117/1.3525565;

Suh H, A'amar O, Rodriguez-Diaz E, Lee S, Bigio I, Rosen JE. Elastic light-scattering spectroscopy for discrimination of benign from malignant disease in thyroid nodules. Ann Surg Oncol. 2011 May; 18(5):1300-5.View Related Profiles.

Rodriguez-Diaz, Eladio
Bigio, Irving
Rosen, Jennifer
Lee, Stephanie

PMID: 21174158; DOI: 10.1245/s10434-010-1452-y;

Joshi S, Ergin A, Wang M, Reif R, Zhang J, Bruce JN, Bigio IJ. Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy. J Neurooncol. 2011 Aug; 104(1):11-9. PMID: 21153681; PMCID: PMC4013427; DOI: 10.1007/s11060-010-0466-4;

Keshtgar MR, Chicken DW, Austwick MR, Somasundaram SK, Mosse CA, Zhu Y, Bigio IJ, Bown SG. Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer. Br J Surg. 2010 Aug; 97(8):1232-9. PMID: 20593429; DOI: 10.1002/bjs.7095;

Austwick MR, Clark B, Mosse CA, Johnson K, Chicken DW, Somasundaram SK, Calabro KW, Zhu Y, Falzon M, Kocjan G, Fearn T, Bown SG, Bigio IJ, Keshtgar MR. Scanning elastic scattering spectroscopy detects metastatic breast cancer in sentinel lymph nodes. J Biomed Opt. 2010 Jul-Aug; 15(4):047001. PMID: 20799832; PMCID: PMC2917446; DOI: 10.1117/1.3463005;

Mulvey CS, Sherwood CA, Bigio IJ. Wavelength-dependent backscattering measurements for quantitative real-time monitoring of apoptosis in living cells. J Biomed Opt. 2009 Nov-Dec; 14(6):064013.View Related Profiles.

Mulvey, Christine
Bigio, Irving

PMID: 20059251; PMCID: PMC2794414; DOI: 10.1117/1.3259363;

Upile T, Jerjes W, Sterenborg HJ, El-Naggar AK, Sandison A, Witjes MJ, Biel MA, Bigio I, Wong BJ, Gillenwater A, MacRobert AJ, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Mosse CA, Barr H, Chen Z, Berg K, D'Cruz AK, Stone N, Kendall C, Fisher S, Leunig A, Olivo M, Richards-Kortum R, Soo KC, Bagnato V, Choo-Smith LP, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Yodh AG, Hopper C. Head & neck optical diagnostics: vision of the future of surgery. Head Neck Oncol. 2009; 1:25. PMID: 19594907; PMCID: PMC2720388; DOI: 10.1186/1758-3284-1-25;

Zhu Y, Fearn T, Mackenzie G, Clark B, Dunn JM, Bigio IJ, Bown SG, Lovat LB. Elastic scattering spectroscopy for detection of cancer risk in Barrett's esophagus: experimental and clinical validation of error removal by orthogonal subtraction for increasing accuracy. J Biomed Opt. 2009 Jul-Aug; 14(4):044022. PMID: 19725733; PMCID: PMC2849300; DOI: 10.1117/1.3194291;

Georgescu R, Khismatullin D, Holt RG, Castagner JL, A'amar O, Bigio IJ. Design of a system to measure light scattering from individual cells excited by an acoustic wave. Opt Express. 2008 Mar 17; 16(6):3496-503. PMID: 18542442

Reif R, Amorosino MS, Calabro KW, A'Amar O, Singh SK, Bigio IJ. Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures. J Biomed Opt. 2008 Jan-Feb; 13(1):010502.View Related Profiles.

Bigio, Irving
Singh, Satish

PMID: 18315347; DOI: 10.1117/1.2870115;

Itzkan I, Qiu L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell M, Andersson C, Kimerer LM, Cipolloni PB, Lim KH, Freedman SD, Bigio I, Sachs BP, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17255-60.View Related Profiles.

Bigio, Irving
Cipolloni, Patsy

PMID: 17956980; PMCID: PMC2077242; DOI: 10.1073/pnas.0708669104;

Reif R, A'Amar O, Bigio IJ. Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media. Appl Opt. 2007 Oct 10; 46(29):7317-28. PMID: 17932546

Bigio IJ, Singh SK. Gastrointestinal cancer surveillance by optical sensing. Clin Cancer Res. 2007 Aug 1; 13(15 Pt 1):4315-6.View Related Profiles.

