Jessica L. Fetterman, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Vascular Biology

PhD, University of Alabama at Birmingham




Dr. Fetterman is a basic and translational scientist studying the intersections of mitochondrial physiology, mitochondrial genetic epidemiology, and cardiovascular disease. Her work focuses on the contribution of mitochondrial genetic variation and abnormalities to cardiovascular disease in the presence of risk factors, including tobacco product use and diabetes.

Using bioinformatics methods, Dr. Fetterman discovered that several select mitochondrial genetic variants are associated with non-invasive measures of vascular function within the Framingham Heart Study (FHS). Additionally, she has applied similar methodology to select mitochondrial single variant data within Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) to determine the associations of select mitochondrial genetic variants with cardiometabolic measures in collaboration with members of the mitochondrial genetics working group. Recently, Dr. Fetterman was awarded the competitive Trans-Omics Precision Medicine (TOPMed) Analytical Support Award for early career investigators to perform comprehensive bioinformatic annotation of the mitochondrial genetic variants within the TOPMed cohorts.

Dr. Fetterman also conducts research on the impact of new and emerging tobacco products on the vasculature, particularly studies designed to inform tobacco product regulation. Some of her recent work demonstrated that tobacco product flavoring additives induce vascular endothelial dysfunction, an early indicator of cardiovascular injury. She serves as an Associate Director of Education and Training within American Heart Association Tobacco Regulation and Addiction Center. Additionally, she is the Director for the Boston University Tobacco Regulatory Science Affinity Research Collaborative, which is designed to bring together multi-disciplinary teams of scientists within Boston University to increase our understanding of tobacco product use patterns and the impact of new and emerging tobacco products on human health and disease.

Investigator
Framingham Heart Study


Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research



2019 Boston University : Junior Faculty Mentoring Award
2010 University of Alabama at Birmingham: Center for Free Radical Biology Travel Award
2010 University of Alabama at Birmingham: Ireland Research Travel Award
2009 University of Alabama at Birmingham: Center for Free Radical Biology Travel Award
2009 University of Alabama in Birmingham: 2nd Place at the Vascular Biology and Hypertension Symposium


Relations of Mitochondrial Genetic Variation and Function with Atrial Fibrillation
04/01/2019 - 03/31/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
1K01HL143142-01A1

E-cigarette-Induced Endothelial Dysfunction in Human Participants
01/01/2017 - 12/31/2018 (PI)
American Heart Association


AHA Tobacco Regulation and Addiction Center: Vascular Core Laboratory
07/01/2016 - 08/31/2018 (PI of Sub-Project / SP)
American Heart Association NIH NHLBI
5P50HL120163-05

TOPMed Informatics Resource Center - Data and Working Group Support
04/01/2017 - 04/30/2018 (Subcontract PI)
University of Michigan NIH NHLBI
5R01HL117626-05

American Heart Association Tobacco Regulation and Addiction Center (A-TRACT) - Project 2: Cardiovascular Injury due to Tobacco Use
09/19/2013 - 06/30/2017 (PI of Sub-Project / SP)
American Heart Association NIH NHLBI
5P50HL120163-03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Masaki N, Feng B, Bretón-Romero R, Inagaki E, Weisbrod RM, Fetterman JL, Hamburg NM. O-GlcNAcylation Mediates Glucose-Induced Alterations in Endothelial Cell Phenotype in Human Diabetes Mellitus. J Am Heart Assoc. 2020 Jun 16; 9(12):e014046.View Related Profiles. PMID: 32508185
     
  2. Di Frances CD, Childs E, Fetterman JL, Villanti AC, Stanton CA, Russo AR, Hirsch GA, Solis AC, Benjamin EJ. Implementing and Evaluating a Mentor Training to Improve Support for Early-Career Scholars in Tobacco Regulatory Science. Nicotine Tob Res. 2020 05 26; 22(6):1041-1045.View Related Profiles. PMID: 31095330
     
  3. Fetterman JL, Keith RJ, Palmisano JN, McGlasson KL, Weisbrod RM, Majid S, Bastin R, Stathos MM, Stokes AC, Robertson RM, Bhatnagar A, Hamburg NM. Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes. J Am Heart Assoc. 2020 May 05; 9(9):e014570.View Related Profiles. PMID: 32345096
     
