Karen Jacobson | Profiles RNS

Karen R. Jacobson, MD, MPH

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Infectious Diseases

MD, Johns Hopkins University School of Medicine
MPH, Harvard School of Public Health
BS, Yale University

Websites

	Infectious Diseases Faculty
	Boston Medical Center Provider Profile
	Jacobson Research Group

ORCID : 0000-0003-4239-3685

Dr. Karen Jacobson is an Associate Professor of Medicine in the Section of Infectious Diseases, Chobanian and Avedisian School of Medicine, with a secondary appointment in the Department of Epidemiology, Boston University School of Public Health. Dr. Jacobson’s research focuses on the epidemiology of tuberculosis, including identification of biological and social determinants of and risk factors for tuberculosis infection and disease (including drug resistant tuberculosis) and approaches for improving tuberculosis outcomes in resource-limited settings. Dr. Jacobson is the Medical Director of the Boston Medical Center Tuberculosis Clinic and has established a highly productive collaboration with researchers in Cape Town, South Africa. Her work has particular emphasis in understanding how substance use impacts on tuberculosis transmission and response to therapy.

Diversity, Equity, Inclusion and Accessibility

I am an infectious disease physician and researcher committed to improving health outcomes for historically underrepresented populations in resource-limited high-burden settings and in our BMC community around Boston.

As a clinician, I serve as the Medical Director of the BMC Tuberculosis (TB) Clinic where I guide and provide direct patient care for a population primarily made up of recent immigrants from many parts of the world. I am part of a group of clinicians committed to offering and
developing standard operating procedures for cutting edge regimens and offering this to all who come for care.

As a researcher, my work focuses on the epidemiology of TB, including identification of biological and social determinants of and risk factors for TB infection and disease and approaches for improving TB outcomes in resource-limited, high-burden settings. Through two ongoing studies based in Worcester, South Africa, my team’s research has been able to investigate the interplay between illicit smoked substances and TB transmission and alcohol use and TB treatment outcomes, focusing on two key populations who are vulnerable to stigma and marginalization. I aim to treat our participants with respect and inclusion and to learn from them as partners.

My commitment to diversity, equity, inclusion and accessibility is visible through my interest in training and mentoring new investigators in our BU/BMC community, including helping trainees and junior faculty identify their own niches and grow a diverse workforce committed to focusing on research that will improve healthcare outcomes and equity.

Associate Professor
Boston University School of Public Health
Epidemiology

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Assessing the effects of HIV disease on TB and type 2 diabetes mellitus in a TB patient cohort in Western Cape Province, South Africa
01/01/2021 - 12/31/2021 (Key Person / Mentor)
Providence/Boston Center for AIDS Research NIH NIAID

Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)
08/01/2019 - 07/31/2024 (PI)
NIH-NIAID
1R01AI147316-01

Providence/Boston Center for AIDS Research(CFAR): HIV-TB SWG
07/01/2018 - 06/30/2023 (PI)
The Miriam Hospital National Institute o
5P30AI042853-23

MassCPR COVID biorepository work
10/01/2021 - 09/30/2022 (PI)
Harvard Medical School China Evergrande Gr

Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics
09/22/2020 - 08/31/2022 (PI)
Harvard Medical School National Institutes

Deep sequencing of pathogens to precisely define transmissio
06/01/2021 - 05/31/2022 (PI)
Harvard School of Public Health National Institute o
5R01AI128344-05

an Evergrande COVID-19 Response Fund Award from the Massachusetts Consortium on Pathogen Readiness (“MassCPR”)
05/01/2020 - 04/30/2022 (PI)
Harvard Medical School China Evergrande Gr

Competitive Revision to Existing NIH Grants NIGMS - Predictive Models for the Spread of…
04/01/2020 - 03/31/2022 (PI)
Trustees of Boston University NIH-NIGMS

The impact of alcohol consumption on TB treatment outcomes
04/08/2016 - 03/31/2022 (PI)
NIH-NIAID
5R01AI119037-04

URBAN ARCH (3/5) Uganda Cohort- TB prevention therapy for HIV-infected alcohol drinkers in Uganda…
09/22/2016 - 08/31/2021 (PI)
The Regents of the University of California NIH-NIAAA

Biomarkers and Mechanisms of Paucibacillary and Latent Tuberculosis
11/01/2018 - 07/31/2021 (PI)
Rutgers The State University of New Jersey NIH-NIAID
5U19AI111276-08

Showing 10 of 16 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)	5R01AI147316-05
2022	Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)	5R01AI147316-04
2022	SWG1: HIV/TB Scientific Working Group	5P30AI042853-24-7401
2021	Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)	5R01AI147316-03
2021	SWG1: HIV/TB Scientific Working Group	5P30AI042853-23-7401	905
2020	Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)	5R01AI147316-02
2020	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-05	3
2020	SWG1: HIV/TB Scientific Working Group	5P30AI042853-22-7401	905
2019	Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL)	1R01AI147316-01
2019	The impact of alcohol consumption on TB treatment outcomes	5R01AI119037-04	3

Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Acuña-Villaorduña C, Jacobson KR, Horsburgh CR, Canning M, Sinha P. Initial experience with BPaL-based regimens to treat multidrug-resistant TB. Int J Tuberc Lung Dis. 2023 Aug 01; 27(8):649-650.View Related Profiles.

