Thomas Perls | Profiles RNS

Thomas T. Perls, MD, MPH, FACP

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Geriatrics

MD, University of Rochester
MPH, Harvard School of Public Health
BA, Pitzer College

Websites

	Boston Medical Center Provider Profile
	New England Centenarian Study
	Living to 100 Life Expectancy Calculator
	Public Relations - BU Experts

ORCID : 0000-0002-2492-4334

Expertise in epidemiology, genetics of aging and exceptional longevity.

Dr. Perls is among the international leaders in the field of human exceptional longevity. He is founder and director of the New England Centenarian Study, the largest study of centenarians and their families in the world. He is also a principal investigator of the NIA-funded Long Life Family Study. Dr. Perls is also a vocal critic of the "anti-aging" industry.

Dr. Perls is readily available for media interviews and inquiries for presentations. Please call him at 617-638-6688 or via email at thperls@bu.edu.

He has been responsible for numerous novel and pivotal findings in the field:

• Intact cognitive function amongst centenarians may be a function of demographic selection in which younger elderly with poor function die off leaving behind a select group of survivors with lower relative risk for common causes of cognitive impairment such as Alzheimer’s disease.

• Twenty percent of female centenarians had children after the age of 40 compared with 5% of women from their birth cohort. The results suggest that women who had children after the age of 40 had a 4 times greater risk of living to 100 or older (Nature).

• Delayed age of menopause and therefore the ability to have more children may be an important genetic selective pressure to evolve genetic variants that slow aging and decrease risk for age related diseases.

• Relative to octogenarians and nonagenarians, Alzheimer’s becomes less common amongst centenarians while rarer causes of neuropathology become more common, suggesting that centenarians have a relative resistance to Alzheimer’s, which also correlates with the decreased frequency of the apolipoprotein E-4 allele amongst Caucasian centenarians.

• The first to report a series of families that demonstrate remarkable clustering for exceptional longevity (J Amer Geriatrics Society).

• Siblings of centenarians have markedly increased risks for survival to 100 relative to their birth cohort (Lancet and PNAS).

• The children of centenarians have approximately 60% reduced rates of heart disease, stroke, diabetes and hypertension and 80% reduced overall mortality in their early seventies compared to their average birth cohort.

• A substantial proportion of centenarians live with age-related diseases usually associated with significant mortality, for more than 20 years (40%, called survivors), another group have such diseases after the age of 80 (45%, called delayers) and then there are about 15% of centenarians who have none of these diseases at the age of 100 (called escapers). Despite this, more than 90% of centenarians are functionally independent in their early nineties.

• At even older ages however, semi-super-centenarians (ages 105-109 years) and even more so, supercentenarians (age 110+), usually delay such age related diseases towards the ends of their lives. The supercentenarians particularly do this, experiencing such diseases on average in the last 5% of their extremely long lives (J Gerontology, 2012). These findings support for the first time Jim Fries’ “compression of morbidity” hypothesis that he proposed in his 1980 New England Journal of Medicine article. The observed homogeneity of this age group in terms of the delay or escape of these diseases is consistent with their being the extreme tail of the population and that they are more likely to have genetic factors in common that confer such an extreme survival advantage.

• Dr. Perls, working with a wide range of disciplines including statisticians, geneticists and computer scientists, has led the production of a landmark article in which a genetic model consisting of 281 genetic markers predicts with 85% accuracy whom in their sample of controls and centenarians is age 105+ years (published this January in PLoS ONE). The accuracy of the model is lower, about 60% for nonagenarians and centenarians at age 100, which supports the hypothesis that the genetic component of survival to older and older age beyond 100 gets progressively stringer. The authors made some additionally important findings: the centenarians have just as many disease-associated genetic variants as people dying at younger ages. Presumably, centenarians are able to survive to much older ages in part because of the presence of longevity associated variants that counter the effects of such disease variants. Particularly for the oldest subjects in the study, most of these 281 markers presumably point to such longevity associated variants, including genes already well known in the biology of aging community such as the Werner’s gene, Lamin A (Hutchison Guildford Syndrome) and super oxide dismutase. It’s very interesting that there are variants for genes known to cause premature aging that may have the opposite effect and contribute to exceptional longevity.

• In part in order to search for functional variants associated with the SNPs noted in the above model, Dr. Perls also led an effort to whole genome sequence, for the first time, not just one centenarian, but two supercentenarians, a man and woman, both over the age of 114 years (Frontiers in Genetics, January 2012).

Expertise in geriatrics, epidemiology and omics of healthy aging, Alzheimer's and exceptional longevity.

Dr. Perls is among the international leaders in the field of human exceptional longevity. He is founder and director of the New England Centenarian Study, the largest study of centenarians and their families in the world. He is also a principal investigator of the NIA-funded Long Life Family Study. Dr. Perls is also a vocal critic of the "anti-aging" industry.

Tom Perls MD, MPH attended Pitzer College in Claremont California and then the University of Rochester School of Medicine for his medical degree and Harvard University School of Public Health for his Masters in Public Health, majoring in Quantitative Methods. He performed his residency in internal medicine at Harbor UCLA Medical Center, a half year registrarship in Geriatrics at Mount Royal Hospital in Melbourne Australia and Clinical-Research Geriatrics Fellowship at Harvard Medical School. He was also an Agency for Health Care Quality Research Fellow at Brown University. After fellowship, Dr. Perls was on the faculty at Beth Israel Deaconess Hospital. Since 2002, he has been based at Chobanian and Avedisian School of Medicine and Boston Medical Center and is Professor of Medicine in the Geriatrics Section of the Department of Medicine.

Dr. Perls is readily available for media interviews and inquiries for presentations. Please call him at 617-638-6688 or via email at thperls@bu.edu.

He has been responsible for numerous novel and pivotal findings in the field:

• Intact cognitive function amongst centenarians may be a function of demographic selection in which younger elderly with poor function die off leaving behind a select group of survivors with lower relative risk for common causes of cognitive impairment such as Alzheimer’s disease.

• Twenty percent of female centenarians had children after the age of 40 compared with 5% of women from their birth cohort. The results suggest that women who had children after the age of 40 had a 4 times greater risk of living to 100 or older (Nature).

• Delayed age of menopause and therefore the ability to have more children may be an important genetic selective pressure to evolve genetic variants that slow aging and decrease risk for age related diseases.

• Relative to octogenarians and nonagenarians, Alzheimer’s becomes less common amongst centenarians while rarer causes of neuropathology become more common, suggesting that centenarians have a relative resistance to Alzheimer’s, which also correlates with the decreased frequency of the apolipoprotein E-4 allele amongst Caucasian centenarians.

• The first to report a series of families that demonstrate remarkable clustering for exceptional longevity (J Amer Geriatrics Society).

• Siblings of centenarians have markedly increased risks for survival to 100 relative to their birth cohort (Lancet and PNAS).

• The children of centenarians have approximately 60% reduced rates of heart disease, stroke, diabetes and hypertension and 80% reduced overall mortality in their early seventies compared to their average birth cohort.

• A substantial proportion of centenarians live with age-related diseases usually associated with significant mortality, for more than 20 years (40%, called survivors), another group have such diseases after the age of 80 (45%, called delayers) and then there are about 15% of centenarians who have none of these diseases at the age of 100 (called escapers). Despite this, more than 90% of centenarians are functionally independent in their early nineties.

• At even older ages however, semi-super-centenarians (ages 105-109 years) and even more so, supercentenarians (age 110+), usually delay such age related diseases towards the ends of their lives. The supercentenarians particularly do this, experiencing such diseases on average in the last 5% of their extremely long lives (J Gerontology, 2012). These findings support for the first time Jim Fries’ “compression of morbidity” hypothesis that he proposed in his 1980 New England Journal of Medicine article. The observed homogeneity of this age group in terms of the delay or escape of these diseases is consistent with their being the extreme tail of the population and that they are more likely to have genetic factors in common that confer such an extreme survival advantage.

• Dr. Perls, working with a wide range of disciplines including statisticians, geneticists and computer scientists, has led the production of a landmark article in which a genetic model consisting of 281 genetic markers predicts with 85% accuracy whom in their sample of controls and centenarians is age 105+ years (published this January in PLoS ONE). The accuracy of the model is lower, about 60% for nonagenarians and centenarians at age 100, which supports the hypothesis that the genetic component of survival to older and older age beyond 100 gets progressively stringer. The authors made some additionally important findings: the centenarians have just as many disease-associated genetic variants as people dying at younger ages. Presumably, centenarians are able to survive to much older ages in part because of the presence of longevity associated variants that counter the effects of such disease variants. Particularly for the oldest subjects in the study, most of these 281 markers presumably point to such longevity associated variants, including genes already well known in the biology of aging community such as the Werner’s gene, Lamin A (Hutchison Guildford Syndrome) and super oxide dismutase. It’s very interesting that there are variants for genes known to cause premature aging that may have the opposite effect and contribute to exceptional longevity.

• In part in order to search for functional variants associated with the SNPs noted in the above model, Dr. Perls also led an effort to whole genome sequence, for the first time, not just one centenarian, but two supercentenarians, a man and woman, both over the age of 114 years (Frontiers in Genetics, January 2012).

