Karen Jacobson | Profiles RNS

Karen R. Jacobson, MD, MPH

Associate Professor

Boston University School of Medicine

Dept of Medicine

Infectious Diseases

MD, Johns Hopkins University School of Medicine
MPH, Harvard School of Public Health

Websites

	Infectious Diseases Faculty
	Boston Medical Center Provider Profile

ORCID : 0000-0003-4239-3685

Dr. Karen Jacobson is an Associate Professor of Medicine in the Section of Infectious Diseases, Boston University School of Medicine, with a secondary appointment in the Department of Epidemiology, Boston University School of Public Health. Dr. Jacobson’s research focuses on the epidemiology of tuberculosis, including identification of biological and social determinants of and risk factors for tuberculosis infection and disease (including drug resistant tuberculosis) and approaches for improving tuberculosis outcomes in resource-limited settings. Dr. Jacobson is the Medical Director of the Boston Medical Center Tuberculosis Clinic and has established a highly productive collaboration with researchers in Cape Town, South Africa. Her work has particular emphasis in understanding how substance use impacts on tuberculosis transmission and response to therapy.

Assistant Professor
Boston University School of Public Health
Epidemiology

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BMC Research
NIH RePORTER Research

Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)
08/01/2019 - 07/31/2024 (PI)
NIH-NIAID
1R01AI147316-01

Providence/Boston Center for AIDS Research(CFAR): HIV-TB SWG
07/01/2018 - 06/30/2023 (PI)
Miriam Hospital NIH-NIAID

Biomarkers and Mechanisms of Paucibacillary and Latent Tuberculosis
11/01/2018 - 07/31/2021 (PI)
Rutgers The State University of New Jersey NIH-NIAID

The impact of alcohol consumption on TB treatment outcomes
04/08/2016 - 03/31/2021 (PI)
NIH-NIAID
5R01AI119037-04

URBAN ARCH (3/5) Uganda Cohort- TB prevention therapy for HIV-infected alcohol drinkers in Uganda…
09/22/2016 - 08/31/2020 (PI)
The Regents of the University of California NIH-NIAAA

ASTMH Fellowship in Tropical Infectious Diseases
02/01/2013 - 11/30/2018 (PI)
American Society of Tropical Medicine and Hygiene

Phase 2 Pharmacodynamic Study of Hidh-dose Levofloxacin in MDR-TB Treatment
01/01/2015 - 07/31/2018 (PI)
Trustees of Boston University NIH-NIAID

Lifespan/Tufts/Brown Center for AIDS Research(CFAR): SWG1
07/01/2017 - 06/30/2018 (PI)
Miriam Hospital NIH-NIAID

Geospatial clustering and molecular and social epidemiology of drug resistant TB
08/01/2013 - 12/31/2016 (PI)
NIH-FIC
5K01TW009213-6

Title

Yr	Title	Project-Sub Proj	Pubs
2020	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-05	3
2020	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-05	3
2019	Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)	1R01AI147316-01
2019	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-04	3
2019	SWG1: HIV/TB Scientific Working Group	5P30AI042853-21-7401	905
2018	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-03	3
2018	SWG1: HIV/TB Scientific Working Group	2P30AI042853-20A1-7401	905
2017	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-02	3
2016	The impact of alcohol consumption on TB treatment outcomes	1R01AI119037-01A1	3
2015	Geospatial clustering and molecular and social epidemiology of drug resistant TB	5K01TW009213-06	10

Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Eddy JJ, Gadani KM, Tibbs A, Bernardo J, Cochran J, White LF, Horsburgh CR, Jacobson KR. Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009-2018. Open Forum Infect Dis. 2020 Aug; 7(8):ofaa300.View Related Profiles.

Horsburgh, C.
Bernardo, John
Jacobson, Karen
White, Laura

PMID: 32855987

Muyindike WR, Fatch R, Cheng DM, Emenyonu NI, Ngabirano C, Adong J, Linas BP, Jacobson KR, Hahn JA. Tuberculin skin test positivity among HIV-infected alcohol drinkers on antiretrovirals in south-western Uganda. PLoS One. 2020; 15(7):e0235261.View Related Profiles.

