PhD, University of New Hampshire

Role of the Innate Immune System in Pathogen-Induced Chronic Inflammation
08/01/2010 - 07/31/2017 (PI of Sub-Project / SP)
PI: Caroline A. Genco, PhD
NIH/National Institute of Allergy & Infectious Diseases

Boston University Clinical and Translational Science Award (CTSA) Program UL1
05/01/2008 - 04/30/2013 (PI of Sub-Project / SP)
PI: David M. Center, MD
NIH/National Center for Health Research Resources

PPARs and periodontal disease
07/01/2015 - 08/31/2016 (PI)

Oral Macrophage Function in the Context of Periodontal Disease and HIV Infection
09/25/2013 - 08/31/2016 (Activity-level PI)
PI: Andrew J. Henderson, PhD

Core B - In-Vitro Core - Role of Innate Immune System in Pathogen Induced Chronic Inflammation
08/01/2010 - 06/30/2015 (PI)
Trustees of Boston University NIH-NIAID

Project 3 - Role of Innate Immune System in Pathogen Induced Chronic Inflammation
08/01/2010 - 06/30/2015 (PI)
Trustees of Boston University NIH-NIAID

Effect of SutroVax cocktail to prevent Porphyromonas gingivalis-elicited oral bone loss-Efficacy #1
07/21/2014 - 01/20/2015 (PI)
SutroVax, Inc.

Interferon Regulatory Factors and Periodontal Disease
07/01/2011 - 06/30/2014 (PI)
5R21 DE021497-02

Infection-Elicited Oral Bone Loss: TLR2. Ontogency and Porphromomas Gingivalis
04/01/2007 - 03/31/2012 (PI)
5R01 DE018318-04

The Role of P. Gingivalis Capsule in Cell Inflamation
05/01/2003 - 01/31/2009 (PI)
5 R01 DE014774-05(A)

Oral Immunization W/ Gingipain
07/01/1999 - 01/31/2002 (PI)
5 F32 DE05739-02


Yr Title Project-Sub Proj Pubs
2021 A novel mechanism of virulence control in Porphyromonas gingivalis 1R01DE029775-01A1
2021 Microbial sphingolipids and suppression of host inflammation in periodontal disease 1R01DE031159-01
2016 PPARs and periodontal disease 5R21DE024275-02 2
2016 PPARs and periodontal disease 7R21DE024275-03 2
2015 PPARs and periodontal disease 1R21DE024275-01A1 2
2014 Oral Macrophage Function in the Context of Periodontal Disease and HIV Infection 5R56DE023950-02 6
2014 Innate Immunity, Lipid Signaling, and Chronic Infection 5P01AI078894-05-7796 31
2013 Oral Macrophage Function in the Context of Periodontal Disease and HIV Infection 1R56DE023950-01 6
2013 Innate Immunity, Lipid Signaling, and Chronic Infection 5P01AI078894-04-7796 31
2012 Interferon Regulatory Factors and Periodontal Disease 5R21DE021497-02 5
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Huang N, Shaik-Dasthagirisaheb YB, LaValley MP, Gibson FC. Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss. Mol Oral Microbiol. 2015 Dec; 30(6):438-50.View Related Profiles. PMID: 25946408; PMCID: PMC4636491; DOI: 10.1111/omi.12103;
  2. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014; 15:1176.View Related Profiles. PMID: 25540039; PMCID: PMC4367889; DOI: 10.1186/1471-2164-15-1176;
  3. Shaik-Dasthagirisaheb YB, Huang N, Weinberg EO, Shen SS, Genco CA, Gibson FC. Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis. J Periodontal Res. 2015 Feb; 50(1):89-102.View Related Profiles. PMID: 24862405; PMCID: PMC4242805; DOI: 10.1111/jre.12185;
  4. Shaik-Dasthagirisaheb YB, Huang N, Gibson FC. Inflammatory response to Porphyromonas gingivalis partially requires interferon regulatory factor (IRF) 3. Innate Immun. 2014 Apr; 20(3):312-9.View Related Profiles. PMID: 23803413; PMCID: PMC3867555; DOI: 10.1177/1753425913492180;
  5. Papadopoulos G, Weinberg EO, Massari P, Gibson FC, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013 Feb 1; 190(3):1148-57.View Related Profiles. PMID: 23264656; PMCID: PMC3549226; DOI: 10.4049/jimmunol.1202511;
  6. Shaik-Dasthagirisaheb YB, Huang N, Baer MT, Gibson FC. Role of MyD88-dependent and MyD88-independent signaling in Porphyromonas gingivalis-elicited macrophage foam cell formation. Mol Oral Microbiol. 2013 Feb; 28(1):28-39.View Related Profiles. PMID: 23194377; PMCID: PMC3543481; DOI: 10.1111/omi.12003;
  7. Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1; 189(7):3681-8.View Related Profiles. PMID: 22956579; PMCID: PMC3448820; DOI: 10.4049/jimmunol.1201541;
  8. Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC, Hamilton JA, Genco CA. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis. 2011 Mar; 215(1):52-9.View Related Profiles. PMID: 21251656; PMCID: PMC3057233; DOI: 10.1016/j.atherosclerosis.2010.12.009;
  9. Shaik-Dasthagirisaheb YB, Kantarci A, Gibson FC. Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis. Immun Ageing. 2010; 7:15.View Related Profiles. PMID: 21114831; PMCID: PMC3001696; DOI: 10.1186/1742-4933-7-15;
  10. Hayashi C, Gudino CV, Gibson FC, Genco CA. Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010 Oct; 25(5):305-16.View Related Profiles. PMID: 20883220; PMCID: PMC2951292; DOI: 10.1111/j.2041-1014.2010.00582.x;
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