Andrew Henderson | Profiles RNS

Andrew J. Henderson, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Infectious Diseases

PhD, University of California, Riverside
MS, University of California, Riverside
BS, University of California, Riverside

Websites

	Microbiology Faculty
	Immunology Training Program Faculty
	Program in Medical Disorders Faculty

ORCID : 0000-0002-9299-5302

My research focuses on cellular mechanisms that regulate HIV replication and transcription. Active projects in the lab include elucidating T cell costimulatory signal transduction cascades that positively and negatively regulate HIV transcription, determining mechanisms by which HIV circumvents anti-inflammatory signals to promote HIV replication and AIDS-associated inflammatory diseases and characterizing the transcriptional status of HIV provirus in T cell and macrophage subsets. Although, HIV is our primary experimental system, our research provides general insights into signal transduction, tissue-specific gene expression, immune cell function and mechanisms that contribute to inflammatory disorders and autoimmunity. Below highlights some of the current on-going projects in the lab:

T cell signals regulate HIV replication. T cell activation through the T cell receptor and costimulatory molecules, including CD28, influences susceptibility of T cells to HIV infection as well as proviral transcription. Incomplete T cell receptor signaling has been proposed to be a mechanism that contributes to proviral latency. We hypothesize that CD28 engagement results in distinct signaling cascades that have very different consequences for HIV transcription. We are actively characterizing signaling events emanating from critical tyrosine residues within the cytoplasmic tail of CD28 that either inhibit or induce HIV transcription to fully appreciate how costimulatory signals impact HIV transcription. In addition, we are characterizing the transcriptional machinery that regulates HIV expression in response to T cell signals. Understanding mechanisms by which CD28 regulates HIV transcription will further define pathways associated with this receptor as well as identify putative upstream signal transduction events critical for controlling HIV expression.

Related projects have suggested that non-receptor tyrosine kinases necessary for T cell activation and function, such as the Src kinase Lck and the Tec kinase Itk mediate efficient release of HIV. The mechanisms by which these kinases influence these late steps of HIV virus replication are actively being studied.

Regulation of HIV transcription elongation. HIV provirus is regulated at the level of transcription and involves changes in transcription initiation, chromatin organization and elongation. In particular, transcription elongation has been demonstrated to be a limiting step for HIV expression and overcoming this block is the primary activity of the viral factor Tat, which through the recruitment of P-TEFb to the LTR, post-translationally modifies RNA polymerase II and associated factors to increase processive transcription. Whether this initial lack of RNA polymerase II processivity represents proximal paused RNA polymerase II, premature termination, or both has not been resolved. Recent work from our lab shows that negative elongation factor NELF and the transcription termination factor Pcf11 repress HIV transcription. We hypothesize that the coordinate control of RNA Polymerase II activity and premature transcription termination coupled with chromatin changes create key check-points for HIV transcription that directly contributes to proviral transcriptional latency. In addition, we posit that there are cellular signals that extinguish HIV expression by inducing promoter proximal pausing and premature termination. Using a receptor tyrosine kinase that represses HIV expression, we are mapping signaling pathways that are upstream of transcription initiation, elongation and termination. Understanding the regulation of HIV transcription elongation will provide novel cellular targets for controlling and purging HIV in different cellular reservoirs.

Assistant Dean
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Oral Health Sciences

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston Medical Center

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Co-Director
Boston University
Clinical and Translational Science Institute
Integrated Pilot Grant Award Program

Persistent HIV-1 expression and microglia dysfunction
08/01/2021 - 05/31/2026 (Multi PI of Sub-Project / SP)
PI: Suryaram Gummuluru, PhD
Boston Medical Center Corporation NIH NIDA
5R01DA055488-03

BU PREP
02/01/2020 - 01/31/2025 (PI)
NIH/National Institute of General Medical Sciences
5R25GM125511-04

BU-UL Partnership to Enhance Emerging Epidemic Virus Research in Liberia (BULEEVR)
07/22/2019 - 04/30/2024 (Multi-PI)
PI: Andrew J. Henderson, PhD
NIH/Fogarty International Center
5U2RTW011293-05

BU-UL Partnership to Enhance Emerging Epidemic Virus Research in Liberia (BULEEVR)
09/08/2017 - 08/31/2019 (Multi-PI)
PI: Andrew J. Henderson, PhD
NIH/Fogarty International Center
1D71TW010785-01