Horsburgh, C.
Jacobson, Karen

PMID: 37491751; PMCID: PMC10365559; DOI: 10.5588/ijtld.23.0185;

Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR, Salgame P, Alland D, Barry CE, Flynn JL, Ellner JJ, Wilkinson RJ. High resolution imaging and five-year tuberculosis contact outcomes. medRxiv. 2023 Jul 03.View Related Profiles.

Horsburgh, C.
Jacobson, Karen

PMID: 37461515; PMCID: PMC10350144; DOI: 10.1101/2023.07.03.23292111;

Myers B, Carney T, Rooney J, Malatesta S, Ragan EJ, White LF, Natcheva H, Bouton TC, Weber SE, Farhat M, McIlleron H, Theron D, Parry CDH, Horsburgh CR, Warren RM, Jacobson KR. Smoked drug use in patients with TB is associated with higher bacterial burden. Int J Tuberc Lung Dis. 2023 Jun 01; 27(6):444-450.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
Bouton, Tara

PMID: 37231597; PMCID: PMC10407961; DOI: 10.5588/ijtld.22.0650;

Hahn JA, Ngabirano C, Fatch R, Emenyonu NI, Cheng DM, Adong J, Tumwegamire A, Terrault NA, Linas BP, Jacobson KR, Muyindike WR. Safety and tolerability of isoniazid preventive therapy for tuberculosis for persons with HIV with and without alcohol use. AIDS. 2023 Aug 01; 37(10):1535-1543.View Related Profiles.

Linas, Benjamin
Cheng, Debbie
Jacobson, Karen

PMID: 37260251; PMCID: PMC10355800; DOI: 10.1097/QAD.0000000000003613;

Adeoye B, Nakiyingi L, Moreau Y, Nankya E, Olson AJ, Zhang M, Jacobson KR, Gupta A, Manabe YC, Hosseinipour MC, Kumwenda J, Sagar M. Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses. iScience. 2023 May 19; 26(5):106631.View Related Profiles.

Olson, Alex
Jacobson, Karen
Sagar, Manish

PMID: 37168567; PMCID: PMC10165194; DOI: 10.1016/j.isci.2023.106631;

Sinha P, Jacobson KR, Horsburgh CR, Acuña-Villaorduña C. At Long Last: Short, All-Oral Regimens for Multidrug-Resistant Tuberculosis in the United States. Open Forum Infect Dis. 2023 Apr; 10(4):ofad177.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
Sinha, Pranay

PMID: 37125228; PMCID: PMC10135426; DOI: 10.1093/ofid/ofad177;

Fofana AM, Moultrie H, Scott L, Jacobson KR, Shapiro AN, Dor G, Crankshaw B, Silva PD, Jenkins HE, Bor J, Stevens WS. Cross-municipality migration and spread of tuberculosis in South Africa. Sci Rep. 2023 Feb 15; 13(1):2674.View Related Profiles.

Jenkins, Helen
Bor, Jacob
Jacobson, Karen

PMID: 36792792; PMCID: PMC9930008; DOI: 10.1038/s41598-023-29804-5;

Bouton TC, Atarere J, Turcinovic J, Seitz S, Sher-Jan C, Gilbert M, White L, Zhou Z, Hossain MM, Overbeck V, Doucette-Stamm L, Platt J, Landsberg HE, Hamer DH, Klapperich C, Jacobson KR, Connor JH. Viral Dynamics of Omicron and Delta Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants With Implications for Timing of Release from Isolation: A Longitudinal Cohort Study. Clin Infect Dis. 2023 Feb 08; 76(3):e227-e233.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Jacobson, Karen
White, Laura
Seitz, Scott
Bouton, Tara

PMID: 35737948; PMCID: PMC9278204; DOI: 10.1093/cid/ciac510;

Petros BA, Turcinovic J, Welch NL, White LF, Kolaczyk ED, Bauer MR, Cleary M, Dobbins ST, Doucette-Stamm L, Gore M, Nair P, Nguyen TG, Rose S, Taylor BP, Tsang D, Wendlandt E, Hope M, Platt JT, Jacobson KR, Bouton T, Yune S, Auclair JR, Landaverde L, Klapperich CM, Hamer DH, Hanage WP, MacInnis BL, Sabeti PC, Connor JH, Springer M. Early Introduction and Rise of the Omicron Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant in Highly Vaccinated University Populations. Clin Infect Dis. 2023 Feb 08; 76(3):e400-e408.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 35616119; PMCID: PMC9213864; DOI: 10.1093/cid/ciac413;

Muyindike WR, Fatch R, Cheng DM, Emenyonu NI, Forman L, Ngabirano C, Adong J, Linas B, Jacobson KR, Hahn JA. Unhealthy Alcohol Use Is Associated With Suboptimal Adherence to Isoniazid Preventive Therapy in Persons With HIV in Southwestern Uganda. J Acquir Immune Defic Syndr. 2022 Dec 15; 91(5):460-468.View Related Profiles.