  4. Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res. 2020 02 06; 22(2):264-272.View Related Profiles. PMID: 30759242
     
  5. Fetterman JL, Ballinger SW. Mitochondrial genetics regulate nuclear gene expression through metabolites. Proc Natl Acad Sci U S A. 2019 08 06; 116(32):15763-15765. PMID: 31308238
     
  6. Fetterman JL, Hamburg NM. A COmplex Cloud. Circulation. 2019 05 07; 139(19):2225-2227.View Related Profiles. PMID: 31059317
     
  7. Berry KM, Fetterman JL, Benjamin EJ, Bhatnagar A, Barrington-Trimis JL, Leventhal AM, Stokes A. Association of Electronic Cigarette Use With Subsequent Initiation of Tobacco Cigarettes in US Youths. JAMA Netw Open. 2019 02 01; 2(2):e187794.View Related Profiles. PMID: 30707232
     
  8. Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 01 03; 104(1):112-138.View Related Profiles. PMID: 30595373
     
  9. Bretón-Romero R, Weisbrod RM, Feng B, Holbrook M, Ko D, Stathos MM, Zhang JY, Fetterman JL, Hamburg NM. Liraglutide Treatment Reduces Endothelial Endoplasmic Reticulum Stress and Insulin Resistance in Patients With Diabetes Mellitus. J Am Heart Assoc. 2018 09 18; 7(18):e009379.View Related Profiles. PMID: 30371206; DOI: 10.1161/JAHA.118.009379;
     
  10. Fetterman JL, Hamburg NM. A cautionary note on electronic cigarettes and vascular health. Vasc Med. 2018 10; 23(5):426-427.View Related Profiles. PMID: 29985110
     
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 9 distinct years, with a maximum of 8 publications in 2018

YearPublications
20111
20121
20134
20142
20165
20172
20188
20193
20204


Vaping Has Same Heart Disease Risk as Smoking

The Star Online 5/9/2020

E-cigarette Use Causes as Much Vascular Damage as Smoking cigarettes

Cardiovascular Business 4/30/2020

New Study Suggests Vaping Can Damage Our Heart The Same Way Smoking Does

Medical Daily 4/30/2020

Study: E-Cigarettes as Bad for Arteries as Regular Cigarettes

Newsmax 4/30/2020

Like Tobacco, Long-term E-Cigarettes Harm Vascular Function

TctMD 4/30/2020

E-Cigarette, Traditional Cigarette Use Result in Similar Vascular Damage

MD Magazine 4/30/2020

Vaping may damage the heart just as smoking does

Science News 4/29/2020

Vaping is just as bad as smoking cigarettes for increasing the risk of heart disease ‘because it stiffens blood vessels in the same way’

Daily Mail 4/29/2020

New Study Finds E-cigarette May Cause Similar Damage to the Arteries as Tobacco Cigarettes

Yahoo News 4/29/2020

Vaping is just as bad as smoking cigarettes for increasing the risk of heart disease 'because it stiffens blood vessels in the same way’

The Daily Mail 4/29/2020

E-cigarettes fail to improve vascular profile vs. combustible cigarettes

Healio 4/29/2020

E-Cigarettes as Bad for Arteries as Regular Smokes, Study Finds

Health Day 4/29/2020

Study: E-cigarettes damage vascular function much like traditional cigarettes

News Medical: 4/29/2020

E-cig flavorings may damage lining of blood vessels

Community Health 2/15/2019

‘Fine, I’ll just vape without the nicotine.’ Not so fast! E-cig flavorings may cause damage all by themselves

Dentistry IQ 1/24/2019

E-Cigarettes Aren't Any Safer Than Regular Cigarettes, Especially With Kids Around

Moms 11/29/2018

E-cigarette flavorings may damage blood vessels and heart

WHBL 7/11/2018

E-Cigarette Flavorings May Harm Blood Vessels

MedPage Today 6/14/2018
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Mitochondria
Mitochondrial DNA
Tobacco Smoking
E-cigarettes
Tobacco Regulatory Science
Vascular Endothelium

Dr. Fetterman is willing to mentor fellows, graduate students, and undergraduates interested in either mitochondrial physiology or tobacco regulatory science.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

75 E. Newton St Evans Building
Boston MA 02118
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