Linas, Benjamin
Cheng, Debbie
Jacobson, Karen

PMID: 32614873

He X, Eddy JJ, Jacobson KR, Henderson AJ, Agosto LM. Enhanced HIV-1 Replication in CD4+ T Cells Derived from Individuals with Latent Mycobacterium tuberculosis Infection. J Infect Dis. 2020 May 16.View Related Profiles.

Henderson, Andrew
Jacobson, Karen
He, Xianbao

PMID: 32417884

Bouton TC, Jacobson KR. Symptom screens are not sufficient: the fight against tuberculosis needs better weapons. Clin Infect Dis. 2020 Apr 16.View Related Profiles.

Jacobson, Karen
Bouton, Tara

PMID: 32296819

Ragan EJ, Kleinman MB, Sweigart B, Gnatienko N, Parry CD, Horsburgh CR, LaValley MP, Myers B, Jacobson KR. The impact of alcohol use on tuberculosis treatment outcomes: a systematic review and meta-analysis. Int J Tuberc Lung Dis. 2020 01 01; 24(1):73-82.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
LaValley, Michael

PMID: 32005309

Bouton TC, de Vos M, Ragan EJ, White LF, Van Zyl L, Theron D, Horsburgh CR, Warren RM, Jacobson KR. Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis. PLoS One. 2019; 14(10):e0223308.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 31622366

Bulabula ANH, Nelson JA, Musafiri EM, Machekano R, Sam-Agudu NA, Diacon AH, Shah M, Creswell J, Theron G, Warren RM, Jacobson KR, Chirambiza JP, Kalumuna D, Bisimwa BC, Katoto PDMC, Kaswa MK, Birembano FM, Kitete L, Grobusch MP, Kashongwe ZM, Nachega JB. Prevalence, Predictors, and Successful Treatment Outcomes of Xpert MTB/RIF-identified Rifampicin-resistant Tuberculosis in Post-conflict Eastern Democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study. Clin Infect Dis. 2019 09 27; 69(8):1278-1287. PMID: 30759187

van der Heijden YF, Hughes J, Dowdy DW, Streicher E, Chihota V, Jacobson KR, Warren R, Theron G. Overcoming limitations of tuberculosis information systems: researcher and clinician perspectives. Public Health Action. 2019 Sep 21; 9(3):120-127. PMID: 31803584

Berhanu RH, Schnippel K, Kularatne R, Firnhaber C, Jacobson KR, Horsburgh CR, Lippincott CK. Discordant rifampicin susceptibility results are associated with Xpert® MTB/RIF probe B and probe binding delay. Int J Tuberc Lung Dis. 2019 03 01; 23(3):358-362.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
Berhanu, Rebecca

PMID: 30940300

Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 11 01; 79(3):407-411.View Related Profiles.

Ellner, Jerrold
Jacobson, Karen
Sagar, Manish
Lin, Nina

PMID: 30063648

Showing 10 of 34 results. Show More

Myers B, Bouton TC, Ragan EJ, White LF, McIlleron H, Theron D, Parry CDH, Horsburgh CR, Warren RM, Jacobson KR. Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol. BMC Infect Dis. 2018 Sep 29; 18(1):488.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 30268101

McIntosh AI, Jenkins HE, White LF, Barnard M, Thomson DR, Dolby T, Simpson J, Streicher EM, Kleinman MB, Ragan EJ, van Helden PD, Murray MB, Warren RM, Jacobson KR. Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis. PLoS Med. 2018 08; 15(8):e1002638.View Related Profiles.

Jenkins, Helen
Jacobson, Karen
White, Laura

PMID: 30130377

Berhanu RH, Schnippel K, Kularatne R, Firnhaber C, Jacobson KR, Horsburgh CR, Lippincott CK. Can patients afford the cost of treatment for multidrug-resistant tuberculosis in Ethiopia? Int J Tuberc Lung Dis. 2018 08 01; 22(8):358-362.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
Berhanu, Rebecca

PMID: 29991400

Geadas C, Acuna-Villaorduna C, Mercier G, Kleinman MB, Horsburgh CR, Ellner JJ, Jacobson KR. FDG-PET/CT activity leads to the diagnosis of unsuspected TB: a retrospective study. BMC Res Notes. 2018 Jul 13; 11(1):464.View Related Profiles.

