Dr. Fetterman is a basic and translational scientist studying the intersections of mitochondrial physiology, mitochondrial genetic epidemiology, and cardiovascular disease. Her work focuses on the contribution of mitochondrial genetic variation and abnormalities to cardiovascular disease in the presence of risk factors, including tobacco product use and diabetes.
Using bioinformatics methods, Dr. Fetterman discovered that several select mitochondrial genetic variants are associated with non-invasive measures of vascular function within the Framingham Heart Study (FHS). Additionally, she has applied similar methodology to select mitochondrial single variant data within Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) to determine the associations of select mitochondrial genetic variants with cardiometabolic measures in collaboration with members of the mitochondrial genetics working group. Recently, Dr. Fetterman was awarded the competitive Trans-Omics Precision Medicine (TOPMed) Analytical Support Award for early career investigators to perform comprehensive bioinformatic annotation of the mitochondrial genetic variants within the TOPMed cohorts.
Dr. Fetterman also conducts research on the impact of new and emerging tobacco products on the vasculature, particularly studies designed to inform tobacco product regulation. Some of her recent work demonstrated that tobacco product flavoring additives induce vascular endothelial dysfunction, an early indicator of cardiovascular injury. She serves as an Associate Director of Education and Training within American Heart Association Tobacco Regulation and Addiction Center. Additionally, she is the Director for the Boston University Tobacco Regulatory Science Affinity Research Collaborative, which is designed to bring together multi-disciplinary teams of scientists within Boston University to increase our understanding of tobacco product use patterns and the impact of new and emerging tobacco products on human health and disease.
Diversity, Equity, Inclusion and Accessibility
Within our lab, we strive to create a respectful and inclusive environment where all voices are encouraged, regardless of rank, seniority, position, or background. We each bring different experiences and perspectives that allow us to grow and develop new areas of research together. Creativity thrives in an open, positive environment where everyone’s viewpoint and input is valued and all member contributions are welcome and appreciated. We expect members of our lab to contribute to the growth and advancement of the entire group by providing timely, behaviorally-based, constructive feedback to team members and by sharing resources, protocols, and credit. Members of our team are expected to lift each other up as they rise, not tear each other down.
We approach our science with a diversity, equity, inclusive, and accessibility focus. We include both sexes and individuals across different ancestries and races in our research studies.
I am deeply committed to the mentorship and advancement of individuals from under-represented groups in science and medicine. I have mentored 25 undergraduates, PhD candidates, medical students, residents, and fellows, of whom, 22 are from groups under-represented in science. As an emerging leader, I believe it is the responsibility of each of us to mentor and advocate for change to create a more diverse, equitable, inclusive, and accessible field.
Framingham Heart Study
Whitaker Cardiovascular Institute
Evans Center for Interdisciplinary Biomedical Research
Relations of Mitochondrial Genetic Variation and Function with Atrial Fibrillation
04/01/2019 - 03/31/2024 (PI)NIH/National Heart, Lung, and Blood Institute5K01HL143142-04
Strategies to Understand Pathobiology, Predictors & Pharmacotherapy to Reduce Adverse CV Outcomes in T2DM (SUPER-CVDM)
01/01/2020 - 12/31/2023 (Subcontract PI)The Brigham and Women's Hospital, Inc. American Heart Assoc
E-cigarette-Induced Endothelial Dysfunction in Human Participants
01/01/2017 - 12/31/2018 (PI)American Heart Association
AHA Tobacco Regulation and Addiction Center: Vascular Core Laboratory
07/01/2016 - 08/31/2018 (PI of Sub-Project / SP)American Heart Association NIH NHLBI5P50HL120163-05
TOPMed Informatics Resource Center - Data and Working Group Support
04/01/2017 - 04/30/2018 (Subcontract PI)University of Michigan NIH NHLBI
American Heart Association Tobacco Regulation and Addiction Center (A-TRACT) - Project 2: Cardiovascular Injury due to Tobacco Use
09/19/2013 - 06/30/2017 (PI of Sub-Project / SP)American Heart Association NIH NHLBI5P50HL120163-03
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 45 results.
