Keith Tornheim | Profiles RNS

Keith Tornheim, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Brandeis University
BS, Antioch College

Keith Tornheim, PhD, began his career at the Chobanian and Avedisian School of Medicine in 1981 as an assistant professor. Since then he has published over fifty articles, mainly on the topic of metabolism. He originally studied spontaneous oscillatory behavior of glycolysis in muscle extracts. Dr. Tornheim is currently in the Biochemistry teaching mission, teaching metabolism to first-year medical, dental and graduate students.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston Medical Center

BU Research
NIH RePORTER Research

Phosphofructokinase-M and Adipose Mass
04/01/2005 - 03/31/2008 (PI)
Boston Medical Center NIH NIDDK

Phosphofructokinase and Oscillatory Insulin Secretion
03/01/2002 - 02/28/2006 (PI)
Juvenile Diabetes Foundation International

Metabolic Oscillations and Insulin Secretion
07/01/1997 - 06/30/2002 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R01 DK53064 04

Title

Yr	Title	Project-Sub Proj	Pubs
2000	METABOLIC OSCILLATIONS AND INSULIN SECRETION	5R01DK053064-04	12
1999	METABOLIC OSCILLATIONS AND INSULIN SECRETION	5R01DK053064-03	12
1998	METABOLIC OSCILLATIONS AND INSULIN SECRETION	5R01DK053064-02	12
1997	METABOLIC OSCILLATIONS AND INSULIN SECRETION	1R01DK053064-01	12
1994	OSCILLATIONS AND THE CONTROL OF GLYCOLYSIS	5R01DK031559-10	21
1993	OSCILLATIONS AND THE CONTROL OF GLYCOLYSIS	5R01DK031559-09	21
1992	OSCILLATIONS AND THE CONTROL OF GLYCOLYSIS	5R01DK031559-08	21
1991	OSCILLATIONS AND THE CONTROL OF GLYCOLYSIS	2R01DK031559-07A3	21
1988	OSCILLATIONS AND THE CONTROL OF GLYCOLYSIS	5R01DK031559-06	21
1987	OSCILLATIONS AND THE CONTROL OF GLYCOLYSIS	5R01DK031559-05	21

Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Martínez-Costa OH, Sánchez V, Lázaro A, Hernández ED, Tornheim K, Aragón JJ. Distinct functional roles of the two terminal halves of eukaryotic phosphofructokinase. Biochem J. 2012 Jul 15; 445(2):213-8. PMID: 22530721; DOI: 10.1042/BJ20120173;

Haller JF, Smith C, Liu D, Zheng H, Tornheim K, Han GS, Carman GM, Zoeller RA. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase. J Biol Chem. 2010 Jan 8; 285(2):866-77.View Related Profiles.

Tornheim, Keith
Zoeller, Raphael

PMID: 19903819; PMCID: PMC2801288; DOI: 10.1074/jbc.M109.068213;

Getty-Kaushik L, Viereck JC, Goodman JM, Guo Z, LeBrasseur NK, Richard AM, Flanagan JN, Yaney GC, Hamilton JA, Tornheim K. Mice deficient in phosphofructokinase-M have greatly decreased fat stores. Obesity (Silver Spring). 2010 Mar; 18(3):434-40.View Related Profiles.

Hamilton, James
Tornheim, Keith

PMID: 19779479; PMCID: PMC2871150; DOI: 10.1038/oby.2009.295;

Richard AM, Webb DL, Goodman JM, Schultz V, Flanagan JN, Getty-Kaushik L, Deeney JT, Yaney GC, Dunaway GA, Berggren PO, Tornheim K. Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E794-801.View Related Profiles.

Deeney, Jude
Tornheim, Keith

PMID: 17595219

Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith
Shirihai, Orian

PMID: 17181533; PMCID: PMC1828901; DOI: 10.1042/BJ20061209;

Nascimben L, Ingwall JS, Lorell BH, Pinz I, Schultz V, Tornheim K, Tian R. Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension. 2004 Nov; 44(5):662-7. PMID: 15466668

Juntti-Berggren L, Webb DL, Arkhammar PO, Schultz V, Schweda EK, Tornheim K, Berggren PO. Dihydroxyacetone-induced oscillations in cytoplasmic free Ca2+ and the ATP/ADP ratio in pancreatic beta-cells at substimulatory glucose. J Biol Chem. 2003 Oct 17; 278(42):40710-6. PMID: 12917415

Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul; 52(7):1635-40.View Related Profiles.