Linas, Benjamin
Cheng, Debbie
Jacobson, Karen

PMID: 36044285; PMCID: PMC9649866; DOI: 10.1097/QAI.0000000000003082;

Showing 10 of 67 results. Show More

Malatesta S, Weir IR, Weber SE, Bouton TC, Carney T, Theron D, Myers B, Horsburgh CR, Warren RM, Jacobson KR, White LF. Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation. BMC Med Res Methodol. 2022 Nov 19; 22(1):297.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 36402979; PMCID: PMC9675206; DOI: 10.1186/s12874-022-01782-8;

Turcinovic J, Schaeffer B, Taylor BP, Bouton TC, Odom-Mabey AR, Weber SE, Lodi S, Ragan EJ, Connor JH, Jacobson KR, Hanage WP. Understanding Early Pandemic Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in a Medical Center by Incorporating Public Sequencing Databases to Mitigate Bias. J Infect Dis. 2022 Nov 11; 226(10):1704-1711.View Related Profiles.

Connor, John
Jacobson, Karen
Lodi, Sara
Bouton, Tara

PMID: 35993116; PMCID: PMC9452097; DOI: 10.1093/infdis/jiac348;

Forman LS, Lodi S, Fatch R, Emenyonu NI, Adong J, Ngabirano C, Jacobson KR, Gerona R, Reckers AR, Gandhi M, Muyindike WR, Hahn JA. Agreement Between Measures of Adherence to Isoniazid Preventive Therapy Among People With HIV in Uganda. Open Forum Infect Dis. 2022 Oct; 9(10):ofac516.View Related Profiles.

Jacobson, Karen
Lodi, Sara

PMID: 36320196; PMCID: PMC9605696; DOI: 10.1093/ofid/ofac516;

Barocas JA, Savinkina A, Lodi S, Epstein RL, Bouton TC, Sperring H, Hsu HE, Jacobson KR, Schechter-Perkins EM, Linas BP, White LF. Projected Long-Term Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hepatitis C Outcomes in the United States: A Modeling Study. Clin Infect Dis. 2022 Aug 24; 75(1):e1112-e1119.View Related Profiles.

Linas, Benjamin
Schechter-Perkins, Elissa
Hsu, Heather
Barocas, Joshua
Jacobson, Karen
White, Laura
Epstein, Rachel
Lodi, Sara
Bouton, Tara

PMID: 34499124; PMCID: PMC8522427; DOI: 10.1093/cid/ciab779;

Sy KTL, Leavitt SV, de Vos M, Dolby T, Bor J, Horsburgh CR, Warren RM, Streicher EM, Jenkins HE, Jacobson KR. Spatial heterogeneity of extensively drug resistant-tuberculosis in Western Cape Province, South Africa. Sci Rep. 2022 Jun 27; 12(1):10844.View Related Profiles.

Horsburgh, C.
Jenkins, Helen
Bor, Jacob
Jacobson, Karen

PMID: 35760977; PMCID: PMC9237070; DOI: 10.1038/s41598-022-14581-4;

Bouton TC, Atarere J, Turcinovic J, Seitz S, Sher-Jan C, Gilbert M, White L, Zhou Z, Hossain MM, Overbeck V, Doucette-Stamm L, Platt J, Landsberg HE, Hamer DH, Klapperich C, Jacobson KR, Connor JH. Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort study. medRxiv. 2022 Apr 05.View Related Profiles.

Klapperich, Catherine
Hamer, Davidson
Connor, John
Platt, Judy
Jacobson, Karen
White, Laura
Seitz, Scott
Bouton, Tara

PMID: 35411341; PMCID: PMC8996632; DOI: 10.1101/2022.04.04.22273429;

Wigger GW, Bouton TC, Jacobson KR, Auld SC, Yeligar SM, Staitieh BS. The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms. Front Immunol. 2022; 13:864817.View Related Profiles.

Jacobson, Karen
Bouton, Tara

PMID: 35432348; PMCID: PMC9009367; DOI: 10.3389/fimmu.2022.864817;

Runels T, Ragan EJ, Ventura AS, Winter MR, White LF, Horsburgh CR, Samet JH, Saitz R, Jacobson KR. Testing and treatment for latent tuberculosis infection in people living with HIV and substance dependence: a prospective cohort study. BMJ Open. 2022 03 10; 12(3):e058751.View Related Profiles.

Horsburgh, C.
Samet, Jeffrey
Jacobson, Karen
White, Laura
Saitz, Richard

PMID: 35273063; PMCID: PMC8915380; DOI: 10.1136/bmjopen-2021-058751;

Carney T, Rooney JA, Niemand N, Myers B, Theron D, Wood R, White LF, Meade CS, Chegou NN, Ragan E, Walzl G, Horsburgh R, Warren RM, Jacobson KR. Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling. PLoS One. 2022; 17(2):e0262440.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura

PMID: 35167586; PMCID: PMC8846525; DOI: 10.1371/journal.pone.0262440;

Ragan EJ, McCallum C, Marathe J, Cole M, Hofman M, Henderson AJ, Flack T, Miller NS, Burks EJ, Zhao GQ, Denis R, Lin NH, Jacobson KR, Andry CD, Pelton SI, Duffy ER, Bhadelia N. Pandemic Response Requires Research Samples: A U.S. Safety-Net Hospital's Experience and Call for National Action. Ann Intern Med. 2021 12; 174(12):1727-1732.View Related Profiles.

