Maria Cardamone, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Turin

I’m currently a Research Assistant Professor in Dr. Valentina Perissi's Laboratory at Boston University School of Medicine. I hold a “Laurea” in Molecular Biology (equivalent to a B.S. and a Master) and a PhD in Complex System in Molecular Biology from the University of Turin in Italy. As part of my doctoral fellowship, I spend the last two years of my doctorate in Dr. Rosenfeld Laboratory in La Jolla as a Visiting Graduate Student to investigate breast cancer from an epigenetic standpoint. After graduation I become a junior postoctoral fellow in Dr. Rosenfeld Lab. and after three years of training I join Dr. Perissi Lab. as a senior postdoctoral fellow.

In my work as a PhD student I focused on the diverse aspects of the action of estrogen receptor alpha (ERa) in the regulation of gene expression and chromatin architecture in breast cancer. My studies help to establish that estrogen causes an ERa dependent series of interchromosomal interaction, linking transcriptional interactions, elongation and RNA processing event. Also I was able to describe a new role for ERa as a ligand-independent activator that can be essential for the determination of epithelial morphology and epithelial-mesenchymal transition (EMT) during breast cancer progression. In my most recent research I have focused on investigating the role of the nuclear receptor cofactor G Protein Suppressor 2 (GPS2), in regulating non-proteolytic ubiquitin signaling events both inside and outside of the nucleus. Thanks to this work, GPS2 has emerged as a novel and critical regulator of lipid metabolism and inflammation in the adipose tissue.

Boston University
Boston Nutrition Obesity Research Center

Boston Nutrition Obesity Research Center
08/01/2015 - 07/31/2017 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020; 8:608044.View Related Profiles. PMID: 33490071; PMCID: PMC7817781; DOI: 10.3389/fcell.2020.608044;
  2. English J, Son JM, Cardamone MD, Lee C, Perissi V. Decoding the rosetta stone of mitonuclear communication. Pharmacol Res. 2020 11; 161:105161.View Related Profiles. PMID: 32846213; PMCID: PMC7755734; DOI: 10.1016/j.phrs.2020.105161;
  3. Cardamone MD, Orofino J, Labadorf A, Perissi V. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. 2018 11 21; (141).View Related Profiles. PMID: 30531713; PMCID: PMC6684207; DOI: 10.3791/58682;
  4. Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 03 01; 69(5):757-772.e7.View Related Profiles. PMID: 29499132; PMCID: PMC6022402; DOI: 10.1016/j.molcel.2018.01.037;
  5. Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles. PMID: 28539390; PMCID: PMC5887905; DOI: 10.15252/embr.201643827;
  6. Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772.View Related Profiles. PMID: 28039360; PMCID: PMC5314172; DOI: 10.1074/jbc.M116.755132;
  7. Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 01; 6(1):125-137.View Related Profiles. PMID: 28123943; PMCID: PMC5220281; DOI: 10.1016/j.molmet.2016.10.007;
  8. Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31; 290(31):19044-54.View Related Profiles. PMID: 26070566; PMCID: PMC4521029; DOI: 10.1074/jbc.M115.637660;
  9. Cardamone MD, Tanasa B, Chan M, Cederquist CT, Andricovich J, Rosenfeld MG, Perissi V. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR?. Cell Rep. 2014 Jul 10; 8(1):163-76.View Related Profiles. PMID: 24953653; PMCID: PMC4104678; DOI: 10.1016/j.celrep.2014.05.041;
  10. Cardamone MD, Krones A, Tanasa B, Taylor H, Ricci L, Ohgi KA, Glass CK, Rosenfeld MG, Perissi V. A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13; 46(1):91-104.View Related Profiles. PMID: 22424771; PMCID: PMC3327812; DOI: 10.1016/j.molcel.2012.01.025;
Showing 10 of 14 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 3 publications in 2008


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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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