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)
09/30/2021 - 08/31/2026 (PI)
NIH/National Institute on Aging
3U19AG073172-03S1

Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies
09/01/2022 - 12/31/2025 (PI)
NIH/National Institute on Aging
5UH3AG064704-04

EXCEL Study
07/01/2022 - 06/30/2025 (PI)
American Federation for Aging Research

The Long Life Family Study
08/15/2019 - 03/31/2025 (Multi-PI)
PI: Thomas T. Perls, MD, MPH, FACP
The Washington University NIH NIA
5U19AG063893-05

Candidate protective factors for age-associated diseases (target discovery) or factors indicative of healthy aging
09/15/2016 - 09/15/2024 (Co-Investigator)
PI: Paola Sebastiani, PhD
Novartis Institutes for BioMedical Research

Protein signatures of APOE and cognitive aging
09/01/2020 - 05/31/2024 (Subcontract PI)
Tufts Medical Center, Inc. NIH NIA
R01AG061844

Longevity Consortium
08/15/2019 - 05/31/2024 (Subcontract PI)
Sutter Bay Hospitals dba California Pacific Medical Center NIH NIA
5U19AG023122-15

Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies
09/15/2019 - 06/30/2022 (PI)
NIH/National Institute on Aging
5UH2AG064704-02

New England Centenarian Study
07/01/2016 - 06/30/2022 (Multi-PI)
PI: Thomas T. Perls, MD, MPH, FACP
The William M. Wood Foundation

The New England Centenarian Study
10/01/2014 - 08/31/2016 (PI)
The William M. Wood Foundation

Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies
09/15/2019 - 12/31/2024 (Multi-PI)
PI: Thomas T. Perls, MD, MPH, FACP
Trustees of Boston University,CRC NIH NIA

Protein signatures of APOE and cognitive aging
06/01/2019 - 05/31/2020 (Multi-PI)
PI: Thomas T. Perls, MD, MPH, FACP
Trustees of Boston University,CRC NIH NIA
5R01AG061844-02

The Long Life Family Study: Boston Field Center
06/01/2014 - 05/31/2020 (Subcontract PI)
PI: Thomas T. Perls, MD, MPH, FACP
National Institute on Aging/NIH/DHHS NIH
2U01 AG023755-09

Longevity Consortium
09/30/2018 - 05/31/2019 (Multi-PI)
PI: Thomas T. Perls, MD, MPH, FACP
California Pacific Medical Center NIH NIA
2U19AG023122-11A1

Centenarian Subjects for the Archon Genomics X Prize Whole Genome
12/08/2011 - 08/31/2016 (PI)
X Prize Foundation

Consortium to Study the Genetics of Longevity
09/30/2011 - 07/31/2016 (PI)
California Pacific Med Ctr Res Inst NIH-NIA

The Long Life Family Study
09/30/2010 - 05/31/2014 (PI)
NIH-NIA
5U01 AG023755-08

The Genetics of Human Exceptional Longevity
07/01/2010 - 06/30/2012 (PI)
Glenn Foundation for Medical Research

Characterizing Human Exceptional Longevity
03/01/2006 - 01/31/2012 (PI)
NIH-NIA
5K24 AG025727-05

Characterizing Human Exceptional Longevity
09/15/2009 - 08/31/2011 (PI)
NIH-NIA
3K24 AG025727-04S1

Showing 10 of 20 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	Administrative Core	5U19AG073172-04-6351
2024	Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)	5U19AG073172-04
2023	Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)	5U19AG073172-03
2023	Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)	3U19AG073172-03S1
2023	Administrative Core	5U19AG073172-03-6351
2023	Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies	5UH3AG064704-04
2023	The Long Life Family Study	3U19AG063893-05S1
2023	Phenotyping Core	5U19AG063893-05-6290
2023	The Long Life Family Study	5U19AG063893-05
2022	Administrative Core	5U19AG073172-02-6959

Showing 10 of 67 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Sebastiani P, Monti S, Lustgarten MS, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Leshchyk A, Short MI, Ardisson Korat AV, Gurinovich A, Karagiannis T, Li M, Lords HJ, Xiang Q, Marron MM, Bae H, Feitosa MF, Wojczynski MK, O'Connell JR, Montasser ME, Schupf N, Arbeev K, Yashin A, Schork N, Christensen K, Andersen SL, Ferrucci L, Rappaport N, Perls TT, Patti GJ. Metabolite signatures of chronological age, aging, survival, and longevity. Cell Rep. 2024 Nov 26; 43(11):114913.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 39504246

Yao S, Boudreau RM, Galvin A, Murabito JM, Honig LS, Perls TT, Christensen K, Newman AB. All-Cause Mortality and Cause-Specific Death in U.S. Long-Lived Siblings: Data From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2024 Nov 01; 79(11).View Related Profiles.

Murabito, Joanne
Perls, Thomas

PMID: 39086360; PMCID: PMC11439495; DOI: 10.1093/gerona/glae190;

Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Milman S, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. Aging Cell. 2024 Sep 25; e14351.View Related Profiles.

Belkina, Anna
Murphy, George
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 39319670; DOI: 10.1111/acel.14351;

Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. Geroscience. 2024 Jul 25.View Related Profiles.

Costello, Catherine
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 39048883

Wang S, Lenzini P, Thygarajan B, Lee JH, Vardarajan BN, Yashin A, Miljkovic I, Warwick Daw E, Lin SJ, Patti G, Brent M, Zmuda JM, Perls TT, Christensen K, Province MA, An P. A Novel Gene ARHGAP44 for Longitudinal Changes in Glycated Hemoglobin (HbA1c) in Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Offspring Study (FOS). bioRxiv. 2024 May 21. PMID: 38826208; PMCID: PMC11142083; DOI: 10.1101/2024.05.16.594575;

Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. bioRxiv. 2024 Apr 14.View Related Profiles.

Costello, Catherine
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 38645061; PMCID: PMC11030369; DOI: 10.1101/2024.04.10.588876;

Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. bioRxiv. 2024 Mar 14.View Related Profiles.

Belkina, Anna
Murphy, George
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 38559230; PMCID: PMC10979955; DOI: 10.1101/2024.03.12.584663;

Don J, Schork AJ, Glusman G, Rappaport N, Cummings SR, Duggan D, Raju A, Hellberg KG, Gunn S, Monti S, Perls T, Lapidus J, Goetz LH, Sebastiani P, Schork NJ. The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. Geroscience. 2024 Aug; 46(4):3911-3927.View Related Profiles.

Sebastiani, Paola
Monti, Stefano
Perls, Thomas

PMID: 38451433; PMCID: PMC11226417; DOI: 10.1007/s11357-024-01107-1;

Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S. Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement. 2024 Apr; 20(4):2670-2679.View Related Profiles.

Andersen, Stacy
Perls, Thomas

PMID: 38380866; PMCID: PMC11032545; DOI: 10.1002/alz.13718;

de Las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, Munroe PB, Miller CL, Aschard H, Aslibekyan S, Bartz TM, Bielak LF, Chai JF, Cheng CY, Dorajoo R, Feitosa MF, Guo X, Hartwig FP, Horimoto A, Kolcic I, Lim E, Liu Y, Manning AK, Marten J, Musani SK, Noordam R, Padmanabhan S, Rankinen T, Richard MA, Ridker PM, Smith AV, Vojinovic D, Zonderman AB, Alver M, Boissel M, Christensen K, Freedman BI, Gao C, Giulianini F, Harris SE, He M, Hsu FC, Kühnel B, Laguzzi F, Li X, Lyytikäinen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Robino A, Sofer T, Takeuchi F, Tayo BO, van der Most PJ, Verweij N, Ware EB, Weiss S, Wen W, Yanek LR, Zhan Y, Amin N, Arking DE, Ballantyne C, Boerwinkle E, Brody JA, Broeckel U, Campbell A, Canouil M, Chai X, Chen YI, Chen X, Chitrala KN, Concas MP, de Faire U, de Mutsert R, de Silva HJ, de Vries PS, Do A, Faul JD, Fisher V, Floyd JS, Forrester T, Friedlander Y, Girotto G, Gu CC, Hallmans G, Heikkinen S, Heng CK, Homuth G, Hunt S, Ikram MA, Jacobs DR, Kavousi M, Khor CC, Kilpeläinen TO, Koh WP, Komulainen P, Langefeld CD, Liang J, Liu K, Liu J, Lohman K, Mägi R, Manichaikul AW, McKenzie CA, Meitinger T, Milaneschi Y, Nauck M, Nelson CP, O'Connell JR, Palmer ND, Pereira AC, Perls T, Peters A, Polašek O, Raitakari OT, Rice K, Rice TK, Rich SS, Sabanayagam C, Schreiner PJ, Shu XO, Sidney S, Sims M, Smith JA, Starr JM, Strauch K, Tai ES, Taylor KD, Tsai MY, Uitterlinden AG, van Heemst D, Waldenberger M, Wang YX, Wei WB, Wilson G, Xuan D, Yao J, Yu C, Yuan JM, Zhao W, Becker DM, Bonnefond A, Bowden DW, Cooper RS, Deary IJ, Divers J, Esko T, Franks PW, Froguel P, Gieger C, Jonas JB, Kato N, Lakka TA, Leander K, Lehtimäki T, Magnusson PKE, North KE, Ntalla I, Penninx B, Samani NJ, Snieder H, Spedicati B, van der Harst P, Völzke H, Wagenknecht LE, Weir DR, Wojczynski MK, Wu T, Zheng W, Zhu X, Bouchard C, Chasman DI, Evans MK, Fox ER, Gudnason V, Hayward C, Horta BL, Kardia SLR, Krieger JE, Mook-Kanamori DO, Peyser PA, Province MM, Psaty BM, Rudan I, Sim X, Smith BH, van Dam RM, van Duijn CM, Wong TY, Arnett DK, Rao DC, Gauderman J, Liu CT, Morrison AC, Rotter JI, Fornage M. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. Front Genet. 2023; 14:1235337.View Related Profiles.

Liu, Ching-Ti
Perls, Thomas

PMID: 38028628; PMCID: PMC10651736; DOI: 10.3389/fgene.2023.1235337;

Showing 10 of 203 results. Show More

Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic Chromosomal Alterations and Human Longevity. J Gerontol A Biol Sci Med Sci. 2023 Aug 27; 78(9):1561-1568.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 36988570; PMCID: PMC10460554; DOI: 10.1093/gerona/glad095;

Milman S, Barzilai N, Wilson KA, Van der Willik O, Lederman S, Perls T, Gao T, Leahy AM, Jain P, Montgomery A, Shuldiner AR. SuperAger Initiative: unlocking the genetic potential of exceptional longevity. Nat Aging. 2023 Jun; 3(6):627-628. PMID: 37202472

Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity. EBioMedicine. 2023 Apr; 90:104514.View Related Profiles.