Henderson, Andrew
Duffy, Elizabeth
Burks, Eric
Marathe, Jai
Jacobson, Karen
Bhadelia, Nahid
Miller, Nancy
Lin, Nina
Pelton, Stephen

PMID: 34724402; DOI: 10.7326/M21-2857;

Bouton TC, Lodi S, Turcinovic J, Schaeffer B, Weber SE, Quinn E, Korn C, Steiner J, Schechter-Perkins EM, Duffy E, Ragan EJ, Taylor BP, Miller N, Davidoff R, Hanage WP, Connor J, Pierre C, Jacobson KR. Coronavirus Disease 2019 Vaccine Impact on Rates of Severe Acute Respiratory Syndrome Coronavirus 2 Cases and Postvaccination Strain Sequences Among Health Care Workers at an Urban Academic Medical Center: A Prospective Cohort Study. Open Forum Infect Dis. 2021 Oct; 8(10):ofab465.View Related Profiles.

Pierre, Cassandra
Schechter-Perkins, Elissa
Duffy, Elizabeth
Connor, John
Jacobson, Karen
Miller, Nancy
Davidoff, Ravin
Lodi, Sara
Bouton, Tara

PMID: 34646910; PMCID: PMC8500299; DOI: 10.1093/ofid/ofab465;

Berhanu RH, Jacobson KR. Tuberculosis Preventive Therapy for People With HIV Infection in High Tuberculosis Burden Settings: How Much Is Enough? Ann Intern Med. 2021 10; 174(10):1462-1463.View Related Profiles.

Jacobson, Karen
Berhanu, Rebecca

PMID: 34424729

Bouton TC, Jacobson KR. Symptom Screens Are Not Sufficient: The Fight Against Tuberculosis Needs Better Weapons. Clin Infect Dis. 2021 07 01; 73(1):121-123.View Related Profiles.

Jacobson, Karen
Bouton, Tara

PMID: 32296819; PMCID: PMC8246807; DOI: 10.1093/cid/ciaa440;

Ragan EJ, Gill CJ, Banos M, Bouton TC, Rooney J, Horsburgh CR, Warren RM, Myers B, Jacobson KR. Directly Observed Therapy to Measure Adherence to Tuberculosis Medication in Observational Research: Protocol for a Prospective Cohort Study. JMIR Res Protoc. 2021 Jun 16; 10(6):e24510.View Related Profiles.

Horsburgh, C.
Gill, Christopher
Jacobson, Karen
Bouton, Tara

PMID: 34132642; PMCID: PMC8277341; DOI: 10.2196/24510;

Freiman JM, Fatch R, Cheng D, Emenyonu N, Ngabirano C, Geadas C, Adong J, Muyindike WR, Linas BP, Jacobson KR, Hahn JA. Prevalence of elevated liver transaminases and their relationship with alcohol use in people living with HIV on anti-retroviral therapy in Uganda. PLoS One. 2021; 16(6):e0250368.View Related Profiles.

Linas, Benjamin
Cheng, Debbie
Jacobson, Karen

PMID: 34061870; PMCID: PMC8168875; DOI: 10.1371/journal.pone.0250368;

Myers B, Carney T, Rooney J, Malatesta S, White LF, Parry CDH, Bouton TC, Ragan EJ, Horsburgh CR, Warren RM, Jacobson KR. Alcohol and Tobacco Use in a Tuberculosis Treatment Cohort during South Africa's COVID-19 Sales Bans: A Case Series. Int J Environ Res Public Health. 2021 05 19; 18(10).View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 34069737; PMCID: PMC8161406; DOI: 10.3390/ijerph18105449;

Hahn JA, Murnane PM, Vittinghoff E, Muyindike WR, Emenyonu NI, Fatch R, Chamie G, Haberer JE, Francis JM, Kapiga S, Jacobson K, Myers B, Couture MC, DiClemente RJ, Brown JL, So-Armah K, Sulkowski M, Marcus GM, Woolf-King S, Cook RL, Richards VL, Molina P, Ferguson T, Welsh D, Piano MR, Phillips SA, Stewart S, Afshar M, Page K, McGinnis K, Fiellin DA, Justice AC, Bryant K, Saitz R. Factors associated with phosphatidylethanol (PEth) sensitivity for detecting unhealthy alcohol use: An individual patient data meta-analysis. Alcohol Clin Exp Res. 2021 06; 45(6):1166-1187.View Related Profiles.

So-Armah, Kaku
Jacobson, Karen
Saitz, Richard

PMID: 33837975; PMCID: PMC8254773; DOI: 10.1111/acer.14611;

Kataria Y, Cole M, Duffy E, de la Cena K, Schechter-Perkins EM, Bouton TC, Werler MM, Pierre C, Ragan EJ, Weber SE, Jacobson KR, Andry C. Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts. Sci Rep. 2021 05 06; 11(1):9694.View Related Profiles.