Rezk-Hanna M, Warda US, Stokes AC, Fetterman J, Li J, Macey PM, Darawad M, Song Y, Ben Taleb Z, Brecht ML, Benowitz NL. Associations of Smokeless Tobacco Use With Cardiovascular Disease Risk: Insights From the Population Assessment of Tobacco and Health Study. Nicotine Tob Res. 2022 Jun 15; 24(7):1063-1070.View Related Profiles. PMID: 34999825; PMCID: PMC9199939; DOI: 10.1093/ntr/ntab258;
Wu J, Harlow AF, Wijaya D, Berman M, Benjamin EJ, Xuan Z, Hong T, Fetterman JL. The Impact of Influencers on Cigar Promotions: A Content Analysis of Large Cigar and Swisher Sweets Videos on TikTok. Int J Environ Res Public Health. 2022 Jun 09; 19(12).View Related Profiles. PMID: 35742315; PMCID: PMC9222503; DOI: 10.3390/ijerph19127064;
Xie W, Tackett AP, Berlowitz JB, Harlow AF, Kathuria H, Galiatsatos P, Fetterman JL, Cho J, Blaha MJ, Hamburg NM, Robertson RM, DeFilippis AP, Hall ME, Bhatnagar A, Benjamin EJ, Stokes AC. Association of Electronic Cigarette Use with Respiratory Symptom Development among U.S. Young Adults. Am J Respir Crit Care Med. 2022 Jun 01; 205(11):1320-1329.View Related Profiles. PMID: 35089853
Battle SL, Puiu D, Verlouw J, Broer L, Boerwinkle E, Taylor KD, Rotter JI, Rich SS, Grove ML, Pankratz N, Fetterman JL, Liu C, Arking DE. A bioinformatics pipeline for estimating mitochondrial DNA copy number and heteroplasmy levels from whole genome sequencing data. NAR Genom Bioinform. 2022 Jun; 4(2):lqac034.View Related Profiles. PMID: 35591888; PMCID: PMC9112767; DOI: 10.1093/nargab/lqac034;
Wang Y, Xu YA, Wu J, Kim HM, Fetterman JL, Hong T, McLaughlin ML. Moralization of E-cigarette Use and Regulation: A Mixed-Method Computational Analysis of Opinion Polarization. Health Commun. 2022 Jan 20; 1-11. PMID: 35057690
Ajayi TB, Childs E, Di Frances Remein C, Forbush LR, Ragasa JB, Fetterman JL, Hirsch GA, Benjamin EJ. Fostering Tobacco Regulatory Team Science through a multisite, virtual fellowship program for early-career researchers. J Clin Transl Sci. 2022; 6(1):e14.View Related Profiles. PMID: 35211340; PMCID: PMC8826010; DOI: 10.1017/cts.2021.887;
Liu C, Fetterman JL, Qian Y, Sun X, Blackwell TW, Pitsillides A, Cade BE, Wang H, Raffield LM, Lange LA, Anugu P, Abecasis G, Adrienne Cupples L, Redline S, Correa A, Vasan RS, Wilson JG, Ding J, Levy D. Presence and transmission of mitochondrial heteroplasmic mutations in human populations of European and African ancestry. Mitochondrion. 2021 09; 60:33-42.View Related Profiles. PMID: 34303007; PMCID: PMC8464516; DOI: 10.1016/j.mito.2021.07.004;
Stokes AC, Wilson AE, Lundberg DJ, Xie W, Berry KM, Fetterman JL, Harlow AF, Cozier YC, Barrington-Trimis JL, Sterling KL, Benjamin EJ, Blaha MJ, Hamburg NM, Bhatnagar A, Robertson RM. Racial/Ethnic Differences in Associations of Non-cigarette Tobacco Product Use With Subsequent Initiation of Cigarettes in US Youths. Nicotine Tob Res. 2021 05 24; 23(6):900-908.View Related Profiles. PMID: 32948872; PMCID: PMC8150136; DOI: 10.1093/ntr/ntaa170;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
2020 Boston University School of Medicine:
Outstanding Research Collaborator
2019 Boston University :
Junior Faculty Mentoring Award
2010 University of Alabama at Birmingham:
Center for Free Radical Biology Travel Award
2010 University of Alabama at Birmingham:
Ireland Research Travel Award
2009 University of Alabama at Birmingham:
Center for Free Radical Biology Travel Award
2009 University of Alabama in Birmingham:
2nd Place at the Vascular Biology and Hypertension Symposium
Available to Mentor as: (Review Mentor Role Definitions)
Dr. Fetterman is willing to mentor fellows, graduate students, and undergraduates interested in either mitochondrial genetics and physiology.
Co-Mentor or Peer Mentor
Research / Scholarly Mentor
Work / Life Integration Mentor