Belkina, Anna
Murphy, George
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 37005201; PMCID: PMC10114155; DOI: 10.1016/j.ebiom.2023.104514;

Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic chromosomal alterations and human longevity. J Gerontol A Biol Sci Med Sci. 2023 Mar 29.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 36988570; PMCID: PMC10460554; DOI: 10.1093/gerona/glad095;

Perls T. Successful aging and its subtypes in centenarians: The Chinese experience. J Am Geriatr Soc. 2023 May; 71(5):1362-1364. PMID: 36810715; PMCID: PMC10175185; DOI: 10.1111/jgs.18282;

Song Z, Gurinovich A, Nygaard M, Mengel-From J, Andersen S, Cosentino S, Schupf N, Lee J, Zmuda J, Ukraintseva S, Arbeev K, Christensen K, Perls T, Sebastiani P. Rare genetic variants correlate with better processing speed. Neurobiol Aging. 2023 May; 125:115-122.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 36813607; PMCID: PMC10038891; DOI: 10.1016/j.neurobiolaging.2022.11.018;

Xiang Q, Andersen SL, Sweigart B, Gunn S, Nygaard M, Perls TT, Sebastiani P. Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis. J Alzheimers Dis. 2023; 93(4):1457-1469.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 37212095; PMCID: PMC10635779; DOI: 10.3233/JAD-221025;

Bae H, Gurinovich A, Karagiannis TT, Song Z, Leshchyk A, Li M, Andersen SL, Arbeev K, Yashin A, Zmuda J, An P, Feitosa M, Giuliani C, Franceschi C, Garagnani P, Mengel-From J, Atzmon G, Barzilai N, Puca A, Schork NJ, Perls TT, Sebastiani P. A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants. Int J Mol Sci. 2022 Dec 21; 24(1).View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 36613555; PMCID: PMC9820206; DOI: 10.3390/ijms24010116;

Gurinovich A, Li M, Leshchyk A, Bae H, Song Z, Arbeev KG, Nygaard M, Feitosa MF, Perls TT, Sebastiani P. Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data. Front Genet. 2022; 13:897210.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 36212134; PMCID: PMC9544087; DOI: 10.3389/fgene.2022.897210;

Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patti GJ, Perls TT. A metabolomic signature of the APOE2 allele. Geroscience. 2023 Feb; 45(1):415-426.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 35997888; PMCID: PMC9886693; DOI: 10.1007/s11357-022-00646-9;

Barral S, Andersen SL, Perls TT, Bae H, Sebastiani P, Christensen K, Thyagarajan B, Lee J, Schupf N. Association between late maternal age and age-related endophenotypes in the Long Life Family Study. Neurosci Lett. 2022 Jul 27; 784:136737.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 35709880; PMCID: PMC11061875; DOI: 10.1016/j.neulet.2022.136737;

Wojczynski MK, Jiuan Lin S, Sebastiani P, Perls TT, Lee J, Kulminski A, Newman A, Zmuda JM, Christensen K, Province MA. NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes. J Gerontol A Biol Sci Med Sci. 2022 Apr 01; 77(4):717-727.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 34739053; PMCID: PMC8974329; DOI: 10.1093/gerona/glab333;

Du M, Andersen SL, Cosentino S, Boudreau RM, Perls TT, Sebastiani P. Digitally generated Trail Making Test data: Analysis using hidden Markov modeling. Alzheimers Dement (Amst). 2022; 14(1):e12292.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 35280964; PMCID: PMC8902814; DOI: 10.1002/dad2.12292;

Gunn S, Wainberg M, Song Z, Andersen S, Boudreau R, Feitosa MF, Tan Q, Montasser ME, O'Connell JR, Stitziel N, Price N, Perls T, Schork NJ, Sebastiani P. Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring. Geroscience. 2022 Apr; 44(2):719-729.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 35119614; PMCID: PMC9135909; DOI: 10.1007/s11357-022-00518-2;

Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Correction to: Effect of longevity genetic variants on the molecular aging rate. Geroscience. 2021 Aug; 43(4):2101.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 34143375; PMCID: PMC8492867; DOI: 10.1007/s11357-021-00400-7;

Renner SW, Qiao Y, Gmelin T, Santanasto AJ, Boudreau RM, Walston JD, Perls TT, Christensen K, Newman AB, Glynn NW. Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study. Aging Clin Exp Res. 2022 Feb; 34(2):367-374. PMID: 34196949; PMCID: PMC8864668; DOI: 10.1007/s40520-021-01923-x;

Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Effect of longevity genetic variants on the molecular aging rate. Geroscience. 2021 06; 43(3):1237-1251.View Related Profiles.

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Andersen, Stacy
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Perls, Thomas

PMID: 33948810; PMCID: PMC8190315; DOI: 10.1007/s11357-021-00376-4;

Andersen SL, Du M, Cosentino S, Schupf N, Rosso AL, Perls TT, Sebastiani P. Slower Decline in Processing Speed Is Associated with Familial Longevity. Gerontology. 2022; 68(1):17-29.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 33946077; PMCID: PMC9093735; DOI: 10.1159/000514950;

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2021 Apr 23; 12(1):2463.View Related Profiles.

Murabito, Joanne
Lunetta, Kathryn
Sebastiani, Paola
Perls, Thomas

PMID: 33893282; PMCID: PMC8065049; DOI: 10.1038/s41467-021-22613-2;

Feitosa MF, Kuipers AL, Wojczynski MK, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA. Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments. Circ Genom Precis Med. 2021 06; 14(3):e003201. PMID: 33844929; PMCID: PMC8214825; DOI: 10.1161/CIRCGEN.120.003201;

Sebastiani P, Federico A, Morris M, Gurinovich A, Tanaka T, Chandler KB, Andersen SL, Denis G, Costello CE, Ferrucci L, Jennings L, Glass DJ, Monti S, Perls TT. Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. Aging Cell. 2021 02; 20(2):e13290.View Related Profiles.

Costello, Catherine
Denis, Gerald
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 33512769; PMCID: PMC7884029; DOI: 10.1111/acel.13290;

Xiang Q, Andersen SL, Perls TT, Sebastiani P. Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression. Front Genet. 2020; 11:606831.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 33488674; PMCID: PMC7820893; DOI: 10.3389/fgene.2020.606831;

Perls TT. Cognitive Trajectories and Resilience in Centenarians-Findings From the 100-Plus Study. JAMA Netw Open. 2021 01 04; 4(1):e2032538. PMID: 33449091

Sweigart B, Andersen SL, Gurinovich A, Cosentino S, Schupf N, Perls TT, Sebastiani P. APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age. J Alzheimers Dis. 2021; 83(2):853-860.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 34366332; PMCID: PMC8896199; DOI: 10.3233/JAD-201205;

Andersen SL, Sweigart B, Glynn NW, Wojczynski MK, Thyagarajan B, Mengel-From J, Thielke S, Perls TT, Libon DJ, Au R, Cosentino S, Sebastiani P. Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior. J Alzheimers Dis. 2021; 82(1):17-32.View Related Profiles.

Sebastiani, Paola
Au, Rhoda
Andersen, Stacy
Perls, Thomas

PMID: 34219735; PMCID: PMC8328075; DOI: 10.3233/JAD-201119;

Du M, Andersen SL, Schupf N, Feitosa MF, Barker MS, Perls TT, Sebastiani P. Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study. J Alzheimers Dis. 2021; 79(1):117-125.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 33216038; PMCID: PMC7952213; DOI: 10.3233/JAD-201113;

Lau-Ng R, Caruso LB, Perls TT. Reply to Comment on COVID-19 Deaths in Long Term Care Facilities - A Critical Piece of the Puzzle. J Am Geriatr Soc. 2020 12; 68(12):2748.View Related Profiles.

Caruso, Lisa
Lau-Ng, Rossana
Perls, Thomas

PMID: 32835433

Lau-Ng R, Caruso LB, Perls TT. COVID-19 Deaths in Long-Term Care Facilities: A Critical Piece of the Pandemic Puzzle. J Am Geriatr Soc. 2020 09; 68(9):1895-1898.View Related Profiles.

Caruso, Lisa
Lau-Ng, Rossana
Perls, Thomas

PMID: 32501537; PMCID: PMC7300761; DOI: 10.1111/jgs.16669;

Sebastiani P, Andersen SL, Sweigart B, Du M, Cosentino S, Thyagarajan B, Christensen K, Schupf N, Perls TT. Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. Geroscience. 2020 10; 42(5):1335-1350.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 32514870; PMCID: PMC7525612; DOI: 10.1007/s11357-020-00202-3;

de Las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, Chasman DI, Aschard H, Bartz TM, Bielak LF, Campbell A, Cheng CY, Dorajoo R, Hartwig FP, Horimoto ARVR, Li C, Li-Gao R, Liu Y, Marten J, Musani SK, Ntalla I, Rankinen T, Richard M, Sim X, Smith AV, Tajuddin SM, Tayo BO, Vojinovic D, Warren HR, Xuan D, Alver M, Boissel M, Chai JF, Chen X, Christensen K, Divers J, Evangelou E, Gao C, Girotto G, Harris SE, He M, Hsu FC, Kühnel B, Laguzzi F, Li X, Lyytikäinen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Rueedi R, Shu XO, Snieder H, Sofer T, Takeuchi F, Verweij N, Ware EB, Weiss S, Yanek LR, Amin N, Arking DE, Arnett DK, Bergmann S, Boerwinkle E, Brody JA, Broeckel U, Brumat M, Burke G, Cabrera CP, Canouil M, Chee ML, Chen YI, Cocca M, Connell J, de Silva HJ, de Vries PS, Eiriksdottir G, Faul JD, Fisher V, Forrester T, Fox EF, Friedlander Y, Gao H, Gigante B, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt S, Ikram MA, Irvin MR, Kähönen M, Kavousi M, Khor CC, Kilpeläinen TO, Koh WP, Komulainen P, Kraja AT, Krieger JE, Langefeld CD, Li Y, Liang J, Liewald DCM, Liu CT, Liu J, Lohman KK, Mägi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Nalls MA, Nelson CP, Norris JM, O'Connell J, Ogunniyi A, Padmanabhan S, Palmer ND, Pedersen NL, Perls T, Peters A, Petersmann A, Peyser PA, Polasek O, Porteous DJ, Raffel LJ, Rice TK, Rotter JI, Rudan I, Rueda-Ochoa OL, Sabanayagam C, Salako BL, Schreiner PJ, Shikany JM, Sidney SS, Sims M, Sitlani CM, Smith JA, Starr JM, Strauch K, Swertz MA, Teumer A, Tham YC, Uitterlinden AG, Vaidya D, van der Ende MY, Waldenberger M, Wang L, Wang YX, Wei WB, Weir DR, Wen W, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Bowden DW, Deary IJ, Dörr M, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kammerer CM, Kato N, Lakka TA, Leander K, Lehtimäki T, Magnusson PKE, Marques-Vidal P, Penninx BWJH, Samani NJ, van der Harst P, Wagenknecht LE, Wu T, Zheng W, Zhu X, Bouchard C, Cooper RS, Correa A, Evans MK, Gudnason V, Hayward C, Horta BL, Kelly TN, Kritchevsky SB, Levy D, Palmas WR, Pereira AC, Province MM, Psaty BM, Ridker PM, Rotimi CN, Tai ES, van Dam RM, van Duijn CM, Wong TY, Rice K, Gauderman WJ, Morrison AC, North KE, Kardia SLR, Caulfield MJ, Elliott P, Munroe PB, Franks PW, Rao DC, Fornage M. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry. 2021 06; 26(6):2111-2125.View Related Profiles.