Pierre, Cassandra
Andry, Christopher
Schechter-Perkins, Elissa
Duffy, Elizabeth
Jacobson, Karen
Werler, Martha
Bouton, Tara
Kataria, Yachana

PMID: 33958668; PMCID: PMC8102593; DOI: 10.1038/s41598-021-89107-5;

Bouton TC, Lodi S, Turcinovic J, Weber SE, Quinn E, Korn C, Steiner J, Schechter-Perkins EM, Duffy E, Ragan EJ, Taylor BP, Schaeffer B, Miller N, Davidoff R, Hanage WP, Connor J, Pierre C, Jacobson KR. COVID-19 vaccine impact on rates of SARS-CoV-2 cases and post vaccination strain sequences among healthcare workers at an urban academic medical center: a prospective cohort study. medRxiv. 2021 Mar 31.View Related Profiles.

Pierre, Cassandra
Schechter-Perkins, Elissa
Connor, John
Jacobson, Karen
Miller, Nancy
Lodi, Sara
Bouton, Tara

PMID: 33821283; PMCID: PMC8020984; DOI: 10.1101/2021.03.30.21254655;

Barocas JA, Jacobson KR, Hamer DH. Addressing the COVID-19 Pandemic Among Persons Experiencing Homelessness: Steps to Protect a Vulnerable Population. J Gen Intern Med. 2021 05; 36(5):1416-1417.View Related Profiles.

Hamer, Davidson
Barocas, Joshua
Jacobson, Karen

PMID: 33532960; PMCID: PMC7852479; DOI: 10.1007/s11606-020-06434-5;

Leavitt SV, Jacobson KR, Ragan EJ, Bor J, Hughes J, Bouton TC, Dolby T, Warren RM, Jenkins HE. Decentralized Care for Rifampin-Resistant Tuberculosis, Western Cape, South Africa. Emerg Infect Dis. 2021; 27(3):728-739.View Related Profiles.

Jenkins, Helen
Bor, Jacob
Jacobson, Karen
Bouton, Tara

PMID: 33622466; PMCID: PMC7920662; DOI: 10.3201/eid2703.203204;

Kan CK, Ragan EJ, Sarkar S, Knudsen S, Forsyth M, Muthuraj M, Vinod K, Jenkins HE, Horsburgh CR, Salgame P, Roy G, Ellner JJ, Jacobson KR, Sahu S, Hochberg NS. Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India. PLoS One. 2020; 15(12):e0240595.View Related Profiles.

Horsburgh, C.
Jenkins, Helen
Ellner, Jerrold
Jacobson, Karen
Hochberg, Natasha

PMID: 33332367; PMCID: PMC7746146; DOI: 10.1371/journal.pone.0240595;

He X, Eddy JJ, Jacobson KR, Henderson AJ, Agosto LM. Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection. J Infect Dis. 2020 10 01; 222(9):1550-1560.View Related Profiles.

Henderson, Andrew
Jacobson, Karen
He, Xianbao

PMID: 32417884; PMCID: PMC7529013; DOI: 10.1093/infdis/jiaa257;

Eddy JJ, Gadani KM, Tibbs A, Bernardo J, Cochran J, White LF, Horsburgh CR, Jacobson KR. Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009-2018. Open Forum Infect Dis. 2020 Aug; 7(8):ofaa300.View Related Profiles.

Horsburgh, C.
Bernardo, John
Jacobson, Karen
White, Laura

PMID: 32855987; PMCID: PMC7444736; DOI: 10.1093/ofid/ofaa300;

Hsu HE, Ashe EM, Silverstein M, Hofman M, Lange SJ, Razzaghi H, Mishuris RG, Davidoff R, Parker EM, Penman-Aguilar A, Clarke KEN, Goldman A, James TL, Jacobson K, Lasser KE, Xuan Z, Peacock G, Dowling NF, Goodman AB. Race/Ethnicity, Underlying Medical Conditions, Homelessness, and Hospitalization Status of Adult Patients with COVID-19 at an Urban Safety-Net Medical Center - Boston, Massachusetts, 2020. MMWR Morb Mortal Wkly Rep. 2020 Jul 10; 69(27):864-869.View Related Profiles.

Goldman, Anna
Hsu, Heather
Lasser, Karen
Jacobson, Karen
Silverstein, Michael
Davidoff, Ravin
Mishuris, Rebecca
James, Thea
Xuan, Ziming

PMID: 32644981; PMCID: PMC7727597; DOI: 10.15585/mmwr.mm6927a3;

Muyindike WR, Fatch R, Cheng DM, Emenyonu NI, Ngabirano C, Adong J, Linas BP, Jacobson KR, Hahn JA. Tuberculin skin test positivity among HIV-infected alcohol drinkers on antiretrovirals in south-western Uganda. PLoS One. 2020; 15(7):e0235261.View Related Profiles.