Saha, Asish
Tornheim, Keith
Ruderman, Neil

PMID: 12829626

Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J. 2003 Jan 1; 369(Pt 1):173-8.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 12356335; PMCID: PMC1223070

Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE. Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E880-8.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 12376314

Showing 10 of 77 results. Show More

Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 11832341

Deeney JT, Köhler M, Kubik K, Brown G, Schultz V, Tornheim K, Corkey BE, Berggren PO. Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior. J Biol Chem. 2001 Oct 5; 276(40):36946-50.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 11481328

Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem. 2001 Sep 28; 276(39):36695-702.View Related Profiles.

Corkey, Barbara
Tornheim, Keith

PMID: 11443115

Dagher Z, Ruderman N, Tornheim K, Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res. 2001 Jun 22; 88(12):1276-82.View Related Profiles.

Tornheim, Keith
Ruderman, Neil
Ido, Yasuo

PMID: 11420304

Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62.View Related Profiles.

Corkey, Barbara
Hamilton, James
Deeney, Jude
Tornheim, Keith

PMID: 11147795

Porterfield DM, Corkey RF, Sanger RH, Tornheim K, Smith PJ, Corkey BE. Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT). Diabetes. 2000 Sep; 49(9):1511-6.View Related Profiles.

Corkey, Barbara
Tornheim, Keith

PMID: 10969835

Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem. 2000 Aug 11; 275(32):24279-83.View Related Profiles.

Saha, Asish
Tornheim, Keith
Ruderman, Neil

PMID: 10854420

Corkey BE, Deeney JT, Yaney GC, Tornheim K, Prentki M. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr. 2000 Feb; 130(2S Suppl):299S-304S.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 10721892

Dagher Z, Ruderman N, Tornheim K, Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1999 Nov; 265(1):112-5.View Related Profiles.

Tornheim, Keith
Ruderman, Neil
Ido, Yasuo

PMID: 10548499

Liu YQ, Tornheim K, Leahy JL. Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets. Diabetes. 1999 Sep; 48(9):1747-53. PMID: 10480604

Garrett GS, McPhail SJ, Tornheim K, Correa PE, McIver JM. Synthesis of potent and selective inhibitors of human plasma kallikrein. Bioorg Med Chem Lett. 1999 Feb 8; 9(3):301-6. PMID: 10091673

Liu YQ, Tornheim K, Leahy JL. Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity. Diabetes. 1998 Dec; 47(12):1889-93. PMID: 9836520

Garrett GS, Correa PE, McPhail SJ, Tornheim K, Burton JA, Eickhoff DJ, Engerholm GG, McIver JM. Peptide aldehyde inhibitors of the kallikreins: an investigation of subsite interactions with tripeptides containing structural variations at the amino terminus. J Pept Res. 1998 Jul; 52(1):60-71. PMID: 9716252

Liu YQ, Tornheim K, Leahy JL. Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content. J Clin Invest. 1998 May 1; 101(9):1870-5. PMID: 9576750; PMCID: PMC508772

Tornheim K. Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes. 1997 Sep; 46(9):1375-80. PMID: 9287034

Prentki M, Tornheim K, Corkey BE. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia. 1997 Jul; 40 Suppl 2:S32-41.View Related Profiles.

Corkey, Barbara
Tornheim, Keith

PMID: 9248699

Civelek VN, Deeney JT, Fusonie GE, Corkey BE, Tornheim K. Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. Diabetes. 1997 Jan; 46(1):51-6.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 8971081; PMCID: PMC3346292

Cunningham BA, Deeney JT, Bliss CR, Corkey BE, Tornheim K. Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT). Am J Physiol. 1996 Oct; 271(4 Pt 1):E702-10.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 8897858

Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10139-44.View Related Profiles.

Corkey, Barbara
Hamilton, James
Tornheim, Keith

PMID: 8816765; PMCID: PMC38350

Civelek VN, Deeney JT, Shalosky NJ, Tornheim K, Hansford RG, Prentki M, Corkey BE. Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. Biochem J. 1996 Sep 1; 318 ( Pt 2):615-21.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 8809055; PMCID: PMC1217665

Civelek VN, Deeney JT, Kubik K, Schultz V, Tornheim K, Corkey BE. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J. 1996 May 1; 315 ( Pt 3):1015-9.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 8645138; PMCID: PMC1217255

Nilsson T, Schultz V, Berggren PO, Corkey BE, Tornheim K. Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cells. Biochem J. 1996 Feb 15; 314 ( Pt 1):91-4.View Related Profiles.

Corkey, Barbara
Tornheim, Keith

PMID: 8660314; PMCID: PMC1217056

Kim NN, Kim JJ, Hypolite J, García-Díaz JF, Broderick GA, Tornheim K, Daley JT, Levin R, Saenz de Tejada I. Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol. 1996 Feb; 155(2):772-8.View Related Profiles.

Garcia-Diaz, Jesus
Tornheim, Keith

PMID: 8558723

Ito Y, Pagano PJ, Tornheim K, Brecher P, Cohen RA. Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta. Am J Physiol. 1996 Jan; 270(1 Pt 2):H81-7.View Related Profiles.