Liu, Ching-Ti
Perls, Thomas

PMID: 32372009; PMCID: PMC7641978; DOI: 10.1038/s41380-020-0719-3;

Feitosa MF, Lunetta KL, Wang L, Wojczynski MK, Kammerer CM, Perls T, Schupf N, Christensen K, Murabito JM, Province MA. Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. Atherosclerosis. 2020 03; 297:102-110.View Related Profiles.

Murabito, Joanne
Lunetta, Kathryn
Perls, Thomas

PMID: 32109663; PMCID: PMC8098811; DOI: 10.1016/j.atherosclerosis.2020.02.005;

Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls TT, Andersen SL. Purpose in Life Among Centenarian Offspring. J Gerontol B Psychol Sci Soc Sci. 2020 01 14; 75(2):308-315.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 29522128; PMCID: PMC7179803; DOI: 10.1093/geronb/gby023;

Perls TT, Tan EJ. Healthy Longevity: An Introduction to the Special Issue. J Gerontol A Biol Sci Med Sci. 2019 11 13; 74(Suppl_1):S1-S3. PMID: 31724053

Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Krämer BK, Kronenberg F, Kubo M, Kühnel B, La Bianca M, Lange LA, Lehne B, Lehtimäki T, Liu J, Loeffler M, Loos RJF, Lyytikäinen LP, Magi R, Mahajan A, Martin NG, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y, O'Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Müller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell JR, Olafsson I, Padmanabhan S, Penninx BWJH, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tönjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Völker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Böger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Köttgen A. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nat Genet. 2019 10; 51(10):1459-1474.View Related Profiles.

O'Donnell, Christopher
Gaziano, J. Michael
Yang, Qiong
Hwang, Shih-Jen
Perls, Thomas

PMID: 31578528; PMCID: PMC6858555; DOI: 10.1038/s41588-019-0504-x;

Bae H, Lunetta KL, Murabito JM, Andersen SL, Schupf N, Perls T, Sebastiani P. Genetic associations with age of menopause in familial longevity. Menopause. 2019 10; 26(10):1204-1212.View Related Profiles.

Murabito, Joanne
Lunetta, Kathryn
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 31188284; PMCID: PMC7008937; DOI: 10.1097/GME.0000000000001367;

Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P. PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects. Bioinformatics. 2019 09 01; 35(17):3046-3054.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 30624692; PMCID: PMC6735784; DOI: 10.1093/bioinformatics/btz017;

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 08 14; 10(1):3669.View Related Profiles.

Sarnowski, Chloe
Murabito, Joanne
Lunetta, Kathryn
Sebastiani, Paola
Perls, Thomas

PMID: 31413261; PMCID: PMC6694136; DOI: 10.1038/s41467-019-11558-2;

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT. A serum protein signature of APOE genotypes in centenarians. Aging Cell. 2019 12; 18(6):e13023.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 31385390; PMCID: PMC6826130; DOI: 10.1111/acel.13023;

Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpeläinen TO, Richard MA, Aslibekyan S, Bartz TM, Dorajoo R, Li C, Liu Y, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, He M, Horimoto ARVR, Hsu FC, Jackson AU, Kammerer CM, Kasturiratne A, Komulainen P, Kühnel B, Leander K, Lee WJ, Lin KH, Luan J, Lyytikäinen LP, McKenzie CA, Nelson CP, Noordam R, Scott RA, Sheu WHH, Stancáková A, Takeuchi F, van der Most PJ, Varga TV, Waken RJ, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking DE, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cade B, Campbell A, Canouil M, Chakravarti A, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Gu CC, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hofman A, Howard BV, Hunt SC, Irvin MR, Jia Y, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Kooperberg CB, Krieger JE, Kubo M, Kutalik Z, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lee JH, Lehne B, Levy D, Lewis CE, Li Y, Lim SH, Liu CT, Liu J, Liu J, Liu Y, Loh M, Lohman KK, Louie T, Mägi R, Matsuda K, Meitinger T, Metspalu A, Milani L, Momozawa Y, Mosley TH, Nalls MA, Nasri U, O'Connell JR, Ogunniyi A, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Porteous D, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Sever P, Sims M, Sitlani CM, Smith BH, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Wilson G, Wojczynski MK, Xiang YB, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, Weir DR, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Oldehinkel AJ, Pereira AC, Perls T, Rauramaa R, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Wickremasinghe AR, Wu T, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Hixson J, Kardia SLR, Kritchevsky SB, Psaty BM, van Dam RM, Arnett DK, Mook-Kanamori DO, Fornage M, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotimi CN, Bierut LJ, Zhu X, Cupples LA, Province MA, Rotter JI, Franks PW, Rice K, Elliott P, Caulfield MJ, Gauderman WJ, Munroe PB, Rao DC, Morrison AC. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 08 01; 28(15):2615-2633.View Related Profiles.

Liu, Ching-Ti
Cupples, L
Perls, Thomas

PMID: 31127295; PMCID: PMC6644157; DOI: 10.1093/hmg/ddz070;

Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB. Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism. Geroscience. 2019 08; 41(4):383-393.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 31332674; PMCID: PMC6815318; DOI: 10.1007/s11357-019-00086-y;

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet. 2019 06; 51(6):957-972.View Related Profiles.

Gaziano, J. Michael
Yang, Qiong
Hwang, Shih-Jen
Perls, Thomas

PMID: 31152163; PMCID: PMC6698888; DOI: 10.1038/s41588-019-0407-x;

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. J Gerontol A Biol Sci Med Sci. 2019 01 01; 74(1):44-51.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 30060062; PMCID: PMC6298189; DOI: 10.1093/gerona/gly174;

Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT. Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring. J Gerontol A Biol Sci Med Sci. 2019 01 01; 74(1):108-113.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 29931286; PMCID: PMC6298187; DOI: 10.1093/gerona/gly141;

Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 01 03; 104(1):112-138.View Related Profiles.

Liu, Chunyu
Fetterman, Jessica
Argos, Maria
Perls, Thomas

PMID: 30595373; PMCID: PMC6323610; DOI: 10.1016/j.ajhg.2018.12.001;

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1472-1481. PMID: 30299504; PMCID: PMC6175028; DOI: 10.1093/gerona/gly057;

Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1439-1447.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 28977569; PMCID: PMC6175020; DOI: 10.1093/gerona/glx124;

Nebbia G, Nussbaum L, Helmkamp A, Andersen S, Perls T, Sebastiani P. Manual and Automated Procedures for Compiling a Very Large Sample of Centenarian Pedigrees. N Am Actuar J. 2018; 22(4):591-599.View Related Profiles.

Helmkamp, Annie
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 31435182; PMCID: PMC6703835; DOI: 10.1080/10920277.2018.1462716;

Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL, Yang H, Vaupel J. Sex Differences in Genetic Associations With Longevity. JAMA Netw Open. 2018 Aug; 1(4).View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 30294719; PMCID: PMC6173523; DOI: 10.1001/jamanetworkopen.2018.1670;

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R, Fisher V, Hartwig FP, Horimoto ARVR, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Wojczynski MK, Alver M, Boissel M, Cai Q, Campbell A, Chai JF, Chen X, Divers J, Gao C, Goel A, Hagemeijer Y, Harris SE, He M, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Komulainen P, Kühnel B, Laguzzi F, Luan J, Matoba N, Nolte IM, Padmanabhan S, Riaz M, Rueedi R, Robino A, Said MA, Scott RA, Sofer T, Stancáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Vitart V, Wang Y, Ware EB, Warren HR, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Boerwinkle E, Borecki I, Broeckel U, Brown M, Brumat M, Burke GL, Canouil M, Chakravarti A, Charumathi S, Ida Chen YD, Connell JM, Correa A, de Las Fuentes L, de Mutsert R, de Silva HJ, Deng X, Ding J, Duan Q, Eaton CB, Ehret G, Eppinga RN, Evangelou E, Faul JD, Felix SB, Forouhi NG, Forrester T, Franco OH, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gigante B, Gu CC, Gu D, Hagenaars SP, Hallmans G, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Howard BV, Ikram MA, John U, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Lin S, Liu J, Liu J, Loh M, Louie T, Mägi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Nalls MA, Nelson CP, Sotoodehnia N, Norris JM, O'Connell JR, Palmer ND, Perls T, Pedersen NL, Peters A, Peyser PA, Poulter N, Raffel LJ, Raitakari OT, Roll K, Rose LM, Rosendaal FR, Rotter JI, Schmidt CO, Schreiner PJ, Schupf N, Scott WR, Sever PS, Shi Y, Sidney S, Sims M, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Turner ST, Uitterlinden AG, Vollenweider P, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Yao J, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kamatani Y, Kato N, Kooner JS, Kutalik Z, Laakso M, Laurie CC, Leander K, Lehtimäki T, Study LC, Magnusson PKE, Oldehinkel AJ, Penninx BWJH, Polasek O, Porteous DJ, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Bouchard C, Christensen K, Evans MK, Gudnason V, Horta BL, Kardia SLR, Liu Y, Pereira AC, Psaty BM, Ridker PM, van Dam RM, Gauderman WJ, Zhu X, Mook-Kanamori DO, Fornage M, Rotimi CN, Cupples LA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Kooperberg C, Palmas W, Rice K, Morrison AC, Elliott P, Caulfield MJ, Munroe PB, Rao DC, Province MA, Levy D. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018; 13(6):e0198166.View Related Profiles.

