Karen R. Jacobson, MD, MPH
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine
MPH, Harvard School of Public Health
BS, Yale University



Dr. Karen Jacobson is an Associate Professor of Medicine in the Section of Infectious Diseases, Chobanian and Avedisian School of Medicine, with a secondary appointment in the Department of Epidemiology, Boston University School of Public Health. Dr. Jacobson’s research focuses on the epidemiology of tuberculosis, including identification of biological and social determinants of and risk factors for tuberculosis infection and disease (including drug resistant tuberculosis) and approaches for improving tuberculosis outcomes in resource-limited settings. Dr. Jacobson is the Medical Director of the Boston Medical Center Tuberculosis Clinic and has established a highly productive collaboration with researchers in Cape Town, South Africa. Her work has particular emphasis in understanding how substance use impacts on tuberculosis transmission and response to therapy.

Diversity, Equity, Inclusion and Accessibility

I am an infectious disease physician and researcher committed to improving health outcomes for historically underrepresented populations in resource-limited high-burden settings and in our BMC community around Boston.

As a clinician, I serve as the Medical Director of the BMC Tuberculosis (TB) Clinic where I guide and provide direct patient care for a population primarily made up of recent immigrants from many parts of the world. I am part of a group of clinicians committed to offering and
developing standard operating procedures for cutting edge regimens and offering this to all who come for care.

As a researcher, my work focuses on the epidemiology of TB, including identification of biological and social determinants of and risk factors for TB infection and disease and approaches for improving TB outcomes in resource-limited, high-burden settings. Through two ongoing studies based in Worcester, South Africa, my team’s research has been able to investigate the interplay between illicit smoked substances and TB transmission and alcohol use and TB treatment outcomes, focusing on two key populations who are vulnerable to stigma and marginalization. I aim to treat our participants with respect and inclusion and to learn from them as partners.

My commitment to diversity, equity, inclusion and accessibility is visible through my interest in training and mentoring new investigators in our BU/BMC community, including helping trainees and junior faculty identify their own niches and grow a diverse workforce committed to focusing on research that will improve healthcare outcomes and equity.

Associate Professor
Boston University School of Public Health
Epidemiology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Assessing the effects of HIV disease on TB and type 2 diabetes mellitus in a TB patient cohort in Western Cape Province, South Africa
01/01/2021 - 12/31/2021 (Key Person / Mentor)
Providence/Boston Center for AIDS Research NIH NIAID



Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics
09/22/2020 - 08/31/2024 (PI)
Harvard Medical School National Institute o

Administrative Supplement to Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)
08/01/2023 - 07/31/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
5R01AI147316-05

Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)
08/01/2019 - 07/31/2024 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R01AI147316-01

Core L - The Providence/Boston Center for AIDS Research (CFAR) competitive renewal
07/01/2023 - 06/30/2024 (PI)
The Miriam Hospital National Institute o

Evaluating the tuberculosis epidemic in South Africa using a novel ten year national cohort
04/13/2020 - 03/31/2024 (Multi-PI)
PI: Karen R. Jacobson, MD, MPH
DMMH - A Division of WITS Health Consortium National Institute o
1R01AI152126-01

MassCPR COVID biorepository work
10/01/2021 - 12/31/2023 (PI)
Harvard Medical School China Evergrande Gr

Providence Boston Center for AIDS Research (CFAR)
07/01/2019 - 06/30/2023 (Multi-PI)
PI: Karen R. Jacobson, MD, MPH
The Miriam Hospital National Institute o
5P30AI042853-24

Deep sequencing of pathogens to precisely define transmission networks using rare variants
06/01/2021 - 05/31/2023 (PI)
Harvard School of Public Health National Institute o
5R01AI128344-05

The impact of alcohol consumption on TB treatment outcomes
04/01/2020 - 03/31/2023 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
5R01AI119037-04

Evidence of the burden of diabetes, gaps in the diabetes cascade-of-care and the impact of care and treatment on diabetes outcomes in HIV-positive and HIV-negative patients in South Africa
06/01/2021 - 08/31/2022 (PI)
Boston University School of Public Health National Institute o
3K01DK116929-03S1

Showing 10 of 19 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2023 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-05
2022 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-04
2022 SWG1: HIV/TB Scientific Working Group 5P30AI042853-24-7401
2021 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-03
2021 SWG1: HIV/TB Scientific Working Group 5P30AI042853-23-7401 905
2020 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-02
2020 The impact of alcohol consumption on TB treatment outcomes 5R01AI119037-05 3
2020 SWG1: HIV/TB Scientific Working Group 5P30AI042853-22-7401 905
2019 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 1R01AI147316-01
2019 The impact of alcohol consumption on TB treatment outcomes 5R01AI119037-04 3
Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Marin MG, Wippel C, Quinones-Olvera N, Behruznia M, Jeffrey BM, Harris M, Mann BC, Rosenthal A, Jacobson KR, Warren RM, Li H, Meehan CJ, Farhat MR. Analysis of the limited M. tuberculosis accessory genome reveals potential pitfalls of pan-genome analysis approaches. bioRxiv. 2024 Mar 25. PMID: 38585972; PMCID: PMC10996470; DOI: 10.1101/2024.03.21.586149;
     