Pre notification The Providence/Boston Center for AIDS Research (CFAR) competitive renewal
07/01/2023 - 06/30/2028 (PI)
The Miriam Hospital National Institute o

Persistent HIV-1 expression and microglia dysfunction
08/01/2021 - 05/31/2026 (PI)
National Institute on Drug Abuse/NIH/DHHS
1R01DA055488-01

Training of Ugandans in Basic and Translational Research on TB and Emerging Infectious Diseases
01/01/2020 - 12/31/2024 (PI)
Rutgers The State University of New Jersey Fogarty Internationa
7D43TW009093-07

Effect of opioid use disorder on HIV latent reservoirs and immune dysfunction assessed by single-cell transcriptomics
06/01/2021 - 05/24/2024 (PI)
Trustees of Boston University,CRC National Institute o

Signals that establish and maintain HIV latency
05/01/2020 - 04/30/2024 (PI)
National Institutes of Health/DHHS/NIH National Institute o
5R01AI138960-05

Providence Boston Center for AIDS Research (CFAR)
07/01/2019 - 06/30/2023 (Multi-PI)
PI: Andrew J. Henderson, PhD
The Miriam Hospital National Institute o
5P30AI042853-21

Effect of opioid use disorder on HIV latent reservoirs and immune dysfunction assessed by single…
06/01/2019 - 05/31/2022 (PI)
Trustees of Boston University,CRC National Institute o
1R61DA047032-01

Overcoming HIV-1 transcriptional latency in unresponsive CD4 T cells
08/01/2017 - 07/31/2021 (PI)
University of Alabama National Institute o
5R01AI122842-04

Disabling HIV Provirus by Promoting Chromatinization
07/01/2017 - 06/30/2019 (PI)
amfAR / The Foundation for AIDS Reasearch

Transcription mechanisms that contribute to HIV-1 Latency
04/01/2013 - 03/31/2019 (PI)
NIH-NIAID
4R01AI097117-04

Showing 10 of 22 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	BU PREP	5R25GM125511-05
2023	Persistent HIV-1 expression and microglia dysfunction	5R01DA055488-03
2023	BU PREP	5R25GM125511-04
2023	BU-UL Partnership to Enhance Emerging Epidemic Virus Research in Liberia (BULEEVR)	5U2RTW011293-05
2022	Persistent HIV-1 expression and microglia dysfunction	5R01DA055488-02
2022	BU PREP	5R25GM125511-03
2022	BU-UL Partnership to Enhance Emerging Epidemic Virus Research in Liberia (BULEEVR)	5U2RTW011293-04
2022	Effect of opioid use disorder on HIV latent reservoirs and immune dysfunction assessed by single-cell transcriptomics	5R33DA047032-05
2022	Signals that establish and maintain HIV latency	5R01AI138960-05
2021	Persistent HIV-1 expression and microglia dysfunction	1R01DA055488-01

Showing 10 of 52 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Basukala B, Rossi S, Bendiks S, Gnatienko N, Patts G, Krupitsky E, Lioznov D, So-Armah K, Sagar M, Cheng C, Henderson AJ. Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. Viruses. 2023 Feb 01; 15(2).View Related Profiles.

Henderson, Andrew
So-Armah, Kaku
Sagar, Manish

PMID: 36851631; PMCID: PMC9961149; DOI: 10.3390/v15020415;

Kuniholm J, Coote C, Henderson AJ. Defective HIV-1 genomes and their potential impact on HIV pathogenesis. Retrovirology. 2022 Jun 28; 19(1):13. PMID: 35764966; PMCID: PMC9238239; DOI: 10.1186/s12977-022-00601-8;

Dalecki AG, Greer BD, Duverger A, Strange EL, Carlin E, Wagner F, Shi B, Lowman KE, Perez M, Tidwell C, Kaczmarek Michaels K, Giattina S, Bossmann SH, Henderson AJ, Hu H, Kutsch O. Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability. J Virol. 2022 03 09; 96(5):e0197421. PMID: 35019721; PMCID: PMC8906408; DOI: 10.1128/jvi.01974-21;

Kuniholm J, Armstrong E, Bernabe B, Coote C, Berenson A, Patalano SD, Olson A, He X, Lin NH, Fuxman Bass JI, Henderson AJ. Intragenic proviral elements support transcription of defective HIV-1 proviruses. PLoS Pathog. 2021 12; 17(12):e1009982.View Related Profiles.