Tornheim, Keith
Brecher, Peter
Cohen, Richard

PMID: 8769737

Yaney GC, Schultz V, Cunningham BA, Dunaway GA, Corkey BE, Tornheim K. Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1). Diabetes. 1995 Nov; 44(11):1285-9.View Related Profiles.

Corkey, Barbara
Tornheim, Keith

PMID: 7589825

Pagano PJ, Ito Y, Tornheim K, Gallop PM, Tauber AI, Cohen RA. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2274-80.View Related Profiles.

Tauber, Alfred
Tornheim, Keith
Cohen, Richard

PMID: 7611477

Shimazaki J, Tsubota K, Yoshida A, Tornheim K, Laing RA. Changes of corneal redox state in diabetic animal models. Cornea. 1995 Mar; 14(2):196-201. PMID: 7743804

Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994 Aug 19; 269(33):20852-6.View Related Profiles.

Corkey, Barbara
Hamilton, James
Tornheim, Keith

PMID: 8063701

Tornheim K. Kinetic applications using high substrate and competitive inhibitor concentrations to determine Ki or Km. Anal Biochem. 1994 Aug 15; 221(1):53-6. PMID: 7985803

Hocker CG, Epstein IR, Kustin K, Tornheim K. Glycolytic pH oscillations in a flow reactor. Biophys Chem. 1994 Jul; 51(1):21-35. PMID: 8061224

Juntti-Berggren L, Civelek VN, Berggren PO, Schultz V, Corkey BE, Tornheim K. Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic beta-cells. A possible role for pyruvate. J Biol Chem. 1994 May 20; 269(20):14391-5.View Related Profiles.

Corkey, Barbara
Tornheim, Keith

PMID: 8182044

Schultz V, Sussman I, Bokvist K, Tornheim K. Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP. Anal Biochem. 1993 Dec; 215(2):302-4. PMID: 8122794

Sussman I, Schultz V, Gupta S, Grady C, Ruderman NB, Tornheim K. Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. Am J Physiol. 1993 Nov; 265(5 Pt 1):E777-82.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 7902010

Pagano PJ, Tornheim K, Cohen RA. Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide. Am J Physiol. 1993 Aug; 265(2 Pt 2):H707-12.View Related Profiles.

Tornheim, Keith
Cohen, Richard

PMID: 7690193

Tornheim K, Schultz V. Specific enzymatic spectrophotometric assay of adenosine 5'-diphosphate. Anal Biochem. 1993 Jun; 211(2):329-30. PMID: 8317712

Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE. Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells. J Biol Chem. 1992 Oct 5; 267(28):19840-5.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 1400300

Gupta S, Sussman I, McArthur CS, Tornheim K, Cohen RA, Ruderman NB. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest. 1992 Sep; 90(3):727-32.View Related Profiles.

Tornheim, Keith
Ruderman, Neil
Cohen, Richard

PMID: 1325996; PMCID: PMC329923

Tornheim K, Andrés V, Schultz V. Modulation by citrate of glycolytic oscillations in skeletal muscle extracts. J Biol Chem. 1991 Aug 25; 266(24):15675-8. PMID: 1831450

Longo EA, Tornheim K, Deeney JT, Varnum BA, Tillotson D, Prentki M, Corkey BE. Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J Biol Chem. 1991 May 15; 266(14):9314-9.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith

PMID: 1902835

Andrés V, Schultz V, Tornheim K. Oscillatory synthesis of glucose 1,6-bisphosphate and frequency modulation of glycolytic oscillations in skeletal muscle extracts. J Biol Chem. 1990 Dec 15; 265(35):21441-7. PMID: 2254306

Tornheim K, Schultz V. Adenosine diphosphate and adenosine monophosphate: enzymatic spectrophotometric determination. J Nutr Biochem. 1990 Aug; 1(8):440-4. PMID: 15539235

Tornheim K, Schultz V. Adenosine triphosphate: enzymatic spectrophotometric determination. J Nutr Biochem. 1990 Mar; 1(3):172-6. PMID: 15539201

Gaposchkin CG, Tornheim K, Sussman I, Ruderman NB, McCall AL. Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels. Am J Physiol. 1990 Mar; 258(3 Pt 1):E543-7.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 2316646

Shimazaki J, Tornheim K, Laing RA. Correlation of redox fluorometry and analytical measurements of pyridine nucleotide. Invest Ophthalmol Vis Sci. 1989 Oct; 30(10):2274-8. PMID: 2793366

Sussman I, Carson MP, Schultz V, Wu XP, McCall AL, Ruderman NB, Tornheim K. Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium. Diabetologia. 1988 Oct; 31(10):771-5.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 3240840