  2. Shapiro AN, Scott L, Moultrie H, Jacobson KR, Bor J, Fofana AM, Dor G, Ndjeka NO, da Silva P, Mlisana K, Jenkins HE, Stevens WS. Tuberculosis testing patterns in South Africa to identify groups that would benefit from increased investigation. Sci Rep. 2023 Nov 27; 13(1):20875.View Related Profiles. PMID: 38012266; PMCID: PMC10682361; DOI: 10.1038/s41598-023-47148-y;
     
  3. Scott LE, Shapiro AN, Da Silva MP, Tsoka J, Jacobson KR, Emch M, Moultrie H, Jenkins HE, Moore D, Van Rie A, Stevens WS. Integrating Molecular Diagnostics and GIS Mapping: A Multidisciplinary Approach to Understanding Tuberculosis Disease Dynamics in South Africa Using Xpert MTB/RIF. Diagnostics (Basel). 2023 Oct 10; 13(20).View Related Profiles. PMID: 37891984; PMCID: PMC10606157; DOI: 10.3390/diagnostics13203163;
     
  4. Kulkarni S, Weber SE, Buys C, Lambrechts T, Myers B, Drainoni ML, Jacobson KR, Theron D, Carney T. Patient and provider perceptions of the relationship between alcohol use and TB and readiness for treatment: a qualitative study in South Africa. Res Sq. 2023 Sep 25.View Related Profiles. PMID: 37841852; PMCID: PMC10571641; DOI: 10.21203/rs.3.rs-3290185/v1;
     
  5. Mann BC, Jacobson KR, Ghebrekristos Y, Warren RM, Farhat MR. Assessment and validation of enrichment and target capture approaches to improve Mycobacterium tuberculosis WGS from direct patient samples. J Clin Microbiol. 2023 Oct 24; 61(10):e0038223. PMID: 37728909; PMCID: PMC10595060; DOI: 10.1128/jcm.00382-23;
     
  6. Acuña-Villaorduña C, Jacobson KR, Horsburgh CR, Canning M, Sinha P. Initial experience with BPaL-based regimens to treat multidrug-resistant TB. Int J Tuberc Lung Dis. 2023 Aug 01; 27(8):649-650. PMID: 37491751; PMCID: PMC10365559; DOI: 10.5588/ijtld.23.0185;
     
  7. Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR, Salgame P, Alland D, Barry CE, Flynn JL, Ellner JJ, Wilkinson RJ. High resolution imaging and five-year tuberculosis contact outcomes. medRxiv. 2023 Jul 03. PMID: 37461515; PMCID: PMC10350144; DOI: 10.1101/2023.07.03.23292111;
     
  8. Myers B, Carney T, Rooney J, Malatesta S, Ragan EJ, White LF, Natcheva H, Bouton TC, Weber SE, Farhat M, McIlleron H, Theron D, Parry CDH, Horsburgh CR, Warren RM, Jacobson KR. Smoked drug use in patients with TB is associated with higher bacterial burden. Int J Tuberc Lung Dis. 2023 Jun 01; 27(6):444-450.View Related Profiles. PMID: 37231597; PMCID: PMC10407961; DOI: 10.5588/ijtld.22.0650;
     
  9. Hahn JA, Ngabirano C, Fatch R, Emenyonu NI, Cheng DM, Adong J, Tumwegamire A, Terrault NA, Linas BP, Jacobson KR, Muyindike WR. Safety and tolerability of isoniazid preventive therapy for tuberculosis for persons with HIV with and without alcohol use. AIDS. 2023 Aug 01; 37(10):1535-1543.View Related Profiles. PMID: 37260251; PMCID: PMC10355800; DOI: 10.1097/QAD.0000000000003613;
     
  10. Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson AJ, Zhang M, Jacobson KR, Gupta A, Manabe YC, Hosseinipour MC, Kumwenda J, Sagar M. Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses. iScience. 2023 May 19; 26(5):106631.View Related Profiles. PMID: 37168567; PMCID: PMC10165194; DOI: 10.1016/j.isci.2023.106631;
     
Showing 10 of 73 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 73 publications over 16 distinct years, with a maximum of 13 publications in 2023

YearPublications
19992
20021
20101
20111
20122
20133
20152
20162
20173
20188
20195
20206
202112
202211
202313
20241
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

alcohol
drug resistant tuberculosis
global health
spatial mapping
tuberculosis

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

771 Albany St
Boston MA 02118
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