Olson, Alex
Henderson, Andrew
Lin, Nina

PMID: 34962974; PMCID: PMC8746790; DOI: 10.1371/journal.ppat.1009982;

Ragan EJ, McCallum C, Marathe J, Cole M, Hofman M, Henderson AJ, Flack T, Miller NS, Burks EJ, Zhao GQ, Denis R, Lin NH, Jacobson KR, Andry CD, Pelton SI, Duffy ER, Bhadelia N. Pandemic Response Requires Research Samples: A U.S. Safety-Net Hospital's Experience and Call for National Action. Ann Intern Med. 2021 12; 174(12):1727-1732.View Related Profiles.

Henderson, Andrew
Duffy, Elizabeth
Burks, Eric
Marathe, Jai
Jacobson, Karen
Bhadelia, Nahid
Miller, Nancy
Lin, Nina
Pelton, Stephen

PMID: 34724402; DOI: 10.7326/M21-2857;

Pedro KD, Agosto LM, Sewell JA, Eberenz KA, He X, Fuxman Bass JI, Henderson AJ. A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2. Proc Natl Acad Sci U S A. 2021 03 16; 118(11).View Related Profiles.

Henderson, Andrew
Pedro, Kyle
He, Xianbao

PMID: 33836568; PMCID: PMC7980386; DOI: 10.1073/pnas.2012835118;

Santoso CS, Li Z, Lal S, Yuan S, Gan KA, Agosto LM, Liu X, Pro SC, Sewell JA, Henderson A, Atianand MK, Fuxman Bass JI. Comprehensive mapping of the human cytokine gene regulatory network. Nucleic Acids Res. 2020 12 02; 48(21):12055-12073. PMID: 33179750; PMCID: PMC7708076; DOI: 10.1093/nar/gkaa1055;

Olson A, Basukala B, Lee S, Gagne M, Wong WW, Henderson AJ. Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9. Viruses. 2020 10 12; 12(10).View Related Profiles.

Olson, Alex
Henderson, Andrew
Gagne, Matthew
Wong, Wilson

PMID: 33053801; PMCID: PMC7600714; DOI: 10.3390/v12101154;

He X, Eddy JJ, Jacobson KR, Henderson AJ, Agosto LM. Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection. J Infect Dis. 2020 10 01; 222(9):1550-1560.View Related Profiles.

Henderson, Andrew
Jacobson, Karen
He, Xianbao

PMID: 32417884; PMCID: PMC7529013; DOI: 10.1093/infdis/jiaa257;

Karagiannis TT, Cleary JP, Gok B, Henderson AJ, Martin NG, Yajima M, Nelson EC, Cheng CS. Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program. Nat Commun. 2020 05 26; 11(1):2611. PMID: 32457298; PMCID: PMC7250875; DOI: 10.1038/s41467-020-16159-y;

Showing 10 of 72 results. Show More

Olson A, Basukala B, Wong WW, Henderson AJ. Targeting HIV-1 proviral transcription. Curr Opin Virol. 2019 10; 38:89-96.View Related Profiles.

Olson, Alex
Henderson, Andrew
Wong, Wilson

PMID: 31473372; PMCID: PMC6854310; DOI: 10.1016/j.coviro.2019.07.011;

Gagne M, Michaels D, Schiralli Lester GM, Gummuluru S, Wong WW, Henderson AJ. Strength of T cell signaling regulates HIV-1 replication and establishment of latency. PLoS Pathog. 2019 05; 15(5):e1007802.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian
Gagne, Matthew
Gummuluru, Suryaram
Wong, Wilson

PMID: 31116788; PMCID: PMC6548398; DOI: 10.1371/journal.ppat.1007802;

Pedro KD, Henderson AJ, Agosto LM. Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir. Virus Res. 2019 05; 265:115-121.View Related Profiles.

Henderson, Andrew
Pedro, Kyle
Agosto Vazquez, Luis

PMID: 30905686; PMCID: PMC6467521; DOI: 10.1016/j.virusres.2019.03.014;

Agosto LM, Herring MB, Mothes W, Henderson AJ. HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact. Cell Rep. 2018 08 21; 24(8):2088-2100.View Related Profiles.

