C. James McKnight, PhD Hear my name
Associate Provost and Dean
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Division of Graduate Medical Sciences

PhD, University of Texas Southwestern Medical School
MA, University of Delaware
BS, Washington College

Pronouns: he/him/his

My expertise is in protein structure, function, dynamics and folding and chemistry. Methods used include molecular biology, chromatography, NMR spectroscopy, X-ray crystallography, UV/Vis and circular dichroism spectroscopy, electron microscopy, molecular modeling and dynamics. We look at actin binding proteins (especially those containing villin-type headpiece domains) and lipid binding proteins including apolipoprotein B, the essential protein component of low density lipoprotein (LDL, the bad cholesterol) whose elevated levels are correlated with atherosclerosis, stroke, heart and cardiovascular disease.

Diversity, Equity, Inclusion and Accessibility

I am firmly dedicated to fostering, nurturing and expanding diversity, equity, inclusion and accessibility at Boston University, in the sciences, and everywhere. I try to think about DEIA in all aspects of my roles here at BUSM. I serve on the Graduate Medical Sciences DEI Committee. I have actively participated in the Summer Training as Research Scholars (STaRS) and Baccalaureate Research Education Programs (PREP) since their respective inceptions. These programs bring under-represented groups to the BU campus to gain research experience and professional development to advance their careers in biomedical science and medicine. I have served as a research mentor to several participants in these programs and I present to them on how to apply and interview for graduate school in the biomedical sciences. In my role as chair of the Program in Biomedical Sciences Admissions Committee, I have helped build DEIA into our application and holistic evaluation of applicants. As the Associate Provost and Dean on Graduate Medical Sciences I have helped to implement the Emerging Scholars Awards to provide financial assistance to under-represented groups with the expensive relocation to the Boston Area. I am always looking for new and innovative ways to promote DEIA.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

A Console Upgrade and Cryogenic Probe for a 500 MHz System for Biomedical Research
07/05/2013 - 11/30/2014 (PI)
NIH/Office of the Director

Localizing and Modeling Headpiece Domains on F-Actin
03/01/2002 - 02/28/2007 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM62886 05


Yr Title Project-Sub Proj Pubs
2013 A Console Upgrade and Cryogenic Probe for a 500 MHz NMR System for Biomedical Res 1S10OD011941-01A1 3
2011 25th Annual Symposium of The Protein Society 1R13GM099353-01
2010 Early Events in Lipoprotein Assembly 5R01HL094510-02 3
2010 Physical Equipment Facilities 5P01HL026335-30-9001 235
2009 Early Events in Lipoprotein Assembly 1R01HL094510-01A1 3
2009 Physical Equipment Facilities 5P01HL026335-29-9001 235
2008 Physical Equipment Facilities 5P01HL026335-28-9001 235
2006 Physical Equipment Facilities 2P01HL026335-26-9001 235
2006 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-05 20
2005 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-04 20
Showing 10 of 18 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Vugmeyster L, Ostrovsky D, Rodgers A, Gwin K, Smirnov SL, McKnight CJ, Fu R. Persistence of Methionine Side Chain Mobility at Low Temperatures in a Nine-Residue Low Complexity Peptide, as Probed by 2 H Solid-State NMR. Chemphyschem. 2024 Feb 16; 25(4):e202300565. PMID: 38175858; PMCID: PMC10922872; DOI: 10.1002/cphc.202300565;
  2. Vugmeyster L, Nichols PJ, Ostrovsky D, McKnight CJ, Vögeli B. Slow methyl axes motions in perdeuterated villin headpiece subdomain probed by cross-correlated NMR relaxation measurements. Magnetochemistry. 2023 Jan; 9(1). PMID: 36776538; PMCID: PMC9910280; DOI: 10.3390/magnetochemistry9010033;
  3. Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, Vögeli B, Vugmeyster L. Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Sci. 2020 07; 29(7):1641-1654. PMID: 32356390; PMCID: PMC7314392; DOI: 10.1002/pro.3878;
  4. Vugmeyster L, Griffin A, Ostrovsky D, Bhattacharya S, Nichols PJ, McKnight CJ, Vögeli B. Correlated motions of C'-N and Ca-Cß pairs in protonated and per-deuterated GB3. J Biomol NMR. 2018 Oct; 72(1-2):39-54. PMID: 30121872; PMCID: PMC6218248; DOI: 10.1007/s10858-018-0205-2;
  5. Miears HL, Gruber DR, Horvath NM, Antos JM, Young J, Sigurjonsson JP, Klem ML, Rosenkranz EA, Okon M, McKnight CJ, Vugmeyster L, Smirnov SL. Plant Villin Headpiece Domain Demonstrates a Novel Surface Charge Pattern and High Affinity for F-Actin. Biochemistry. 2018 03 20; 57(11):1690-1701. PMID: 29444403
  6. Xiao R, Dane EL, Zeng J, McKnight CJ, Grinstaff MW. Synthesis of Altrose Poly-amido-saccharides with ß-N-(1?2)-d-amide Linkages: A Right-Handed Helical Conformation Engineered in at the Monomer Level. J Am Chem Soc. 2017 10 11; 139(40):14217-14223.View Related Profiles. PMID: 28902504
  7. Falconer IB, Mant CT, McKnight CJ, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017 Oct 27; 1521:44-52. PMID: 28942999
  8. Chin SL, Lu Q, Dane EL, Dominguez L, McKnight CJ, Straub JE, Grinstaff MW. Combined Molecular Dynamics Simulations and Experimental Studies of the Structure and Dynamics of Poly-Amido-Saccharides. J Am Chem Soc. 2016 05 25; 138(20):6532-40.View Related Profiles. PMID: 27119983; DOI: 10.1021/jacs.6b01837;
  9. Harpole KW, O'Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Protein Sci. 2016 Feb; 25(2):423-32. PMID: 26473993; PMCID: PMC4815346; DOI: 10.1002/pro.2831;
  10. Raina D, Agarwal P, Lee J, Bharti A, McKnight CJ, Sharma P, Kharbanda S, Kufe D. Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. PLoS One. 2015; 10(8):e0135156.View Related Profiles. PMID: 26267657; PMCID: PMC4534190; DOI: 10.1371/journal.pone.0135156;
Showing 10 of 71 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 71 publications over 28 distinct years, with a maximum of 7 publications in 2009


2021 Boston University School of Medicine: October Distinguished Faculty of the Month
2015 Boston University School of Medicine: Educator of the Year in Graduate Medical Sciences Doctoral Degree Program
2011 The Protein Society: Symposium Organizer for the 25th Anniversary Protein Society Symposium
2010-2013 The Protein Society: Elected to the Nominating Committee of The Protein Society

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