Philip C. Trackman, PhD
Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Molecular & Cell Biology

PhD, Boston University



Dr. Philip Trackman is a Professor and the Director of Graduate Programs in the Department of Molecular and Cell Biology at the Boston University Henry M. Goldman School of Dental Medicine. Dr. Trackman is also an important member of the Oral Cancer Research Initiative (OCRI) and is currently investigating the molecular mechanisms of the connective tissue enzyme, lysyl oxidase, and its potential therapeutic effects in oral cancer.

Dr. Trackman became interested in cancer research in 1990, after cloning lysyl oxidase for the very first time. This enzyme family has tumor inhibitory properties and also enhances tissue fibrosis and metastasis. In the context of the OCRI, Dr. Trackman is working to investigate the two therapeutic opportunities which these findings suggest. His first aim is to explore how to inhibit the harmful activity of the active enzymes, while taking advantage of the tumor growth inhibitory activity of the lysyl oxidase propeptide. The lysyl oxidase propeptide was shown by Dr. Trackman’s lab in 2004 to be responsible for the tumor growth inhibitory properties of lysyl oxidase. His lab has confirmed this in animal models of both breast and prostate cancer, and recently also in oral cancer. Dr. Trackman collaborated on this project with Research Assistant Professor Dr. Manish Bais, who is also an OCRI investigator.

Dr. Trackman’s ongoing research will establish the extent to which new and powerful lysyl oxidase family enzyme activity inhibitors can block human oral cancer tumor growth and/or metastasis in mice. This work is funded by the OCRI’s Etiology and Pathogenesis of Oral Cancer Affinity Research Collaborative (ARC) as a part of Boston University’s Evans Center for Interdisciplinary Biomedical Research. In addition, modifications to the structure of the lysyl oxidase propeptide are underway with the goal of enhancing its tumor growth inhibitory properties, and also to identify its most important binding partners in its ability to inhibit tumor growth. This research is supported by funding from the NIH.

Director of Graduate Programs, Molecular & Cell Biology
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology


Research Assistant Professor
Boston University School of Medicine
Biochemistry


Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences



2013 PloS One: Academic Editor
1997-2011 Listed in Marquis Who’s Who in Science and Engineering
1981-1983 Brandeis University: American Cancer Society Postdoctoral Fellow
1977-1980 Boston University School of Medicine: Predoctoral NIH Traineeship
1975 American Chemical Society : Outstanding Senior Award


MECHANISM OF BONE MARROW NEOPLASM-INDUCED OSTEOSCLEROSIS
05/01/2018 - 04/30/2020 (Multi-PI)
PI: Philip C. Trackman, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R21AR072748-01

BIOLOGICAL ACTIVIT OF LYSYL OXIDASE LIKE-2 INHIBITORS
04/01/2015 - 12/31/2017 (PI)
Pharmaxis

CELLULAR OR EXTRACELLULAR TARGETING OF LYSYL OXIDASE PROPEPTIDE FOR ORAL CANCER
07/01/2014 - 06/30/2017 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R21DE023973-02

INHIBITED INTRAMEMBRANEOUS BONE HEALING IN DIABETES
03/01/2009 - 01/31/2016 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R01DE014066-10

Growth Factors and Gingival Fibrosis
04/01/1994 - 06/30/2012 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE11004 15

Lysyl Oxidase Inhibition of Ras-Mediated Transformation
09/01/1999 - 04/30/2010 (Co-PI)
NIH/National Cancer Institute
5 R01 CA82742 10

Mechanisms of Mineralized Matrix Accumulation
02/01/1999 - 01/31/2004 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE12209 04

Screen Fibrogen anti-CTGF Antibodies for Blocking Activity
05/15/2001 - 05/14/2002 (PI)
FibroGen Inc

Phenotypic Reversion Requires Lysyl Oxidase mRNA
09/15/1998 - 09/14/2000 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R03 DE12425 02




Yr Title Project-Sub Proj Pubs
2018 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 1R21AR072748-01
2014 Cellular or Extracellular Targeting of Lysyl Oxidase Propeptide for Oral Cancer 1R21DE023973-01A1 3
2013 Inhibited Intramembranous Bone Healing in Diabetes 5R01DE014066-10 28
2012 Inhibited Intramembranous Bone Healing in Diabetes 5R01DE014066-09 28
2011 Inhibited Intramembranous Bone Healing in Diabetes 5R01DE014066-08 28
2011 Growth Factors and Gingival Fibrosis 5R01DE011004-15 11
2010 Inhibited Intramembranous Bone Healing in Diabetes 5R01DE014066-07 28
2010 Growth Factors and Gingival Fibrosis 5R01DE011004-14 11
2009 Inhibited Intramembranous Bone Healing in Diabetes 2R01DE014066-06A2 28
2009 Growth Factors and Gingival Fibrosis 5R01DE011004-13 11
Showing 10 of 37 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. de la Cueva A, Emmerling M, Lim SL, Yang S, Trackman PC, Sonenshein GE, Kirsch KH. A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer. Carcinogenesis. 2018 Jul 03; 39(7):921-930.View Related Profiles. PMID: 29579155.
     
  2. Saxena D, Mahjour F, Findlay AD, Mously EA, Kantarci A, Trackman PC. Multiple Functions of Lysyl Oxidase Like-2 in Oral Fibroproliferative Processes. J Dent Res. 2018 Oct; 97(11):1277-1284.View Related Profiles. PMID: 29787337.
     
  3. Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC. Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016. J Dent Res. 2018 May; 97(5):483-491. PMID: 29328868.
     
  4. Trackman PC. Functional importance of lysyl oxidase family propeptide regions. J Cell Commun Signal. 2018 Mar; 12(1):45-53. PMID: 29086201.
     
  5. Trackman PC, Bais MV. Measurement of lysyl oxidase activity from small tissue samples and cell cultures. Methods Cell Biol. 2018; 143:147-156.View Related Profiles. PMID: 29310775.
     
  6. Bais MV, Kukuruzinska M, Trackman PC. Corrigendum to "Orthotopic non-metastatic and metastatic oral cancer mouse models" [Oral Oncol. 51(5) (2015) 476-482]. Oral Oncol. 2017 09; 72:201.View Related Profiles. PMID: 28743466.
     
  7. Kim D, Mecham RP, Trackman PC, Roy S. Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis. Invest Ophthalmol Vis Sci. 2017 May 01; 58(5):2725-2731.View Related Profiles. PMID: 28538980.
     
  8. Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. J Cell Biochem. 2017 Aug; 118(8):2347-2356.View Related Profiles. PMID: 28106301; DOI: 10.1002/jcb.25893;.
     
  9. Trackman PC, Saxena D, Bais MV. TGF-ß1- and CCN2-Stimulated Sirius Red Assay for Collagen Accumulation in Cultured Cells. Methods Mol Biol. 2017; 1489:481-485.View Related Profiles. PMID: 27734398.
     
  10. Trackman PC. Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer. Expert Opin Ther Targets. 2016 Aug; 20(8):935-45. PMID: 26848785; PMCID: PMC4988797; DOI: 10.1517/14728222.2016.1151003;.
     
Showing 10 of 109 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 107 publications over 33 distinct years, with a maximum of 7 publications in 2006 and 2007 and 2010 and 2015

YearPublications
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700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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