Henderson, Andrew
Agosto Vazquez, Luis

PMID: 30134170

Agosto LM, Henderson AJ. CD4+ T Cell Subsets and Pathways to HIV Latency. AIDS Res Hum Retroviruses. 2018 09; 34(9):780-789.View Related Profiles.

Henderson, Andrew
Agosto Vazquez, Luis

PMID: 29869531; PMCID: PMC6152855; DOI: 10.1089/aid.2018.0105;

Pena-Cruz V, Agosto LM, Akiyama H, Olson A, Moreau Y, Larrieux JR, Henderson A, Gummuluru S, Sagar M. HIV-1 replicates and persists in vaginal epithelial dendritic cells. J Clin Invest. 2018 08 01; 128(8):3439-3444.View Related Profiles.

Olson, Alex
Henderson, Andrew
Akiyama, Hisashi
Larrieux, Jean-Robert
Agosto Vazquez, Luis
Sagar, Manish
Gummuluru, Suryaram

PMID: 29723162; PMCID: PMC6063466; DOI: 10.1172/JCI98943;

Graci JD, Michaels D, Chen G, Schiralli Lester GM, Nodder S, Weetall M, Karp GM, Gu Z, Colacino JM, Henderson AJ. Identification of benzazole compounds that induce HIV-1 transcription. PLoS One. 2017; 12(6):e0179100.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian

PMID: 28658263; PMCID: PMC5489165; DOI: 10.1371/journal.pone.0179100;

Miller CM, Akiyama H, Agosto LM, Emery A, Ettinger CR, Swanstrom RI, Henderson AJ, Gummuluru S. Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells. J Virol. 2017 Jul 01; 91(13).View Related Profiles.

Henderson, Andrew
Miller, Caitlin
Akiyama, Hisashi
Agosto Vazquez, Luis
Gummuluru, Suryaram

PMID: 28424288; PMCID: PMC5469257; DOI: 10.1128/JVI.00051-17;

Agosto LM, Hirnet JB, Michaels DH, Shaik-Dasthagirisaheb YB, Gibson FC, Viglianti G, Henderson AJ. Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages. Virology. 2016 Dec; 499:72-81.View Related Profiles.

Henderson, Andrew
Viglianti, Gregory
Hirnet, Juliane
Agosto Vazquez, Luis
Shaik-Dasthagirisheb, Yazdani

PMID: 27639573; PMCID: PMC5126732; DOI: 10.1016/j.virol.2016.09.007;

Papadopoulos G, Shaik-Dasthagirisaheb YB, Huang N, Viglianti GA, Henderson AJ, Kantarci A, Gibson FC. Immunologic environment influences macrophage response to Porphyromonas gingivalis. Mol Oral Microbiol. 2017 Jun; 32(3):250-261.View Related Profiles.

Henderson, Andrew
Papadopoulos, George
Viglianti, Gregory
Huang, Nasi
Shaik-Dasthagirisheb, Yazdani

PMID: 27346827; PMCID: PMC5192000; DOI: 10.1111/omi.12168;

Agosto LM, Gagne M, Henderson AJ. Impact of Chromatin on HIV Replication. Genes (Basel). 2015; 6(4):957-76.View Related Profiles.

Henderson, Andrew
Agosto Vazquez, Luis
Gagne, Matthew

PMID: 26437430; PMCID: PMC4690024; DOI: 10.3390/genes6040957;

Kaczmarek Michaels K, Wolschendorf F, Schiralli Lester GM, Natarajan M, Kutsch O, Henderson AJ. RNAP II processivity is a limiting step for HIV-1 transcription independent of orientation to and activity of endogenous neighboring promoters. Virology. 2015 Dec; 486:7-14.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian

PMID: 26379089; PMCID: PMC4679410; DOI: 10.1016/j.virol.2015.08.027;

Kaczmarek Michaels K, Natarajan M, Euler Z, Alter G, Viglianti G, Henderson AJ. Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells. J Immunol. 2015 Apr 1; 194(7):3267-74.View Related Profiles.