Bigio, Irving
Singh, Satish

PMID: 17671109

Reif R, Wang M, Joshi S, A'Amar O, Bigio IJ. Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue. J Biomed Opt. 2007 May-Jun; 12(3):034036. PMID: 17614744

Fang H, Qiu L, Vitkin E, Zaman MM, Andersson C, Salahuddin S, Kimerer LM, Cipolloni PB, Modell MD, Turner BS, Keates SE, Bigio I, Itzkan I, Freedman SD, Bansil R, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy. Appl Opt. 2007 Apr 1; 46(10):1760-9.View Related Profiles.

Bigio, Irving
Cipolloni, Patsy
Bansil, Rama

PMID: 17356619

Castagner JL, Bigio IJ. Particle sizing with a fast polar nephelometer. Appl Opt. 2007 Feb 1; 46(4):527-32. PMID: 17230246

Kelloff GJ, Sullivan DC, Baker H, Clarke LP, Nordstrom R, Tatum JL, Dorfman GS, Jacobs P, Berg CD, Pomper MG, Birrer MJ, Tempero M, Higley HR, Petty BG, Sigman CC, Maley C, Sharma P, Wax A, Ginsberg GG, Dannenberg AJ, Hawk ET, Messing EM, Grossman HB, Harisinghani M, Bigio IJ, Griebel D, Henson DE, Fabian CJ, Ferrara K, Fantini S, Schnall MD, Zujewski JA, Hayes W, Klein EA, DeMarzo A, Ocak I, Ketterling JA, Tempany C, Shtern F, Parnes HL, Gomez J, Srivastava S, Szabo E, Lam S, Seibel EJ, Massion P, McLennan G, Cleary K, Suh R, Burt RW, Pfeiffer RM, Hoffman JM, Roy HK, Wang T, Limburg PJ, El-Deiry WS, Papadimitrakopoulou V, Hittelman WN, MacAulay C, Veltri RW, Solomon D, Jeronimo J, Richards-Kortum R, Johnson KA, Viner JL, Stratton SP, Rajadhyaksha M, Dhawan A. Workshop on imaging science development for cancer prevention and preemption. Cancer Biomark. 2007; 3(1):1-33.View Related Profiles.

Roy, Hemant
Bigio, Irving

PMID: 17655039

Castagner JL, Bigio IJ. Polar nephelometer based on a rotational confocal imaging setup. Appl Opt. 2006 Apr 1; 45(10):2232-9. PMID: 16607989

Sharwani A, Jerjes W, Salih V, Swinson B, Bigio IJ, El-Maaytah M, Hopper C. Assessment of oral premalignancy using elastic scattering spectroscopy. Oral Oncol. 2006 Apr; 42(4):343-9. PMID: 16321565

Lovat LB, Johnson K, Mackenzie GD, Clark BR, Novelli MR, Davies S, O'Donovan M, Selvasekar C, Thorpe SM, Pickard D, Fitzgerald R, Fearn T, Bigio I, Bown SG. Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus. Gut. 2006 Aug; 55(8):1078-83. PMID: 16469795; PMCID: PMC1856278; DOI: 10.1136/gut.2005.081497;

Dhar A, Johnson KS, Novelli MR, Bown SG, Bigio IJ, Lovat LB, Bloom SL. Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique. Gastrointest Endosc. 2006 Feb; 63(2):257-61. PMID: 16427931

A'Amar OM, Ley RD, Bigio IJ. Comparison between ultraviolet-visible and near-infrared elastic scattering spectroscopy of chemically induced melanomas in an animal model. J Biomed Opt. 2004 Nov-Dec; 9(6):1320-6. PMID: 15568954

Johnson KS, Chicken DW, Pickard DC, Lee AC, Briggs G, Falzon M, Bigio IJ, Keshtgar MR, Bown SG. Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast. J Biomed Opt. 2004 Nov-Dec; 9(6):1122-8. PMID: 15568931

Chicken DW, Johnson KS, Falzon MR, Lee AC, Briggs G, Pickard D, Bigio IJ, Bown SG, Keshtgar MR. Optical biopsy utilising elastic scattering spectroscopy for intra-operative diagnosis of sentinel lymph node metastases. J Clin Oncol. 2004 Jul 15; 22(14_suppl):841. PMID: 28014227

Bigio IJ, Bown SG. Spectroscopic sensing of cancer and cancer therapy: current status of translational research. Cancer Biol Ther. 2004 Mar; 3(3):259-67. PMID: 15107613

Bigio IJ, Bown SG, Briggs G, Kelley C, Lakhani S, Pickard D, Ripley PM, Rose IG, Saunders C. Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. J Biomed Opt. 2000 Apr; 5(2):221-8. PMID: 10938787

Bigio IJ, Mourant JR, Los G. Noninvasive, in-situ measurement of drug concentrations in tissue using optical spectroscopy. J Gravit Physiol. 1999 Jul; 6(1):P173-5. PMID: 11543008