Horsburgh, C.
Acuna-Villaorduna, Carlos
Mercier, Gustavo
Ellner, Jerrold
Jacobson, Karen

PMID: 30001743

Freiman JM, Jacobson KR, Muyindike WR, Horsburgh CR, Ellner JJ, Hahn JA, Linas BP. Isoniazid Preventive Therapy for People With HIV Who Are Heavy Alcohol Drinkers in High TB-/HIV-Burden Countries: A Risk-Benefit Analysis. J Acquir Immune Defic Syndr. 2018 04 01; 77(4):405-412.View Related Profiles.

Linas, Benjamin
Horsburgh, C.
Ellner, Jerrold
Freiman, Julie
Jacobson, Karen

PMID: 29239900

Fregonese F, Ahuja SD, Akkerman OW, Arakaki-Sanchez D, Ayakaka I, Baghaei P, Bang D, Bastos M, Benedetti A, Bonnet M, Cattamanchi A, Cegielski P, Chien JY, Cox H, Dedicoat M, Erkens C, Escalante P, Falzon D, Garcia-Prats AJ, Gegia M, Gillespie SH, Glynn JR, Goldberg S, Griffith D, Jacobson KR, Johnston JC, Jones-López EC, Khan A, Koh WJ, Kritski A, Lan ZY, Lee JH, Li PZ, Maciel EL, Galliez RM, Merle CSC, Munang M, Narendran G, Nguyen VN, Nunn A, Ohkado A, Park JS, Phillips PPJ, Ponnuraja C, Reves R, Romanowski K, Seung K, Schaaf HS, Skrahina A, Soolingen DV, Tabarsi P, Trajman A, Trieu L, Banurekha VV, Viiklepp P, Wang JY, Yoshiyama T, Menzies D. Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2018 04; 6(4):265-275. PMID: 29595509

Brooks-Pollock E, Jacobson KR. Rethinking tuberculosis control by targeting previously treated individuals. Lancet Glob Health. 2018 04; 6(4):e361-e362. PMID: 29472017

Farhat MR, Jacobson KR, Franke MF, Kaur D, Murray M, Mitnick CD. Fluoroquinolone Resistance Mutation Detection Is Equivalent to Culture-Based Drug Sensitivity Testing for Predicting Multidrug-Resistant Tuberculosis Treatment Outcome: A Retrospective Cohort Study. Clin Infect Dis. 2017 Oct 15; 65(8):1364-1370. PMID: 29017248

Jacobson KR, Barnard M, Kleinman MB, Streicher EM, Ragan EJ, White LF, Shapira O, Dolby T, Simpson J, Scott L, Stevens W, van Helden PD, Van Rie A, Warren RM. Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study. Clin Infect Dis. 2017 Jun 01; 64(11):1502-1508.View Related Profiles.

Jacobson, Karen
White, Laura

PMID: 28199520; DOI: 10.1093/cid/cix128;

Jacobson KR. Tuberculosis. Ann Intern Med. 2017 Feb 07; 166(3):ITC17-ITC32. PMID: 28166561; DOI: 10.7326/AITC201702070;

Farhat MR, Sultana R, Iartchouk O, Bozeman S, Galagan J, Sisk P, Stolte C, Nebenzahl-Guimaraes H, Jacobson K, Sloutsky A, Kaur D, Posey J, Kreiswirth BN, Kurepina N, Rigouts L, Streicher EM, Victor TC, Warren RM, van Soolingen D, Murray M. Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value. Am J Respir Crit Care Med. 2016 Sep 01; 194(5):621-30.View Related Profiles.

Galagan, James
Jacobson, Karen

PMID: 26910495; PMCID: PMC5027209; DOI: 10.1164/rccm.201510-2091OC;

Farhat MR, Jacobson KR, Franke MF, Kaur D, Sloutsky A, Mitnick CD, Murray M. Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis. J Clin Microbiol. 2016 Mar; 54(3):727-33. PMID: 26763957; PMCID: PMC4767988; DOI: 10.1128/JCM.02775-15;

Jacobson KR, Sabin LL. Scaling up multidrug-resistant tuberculosis care in China. Lancet Glob Health. 2015 Apr; 3(4):e183-4.View Related Profiles.