Henderson, Andrew
Viglianti, Gregory
Kaczmarek, Katarzyna

PMID: 25710909; PMCID: PMC4369419; DOI: 10.4049/jimmunol.1402581;

Collins MH, Henderson AJ. Transcriptional regulation and T cell exhaustion. Curr Opin HIV AIDS. 2014 Sep; 9(5):459-63. PMID: 25010896; DOI: 10.1097/COH.0000000000000091;

Kaczmarek K, Morales A, Henderson AJ. T Cell Transcription Factors and Their Impact on HIV Expression. Virology (Auckl). 2013 Sep 24; 2013(4):41-47.View Related Profiles.

Henderson, Andrew
Kaczmarek, Katarzyna

PMID: 24436634; PMCID: PMC3891646; DOI: 10.4137/VRT.S12147;

Cary DC, Clements JE, Henderson AJ. RON receptor tyrosine kinase, a negative regulator of inflammation, is decreased during simian immunodeficiency virus-associated central nervous system disease. J Immunol. 2013 Oct 15; 191(8):4280-7. PMID: 24043899; PMCID: PMC3819118; DOI: 10.4049/jimmunol.1300797;

Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6; 288(36):25995-6003.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian
Wasserman, Gregory

PMID: 23884411; PMCID: PMC3764804; DOI: 10.1074/jbc.M113.496489;

Katarzyna Kaczmarek, Ayana Morales and Andrew J. Henderson. T Cell Transcription Factors and Their Impact on HIV Expression. Virology: Research and Treatment. 2013; 4:41-47.

Schiralli Lester GM, Akiyama H, Evans E, Singh J, Gummuluru S, Henderson AJ. Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization. Virology. 2013 Feb 5; 436(1):235-43.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian
Akiyama, Hisashi
Gummuluru, Suryaram

PMID: 23260110; PMCID: PMC3598624; DOI: 10.1016/j.virol.2012.11.015;

Schiralli Lester GM, Henderson AJ. Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency. Mol Biol Int. 2012; 2012:614120.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian

PMID: 22701796; PMCID: PMC3371693; DOI: 10.1155/2012/614120;

Narayan V, Ravindra KC, Chiaro C, Cary D, Aggarwal BB, Henderson AJ, Prabhu KS. Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication. J Mol Biol. 2011 Jul 29; 410(5):972-83. PMID: 21763500; PMCID: PMC3140654; DOI: 10.1016/j.jmb.2011.04.013;

Natarajan M, August A, Henderson AJ. Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells. J Biol Chem. 2010 Jun 4; 285(23):17338-47. PMID: 20368329; PMCID: PMC2878497; DOI: 10.1074/jbc.M109.085324;

Kalantari P, Narayan V, Henderson AJ, Prabhu KS. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. FASEB J. 2009 Aug; 23(8):2366-73. PMID: 19299483; PMCID: PMC2717765; DOI: 10.1096/fj.08-124982;

Kalantari P, Narayan V, Natarajan SK, Muralidhar K, Gandhi UH, Vunta H, Henderson AJ, Prabhu KS. Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages. J Biol Chem. 2008 Nov 28; 283(48):33183-90. PMID: 18835810; PMCID: PMC2586244; DOI: 10.1074/jbc.M807403200;

Strasner AB, Natarajan M, Doman T, Key D, August A, Henderson AJ. The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane. J Immunol. 2008 Sep 1; 181(5):3706-13. PMID: 18714047; PMCID: PMC2587142; DOI: 10.4049/jimmunol.181.5.3706;

Kalantari P, Harandi OF, Hankey PA, Henderson AJ. HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation. J Immunol. 2008 Jul 15; 181(2):1548-55. PMID: 18606710; PMCID: PMC2536764; DOI: 10.4049/jimmunol.181.2.1548;

Readinger JA, Schiralli GM, Jiang JK, Thomas CJ, August A, Henderson AJ, Schwartzberg PL. Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A. 2008 May 6; 105(18):6684-9.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian

PMID: 18443296; PMCID: PMC2365562; DOI: 10.1073/pnas.0709659105;

Klatt A, Zhang Z, Kalantari P, Hankey PA, Gilmour DS, Henderson AJ. The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity. J Immunol. 2008 Feb 1; 180(3):1670-7. PMID: 18209063