Cupples, L
Perls, Thomas

PMID: 29912962; PMCID: PMC6005576; DOI: 10.1371/journal.pone.0198166;

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB. A novel healthy blood pressure phenotype in the Long Life Family Study. J Hypertens. 2018 01; 36(1):43-53.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 28837423; PMCID: PMC5893936; DOI: 10.1097/HJH.0000000000001514;

Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. Assortative Mating by Ethnicity in Longevous Families. Front Genet. 2017; 8:186.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 29209360; PMCID: PMC5702482; DOI: 10.3389/fgene.2017.00186;

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. J Gerontol A Biol Sci Med Sci. 2017 Oct 12; 72(11):1453-1464.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 28329165; PMCID: PMC5861867; DOI: 10.1093/gerona/glx027;

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, McDaid AF, Porteous D, Winkler TW, Salvi E, Shrine N, Liu X, Ang WQ, Zhang W, Feitosa MF, Venturini C, van der Most PJ, Rosengren A, Wood AR, Beaumont RN, Jones SE, Ruth KS, Yaghootkar H, Tyrrell J, Havulinna AS, Boers H, Mägi R, Kriebel J, Müller-Nurasyid M, Perola M, Nieminen M, Lokki ML, Kähönen M, Viikari JS, Geller F, Lahti J, Palotie A, Koponen P, Lundqvist A, Rissanen H, Bottinger EP, Afaq S, Wojczynski MK, Lenzini P, Nolte IM, Sparsø T, Schupf N, Christensen K, Perls TT, Newman AB, Werge T, Snieder H, Spector TD, Chambers JC, Koskinen S, Melbye M, Raitakari OT, Lehtimäki T, Tobin MD, Wain LV, Sinisalo J, Peters A, Meitinger T, Martin NG, Wray NR, Montgomery GW, Medland SE, Swertz MA, Vartiainen E, Borodulin K, Männistö S, Murray A, Bochud M, Jacquemont S, Rivadeneira F, Hansen TF, Oldehinkel AJ, Mangino M, Province MA, Deloukas P, Kooner JS, Freathy RM, Pennell C, Feenstra B, Strachan DP, Lettre G, Hirschhorn J, Cusi D, Heid IM, Hayward C, Männik K, Beckmann JS, Loos RJF, Nyholt DR, Metspalu A, Eriksson JG, Weedon MN, Salomaa V, Franke L, Reymond A, Frayling TM, Kutalik Z. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun. 2017 09 29; 8(1):744. PMID: 28963451; PMCID: PMC5622064; DOI: 10.1038/s41467-017-00556-x;

Perls TT. Male Centenarians: How and Why Are They Different from Their Female Counterparts? J Am Geriatr Soc. 2017 09; 65(9):1904-1906. PMID: 28586117; PMCID: PMC5603374; DOI: 10.1111/jgs.14978;

Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N. Telomere length is longer in women with late maternal age. Menopause. 2017 May; 24(5):497-501.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 27922939; PMCID: PMC5403597; DOI: 10.1097/GME.0000000000000795;

Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT. Limitations and risks of meta-analyses of longevity studies. Mech Ageing Dev. 2017 Jul; 165(Pt B):139-146.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 28143747; PMCID: PMC5533653; DOI: 10.1016/j.mad.2017.01.008;

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell. 2017 Apr; 16(2):329-338.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Perls, Thomas

PMID: 28058805; PMCID: PMC5334528; DOI: 10.1111/acel.12557;

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study. J Am Geriatr Soc. 2016 Nov; 64(11):e189-e194.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Perls, Thomas

PMID: 27783390; PMCID: PMC5118076; DOI: 10.1111/jgs.14522;

Pedersen JK, Elo IT, Schupf N, Perls TT, Stallard E, Yashin AI, Christensen K. The Survival of Spouses Marrying Into Longevity-Enriched Families. J Gerontol A Biol Sci Med Sci. 2017 Jan; 72(1):109-114. PMID: 27540092; PMCID: PMC5155661; DOI: 10.1093/gerona/glw159;

Sebastiani P, Perls TT. Detection of Significant Groups in Hierarchical Clustering by Resampling. Front Genet. 2016; 7:144.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 27551289; PMCID: PMC4976109; DOI: 10.3389/fgene.2016.00144;

Perls TT. Testosterone Treatment in Older Men. N Engl J Med. 2016 Jul 7; 375(1):88. PMID: 27406355; DOI: 10.1056/NEJMc1603665#SA1;

Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, Barzilai N, Milman S. Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity. J Am Geriatr Soc. 2016 Aug; 64(8):1583-91.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 27377170; PMCID: PMC4988893; DOI: 10.1111/jgs.14222;

Sanders JL, Singh J, Minster RL, Walston JD, Matteini AM, Christensen K, Mayeux R, Borecki IB, Perls T, Newman AB. Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology. J Am Geriatr Soc. 2016 Aug; 64(8):1679-83. PMID: 27294813; PMCID: PMC4988884; DOI: 10.1111/jgs.14190;

Bae H, Monti S, Montano M, Steinberg MH, Perls TT, Sebastiani P. Learning Bayesian Networks from Correlated Data. Sci Rep. 2016 05 05; 6:25156.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola
Monti, Stefano
Perls, Thomas

PMID: 27146517; PMCID: PMC4857179; DOI: 10.1038/srep25156;

Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Viña J, Perls T, Sachdev PS. ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol. 2016 Apr 21; 16:52.View Related Profiles.

Andersen, Stacy
Perls, Thomas

PMID: 27098177; PMCID: PMC4839126; DOI: 10.1186/s12883-016-0569-4;

Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Novel loci and pathways significantly associated with longevity. Sci Rep. 2016 Feb 25; 6:21243.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 26912274; PMCID: PMC4766491; DOI: 10.1038/srep21243;

Perls T. Brocklehurst’s Textbook of Geriatric Medicine and Gerontology (Rockwood K, Fillit H, Young J, Eds.). Centenarians. Elsevir. New York City. 2016.

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Familial Risk for Exceptional Longevity. N Am Actuar J. 2016 Jan 01; 20(1):57-64.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 27041978; PMCID: PMC4812435; DOI: 10.1080/10920277.2015.1061946;

Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ. Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):435-44. PMID: 26419976; PMCID: PMC5014189; DOI: 10.1093/gerona/glv164;

Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, Province MA, Sanders JL, Perls T, Christensen K, Lee JH, Mayeux R, Schupf N. Heritability of telomere length in a study of long-lived families. Neurobiol Aging. 2015 Oct; 36(10):2785-90. PMID: 26239175; PMCID: PMC4562863; DOI: 10.1016/j.neurobiolaging.2015.06.017;

Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciag A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Calì G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA. Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis. Circ Res. 2015 Jul 31; 117(4):333-45. PMID: 26034043; PMCID: PMC5496930; DOI: 10.1161/CIRCRESAHA.117.305875;

Sebastiani P, Nussbaum L, Andersen SL, Black MJ, Perls TT. Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity". J Gerontol A Biol Sci Med Sci. 2016 Mar; 71(3):340-6.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 25814633; PMCID: PMC4757962; DOI: 10.1093/gerona/glv020;

Perls T, Handelsman DJ. Disease mongering of age-associated declines in testosterone and growth hormone levels. J Am Geriatr Soc. 2015 Apr; 63(4):809-11. PMID: 25809947; DOI: 10.1111/jgs.13391;

Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. J Gerontol A Biol Sci Med Sci. 2015 Aug; 70(8):1003-8.View Related Profiles.

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PMID: 25758594; PMCID: PMC4506316; DOI: 10.1093/gerona/glv006;

Ash AS, Kroll-Desrosiers AR, Hoaglin DC, Christensen K, Fang H, Perls TT. Are Members of Long-Lived Families Healthier Than Their Equally Long-Lived Peers? Evidence From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2015 Aug; 70(8):971-6. PMID: 25745037; PMCID: PMC4506317; DOI: 10.1093/gerona/glv015;

Bae H, Perls T, Steinberg M, Sebastiani P. Bayesian Polynomial Regression Models to Fit Multiple Genetic Models for Quantitative Traits. Bayesian Anal. 2015 Mar; 10(1):53-74.View Related Profiles.

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PMID: 26029316; PMCID: PMC4446790; DOI: 10.1214/14-BA880;

Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the Long Life Family Study. Aging (Albany NY). 2015 Feb; 7(2):123-32.View Related Profiles.

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PMID: 25664523; PMCID: PMC4359694; DOI: 10.18632/aging.100724;

Sun F, Sebastiani P, Schupf N, Bae H, Andersen SL, McIntosh A, Abel H, Elo IT, Perls TT. Extended maternal age at birth of last child and women's longevity in the Long Life Family Study. Menopause. 2015 Jan; 22(1):26-31.View Related Profiles.

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PMID: 24977462; PMCID: PMC4270889; DOI: 10.1097/GME.0000000000000276;

Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R. Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly. JAMA Neurol. 2014 Dec; 71(12):1514-9. PMID: 25317765; PMCID: PMC4355405; DOI: 10.1001/jamaneurol.2014.1663;

Bae HT, Perls TT, Sebastiani P. An efficient technique for Bayesian modeling of family data using the BUGS software. Front Genet. 2014; 5:390.View Related Profiles.

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PMID: 25477899; PMCID: PMC4235415; DOI: 10.3389/fgene.2014.00390;

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SL, Kiel DP, Oostra BA, Orwoll ES, Parimi N, Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015 Jan; 70(1):110-8.View Related Profiles.

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PMID: 25199915; PMCID: PMC4296168; DOI: 10.1093/gerona/glu166;

Kaufman LB, Setiono TK, Doros G, Andersen S, Silliman RA, Friedman PK, Perls TT. An oral health study of centenarians and children of centenarians. J Am Geriatr Soc. 2014 Jun; 62(6):1168-73.View Related Profiles.

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PMID: 24889721; PMCID: PMC4057979; DOI: 10.1111/jgs.12842;

Lee JH, Cheng R, Honig LS, Feitosa M, Kammerer CM, Kang MS, Schupf N, Lin SJ, Sanders JL, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet. 2013; 4:310. PMID: 24478790; PMCID: PMC3894567; DOI: 10.3389/fgene.2013.00310;

An P, Miljkovic I, Thyagarajan B, Kraja AT, Daw EW, Pankow JS, Selvin E, Kao WH, Maruthur NM, Nalls MA, Liu Y, Harris TB, Lee JH, Borecki IB, Christensen K, Eckfeldt JH, Mayeux R, Perls TT, Newman AB, Province MA. Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). Metabolism. 2014 Apr; 63(4):461-8. PMID: 24405752; PMCID: PMC3965585; DOI: 10.1016/j.metabol.2013.11.018;

Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013; 1:38.View Related Profiles.

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PMID: 24350207; PMCID: PMC3859985; DOI: 10.3389/fpubh.2013.00038;

Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY). 2013 Sep; 5(9):653-61.View Related Profiles.

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PMID: 24244950; PMCID: PMC3808698; DOI: 10.18632/aging.100594;

Sanders JL, Minster RL, Barmada MM, Matteini AM, Boudreau RM, Christensen K, Mayeux R, Borecki IB, Zhang Q, Perls T, Newman AB. Heritability of and mortality prediction with a longevity phenotype: the healthy aging index. J Gerontol A Biol Sci Med Sci. 2014 Apr; 69(4):479-85. PMID: 23913930; PMCID: PMC3968826; DOI: 10.1093/gerona/glt117;

Barral S, Cosentino S, Costa R, Andersen SL, Christensen K, Eckfeldt JH, Newman AB, Perls TT, Province MA, Hadley EC, Rossi WK, Mayeux R. Exceptional memory performance in the Long Life Family Study. Neurobiol Aging. 2013 Nov; 34(11):2445-8.View Related Profiles.

