C. James McKnight, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, University of Texas Southwestern Medical
MA, University of Delaware

My expertise is in protein structure, function, dynamics and folding and chemistry. Methods used include molecular biology, chromatography, NMR spectroscopy, X-ray crystallography, UV/Vis and circular dichroism spectroscopy, electron microscopy, molecular modeling and dynamics. We look at actin binding proteins (especially those containing villin-type headpiece domains) and lipid binding proteins including apolipoprotein B, the essential protein component of low density lipoprotein (LDL, the bad cholesterol) whose elevated levels are correlated with atherosclerosis, stroke, heart and cardiovascular disease.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2015 Boston University School of Medicine: Educator of the Year in Graduate Medical Sciences Doctoral Degree Program
2011 The Protein Society: Symposium Organizer for the 25th Anniversary Protein Society Symposium
2010-2013 The Protein Society: Elected to the Nominating Committee of The Protein Society

A Console Upgrade and Cryogenic Probe for a 500 MHz System for Biomedical Research
07/05/2013 - 11/30/2014 (PI)
NIH/Office of the Director

Localizing and Modeling Headpiece Domains on F-Actin
03/01/2002 - 02/28/2007 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM62886 05


Yr Title Project-Sub Proj Pubs
2013 A Console Upgrade and Cryogenic Probe for a 500 MHz NMR System for Biomedical Res 1S10OD011941-01A1 3
2011 25th Annual Symposium of The Protein Society 1R13GM099353-01
2010 Early Events in Lipoprotein Assembly 5R01HL094510-02 3
2010 Physical Equipment Facilities 5P01HL026335-30-9001 235
2009 Early Events in Lipoprotein Assembly 1R01HL094510-01A1 3
2009 Physical Equipment Facilities 5P01HL026335-29-9001 235
2008 Physical Equipment Facilities 5P01HL026335-28-9001 235
2006 Physical Equipment Facilities 2P01HL026335-26-9001 235
2006 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-05 20
2005 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-04 20
Showing 10 of 18 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, Vögeli B, Vugmeyster L. Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Sci. 2020 07; 29(7):1641-1654. PMID: 32356390; PMCID: PMC7314392; DOI: 10.1002/pro.3878;
  2. Vugmeyster L, Griffin A, Ostrovsky D, Bhattacharya S, Nichols PJ, McKnight CJ, Vögeli B. Correlated motions of C'-N and Ca-Cß pairs in protonated and per-deuterated GB3. J Biomol NMR. 2018 Oct; 72(1-2):39-54. PMID: 30121872; PMCID: PMC6218248; DOI: 10.1007/s10858-018-0205-2;
  3. Miears HL, Gruber DR, Horvath NM, Antos JM, Young J, Sigurjonsson JP, Klem ML, Rosenkranz EA, Okon M, McKnight CJ, Vugmeyster L, Smirnov SL. Plant Villin Headpiece Domain Demonstrates a Novel Surface Charge Pattern and High Affinity for F-Actin. Biochemistry. 2018 03 20; 57(11):1690-1701. PMID: 29444403
  4. Xiao R, Dane EL, Zeng J, McKnight CJ, Grinstaff MW. Synthesis of Altrose Poly-amido-saccharides with ß-N-(1?2)-d-amide Linkages: A Right-Handed Helical Conformation Engineered in at the Monomer Level. J Am Chem Soc. 2017 10 11; 139(40):14217-14223.View Related Profiles. PMID: 28902504
  5. Falconer IB, Mant CT, McKnight CJ, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017 Oct 27; 1521:44-52. PMID: 28942999
  6. Chin SL, Lu Q, Dane EL, Dominguez L, McKnight CJ, Straub JE, Grinstaff MW. Combined Molecular Dynamics Simulations and Experimental Studies of the Structure and Dynamics of Poly-Amido-Saccharides. J Am Chem Soc. 2016 05 25; 138(20):6532-40.View Related Profiles. PMID: 27119983; DOI: 10.1021/jacs.6b01837;
  7. Harpole KW, O'Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Protein Sci. 2016 Feb; 25(2):423-32. PMID: 26473993; PMCID: PMC4815346; DOI: 10.1002/pro.2831;
  8. Raina D, Agarwal P, Lee J, Bharti A, McKnight CJ, Sharma P, Kharbanda S, Kufe D. Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. PLoS One. 2015; 10(8):e0135156.View Related Profiles. PMID: 26267657; PMCID: PMC4534190; DOI: 10.1371/journal.pone.0135156;
  9. Chen L, Brown JW, Mok YF, Hatters DM, McKnight CJ. The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). J Biol Chem. 2015 Jul 17; 290(29):17808. PMID: 26188045; PMCID: PMC4505031; DOI: 10.1074/jbc.A112.438861;
  10. Brown JW, Bullitt E, Sriswasdi S, Harper S, Speicher DW, McKnight CJ. The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap. PLoS Comput Biol. 2015 Jun; 11(6):e1004302.View Related Profiles. PMID: 26067675; PMCID: PMC4466138; DOI: 10.1371/journal.pcbi.1004302;
Showing 10 of 69 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 69 publications over 26 distinct years, with a maximum of 7 publications in 2009


Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Google Map

McKnight's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department