Zhang Z, Klatt A, Henderson AJ, Gilmour DS. Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression. Genes Dev. 2007 Jul 1; 21(13):1609-14. PMID: 17606639; PMCID: PMC1899470; DOI: 10.1101/gad.1542707;

Zhang Z, Klatt A, Gilmour DS, Henderson AJ. Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex. J Biol Chem. 2007 Jun 8; 282(23):16981-8. PMID: 17442680

Peng HH, Liang S, Henderson AJ, Dong C. Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. Exp Cell Res. 2007 Feb 1; 313(3):551-9. PMID: 17141217; PMCID: PMC1892538; DOI: 10.1016/j.yexcr.2006.10.030;

Gekonge BN, Schiralli G, Schlegel RA, Henderson AJ. Signal transduction induced by apoptotic cells inhibits HIV transcription in monocytes/macrophages. J Leukoc Biol. 2006 Oct; 80(4):953-60.View Related Profiles.

Henderson, Andrew
Schiralli Lester, Gillian

PMID: 16885500

Wilson RL, Fuentes SM, Wang P, Taddeo EC, Klatt A, Henderson AJ, He B. Function of small hydrophobic proteins of paramyxovirus. J Virol. 2006 Feb; 80(4):1700-9. PMID: 16439527; PMCID: PMC1367141; DOI: 10.1128/JVI.80.4.1700-1709.2006;

Ragin MJ, Hu J, Henderson AJ, August A. A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylation. BMC Immunol. 2005; 6:19. PMID: 16042784; PMCID: PMC1200558; DOI: 10.1186/1471-2172-6-19;

Yang P, Henderson AJ. Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes. Virology. 2005 Jun 5; 336(2):219-28. PMID: 15892963

Tsutsui S, Noorbakhsh F, Sullivan A, Henderson AJ, Warren K, Toney-Earley K, Waltz SE, Power C. RON-regulated innate immunity is protective in an animal model of multiple sclerosis. Ann Neurol. 2005 Jun; 57(6):883-95. PMID: 15929040

Peng HH, Hodgson L, Henderson AJ, Dong C. Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly. Front Biosci. 2005; 10:1597-606. PMID: 15769649; PMCID: PMC2782934

Lee ES, Kalantari P, Tsutsui Section S, Klatt A, Holden J, Correll PH, Power Section C, Henderson AJ. RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS. J Immunol. 2004 Dec 1; 173(11):6864-72. PMID: 15557181

Callahan MK, Halleck MS, Krahling S, Henderson AJ, Williamson P, Schlegel RA. Phosphatidylserine expression and phagocytosis of apoptotic thymocytes during differentiation of monocytic cells. J Leukoc Biol. 2003 Nov; 74(5):846-56. PMID: 12960250

Cook JA, Albacker L, August A, Henderson AJ. CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation. J Biol Chem. 2003 Sep 12; 278(37):35812-8. PMID: 12842899

Callahan MK, Popernack PM, Tsutsui S, Truong L, Schlegel RA, Henderson AJ. Phosphatidylserine on HIV envelope is a cofactor for infection of monocytic cells. J Immunol. 2003 May 1; 170(9):4840-5. PMID: 12707367

Hodgson L, Henderson AJ, Dong C. Melanoma cell migration to type IV collagen requires activation of NF-kappaB. Oncogene. 2003 Jan 9; 22(1):98-108. PMID: 12527912; PMCID: PMC2778843

Hogan TH, Nonnemacher MR, Krebs FC, Henderson A, Wigdahl B. HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific. Biomed Pharmacother. 2003 Jan; 57(1):41-8. PMID: 12642036

Nonnemacher MR, Hogan TH, Quiterio S, Wigdahl B, Henderson A, Krebs FC. Identification of binding sites for members of the CCAAT/enhancer binding protein transcription factor family in the simian immunodeficiency virus long terminal repeat. Biomed Pharmacother. 2003 Jan; 57(1):34-40. PMID: 12642035

Lee ES, Sarma D, Zhou H, Henderson AJ. CCAAT/enhancer binding proteins are not required for HIV-1 entry but regulate proviral transcription by recruiting coactivators to the long-terminal repeat in monocytic cells. Virology. 2002 Jul 20; 299(1):20-31. PMID: 12167337

Cook JA, August A, Henderson AJ. Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. J Immunol. 2002 Jul 1; 169(1):254-60. PMID: 12077252