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PMID: 23759147; PMCID: PMC4095822; DOI: 10.1016/j.neurobiolaging.2013.05.002;

Perls T. The reappearance of procaine hydrochloride (Gerovital H3) for antiaging. J Am Geriatr Soc. 2013 Jun; 61(6):1024-5. PMID: 23772727; DOI: 10.1111/jgs.12278;

Elo IT, Mykyta L, Sebastiani P, Christensen K, Glynn NW, Perls T. Age validation in the long life family study through a linkage to early-life census records. J Gerontol B Psychol Sci Soc Sci. 2013 Jul; 68(4):580-5.View Related Profiles.

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PMID: 23704206; PMCID: PMC3674734; DOI: 10.1093/geronb/gbt033;

Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT. Genome-wide association study of personality traits in the long life family study. Front Genet. 2013; 4:65.View Related Profiles.

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PMID: 23658558; PMCID: PMC3647245; DOI: 10.3389/fgene.2013.00065;

Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT. Personality factors in the Long Life Family Study. J Gerontol B Psychol Sci Soc Sci. 2013 Sep; 68(5):739-49.View Related Profiles.

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PMID: 23275497; PMCID: PMC3744045; DOI: 10.1093/geronb/gbs117;

Sebastiani P, Perls TT. The genetics of extreme longevity: lessons from the new England centenarian study. Front Genet. 2012; 3:277.View Related Profiles.

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PMID: 23226160; PMCID: PMC3510428; DOI: 10.3389/fgene.2012.00277;

Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi WK, Mayeux R. Apolipoprotein E and familial longevity. Neurobiol Aging. 2013 Apr; 34(4):1287-91. PMID: 23040522; PMCID: PMC3545094; DOI: 10.1016/j.neurobiolaging.2012.08.019;

Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell. 2012 Jun; 11(3):475-81.View Related Profiles.

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PMID: 22340368; PMCID: PMC3350595; DOI: 10.1111/j.1474-9726.2012.00808.x;

Michael Anson R, Willcox B, Austad S, Perls T. Within- and between-species study of extreme longevity--comments, commonalities, and goals. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):347-50. PMID: 22419221; PMCID: PMC3309878; DOI: 10.1093/gerona/gls010;

Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012; 7(1):e29848.View Related Profiles.

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PMID: 22279548; PMCID: PMC3261167; DOI: 10.1371/journal.pone.0029848;

Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):395-405.View Related Profiles.

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PMID: 22219514; PMCID: PMC3309876; DOI: 10.1093/gerona/glr223;

Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls TT. Whole genome sequences of a male and female supercentenarian, ages greater than 114?years. Front Genet. 2011; 2:90.View Related Profiles.

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PMID: 22303384; PMCID: PMC3262222; DOI: 10.3389/fgene.2011.00090;

Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Retraction. Science. 2011 Jul 22; 333(6041):404.View Related Profiles.

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PMID: 21778381; DOI: 10.1126/science.333.6041.404-a;

Kulminski AM, Arbeev KG, Christensen K, Mayeux R, Newman AB, Province MA, Hadley EC, Rossi W, Perls TT, Elo IT, Yashin AI. Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits. Mech Ageing Dev. 2011 Apr; 132(4):195-201. PMID: 21463647; PMCID: PMC3139988; DOI: 10.1016/j.mad.2011.03.006;

Young RD, Desjardins B, McLaughlin K, Poulain M, Perls TT. Typologies of extreme longevity myths. Curr Gerontol Geriatr Res. 2010; 2010:423087. PMID: 21461047; PMCID: PMC3062986; DOI: 10.1155/2010/423087;

Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY). 2011 Jan; 3(1):63-76.View Related Profiles.

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Perls, Thomas

PMID: 21258136; PMCID: PMC3047140; DOI: 10.18632/aging.100242;

Solovieff N, Hartley SW, Baldwin CT, Perls TT, Steinberg MH, Sebastiani P. Clustering by genetic ancestry using genome-wide SNP data. BMC Genet. 2010; 11:108.View Related Profiles.

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PMID: 21143920; PMCID: PMC3018397; DOI: 10.1186/1471-2156-11-108;

Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Genetic signatures of exceptional longevity in humans. Science. 2010 Jul 1; 2010.View Related Profiles.

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PMID: 20595579; DOI: 10.1126/science.1190532;

Sebastiani P, Perls TT. Prediction models that include genetic data. Circ Cardiovasc Genet. 2010 Feb; 3(1):1-2.View Related Profiles.

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PMID: 20160188; PMCID: PMC2895327; DOI: 10.1161/CIRCGENETICS.110.937862;

Perls T. Health and disease in people over 85. BMJ. 2009; 339:b4715. PMID: 20028776; DOI: 10.1136/bmj.b4715;

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009; 4(12):e8210.View Related Profiles.

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PMID: 20011587; PMCID: PMC2788130; DOI: 10.1371/journal.pone.0008210;

Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS. A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol. 2009 Dec 15; 170(12):1555-62.View Related Profiles.

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PMID: 19910380; PMCID: PMC2800272; DOI: 10.1093/aje/kwp309;

Perls TT. Growth hormone and anabolic steroids: athletes are the tip of the iceberg. Drug Test Anal. 2009 Sep; 1(9-10):419-25. PMID: 20355224; DOI: 10.1002/dta.87;

Sebastiani P, Timofeev N, Dworkis DA, Perls TT, Steinberg MH. Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol. 2009 Aug; 84(8):504-15.View Related Profiles.

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PMID: 19569043; PMCID: PMC2895326; DOI: 10.1002/ajh.21440;

Givens JL, Frederick M, Silverman L, Anderson S, Senville J, Silver M, Sebastiani P, Terry DF, Costa PT, Perls TT. Personality traits of centenarians' offspring. J Am Geriatr Soc. 2009 Apr; 57(4):683-5.View Related Profiles.

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PMID: 19392961; PMCID: PMC2895990; DOI: 10.1111/j.1532-5415.2009.02189.x;

Zhao Z, Timofeev N, Hartley SW, Chui DH, Fucharoen S, Perls TT, Steinberg MH, Baldwin CT, Sebastiani P. Imputation of missing genotypes: an empirical evaluation of IMPUTE. BMC Genet. 2008; 9:85.View Related Profiles.

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PMID: 19077279; PMCID: PMC2636842; DOI: 10.1186/1471-2156-9-85;

Adams ER, Nolan VG, Andersen SL, Perls TT, Terry DF. Centenarian offspring: start healthier and stay healthier. J Am Geriatr Soc. 2008 Nov; 56(11):2089-92.View Related Profiles.

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PMID: 18811609; PMCID: PMC2892731; DOI: 10.1111/j.1532-5415.2008.01949.x;

Terry DF, Nolan VG, Andersen SL, Perls TT, Cawthon R. Association of longer telomeres with better health in centenarians. J Gerontol A Biol Sci Med Sci. 2008 Aug; 63(8):809-12.View Related Profiles.

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PMID: 18772468; PMCID: PMC2892727; DOI: 10.1093/gerona/63.8.809;

Olshansky SJ, Perls TT. New developments in the illegal provision of growth hormone for "anti-aging" and bodybuilding. JAMA. 2008 Jun 18; 299(23):2792-4. PMID: 18560007; DOI: 10.1001/jama.299.23.2792;

Terry DF, Sebastiani P, Andersen SL, Perls TT. Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med. 2008 Feb 11; 168(3):277-83.View Related Profiles.

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PMID: 18268168; PMCID: PMC2895331; DOI: 10.1001/archinternmed.2007.75;

Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, Sedgewick AE, Doria A, Montano M, Melista E, Terry D, Perls TT, Steinberg MH, Baldwin CT. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genet. 2008; 9:6.View Related Profiles.

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PMID: 18194558; PMCID: PMC2248205; DOI: 10.1186/1471-2156-9-6;

Perls T. Aging, Biotechnology, and the Future (Read CY, Green RC, Smyer MA, Eds.). Centenarians and genetics. Johns Hopkins University Press. 2008.
Sebastiani P, Perls T. Bayesian Belief Networks: A Practical Guide to Applications (Pourret O, Naim P, Marcot BG, Eds.). Complex Genetic Models. Wiley. New York. 2008.

Perls T, Kohler IV, Andersen S, Schoenhofen E, Pennington J, Young R, Terry D, Elo IT. Survival of parents and siblings of supercentenarians. J Gerontol A Biol Sci Med Sci. 2007 Sep; 62(9):1028-34.View Related Profiles.

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PMID: 17895443; PMCID: PMC3258444; DOI: 10.1093/gerona/62.9.1028;

Perls TT. DHEA and testosterone in the elderly. N Engl J Med. 2007 Feb 8; 356(6):636; author reply 637. PMID: 17288051

Poon LW, Perls TT. Annual Review of Gerontology And Geriatrics: Biopsychosocial Approaches to Longevity (Poon L, Perls T, Eds.). The trials and tribulations of studying the oldest old. Springer. 2007.
Perls TT. Annual Review of Gerontology and Geriatrics: Biopsychosocial Approaches to Longevity (Poon L, Perls T, Eds.). The familiality of exceptional longevity. Springer. 2007.
Perls T, Sebastiani P. Molecular Biology of Aging (Guarente LP, Partridge L, Wallace DC, Eds.). Genetics of exceptional longevity. Cold Spring Harbor Laboratory Press. 2007.
Annual Review of Gerontology And Geriatrics: Biopsychosocial Approaches to Longevity (Poon L, Perls T, Eds.). Springer. 2007.

Perls TT. Hope drives antiaging hype. Cleve Clin J Med. 2006 Dec; 73(12):1039-40, 1044. PMID: 17190307

Schoenhofen EA, Wyszynski DF, Andersen S, Pennington J, Young R, Terry DF, Perls TT. Characteristics of 32 supercentenarians. J Am Geriatr Soc. 2006 Aug; 54(8):1237-40.View Related Profiles.

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PMID: 16913991; PMCID: PMC2895458; DOI: 10.1111/j.1532-5415.2006.00826.x;

Perls TT. The different paths to 100. Am J Clin Nutr. 2006 Feb; 83(2):484S-487S. PMID: 16470017

Perls T. Encyclopedia of Aging ( Schulz R, Noelker LS, Rockwood K, Sprott R, Eds.). Centenarians. Springer. 2006.
Perls T. Handbook of Models for Human Aging (Conn PM, Ed.). Human Models of Longevity. Elsevier. New York. 2006.