Linas, Benjamin
Cheng, Debbie
Jacobson, Karen

PMID: 32614873; PMCID: PMC7332058; DOI: 10.1371/journal.pone.0235261;

Ragan EJ, Kleinman MB, Sweigart B, Gnatienko N, Parry CD, Horsburgh CR, LaValley MP, Myers B, Jacobson KR. The impact of alcohol use on tuberculosis treatment outcomes: a systematic review and meta-analysis. Int J Tuberc Lung Dis. 2020 01 01; 24(1):73-82.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
LaValley, Michael

PMID: 32005309; PMCID: PMC7491444; DOI: 10.5588/ijtld.19.0080;

Bouton TC, de Vos M, Ragan EJ, White LF, Van Zyl L, Theron D, Horsburgh CR, Warren RM, Jacobson KR. Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis. PLoS One. 2019; 14(10):e0223308.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 31622366; PMCID: PMC6797261; DOI: 10.1371/journal.pone.0223308;

Bulabula ANH, Nelson JA, Musafiri EM, Machekano R, Sam-Agudu NA, Diacon AH, Shah M, Creswell J, Theron G, Warren RM, Jacobson KR, Chirambiza JP, Kalumuna D, Bisimwa BC, Katoto PDMC, Kaswa MK, Birembano FM, Kitete L, Grobusch MP, Kashongwe ZM, Nachega JB. Prevalence, Predictors, and Successful Treatment Outcomes of Xpert MTB/RIF-identified Rifampicin-resistant Tuberculosis in Post-conflict Eastern Democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study. Clin Infect Dis. 2019 09 27; 69(8):1278-1287. PMID: 30759187; PMCID: PMC6763636; DOI: 10.1093/cid/ciy1105;

van der Heijden YF, Hughes J, Dowdy DW, Streicher E, Chihota V, Jacobson KR, Warren R, Theron G. Overcoming limitations of tuberculosis information systems: researcher and clinician perspectives. Public Health Action. 2019 Sep 21; 9(3):120-127. PMID: 31803584; PMCID: PMC6827492; DOI: 10.5588/pha.19.0014;

Bouton TC, Forson A, Kudzawu S, Zigah F, Jenkins H, Bamfo TD, Carter J, Jacobson K, Kwara A. High mortality during tuberculosis retreatment at a Ghanaian tertiary center: a retrospective cohort study. Pan Afr Med J. 2019; 33:111.View Related Profiles.

Jenkins, Helen
Jacobson, Karen
Bouton, Tara

PMID: 31489089; PMCID: PMC6711700; DOI: 10.11604/pamj.2019.33.111.18574;

Berhanu RH, Schnippel K, Kularatne R, Firnhaber C, Jacobson KR, Horsburgh CR, Lippincott CK. Discordant rifampicin susceptibility results are associated with Xpert® MTB/RIF probe B and probe binding delay. Int J Tuberc Lung Dis. 2019 03 01; 23(3):358-362.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
Berhanu, Rebecca

PMID: 30940300; PMCID: PMC6495054; DOI: 10.5588/ijtld.16.0837;

Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M. Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans. J Acquir Immune Defic Syndr. 2018 11 01; 79(3):407-411.View Related Profiles.

Olson, Alex
Ellner, Jerrold
Jacobson, Karen
Sagar, Manish
Lin, Nina

PMID: 30063648; PMCID: PMC6506856; DOI: 10.1097/QAI.0000000000001823;

Myers B, Bouton TC, Ragan EJ, White LF, McIlleron H, Theron D, Parry CDH, Horsburgh CR, Warren RM, Jacobson KR. Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol. BMC Infect Dis. 2018 Sep 29; 18(1):488.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
White, Laura
Bouton, Tara

PMID: 30268101; PMCID: PMC6162918; DOI: 10.1186/s12879-018-3396-y;

McIntosh AI, Jenkins HE, White LF, Barnard M, Thomson DR, Dolby T, Simpson J, Streicher EM, Kleinman MB, Ragan EJ, van Helden PD, Murray MB, Warren RM, Jacobson KR. Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis. PLoS Med. 2018 08; 15(8):e1002638.View Related Profiles.

Jenkins, Helen
Jacobson, Karen
White, Laura

PMID: 30130377; PMCID: PMC6103505; DOI: 10.1371/journal.pmed.1002638;

Berhanu RH, Schnippel K, Kularatne R, Firnhaber C, Jacobson KR, Horsburgh CR, Lippincott CK. Can patients afford the cost of treatment for multidrug-resistant tuberculosis in Ethiopia? Int J Tuberc Lung Dis. 2018 08 01; 22(8):358-362.View Related Profiles.

Horsburgh, C.
Jacobson, Karen
Berhanu, Rebecca

PMID: 29991400; PMCID: PMC6421943; DOI: 10.5588/ijtld.17.0837;

Geadas C, Acuna-Villaorduna C, Mercier G, Kleinman MB, Horsburgh CR, Ellner JJ, Jacobson KR. FDG-PET/CT activity leads to the diagnosis of unsuspected TB: a retrospective study. BMC Res Notes. 2018 Jul 13; 11(1):464.View Related Profiles.