McCall AL, Valente J, Cordero R, Ruderman NB, Tornheim K. Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations. Microvasc Res. 1988 May; 35(3):325-33.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 3393093

Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith
Ruderman, Neil

PMID: 2831225

McCall AL, Sussman I, Tornheim K, Cordero R, Ruderman NB. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. Am J Physiol. 1988 Mar; 254(3 Pt 1):E272-8.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 2964787

Sussman I, Carson MP, McCall AL, Schultz V, Ruderman NB, Tornheim K. Energy state of bovine cerebral microvessels: comparison of isolation methods. Microvasc Res. 1988 Mar; 35(2):167-78.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 2897072

Tornheim K. Fructose 2,6-bisphosphate and glycolytic oscillations in skeletal muscle extracts. J Biol Chem. 1988 Feb 25; 263(6):2619-24. PMID: 2963814

McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB. Chronic hypoglycemia increases brain glucose transport. Am J Physiol. 1986 Oct; 251(4 Pt 1):E442-7.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 3532819

Tornheim K, Pang H, Costello CE. The purine nucleotide cycle and ammoniagenesis in rat kidney tubules. J Biol Chem. 1986 Aug 5; 261(22):10157-62. PMID: 2874138

Tornheim K. Activation of muscle phosphofructokinase by fructose 2,6-bisphosphate and fructose 1,6-bisphosphate is differently affected by other regulatory metabolites. J Biol Chem. 1985 Jul 5; 260(13):7985-9. PMID: 3159721

Tornheim K, Lowenstein LM. Effect of acidosis and uninephrectomy on isozymes of adenylosuccinate synthetase in rat kidney. Biochim Biophys Acta. 1983 May 4; 757(1):137-9. PMID: 6838904

Aragón JJ, Tornheim K, Goodman MN, Lowenstein JM. Replenishment of citric acid cycle intermediates by the purine nucleotide cycle in rat skeletal muscle. Curr Top Cell Regul. 1981; 18:131-49. PMID: 6456135

Aragón JJ, Tornheim K, Lowenstein JM. On a possible role of IMP in the regulation of phosphorylase activity in skeletal muscle. FEBS Lett. 1980 Aug 25; 117 Suppl:K56-64. PMID: 6774892

Tornheim K. Co-ordinate control of phosphofructokinase and pyruvate kinase by fructose diphosphate: a mechanism for amplification and step changes in the regulation of glycolysis in liver. J Theor Biol. 1980 Jul 21; 85(2):199-222. PMID: 6448938

Tornheim K, Gilbert TR, Lowenstein JM. Metal contaminants in commercial preparations of nucleotides. Anal Biochem. 1980 Mar 15; 103(1):87-93. PMID: 7377548

Tornheim K, Lowenstein JM. Creatine phosphate inhibition of heart lactate dehydrogenase and muscle pyruvate kinase is due to a contaminant. J Biol Chem. 1979 Nov 10; 254(21):10586-7. PMID: 574139

Tornheim K. Oscillations of the glycolytic pathway and the purine nucleotide cycle. J Theor Biol. 1979 Aug 21; 79(4):491-541. PMID: 159983

Tornheim K, Lowenstein JM. Control of phosphofructokinase from rat skeletal muscle. Effects of fructose diphosphate, AMP, ATP, and citrate. J Biol Chem. 1976 Dec 10; 251(23):7322-8. PMID: 12161

Tornheim K, Lowenstein JM. The purine nucleotide cycle. Control of phosphofructokinase and glycolytic oscillations in muscle extracts. J Biol Chem. 1975 Aug 25; 250(16):6304-14. PMID: 169235

Tornheim K, Lowenstein JM. The purine nucleotide cycle. IV. Interactions with oscillations of the glycolytic pathway in muscle extracts. J Biol Chem. 1974 May 25; 249(10):3241-7. PMID: 4275340

Tornheim K, Lowenstein JM. The purine nucleotide cycle. 3. Oscillations in metabolite concentrations during the operation of the cycle in muscle extracts. J Biol Chem. 1973 Apr 25; 248(8):2670-7. PMID: 4348916

Tornheim K, Lowenstein JM. The purine nucleotide cycle. The production of ammonia from aspartate by extracts of rat skeletal muscle. J Biol Chem. 1972 Jan 10; 247(1):162-9. PMID: 5017762

Lowenstein J, Tornheim K. Ammonia production in muscle: the purine nucleotide cycle. Science. 1971 Jan 29; 171(3969):397-400. PMID: 4249969

Tornheim K, O'Dell RG, Prosky L. Effects of cycloheximide on DNA and protein synthesis in rat liver. Proc Soc Exp Biol Med. 1969 Jun; 131(2):601-5. PMID: 5787143

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 68 publications over 25 distinct years, with a maximum of 7 publications in 1996