My expertise is in protein structure, function, dynamics and folding and chemistry. Methods used include molecular biology, chromatography, NMR spectroscopy, X-ray crystallography, UV/Vis and circular dichroism spectroscopy, electron microscopy, molecular modeling and dynamics. We look at actin binding proteins (especially those containing villin-type headpiece domains) and lipid binding proteins including apolipoprotein B, the essential protein component of low density lipoprotein (LDL, the bad cholesterol) whose elevated levels are correlated with atherosclerosis, stroke, heart and cardiovascular disease.
Diversity, Equity, Inclusion and Accessibility
I am firmly dedicated to fostering, nurturing and expanding diversity, equity, inclusion and accessibility at Boston University, in the sciences, and everywhere. I try to think about DEIA in all aspects of my roles here at BUSM. I serve on the Graduate Medical Sciences DEI Committee. I have actively participated in the Summer Training as Research Scholars (STaRS) and Baccalaureate Research Education Programs (PREP) since their respective inceptions. These programs bring under-represented groups to the BU campus to gain research experience and professional development to advance their careers in biomedical science and medicine. I have served as a research mentor to several participants in these programs and I present to them on how to apply and interview for graduate school in the biomedical sciences. In my role as chair of the Program in Biomedical Sciences Admissions Committee, I have helped build DEIA into our application and holistic evaluation of applicants. As the Associate Provost and Dean on Graduate Medical Sciences I have helped to implement the Emerging Scholars Awards to provide financial assistance to under-represented groups with the expensive relocation to the Boston Area. I am always looking for new and innovative ways to promote DEIA.
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics
Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
A Console Upgrade and Cryogenic Probe for a 500 MHz System for Biomedical Research
07/05/2013 - 11/30/2014 (PI)NIH/Office of the Director1S10OD011941-01A1
Localizing and Modeling Headpiece Domains on F-Actin
03/01/2002 - 02/28/2007 (PI)NIH/National Institute of General Medical Sciences
5 R01 GM62886 05
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Publications listed below are automatically derived from MEDLINE/PubMed and other
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Showing 10 of 70 results.
Vugmeyster L, Nichols PJ, Ostrovsky D, McKnight CJ, Vögeli B. Slow methyl axes motions in perdeuterated villin headpiece subdomain probed by cross-correlated NMR relaxation measurements. Magnetochemistry. 2023 Jan; 9(1). PMID: 36776538; PMCID: PMC9910280; DOI: 10.3390/magnetochemistry9010033;
Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, Vögeli B, Vugmeyster L. Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Sci. 2020 07; 29(7):1641-1654. PMID: 32356390; PMCID: PMC7314392; DOI: 10.1002/pro.3878;
Vugmeyster L, Griffin A, Ostrovsky D, Bhattacharya S, Nichols PJ, McKnight CJ, Vögeli B. Correlated motions of C'-N and Ca-Cß pairs in protonated and per-deuterated GB3. J Biomol NMR. 2018 Oct; 72(1-2):39-54. PMID: 30121872; PMCID: PMC6218248; DOI: 10.1007/s10858-018-0205-2;
Miears HL, Gruber DR, Horvath NM, Antos JM, Young J, Sigurjonsson JP, Klem ML, Rosenkranz EA, Okon M, McKnight CJ, Vugmeyster L, Smirnov SL. Plant Villin Headpiece Domain Demonstrates a Novel Surface Charge Pattern and High Affinity for F-Actin. Biochemistry. 2018 03 20; 57(11):1690-1701. PMID: 29444403
Xiao R, Dane EL, Zeng J, McKnight CJ, Grinstaff MW. Synthesis of Altrose Poly-amido-saccharides with ß-N-(1?2)-d-amide Linkages: A Right-Handed Helical Conformation Engineered in at the Monomer Level. J Am Chem Soc. 2017 10 11; 139(40):14217-14223.View Related Profiles. PMID: 28902504
Falconer IB, Mant CT, McKnight CJ, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017 Oct 27; 1521:44-52. PMID: 28942999
Chin SL, Lu Q, Dane EL, Dominguez L, McKnight CJ, Straub JE, Grinstaff MW. Combined Molecular Dynamics Simulations and Experimental Studies of the Structure and Dynamics of Poly-Amido-Saccharides. J Am Chem Soc. 2016 05 25; 138(20):6532-40.View Related Profiles. PMID: 27119983; DOI: 10.1021/jacs.6b01837;
Harpole KW, O'Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Protein Sci. 2016 Feb; 25(2):423-32. PMID: 26473993; PMCID: PMC4815346; DOI: 10.1002/pro.2831;
Chen L, Brown JW, Mok YF, Hatters DM, McKnight CJ. The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). J Biol Chem. 2015 Jul 17; 290(29):17808. PMID: 26188045; PMCID: PMC4505031; DOI: 10.1074/jbc.A112.438861;
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2021 Boston University School of Medicine:
October Distinguished Faculty of the Month
2015 Boston University School of Medicine:
Educator of the Year in Graduate Medical Sciences Doctoral Degree Program
2011 The Protein Society:
Symposium Organizer for the 25th Anniversary Protein Society Symposium
2010-2013 The Protein Society:
Elected to the Nominating Committee of The Protein Society
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