Horsburgh, C.
Acuna-Villaorduna, Carlos
Mercier, Gustavo
Ellner, Jerrold
Jacobson, Karen

PMID: 30001743; PMCID: PMC6044021; DOI: 10.1186/s13104-018-3564-6;

Fregonese F, Ahuja SD, Akkerman OW, Arakaki-Sanchez D, Ayakaka I, Baghaei P, Bang D, Bastos M, Benedetti A, Bonnet M, Cattamanchi A, Cegielski P, Chien JY, Cox H, Dedicoat M, Erkens C, Escalante P, Falzon D, Garcia-Prats AJ, Gegia M, Gillespie SH, Glynn JR, Goldberg S, Griffith D, Jacobson KR, Johnston JC, Jones-López EC, Khan A, Koh WJ, Kritski A, Lan ZY, Lee JH, Li PZ, Maciel EL, Galliez RM, Merle CSC, Munang M, Narendran G, Nguyen VN, Nunn A, Ohkado A, Park JS, Phillips PPJ, Ponnuraja C, Reves R, Romanowski K, Seung K, Schaaf HS, Skrahina A, Soolingen DV, Tabarsi P, Trajman A, Trieu L, Banurekha VV, Viiklepp P, Wang JY, Yoshiyama T, Menzies D. Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2018 04; 6(4):265-275. PMID: 29595509; PMCID: PMC9017096; DOI: 10.1016/S2213-2600(18)30078-X;

Freiman JM, Jacobson KR, Muyindike WR, Horsburgh CR, Ellner JJ, Hahn JA, Linas BP. Isoniazid Preventive Therapy for People With HIV Who Are Heavy Alcohol Drinkers in High TB-/HIV-Burden Countries: A Risk-Benefit Analysis. J Acquir Immune Defic Syndr. 2018 04 01; 77(4):405-412.View Related Profiles.

Linas, Benjamin
Horsburgh, C.
Ellner, Jerrold
Freiman, Julie
Jacobson, Karen

PMID: 29239900; PMCID: PMC5825241; DOI: 10.1097/QAI.0000000000001610;

Brooks-Pollock E, Jacobson KR. Rethinking tuberculosis control by targeting previously treated individuals. Lancet Glob Health. 2018 04; 6(4):e361-e362. PMID: 29472017

Farhat MR, Jacobson KR, Franke MF, Kaur D, Murray M, Mitnick CD. Fluoroquinolone Resistance Mutation Detection Is Equivalent to Culture-Based Drug Sensitivity Testing for Predicting Multidrug-Resistant Tuberculosis Treatment Outcome: A Retrospective Cohort Study. Clin Infect Dis. 2017 Oct 15; 65(8):1364-1370. PMID: 29017248; PMCID: PMC5850426; DOI: 10.1093/cid/cix556;

Jacobson KR, Barnard M, Kleinman MB, Streicher EM, Ragan EJ, White LF, Shapira O, Dolby T, Simpson J, Scott L, Stevens W, van Helden PD, Van Rie A, Warren RM. Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study. Clin Infect Dis. 2017 Jun 01; 64(11):1502-1508.View Related Profiles.

Jacobson, Karen
White, Laura

PMID: 28199520; PMCID: PMC5434334; DOI: 10.1093/cid/cix128;

Jacobson KR. Tuberculosis. Ann Intern Med. 2017 Feb 07; 166(3):ITC17-ITC32. PMID: 28166561; DOI: 10.7326/AITC201702070;

Farhat MR, Sultana R, Iartchouk O, Bozeman S, Galagan J, Sisk P, Stolte C, Nebenzahl-Guimaraes H, Jacobson K, Sloutsky A, Kaur D, Posey J, Kreiswirth BN, Kurepina N, Rigouts L, Streicher EM, Victor TC, Warren RM, van Soolingen D, Murray M. Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value. Am J Respir Crit Care Med. 2016 Sep 01; 194(5):621-30.View Related Profiles.

Galagan, James
Jacobson, Karen

PMID: 26910495; PMCID: PMC5027209; DOI: 10.1164/rccm.201510-2091OC;

Farhat MR, Jacobson KR, Franke MF, Kaur D, Sloutsky A, Mitnick CD, Murray M. Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis. J Clin Microbiol. 2016 Mar; 54(3):727-33. PMID: 26763957; PMCID: PMC4767988; DOI: 10.1128/JCM.02775-15;

Jacobson KR, Sabin LL. Scaling up multidrug-resistant tuberculosis care in China. Lancet Glob Health. 2015 Apr; 3(4):e183-4.View Related Profiles.

Jacobson, Karen
Sabin, Lora

PMID: 25794667; PMCID: PMC4492310; DOI: 10.1016/S2214-109X(15)70093-8;

Farhat MR, Mitnick CD, Franke MF, Kaur D, Sloutsky A, Murray M, Jacobson KR. Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment. Int J Tuberc Lung Dis. 2015 Mar; 19(3):339-41. PMID: 25686144; PMCID: PMC4486051; DOI: 10.5588/ijtld.14.0814;

Kendall EA, Theron D, Franke MF, van Helden P, Victor TC, Murray MB, Warren RM, Jacobson KR. Alcohol, hospital discharge, and socioeconomic risk factors for default from multidrug resistant tuberculosis treatment in rural South Africa: a retrospective cohort study. PLoS One. 2013; 8(12):e83480. PMID: 24349518; PMCID: PMC3862731; DOI: 10.1371/journal.pone.0083480;

Nebenzahl-Guimaraes H, Jacobson KR, Farhat MR, Murray MB. Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis. J Antimicrob Chemother. 2014 Feb; 69(2):331-42. PMID: 24055765; PMCID: PMC3886931; DOI: 10.1093/jac/dkt358;

Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, Kaur D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, Johnston JC, Rodrigues M, Tang PK, Kato-Maeda M, Borowsky ML, Muddukrishna B, Kreiswirth BN, Kurepina N, Galagan J, Gagneux S, Birren B, Rubin EJ, Lander ES, Sabeti PC, Murray M. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nat Genet. 2013 Oct; 45(10):1183-9.View Related Profiles.