Jacobson, Karen
Sabin, Lora

PMID: 25794667; PMCID: PMC4492310; DOI: 10.1016/S2214-109X(15)70093-8;

Farhat MR, Mitnick CD, Franke MF, Kaur D, Sloutsky A, Murray M, Jacobson KR. Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment. Int J Tuberc Lung Dis. 2015 Mar; 19(3):339-41. PMID: 25686144; PMCID: PMC4486051; DOI: 10.5588/ijtld.14.0814;

Kendall EA, Theron D, Franke MF, van Helden P, Victor TC, Murray MB, Warren RM, Jacobson KR. Alcohol, hospital discharge, and socioeconomic risk factors for default from multidrug resistant tuberculosis treatment in rural South Africa: a retrospective cohort study. PLoS One. 2013; 8(12):e83480. PMID: 24349518; PMCID: PMC3862731; DOI: 10.1371/journal.pone.0083480;

Nebenzahl-Guimaraes H, Jacobson KR, Farhat MR, Murray MB. Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis. J Antimicrob Chemother. 2014 Feb; 69(2):331-42. PMID: 24055765; PMCID: PMC3886931; DOI: 10.1093/jac/dkt358;

Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, Kaur D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, Johnston JC, Rodrigues M, Tang PK, Kato-Maeda M, Borowsky ML, Muddukrishna B, Kreiswirth BN, Kurepina N, Galagan J, Gagneux S, Birren B, Rubin EJ, Lander ES, Sabeti PC, Murray M. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nat Genet. 2013 Oct; 45(10):1183-9.View Related Profiles.

Galagan, James
Jacobson, Karen

PMID: 23995135; DOI: 10.1038/ng.2747;

Jacobson KR, Theron D, Kendall EA, Franke MF, Barnard M, van Helden PD, Victor TC, Streicher EM, Murray MB, Warren RM. Implementation of genotype MTBDRplus reduces time to multidrug-resistant tuberculosis therapy initiation in South Africa. Clin Infect Dis. 2013 Feb; 56(4):503-8. PMID: 23090928; PMCID: PMC3552527; DOI: 10.1093/cid/cis920;

Mukinda FK, Theron D, van der Spuy GD, Jacobson KR, Roscher M, Streicher EM, Musekiwa A, Coetzee GJ, Victor TC, Marais BJ, Nachega JB, Warren RM, Schaaf HS. Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa. Int J Tuberc Lung Dis. 2012 Feb; 16(2):196-202. PMID: 22236920; PMCID: PMC3712259; DOI: 10.5588/ijtld.11.0116;

Jacobson KR, Theron D, Victor TC, Streicher EM, Warren RM, Murray MB. Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa. Clin Infect Dis. 2011 Aug; 53(4):369-72. PMID: 21810750; PMCID: PMC3202325; DOI: 10.1093/cid/cir406;

Jacobson KR, Tierney DB, Jeon CY, Mitnick CD, Murray MB. Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis. Clin Infect Dis. 2010 Jul 1; 51(1):6-14. PMID: 20504231; DOI: 10.1086/653115;

Jacobson KR, Murray K, Zellos A, Schwarz KB. An analysis of published trials of interferon monotherapy in children with chronic hepatitis C. J Pediatr Gastroenterol Nutr. 2002 Jan; 34(1):52-8. PMID: 11753165

Altemus M, Greenberg BD, Keuler D, Jacobson KR, Murphy DL. Open trial of flutamide for treatment of obsessive-compulsive disorder. J Clin Psychiatry. 1999 Jul; 60(7):442-5. PMID: 10453797

Altemus M, Jacobson KR, Debellis M, Kling M, Pigott T, Murphy DL, Gold PW. Normal CSF oxytocin and NPY levels in OCD. Biol Psychiatry. 1999 Apr 1; 45(7):931-3. PMID: 10202583

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 12 distinct years, with a maximum of 8 publications in 2018

Bar chart showing 34 publications over 12 distinct years, with a maximum of 8 publications in 2018

Year	Publications
1999	2
2002	1
2010	1
2011	1
2012	2
2013	3
2015	2
2016	2
2017	3
2018	8
2019	4
2020	5

Media Mentions

New method may allow real-time surveillance of drug-resistant TB

The Daily Star 8/19/2018

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

alcohol
drug resistant tuberculosis
global health
spatial mapping
tuberculosis

Available to Mentor as: (Review Mentor Role Definitions):