Mourant JR, Johnson TM, Los G, Bigio IJ. Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements. Phys Med Biol. 1999 May; 44(5):1397-417. PMID: 10368027

Hielscher A, Eick A, Mourant J, Shen D, Freyer J, Bigio I. Diffuse backscattering Mueller matricesof highly scattering media. Opt Express. 1997 Dec 22; 1(13):441-53. PMID: 19377568

Mourant JR, Bigio IJ, Jack DA, Johnson TM, Miller HD. Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties. Appl Opt. 1997 Aug 1; 36(22):5655-61. PMID: 18259392

Bigio IJ, Mourant JR. Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy. Phys Med Biol. 1997 May; 42(5):803-14. PMID: 9172260

Mourant JR, Fuselier T, Boyer J, Johnson TM, Bigio IJ. Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms. Appl Opt. 1997 Feb 1; 36(4):949-57. PMID: 18250760

Hielscher AH, Mourant JR, Bigio IJ. Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions. Appl Opt. 1997 Jan 1; 36(1):125-35. PMID: 18250653

Mourant JR, Boyer J, Hielscher AH, Bigio IJ. Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separations. Opt Lett. 1996 Apr 1; 21(7):546-8. PMID: 19865467

Mourant JR, Bigio IJ, Boyer JD, Johnson TM, Lacey J, Bohorfoush Iii AG, Mellow MH. Elastic scattering spectroscopy as a diagnostic tool for differentiating pathologies in the gastrointestinal tract: preliminary testing. J Biomed Opt. 1996 Apr; 1(2):192-9. PMID: 23014685

Mourant JR, Bigio IJ, Boyer J, Conn RL, Johnson T, Shimada T. Spectroscopic diagnosis of bladder cancer with elastic light scattering. Lasers Surg Med. 1995; 17(4):350-7. PMID: 8684237

Bigio IJ, Gosnell TR, Mukherjee P, Safer JD. Microwave absorption spectroscopy of DNA. Biopolymers. 1993 Jan; 33(1):147-50. PMID: 8427931

Scott AC, Bigio IJ, Johnston CT. Polarons in acetanilide. Phys Rev B Condens Matter. 1989 Jun 15; 39(17):12883-12887. PMID: 9948162

Layne SP, Bigio IJ, Scott AC, Lomdahl PS. Transient fluorescence in synchronously dividing Escherichia coli. Proc Natl Acad Sci U S A. 1985 Nov; 82(22):7599-603. PMID: 3906649; PMCID: PMC391380

Slatkine M, Bigio IJ. Quenching of backward stimulated Raman scattering by broadband forward Raman radiation. Opt Lett. 1984 Jul 1; 9(7):294-6. PMID: 19721575

Slatkine M, Bigio IJ, Feldman BJ, Fisher RA. Efficient phase conjugation of an ultraviolet XeF laser beam by stimulated Brillouin scattering. Opt Lett. 1982 Mar 1; 7(3):108-10. PMID: 19710839

Bigio IJ, Slatkine M. Transform-limited-bandwidth injection locking of an XeF laser with an Ar-ion laser at 3511 A. Opt Lett. 1982 Jan 1; 7(1):19-21. PMID: 19710809

Bigio IJ, Slatkine M. Attainment of the theoretical minimum input power for injection locking of an unstable-resonator KrF laser. Opt Lett. 1981 Jul 1; 6(7):336-8. PMID: 19701424

Bigio IJ, Jackson SV, Laird A, Seagrave J. Beam-diagnostics techniques for multiterawatt CO(2) lasers. Appl Opt. 1980 Mar 15; 19(6):914-7. PMID: 20220958; DOI: 10.1364/AO.19.000914;

Bergmann EE, Bigio IJ, Feldman BJ, Fisher RA. High-efficiency pulsed 10.6-Mu m phase-conjugate reflection via degenerate four-wave mixing. Opt Lett. 1978 Sep 1; 3(3):82. PMID: 19684704

Bigio IJ, Finn RS, Ward JF. Electric-field induced harmonic generation as a probe of the focal region of a laser beam. Appl Opt. 1975 Feb 1; 14(2):336-42. PMID: 20134889; DOI: 10.1364/AO.14.000336;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 93 publications over 31 distinct years, with a maximum of 10 publications in 2011

Bar chart showing 93 publications over 31 distinct years, with a maximum of 10 publications in 2011

Year	Publications
1980	1
1981	1
1982	2
1984	1
1985	1
1989	1
1993	1
1995	1
1996	2
1997	5
1999	2
2000	1
2004	4
2006	4
2007	7
2008	2
2009	3
2010	4
2011	10
2012	4
2014	8
2015	2
2016	5
2017	4
2018	1
2019	4
2020	1
2021	4
2023	4
2024	2
2025	1