Popernack PM, Truong LT, Kamphuis M, Henderson AJ. Ectopic expression of CCAAT/enhancer binding protein beta (C/EBPbeta) in long-term bone marrow cultures induces granulopoiesis and alters stromal cell function. J Hematother Stem Cell Res. 2001 Oct; 10(5):631-42. PMID: 11672509

Lee ES, Zhou H, Henderson AJ. Endothelial cells enhance human immunodeficiency virus type 1 replication in macrophages through a C/EBP-dependent mechanism. J Virol. 2001 Oct; 75(20):9703-12. PMID: 11559803; PMCID: PMC114542

Ross HL, Nonnemacher MR, Hogan TH, Quiterio SJ, Henderson A, McAllister JJ, Krebs FC, Wigdahl B. Interaction between CCAAT/enhancer binding protein and cyclic AMP response element binding protein 1 regulates human immunodeficiency virus type 1 transcription in cells of the monocyte/macrophage lineage. J Virol. 2001 Feb; 75(4):1842-56. PMID: 11160683; PMCID: PMC114094

Montecino-Rodriguez E, Truong LT, Henderson AJ. Long-term bone marrow cultures provide access to early lymphoid progenitors. J Hematother Stem Cell Res. 2001 Feb; 10(1):107-14. PMID: 11276364

Hodgson L, Qiu W, Dong C, Henderson AJ. Use of green fluorescent protein-conjugated beta-actin as a novel molecular marker for in vitro tumor cell chemotaxis assay. Biotechnol Prog. 2000 Nov-Dec; 16(6):1106-14. PMID: 11101341; PMCID: PMC2852904

Henderson A, Calame K. Transcriptional regulation during B cell development. Annu Rev Immunol. 1998; 16:163-200. PMID: 9597128

Henderson AJ, Calame KL. CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4(+) T cells. Proc Natl Acad Sci U S A. 1997 Aug 5; 94(16):8714-9. PMID: 9238043; PMCID: PMC23095

Merrell K, Wells S, Henderson A, Gorman J, Alt F, Stall A, Calame K. The absence of the transcription activator TFE3 impairs activation of B cells in vivo. Mol Cell Biol. 1997 Jun; 17(6):3335-44. PMID: 9154832; PMCID: PMC232186

Henderson AJ, Connor RI, Calame KL. C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines. Immunity. 1996 Jul; 5(1):91-101. PMID: 8758898

Cooper C, Henderson A, Artandi S, Avitahl N, Calame K. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res. 1995 Nov 11; 23(21):4371-7. PMID: 7501458; PMCID: PMC307392

Henderson AJ, Zou X, Calame KL. C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes. J Virol. 1995 Sep; 69(9):5337-44. PMID: 7636977; PMCID: PMC189374

Henderson AJ, Calame KL. Lessons in transcriptional regulation learned from studies on immunoglobulin genes. Crit Rev Eukaryot Gene Expr. 1995; 5(3-4):255-80. PMID: 8834227

Henderson AJ, McDougall S, Leiden J, Calame KL. GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer. Mol Cell Biol. 1994 Jun; 14(6):4286-94. PMID: 8196665; PMCID: PMC358795

Henderson AJ, Narayanan R, Collins L, Dorshkind K. Status of kappa L chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J Immunol. 1992 Sep 15; 149(6):1973-9. PMID: 1381391

Henderson AJ, Johnson A, Dorshkind K. Functional characterization of two stromal cell lines that support B lymphopoiesis. J Immunol. 1990 Jul 15; 145(2):423-8. PMID: 1694879

Henderson AJ, Dorshkind K. In vitro models of B lymphocyte development. Semin Immunol. 1990 May; 2(3):181-7. PMID: 2129906

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 31 distinct years, with a maximum of 6 publications in 2003

Bar chart showing 72 publications over 31 distinct years, with a maximum of 6 publications in 2003

Year	Publications
1990	2
1992	1
1994	1
1995	3
1996	1
1997	2
1998	1
2000	1
2001	4
2002	2
2003	6
2004	1
2005	4
2006	3
2007	2
2008	5
2009	1
2010	1
2011	1
2012	2
2013	4
2014	1
2015	3
2016	2
2017	2
2018	3
2019	3
2020	4
2021	3
2022	2
2023	1