Karen R. Jacobson, MD, MPH
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Infectious Diseases

MD, Johns Hopkins University School of Medicine
MPH, Harvard School of Public Health
BS, Yale University

Dr. Karen Jacobson is an Associate Professor of Medicine in the Section of Infectious Diseases, Chobanian and Avedisian School of Medicine, with a secondary appointment in the Department of Epidemiology, Boston University School of Public Health. Dr. Jacobson’s research focuses on the epidemiology of tuberculosis, including identification of biological and social determinants of and risk factors for tuberculosis infection and disease (including drug resistant tuberculosis) and approaches for improving tuberculosis outcomes in resource-limited settings. Dr. Jacobson is the Medical Director of the Boston Medical Center Tuberculosis Clinic and has established a highly productive collaboration with researchers in Cape Town, South Africa. Her work has particular emphasis in understanding how substance use impacts on tuberculosis transmission and response to therapy.

Diversity, Equity, Inclusion and Accessibility

I am an infectious disease physician and researcher committed to improving health outcomes for historically underrepresented populations in resource-limited high-burden settings and in our BMC community around Boston.

As a clinician, I serve as the Medical Director of the BMC Tuberculosis (TB) Clinic where I guide and provide direct patient care for a population primarily made up of recent immigrants from many parts of the world. I am part of a group of clinicians committed to offering and
developing standard operating procedures for cutting edge regimens and offering this to all who come for care.

As a researcher, my work focuses on the epidemiology of TB, including identification of biological and social determinants of and risk factors for TB infection and disease and approaches for improving TB outcomes in resource-limited, high-burden settings. Through two ongoing studies based in Worcester, South Africa, my team’s research has been able to investigate the interplay between illicit smoked substances and TB transmission and alcohol use and TB treatment outcomes, focusing on two key populations who are vulnerable to stigma and marginalization. I aim to treat our participants with respect and inclusion and to learn from them as partners.

My commitment to diversity, equity, inclusion and accessibility is visible through my interest in training and mentoring new investigators in our BU/BMC community, including helping trainees and junior faculty identify their own niches and grow a diverse workforce committed to focusing on research that will improve healthcare outcomes and equity.

Associate Professor
Boston University School of Public Health

Boston University
Evans Center for Interdisciplinary Biomedical Research

Assessing the effects of HIV disease on TB and type 2 diabetes mellitus in a TB patient cohort in Western Cape Province, South Africa
01/01/2021 - 12/31/2021 (Key Person / Mentor)
Providence/Boston Center for AIDS Research NIH NIAID

Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)
08/01/2019 - 07/31/2024 (PI)

Providence/Boston Center for AIDS Research(CFAR): HIV-TB SWG
07/01/2018 - 06/30/2023 (PI)
The Miriam Hospital National Institute o

MassCPR COVID biorepository work
10/01/2021 - 09/30/2022 (PI)
Harvard Medical School China Evergrande Gr

Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics
09/22/2020 - 08/31/2022 (PI)
Harvard Medical School National Institutes

Deep sequencing of pathogens to precisely define transmissio
06/01/2021 - 05/31/2022 (PI)
Harvard School of Public Health National Institute o

an Evergrande COVID-19 Response Fund Award from the Massachusetts Consortium on Pathogen Readiness (“MassCPR”)
05/01/2020 - 04/30/2022 (PI)
Harvard Medical School China Evergrande Gr

Competitive Revision to Existing NIH Grants NIGMS - Predictive Models for the Spread of…
04/01/2020 - 03/31/2022 (PI)
Trustees of Boston University NIH-NIGMS

The impact of alcohol consumption on TB treatment outcomes
04/08/2016 - 03/31/2022 (PI)

URBAN ARCH (3/5) Uganda Cohort- TB prevention therapy for HIV-infected alcohol drinkers in Uganda…
09/22/2016 - 08/31/2021 (PI)
The Regents of the University of California NIH-NIAAA

Biomarkers and Mechanisms of Paucibacillary and Latent Tuberculosis
11/01/2018 - 07/31/2021 (PI)
Rutgers The State University of New Jersey NIH-NIAID

