Neema Yazdani, PhD
Project Manager
Amgen




Laboratory of Addiction Genetics (Advisor: Dr. Camron Bryant), Department of Pharmacology, Boston University, Boston, MA

Graduate student (PhD); 2013-present
• Utilized TALENs gene editing to generate Hnrnph1 & Rufy1 knock-out mice
• Established & managed large-scale mouse breeding colonies for multiple strains
• Developed custom qPCR, PCR, & restriction enzyme-based genotyping protocols
• Mastered open field, elevated plus maze, & conditioned place preference behavioral assessments
• Executed bioinformatic transcriptome & spice variant analyses
• Established & optimized a mouse brain tissue immunohistochemistry pipeline
• Spearheaded interdisciplinary collaborations with local & offsite laboratories
• Mentored undergraduates in various laboratory & behavioral techniques

Department of Biology (Advisor: Dr. Eduardo Macagno), UCSD, La Jolla, CA

Undergraduate researcher & graduate student (M.S.); 2011-2012
• Mastered recombinant DNA techniques including primer design, PCR, restriction enzyme digests, gel electrophoresis, insert-vector ligations & bacterial cloning
• Conducted single-neuron injections & leech embryo dissections
• Delivered expression vectors on gold particles biolistically to neurons in vivo using a gene gun
• Executed neural immunohistology & confocal imaging
• Designed & optimized RNA probes for in situ hybridization of newly discovered Innexin genes

Saier Lab, Department of Biology, Section of Molecular Biology, UCSD, La Jolla, CA

Undergraduate researcher; 2008
• Trained in using NCBI GenBank, BLAST, & ClustalW online programs
• Categorized bacterial monovalent cation transporters by amino acid homology

Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Program in Biomedical Neuroscience


Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Pharmacology, Physiology & Biophysics




Functional Mechanisms of Hnrnph1 in Methamphetamine Addictive Behaviors
04/01/2016 - 06/07/2017 (PI)
NIH/National Institute on Drug Abuse
5F31DA040324-02



Title


Yr Title Project-Sub Proj Pubs
2017 Functional mechanisms of Hnrnph1 in methamphetamine addictive behaviors 5F31DA040324-02 3
2016 Functional mechanisms of Hnrnph1 in methamphetamine addictive behaviors 1F31DA040324-01A1 3

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Bryant CD, Healy AF, Ruan QT, Coehlo MA, Lustig E, Yazdani N, Luttik KP, Tran T, Swancy I, Brewin LW, Chen MM, Szumlinski KK. Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice. Genes Brain Behav. 2021 03; 20(3):e12711.View Related Profiles. PMID: 33145940
     
  2. Ruan QT, Yazdani N, Reed ER, Beierle JA, Peterson LP, Luttik KP, Szumlinski KK, Johnson WE, Ash PEA, Wolozin B, Bryant CD. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. FASEB J. 2020 07; 34(7):9223-9244.View Related Profiles. PMID: 32401417; PMCID: PMC8006537; DOI: 10.1096/fj.202000092R;
     
  3. Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles. PMID: 31704785; PMCID: PMC6939476; DOI: 10.1523/JNEUROSCI.1808-19.2019;
     
  4. Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neurosci Lett. 2018 09 25; 684:109-114.View Related Profiles. PMID: 30003938; PMCID: PMC6330092; DOI: 10.1016/j.neulet.2018.07.015;
     
  5. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 01; 21(1):72-80.View Related Profiles. PMID: 29273772; PMCID: PMC5745051; DOI: 10.1038/s41593-017-0022-z;
     
  6. Goldberg LR, Kirkpatrick SL, Yazdani N, Luttik KP, Lacki OA, Keith Babbs R, Jenkins DF, Evan Johnson W, Bryant CD. Casein kinase 1-epsilon deletion increases mu opioid receptor-dependent behaviors and binge eating1. Genes Brain Behav. 2017 Sep; 16(7):725-738.View Related Profiles. PMID: 28594147; PMCID: PMC6180211; DOI: 10.1111/gbb.12397;
     
  7. Kirkpatrick SL, Goldberg LR, Yazdani N, Babbs RK, Wu J, Reed ER, Jenkins DF, Bolgioni AF, Landaverde KI, Luttik KP, Mitchell KS, Kumar V, Johnson WE, Mulligan MK, Cottone P, Bryant CD. Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. Biol Psychiatry. 2017 May 01; 81(9):757-769.View Related Profiles. PMID: 27914629; PMCID: PMC5386810; DOI: 10.1016/j.biopsych.2016.10.021;
     
  8. Yazdani N, Shen Y, Johnson WE, Bryant CD. Striatal transcriptome analysis of a congenic mouse line (chromosome 11: 50-60Mb) exhibiting reduced methamphetamine sensitivity. Genom Data. 2016 Jun; 8:77-80.View Related Profiles. PMID: 27222804; PMCID: PMC4856813; DOI: 10.1016/j.gdata.2016.03.009;
     
  9. Bryant CD, Yazdani N. RNA-binding proteins, neural development and the addictions. Genes Brain Behav. 2016 Jan; 15(1):169-86.View Related Profiles. PMID: 26643147; PMCID: PMC4944654; DOI: 10.1111/gbb.12273;
     
  10. Yazdani N, Parker CC, Shen Y, Reed ER, Guido MA, Kole LA, Kirkpatrick SL, Lim JE, Sokoloff G, Cheng R, Johnson WE, Palmer AA, Bryant CD. Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. PLoS Genet. 2015 Dec; 11(12):e1005713.View Related Profiles. PMID: 26658939; PMCID: PMC4675533; DOI: 10.1371/journal.pgen.1005713;
     
Showing 10 of 14 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 14 publications over 8 distinct years, with a maximum of 3 publications in 2016

YearPublications
20122
20132
20151
20163
20172
20181
20191
20202


2015 Boston University: International Behavioural and Neural Genetics Society (IBANGS) Travel Award & Talk ($1,500)
2015 Boston University: BU Genome Science Institute Research Symposium Award & Talk ($100)
2014-2016 Boston University: Transformative Training Program in Addiction Science (TTPAS) Fellowship ($64,000)
2014 Boston University: BU Genome Science Institute Research Symposium Poster Award ($100)
2014 Boston University: IBANGS Travel Award ($400)
2014 Boston University: TTPAS Travel Award for Jackson Laboratory “Short Course on Addiction Genetics” ($1,800)
2013-2014 Boston University: NIGMS Training Program in Biomolecular Pharmacology, 5T32GM008541-18 ($31,000
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72 E. Concord St Evans Building
Boston MA 02118
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