Perls T. The different paths to age one hundred. Ann N Y Acad Sci. 2005 Dec; 1055:13-25. PMID: 16387714

Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. PMID: 16264422; PMCID: PMC1371037; DOI: 10.1038/sj.embor.7400555;

Perls TT, Reisman NR, Olshansky SJ. Provision or distribution of growth hormone for "antiaging": clinical and legal issues. JAMA. 2005 Oct 26; 294(16):2086-90. PMID: 16249424

Li-Sucholeiki XC, Hu G, Perls T, Tomita-Mitchell A, Thilly WG. Scanning the beta-globin gene for mutations in large populations by denaturing capillary and gel electrophoresis. Electrophoresis. 2005 Jun; 26(13):2531-8. PMID: 15948210

Andersen SL, Terry DF, Wilcox MA, Babineau T, Malek K, Perls TT. Cancer in the oldest old. Mech Ageing Dev. 2005 Feb; 126(2):263-7.View Related Profiles.

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PMID: 15621206

Terry DF, Wilcox MA, McCormick MA, Pennington JY, Schoenhofen EA, Andersen SL, Perls TT. Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring. J Am Geriatr Soc. 2004 Dec; 52(12):2074-6.View Related Profiles.

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PMID: 15571545

Bernstein AM, Willcox BJ, Tamaki H, Kunishima N, Suzuki M, Willcox DC, Yoo JS, Perls TT. First autopsy study of an Okinawan centenarian: absence of many age-related diseases. J Gerontol A Biol Sci Med Sci. 2004 Nov; 59(11):1195-9. PMID: 15602075

Perls T. Dementia-free centenarians. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1587-93. PMID: 15582273

Perls T. Centenarians who avoid dementia. Trends Neurosci. 2004 Oct; 27(10):633-6. PMID: 15374676

Perls TT. Anti-aging quackery: human growth hormone and tricks of the trade--more dangerous than ever. J Gerontol A Biol Sci Med Sci. 2004 Jul; 59(7):682-91. PMID: 15304532

Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, Asea A. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N Y Acad Sci. 2004 Jun; 1019:502-5.View Related Profiles.

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PMID: 15247074; PMCID: PMC1764488

Mor V, Perls TT. Robine and Michel's "Looking forward to a general theory on population aging": measuring functional decline in population aging in a changing world and an evolving biology. J Gerontol A Biol Sci Med Sci. 2004 Jun; 59(6):M609-11; author reply M616-20. PMID: 15215279

Olshansky SJ, Hayflick L, Perls TT. The hype and the reality--part I. J Gerontol A Biol Sci Med Sci. 2004 Jun; 59(6):B513-4. PMID: 15215255

Terry DF, Wilcox MA, McCormick MA, Perls TT. Cardiovascular disease delay in centenarian offspring. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):385-9.View Related Profiles.

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Perls T, Terry D. Principles and Practice of Geriatric Medicine (Pathy MSJ, Morley JE, Sinclair A, Eds.). Centenarians. Wiley. Chichester, England. 2004.

Geesaman BJ, Benson E, Brewster SJ, Kunkel LM, Blanché H, Thomas G, Perls TT, Daly MJ, Puca AA. Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14115-20. PMID: 14615589; PMCID: PMC283555

Perls T, Terry D. Understanding the determinants of exceptional longevity. Ann Intern Med. 2003 Sep 2; 139(5 Pt 2):445-9.View Related Profiles.

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Butler RN, Austad SN, Barzilai N, Braun A, Helfand S, Larsen PL, McCormick AM, Perls TT, Shuldiner AR, Sprott RL, Warner HR. Longevity genes: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci. 2003 Jul; 58(7):581-4. PMID: 12865472

Perls T, Terry D. Genetics of exceptional longevity. Exp Gerontol. 2003 Jul; 38(7):725-30.View Related Profiles.

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Perls, Thomas

PMID: 12855277

Terry DF, Wilcox M, McCormick MA, Lawler E, Perls TT. Cardiovascular advantages among the offspring of centenarians. J Gerontol A Biol Sci Med Sci. 2003 May; 58(5):M425-31.View Related Profiles.

Terry, Dellara
Perls, Thomas

PMID: 12730251

Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003 Mar; 58(3):232-7. PMID: 12634289

Arking R, Butler B, Chiko B, Fossel M, Gavrilov LA, Morley JE, Olshansky SJ, Perls T, Walker RF. Anti-aging teleconference: what is anti-aging medicine? J Anti Aging Med. 2003; 6(2):91-106. PMID: 14614799

Butler RN, Fossel M, Harman SM, Heward CB, Olshansky SJ, Perls TT, Rothman DJ, Rothman SM, Warner HR, West MD, Wright WE. Is there an antiaging medicine? J Gerontol A Biol Sci Med Sci. 2002 Sep; 57(9):B333-8. PMID: 12196485

Perls T, Kunkel LM, Puca AA. The genetics of exceptional human longevity. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):233-8. PMID: 12212788

Perls T, Puca A. The genetics of aging-- implications for pharmacogenomics. Pharmacogenomics. 2002 Jul; 3(4):469-84. PMID: 12164771

Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul; 77(7):681-96. PMID: 12108606

Perls TT, Wilmoth J, Levenson R, Drinkwater M, Cohen M, Bogan H, Joyce E, Brewster S, Kunkel L, Puca A. Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8442-7. PMID: 12060785; PMCID: PMC123086

Perls T, Kunkel L, Puca A. The genetics of aging. Curr Opin Genet Dev. 2002 Jun; 12(3):362-9. PMID: 12076681

Silver MH, Newell K, Brady C, Hedley-White ET, Perls TT. Distinguishing between neurodegenerative disease and disease-free aging: correlating neuropsychological evaluations and neuropathological studies in centenarians. Psychosom Med. 2002 May-Jun; 64(3):493-501. PMID: 12021423

Perls T. Genetic and environmental influences on exceptional longevity and the AGE nomogram. Ann N Y Acad Sci. 2002 Apr; 959:1-13. PMID: 11976180

Perls T, Kunkel LM, Puca AA. The genetics of exceptional human longevity. J Am Geriatr Soc. 2002 Feb; 50(2):359-68. PMID: 12028221

Perls T, Levenson R, Regan M, Puca A. What does it take to live to 100? Mech Ageing Dev. 2002 Jan; 123(2-3):231-42. PMID: 11718815

Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10505-8. PMID: 11526246; PMCID: PMC56990

Perls TT, Fretts RC. The evolution of menopause and human life span. Ann Hum Biol. 2001 May-Jun; 28(3):237-45. PMID: 11393331

Silver MH, Jilinskaia E, Perls TT. Cognitive functional status of age-confirmed centenarians in a population-based study. J Gerontol B Psychol Sci Soc Sci. 2001 May; 56(3):P134-40. PMID: 11316831

Vijg J, Perls T, Franceschi C, van Orsouw NJ. BRCA1 gene sequence variation in centenarians. Ann N Y Acad Sci. 2001 Apr; 928:85-96. PMID: 11795532

Perls T. Genetic and phenotypic markers among centenarians. J Gerontol A Biol Sci Med Sci. 2001 Feb; 56(2):M67-70. PMID: 11213277

Newell KL, Silver MH, Perls TT, Hedley-Whyte ET. Envejecimiento cerebral y enfermedad (Martinez Lage JM, Hachinski V, Eds.). What centenarians teach us about neuropathology. Editorial Triacastela. Madrid. 2001; 31-46.

Perls T, Shea-Drinkwater M, Bowen-Flynn J, Ridge SB, Kang S, Joyce E, Daly M, Brewster SJ, Kunkel L, Puca AA. Exceptional familial clustering for extreme longevity in humans. J Am Geriatr Soc. 2000 Nov; 48(11):1483-5. PMID: 11083328

Perls T, Daly M, Brewster S, Puca A, Kunkel L. Sex and Longevity: Sexuality, Gender, Reproduction, Parenthood (Robine JM, Kirkwood TBL, Allard M, Eds.). Genes and Centenarians. Springer Verlag. Heidelberg. 2000; 43-57.
Perls T, Terry D, Silver M, Shea M, Bowen J, Joyce E, Ridge SB, Fretts R, Daly M, Brewster S, Puca A, Kunkel L. Molecular Genetics of Aging (Hekimi S, Ed.). Centenarians and The Genetics of Longevity. Springer. Germany. 2000; 29:1-20.

Perls T, Terry DF, Silver M, Shea M, Bowen J, Joyce E, Ridge SB, Fretts R, Daly M, Brewster S, Puca A, Kunkel L. Centenarians and the genetics of longevity. Results Probl Cell Differ. 2000; 29:1-20.View Related Profiles.

Terry, Dellara
Perls, Thomas

PMID: 10838692

Hitt R, Young-Xu Y, Silver M, Perls T. Centenarians: the older you get, the healthier you have been. Lancet. 1999 Aug 21; 354(9179):652. PMID: 10466675

Khrapko K, Bodyak N, Thilly WG, van Orsouw NJ, Zhang X, Coller HA, Perls TT, Upton M, Vijg J, Wei JY. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res. 1999 Jun 1; 27(11):2434-41. PMID: 10325435; PMCID: PMC148812

Perls T, Silver M, Lauerman J. Living to 100: Lessons In Living to Your Maximum Potential At Any Age. Basic Books. New York. 1999.

Perls TT, Bochen K, Freeman M, Alpert L, Silver MH. Validity of reported age and centenarian prevalence in New England. Age Ageing. 1999 Mar; 28(2):193-7. PMID: 10350418

Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer. Lancet. 1998 May 23; 351(9115):1560. PMID: 10326548

Silver M, Newell K, Hyman B, Growdon J, Hedley-Whyte ET, Perls T. Unraveling the mystery of cognitive changes in old age: correlation of neuropsychological evaluation with neuropathological findings in the extreme old. Int Psychogeriatr. 1998 Mar; 10(1):25-41. PMID: 9629522

Perls TT, Bochen K, Freeman M, Alpert L, Silver MH. Age Validation of the Extreme Old (Jeune B, Vaupel J, Eds.). The New England Centenarian Study: validity of reported age and prevalence of centenarians in an eight town sample. Odense University Press. Odense. 1998.
Alpert L, Vaupel J, Perls T. Age Validation of the Extreme Old. ( Jeune B, Vaupel J, Eds.). Extreme longevity in a family. A report of multiple centenarians within a single generation. Odense University Press. Odense. 1998.