Galagan, James
Jacobson, Karen

PMID: 23995135; PMCID: PMC3887553; DOI: 10.1038/ng.2747;

Jacobson KR, Theron D, Kendall EA, Franke MF, Barnard M, van Helden PD, Victor TC, Streicher EM, Murray MB, Warren RM. Implementation of genotype MTBDRplus reduces time to multidrug-resistant tuberculosis therapy initiation in South Africa. Clin Infect Dis. 2013 Feb; 56(4):503-8. PMID: 23090928; PMCID: PMC3552527; DOI: 10.1093/cid/cis920;

Mukinda FK, Theron D, van der Spuy GD, Jacobson KR, Roscher M, Streicher EM, Musekiwa A, Coetzee GJ, Victor TC, Marais BJ, Nachega JB, Warren RM, Schaaf HS. Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa. Int J Tuberc Lung Dis. 2012 Feb; 16(2):196-202. PMID: 22236920; PMCID: PMC3712259; DOI: 10.5588/ijtld.11.0116;

Jacobson KR, Theron D, Victor TC, Streicher EM, Warren RM, Murray MB. Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa. Clin Infect Dis. 2011 Aug; 53(4):369-72. PMID: 21810750; PMCID: PMC3202325; DOI: 10.1093/cid/cir406;

Jacobson KR, Tierney DB, Jeon CY, Mitnick CD, Murray MB. Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis. Clin Infect Dis. 2010 Jul 1; 51(1):6-14. PMID: 20504231; PMCID: PMC4013786; DOI: 10.1086/653115;

Jacobson KR, Murray K, Zellos A, Schwarz KB. An analysis of published trials of interferon monotherapy in children with chronic hepatitis C. J Pediatr Gastroenterol Nutr. 2002 Jan; 34(1):52-8. PMID: 11753165

Altemus M, Greenberg BD, Keuler D, Jacobson KR, Murphy DL. Open trial of flutamide for treatment of obsessive-compulsive disorder. J Clin Psychiatry. 1999 Jul; 60(7):442-5. PMID: 10453797

Altemus M, Jacobson KR, Debellis M, Kling M, Pigott T, Murphy DL, Gold PW. Normal CSF oxytocin and NPY levels in OCD. Biol Psychiatry. 1999 Apr 1; 45(7):931-3. PMID: 10202583

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 15 distinct years, with a maximum of 12 publications in 2021

Bar chart showing 67 publications over 15 distinct years, with a maximum of 12 publications in 2021

Year	Publications
1999	2
2002	1
2010	1
2011	1
2012	2
2013	3
2015	2
2016	2
2017	3
2018	8
2019	5
2020	6
2021	12
2022	10
2023	9

Media Mentions

Best of The Brink 2022: BU’s Most-Read Science and Research Stories

BU Today 12/13/2022

The One COVID Taboo Left

Slate 7/20/2022

Still testing positive after day 10? How to decide when to end your COVID isolation

NPR 6/30/2022

Dr. Karen Jacobson from Boston University School of Medicine discusses a new study into how long vaccinated people with COVID remain infectious

Boston 25 News 6/27/2022

A Bellwether for COVID-19

Harvard Medical School 6/8/2022

Is Five Days of COVID Isolation Enough? New BU Study Has Some Answers

BU Today 4/12/2022

BU Scientists Are Prepared to Detect Omicron—and Other Variants

BU Today 12/9/2021

Scientists race to define Omicron threat, worried about ‘surge upon a surge’

The Harvard Gazette 12/9/2021

Experts: Current tests detect Omicron variant, but transmissibility a concern

UPI 12/7/2021

Projected Long-Term Impact of the COVID-19 Pandemic on Outcomes Associated With Hepatitis C Virus

Infection Disease Advisor 10/7/2021

Councilors, medical experts push for more in-person learning at Newton schools

Wicked Local 1/11/2021

COVID-19 Biorepository Builds Opportunity for Care Equity

HealthCity 12/17/2020

CDC Director Appointee Rochelle Walensky “Won’t Be Susceptible to Political Pressure”

The Brink 12/8/2020

The Superspreading Presidency of Donald Trump

Wired 10/7/2020

New method may allow real-time surveillance of drug-resistant TB

The Daily Star 8/19/2018

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

alcohol
drug resistant tuberculosis
global health
spatial mapping
tuberculosis

Available to Mentor as: (Review Mentor Role Definitions):