Showing 10 of 16 results. Show All Results


Yr Title Project-Sub Proj Pubs
2023 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-05
2022 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-04
2022 SWG1: HIV/TB Scientific Working Group 5P30AI042853-24-7401
2021 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-03
2021 SWG1: HIV/TB Scientific Working Group 5P30AI042853-23-7401 905
2020 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 5R01AI147316-02
2020 The impact of alcohol consumption on TB treatment outcomes 5R01AI119037-05 3
2020 SWG1: HIV/TB Scientific Working Group 5P30AI042853-22-7401 905
2019 Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL) 1R01AI147316-01
2019 The impact of alcohol consumption on TB treatment outcomes 5R01AI119037-04 3
Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Acuña-Villaorduña C, Jacobson KR, Horsburgh CR, Canning M, Sinha P. Initial experience with BPaL-based regimens to treat multidrug-resistant TB. Int J Tuberc Lung Dis. 2023 Aug 01; 27(8):649-650.View Related Profiles. PMID: 37491751; PMCID: PMC10365559; DOI: 10.5588/ijtld.23.0185;
  2. Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR, Salgame P, Alland D, Barry CE, Flynn JL, Ellner JJ, Wilkinson RJ. High resolution imaging and five-year tuberculosis contact outcomes. medRxiv. 2023 Jul 03.View Related Profiles. PMID: 37461515; PMCID: PMC10350144; DOI: 10.1101/2023.07.03.23292111;
  3. Myers B, Carney T, Rooney J, Malatesta S, Ragan EJ, White LF, Natcheva H, Bouton TC, Weber SE, Farhat M, McIlleron H, Theron D, Parry CDH, Horsburgh CR, Warren RM, Jacobson KR. Smoked drug use in patients with TB is associated with higher bacterial burden. Int J Tuberc Lung Dis. 2023 Jun 01; 27(6):444-450.View Related Profiles. PMID: 37231597; PMCID: PMC10407961; DOI: 10.5588/ijtld.22.0650;
  4. Hahn JA, Ngabirano C, Fatch R, Emenyonu NI, Cheng DM, Adong J, Tumwegamire A, Terrault NA, Linas BP, Jacobson KR, Muyindike WR. Safety and tolerability of isoniazid preventive therapy for tuberculosis for persons with HIV with and without alcohol use. AIDS. 2023 Aug 01; 37(10):1535-1543.View Related Profiles. PMID: 37260251; PMCID: PMC10355800; DOI: 10.1097/QAD.0000000000003613;
  5. Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson AJ, Zhang M, Jacobson KR, Gupta A, Manabe YC, Hosseinipour MC, Kumwenda J, Sagar M. Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses. iScience. 2023 May 19; 26(5):106631.View Related Profiles. PMID: 37168567; PMCID: PMC10165194; DOI: 10.1016/j.isci.2023.106631;
  6. Sinha P, Jacobson KR, Horsburgh CR, Acuña-Villaorduña C. At Long Last: Short, All-Oral Regimens for Multidrug-Resistant Tuberculosis in the United States. Open Forum Infect Dis. 2023 Apr; 10(4):ofad177.View Related Profiles. PMID: 37125228; PMCID: PMC10135426; DOI: 10.1093/ofid/ofad177;
  7. Fofana AM, Moultrie H, Scott L, Jacobson KR, Shapiro AN, Dor G, Crankshaw B, Silva PD, Jenkins HE, Bor J, Stevens WS. Cross-municipality migration and spread of tuberculosis in South Africa. Sci Rep. 2023 Feb 15; 13(1):2674.View Related Profiles. PMID: 36792792; PMCID: PMC9930008; DOI: 10.1038/s41598-023-29804-5;
  8. Bouton TC, Atarere J, Turcinovic J, Seitz S, Sher-Jan C, Gilbert M, White L, Zhou Z, Hossain MM, Overbeck V, Doucette-Stamm L, Platt J, Landsberg HE, Hamer DH, Klapperich C, Jacobson KR, Connor JH. Viral Dynamics of Omicron and Delta Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants With Implications for Timing of Release from Isolation: A Longitudinal Cohort Study. Clin Infect Dis. 2023 Feb 08; 76(3):e227-e233.View Related Profiles. PMID: 35737948; PMCID: PMC9278204; DOI: 10.1093/cid/ciac510;
  9. Petros BA, Turcinovic J, Welch NL, White LF, Kolaczyk ED, Bauer MR, Cleary M, Dobbins ST, Doucette-Stamm L, Gore M, Nair P, Nguyen TG, Rose S, Taylor BP, Tsang D, Wendlandt E, Hope M, Platt JT, Jacobson KR, Bouton T, Yune S, Auclair JR, Landaverde L, Klapperich CM, Hamer DH, Hanage WP, MacInnis BL, Sabeti PC, Connor JH, Springer M. Early Introduction and Rise of the Omicron Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant in Highly Vaccinated University Populations. Clin Infect Dis. 2023 Feb 08; 76(3):e400-e408.View Related Profiles. PMID: 35616119; PMCID: PMC9213864; DOI: 10.1093/cid/ciac413;
  10. Muyindike WR, Fatch R, Cheng DM, Emenyonu NI, Forman L, Ngabirano C, Adong J, Linas B, Jacobson KR, Hahn JA. Unhealthy Alcohol Use Is Associated With Suboptimal Adherence to Isoniazid Preventive Therapy in Persons With HIV in Southwestern Uganda. J Acquir Immune Defic Syndr. 2022 Dec 15; 91(5):460-468.View Related Profiles. PMID: 36044285; PMCID: PMC9649866; DOI: 10.1097/QAI.0000000000003082;
Showing 10 of 67 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 15 distinct years, with a maximum of 12 publications in 2021

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

drug resistant tuberculosis
global health
spatial mapping

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

771 Albany St
Boston MA 02118
Google Map

Jacobson's Networks
Click the "See All" links for more information and interactive visualizations
Media Mentions
Similar People
Same Department