Perls TT. Centenarians prove the compression of morbidity hypothesis, but what about the rest of us who are genetically less fortunate? Med Hypotheses. 1997 Nov; 49(5):405-7. PMID: 9421805

Perls TT, Alpert L, Fretts RC. Middle-aged mothers live longer. Nature. 1997 Sep 11; 389(6647):133. PMID: 9296486

Perls TT. Acute care costs of the oldest old. Hosp Pract (1995). 1997 Jul 15; 32(7):123-4, 129-32, 137. PMID: 9227662

Perls TT, Wood ER. Acute care costs of the oldest old: they cost less, their care intensity is less, and they go to nonteaching hospitals. Arch Intern Med. 1996 Apr 8; 156(7):754-60. PMID: 8615708

Gomez-Isla T, West HL, Rebeck GW, Harr SD, Growdon JH, Locascio JJ, Perls TT, Lipsitz LA, Hyman BT. Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann Neurol. 1996 Jan; 39(1):62-70. PMID: 8572669

Perls TT, Mace N, Morris J. The HRCA Manual (Lipsitz LA, Morris J, Murphy K, Eds.). Cognitive Loss and Dementia in Quality Care for the Nursing Home Resident. Eliot Press. Natick, MA. 1996.

Perls TT. Apolipoprotein E and its association with Alzheimer's disease. J Insur Med. 1996; 28(2):114-8. PMID: 10172880

Perls TT, Herget M. Higher respiratory infection rates on an Alzheimer's special care unit and successful intervention. J Am Geriatr Soc. 1995 Dec; 43(12):1341-4. PMID: 7490383

Perls TT. The oldest old. Sci Am. 1995 Jan; 272(1):70-5. PMID: 7824916

Rebeck GW, Perls TT, West HL, Sodhi P, Lipsitz LA, Hyman BT. Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology. 1994 Aug; 44(8):1513-6. PMID: 8058160

Perls TT, Morris JN, Ooi WL, Lipsitz LA. The relationship between age, gender and cognitive performance in the very old: the effect of selective survival. J Am Geriatr Soc. 1993 Nov; 41(11):1193-201. PMID: 8227893

Castle SC, Norman DC, Perls TT, Chang MP, Yoshikawa TT, Makinodan T. Analysis of cutaneous delayed-type hypersensitivity reaction and T cell proliferative response in elderly nursing home patients: an approach to identifying immunodeficient patients. Gerontology. 1990; 36(4):217-29. PMID: 2272525

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 202 publications over 33 distinct years, with a maximum of 12 publications in 2021

Bar chart showing 202 publications over 33 distinct years, with a maximum of 12 publications in 2021

Year	Publications
1990	1
1993	1
1994	1
1995	2
1996	4
1997	3
1998	4
1999	4
2000	4
2001	6
2002	10
2003	7
2004	10
2005	5
2006	5
2007	6
2008	8
2009	6
2010	3
2011	4
2012	8
2013	8
2014	5
2015	11
2016	10
2017	7
2018	7
2019	11
2020	6
2021	12
2022	7
2023	7
2024	9

Media Mentions

Recent (within 3 months)

Who gets to live to 100? The answer may surprise you.

The Boston Globe 12/4/2024

What’s the secret to living to 100? Centenarian stem cells could offer clues

Nature 11/29/2024

Massachusetts’ oldest resident dies at 113

The Boston Globe 11/18/2024

Want to live to 100 or older? Experts in Miami suggest taking these five steps now

Miami Herald 10/24/2024

As the US population ages, these states have the most older residents

KTVZ 10/15/2024

Jimmy Carter turns 100: 7 longevity habits of the oldest living president

Today Show 9/30/2024

Older

Americans would rather live a shorter life in good health than a longer life with health issues, new poll finds

CNBC 5/3/2024

The Secrets of Living to 100

The Brink 2/21/2024

Meet the Superstars of Aging: Centenarians

Managed Healthcare Executives 2/5/2024

Over One Hundred Years Strong Through the Eyes of Two Centenarians

Sampan 1/12/2024

How to Work—and Love It—Into Your 80s and Beyond

Wall Street Journal 12/29/2023

This Is What 100 Looks Like

AARP 11/26/2023

Celebrating What's Right With Aging: Inside the Minds of Super Agers

AARP 11/10/2023

Want to live to 100 or older? Experts in Miami suggest taking these five steps now

Miami Herald 10/31/2023

People Who Live to 100 Have These 3 Things in Common, New Research Shows

Best Life 10/25/2023

Some scientists seriously believe we could live forever by the 2030s. Here's what you need to know about the 'longevity escape velocity' theory.

Insider 10/20/2023

This Is the #1 Surprising Thing That Helps With Weight Loss After Age 50, According to a Geriatrician

Parade 6/24/2023

America aged rapidly in the last decade as baby boomers grew older and births dropped

Associated Press 5/25/2023

Golden oldies? Number of seniors surged in 2020 census data, lifting the median age in US

USA Today 5/25/2023

Los Altos centenarian studied for longevity research

Los Altos Town Crier 5/16/2023

Cracking an intriguing secret of centenarians: Why so few are ravaged by Alzheimer’s disease

The Boston Globe 5/6/2023

Age, Inflation, Abortion, Culture Wars, and More: Issues That Will Define President Biden’s Reelection Campaign

BU Today 4/26/2023

Improving Diagnosis, Screening Patients More Efficiently in Alzheimer Disease: Katherine Turk, MD

Neurology Live 4/25/2023

World's oldest leaders

The World 4/25/2023

The importance of lifestyle choices in aging gracefully and living past 100

WWLTV 2/23/2023

More people are living to be 100: Here’s why

The Hill 2/7/2023

Column: What’s so great about living to 100?

Los Angeles Times 12/11/2022

Study hopes to unlock the secret of ageless aging

Boston 25 News 11/28/2022

The secret to longer, healthier life? Ambitious new trial focuses on ‘super agers’ and seeks thousands of families.

The Boston Globe 11/27/2022

5 daily practices could up your chances of living to 90—check out this life expectancy calculator to see more

CNBC 11/18/2022

Forget Wordle. Here are 5 secrets to living better, longer

The Boston Globe 10/13/2022

Why Do Some People Live to 100—and How

BU Today 9/12/2022

'Medical Methuselahs': Treating the Growing Population of Centenarians

Medscape 8/16/2022

Old age isn't a modern phenomenon. Many people lived long enough to grow old in the olden days, too

The Buffalo News 8/13/2022

Why 80 is the new 60: 'It's the triumph of aging' — but not for everyone

Ottawa Citizen 8/8/2022

Never Take This After Age 50, Warn Pharmacists

Eat This, Not That! 6/7/2022

World’s-oldest person dies

The World 4/26/2022

Want to live to 100? Here’s what the latest longevity research says

MarketWatch 4/9/2022

Why Some People Live to 110

Medicine Net 1/8/2022

Down the Rabbit Hole: The genetics of exceptional longevity – Tom Perls

Front Line Genomics 12/14/2021

"Forever Young: Searching for the Fountain of Youth"

CBS 11/28/2021

The Science That Could Help You Live to 100

WIRED 10/22/2021

The Secrets of ‘Cognitive Super-Agers’

The New York Times 6/21/2021

Living longer: Secrets of being a super-centenarians living to 100 plus

Communities Digital News 5/11/2021

This is how to have a long awesome life: 7 secrets from research

The Ladders 4/29/2021

Age-Related Cognitive Decline May Not Be Inevitable

WebMD 4/7/2021

Age-Related Cognitive Decline Not Inevitable?

Medscape 4/6/2021

Why more of us are living to 100

MPR 4/5/2021

High Cognitive Performance at Age 100

Medpage Today 1/15/2021

In Hamden, Edna McCabe celebrates 110th birthday

New Haven Register 12/1/2020

Best face mask for any occasion, according to experts

NBC News 9/14/2020

New York’s true nursing home death toll cloaked in secrecy

Associated Press 8/11/2020

You Docs

Garden City Telegram 8/7/2020

Drs. Oz & Roizen: Making older years healthy; preventing aging on a cellular level

The Union Leader 8/1/2020

Want to Live to 100? These Centenarians Are Sharing Their Secrets to Long Life

Parade 6/19/2020

Nursing Homes a Hotspot for COVID-19 Deaths

WebMD 6/5/2020

Venerable by vulnerable: Centenarians hit hard by virus

Business Mirror 5/16/2020

Venerable But Vulnerable: Centenarians Hit Hard by Virus

The Associated Press 5/7/2020

Dartmouth Officials: Coronavirus is ‘Manageable’ in the Town

South Coast Today 5/2/2020

Failure to Count COVID-19 Nursing Home Deaths Could Dramatically Skew US Numbers

The Conversation 4/27/2020

The CDC now recommends wearing a mask in some cases – a physician explains why and when to wear one

The Conversation 4/6/2020

Doctor explains how and when you should be wearing a face mask

CBS News 4/6/2020

Social distancing isn’t the right language for what Covid-19 asks of us

Quartz 4/3/2020

Should we wear masks or not? An expert sorts through the confusion

The Conversation 4/1/2020

Social distancing: What it is and why it’s the best tool we have to fight the coronavirus

The Conversation 3/13/2020

The Wild West of Anti-Aging Medicine

Medscape 7/11/2019

Alelia Murphy, Oldest Living American, Turns 114 Years Old in Harlem

Today 7/8/2019

This is How to Have a Long Awesome Life: 7 Secrets from Research

The Ladders 4/28/2019

We’re living longer and happier in the 21st Century, says AMAC

The Times of Noblesville 4/20/2019

Beyond The Wall: Living Long

The Brandon Sun 3/21/2019

San Antonio Centenarians Reveal Secrets of Longevity

San Antonio Express-News 2/10/2019

This is how to have a long awesome life: 7 secrets from research

Ladders 1/19/2019

A Brief Tour Of Boston’s Anti-Aging Industry

The Boston Globe 12/11/2018

London's Chelsea Pensioners prove the right genetics are crucial for living beyond 100

Wired 5/4/2018

Alcohol and coffee (in modest amounts) linked to long life, some experts say

Today 2/28/2018

'One of society’s greatest achievements' — in a simple chart of the past 175 years

Yahoo 6/19/2015

2017 Gerontological Society of America: Fellow

2016 Gerontological Society of America: Joseph T. Freeman Award

2013 International Gerontology Association World Congress: Ewald Busse Research in Gerontology

2010 Glenn Medical Research Foundation: Glenn Award for Resaerch in Biological Mechanisms of Aging

1993 American College of Physicians: Fellow

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

aging
centenarian
exceptional longevity

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Advisor
Career Mentor
Co-Mentor or Peer Mentor
Research / Scholarly Mentor

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Phone (see 'Contact Info')

72 E. Concord St Robinson (B)
Boston MA 02118
Google Map

617.353.2050

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